Saeed Nourmohammadi

Higher Degree by Research Candidate

School of Biomedicine

Faculty of Health and Medical Sciences

My Research
Career
Publications
Supervision
Professional Activities
Contact

Aquaporins (AQPs) are members of the Major Intrinsic Protein (MIP) family of channels that facilitate fluid homeostasis across membranes of organisms in all kingdoms of life. The aquaporin family is divided into two groups; classical AQPs selectively carry water, while aquaglyceroporins behave as channels that are permeable to small-uncharged solutes. Recent discoveries in terms of the transport of a wider range of substrates have shed new light on AQP physiological roles. Yet, knowledge on the direct role of specific AQPs in animal pathologies is still limited due to large number of different AQP isoforms and the lack of selective pharmacological modulators.

Using electrophysiology and molecular biology techniques in combination with computational modelling, my work primarily aims to discover new classes of aquaporins that serve as dual water and ion channels and then provide better insights into the novel function of aquaporins, their mechanism of gating and signaling networks in human-related diseases such as malaria and cancer.

Appointments

Date	Position	Institution name
2022 - ongoing	Tutor / Demonstrator (causal)	University of Adelaide
2016 - 2017	Research Assistant	University of Adelaide
2016 - 2016	Technical Assistant	University of Adelaide
2014 - 2015	Laboratory Manager	Zar Macaron Company
2012 - 2012	Teaching and Research Assistant (causal)	Shahid Beheshti University of Medical Sciences
2011 - 2013	R&D	Zar Macaron Company
2006 - 2008	Diagnostic Laboratory Technician	Besat Hospital

Awards and Achievements

Date	Type	Title	Institution Name	Country
2021	Award	AMS/Biomedicine Publication Awards	The University of Adelaide	Australia
2020	Award	Free registration winner for Quality in Postgraduate Research Conference (QPR)	The University of Adelaide	Australia
2019	Award	School of Medicine Travel Award	The University of Adelaide	Australia
2018	Research Award	Best Poster Presentation Award	Australian Society for Medical Research (ASMR)	Australia
2014	Recognition	ITQI award (International Taste and Quality Institute)	Zar Macaron company	Iran, Islamic Republic of
2009	Research Award	Best Poster Presentation Award	Osmania University	India

Language Competencies

Language Competency

English Can read, write, speak, understand spoken and peer review

Persian Can read, write, speak, understand spoken and peer review
Education

Date Institution name Country Title

Osmania University, Hyderabad India Master of Science
Research Interests

Bioinformatics Cancer Cell Biology Cancer Therapy Knowledge Representation and Machine Learning Medical Biotechnology Medical Microbiology Molecular Medicine Plant Cell and Molecular Biology

Language	Competency
English	Can read, write, speak, understand spoken and peer review
Persian	Can read, write, speak, understand spoken and peer review

Date	Institution name	Country	Title
	Osmania University, Hyderabad	India	Master of Science

Journals

Year	Citation
2022	Henderson, S. W., Nourmohammadi, S., Ramesh, S. A., & Yool, A. J. (2022). Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology. Biophysical Reviews, 14(1), 181-198. DOI Scopus1
2022	Chow, P. H., Cox, C. D., Pei, J. V., Anabaraonye, N., Nourmohammadi, S., Henderson, S. W., . . . Yool, A. J. (2022). Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling. Frontiers in Pharmacology, 12, 13 pages. DOI
2020	Chow, P. H., Kourghi, M., Pei, J. V., Nourmohammadi, S., & Yool, A. J. (2020). 5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion. Mol Pharmacol, 98(1), 38-48. DOI Scopus10 WoS9 Europe PMC4
2019	Pei, J. V., Heng, S., De Ieso, M. L., Sylvia, G., Kourghi, M., Nourmohammadi, S., . . . Yool, A. J. (2019). Development of a photoswitchable lithium-sensitive probe to analyze nonselective cation channel activity in migrating cancer cells. Molecular Pharmacology, 95(5), 573-583. DOI Scopus12 WoS11 Europe PMC4
2019	Nourmohammadi, S., Aung, T. N., Cui, J., Pei, J., De Ieso, M. L., Harata-Lee, Y., . . . Yool, A. J. (2019). Effect of compound kushen injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Frontiers in Oncology, 9(APR), 1-14. DOI Scopus27 WoS29 Europe PMC21
2019	De Ieso, M. L., Pei, J. V., Nourmohammadi, S., Smith, E., Chow, P. H., Kourghi, M., . . . Yool, A. J. (2019). Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration. Scientific Reports, 9(1), 12635-1-12635-17. DOI Scopus16 WoS14 Europe PMC10
2019	Aung, T. N., Nourmohammadi, S., Qu, Z., Harata-Lee, Y., Cui, J., Shen, H. Y., . . . Adelson, D. L. (2019). Fractional deletion of Compound Kushen Injection indicates cytokine signaling pathways are critical for its perturbation of the cell cycle. Scientific Reports, 9(1), 14200-1-14200-16. DOI Scopus6 WoS4 Europe PMC4
2018	Mohammadi, K., Movahedi, A., Maleki, S., Sun, W., Zhang, J., Almasi Zadeh Yaghuti, A., . . . Zhuge, Q. (2018). Functional analysis of overexpressed PtDRS1 involved in abiotic stresses enhances growth in transgenic poplar. Plant Physiology and Biochemistry, 126, 22-31. DOI Scopus8 WoS7 Europe PMC4
2018	Kourghi, M., De Ieso, M., Nourmohammadi, S., Pei, J., & Yool, A. (2018). Identification of loop D domain amino acids in the human Aquaporin-1 channel involved in activation of the ionic conductance and inhibition by AqB011. Frontiers in Chemistry, 6(APR), 142-1-142-12. DOI Scopus12 WoS12 Europe PMC6
2018	Kourghi, M., Pei, J., De Ieso, M., Nourmohammadi, S., Chow, P., & Yool, A. (2018). Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Clinical and Experimental Pharmacology and Physiology, 45(4), 401-409. DOI Scopus23 WoS22 Europe PMC9
2017	Kourghi, M., Nourmohammadi, S., Pei, J., Qiu, J., McGaughey, S., Tyerman, S., . . . Yool, A. (2017). Divalent cations regulate the ion conductance properties of diverse classes of aquaporins. International Journal of Molecular Sciences, 18(11), 2323-1-2323-19. DOI Scopus35 WoS32 Europe PMC17
2012	Sheik, Y., Qureshi, S., Venkateshwari, A., Nourmohammadi, S., Mohammad, B., & Nallari, P. (2012). Association of IL-10 & IL-10RA polymorphisms with lymphatic filariasis in South Indian population. International Journal of TROPICAL DISEASE and Health, 2(3), 182-197. DOI
2011	Thazin Nwe Aung, T., & Nourmohammadi, S. (2011). Isolation of endophytic bacteria from green gram and study on their plant growth promoting activities. International Journal of Applied Biology and Pharmaceutical Technology, 2(3), 525-537.

Conference Items

Year	Citation
2021	Nourmohammadi, S. (2021). (Oral presentation) Aquaporins- from novel function to malaria. Poster session presented at the meeting of The Australian Society for Medical Research (ASMR).
2021	Nourmohammadi, S. (2021). (Poster presentation) Discovering the molecular identity of a cation channel involved in survival and drug resistance of the malarial parasite Plasmodium falciparum. Poster session presented at the meeting of Florey Postgraduate Research Conference.
2020	Nourmohammadi, S., & Yool, A. (2020). (Oral presentation) Discovering New Cancer-linked Ion Channels using a Photoswitchable Lithium Porbe. Poster session presented at the meeting of 3-minutes talk competition, The Institute for Photonics and Advanced Sensing (IPAS). University of Adelaide.
2019	Nourmohammadi, S., Nwe Aung, T., Cui, J., Pei, J., De leso, M., Qu, Z., . . . Yool, A. (2019). (Oral presentation) Systematic dissection of the molecular actions of compounds from traditional medicinal mixtures on the migration, invasion and apoptosis of brain, bowel and breast cancer cells. Poster session presented at the meeting of AuPS/ABS Meeting, Canberra, 2019.
2019	Nourmohammadi, S. (2019). (Invited talk) Effect of compound kushen injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Poster session presented at the meeting of Opening talk at launching a new institute of Zhendong Pharma, Beijing, China.
2019	Nourmohammadi, S., Yool, A., & Adelson, D. (2019). (Poster presentation) Natural Compounds as Potential Anti-metastatic Treatments for Brain, Bowel and Breast Cancer. Poster session presented at the meeting of Florey Postgraduate Conference.
2018	Nourmohammadi, S., Nwe Aung, T., Yool, A., & Adelson, D. (2018). (Poster presentation) Fractional Deletion of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical for Its Perturbation of The Cell Cycle. Poster session presented at the meeting of Florey Postgraduate Conference.
2018	Nourmohammadi, S., Yool, A., & Adelson, D. (2018). (Poster presentation) Discovery of the Anti-metastasic Activity of a Chinese medicinal herb mixture 'Compound Kushen Injection' and Identification of the Active Components in Brain, Colon and Breast Cancer Cell Lines. Poster session presented at the meeting of Australian Society for Medical Research (ASMR).
2017	Nourmohammadi, S., Pie, V. J., Kourghi, M., De leso, M. L., Pak, C., Adelson, D. L., & Yool, A. J. (2017). (Oral presentation) Analysis of effective compounds and mechanisms of action of a Chinese traditional herbal medicine (Compound Kushen Injection) on aquaporins involved in cancer cell migration and metastasis.. Poster session presented at the meeting of Gage Ion Channels and Transporters Conference. Canberra, Australia.

Other Supervision Activities

Date	Role	Research Topic	Location	Program	Supervision Type	Student Load	Student Name
2020 - ongoing	Co-Supervisor	Brain Cancer	University of Adelaide	The Bachelor of Health and Medical Sciences (BHMS) 3rd year Research Placement course-2020	Other		Madison Boda, Annaliese Thompson, Timothy Kwok, Kenny Cao
2020 - ongoing	Co-Supervisor	Brain Cancer	University of Adelaide		Honours		Alanah Varricchio
2012 - 2012	Other	The effect of injected allogeneic fibroblasts in patients suffering from Junctional epidermolysis bullosa	Shahid Beheshti University of Medical Sciences	Workshop	Master	Part Time	Pharmacology students

Mentoring

Date	Topic	Location	Name
2019 - ongoing	Endometrial Cancer, Insect pathology	University of Adelaide	Sidra Khan, Biko Muita
2019 - 2020	Brain and Colorectal cancer	University of Adelaide	Zein Amro, Sher Lyn Yong

Community Engagement

Date	Title	Engagement Type	Institution
2021 - ongoing	National Relations Assistant and Conference Organizer	Scientific Community Engagement	The Australian Physiological Society
2020 - ongoing	Cultural ambassador	Public Community Engagement	The University of Adelaide
2020 - ongoing	Journal Reviewer	Scientific Community Engagement	Frontiers in Pharmacology journal
2020 - ongoing	Board member	Scientific Community Engagement	The University of Adelaide, Medical School, Helen Mayo Precinct
2020 - ongoing	Events Coordinator Head	Scientific Community Engagement	The University of Adelaide, Health Sciences Postgraduate Association (HeSPA)

Event Participation

Date	Event Name	Event Type	Institution	Country
2020 - ongoing	Conference Assessor, 3rd Year Research Placement Students	Conference	The University of Adelaide
2019 - ongoing	Conference Assessor, Florey Undergraduate Research Conference	Conference	The University of Adelaide

Email: saeed.nourmohammadi@adelaide.edu.au
Campus: North Terrace
Building: Helen Mayo North
Org Unit: Medical Specialties

Saeed Nourmohammadi

Appointments

Awards and Achievements

Language Competencies

Education

Research Interests