
Saeed Nourmohammadi
Higher Degree by Research Candidate
Adelaide Medical School
Faculty of Health and Medical Sciences
Aquaporins (AQPs) are members of the Major Intrinsic Protein (MIP) family of channels that facilitate fluid homeostasis across membranes of organisms in all kingdoms of life. The aquaporin family is divided into two groups; classical AQPs selectively carry water, while aquaglyceroporins behave as channels that are permeable to small-uncharged solutes. Recent discoveries in terms of the transport of a wider range of substrates have shed new light on AQP physiological roles. Their critical role in diverse physiological functions make AQP channels attractive targets for the discovery of pharmacological modulators. Certain types of cancers metastasize with aggressiveness that correlates with the level of AQPs expression. Yet, knowledge on the direct role of specific AQPs in animal
pathologies is still limited due to large number of different AQP isoforms and the lack of selective pharmacological modulators.
Our goals are to elucidate the signaling networks in AQP-related diseases, especially cancer metastasis in mammals, and discover novel AQP antagonist and agonist compounds as tools for clinical research. In future, cancer therapeutic interventions such as surgical, chemo and radiotherapy, might be found to benefit from adjunct treatment with AQP blockers for slowing cancer metastasis.
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Appointments
Date Position Institution name 2016 - 2017 Research assistant University of Adelaide, Adelaide 2012 - 2013 Lab Manager Zar Macaron Company, Tehran, Iran 2011 - 2012 Research assistant Shahid Beheshti University of Medical Sciences, Tehran -
Awards and Achievements
Date Type Title Institution Name Country Amount 2020 Award Free registration winner for Quality in Postgraduate Research 2020 Conference (QPR) University of Adelaide Australia — 2018 Scholarship Adelaide Scholarships International (ASI) University of Adelaide Australia — 2018 Award Best Poster (Poeple's choice) The Australian Society for Medical Research (ASMR) Australia — 2013 Award ITQI award (International Taste and Quality Institute) Zarmacaron company Iran, Islamic Republic of — 2011 Achievement M.Sc First Class Grade Osmania University, Hyderabad India — -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Persian Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title — Osmania University, Hyderabad India Master of Science -
Research Interests
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Journals
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Conference Items
Year Citation 2020 Nourmohammadi, S., & Yool, A. (2020). (Oral presentation) Discovering New Cancer-linked Ion Channels using a Photoswitchable Lithium Porbe. Poster session presented at the meeting of 3-minutes talk competition, The Institute for Photonics and Advanced Sensing (IPAS). University of Adelaide. 2019 Nourmohammadi, S., Nwe Aung, T., Cui, J., Pei, J., De leso, M., Qu, Z., . . . Yool, A. (2019). (Oral presentation) Systematic dissection of the molecular actions of compounds from traditional medicinal mixtures on the migration, invasion and apoptosis of brain, bowel and breast cancer cells. Poster session presented at the meeting of AuPS/ABS Meeting, Canberra, 2019. 2019 Nourmohammadi, S., Yool, A., & Adelson, D. (2019). (Poster presentation) Natural Compounds as Potential Anti-metastatic Treatments for Brain, Bowel and Breast Cancer. Poster session presented at the meeting of Florey Postgraduate Conference. 2018 Nourmohammadi, S., Nwe Aung, T., Yool, A., & Adelson, D. (2018). (Poster presentation) Fractional Deletion of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical for Its Perturbation of The Cell Cycle. Poster session presented at the meeting of Florey Postgraduate Conference. 2018 Nourmohammadi, S., Yool, A., & Adelson, D. (2018). (Poster presentation) Discovery of the Anti-metastasic Activity of a Chinese medicinal herb mixture 'Compound Kushen Injection' and Identification of the Active Components in Brain, Colon and Breast Cancer Cell Lines. Poster session presented at the meeting of Australian Society for Medical Research (ASMR). 2017 Nourmohammadi, S., Pie, V. J., Kourghi, M., De leso, M. L., Pak, C., Adelson, D. L., & Yool, A. J. (2017). (Oral presentation) Analysis of effective compounds and mechanisms of action of a Chinese traditional herbal medicine (Compound Kushen Injection) on aquaporins involved in cancer cell migration and metastasis.. Poster session presented at the meeting of Gage Ion Channels and Transporters Conference. Canberra, Australia.
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Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2020 - ongoing Co-Supervisor Brain Cancer University of Adelaide The Bachelor of Health and Medical Sciences (BHMS) 3rd year Research Placement course-2020 Other — Madison Boda, Annaliese Thompson, Timothy Kwok, Kenny Cao 2020 - ongoing Co-Supervisor Brain Cancer University of Adelaide — Honours — Alanah Varricchio 2012 - 2012 Other The effect of injected allogeneic fibroblasts in patients suffering from Junctional epidermolysis bullosa Shahid Beheshti University of Medical Sciences Workshop Master Part Time Pharmacology students -
Mentoring
Date Topic Location Name 2019 - ongoing Endometrial Cancer, Insect pathology University of Adelaide Sidra Khan, Biko Muita 2019 - 2020 Brain and Colorectal cancer University of Adelaide Zein Amro, Sher Lyn Yong
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Memberships
Date Role Membership Country 2021 - ongoing Member Australian Bioinformatics and Computational Biology (ABACBS) Australia 2021 - ongoing Member International Society for Computational Biology (ISCB) United States 2021 - ongoing Member Biophysical Society (BPS) United States 2020 - ongoing Member The Institute of Photonics and Advanced Sensing (IPAS) Australia 2019 - ongoing Member Australian Yeast Group (AYG) Australia 2019 - ongoing Member Australian Society for Physiology (AuPS) Australia 2019 - ongoing Member Australian Society for Biophysics (ASB) Australia 2018 - ongoing Member Australian Society for Medical Research (ASMR) Australia
Connect With Me
External Profiles