Saeed Nourmohammadi

Higher Degree by Research Candidate

Adelaide Medical School

Faculty of Health and Medical Sciences

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Aquaporins (AQPs) are members of the Major Intrinsic Protein (MIP) family of channels that facilitate fluid homeostasis across membranes of organisms in all kingdoms of life. The aquaporin family is divided into two groups; classical AQPs selectively carry water, while aquaglyceroporins behave as channels that are permeable to small-uncharged solutes. Recent discoveries in terms of the transport of a wider range of substrates have shed new light on AQP physiological roles. Their critical role in diverse physiological functions make AQP channels attractive targets for the discovery of pharmacological modulators. Certain types of cancers metastasize with aggressiveness that correlates with the level of AQPs expression. Yet, knowledge on the direct role of specific AQPs in animal
pathologies is still limited due to large number of different AQP isoforms and the lack of selective pharmacological modulators.

Our goals are to elucidate the signaling networks in AQP-related diseases, especially cancer metastasis in mammals, and discover novel AQP antagonist and agonist compounds as tools for clinical research. In future, cancer therapeutic interventions such as surgical, chemo and radiotherapy, might be found to benefit from adjunct treatment with AQP blockers for slowing cancer metastasis.

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Appointments

Date	Position	Institution name
2016 - 2017	Research assistant	University of Adelaide, Adelaide
2012 - 2013	Lab Manager	Zar Macaron Company, Tehran, Iran
2011 - 2012	Research assistant	Shahid Beheshti University of Medical Sciences, Tehran

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2020	Award	Free registration winner for Quality in Postgraduate Research 2020 Conference (QPR)	University of Adelaide	Australia	—
2018	Scholarship	Adelaide Scholarships International (ASI)	University of Adelaide	Australia	—
2018	Award	Best Poster (Poeple's choice)	The Australian Society for Medical Research (ASMR)	Australia	—
2013	Award	ITQI award (International Taste and Quality Institute)	Zarmacaron company	Iran, Islamic Republic of	—
2011	Achievement	M.Sc First Class Grade	Osmania University, Hyderabad	India	—

Language Competencies

Language Competency
English Can read, write, speak, understand spoken and peer review
Persian Can read, write, speak, understand spoken and peer review
Education

Date Institution name Country Title
— Osmania University, Hyderabad India Master of Science
Research Interests

Cancer Cell Biology Cancer Therapy Medical Biotechnology Medical Microbiology Molecular Medicine Plant Cell and Molecular Biology

Language	Competency
English	Can read, write, speak, understand spoken and peer review
Persian	Can read, write, speak, understand spoken and peer review

Date	Institution name	Country	Title
—	Osmania University, Hyderabad	India	Master of Science

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Journals

Year	Citation
2020	Chow, P. H., Kourghi, M., Pei, J. V., Nourmohammadi, S., & Yool, A. J. (2020). 5-hydroxymethyl-furfural and structurally related compounds block the ion conductance in human aquaporin-1 channels, and slow cancer cell migration and invasion.. Mol Pharmacol, 98(1), 38-48. DOI Scopus4 WoS2 Europe PMC1
2019	Pei, J. V., Heng, S., De Ieso, M. L., Sylvia, G., Kourghi, M., Nourmohammadi, S., . . . Yool, A. J. (2019). Development of a photoswitchable lithium-sensitive probe to analyze nonselective cation channel activity in migrating cancer cells. Molecular Pharmacology, 95(5), 573-583. DOI Scopus4 WoS4 Europe PMC2
2019	Nourmohammadi, S., Aung, T. N., Cui, J., Pei, J., De Ieso, M. L., Harata-Lee, Y., . . . Yool, A. J. (2019). Effect of compound kushen injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain, and breast cancer cell lines. Frontiers in Oncology, 9(APR), 1-14. DOI Scopus13 WoS13 Europe PMC10
2019	De Ieso, M. L., Pei, J. V., Nourmohammadi, S., Smith, E., Chow, P. H., Kourghi, M., . . . Yool, A. J. (2019). Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration. Scientific Reports, 9(1), 12635-1-12635-17. DOI Scopus7 WoS7 Europe PMC5
2019	Aung, T. N., Nourmohammadi, S., Qu, Z., Harata-Lee, Y., Cui, J., Shen, H. Y., . . . Adelson, D. L. (2019). Fractional deletion of Compound Kushen Injection indicates cytokine signaling pathways are critical for its perturbation of the cell cycle. Scientific Reports, 9(1), 14200-1-14200-16. DOI
2018	Mohammadi, K., Movahedi, A., Maleki, S., Sun, W., Zhang, J., Almasi Zadeh Yaghuti, A., . . . Zhuge, Q. (2018). Functional analysis of overexpressed PtDRS1 involved in abiotic stresses enhances growth in transgenic poplar. Plant Physiology and Biochemistry, 126, 22-31. DOI Scopus1 WoS2 Europe PMC1
2018	Kourghi, M., De Ieso, M., Nourmohammadi, S., Pei, J., & Yool, A. (2018). Identification of loop D domain amino acids in the human Aquaporin-1 channel involved in activation of the ionic conductance and inhibition by AqB011. Frontiers in Chemistry, 6(APR), 142-1-142-12. DOI Scopus6 WoS7 Europe PMC4
2018	Kourghi, M., Pei, J., De Ieso, M., Nourmohammadi, S., Chow, P., & Yool, A. (2018). Fundamental structural and functional properties of Aquaporin ion channels found across the kingdoms of life. Clinical and Experimental Pharmacology and Physiology, 45(4), 401-409. DOI Scopus7 WoS7 Europe PMC2
2017	Kourghi, M., Nourmohammadi, S., Pei, J., Qiu, J., McGaughey, S., Tyerman, S., . . . Yool, A. (2017). Divalent cations regulate the ion conductance properties of diverse classes of aquaporins. International Journal of Molecular Sciences, 18(11), 2323-1-2323-19. DOI Scopus18 WoS18 Europe PMC8
2012	Sheik, Y., Qureshi, S., Venkateshwari, A., Nourmohammadi, S., Mohammad, B., & Nallari, P. (2012). Association of IL-10 & IL-10RA polymorphisms with lymphatic filariasis in South Indian population. International Journal of TROPICAL DISEASE and Health, 2(3), 182-197. DOI
2011	Thazin Nwe Aung, T., & Nourmohammadi, S. (2011). Isolation of endophytic bacteria from green gram and study on their plant growth promoting activities. International Journal of Applied Biology and Pharmaceutical Technology, 2(3), 525-537.

Conference Items

Year	Citation
2020	Nourmohammadi, S., & Yool, A. (2020). (Oral presentation) Discovering New Cancer-linked Ion Channels using a Photoswitchable Lithium Porbe. Poster session presented at the meeting of 3-minutes talk competition, The Institute for Photonics and Advanced Sensing (IPAS). University of Adelaide.
2019	Nourmohammadi, S., Nwe Aung, T., Cui, J., Pei, J., De leso, M., Qu, Z., . . . Yool, A. (2019). (Oral presentation) Systematic dissection of the molecular actions of compounds from traditional medicinal mixtures on the migration, invasion and apoptosis of brain, bowel and breast cancer cells. Poster session presented at the meeting of AuPS/ABS Meeting, Canberra, 2019.
2019	Nourmohammadi, S., Yool, A., & Adelson, D. (2019). (Poster presentation) Natural Compounds as Potential Anti-metastatic Treatments for Brain, Bowel and Breast Cancer. Poster session presented at the meeting of Florey Postgraduate Conference.
2018	Nourmohammadi, S., Nwe Aung, T., Yool, A., & Adelson, D. (2018). (Poster presentation) Fractional Deletion of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical for Its Perturbation of The Cell Cycle. Poster session presented at the meeting of Florey Postgraduate Conference.
2018	Nourmohammadi, S., Yool, A., & Adelson, D. (2018). (Poster presentation) Discovery of the Anti-metastasic Activity of a Chinese medicinal herb mixture 'Compound Kushen Injection' and Identification of the Active Components in Brain, Colon and Breast Cancer Cell Lines. Poster session presented at the meeting of Australian Society for Medical Research (ASMR).
2017	Nourmohammadi, S., Pie, V. J., Kourghi, M., De leso, M. L., Pak, C., Adelson, D. L., & Yool, A. J. (2017). (Oral presentation) Analysis of effective compounds and mechanisms of action of a Chinese traditional herbal medicine (Compound Kushen Injection) on aquaporins involved in cancer cell migration and metastasis.. Poster session presented at the meeting of Gage Ion Channels and Transporters Conference. Canberra, Australia.

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Other Supervision Activities

Date	Role	Research Topic	Location	Program	Supervision Type	Student Load	Student Name
2020 - ongoing	Co-Supervisor	Brain Cancer	University of Adelaide	The Bachelor of Health and Medical Sciences (BHMS) 3rd year Research Placement course-2020	Other	—	Madison Boda, Annaliese Thompson, Timothy Kwok, Kenny Cao
2020 - ongoing	Co-Supervisor	Brain Cancer	University of Adelaide	—	Honours	—	Alanah Varricchio
2012 - 2012	Other	The effect of injected allogeneic fibroblasts in patients suffering from Junctional epidermolysis bullosa	Shahid Beheshti University of Medical Sciences	Workshop	Master	Part Time	Pharmacology students

Mentoring

Date	Topic	Location	Name
2019 - ongoing	Endometrial Cancer, Insect pathology	University of Adelaide	Sidra Khan, Biko Muita
2019 - 2020	Brain and Colorectal cancer	University of Adelaide	Zein Amro, Sher Lyn Yong

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Memberships

Date	Role	Membership	Country
2021 - ongoing	Member	Australian Bioinformatics and Computational Biology (ABACBS)	Australia
2021 - ongoing	Member	International Society for Computational Biology (ISCB)	United States
2021 - ongoing	Member	Biophysical Society (BPS)	United States
2020 - ongoing	Member	The Institute of Photonics and Advanced Sensing (IPAS)	Australia
2019 - ongoing	Member	Australian Yeast Group (AYG)	Australia
2019 - ongoing	Member	Australian Society for Physiology (AuPS)	Australia
2019 - ongoing	Member	Australian Society for Biophysics (ASB)	Australia
2018 - ongoing	Member	Australian Society for Medical Research (ASMR)	Australia

Email: saeed.nourmohammadi@adelaide.edu.au
Campus: North Terrace
Building: Helen Mayo North
Org Unit: Medical Specialties

Saeed Nourmohammadi

Appointments

Awards and Achievements

Language Competencies

Education

Research Interests

Journals

Conference Items

Other Supervision Activities

Mentoring

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