Dr Ruby Dawson
ECR, Tumour Inflammation & Immunotherapy
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Ruby Dawson is an early-career researcher (ECR) who has made significant contributions to cancer research and was recently recruited to the South Australian immunoGenomics Cancer Institute (SAiGENCI). Ruby’s work focuses on the roles of innate immune sensors in the development of gastric cancer and Helicobacter-induced gastric inflammation.
Since completing her PhD at the University of Adelaide, Ruby has published two first-author papers in the prestigious Gut journal and Immunology and Cell Biology, which investigate the role of the innate immune DNA sensor, AIM2, in gastric inflammation and tumourigenesis. She is continuing this work with funding from a United States Department of Defense Cancer Research Program Idea Award received by Prof. Jenkins in 2022. She also has co-authorship on manuscripts in other reputable journals which investigate mechanisms of gastric cancer, a review on IL-6 family cytokines (Cytokine) and a book chapter based on the innate immune system in gastric cancer that is part of book series entitled “Research and Clinical Applications of Targeting Gastric Neoplasms” (Elsevier).
Ruby is active in the wider scientific community as an elected junior council member of the International Cytokine and Interferon Society (ICIS) and an ECR representative on the Victorian Infection and Immunity Network (VIIN) Young Investigator Committee.
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Appointments
Date Position Institution name 2024 - ongoing Postdoctoral Researcher University of Adelaide 2019 - 2023 Postdoctoral Researcher Hudson Institute of Medical Research
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Journals
Year Citation 2023 Dawson, R. E., Deswaerte, V., West, A. C., Sun, E., Wray-McCann, G., Livis, T., . . . Jenkins, B. J. (2023). The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome. Immunology and Cell Biology, 101(5), 444-457.
Scopus2 Europe PMC12022 Tang, K., McLeod, L., Livis, T., West, A. C., Dawson, R., Yu, L., . . . Jenkins, B. J. (2022). Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation. Cellular and Molecular Gastroenterology and Hepatology, 14(3), 567-586.
Scopus7 WoS6 Europe PMC52022 Dawson, R. E., Deswaerte, V., West, A. C., Tang, K., West, A. J., Balic, J. J., . . . Jenkins, B. J. (2022). STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut, 71(8), 1515-1531.
Scopus21 WoS16 Europe PMC162021 Gurumurthy, C. B., O’Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., . . . Yoshiki, A. (2021). Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”. Genome Biology, 22(1), 99.
Scopus2 WoS2 Europe PMC22021 Thomson, E., Dawson, R., H'ng, C. H., Adikusuma, F., Piltz, S., & Thomas, P. Q. (2021). The Nestin neural enhancer is essential for normal levels of endogenous Nestin in neuroprogenitors but is not required for embryo development. PLoS One, 16(11), e0258538-1-e0258538-16.
Scopus2 WoS1 Europe PMC22021 Dawson, R. E., Jenkins, B. J., & Saad, M. I. (2021). IL-6 family cytokines in respiratory health and disease. Cytokine, 143, 1-10.
Scopus14 WoS11 Europe PMC72020 Dawson, R., Guil, A. N., Robertson, L., Piltz, S., Hughes, J., & Thomas, P. (2020). Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy. Neurobiology of Disease, 134, 104640.
Scopus28 WoS22 Europe PMC162020 Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P., & Jenkins, B. J. (2020). STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation. Cytokine, 130, 6 pages.
Scopus3 WoS2 Europe PMC22020 Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., . . . Jenkins, B. J. (2020). Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. American Journal of Pathology, 190(6), 1256-1270.
Scopus16 WoS12 Europe PMC112019 Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., . . . Yoshiki, A. (2019). Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation. Genome Biology, 20(1), 14 pages.
Scopus56 WoS40 Europe PMC432017 Hughes, J., Dawson, R., Tea, M., McAninch, D., Piltz, S., Jackson, D., . . . Thomas, P. (2017). Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling. Scientific Reports, 7(1), 12618-1-12618-15.
Scopus39 WoS36 Europe PMC31 -
Book Chapters
Year Citation 2021 Dawson, R., & Jenkins, B. J. (2021). Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment. In Research and Clinical Applications of Targeting Gastric Neoplasms (pp. 43-90). Elsevier.
2018 Thomson, E. P., Dawson, R. E., Hughes, J. N., & Thomas, P. Q. (2018). CRISPR Genome Editing in Mice. In Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery (pp. 165-180). Cambridge University Press.
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