Dr Ruby Dawson
Grant-Funded Researcher (B)
SAIGENCI
College of Health
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Ruby Dawson is an early-career researcher (ECR) who has made significant contributions to cancer research and was recently recruited to the South Australian immunoGenomics Cancer Institute (SAiGENCI). Ruby’s work focuses on the roles of innate immune sensors in the development of gastric cancer and Helicobacter-induced gastric inflammation. Since completing her PhD at the University of Adelaide, Ruby has published two first-author papers in the prestigious Gut journal and Immunology and Cell Biology, which investigate the role of the innate immune DNA sensor, AIM2, in gastric inflammation and tumourigenesis. She is continuing this work with funding from a United States Department of Defense Cancer Research Program Idea Award received by Prof. Jenkins in 2022. She also has co-authorship on manuscripts in other reputable journals which investigate mechanisms of gastric cancer, a review on IL-6 family cytokines (Cytokine) and a book chapter based on the innate immune system in gastric cancer that is part of book series entitled “Research and Clinical Applications of Targeting Gastric Neoplasms” (Elsevier).Ruby is active in the wider scientific community as an elected junior council member of the International Cytokine and Interferon Society (ICIS) and an ECR representative on the Victorian Infection and Immunity Network (VIIN) Young Investigator Committee.
| Date | Position | Institution name |
|---|---|---|
| 2024 - ongoing | Postdoctoral Researcher | University of Adelaide |
| 2019 - 2023 | Postdoctoral Researcher | Hudson Institute of Medical Research |
| Year | Citation |
|---|---|
| 2026 | Chey, Y. C. J., Kashgari, B., McLeod, L., Radford, G. A., Gearing, L. J., Dawson, R. E., . . . Jenkins, B. J. (2026). Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer. Nature Communications, 17(1), 2477-1-2477-21. Scopus1 WoS1 |
| 2026 | Chan, S., Hon, K., Dawson, R. E., Weng, T., Solujic, J., Chey, Y. C. J., . . . Saad, M. I. (2026). The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis. British Journal of Pharmacology, 183(15), 4126-4144. |
| 2024 | Dawson, R. E., & Jenkins, B. J. (2024). The Role of Inflammasome-Associated Innate Immune Receptors in Cancer. Immune network, 24(5), e38-1-e38-23. Scopus14 WoS14 Europe PMC13 |
| 2023 | Dawson, R. E., Deswaerte, V., West, A. C., Sun, E., Wray‐McCann, G., Livis, T., . . . Jenkins, B. J. (2023). The cytosolic DNA sensor AIM2 promotes Helicobacter‐induced gastric pathology via the inflammasome. Immunology and Cell Biology, 101(5), 444-457. Scopus13 WoS12 Europe PMC11 |
| 2022 | Dawson, R. E., Deswaerte, V., West, A. C., Tang, K., West, A. J., Balic, J. J., . . . Jenkins, B. J. (2022). STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis. Gut, 71(8), 1515-1531. Scopus36 WoS36 Europe PMC32 |
| 2022 | Tang, K., McLeod, L., Livis, T., West, A. C., Dawson, R., Yu, L., . . . Jenkins, B. J. (2022). Toll-like Receptor 9 Promotes Initiation of Gastric Tumorigenesis by Augmenting Inflammation and Cellular Proliferation. Cellular and Molecular Gastroenterology and Hepatology, 14(3), 567-586. Scopus16 WoS17 Europe PMC15 |
| 2021 | Gurumurthy, C. B., O’Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., . . . Yoshiki, A. (2021). Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”. Genome Biology, 22(1), 99. Scopus2 WoS3 Europe PMC5 |
| 2021 | Thomson, E., Dawson, R., H'ng, C. H., Adikusuma, F., Piltz, S., & Thomas, P. Q. (2021). The Nestin neural enhancer is essential for normal levels of endogenous Nestin in neuroprogenitors but is not required for embryo development. PLoS One, 16(11), e0258538-1-e0258538-16. Scopus3 WoS5 Europe PMC3 |
| 2021 | Dawson, R. E., Jenkins, B. J., & Saad, M. I. (2021). IL-6 family cytokines in respiratory health and disease. Cytokine, 143, 1-10. Scopus56 WoS50 Europe PMC35 |
| 2020 | Dawson, R., Guil, A. N., Robertson, L., Piltz, S., Hughes, J., & Thomas, P. (2020). Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy. Neurobiology of Disease, 134, 104640. Scopus40 WoS35 Europe PMC31 |
| 2020 | Balic, J. J., Saad, M. I., Dawson, R., West, A. J., McLeod, L., West, A. C., . . . Jenkins, B. J. (2020). Constitutive STAT3 Serine Phosphorylation Promotes Helicobacter-Mediated Gastric Disease. The American Journal of Pathology, 190(6), 1256-1270. Scopus27 WoS22 Europe PMC20 |
| 2020 | Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P., & Jenkins, B. J. (2020). STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation. Cytokine, 130, 155059. Scopus6 WoS5 Europe PMC3 |
| 2019 | Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., . . . Yoshiki, A. (2019). Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation. Genome Biology, 20(1), 14 pages. Scopus66 WoS56 Europe PMC71 |
| 2017 | Hughes, J., Dawson, R., Tea, M., McAninch, D., Piltz, S., Jackson, D., . . . Thomas, P. (2017). Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling. Scientific Reports, 7(1), 12618-1-12618-15. Scopus51 WoS48 Europe PMC49 |
| Year | Citation |
|---|---|
| 2021 | Dawson, R., & Jenkins, B. J. (2021). Unravelling the pro-tumorigenic role of innate immune pattern recognition receptors in the gastric compartment. In Research and Clinical Applications of Targeting Gastric Neoplasms (pp. 43-90). Elsevier. DOI |
| 2018 | Thomson, E. P., Dawson, R. E., Hughes, J. N., & Thomas, P. Q. (2018). CRISPR Genome Editing in Mice. In Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery (pp. 165-180). CAMBRIDGE UNIV PRESS. DOI |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2026 | Co-Supervisor | Investigation of the Roles of Innate Immune DNA sensors in Gastric Inflammation and Gastric Cancer | Master of Research | Master | Full Time | Mr Rex Daileg |
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