
Professor Robert Casson
Head of Ophthalmology & Visual Sciences
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Professor Robert Casson MB,BS (Hons), M.Biostatistics, DPhil, FRANZCO heads the Ophthalmic Research Laboratory in the Discipline of Ophthalmology and Visual Science at Adelaide University. He is an internationally recognized ophthalmic clinician/scientist with special interests in glaucoma, retinal cell biology, neuroprotection, ophthalmic epidemiology and translational ophthalmic research. After completion of a laboratory-based DPhil in 2004 he returned to Australia and established the South Australian Institute of Ophthalmology (SAIO), including the Ophthalmic Research Laboratory co-located with Neuropathology in the Hanson Institute. In June 2017, the lab moved to the new AHMS building. In 2012, he completed a Masters of Biostatistics at Adelaide University.He has approximately 250 publications, and multiple NHMRC grants. He is a founding board member of the ophthalmologist-led, evidence-based NGO, Sight for All, and took over as Chair in Nov. 2022. He is a core member of the Global Burden of Disease Study, Vision Loss Expert Group. He graduated with an Order of Merit from the Australian Institute of Company Directors Course in 2023.
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Available Research Projects
Ophthalmic Research Lab
Research Project 1 - Bioenergetic Neuroprotection in Glaucoma
Project description: This is a translational project that advances our world leading research in the field of retinal bioenergetic neuroprotection. Glaucoma is a common, potentially blinding disease. Currently treatment is limited to lowering the intraocular pressure. Our lab is investigating new energy supplementation treatments in animal models of glaucoma with a view to rapid clinical translation.
Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS
Research project start: Semester 1 and 2
Special requirements: Nil
Research Project 2 - Bioenergetic Neuroprotection in Glaucoma
Project description: This is a basic science project that advances our world leading research in the field of retinal energy metabolism. We are utilizing in vivo immunohistochemistry in different species to obtain a detailed profile of the enzymes and transporters involved in retinal energy metabolism in vascular and avascular retinas.
Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS
Research project start: Semester 1 and 2
Special requirements: Nil
Research Project 3 - New Treatments for Age-related Macular Degeneration
Project description:This project will investigate 3 novel treatments for age-related macular degeneration (AMD). We have 3 exciting novel therapies that we have developed from our previous research that we believe are highly applicable to the ischaemic/oxidative stress component of AMD and choroidal neovascularisation.
The first therapy is a novel, slit-lamp-delivered low energy laser with a 670 nm wavelength. This laser enhances mitochondrial function and reduces oxidative stress. We have recently demonstrated that this laser has a spectacular protective effect against cone degeneration in a model of retinitis pigmentosa and we believe it is translatable to AMD.
The second therapy is a novel calpain antagonist. We recently discovered that this agent has an extremely robust neuroprotective effect in experimental retinal ischemia and is highly likely to protect the retinal pigment epithelium and photoreceptors against ischemic injury.
The third therapy is a novel cardiac-derived peptide that has been shown to have powerful anti-angiogenic effects. The particular appeal of this agent is that its molecular weight is very small (~3.9 kDa); hence, it could potentially be delivered topically, eliminating or reducing the need for intravitreal injections.
We will investigate these novel therapies in retinal pigment epithelial cell culture models and in a rat model of choroidal neovascularisation.
Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS
Research project start: Semester 1 and 2
Special requirements: Nil
Research Project 4 - New Treatments for Age-related Macular Degeneration
Project description: Photobiomodulation (PBM) refers to the treatment the treatment of tissue with light in the far-red to near-infrared spectrum (630-1000 nm). Most evidence supports an action of PBM on energy metabolism, in particular, Complex IV of the mitochondrial electron transport chain, but other mechanisms, including anti-oxidant and anti-neuroinflammatory effects, have been proposed. Our in vitro results strongly supported a protective effect on retinal neurons. We used the laser in an attempt to prevent secondary cone photoreceptor degeneration in a rodent model of severe retinitis pigmentosa (RP). The reproducible rescue of cones was extraordinary. A safe and effective therapy to rescue cones in individuals with RP would mean that precious central vision could be preserved, and complete blindness averted. This would clearly be a major medical breakthrough. This project aims to produce a pre-clinical suite of data that supports the proof-of-concept stage and provides a foundation for effective commercialization by further optimizing the laser’s protective effectneuroprotective efficacy and investigating the mechanism(s) of action on cone photoreceptor survivals in laboratory models.in vitroand in animal models
Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS
Research project start: Semester 1 and 2
Special requirements: Nil
Research Project 5 - Bringing Space Technology to the Eye: Fluoresence Hyperspectral Imaging of Real-time Retinal Eneregy Metabolism
Project description: Drawing on ideas from space technology, we have designed and built a novel, affordable retinal imaging device that uses visible light to obtain functional information from the retina at the molecular level. Our device utilizes fluorescence hyperspectral imaging (fHSI) and novel “big data” analysis to detect subtle changes in cellular energy metabolism.1-4 Our innovative approach is perfectly suited to ophthalmic translation and elegantly solves a key problem in eye health care: non-invasive, real-time measurement of retinal metabolism. This has the potential for a paradigm shift in clinical practice. It is ideally suited for the management of glaucoma, where energy insufficiency accompanying neurodegeneration and mitochondrial dysfunction is a likely key driver of pathogenesis. Our highly focussed research strategy provides a powerful scientific foundation for clinical translation by first mapping the fHSI data to pathological changes in experimental glaucoma. We will then obtain fHSI data from healthy and glaucomatous individuals and map these data to the experimental results. This approach optimizes interpretation of the clinical data and paves the way for future widespread clinical application.
Projects available for: Honours / HDR / Masters / Mphil
Location: AHMS
Research project start: Semester 1 and 2
Special requirements: Nil
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Appointments
Date Position Institution name 2011 - ongoing Director of the Ophthalmic Research Laboratory University of Adelaide 2004 - ongoing Consultant Ophthalmologist Royal Adelaide Hospital -
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Teaching Award Trainer of Excellence Royal Austarlain and New Zealand College of Ophthalmologists Australia - 2013 Teaching Award Trainer of Excellence Royal Australian and New Zealand College of Ophthalmologists Australia - 2007 Award Hanson Institute’s New Clinical Science Investigator Award - - - 2007 Award World Glaucoma Association Young Clinician Scientist Award - - - 2006 Award Pfizer Neuroscience - - - 2001 Scholarship British Government Scholarship - - - 1999 Award Alcon Fellowship - - - -
Education
Date Institution name Country Title 2007 - 2012 University of Adelaide Australia Master of Biostatistics 2001 - 2004 University of Oxford UK DPhil 1986 - 1991 University of Adelaide Australia MB,BS (Hons) -
Certifications
Date Title Institution name Country 2003 GAICD Australian Institute of Company Directors - 2000 FRANZCO Royal Australian and New Zealand College of Ophthalmologists - -
Research Interests
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Journals
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Conference Papers
Year Citation 2022 Patel, C., Tan, Y., Nygaard, S., Guo, B., Carrillo, C., Burgess, J., . . . Casson, R. (2022). Prevalence of refractive error in urban and rural Laos - Vientiane Eye Study. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 897-898). WILEY. 2022 Casson, R. J., Chidlow, G., Chan, W., & Wood, J. (2022). Characterisation of cone photoreceptors in a rat model of retinal detachment. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 950-951). WILEY. 2022 Pham, R., Marshall, H., Kolovos, A., Qassim, A., Mullany, S., Saks, D., . . . Palmer, L. J. (2022). Associations between deep learning segmented macular optical coherence tomography cell layer thicknesses and primary open-angle glaucoma outcomes in the PROGRESSA study. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 913-914). WILEY. 2022 Berry, E. C., Marshall, H. N., Mullany, S., Knight, L. S. W., Hollitt, G., Nguyen, T. T., . . . Craig, J. E. (2022). Lower nocturnal basal SpO(2) is associated with progression in early stage primary open-angle glaucoma. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 853). WILEY. 2022 Marshall, H. N., Han, X., Mullany, S., Qassim, A., Berry, E. C., Hassall, M. M., . . . Craig, J. E. (2022). A cardiovascular disease polygenic risk score predicts macular ganglion cell inner plexiform layer progression in primary open angle glaucoma. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 853-854). WILEY. 2022 Mullany, S., Marshall, H., Gharahkhani, P., Hassall, M. M., Knight, L. S. W., Berry, E. C., . . . Craig, J. E. (2022). The apolipoprotein E4 allele is associated with structural markers of primary open-angle glaucoma disease progression in the PROGRESSA cohort. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 851-852). WILEY. 2022 Marshall, H. N., Mullany, S., Han, X., Qassim, A., Berry, E. C., Nguyen, T., . . . Craig, J. E. (2022). Hyperlipidemia predicts structural and functional disease progression in primary open-angle glaucoma. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 916). WILEY. 2022 Goel, R., Bahrami, B., Macri, C., Casson, R., & Chan, W. (2022). Assessing the subjective quality of smartphone anterior segment photography. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 49 (pp. 892-893). WILEY. 2022 Bourne, R. R. A., Bottone, M., Steinmetz, J., Briant, P., Flaxman, S., Casson, R., . . . Taylor, H. R. (2022). A global and regional analysis of Risk Factors for Blindness and Vision impairment in 2020 and their contribution to the change in prevalence of vision loss over 3 decades. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 63 (pp. 3 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2022 Macri, C., Teoh, I., Bacchi, S., Tan, I., Casson, R., Sun, M., . . . Chan, W. (2022). Automated disease registry using low-code natural language processing. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 50 (pp. 945). WILEY. 2022 Marupally, A. G., Habibalahi, A., Anwer, A. G., Carnt, N. A., White, A. J. R., Casson, R., & Goldys, E. M. (2022). Non-invasive Detection of Glycolytic Stress-induced Reactive Oxygen Species in Human Retinal Pigment Epithelium Cells using Autofluorescence Multispectral Imaging. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 63 (pp. 3 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2021 Marshall, H., Mullany, S., Qassim, A., Han, X., Hassall, M., Nguyen, T., . . . Craig, J. E. (2021). Hypercholestolaemia predicts disease progression in primary open-angle glaucoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 62 (pp. 4 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2021 Bourne, R. R. A., Lansingh, V., Ehrlich, J., Steinmetz, J. D., Briant, P. S., Casson, R., . . . Taylor, H. R. (2021). Burden of Global Vision Loss due to Glaucoma: Temporal and Regional Changes 2000-2020. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 62 (pp. 3 pages). ELECTR NETWORK: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2021 Watson, S., Casson, R., Tay-Kearney, M. -L., Daniels, E., Strem, B., Giles, P., . . . Daniell, M. (2021). Acute Adenoviral Conjunctivitis Treatment: A Phase 2 Interim Analysis of OKG-0301. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 62 (pp. 3 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2018 Ao, J. Z. J., Chidlow, G., Wood, J. P. M., & Casson, R. J. (2018). Evaluation of the safety of laser-delivered Photobiomodulation and its neuroprotection efficacy in a mouse model of Retinitis Pigmentosa. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 59 (pp. 2 pages). Honolulu, HI: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
WoS12018 Ao, J., Chidlow, G., Wood, J., & Casson, R. (2018). NEUROPROTECTION EFFICACY OF LASER-DELIVERED PHOTOBIOMODULATION IN A SEVERE MOUSE MODEL OF RETINITIS PIGMENTOSA. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 46 (pp. 129-130). WILEY. 2018 Guymer, C., Damp, L., Chidlow, G., Wood, J., Tang, E., & Casson, R. (2018). IMPROVE YOUR RESEARCH PRODUCTIVITY WHILST ON YOUR COFFEE BREAK: HIGHLY ACCURATE FULLY-AUTOMATED BATCH PROCESSING TO QUANTIFY RETINAL GANGLION CELLS IN RETINAL FLATMOUNTS. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 46 (pp. 68). WILEY. 2018 Ao, J., Chidlow, G., Wood, J., & Casson, R. (2018). SELECTIVE INHIBITION OF CALPAIN-2 PROTECTS RETINAL GANGLION CELLS AND THEIR FUNCTION IN RETINAL ISCHAEMICREPERFUSION INJURY. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 46 (pp. 37-38). WILEY. 2018 Qassim, A., Mark, H., Han, X., Marshall, H., Graham, S., Healey, P., . . . Craig, J. (2018). CLINICAL UTILITY OF POLYGENIC RISK SCORE IN EARLY GLAUCOMA: APPLICATION IN A NATIONAL PROSPECTIVE EARLY MANIFEST GLAUCOMA COHORT. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 46 (pp. 65). WILEY. 2018 Hassall, M. M., Qassim, A., Han, X., Souzeau, E., Goldberg, I., Healey, P. R., . . . Craig, J. E. (2018). A POLYGENIC RISK SCORE THAT PREDICTS FAMILIAL GENETIC RISK IN GLAUCOMA. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 46 (pp. 64-65). WILEY. 2018 Akkach, S., Andrew, N. H., & Casson, R. J. (2018). AQUEOUS OUTFLOW RESISTANCE AND ITS RELEVANCE TO MICRO-INVASIVE GLAUCOMA SURGERY. In CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY Vol. 46 (pp. 98-99). WILEY. 2016 Wood, J. P. M., Chidlow, G., & Casson, R. J. (2016). Relative susceptibility of individual neuron classes to different insults in rat retinal cultures. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 57 (pp. 2 pages). Seattle, WA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2016 Kokavec, J., Min, S. H., Tan, M. H., Gilhotra, J. S., Newland, H. S., Durkin, S. R., & Casson, R. J. (2016). A Biochemical Analysis of the Living Human Vitreous. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 57 (pp. 2 pages). Seattle, WA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2016 Chidlow, G., Casson, R. J., & Wood, J. P. M. (2016). Investigation into the Short-Term Safety of Localized Re-Treatment of the Retina with a Short Pulse Duration (3-Nanosecond) Laser. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 57 (pp. 2 pages). Seattle, WA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2015 Wood, J. P., Chidlow, G., Tahmasebi, M., Plunkett, M., & Casson, R. J. (2015). RESPONSE OF THE RETINAL PIGMENTED EPITHELIUM TO RETINAL REGENERATION THERAPY (2RT) LASER, IN VITRO AND IN VIVO. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 56 (pp. 2 pages). Denver, CO: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2014 Tahmasebi, M., Casson, R. J., Chidlow, G., Wood, J. P. M., & Plunkett, M. J. (2014). The response of the retinal pigmented epithelium to a novel, nanosecond laser, in vivo: comparison with a conventional continuous wave laser. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2014 Narayan, D., Casson, R. J., Ebneter, A., Chidlow, G., Grace, P. M., Hutchinson, M. R., & Wood, J. P. M. (2014). Immune priming and experimental glaucoma: The effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55 (pp. 7 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2014 Han, G., Casson, R., Wood, J. P. M., & Chidlow, G. (2014). The Mitochondrial Complex I Inhibitor, Rotenone, Induces Endoplasmic Reticulum Stress and Activation of GSK-3 beta in Cultured Rat Retinal Cells. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 55 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2013 Craig, J., Hewitt, A., Graham, S., Healey, P., Casson, R., Mitchell, P., . . . Burdon, K. (2013). Identification of further novel genome wide significant loci for open angle glaucoma blindness utilizing the Australian and New Zealand Registry of Advanced Glaucoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 54 (pp. 3 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
WoS22013 Casson, R., Chidlow, G., Ebneter, A., Han, G., Gilhotra, J., & Wood, J. (2013). Glucose-induced Temporary Visual Recovery in Human Glaucoma: A Prospective, Double-blind, Randomised Study. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 54 (pp. 3 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2013 Wood, J., Chidlow, G., Casson, R., Sharma, S., Burdon, K., & Craig, J. (2013). HUMAN OCULAR DISTRIBUTION OF PRODUCTS OF THE POAG-ASSOCIATED CDKN2B-AS1 GENE CLUSTER REGION. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 54 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2011 Chidlow, G., Wood, J., Ebneter, A., & Casson, R. (2011). Evaluation of Axonal Regeneration in a Rat Model of Experimental Glaucoma. In ARVO 2011 Annual Meeting - Abstracts by Scientific Section/Group - Glaucoma (GL) Vol. 52 (pp. 2453). 12300 Twinbrook Parkway, Rockville, USA, Md, 20852-1606: Assoc Research Vision Ophthalmology Inc. 2010 Chidlow, G., Ebneter, A., Holman, M. C., Wood, J. P., & Casson, R. (2010). Axonal Transport Disruption at the Optic Nerve Head: Comparison Between Rat Models of Retinal Ganglion Cell Degeneration and Utility of the Novel Marker Interleukin-6. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 51 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2010 Holman, M. C., Casson, R., Ebneter, A., Wood, J. P., & Chidlow, G. (2010). Differential Expression of Inducible Heat Shock Proteins in the Rat Retina, Optic Nerve and Brain in Models of Neuronal Degeneration. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 51 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2010 Casson, R. J., Raymond, G., Newland, H. S., Gilhotra, J., Gray, T., Runciman, J., . . . Plunkett, M. (2010). A Pilot, Prospective, Randomized Clinical Trial of a New Nanopulse Retinal Laser versus Conventional Photocoagulation for the Treatment of Diabetic Macular Edema. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 51 (pp. 3 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
WoS12010 Ebneter, A., Chidlow, G., Wood, J. P. M., & Casson, R. J. (2010). Hyperglycemia is Neuroprotective in a Rat Model of Experimental Glaucoma. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 51 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2010 Wood, J. P., Chidlow, G., Mammone, T., & Casson, R. J. (2010). Characteristics of Growth and Death of Adult Rat Retinal Ganglion Cells in Culture. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 51 (pp. 2 pages). ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2004 Osborne, N. N., Wood, J. P. M., Chidlow, G., Casson, R., DeSantis, L., & Schmidt, K. G. (2004). Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities: Relevance to glaucoma. In Brain Research Bulletin Vol. 62 (pp. 525-528). San Antonio, TX: PERGAMON-ELSEVIER SCIENCE LTD.
Scopus48 WoS44 Europe PMC282003 Osborne, N. N., Chidlow, G., Wood, J., & Casson, R. (2003). Some current ideas on the pathogenesis and the role of neuroprotection in glaucomatous optic neuropathy.. In European journal of ophthalmology Vol. 13 Suppl 3 (pp. S19-S26). UNIV ROME, ROME, ITALY: WICHTIG EDITORE.
Scopus22 WoS18 Europe PMC132003 Chidlow, G., Casson, R. J., Vidal-Sanz, M., & Osborne, N. N. (2003). Optic nerve transection provides histological and functional protection to photoreceptors from light damage: Correlation with trophic factor levels. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 44 (pp. U716). FT LAUDERDALE, FLORIDA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2003 Casson, R. J., Chidlow, G., Wood, J. P. M., & Osborne, N. N. (2003). Hyperglycemia protects against retinal ischemia. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 44 (pp. U80). FT LAUDERDALE, FLORIDA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2002 Chidlow, G., Casson, R., Vidal-Sanz, M., Bron, A. J., & Osborne, N. N. (2002). The effect of optic nerve transection on the levels of defined messenger RNA species and the amplitude of the flash electroretinogram in the rat retina. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 43 (pp. U1160). FT LAUDERDALE, FLORIDA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. -
Conference Items
Year Citation 2022 Marshall, H., Han, X., Mullany, S., Hollitt, G., Berry, E. C., Knight, L., . . . Craig, J. E. (2022). High polygenic risk is associated with earlier treatment initiation and escalation in glaucoma suspects. Poster session presented at the meeting of Abstracts of the Association for Research in Vision & Ophthalmology 2022 Annual Meeting (ARVO), as published in Investigative Ophthalmology & Visual Science. Denver, CO, USA & online: Association for Research in Vision & Ophthalmology. 2022 Mullany, S., Marshall, H., Souzeau, E., Hassall, M., Agar, A., Galanopoulos, A., . . . Craig, J. E. (2022). The APOE E4 allele is associated with faster rates of mGCIPL thinning in the PROGRESSA cohort. Poster session presented at the meeting of Abstracts of the Association for Research in Vision & Ophthalmology 2022 Annual Meeting (ARVO), as published in Investigative Ophthalmology & Visual Science. Denver, CO, USA & online: Association for Research in Vision & Ophthalmology. 2022 Berry, E. C., Marshall, H., Mullany, S., Torres, S. D., Schmidt, J., Thomson, D., . . . Craig, J. E. (2022). Greater physical activity is associated with neuroretinal thinning in glaucomatous and normative cohorts. Poster session presented at the meeting of Abstracts of the Association for Research in Vision & Ophthalmology 2022 Annual Meeting (ARVO), as published in Investigative Ophthalmology & Visual Science. Denver, CO, USA & online: Association for Research in Vision & Ophthalmology. 2022 Siggs, O., Qassim, A., Han, X., Marshall, H., Mullany, S., Souzeau, E., . . . Craig, J. (2022). A polygenic risk score predicts functional progression in early primary open-angle glaucoma. Poster session presented at the meeting of Abstracts of the Association for Research in Vision & Ophthalmology 2022 Annual Meeting (ARVO), as published in Investigative Ophthalmology & Visual Science. Denver, CO, USA & online: Association for Research in Vision & Ophthalmology. 2020 Hui, F., Tang, J., Williams, P., McGuinness, M., Hadoux, X., Casson, R. J., . . . Crowston, J. G. (2020). Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial. Poster session presented at the meeting of Abstracts of the Association for Research in Vision & Ophthalmology 2020 Annual Meeting (ARVO), as published in Investigative Ophthalmology & Visual Science. Baltimore: Association for Research in Vision & Ophthalmology.
WoS12019 Mammone, T., Chidlow, G., Casson, R. J., & Wood, J. P. M. (2019). Identification of tau protein kinases in mixed rat retinal cell cultures. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Vancouver, CANADA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2019 Marshall, H. N., Andrew, N. H., Souzeau, E., Ridge, B., Fitzgerald, J., Awadalla, M., . . . Craig, J. E. (2019). Peripapillary RNFL loss precedes Macular GCIPL loss in glaucoma with lower intraocular pressure. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Vancouver, CANADA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2019 Craig, J. E., Qassim, A., Han, X., Hassall, M., Casson, R. J., Graham, S. L., . . . MacGregor, S. (2019). A glaucoma polygenic risk score strongly associated with disease prediction and treatment intensity. Poster session presented at the meeting of Investigative Ophthalmology and Visual Science. Vancouver, Canada: Association for Research in Vision and Ophthalomology. 2019 Qassim, A., Hassall, M., Han, X., Marshall, H. N., Awadalla, M. S., Graham, S. L., . . . Craig, J. E. (2019). Glaucoma polygenic risk score predicts treatment intensity and RNFL loss in glaucoma suspects. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Vancouver, CANADA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2019 Wood, J. P. M., Chidlow, G., Mammone, T., & Casson, R. J. (2019). Glucose protects cultured retinal cells from oxidative injury via pentose phosphate pathway activation and maintenance of reduced glutathione. Poster session presented at the meeting of Investigative Ophthalmology & Visual Science. Vancouver, Canada: Association for Research in Vision and Ophthalmology. 2019 Casson, R. J., Guymer, C., Chidlow, G., Wood, J. P. M., & Damp, L. (2019). Highly Accurate, Fully-Automated Batch Processing of Retinal Ganglion Cell Counts from Retinal Flatmounts. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Vancouver, CANADA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2019 Chidlow, G., Chan, W., Wood, J. P., & Casson, R. J. (2019). The responses of cone photoreceptors to retinal detachment in the rat. Poster session presented at the meeting of Investigative Ophthalmology & Visual Science. Vancouver, Canada: Association for Research in Vision and Ophthalmology. 2019 Qassim, A., Walland, M., Landers, J., Graham, S., Healey, P. R., Agar, A., . . . Craig, J. E. (2019). The effect of phacoemulsification cataract surgery on intraocular pressure in early glaucoma: a prospective multi-site study. Poster session presented at the meeting of Abstracts of the Royal Australian and New Zealand College of Ophthalmologists 51st Annual Scientific Congress, as published in Clinical and Experimental Ophthalmology. Sydney: Wiley.
2019 Marshall, H., Andrew, N., Hassall, M., Qassim, A., Souzeau, E., Ridge, B., . . . Craig, J. E. (2019). Systemic vascular risk factors and IOP determine the location of initial structural and functional deficit in early glaucoma. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2019 Siggs, O., Souzeau, E., Han, X., Qassim, A., Ruddle, J., Vincent, A., . . . Craig, J. (2019). The relative impact of monogenic and polygenic risk variants on age at glaucoma diagnosis. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2019 Hassall, M., Guei-Sheung, L., Teresa, M., John, W., Ao, J., Hewitt, A., . . . Chidlow, G. (2019). Pronase E improves gene transduction of retinal ganglion cells. Poster session presented at the meeting of Abstracts of the Royal Australian and New Zealand College of Ophthalmologists 51st Annual Scientific Congress, as published in Clinical and Experimental Ophthalmology. Sydney: WILEY.
2019 Craig, J., Han, X., Qassim, A., Hassall, M., Casson, R., Graham, S., . . . MacGregor, S. (2019). Multitrait analysis of glaucoma, intraocular pressure and vertical cup to disc ratio identifies many new loci and enables a polygenic genetic risk score strongly predictive of disease susceptibility in the population, and disease progression and treatment intensity in the clinic. Poster session presented at the meeting of Abstracts of the Royal Australian and New Zealand College of Ophthalmologists 51st Annual Scientific Congress, as published in Clinical and Experimental Ophthalmology. Sydeny: WILEY.
2018 Mammone, T., Chidlow, G., Casson, R. J., & Wood, J. P. (2018). Expression and activation of SAPK/JNK in the ONH in a rat model of ocular hypertension. Poster session presented at the meeting of Abstract as published in, Investigative Ophthalmology & Visual Science. Honolulu, Hawaii: Association for Research in Vision and Ophthalmology. 2018 Marshall, H., Andrew, N., Souzeau, E., Ridge, B., Fitzgerald, J., Awadalla, M., . . . Craig, J. (2018). MACULAR GCIPL LOSS PRECEDES PERIPAPILLARY RNFL LOSS IN GLAUCOMA WITH LOWER INTRAOCULAR PRESSURES. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2018 Chidlow, G., Wood, J. P., & Casson, R. (2018). Expression and distribution of mitochondria, glycolytic isoenzymes and lactate transporters in the avascular retina: implications for retinal metabolism. Poster session presented at the meeting of Abstract as published in, Investigative Ophthalmology & Visual Science. Honolulu, Hawaii: Association for Research in Vision and Ophthalmology. 2018 Casson, R., Wood, J. P., & Chidlow, G. (2018). Expression and distribution of mitochondria, glycolytic enzymes, lactate dehydrogenase isoenzymes and lactate transporters in the vascular retina. Poster session presented at the meeting of Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2018), as published in Investigative Ophthalmology & Visual Science. Honolulu, HI: Association for Research in Vision and Ophthalmology. 2018 Craig, J. E., Hewitt, A. W., Mackey, D., Graham, S. L., Healey, P. R., White, A. J., . . . MacGregor, S. (2018). 119 loci influencing intraocular pressure provide new insight into primary open angle glaucoma susceptibility and age of onset. Poster session presented at the meeting of Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2018), as published in Investigative Ophthalmology & Visual Science. Honolulu, HI: Association for Research in Vision and Ophthalmology. 2018 Wood, J. P., Chidlow, G., Guymer, C., Mammone, T., & Casson, R. J. (2018). Pyruvate protects retinal neurones in culture from nutrient deprivation, excitotoxicity and oxidative stress. Poster session presented at the meeting of Abstract as published in, Investigative Ophthalmology & Visual Science. Honolulu, Hawaii: Association for Research in Vision and Ophthalmology. 2018 Guymer, C., Chidlow, G., Wood, J. P., & Casson, R. J. (2018). Oral pyruvate supplementation protects against neurodegeneration in a rat model of glaucoma. Poster session presented at the meeting of Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2018), as published in Investigative Ophthalmology & Visual Science. Honolulu, HI: Association for Research in Vision and Ophthalmology. 2017 Abedi, F., Kolovos, A., Waldie, A., Fitzgerald, J., Awadalla, M., Casson, R., . . . Craig, J. (2017). Corneal deformation dynamics are associated with the retinal nerve fiber layer progression rate in glaucoma suspects and early manifest glaucoma patients. Poster session presented at the meeting of Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2017), as published in Investigative Ophthalmology & Visual Science. Baltimore, MD: Association for Research in Vision and Ophthalmology. 2017 Craig, J. E., Gharahkhani, P., Hewitt, A., Mackey, D., Souzeau, E., Landers, J., . . . Macgregor, S. (2017). FIVE NEW RISK LOCI FOR PRIMARY OPEN ANGLE GLAUCOMA IDENTIFIED USING A NOVEL METHOD: EXTREME PHENOTYPE AND QUANTITATIVE TRAIT LOCUS (EPAQ) MAPPING. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2017 Guymer, C., Chidlow, G., Wood, J., & Casson, R. (2017). ORAL PYRUVATE SUPPLEMENTATION PROTECTS AGAINST GLAUCOMATOUS NEURODEGENERATION IN RATS.. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2017 Marsha, H., Andrew, N., Agar, A., Graham, S., Galanopoulos, A., Healey, P., . . . Craig, J. (2017). COMPARISON OF TREND-BASED PROGRESSION ANALYSIS USING MACULAR GANGLION CELL-INNER PLEXIFORM LAYER (GCIPL) LOSS AND PERIPAPILLARY RETINAL NERVE FIBRE LAYER (RNFL) LOSS IN GLAUCOMA: RESULTS FROM A PROSPECTIVE LONGITUDINAL STUDY (THE PROGRESSA STUDY). Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2017 Ao, J., Chidlow, G., Wood, J., & Casson, R. (2017). A SAFETY STUDY OF PHOTOBIOMODULATORY FAR RED/NEAR-INFRARED LASER. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY. 2016 Harpas, Y., Wood, J. P. M., Chidlow, G., & Casson, R. J. (2016). Red/Near-infrared irradiation therapy (R/NIR IT) LASER pretreatment promotes neuroprotection of retinal neurons in a model of retinal metabolic dysfunction in vitro.. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Seattle, WA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2016 Sia, P. I., Wood, J. P. M., Chidlow, G., & Casson, R. J. (2016). Creatine protects rat retinal neurons in an in vitro model of metabolic compromise. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Seattle, WA: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2016 Narayan, D., Chidlow, G., Wood, J. P., & Casson, R. J. (2016). Bio-energetic preservation of cones in a mouse model of retinitis pigmentosa. Poster session presented at the meeting of Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2016), as published in Investigative Ophthalmology & Visual Science. Seattle, WA: Association for Research in Vision and Ophthalmology.
2016 Sun, M., O'Connor, A., Wood, J., Casson, R., Milne, I., Biswa, D., & Selva, D. (2016). BIOENGINEERING EYELID TARSUS. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2016 Kokavec, J., Horo, S., Gilhotra, J., Newland, H., Durkin, S., & Casson, R. (2016). VITREOUS TISSUE BANKING: KEEPING A LID ON CONTAMINANTS. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2016 Narayan, D., Chidlow, G., Wood, J., & Casson, R. (2016). Bio-energetic preservation of cones in a mouse model of retinitis pigmentosa. Poster session presented at the meeting of Abstracts of the Royal Australian and New Zealand College of Ophthalmologists, 48th Annual Scientific Congress, as published in Clinical and Experimental Ophthalmology. Melbourne, Vic.: Wiley-Blackwell.
2016 Chehade, L., & Casson, R. (2016). NANOSECOND LASERS: A REVIEW. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2016 Zhou, T., Souzeau, E., Sharma, S., Siggs, O., Goldberg, I., Healey, P., . . . Craig, J. (2016). COMPREHENSIVE GENETIC ANALYSIS OF KNOWN MENDELIAN GENES IN EARLY ONSET ADVANCED POAG. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2016 Wood, M., Sun, M., Chan, W., & Casson, R. (2016). PRESSURES GENERATED DURING CORNEAL WOUND HYDRATION. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Chidlow, G., Wood, J. P., Knoops, B., & Casson, R. J. (2015). Expression and distribution of peroxiredoxins in the retina and optic nerve. Poster session presented at the meeting of Abstracts of the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2015), as published in Investigative Ophthalmology & Visual Science. Denver, CO: The Association for Research in Vision and Ophthalmology.
2015 Casson, R. J., Chidlow, G., Han, G., Kittipassorn, T., Peet, D., & Wood, J. P. (2015). Pyruvate Kinase and Lactate Dehydrogenase lsoenzymes in Mammalian Retina: Novel Metabolic Implications. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Denver, CO: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2015 Sia, P., Wood, J., Chidlow, G., & Casson, R. (2015). Creatine Protects Cultured Rat Retinal Neurons in a Model of Metabolic Compromise. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Harpas, Y., Wood, J., Casson, R., Chidlow, G., & Previn, V. (2015). PHOTOBIOMODULATION OF THE RETINA. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Narayan, D., Chidlow, G., Wood, J., & Casson, R. (2015). TEMPORAL AND SPATIAL CHARACTERISATION OF CONE DEGENERATION IN A MOUSE MODEL OF RETINITIS PIGMENTOSA. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Fitzgerald, J., Usher, B., Landers, J., Casson, R., Galanopoulos, A., Graham, S., . . . Craig, J. (2015). Using Cirrus Hd-Oct Ganglion Cell Analysis to Measure Progression of Disease in Glaucoma Suspects and Early Manifest Glaucoma: Progressa Study Data. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Fitzgerald, J., Usher, B., Landers, J., Casson, R., Galanopoulos, A., Graham, S., . . . Craig, J. (2015). SENSITIVITY AND SPECIFICITY OF THE GANGLION CELL ANALYSIS FOR CIRRUS HD-OCT USING DATA FROM PROGRESSA STUDY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Kokavec, J., Min, S. H., Tan, M. H., Gilhotra, J. S., Newland, H., Durkin, S., & Casson, R. (2015). THE CHEMISTRY OF HUMAN VITREOUS HUMOR IN-VIVO. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2015 Mammone, T., Chidlow, G., Casson, R. J., & Wood, J. P. (2015). Activation of P42/44 MAPK inthe optic nerve head in an experimental rat model of glaucoma. Poster session presented at the meeting of INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. Denver, CO: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2014 Sun, M., Pham, D., O'Connor, A., Wood, J., Casson, R., Selva, D., & Costi, J. (2014). THE BIOMECHANICS OF EYELID TARSUS TISSUE. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2014 Craig, J., Burdon, K., Gharahkhani, P., Hewitt, A., Mackey, D., Mitchell, P., . . . Macgregor, S. (2014). GENOME WIDE ASSOCIATION STUDY IN THE AUSTRALIAN AND NEW ZEALAND REGISTRY OF ADVANCED GLAUCOMA IDENTIFIES COMMON SEQUENCE VARIANTS IN ABCA1, AFAP1 AND GMDS WHICH CONFER RISK OF PRIMARY OPEN-ANGLE GLAUCOMA, AND REPLICATE IN MULTIPLE INDEPENDENT COHORTS. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2014 Fitzgerald, J., Usher, B., Landers, J., Casson, R., Galanopoulos, A., Graham, S., . . . Craig, J. (2014). MACULAR PATHOLOGY AND IMAGING ARTEFACT AFFECTING RETINAL GANGLION CELL COMPLEX ANALYSIS RESULTS USING CIRRUS HD-OCT IN GLAUCOMA SUSPECTS AND EARLY GLAUCOMA PATIENTS: RESULTS FROM PROGRESSA STUDY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2013 Casson, R. J. (2013). GLUCOSE-INDUCED TEMPORARY VISUAL RECOVERY IN HUMAN GLAUCOMA: A PROSPECTIVE, DOUBLE-BLIND, RANDOMIZED STUDY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2013 Andrew, N., Wood, J., Mammone, T., Chen, A., Pirbhai, A., Casson, R., & Selva, D. (2013). A PROTOCOL FOR GROWING HUMAN ORBITAL FIBROBLAST CULTURES IN VITRO. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2013 Fitzgerald, J., Usher, B., Craig, J., Landers, J., Casson, R., Graham, S., . . . Healey, P. (2013). BASELINE DATA OF PATIENTS ENROLLED IN PROGRESSA STUDY : GLAUCOMA SUSPECT AND EARLY MANIFEST GLAUCOMA PROGRESSION TRIAL. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2012 Narayan, D., Wood, J., Ebneter, A., Chidlow, G., Grace, P., Hutchinson, M., & Casson, R. (2012). IMMUNE PRIMING AND EXPERIMENTAL GLAUCOMA: THE EFFECT OF PRIOR SYSTEMIC LIPOPOLYSACCHARIDE CHALLENGE ON TISSUE OUTCOMES AFTER OPTIC NERVE INJURY. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2011 Casson, R., Kahawita, S., Visonnavong, V., Sisaleumsak, S., & Muecke, J. (2011). EXCEPTIONALLY LOW PREVALENCE OF REFRACTIVE ERROR AND VISUAL IMPAIRMENT IN SCHOOLCHILDREN FROM A RAPIDLY URBANIZING REGION OF SOUTHEAST ASIA. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2011 Crane, G. J., Karnon, J., Kymes, S., Casson, R., Metcalfe, A., & Hiller, J. E. (2011). A DISCRETE EVENT SIMULATION TO OPTIMISE THE ALLOCATION OF CONSTRAINED HOSPITAL RESOURCES FOR GLAUCOMA. Poster session presented at the meeting of VALUE IN HEALTH. ELSEVIER SCIENCE INC.
WoS22011 Shibeeb, O., Chidlow, G., Wood, J. P. M., & Casson, R. J. (2011). RAT RETINAL RESPONSES TO TREATMENT WITH A PHOTOCOAGULATOR LASER AND A NANOSECOND PULSE LASER. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL. 2011 Han, G., Wood, J., Chidlow, G., Casson, R., & Mammone, T. (2011). MECHANISMS OF GLUCOSE PROTECTION OF CULTURED RAT RETINAL CELLS FROM EXPERIMENTAL ANOXIA. Poster session presented at the meeting of CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. WILEY-BLACKWELL.
NHMRC Project Grants 2008-2016
2016-2019 Robert Casson; Dan Peet; Glyn Chidlow; John Wood; 1099932 Novel Photoreceptor Bioenergetics: Basic Science and Clinical Translation $724 500
2016 -2019 Robert Casson; Jonathan Crowston; Glyn Chidlow; John Wood 1102568 Retinal Ganglion Cell Bioenergetics with Clinical Translation $710500
2012-2016 1009844 Ecosse Lamoureux; Jonathan Crowston; Robert Casson; Ivan Goldberg Comparing the Effectiveness of Selective Laser Trabeculoplasty with Topical Medication For The Treatment of Primary Open Angle Glaucoma: $614240
2010-2012 626964 Robert Casson; John Wood; Glyn Chidlow, Jonathan Crowston; Ian Trounce: 2010-2012 How does glucose protect the retina and optic nerve against ischaemia? $402,875
2010-2011 627130 Jonathan Karnon; Robert Casson; Janet Hiller; Andrew Metcalfe: 2010-2012 Integrating Health Technology Assessment and Service Delivery and Organisation to Maximise Health Gains $252,050
2009-2011 565202 John P Wood; Glyn Chidlow; Robert Casson: The Role of Tau in the Pathological Retina $360,750 2009-2011
2008-2010 508123 Glyn Chidlow; John Wood; Robert Casson Role of Osteopontin in ischemic-like injury to the retina $343,313
Ophthalmic Research Institute of Australia Grants 2010-2015
- ORIA 2011: Can topical glucose improve contrast sensitivity in glaucoma patients?: $48,000
- ORIA 2012: Undersatnding the Warburg effect in the Retina: $45000
- ORIA 2013: Glucose Induced Retinal Neurorecovery: $35000
- ORIA 2015: Are Glucose Carbon Atoms Required for Rhodopsin Synthesis $38000
Teaching (and related duties) including Supervision
Creation of New Higher Degree at Adelaide University
In August 2007, in consultation with the Faculty of Health Sciences, I drafted and spearheaded a new higher degree by research at Adelaide University: a Masters of Ophthalmology (M.Ophth). It is a 1-2 year full-time degree. A similar degree can only be obtained at a handful of Universities. The draft was reviewed by Professor Justin Beilby (Executive Dean, Faculty of Health Sciences). The completed manuscript was then reviewed by the REDC and after minor amendments was accepted. The first intake of students occurred in 2008; four students enrolled. All students conducted epidemiological-based projects. One international student is in the process of upgrading to a PhD. In 2009, a further two students have enrolled. We are currently limited by the supply of supervisors, not interested students. One student is conducting a clinical project and the other student an ophthalmic genetic epidemiology project. As our research activities expand, I envisage that the Masters of Ophthalmology will become an increasingly popular higher degree for both local and international students. We have a diverse range of appealing projects to offer, including projects with epidemiological field work in South-east Asia, projects involving indigenous Australians, lab-based research and clinical projects. Within 5 years, we aim to have 10-15 students enrolled.
Stimulation of Student Learning and Innovations in Teaching Methods
Only a small portion of the medical student curriculum at Adelaide University is devoted to ophthalmology. I currently organize the 6th-Year Ophthalmology Lecture Series and previously gave 2 lectures, including information about ophthalmology training. I regularly provide one-on-one and small group teaching to 6th-Year elective students in my clinics at the RAH. To increase undergraduate ophthalmic teaching, I instituted a regular 3 hour teaching session in my clinic at the LMHS to provide 6th year medical students with extra theoretical and practical tuition in the most important aspects of ophthalmology, particularly in areas that they are likely to encounter as junior hospital doctors or general practitioners. The student evaluation feedback has been extremely positive (see attached evidence). Many students have found the practical demonstration of the direct ophthalmoscope and the slit lamp particularly useful. In 2010 I altered the 6th year teaching curriculum to include a practical demonstration as part of the lecture series. The feedback again was very positive. Some students asked for some written material; hence, I authored an “ophthalmic survival guide” which I now distribute to students.
Since 2006, I have participated in the 4th Year Research Proposal Programme. I have provided projects for and mentored 5 students during this time. All students received outstanding reports. I have served as an Assessor for 5 students.
In 2011 I re-instituted the 6th-Year Ophthalmology Prize. This takes the form of a $300 book voucher and is awarded to the student with the highest mark in the final Ophthalmology quiz. The students are forewarned that they should study a basic ophthalmology text and atlas of eye disease. A number of students have provided outstanding answers and have clearly done a considerable amount of study.
Honours Programs in School of Medicine
I have successfully supervised three Honours students: Drew Marshall, Yeng Chan, and Daniel Naryan (currently a Masters student). Drew travelled to Sri Lanka with me in 2007 to collect data for the Kandy Eye Study. He subsequently analysed the visual impairment data and has authored a paper in the leading ophthalmic journal. Yeng completed a lab-based Honours project on the effect of Coenzyme Q on retinal excitotoxic injury. Daniel completed a highly successful Honours year in the lab and has returned in 2015 to comlete a Masters in retinal bioenergtics.
I have examined 4 Honours theses.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Co-Supervisor Designing a novel therapeutic CRISPR/Cas9 based strategy towards treating genetic eye disease Master of Philosophy (Medical Science) Master Full Time Mr Lachlan Graham Staker 2022 Co-Supervisor The Development of Novel CRISPR/Cas9 Based Therapies for Genetic Eye Disease Master of Philosophy (Medical Science) Master Full Time Miss Jesse Georgina Kennedy 2022 Principal Supervisor Childhood blindness in the developing world Master of Philosophy (Ophthalmology) Master Full Time Mr Thomas Keats Rogerson 2021 Co-Supervisor Investigating the cellular metabolism of the mammalian retina. Doctor of Philosophy Doctorate Full Time Mr David Sean Hansman 2019 Principal Supervisor Treating choroidal neovascularization with photobiomodulation laser and retinal rejuvenation therapy laser Master of Philosophy (Ophthalmology) Master Full Time Miss Marzieh Tahmasebi Sarvestani -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 - 2022 Principal Supervisor Posterior Corneal Astigmatism Doctor of Philosophy Doctorate Full Time Dr Benjamin Richard Lahood 2017 - 2020 Principal Supervisor Bioenergetic Neuroprotection in Experimental Glaucoma Master of Philosophy (Ophthalmology) Master Part Time Dr Chelsea Suzanne Guymer 2017 - 2019 Principal Supervisor Photobiomodulation Laser in Retinal Degeneration Master of Philosophy (Ophthalmology) Master Full Time Dr Jack Zi Jie Ao 2017 - 2022 Co-Supervisor Molecular Drivers of Aerobic Glycolysis in the Mammalian Retina Doctor of Philosophy Doctorate Full Time Mr Cameron David Haydinger 2015 - 2018 Principal Supervisor Manipulation of Photoreceptor Energy Metabolism for Clinical Advantage Master of Philosophy (Ophthalmology) Master Full Time Mr Daniel Sanju Narayan 2015 - 2018 Principal Supervisor Creatine neuroprotection in the retina Master of Philosophy (Ophthalmology) Master Full Time Dr Paul Ikgan Sia 2014 - 2020 Co-Supervisor Investigating the Warburg effect and the role of pyruvate kinase M2 in retinal Müller glial cells Doctor of Philosophy Doctorate Full Time Miss Thaksaon Kittipassorn 2013 - 2014 Principal Supervisor Characterization of Rat Retinal Responses to a Conventional Retinal Laser and a Novel Short Pulse Duration Laser Master of Philosophy (Ophthalmology) Master Full Time Mr O'Sam Shibeeb 2013 - 2017 Co-Supervisor The Activation of Mitogen-Activated Protein Kinases in the Optic Nerve Head in a Model of Ocular Hypertension Master of Philosophy (Ophthalmology) Master Full Time Miss Teresa Mammone 2013 - 2017 Co-Supervisor Periocular Malignancy and Eyelid Reconstruction Doctor of Philosophy Doctorate Full Time Dr Michelle Tian Sun 2011 - 2014 Co-Supervisor Factors affecting success in endoscopic dacryocystorhinostomy Master of Philosophy (Ophthalmology) Master Full Time APrf Weng Onn Chan 2010 - 2014 Principal Supervisor Aspects of retinal energy metabolism Doctor of Philosophy Doctorate Full Time Mr Guoge Han 2008 - 2010 Principal Supervisor Cataract in a Rural Sri Lankan Population Master of Ophthalmology Master Full Time Mr Paul Athanasiov 2008 - 2011 Principal Supervisor Hyperglycaemia in Experimental Glaucoma Doctor of Philosophy Doctorate Full Time Dr Andreas Johannes Anton Ebneter 2007 - 2016 Principal Supervisor The Effect of Hyperglycaemia on Experimental Subacute Ischaemic Optic Neuropathy and Retinopathy Master of Surgery Master Full Time APrf Matthew Holman 2005 - 2011 Principal Supervisor Aspects of Retinal and Optic Nerve Pathology after Excitotoxic Retinal Injury Doctor of Philosophy Doctorate Part Time Dr Sarabjit Saggu
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Board Memberships
Date Role Board name Institution name Country 2014 - ongoing Chair Ellex medical Advisory Board - - 2009 - ongoing - Sight for All - - -
Committee Memberships
Date Role Committee Institution Country 2010 - ongoing Board Member World Glaucoma Association - - -
Consulting/Advisories
Date Institution Department Organisation Type Country 2015 - ongoing Calpain Therapeutics - - - 2015 - ongoing Ellex Medical Lasers - Business and professional - -
Editorial Boards
Date Role Editorial Board Name Institution Country 2012 - ongoing Board Member Ophthalmic Epidemiology - - 2011 - ongoing Editor-In-chief Clinical and Experimental Ophthalmology - -
Connect With Me
External Profiles