Rajesh Chaudhary

Rajesh Chaudhary

Higher Degree by Research Candidate

Adelaide Medical School

Faculty of Health and Medical Sciences

I am currently a PhD student at SAHMRI through The University of Adelaide. And, my principle supervisor is A/Prof. Leonie Heilbronn. Our group, Diabetes and Metabolism, is currently involved in looking into the effects of timing of nutrition and food intake and type of diet and its overall impact on health -- particularly, on obesity and diabetes.

Type 2 diabetes mellitus (T2DM) has affected more than 400 million people around the world by 2012, according to the World Health Organisation (WHO) and Australia is not spared of this -- almost 1 in 6 Australians are suffering from the T2DM and it is costing approximately more than a billion dollar every year to the Australian government to contain it and treat those who are suffering. Out of several process that feeds into the process of development and progression of T2DM, Autophagy is one of those. Autophagy is basically a cellular process that functions as a housekeeping for a cell besides energy homeostasis and protein recycling and removing the unwanted and denatured proteins. In general term, it is explained as a cellular self-eating process where it eats up the cellular organelles such as misfolded proteins, mitochondria, endoplasmic reticulum, ribosomes etc and generate energy required by the cell specially during the stress conditions, specifically, nutrient deprivation, starvation, hypoxia et cetra. 

Autophagy -- a cellular process.
Autophagy process. Adopted from, Kaur J., Debnath J., Molecular Cell Biology, Nature Reviews, Volume 16, 2015.

Autophagy, besides, having a normal and usual function in housekeeping, it is also involved in regulating insulin resistance in diabetic individuals by maintaining the normal pancreatic beta-cell function by mitigating the oxidative and ER stress through number of pathways. Autophagy also regulates intracellular insulin level by lososomal degradation of secretory granules through a specialised form of autophagy, termed crinophagy (Orci et., 1984). And, crinophagic activity is glucose dependent -- pertaining to the fact that, crinophagy increases with lower plasma glucose concentration and leading to fall in intracellular insulin levels.

Autophagy in diabetes
Acquired from: Adam D. Barlow and David C. Thomas, DNA and Cell Biology, DOI: 10.1089/dna.2014.2755
, Volume 34, Number 4, 2015.

So, here at SAHMRI, we are looking into the mechanism on how intermittent-fasting affect the autophagic process and its effect in insulin resistance, diabetes and obesity and if it related to the telomere dynamics -- a process which is quite prevalent in the diabetes and has now been started to be considered as the marker of diabetes. 

Scientific posters

ANZOS & BREAKTHROUGH DISCOVERIES 2018
JOINT ANNUAL SCIENTIFIC MEETING

 
International Conference in Medicine and Public Health 2012 (ICMPH2012)

 

Poster for ICMPH2012

 

  • Appointments
    Date Position Institution name
    2017 - 2020 PhD Student University of Adelaide, Adelaide
    2016 - 2017 Lecturer Nepalgunj Medical College
    2013 - 2016 Lecturer Kathmandu Medical College and Teaching Hospital, Nepal

  • Language Competencies
    Language Competency
    English Can read, write, speak, understand spoken and peer review
    Hindi Can read, write, speak, understand spoken and peer review
    Maithili Can read, write, speak, understand spoken and peer review
    Nepali Can read, write, speak, understand spoken and peer review

  • Education
    Date Institution name Country Title
    2009 - 2012 Siriraj Hospital, Mahidol University Thailand M.Sc. Biochemistry
    2004 - 2008 Kathmandu University, Kathmandu Nepal Bachelor of Technology in Biotechnology
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