![Rainer Haberberger](/sites/default/files/styles/profile_large/public/profile-images/25907.jpeg?itok=0XjuNE9I)
Professor Rainer Haberberger
Professor
School of Biomedicine
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Professor Rainer Viktor Haberberger is the Wood Jones Chair of Anatomy at The University of Adelaide, where he also heads up the Peripheral Pain Laboratory. Previously he was Professor of Anatomy & Histology, Head of the Pain & Pulmonary Neurobiology, and Convenor of the Centre for Neuroscience at Flinders University. He studied Human Biology (Medical Research) at the Philipps-University in Marburg, Germany and has been a Senior Scientist and Lecturer at the Institute for Anatomy and Cell Biology, Justus-Liebig University Giessen, Germany until 2005.
His main areas of research interest are novel signalling mechanisms in pain transducing cells and how to utilize those to create a “pain-measurement device”. He received the Collaborative Research Grant of the International Society for the Study of Pain (IASP) 2006 & 2010, the Decima Strachan and Claire Lilia Wooton Estates “Spinal Cord Research Award” of the Australian Brain Foundation 2008 and the Australian Lung Foundation “Ludwig Engel Grant-in-Aid” for Physiological Research 2011. In 2017 he was chief investigator of an application that received the “John Boyd Craig Research Award”, Australian and New Zealand College of Anaesthetists.
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Research Summary
Chronic ongoing pain affects millions of people, and similar to cancer, there are different types of pain. Patients suffer for years because available drugs often don’t work very well because they cannot be targeted to a specific pain type. This is because there is no tool available that allows a quick and easy discrimination between pain types. The Peripheral Pain research group looks at reasons why drugs often don’t work that well for people suffering from chronic ongoing pain, what the characteristics of the pain detecting nerve cells in humans are and how we can better predict and define what type of pain people have. This is to support diagnosis and to guide better treatment strategies. The laboratory collaborates with groups across Adelaide to align and complement techniques such as multiple labelling immuno-histochemistry, cell culture, RNASeq, and lipidomics.
Projects are available for: Honours / PhD / Masters
1. Development of a “neuron-on-chip” microfluidic device to differentiate between chronic pain types
A major clinical problem in treating chronic pain is that it is intrinsically difficult to measure because it encompasses both psycho-behavioural and physiological components. Consequently, low-cost and objective methods of pain assessment are not available, and clinical diagnosis relies heavily on self-reporting from patients. Approaches are urgently needed that can identify chronic pain states and discriminate between different subtypes. These would enhance the accuracy and efficiency of clinical diagnosis, design of treatment plans, and monitoring of treatment effectiveness, while minimizing harm and adverse effects associated with treatment.
In collaboration with Dr Matusica, Flinders University and Prof Nico Voelcker at Monash University, this research program will use a combination of neurobiology and nano-material science to more accurately and efficiently assess common chronic pain conditions via analysis of serum. This approach is based on two key innovations. We have determined how to drive immortalised sensory neurons into two major classes of nociceptor-like cells with distinct sensory capacities that can discriminate between serum samples collected from animal and human models of chronic pain using transcriptomics and calcium imaging. We aim to further identify and characterise the capacity of immortalised sensory neurons to specifically respond to serum obtained from different animal models of chronic pain.
In this research we will also incorporate these cells into a microfluidic device utilising novel “neuron-on-chip” technology. This with the aim to create a biosensor device optimised for analysis of serum samples using machine learning to discriminate between human chronic pain subtypes. A device capable of producing a reliable empirical measure of a chronic pain subtype, which we propose here, would revolutionise the speed and accuracy of diagnostic outcomes, especially for patients who are not capable of verbal self-reporting.
2. Development of a cell-type specific map of human dorsal root ganglia (DRG)
In the field of pain research there is a discrepancy between promising treatments using laboratory animals and the number of successful treatment strategies in humans. This is in part related to differences between sensory neurons in humans and animals. Data related to presence and function of nociceptors and other cell types in DRG cannot necessarily be translated from animal studies to the human situation. For example, the separation of nociceptors in two major classes of peptidergic and non-peptidergic cells is not possible for human nociceptors. Human nociceptors have a different neurochemical profile and utilize different sodium channels to generate action potentials. In addition, it is unknown what cell types comprise a human DRG. Consequently, the effect of treatments such as DRG stimulation on the different cell types in human DRGs is unknown as it is also not known how the cells that exist in human DRG change in response to ongoing chronic pain. This renders neurosurgical procedures and treatments to trial and error experiments.
In collaboration with SAHMRI and the Adelaide Microscopy facility, this research project aims to identify and describe the cell types present in human DRG, define neurochemical characteristics and changes in response to chronic pain. Here we will focus at the presence of non-neuronal cell types such as macrophages, T- and B-cells and mast cells, and define the vasculature including lymphatics. In addition we will use latest technology to create the first lipidomics map of human DRG.
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Appointments
Date Position Institution name 2021 - ongoing Wood Jones Chair in Anatomy University of Adelaide 2014 - 2021 Professor of Anatomy & Histology Flinders University 2009 - 2014 Associate Professor for Neuroscience in Anatomy & Histology Flinders University 2005 - 2009 Mary Overton Neuroscience Research Fellow Flinders University 1996 - 2004 Lecturer Technical College Giessen-Friedberg 1996 - 1997 Lecturer at the Institute for Anatomy and Cell Biology Justus-Liebig-University 1995 - 2005 Research Fellow and Senior Lecturer at the Institute for Anatomy and Cell Biology Justus-Liebig-University 1994 - 1995 Scientist and Lecturer at the Institute for Anatomy and Cell Biology Philipps-University 1992 - 1996 Lecturer Medi-Learn Company -
Awards and Achievements
Date Type Title Institution Name Country Amount 2019 Award Teaching Excellence Award Flinders Medical Student Society Australia - 2018 Award Recognition of Exemplary Education Award for the Anatomy and Histology Unit Flinders Medical Student Society Australia - 2017 Award John Boyd Craig Research Award Australian and New Zealand College of Anaesthetists Australia - 2012 Award Bren Gannon Award for Innovation in Teaching Flinders Medical Student Society Australia - -
Education
Date Institution name Country Title 2000 - 2004 Justus-Liebig-University Germany Professorial Degree 1995 - 1998 Philipp University of Marburg Germany Research Doctorate (PhD) in Neuroscience 1988 - 1994 Philipp University of Marburg Germany Diploma Medical Research (Human Biology) -
Postgraduate Training
Date Title Institution Country 2000 - 2003 Postdoctoral Fellowship - Acetylcholine receptors of primary afferent neurons Justus-Liebig-University Germany -
Research Interests
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Journals
Year Citation 2023 Haberberger, R. V., Kuramatilake, J., Barry, C. M., & Matusica, D. (2023). Ultrastructure of dorsal root ganglia. Cell and Tissue Research, 393(1), 17-36.
Scopus5 Europe PMC12022 Castro, J., Harrington, A. M., Chegini, F., Matusica, D., Spencer, N. J., Brierley, S. M., . . . Barry, C. M. (2022). Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia.. Front Cell Infect Microbiol, 11, 1-11.
Scopus4 WoS3 Europe PMC32021 Tran, H. B., Hamon, R., Jersmann, H., Ween, M. P., Asare, P., Haberberger, R., . . . Hodge, S. J. (2021). AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke. Journal of Inflammation-London, 18(1), 1-13.
Scopus10 WoS6 Europe PMC82020 Chia, K. L., Teoh, J. H., & Haberberger, R. V. (2020). Neuroanatomical relationship between Jingbi and the brachial plexus. Acupuncture in Medicine, 39(3), 964528420938373.
2020 Haberberger, R. V., Barry, C., & Matusica, D. (2020). Immortalized Dorsal Root Ganglion Neuron Cell Lines. Frontiers in Cellular Neuroscience, 14, 21 pages.
Scopus35 WoS27 Europe PMC202020 Dusan, M., Jastrow, C., Alyce, M. M., Yingkai, W., Shashikanth, M., Andelain, E., . . . Haberberger, R. (2020). Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes. Molecular Pain, 16, 1-19.
Scopus1 Europe PMC22019 Barry, C. M., Matusica, D., & Haberberger, R. V. (2019). Emerging Evidence of Macrophage Contribution to Hyperinnervation and Nociceptor Sensitization in Vulvodynia. Frontiers in Molecular Neuroscience, 12, 7 pages.
Scopus13 WoS10 Europe PMC82019 Haberberger, R. V., Barry, C., Dominguez, N., & Matusica, D. (2019). Human dorsal root ganglia. Frontiers in Cellular Neuroscience, 13, 17 pages.
Scopus137 WoS112 Europe PMC952019 Jiang, Z. J., Delaney, T. L., Zanin, M. P., Haberberger, R. V., Pitson, S. M., Huang, J., . . . Gong, L. W. (2019). Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells. Journal of Neurochemistry, 149(6), 729-746.
Scopus9 WoS8 Europe PMC72018 Barry, C. M., Ji, E., Sharma, H., Yap, P., Spencer, N. J., Matusica, D., & Haberberger, R. V. (2018). Peptidergic nerve fibers in the urethra: Morphological and neurochemical characteristics in female mice of reproductive age. Neurourology and Urodynamics, 37(3), 960-970.
Scopus12 WoS11 Europe PMC42018 Barry, C. M., Huilgol, K. K., & Haberberger, R. V. (2018). New models to study vulvodynia: Hyperinnervation and nociceptor sensitization in the female genital tract. Neural Regeneration Research, 13(12), 2096-2097.
Scopus5 WoS5 Europe PMC32018 Sharma, H., Ji, E., Yap, P., Vilimas, P., Kyloh, M., Spencer, N. J., . . . Barry, C. M. (2018). Innervation Changes Induced by Inflammation in the Murine Vagina. Neuroscience, 372, 16-26.
Scopus11 WoS8 Europe PMC72018 Gutbier, B., Schönrock, S. M., Ehrler, C., Haberberger, R., Dietert, K., Gruber, A. D., . . . Witzenrath, M. (2018). Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Critical care medicine, 46(3), e258-e267.
Scopus16 WoS14 Europe PMC112017 Quarta, S., Camprubí-Robles, M., Schweigreiter, R., Matusica, D., Haberberger, R. V., Proia, R. L., . . . Kress, M. (2017). Sphingosine-1-phosphate and the S1P<inf>3</inf> receptor initiate neuronal retraction via RhoA/ROCK associated with CRMP2 phosphorylation. Frontiers in Molecular Neuroscience, 10, 13 pages.
Scopus30 WoS27 Europe PMC202017 Barry, C. M., Ji, E., Sharma, H., Beukes, L., Vilimas, P. I., DeGraaf, Y. C., . . . Haberberger, R. V. (2017). Morphological and neurochemical differences in peptidergic nerve fibers of the mouse vagina. Journal of Comparative Neurology, 525(10), 2394-2410.
Scopus9 WoS7 Europe PMC42017 Chia, K. L., & Haberberger, R. V. (2017). Needling depth at BL52 in 13 cadavers. Acupuncture in Medicine, 35(2), 155-156.
Scopus2 WoS2 Europe PMC12017 Barnawi, J., Jersmann, H., Haberberger, R., Hodge, S., & Meech, R. (2017). Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. Respirology, 22(2), 315-321.
Scopus30 WoS27 Europe PMC232017 Rojas-Canales, D., Penko, D., Min, K., Parham, K., Peiris, H., Haberberger, R., . . . Jessup, C. (2017). Local sphingosine kinase 1 activity improves islet transplantation. Diabetes, 66(5), 1301-1311.
Scopus6 WoS6 Europe PMC42016 Tran, H. B., Barnawi, J., Ween, M., Hamon, R., Roscioli, E., Hodge, G., . . . Hodge, S. (2016). Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. Journal of Leukocyte Biology, 100(1), 195-202.
Scopus29 WoS28 Europe PMC232016 Barnawi, J., Tran, H. B., Roscioli, E., Hodge, G., Jersmann, H., Haberberger, R., & Hodge, S. (2016). Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. COPD: Journal of Chronic Obstructive Pulmonary Disease, 13(5), 653-661.
Scopus19 WoS16 Europe PMC162016 Chia, K. L., & Haberberger, R. V. (2016). A study to investigate needle insertion at Shenshu (BL23) to puncture psoas major muscle. Journal of Integrative Medicine, 14(2), 128-133.
Scopus3 WoS3 Europe PMC22016 Weth-Malsch, D., Langeslag, M., Beroukas, D., Zangrandi, L., Kastenberger, I., Quarta, S., . . . Kress, M. (2016). Ablation of sphingosine 1-phosphate receptor subtype 3 impairs hippocampal neuron excitability in vitro and spatial working memory in vivo. Frontiers in Cellular Neuroscience, 10(NOV2016), 12 pages.
Scopus17 WoS12 Europe PMC132015 Beroukas, D., Selhorst, M., Pitson, S. M., Matusica, D., Gibbins, I. L., Kress, M., & Haberberger, R. V. (2015). Sphingosine kinase 1 in murine dorsal root ganglia. AIMS MOLECULAR SCIENCE, 2(1), 22-33.
WoS12015 Kestell, G., Anderson, R., Clarke, J., Haberberger, R., & Gibbins, I. (2015). Primary afferent neurons containing calcitonin gene-related peptide but not substance P in forepaw skin, dorsal root ganglia, and spinal cord of mice. Journal of Comparative Neurology, 523(17), 2555-2569.
Scopus35 WoS32 Europe PMC262015 Canlas, J., Holt, P., Carroll, A., Rix, S., Ryan, P., Davies, L., . . . Haberberger, R. (2015). Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in Molecular Neuroscience, 8(AUGUST), 1-13.
Scopus16 WoS17 Europe PMC92015 Barnawi, J., Hai, T., Jersmann, H., Pitson, S., Roscioli, E., Hodge, G., . . . Hodge, S. (2015). Potential link between the Sphingosine-1-Phosphate (S1P) system and defective alveolar macrophage phagocytic function in Chronic Obstructive Pulmonary Disease (COPD). PLoS One, 10(10), e0122771-1-e0122771-21.
Scopus47 WoS40 Europe PMC342015 Barry, C. M., Kestell, G., Gillan, M., Haberberger, R. V., & Gibbins, I. L. (2015). Sensory nerve fibers containing calcitonin gene-related peptide in gastrocnemius, latissimus dorsi and erector spinae muscles and thoracolumbar fascia in mice. Neuroscience, 291, 106-117.
Scopus37 WoS33 Europe PMC232013 Camprubí-Robles, M., Mair, N., Andratsch, M., Benetti, C., Beroukas, D., Rukwied, R., . . . Kress, M. (2013). Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. Journal of Neuroscience, 33(6), 2582-2592.
Scopus52 WoS52 Europe PMC382012 Sun, Y., Lim, Y., Li, F., Liu, S., Lu, J. J., Haberberger, R., . . . Zhou, X. F. (2012). ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS ONE, 7(4), 1-12.
Scopus127 WoS84 Europe PMC902011 Schirmer, S. U., Eckhardt, I., Lau, H., Klein, J., DeGraaf, Y. C., Lips, K. S., . . . Haberberger, R. V. (2011). The cholinergic system in rat testis is of non-neuronal origin. Reproduction, 142(1), 157-166.
Scopus33 WoS30 Europe PMC202011 Mair, N., Benetti, C., Andratsch, M., Leitner, M. G., Constantin, C. E., Camprubí-Robles, M., . . . Haberberger, R. V. (2011). Genetic evidence for involvement of neuronally expressed s1P<inf>1</inf> receptor in nociceptor sensitization and inflammatory pain. PLoS ONE, 6(2), 12 pages.
Scopus61 WoS57 Europe PMC442011 Vilimas, P. I., Yuan, S. Y., Haberberger, R. V., & Gibbins, I. L. (2011). Sensory innervation of the external genital tract of female Guinea pigs and mice. Journal of Sexual Medicine, 8(7), 1985-1995.
Scopus21 WoS20 Europe PMC132011 Park, K., Haberberger, R. V., Gordon, T. P., & Jackson, M. W. (2011). Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome. Arthritis and Rheumatism, 63(5), 1426-1434.
Scopus52 WoS46 Europe PMC262011 Cordts, F., Pitson, S., Tabeling, C., Gibbins, I., Moffat, D., Jersmann, H., . . . Haberberger, R. (2011). Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease. Life Sciences, 89(21-22), 806-811.
Scopus28 WoS25 Europe PMC232011 Tam Tam, S., Bastian, I., Zhou, X., Vander Hoek, M., Michael, M., Gibbins, I., & Haberberger, R. (2011). MicroRNA-143 expression in dorsal root ganglion neurons. Cell and Tissue Research, 346(2), 163-173.
Scopus36 WoS28 Europe PMC262011 Bastian, I., Tam Tam, S., Zhou, X., Kazenwadel, J., Van Der Hoek, M., Michael, M., . . . Haberberger, R. (2011). Differential expression of microRNA-1 in dorsal root ganglion neurons. Histochemistry and Cell Biology, 135(1), 37-45.
Scopus15 WoS13 Europe PMC142011 Clarke, J. N., Anderson, R. L., Haberberger, R. V., & Gibbins, I. L. (2011). Non-peptidergic small diameter primary afferents expressing VGluT2 project to lamina I of mouse spinal dorsal horn. Molecular Pain, 7, 17 pages.
Scopus10 WoS10 Europe PMC92010 Wilson, A. J., Carati, C. J., Gannon, B. J., Haberberger, R., & Chataway, T. K. (2010). Aquaporin-1 in blood vessels of rat circumventricular organs. Cell and Tissue Research, 340(1), 159-168.
Scopus23 WoS20 Europe PMC172009 Jositsch, G., Papadakis, T., Haberberger, R. V., Wolff, M., Wess, J., & Kummer, W. (2009). Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 379(4), 389-395.
Scopus128 WoS114 Europe PMC922009 Haberberger, R. V., Tabeling, C., Runciman, S., Gutbier, B., König, P., Andratsch, M., . . . Witzenrath, M. (2009). Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness. Journal of Allergy and Clinical Immunology, 124(5), 933-941.
Scopus32 WoS29 Europe PMC192009 Klein, M. K., Haberberger, R. V., Hartmann, P., Faulhammer, P., Lips, K. S., Krain, B., . . . König, P. (2009). Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. European Respiratory Journal, 33(5), 1113-1121.
Scopus51 WoS40 Europe PMC312008 Kindt, F., Wiegand, S., Niemeier, V., Kupfer, J., Löser, C., Nilles, M., . . . Haberberger, R. V. (2008). Reduced expression of nicotinic α subunits 3, 7, 9 and 10 in lesional and nonlesional atopic dermatitis skin but enhanced expression of α subunits 3 and 5 in mast cells. British Journal of Dermatology, 159(4), 847-857.
Scopus38 WoS29 Europe PMC192008 Ahlbrecht, K., Schmitz, J., Seay, U., Schwarz, C., Mittnacht-Kraus, R., Gaumann, A., . . . Voswinckel, R. (2008). Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development. American Journal of Respiratory Cell and Molecular Biology, 39(2), 163-170.
Scopus14 WoS12 Europe PMC102008 Kress, M., Karasek, J., Ferrer-Montiel, A. V., Scherbakov, N., & Haberberger, R. V. (2008). TRPC channels and diacylglycerol dependent calcium signaling in rat sensory neurons. Histochemistry and Cell Biology, 130(4), 655-667.
Scopus36 WoS34 Europe PMC272007 Kindt, F., Wiegand, S., Löser, C., Nilles, M., Niemeier, V., Hsu, S. Y. T., . . . Haberberger, R. V. (2007). Intermedin: A skin peptide that is downregulated in atopic dermatitis. Journal of Investigative Dermatology, 127(3), 605-613.
Scopus11 WoS12 Europe PMC72006 Haberberger, R., Schultheiss, G., & Diener, M. (2006). Epithelial muscarinic M<inf>1</inf> receptors contribute to carbachol-induced ion secretion in mouse colon. European Journal of Pharmacology, 530(3), 229-233.
Scopus33 WoS32 Europe PMC262006 Plato, M., Kummer, W., & Haberberger, R. V. (2006). Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung. Neuroscience Letters, 395(3), 215-219.
Scopus29 WoS26 Europe PMC202006 Kummer, W., Wiegand, S., Akinci, S., Wessler, I., Schinkel, A. H., Wess, J., . . . Lips, K. S. (2006). Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respiratory Research, 7(1), 12 pages.
Scopus72 WoS62 Europe PMC432006 Groth, M., Helbig, T., Grau, V., Kummer, W., & Haberberger, R. V. (2006). Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels. Respiratory Research, 7(1), 16 pages.
Scopus25 WoS20 Europe PMC172005 Chang, C. L., Roh, J., Park, J. I., Klein, C., Cushman, N., Haberberger, R. V., & Hsu, S. Y. T. (2005). Intermedin functions as a pituitary paracrine factor regulating prolactin release. Molecular Endocrinology, 19(11), 2824-2838.
Scopus38 WoS32 Europe PMC242005 Pfaff, M., Powaga, N., Akinci, S., Schütz, W., Banno, Y., Wiegand, S., . . . Haberberger, R. V. (2005). Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respiratory Research, 6(1), 14 pages.
Scopus37 WoS33 Europe PMC302005 Sequeira, I. M., Haberberger, R. V., & Kummer, W. (2005). Atrial and ventricular rat coronary arteries are differently supplied by noradrenergic, cholinergic and nitrergic, but not sensory nerve fibres. Annals of Anatomy, 187(4), 345-355.
Scopus17 WoS14 Europe PMC92005 Lang, P. M., Burgstahler, R., Haberberger, R. V., Sippel, W., & Grafe, P. (2005). A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves. NeuroReport, 16(5), 479-483.
Scopus28 WoS26 Europe PMC182004 Papadopolou, S., Hartmann, P., Lips, K. S., Kummer, W., & Haberberger, R. V. (2004). Nicotinic receptor mediated stimulation of NO-generation in neurons of rat thoracic dorsal root ganglia. Neuroscience Letters, 361(1-3), 32-35.
Scopus23 WoS22 Europe PMC162004 Henrich, M., Paddenberg, R., Haberberger, R. V., Scholz, A., Gruss, M., Hempelmann, G., & Kummer, W. (2004). Hypoxic increase in nitric oxide generation of rat sensory neurons requires activation of mitochondrial complex II and voltage-gated calcium channels. Neuroscience, 128(2), 337-345.
Scopus13 WoS11 Europe PMC112004 Haberberger, R. V., Bernardini, N., Kress, M., Hartmann, P., Lips, K. S., & Kummer, W. (2004). Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat. Autonomic Neuroscience: Basic and Clinical, 113(1-2), 32-42.
Scopus70 WoS71 Europe PMC502003 Pfeil, U., Lips, K. S., Eberling, L., Grau, V., Haberberger, R. V., & Kummer, W. (2003). Expression of the high-affinity choline transporter, CHT1, in the rat trachea. American Journal of Respiratory Cell and Molecular Biology, 28(4), 473-477.
Scopus45 WoS42 Europe PMC352003 Lips, K. S., Pfeil, U., Reiners, K., Rimasch, C., Kuchelmeister, K., Braun-Dullaeus, R. C., . . . Kummer, W. (2003). Expression of the High-affinity Choline Transporter CHT1 in Rat and Human Arteries. Journal of Histochemistry and Cytochemistry, 51(12), 1645-1654.
Scopus41 WoS38 Europe PMC332003 Hagner, S., Haberberger, R., Hay, D. L., Facer, P., Reiners, K., Voigt, K., & McGregor, G. P. (2003). Immunohistochemical detection of the calcitonin receptor-like receptor protein in the microvasculature of rat endothelium. European Journal of Pharmacology, 481(2-3), 147-151.
Scopus17 WoS15 Europe PMC132003 Dvorakova, M., Haberberger, R. V., Hagner, S., McGregor, G. P., Slavikova, J., & Kummer, W. (2003). Expression and distribution of the calcitonin receptor-like receptor in the developing rat heart. Anatomy and Embryology, 207(4-5), 307-315.
Scopus7 WoS7 Europe PMC72003 Henrich, M., Haberberger, R. V., Hempelmann, G., & Kummer, W. (2003). Quantitative immunohistochemical investigation of the intrinsic vasodilator innervation of the guinea pig lingual artery. Autonomic Neuroscience: Basic and Clinical, 103(1-2), 72-82.
Scopus7 WoS7 Europe PMC62003 Voswinckel, R., Ziegelhoeffer, T., Heil, M., Kostin, S., Breier, G., Mehling, T., . . . Seeger, W. (2003). Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circulation Research, 93(4), 372-379.
Scopus81 WoS73 Europe PMC492003 Struckmann, N., Schwering, S., Wiegand, S., Gschnell, A., Yamada, M., Kummer, W., . . . Haberberger, R. V. (2003). Role of Muscarinic Receptor Subtypes in the Constriction of Peripheral Airways: Studies on Receptor-Deficient Mice. Molecular Pharmacology, 64(6), 1444-1451.
Scopus99 WoS86 Europe PMC812003 Haberberger, R. V., Henrich, M., Lips, K. S., & Kummer, W. (2003). Nicotinic receptor alpha7-subunits are coupled to the stimulation of nitric oxide synthase in rat dorsal root ganglion neurons. Histochemistry and Cell Biology, 120(3), 173-181.
Scopus33 WoS31 Europe PMC222002 Hagner, S., Knauer, J., Haberberger, R., Göke, B., Voigt, K., & McGregor, G. P. (2002). Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells. Digestion, 66(4), 197-203.
Scopus24 WoS18 Europe PMC172002 Brüggmann, D., Lips, K. S., Pfeil, U., Haberberger, R. V., & Kummer, W. (2002). Multiple nicotinic acetylcholine receptora α-subunits are expressed in the arterial system of the rat. Histochemistry and Cell Biology, 118(6), 441-447.
Scopus40 WoS38 Europe PMC312002 Hagner, S., Haberberger, R. V., Overkamp, D., Hoffmann, R., Voigt, K. H., & McGregor, G. P. (2002). Expression and distribution of calcitonin receptor-like receptor in human hairy skin. Peptides, 23(1), 109-116.
Scopus40 WoS35 Europe PMC252002 Haberberger, R. V., Pfeil, U., Lips, K. S., & Kummer, W. (2002). Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. Journal of Investigative Dermatology, 119(4), 943-948.
Scopus42 WoS38 Europe PMC332002 Lips, K. S., Pfeil, U., Haberberger, R. V., & Kummer, W. (2002). Localisation of the high-affinity choline transporter-1 in the rat skeletal motor unit. Cell and Tissue Research, 307(3), 275-280.
Scopus37 WoS34 Europe PMC262001 Bernardini, N., Sauer, S. K., Haberberger, R., Fischer, M. J. M., & Reeh, P. W. (2001). Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin. Journal of Neuroscience, 21(9), 3295-3302.
Scopus84 WoS73 Europe PMC712001 Hagner, S., Haberberger, R., Kummer, W., Springer, J., Fischer, A., Böhm, S., . . . McGregor, G. P. (2001). Immunohistochemical detection of calcitonin gene-related peptide receptor (CGRPR)-1 in the endothelium of human coronary artery and bronchial blood vessels. Neuropeptides, 35(1), 58-64.
Scopus33 WoS28 Europe PMC202000 Haberberger, R. V., Bodenbenner, M., & Kummer, W. (2000). Expression of the cholinergic gene locus in pulmonary arterial endothelial cells. Histochemistry and Cell Biology, 113(5), 379-387.
Scopus44 WoS39 Europe PMC252000 Haberberger, R. V., & Bodenbenner, M. (2000). Immunohistochemical localization of muscarinic receptors (M2) in the rat skin. Cell and Tissue Research, 300(3), 389-396.
Scopus28 WoS23 Europe PMC212000 Haberberger, R., Scholz, A., Kummer, W., & Kress, M. (2000). M2-receptor subtype does not mediate muscarine-induced increases in [Ca<sup>2+</sup>](i) in nociceptive neurons of rat dorsal root ganglia. Journal of Neurophysiology, 84(4), 1934-1941.
Scopus26 WoS26 Europe PMC202000 Lührmann, A., Haberberger, R. V., Mörike, C., Steinhoff, G., Krug, N., Pabst, R., & Tschernig, T. (2000). The recruitment of immune cells into a grafted lung is not impaired in spite of incomplete reinnervation. Pneumologie, 54(12), 564-568.
1999 Kummer, W., Shigemoto, R., & Haberberger, R. (1999). Smooth muscle cells are the site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic nerve. Neuroscience Letters, 259(2), 119-122.
Scopus13 WoS12 Europe PMC111999 Haberberger, R., Henrich, M., Couraud, J. Y., & Kummer, W. (1999). Muscarinic M2-receptors in rat thoracic dorsal root ganglia. Neuroscience Letters, 266(3), 177-180.
Scopus19 WoS18 Europe PMC111998 Kummer, W., Fink, L., Dvorakova, M., Haberberger, R., & Bohle, R. M. (1998). Rat cardiac neurons express the non-coding R-exon (exon 1) of the cholinergic gene locus. NeuroReport, 9(10), 2209-2212.
Scopus19 WoS19 Europe PMC161997 Haberberger, R., Schemann, M., Sann, H., & Kummer, W. (1997). Innervation pattern of guinea pig pulmonary vasculature depends on vascular diameter. Journal of Applied Physiology, 82(2), 426-434.
Scopus41 WoS31 Europe PMC241997 Dötsch, J., Hänze, J., Dittrich, K., Demirakça, S., Haberberger, R., & Rascher, W. (1997). Stimulation of neuropeptide Y release in rat pheochromocytoma cells by nitric oxide. European Journal of Pharmacology, 331(2-3), 313-317.
Scopus10 WoS10 Europe PMC61996 Haberberger, R., & Kummer, W. (1996). β2-Adrenoreceptor immunoreactivity in cardiac ganglia of the guinea pig. Histochemical Journal, 28(11), 827-833.
Scopus8 WoS8 Europe PMC31995 Mcgregor, G. P., Hartel, R., Haberberger, R., Kummer, W., & Voigt, K. (1995). Preprotachykinin-A gene expression occurs transiently in the developing rat endocrine pancreas and can be regulated in RINm5F cells. Endocrinology, 136(6), 2538-2546.
Scopus26 WoS24 Europe PMC18 -
Conference Papers
Year Citation 2012 Camprubi-Robles, M., Mair, N., Andratsch, M., Benetti, C., Schmelz, M., Beroukas, D., . . . Kress, M. (2012). Sphingosine-1-phosphate evokes excitation of sensory neurons and nociception in mice and humans. In FEBS JOURNAL Vol. 279 (pp. 374). Seville, SPAIN: WILEY-BLACKWELL. 2012 Gutbier, B., Schoenrock, S. M., Haberberger, R., Hocke, A. C., Hippenstiel, S., Lueth, A., . . . Witzenrath, M. (2012). Sphingosine kinase-1 and sphingosine-1-phosphate promote the development of acute lung injury in pneumoccocal pneumonia. In EUROPEAN RESPIRATORY JOURNAL Vol. 40 (pp. 2 pages). EUROPEAN RESPIRATORY SOC JOURNALS LTD. 2008 Ahlbrecht, K., Seay, U., Schmitz, J., Haberberger, R. V., Kraus, R. M., Herold, S., . . . Voswinckel, R. (2008). Impact of the epithelial HIF 2 alpha system on lungdevelopment. In FASEB JOURNAL Vol. 22 (pp. 1 page). FEDERATION AMER SOC EXP BIOL. 2007 Lips, K. S., Lührmann, A., Tschernig, T., Stoeger, T., Alessandrini, F., Grau, V., . . . Kummer, W. (2007). Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. In Life Sciences Vol. 80 (pp. 2263-2269). Mainz, GERMANY: PERGAMON-ELSEVIER SCIENCE LTD.
Scopus60 WoS53 Europe PMC352006 Kummer, W., Wiegand, S., Akinci, S., Schinkel, A. H., Wess, J., Koepsell, H., . . . Lips, K. S. (2006). Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. In Journal of Molecular Neuroscience Vol. 30 (pp. 67-68). Alicante, SPAIN: HUMANA PRESS INC.
Scopus25 WoS20 Europe PMC182006 Spies, M., Lips, K. S., Kurzen, H., Kummer, W., & Haberberger, R. V. (2006). Nicotinic acetylcholine receptors containing subunits α3 and α5 in rat nociceptive dorsal root ganglion neurons. In Journal of Molecular Neuroscience Vol. 30 (pp. 55-56). Alicante, SPAIN: HUMANA PRESS INC.
Scopus17 WoS16 Europe PMC112006 Lips, K. S., König, P., Schätzle, K., Pfeil, U., Krasteva, G., Spies, M., . . . Kummer, W. (2006). Coexpression and spatial association of nicotinic acetylcholine receptor subunits α7 and α10 in rat sympathetic neurons. In Journal of Molecular Neuroscience Vol. 30 (pp. 15-16). Alicante, SPAIN: HUMANA PRESS INC.
Scopus25 WoS25 Europe PMC242003 Brüggmann, D., Lips, K. S., Pfeil, U., Haberberger, R. V., & Kummer, W. (2003). Rat arteries contain multiple nicotinic acetylcholine receptor α-subunits. In Life Sciences Vol. 72 (pp. 2095-2099). SAN FRANCISCO, CALIFORNIA: PERGAMON-ELSEVIER SCIENCE LTD.
Scopus33 WoS32 Europe PMC262003 Pfeil, U., Haberberger, R. V., Lips, K. S., Eberling, L., Grau, V., & Kummer, W. (2003). Expression of the high-affinity choline transporter CHT1 in epithelia. In Life Sciences Vol. 72 (pp. 2087-2090). SAN FRANCISCO, CALIFORNIA: PERGAMON-ELSEVIER SCIENCE LTD.
Scopus22 WoS17 Europe PMC152000 Kummer, W., Haberberger, R., & Fischer, A. (2000). Choline acetyltransferase in the airway wall. In European Respiratory Review Vol. 10 (pp. 257-259). 1999 Kummer, W., & Haberberger, R. (1999). Extrinsic and intrinsic cholinergic systems of the vascular wall. In European Journal of Morphology Vol. 37 (pp. 223-226). LNTEREN, NETHERLANDS: SWETS ZEITLINGER PUBLISHERS.
Scopus15 WoS15 Europe PMC11
Year | Funding Details |
2019 |
College Capacity Building Grant, Development of new teaching tools $11,800 |
2019 |
CNS Small Grant “Detection of miR-21 in exosomes released from 50B11 cells $4,000 |
2019 |
Breakthrough Foundation, RV Haberberger, N Spencer $6,000 |
2017 |
John Boyd Craig Research Award, Australian and New Zealand College of Anesthetists Exosomal miRNAs in cerebrospinal fluid as objective descriptors of pain states Paul Rolan, Porhan Kang, Rainer Viktor Haberberger, Dusan Matusica, Michael Michael $70,000 |
2016 |
Royal Adelaide Hospital Fund, Identification and altered regulatory miRNA expression associated with altered systemic cytokine expression in a clinical cohort of patients with recurrent depression at the RAH Catherine Toben, RV Haberberger, Bernard Baune $44,588 |
2016 |
Faculty & Flinders Medical Centre (FMC) Foundation Modulation of pain signalling via the cleavage of p75 neurotrophin receptor Dusan Matusica, RV Haberberger $17,000 |
2016 |
Faculty & Flinders Medical Centre (FMC) Foundation, Creation and characterization of nociceptive neuron subtypes: a first step towards a pain biosensor Rainer Viktor Haberberger, Dusan Matusica $18,000 |
2015 |
Flinders Medical Centre (FMC) Foundation, Equipment Grant, User-friendly Image Analysis System Software & Hardware Package (Imaris) for Flinders Microscopy Rainer Haberberger, Pam Sykes, Damian Hussey, Fiona Young, Dusan Matusica, Justine Smith, Shiwani Sharma $20,000 |
2015 |
Flinders Medical Centre (FMC) Foundation, Salary for an experienced technical assistant to provide histology-related services within Flinders Microscopy core facility, Rainer Haberberger, Dani Dixon, Damian Hussey, Justine Smith, Vladimir Zagorodnyuk $25,000 |
2015 |
Flinders Medical Centre (FMC) Foundation, Sphingosine kinase 2 signalling at the interface between primary nociceptor and microglia, Rainer Haberberger, Dusan Matusica $19,000 |
2015 |
Centre for Neuroscience, Small Grants, Sphingosine 1-phosphate signalling in microglia Haberberger $ 5,000 |
2014 |
Faculty of Medicine, Nursing and Health Sciences Small Grants, Equipment, Inverted fluorescence microscope with simple interface, and high quality digital image capture capability. Haberberger, Matusica, Franco, Hussey, Sharma, Meech, Muyderman $ 28,951.17 |
2014 |
Flinders Medical Centre Foundation Seeding Grant, The role of sphingosine kinase 2 in spinal cord glia as a key factor in the development of chronic pain Haberberger, Meech $ 16,300 |
2014 |
DVCR Near Miss Grant, Sphingosine kinase 2 and glial cells in spinal pain processing Haberberger, Muyderman, Meech $ 20,000 |
2013 |
Centre for Neuroscience, Small Grant, Epigenome modifying enzymes in dorsal root ganglia in response to inflammation Haberberger $ 4,900 |
2013 |
Faculty of Health Sciences Near miss grant Haberberger, Muyderman, Meech $ 15,000 |
2013 |
Faculty of Health Sciences Seeding Grant, The involvement of sphingosine kinase 2 and pain processing in the spinal cord dorsal horn Haberberger, Muyderman $ 15,000 |
2013 |
NHMRC Project grant APP1045514, Identification and therapeutic modulation of sphingolipids as novel lung macrophage-targeted treatments for COPD/emphysema S Hodge, RV Haberberger, P Reynolds, R Meech $ 670,475.81 |
2012 |
Flinders Medical Centre Foundation Competitive Grants, Seeding IL Gibbins, RV Haberberger Project: Optical measurement of peptide diffusion in mouse spinal cord $ 16,000 |
2012 |
Faculty of Health Sciences Competitive Grant, Infrastructure RV Haberberger, M Smith, D Keating, N Spencer Project: Purchase of a Nanodrop lite spectrophotometer plus pipettes $ 13,500 |
2011 |
Faculty of Health Sciences, FMC Foundation Top-Up Grant IL Gibbins, RV Haberberger $ 20,000 |
2011 |
Faculty of Health Sciences, FMC Foundation Top-Up Grant IL Gibbins, RV Haberberger $ 20,000 |
2011 |
NHMRC Equipment Grant Project: Upgrade of a StepOne cycler RV Haberberger, D Keating, M Smith, MZ Michael $ 21,900 |
2011 |
Defence Health Foundation Establishment Grant R.Haberberger, R. Meech Project: Epigenetic mechanisms in peripheral pain perception $ 34,657 |
2011 |
Australian Lung Foundation Ludwig Engel Grant-in-Aid for Physiological Research Project: Interaction of Endothelin and Sphingosine 1-phosphate in lung inflammation $ 3000 |
2010 |
IASP Collaborative Research Grant RV Haberberger, M. Kress Project: Pain susceptibility and peripheral pain signalling: role of epigenetic factors $ 15,000 |
2009-2011 |
NHMRC Project grant 535080 Sensory neuronal pathways from the lower genital tract of females IL. Gibbins, RV Haberberger, SJH Brookes, V. Zagorodnyuk $ 381,375 |
2009-2011 |
NHMRC Project grant 535055 Peripheral neuropathy and pain: The sphingosine kinase/sphingosine 1-phosphate system as a promising target RV Haberberger, M. Michael, IL. Gibbins $ 270,000 |
2008 |
Australian Brain Foundation RV Haberberger, IL. Gibbins, R. Flook $ 34,229 |
2008-2009 |
Faculty of Health Sciences RV Haberberger $ 5,000 |
2008-2009 |
FMC Foundation RV Haberberger, HPA Jersmann, S. Pitson $ 9,000 |
2008 |
NHMRC Equipment Grant RV Haberberger, M. Michael, D. Hussey, R. Rush, H. Muyderman $ 23,500 |
2008-2009 |
Faculty of Health Sciences RV Haberberger $ 5,000 |
2008-2009 |
FMC Foundation RV Haberberger, HPA Jersmann, S. Pitson $ 9,000 |
2008 |
NHMRC Equipment Grant RV Haberberger, M. Michael, D. Hussey, R. Rush, H. Muyderman $ 23,500 |
2007-2009 |
NHMRC Project grant 426750 Prof. I. Gibbins, R.V. Haberberger and Prof. S. Brookes, Anatomy/Physiology, Flinders University Adelaide $ 481,000 |
2006 |
Host laboratory for the Endeavour Research Fellowship F. Kindt, Germany $ 24,000 |
2006-2008 |
Else Kröner-Fresenius-Foundation Prof. A. Meinhardt, Anatomy Giessen, R.V. Haberberger 22,000 EUR, 1x BATIIa/2 |
2006 |
Flinders University, Faculty of Health Sciences Near-miss Grant R.V. Haberberger $ 6,000 |
2006 |
Collaborative Research Grants Program, International Society for the Study of Pain R. V. Haberberger, I.L. Gibbins, M. Kress 15,000 USD |
2006 |
Flinders Medical Centre Foundation Research Grant R. V. Haberberger $ 8,000 |
2005-2008 |
Mary Overton Neuroscience Fellowship ca. $140,000 p.a. |
2004-2007 |
Deutsche Forschungsgemeinschaft Grant R. V. Haberberger, V. Niemeier |
As chair of Anatomy, I aim to oversee Anatomy teaching across the University. My current teaching involves the development and coordination of the Allied Health course "Upper Limb, Head and Neuroscience" for 2nd year Physiotherapy students and the 2nd year Speech Pathology course "Anatomy and Physiology for Speech and Swallowing". In addition, I am responsible for the development and coordination of the "Cardiovascular" and "Respiratory" modules in the Foundation of Medicine part of the Bachelor of Medical Studies and Doctor of Medicine degree.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Co-Supervisor Characterization of Drugs Modulating the Aquaporin Channel Activity to Inhibit Angiogenesis and Metastasis Doctor of Philosophy Doctorate Full Time Ms Kim Kristin Wagner -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2011 - 2015 External Supervisor Genetic and Epigenetic Characterization of the Sphingosine-1-Phosphate Signalling System in Macrophages in Chronic Obstructive Pulmonary Disease Doctor of Philosophy Doctorate Full Time Mr Jameel Barnawi
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Board Memberships
Date Role Board name Institution name Country 2020 - 2021 Member Medical Program Board Flinders University Australia -
Committee Memberships
Date Role Committee Institution Country 2019 - 2020 Member Neuroscience Theme Lead and member of the Steering Committee Orama Institute for Mental Health, Wellbeing and Neuroscience Australia 2018 - 2021 Chair Flinders School of Anatomy Governance Committee Flinders University Australia 2016 - ongoing Member Steering Group Advanced Surgical Training Facility Australia 2016 - 2019 Member Scientific Program Committee Australian Pain Society Australia 2015 - 2018 Member Medical Course Management Committee Flinders University Australia 2015 - 2017 Member Flinders Medical Science and Technology Executive Flinders University Australia 2015 - 2017 Member Curriculum Working Group Flinders University Australia 2014 - ongoing Member International Committee, School of Medicine Flinders University Australia -
Memberships
Date Role Membership Country 2021 - ongoing Founder Founding member and Council member - Global Community of Anatomical Sciences Educators (GCASE) Australia 2019 - ongoing Member Inaugural Member, Faculty Australasian Pain School Australia 2016 - 2018 Chair Basic Pain Research SIG, Australian Pain Society Australia -
Editorial Boards
Date Role Editorial Board Name Institution Country 2016 - ongoing Board Member Cellular and Molecular Neurobiology Springer Australia -
Offices Held
Date Office Name Institution Country 2020 - 2021 Discipline Lead - Anatomy, Histology and Pathology Flinders University Australia 2018 - 2021 Topic coordinator years 1 & 2 Medical Course Flinders University Australia 2014 - 2021 Head of the Division of Anatomy & Histology Flinders University Australia 2014 - 2018 Deputy Director - Year 1 & 2 Medical Course Flinders University Australia 2014 - 2018 Theme coordinator Musculoskeletal System, 2nd year Medicine Flinders University Australia 2013 - 2016 Co-Organizer of the annual Pain Adelaide Meeting . Australia 2012 - 2019 Convener of the Centre for Neuroscience Flinders University Australia -
Review, Assessment, Editorial and Advice
Date Title Type Institution Country 2020 - 2020 Topic Editor, Brain Sciences Editorial Special edition “Function and Dysfunction of nociceptors - 2016 - ongoing Topic Editor, Peripheral Aspects of Pain Editorial Frontiers in Neurology - 2012 - ongoing External Reviewer Grant Assessment NHMRC Australia
Connect With Me
External Profiles