Qi Zhang

Dr Qi Zhang

EMBLAus(PLN) Group Leader, Cancer Epigenetics

South Australian Immunogenomics Cancer Institute

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr Qi Zhang leads the Epigenetics and Gene Regulation Lab, which studies the molecular mechanisms of epigenetic regulation. The lab primarily investigates the role of chromatin-modifying complexes in gene regulation and cancer biology, with the ultimate goal of translating fundamental lab-based discoveries into novel therapeutic strategies. To achieve this, the lab integrates methodologies from biochemistry, structural biology, cell biology, genomics, and bioinformatics.

  • Journals

    Year Citation
    2021 Guo, Y., Liu, Q., Mallette, E., Caba, C., Hou, F., Fux, J., . . . Zhang, W. (2021). Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. Journal of Biological Chemistry, 297(4), 1-13.
    DOI Scopus9 Europe PMC6
    2021 Zhang, Q., Agius, S. C., Flanigan, S. F., Uckelmann, M., Levina, V., Owen, B. M., & Davidovich, C. (2021). PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nature Communications, 12(1), 4592.
    DOI Scopus12 Europe PMC11
    2021 Davidovich, C., & Zhang, Q. (2021). Allosteric regulation of histone lysine methyltransferases: From context-specific regulation to selective drugs. Biochemical Society Transactions, 49(2), 591-607.
    DOI Scopus5 Europe PMC3
    2019 Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., . . . Tong, Y. (2019). Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. Proceedings of the National Academy of Sciences of the United States of America, 116(15), 7288-7297.
    DOI Scopus34 Europe PMC24
    2019 Zhang, Q., McKenzie, N. J., Warneford-Thomson, R., Gail, E. H., Flanigan, S. F., Owen, B. M., . . . Davidovich, C. (2019). RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nature Structural and Molecular Biology, 26(3), 237-247.
    DOI Scopus65 Europe PMC48
    2017 Gao, Y., Zhang, Q., Lang, Y., Liu, Y., Dong, X., Chen, Z., . . . Chen, Z. (2017). Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation. Journal of Molecular Cell Biology, 9(3), 220-230.
    DOI Scopus13 Europe PMC12
    2017 Zhang, Q., Wang, Z., Hou, F., Harding, R., Huang, X., Dong, A., . . . Tong, Y. (2017). The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear. Biochimica et Biophysica Acta - General Subjects, 1861(1), 3095-3105.
    DOI Scopus17 Europe PMC9
    2016 Zhang, Q., Harding, R., Hou, F., Dong, A., Walker, J. R., Bteich, J., & Tong, Y. (2016). Structural basis of the recruitment of ubiquitin-specific protease USP15 by spliceosome recycling factor SART3. Journal of Biological Chemistry, 291(33), 17283-17292.
    DOI Scopus21 Europe PMC16
    2016 Liu, Y., Tempel, W., Zhang, Q., Liang, X., Loppnau, P., Qin, S., & Min, J. (2016). Family-wide characterization of histone binding abilities of human CW domain-containing proteins. Journal of Biological Chemistry, 291(17), 9000-9013.
    DOI Scopus43 Europe PMC33
    2015 Deng, Z., Wang, Q., Liu, Z., Zhang, M., Machado, A. C. D., Chiu, T. P., . . . Chen, Z. (2015). Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nature Communications, 6(1), 7642.
    DOI Scopus86 Europe PMC69
    2015 Zhang, Q., Fan, L., Hou, F., Dong, A., Wang, Y. X., & Tong, Y. (2015). New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins. Scientific Reports, 5(1), 15660.
    DOI Scopus24 Europe PMC17
    2015 Zheng, J., Lang, Y., Zhang, Q., Cui, D., Sun, H., Jiang, L., . . . Chen, Z. (2015). Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Genes and Development, 29(14), 1524-1534.
    DOI Scopus61 Europe PMC45
    2014 Feng, C., Liu, Y., Wang, G., Deng, Z., Zhang, Q., Wu, W., . . . Chen, Z. (2014). Crystal structures of the human RNA demethylase alkbh5 reveal basis for substrate recognition. Journal of Biological Chemistry, 289(17), 11571-11583.
    DOI Scopus131 Europe PMC90
    2014 Deng, Z., Lehmann, K. C., Li, X., Feng, C., Wang, G., Zhang, Q., . . . Chen, Z. (2014). Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Research, 42(5), 3464-3477.
    DOI Scopus38 Europe PMC39
    2013 Zhang, X., Zhang, Q., & Wang, G. (2013). Crystallization and initial X-ray data of abscisic acid receptor PYL3 in the presence of (-)-ABA. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69(5), 540-543.
    DOI
    2013 Zhang, X., Jiang, L., Wang, G., Yu, L., Zhang, Q., Xin, Q., . . . Chen, Z. (2013). Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR. PLoS ONE, 8(7), e67477.
    DOI Scopus40 Europe PMC23
    2013 Zhang, Q., Qi, S., Xu, M., Yu, L., Tao, Y., Deng, Z., . . . Wong, J. (2013). Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. Cell Research, 23(2), 225-241.
    DOI Scopus54 Europe PMC40
    2012 Zhang, X., Zhang, Q., Xin, Q., Yu, L., Wang, Z., Wu, W., . . . Chen, Z. (2012). Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure, 20(5), 780-790.
    DOI Scopus66 Europe PMC40
    2010 Yu, L., Wang, Y., Huang, S., Wang, J., Deng, Z., Zhang, Q., . . . Chen, Z. (2010). Structural insights into a novel histone demethylase PHF8. Cell Research, 20(2), 166-173.
    DOI Scopus57 Europe PMC47

2024-2026 ARC ARC Discovery Project (Sole CI, $ $544k)

2023-2025 NHMRC Idea Grant (AI, $774k)

2023-2026 mRNA Victoria Activation Program Grant (CIA, $472k)

2022-2023 Monash BDI Career Continuity Grant (sole CI, $50k)

2022-2023 Monash BDI Advancing Women’s Success Grant (Sole CI, $10.5k)

2022-2024 NHMRC Idea Grant (AI, $849k)

2021-2022 NHMRC Equipment Grant (CI, $307k)

2021-2025 NHMRC Investigator Grant Emerging Leadership 1 (Sole CI, $595k,)

2020-2022 NHMRC Idea Grant (CIB, $714k)

2018-2020 ARC Discovery Early Career Researcher Award (Sole CI, $344k)

2018-2019 Monash Platform Access Grants (CIA, $5k)

  • Position: EMBLAus(PLN) Group Leader, Cancer Epigenetics
  • Phone: 83133755
  • Email: qi.zhang@adelaide.edu.au
  • Campus: West End Health Precinct
  • Building: AHMS - Adelaide Health and Medical Sciences, floor Ninth Floor
  • Room: 9065
  • Org Unit: South Australian Immunogenomics Cancer Institute

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