Dr Qi Zhang
Group Leader, SAiGENCI-EMBL Aust PLN
School of Pharmacy and Biomedical Science
College of Health
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Qi Zhang leads the Epigenetics and Gene Regulation Lab, which studies the molecular mechanisms of epigenetic regulation. The lab primarily investigates the role of chromatin-modifying complexes in gene regulation and cancer biology, with the ultimate goal of translating fundamental lab-based discoveries into novel therapeutic strategies. To achieve this, the lab integrates methodologies from biochemistry, structural biology, cell biology, genomics, and bioinformatics.
| Year | Citation |
|---|---|
| 2025 | Fan, P., Shang, X. -Y., Song, A., Chen, S., Mao, R. -Y., Ma, J., . . . Chen, F. X. (2025). Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition.. Nat Chem Biol, 21(6), 959-970. Scopus7 WoS5 Europe PMC6 |
| 2025 | Uckelmann, M., Levina, V., Taveneau, C., Ng, X. H., Pandey, V., Martinez, J., . . . Davidovich, C. (2025). Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates. Nature Structural and Molecular Biology, 32(3), 520-530. Scopus6 WoS7 Europe PMC10 |
| 2025 | Deevy, O., Li, J., Monger, C., Matrà, F., Tuck, E., Davies, M., . . . Bracken, A. P. (2025). Dominant-negative effects of Weaver syndrome-associated EZH2 variants. Genes and Development, 39(21-22), 1355-1376. Scopus1 Europe PMC1 |
| 2025 | Mucha, M., Lai, Z., McKenzie, N. J., Matrà, F., Boudes, M., Flanigan, S. F., . . . Bracken, A. P. (2025). Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2. EMBO Journal, 44(23), 6979-7020. |
| 2024 | Gail, E. H., Healy, E., Flanigan, S. F., Jones, N., Ng, X. H., Uckelmann, M., . . . Davidovich, C. (2024). Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2. Nature Genetics, 56(6), 1193-1202. Scopus12 WoS12 Europe PMC15 |
| 2024 | Healy, E., Zhang, Q., Gail, E. H., Agius, S. C., Sun, G., Bullen, M., . . . Davidovich, C. (2024). The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion. Cell Reports, 43(3), 113858-1-113858-12. Scopus14 WoS14 Europe PMC18 |
| 2021 | Zhang, Q., & Davidovich, C. (2021). Crystal structure of EED in complex with PALI1-K1219me3 peptide. |
| 2021 | Guo, Y., Liu, Q., Mallette, E., Caba, C., Hou, F., Fux, J., . . . Zhang, W. (2021). Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. Journal of Biological Chemistry, 297(4), 1-13. Scopus15 WoS14 Europe PMC12 |
| 2021 | Zhang, Q., Agius, S. C., Flanigan, S. F., Uckelmann, M., Levina, V., Owen, B. M., & Davidovich, C. (2021). PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nature Communications, 12(1), 4592. Scopus28 WoS19 Europe PMC40 |
| 2021 | Davidovich, C., & Zhang, Q. (2021). Allosteric regulation of histone lysine methyltransferases: From context-specific regulation to selective drugs. Biochemical Society Transactions, 49(2), 591-607. Scopus6 WoS5 Europe PMC5 |
| 2019 | Paudel, P., Zhang, Q., Leung, C., Greenberg, H. C., Guo, Y., Chern, Y. H., . . . Tong, Y. (2019). Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. Proceedings of the National Academy of Sciences of the United States of America, 116(15), 7288-7297. Scopus47 WoS47 Europe PMC46 |
| 2019 | Zhang, Q., McKenzie, N. J., Warneford-Thomson, R., Gail, E. H., Flanigan, S. F., Owen, B. M., . . . Davidovich, C. (2019). RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nature Structural and Molecular Biology, 26(3), 237-247. Scopus85 WoS82 Europe PMC88 |
| 2017 | Gao, Y., Zhang, Q., Lang, Y., Liu, Y., Dong, X., Chen, Z., . . . Chen, Z. (2017). Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation. Journal of Molecular Cell Biology, 9(3), 220-230. Scopus15 WoS15 Europe PMC14 |
| 2017 | Zhang, Q., Wang, Z., Hou, F., Harding, R., Huang, X., Dong, A., . . . Tong, Y. (2017). The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear. Biochimica Et Biophysica Acta General Subjects, 1861(1), 3095-3105. Scopus26 WoS25 Europe PMC25 |
| 2016 | Zhang, Q., Harding, R., Hou, F., Dong, A., Walker, J. R., Bteich, J., & Tong, Y. (2016). Structural basis of the recruitment of ubiquitin-specific protease USP15 by spliceosome recycling factor SART3. Journal of Biological Chemistry, 291(33), 17283-17292. Scopus24 WoS23 Europe PMC23 |
| 2016 | Liu, Y., Tempel, W., Zhang, Q., Liang, X., Loppnau, P., Qin, S., & Min, J. (2016). Family-wide characterization of histone binding abilities of human CW domain-containing proteins. Journal of Biological Chemistry, 291(17), 9000-9013. Scopus47 WoS47 Europe PMC48 |
| 2016 | Dong, A., Zhang, Q., Walker, J. R., Bountra, C., Arrowsmith, C. H., Edwards, A. M., & Tong, Y. (2016). Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain. |
| 2016 | Walker, J. R., Zhang, Q., Dong, A., Wernimont, A., Li, Y., He, H., . . . Tong, Y. (2016). CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN. |
| 2016 | DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C. H., Edwards, A. M., & TONG, Y. (2016). Crystal structure of the HAT domain of sart3. |
| 2015 | Walker, J. R., Dong, A., Zhang, Q., Ong, M., Duan, S., Li, Y., . . . Tong, Y. (2015). Tandem Tudor and PHD domains of UHRF2. |
| 2015 | DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C. H., Edwards, A. M., & TONG, Y. (2015). Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA. |
| 2015 | Deng, Z., Wang, Q., Liu, Z., Zhang, M., Machado, A. C. D., Chiu, T. P., . . . Chen, Z. (2015). Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nature Communications, 6(1), 12 pages. Scopus103 WoS104 Europe PMC87 |
| 2015 | Zhang, Q., Fan, L., Hou, F., Dong, A., Wang, Y. X., & Tong, Y. (2015). New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins. Scientific Reports, 5(1), 13 pages. Scopus29 WoS24 Europe PMC29 |
| 2015 | Zheng, J., Lang, Y., Zhang, Q., Cui, D., Sun, H., Jiang, L., . . . Chen, Z. (2015). Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Genes and Development, 29(14), 1524-1534. Scopus73 WoS74 Europe PMC70 |
| 2014 | Feng, C., Liu, Y., Wang, G., Deng, Z., Zhang, Q., Wu, W., . . . Chen, Z. (2014). Crystal structures of the human RNA demethylase alkbh5 reveal basis for substrate recognition. Journal of Biological Chemistry, 289(17), 11571-11583. Scopus170 WoS168 Europe PMC156 |
| 2014 | Deng, Z., Lehmann, K. C., Li, X., Feng, C., Wang, G., Zhang, Q., . . . Chen, Z. (2014). Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Research, 42(5), 3464-3477. Scopus49 WoS48 Europe PMC51 |
| 2014 | Dong, A., Zhang, Q., Li, Y., Walker, J. R., Guan, X., Bountra, C., . . . Tong, Y. (2014). Crystal Structure of a Functionally Uncharacterized Domain of E3 Ubiquitin Ligase SHPRH. |
| 2014 | Walker, J. R., Dong, A., Zhang, Q., Huang, X., Li, Y., Bountra, C., . . . Tong, Y. (2014). Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide. |
| 2013 | Zhang, Q., & Chen, Z. (2013). Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic. |
| 2013 | Zhang, Q., & Chen, Z. (2013). Native structure of LSD2/AOF1/KDM1b in spacegroup of I222 at 2.9A. |
| 2013 | Zhang, Q., & Chen, Z. (2013). Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A. |
| 2013 | Zhang, X., Zhang, Q., & Wang, G. (2013). Crystallization and initial X-ray data of abscisic acid receptor PYL3 in the presence of (-)-ABA. Acta Crystallographica Section F Structural Biology and Crystallization Communications, 69(5), 540-543. |
| 2013 | Zhang, X., Jiang, L., Wang, G., Yu, L., Zhang, Q., Xin, Q., . . . Chen, Z. (2013). Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR. Plos One, 8(7), 10 pages. Scopus42 WoS35 Europe PMC31 |
| 2013 | Zhang, Q., Qi, S., Xu, M., Yu, L., Tao, Y., Deng, Z., . . . Wong, J. (2013). Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b. Cell Research, 23(2), 225-241. Scopus60 WoS59 Europe PMC53 |
| 2012 | Zhang, X., Zhang, Q., Xin, Q., Yu, L., Wang, Z., Wu, W., . . . Chen, Z. (2012). Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure, 20(5), 780-790. Scopus72 WoS63 Europe PMC54 |
| 2012 | Zhang, X., Zhang, Q., Wang, G., & Chen, Z. (2012). Complex structure of abscisic acid receptor PYL3-(+)-ABA-HAB1 in the presence of Mn2+. |
| 2012 | Zhang, X., Zhang, Q., & Chen, Z. (2012). Complex Structure of Abscisic Acid Receptor PYL3 with (+)-ABA in Spacegroup of I 212121 at 2.70A. |
| 2010 | Yu, L., Wang, Y., Huang, S., Wang, J., Deng, Z., Zhang, Q., . . . Chen, Z. (2010). Structural insights into a novel histone demethylase PHF8. Cell Research, 20(2), 166-173. Scopus66 WoS64 Europe PMC61 |
| - | Zhang, X., Zhang, Q., Wang, G., & Chen, Z. (2011). X-ray crystal structure of the Py13 -pyrabactin complex. |
| - | Dong, A., Zhang, Q., Walker, J. R., Bountra, C., Arrowsmith, C. H., Edwards, A. M., & Tong, Y. (2018). Crystal structure of the catalytic domain of human USP9X. |
| - | DONG, A., ZHANG, Q., TEMPEL, W., Bountra, C., Arrowsmith, C. H., Edwards, A. M., & TONG, Y. (2015). Crystal structure of the ROQ domain of human Roquin-2. |
| - | Zhang, X., Zhang, Q., & Chen, Z. (2013). Crystal structure of native abscisic acid receptor PYL5 at 2.65 Angstrom. |
| - | Zhang, Q., & Davidovich, C. (2021). Crystal structure of EED in complex with PALI1-K1241me3 peptide. |
| - | Zhang, X., Zhang, Q., & Chen, Z. (2011). Crystal structure of native abscisic acid receptor PYL9 with ABA. |
| - | Dong, A., Zhang, Q., Walker, J. R., Bountra, C., Arrowsmith, C. H., Edwards, A. M., & Tong, Y. (2016). Crystal structure of siah2 SBD domain. |
| - | Dong, A., Zhang, Q., Li, Y., Tempel, W., Bountra, C., Arrowsmith, C. H., . . . Tong, Y. (2015). Crystal structure of the ROQ domain of human Roquin-1. |
| Year | Citation |
|---|---|
| 2023 | Barszczyk, A., Bandura, J., Zhang, Q., Wang, H., Deurloo, M., Ahmed, Y., . . . Feng, Z. -P. (2023). Caltubin regulates microtubule stability via Ca<sup>2+</sup>-dependent mechanisms favouring neurite regrowth. DOI |
| 2023 | Healy, E., Zhang, Q., Gail, E., Agius, S., Sun, G., Bullen, M., . . . Davidovich, C. (2023). The apparent loss of PRC2 chromatin occupancy as an artefact of RNA depletion. DOI Europe PMC2 |
| 2023 | Uckelmann, M., Levina, V., Taveneau, C., Ng, X. H., Pandey, V., Martinez, J., . . . Davidovich, C. (2023). Dynamic PRC1-CBX8 stabilizes a porous structure of chromatin condensates. DOI |
| 2023 | Deevy, O., Monger, C., Matrà, F., Tuck, E., Conway, E., Badonyi, M., . . . Bracken, A. (2023). Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants. DOI Europe PMC2 |
2025-2030 CSL Centenary Fellowship (sole CI, $1.25m)
2024-2026 ARC ARC Discovery Project (Sole CI, $544k)
2023-2025 NHMRC Idea Grant (AI, $774k)
2023-2026 mRNA Victoria Activation Program Grant (CIA, $472k)
2022-2023 Monash BDI Career Continuity Grant (sole CI, $50k)
2022-2023 Monash BDI Advancing Women’s Success Grant (Sole CI, $10.5k)
2022-2024 NHMRC Idea Grant (AI, $849k)
2021-2022 NHMRC Equipment Grant (CI, $307k)
2021-2025 NHMRC Investigator Grant Emerging Leadership 1 (Sole CI, $595k,)
2020-2022 NHMRC Idea Grant (CIB, $714k)
2018-2020 ARC Discovery Early Career Researcher Award (Sole CI, $344k)
2018-2019 Monash Platform Access Grants (CIA, $5k)
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2025 | Principal Supervisor | Cancer Epigenetics | Doctor of Philosophy | Doctorate | Full Time | Ms Suchandana Deka |
| 2025 | Principal Supervisor | Investigating the role of epigenetic regulation in neural development and disease | Doctor of Philosophy | Doctorate | Full Time | Miss Ruoxuan Jia |
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