Philip Gregory
Adelaide Medical School
Faculty of Health and Medical Sciences
Asoociate Professor Philip Gregory
Head, Gene Regulation in Cancer Laboratory
Centre for Cancer Biology: An Alliance between University of South Australia and SA Pathology.
A/Prof Philip Gregory is researching the new and exciting area of ‘microRNAs’. These are tiny particles of genetic material that exist inside cells and regulate how our genes are switched on and off. MicroRNAs were only discovered relatively recently and their role in the development of breast cancer is just beginning to be explored.
A/Prof Gregory is interested in how microRNAs influence breast and prostate cancer cells to spread to other parts of the body – a process known as metastasis. Metastatic (or secondary) breast cancer is currently very difficult to treat effectively, so understanding how metastasis occurs could lead to the development of more effective treatments and improved prevention strategies.
Epithelial cell plasticity (or epithelial-mesenchymal transition, EMT) plays a major role in the driving cancer cell invasion and their metastasis to other organs. My lab is examining how EMT and cancer metastasis are regulated by microRNAs. In particular, our research focusses on how microRNAs alter the cancer cell transcriptome using in vitro and in vivo cancer models coupled with next generation sequencing.
Gene Regulation in Cancer Laboratory
The Gene Regulation in Cancer Laboratory within the Centre for Cancer Biology investigates the molecular mechanisms controlling tumour cell plasticity in breast and prostate cancer, with a specific focus on the role of microRNAs and alternative splicing in this process. A/Prof. Gregory's groundbreaking research identified the miR-200 family as central regulators of epithelial-mesenchymal transition (Nature Cell Biology, >3000 citations). His lab uses the latest advances in transcriptomics coupled with in vitro and in vivo cancer models to investigate how cancer cells progress towards a metastatic state.
Project 1
Title: Function of alternative splice variants in cancer cell plasticity
Description: Using CRISPR gene editing, this project will uncover the function of alternatively spliced variants that are strongly induced in invasive cancer cells but whose function has not yet been investigated.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
Project 2
Title: How microRNAs regulate breast cancer metastasis
Description: This project will determine the target genes of miRNAs that function in breast cancer progression and metastasis using cell culture and animal models.
Projects available for: Honours and HDR
Location: Centre for Cancer Biology
Research Project Start: Semester 1 and 2
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Appointments
Date Position Institution name 2015 - ongoing Laboratory Head Centre for Cancer Biology -
Education
Date Institution name Country Title 2005 Flinders University Australia Doctor of Philosophy 1997 Flinders University Australia Bachelor of Biotechnology (Honours) -
Research Interests
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Journals
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Book Chapters
Year Citation 2013 Lecce, L., Lam, Y. T., & Ng, M. K. C. (2013). Role of sex steroids in angiogenesis. In Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 159-180). Springer New York.
DOI Scopus12013 Dunn, L. L., Chan, K. H., Ng, M. K. C., & Stocker, R. (2013). Vascular complications in diabetes. In Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases (pp. 313-337). Springer Vienna.
DOI2005 Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. In H. Sies, & L. Packer (Eds.), PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS (Vol. 400, pp. 22-46). ELSEVIER ACADEMIC PRESS INC.
DOI WoS17 -
Conference Papers
Year Citation 2018 Gomez, G. A., Woodcock, J. M., Tergaonkar, V., & Gregory, P. A. (2018). Meeting Report: The 8th Barossa Meeting - Cell Signaling in Cancer Medicine in the Barossa Valley, Australia. In Cell Death and Disease Vol. 9 (pp. 3 pages). England: SPRINGERNATURE.
DOI2013 Hirsh, S. L., Bilek, M. M. M., Bax, D. V., Kondyurin, A., Kosobrodova, E., Tsoutas, K., . . . Weiss, A. S. (2013). Ion implanted, radical-rich surfaces for the rapid covalent immobilization of active biomolecules. In AIP Conference Proceedings Vol. 1525 (pp. 364-369). AIP.
DOI Scopus42012 Javadzadegan, A., Yong, A. S. C., Chang, M., Mansour, N., Ng, M. K. C., Behnia, M., & Kritharides, L. (2012). Comparison of four different fluid structure interaction models in a human coronary artery. In Proceedings of the 18th Australasian Fluid Mechanics Conference, AFMC 2012. 2005 Mackenzie, P. I., Gregory, P. A., Lewinsky, R. H., Yasmin, S. N., Height, T., McKinnon, R. A., & Gardner-Stephen, D. A. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases. In Toxicology and Applied Pharmacology Vol. 207 (pp. 77-83). United States: Elsevier BV.
DOI Scopus39 Europe PMC202004 Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., . . . Ritter, J. K. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. In Drug Metabolism and Disposition Vol. 32 (pp. 281-290). United States: AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS.
DOI Scopus223 WoS175 Europe PMC124 -
Conference Items
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Preprint
Year Citation 2022 Neumann, D., Pillman, K., Dredge, K., Bert, A., Bracken, C., Hollier, B., . . . Gregory, P. (2022). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking.
DOI
1. GREGORY PA (CIA) Discovery of optimal targets to better diagnose and treat metastatic cancer. Beat Cancer Principal Research Fellowship. Funding for 2019-2021.
2. GREGORY PA (CIA), Goodall GJ, Hollier BG Characterising an RNA splicing pathway driving prostate cancer metastasis and therapy resistance. NHMRC Project Grant APP1164669. Funding for 2019-2021.
3. GREGORY PA (CIA), Anderson RL, Goodall GJ miR-342 – a novel suppressor of a pro-metastatic gene network in triple-negative breast cancer. National Breast Cancer Foundation IIRS-18-147. Funding for 2018-2020.
4. GREGORY PA (CIA), Goodall GJ Characterising novel alternative splicing networks that promote tumour cell plasticity. NHMRC Project Grant APP1128479. Funding for 2017-2019.
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2014 - 2016 Co-Supervisor The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Rajdeep Das 2013 - 2014 Co-Supervisor Novel Fibroblast Growth Factor Receptor Signalling Pathways Regulating Neuronal Differentiation Master of Philosophy (Medical Science) Master Full Time Dr Yang Kong 2012 - 2017 Co-Supervisor A Role for Bivalent Genes in Epithelial to Mesenchymal Transition Doctor of Philosophy Doctorate Part Time Mr Francisco Sadras 2012 - 2024 Co-Supervisor Regulation of Breast Cancer Progression and Metastasis by MicroRNA-342-3p Doctor of Philosophy Doctorate Part Time Dr Victoria Kiriaki Arnet 2010 - 2012 Co-Supervisor The miR 200 Family is Controlled by Epigenetic based Mechanisms and Mediates Transition Between Non Stem and Stem like Cell Phenotypes Doctor of Philosophy Doctorate Full Time Mr Yat Yuen Lim 2008 - 2013 Co-Supervisor Regulation of the microRNA-200 family during epithelial to mesenchymal transition Doctor of Philosophy Doctorate Full Time Miss Natasha Kolesnikoff
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