Philip Gregory

Research Interests

Biochemistry & Molecular Biology Cancer Cell Biology Genomics Cancer Biology and Clinical Oncology

APrf Philip Gregory

Associate Research Professor

Centre for Cancer Biology

College of Health

Available For Media Comment.

A/Prof Gregory leads the Gene Regulation in Cancer Laboratory within the Centre for Cancer Biology. His research focusses on cancer cell plasticity (often called EMT) and metastasis in the context of breast and prostate cancer, and how these processes are regulated by dynamic changes in the transcriptome. He has specific expertise in the areas of microRNAs, RNA binding proteins, and alternative splicing. As an NHMRC Peter Doherty Training fellowship he made seminal discoveries about the functions of microRNAs in epithelial-mesenchymal transition (EMT), a hallmark feature of cancer progression (Nature Cell Biol 2008, >4000 cites, Cancer Research 2008, >1000 cites). As a National Breast Cancer Foundation Early Career fellow, he uncovered key mechanisms through which microRNAs control EMT and tumour metastasis (published in Mol Biol Cell 2011, >500 cites and Oncogene 2014). As a Cancer Council Mid-Career fellow, he started an independent lab investigating gene regulatory mechanisms controlling breast and prostate tumour progression, with a particular focus on alternative splicing (Cell 2015, >1500 cites and EMBO J 2018). A/Prof Gregory held a Beat Cancer Principal Research Fellow from 2019-2021 and is Associate Editor of the journal Oncogenesis.

Tumour metastasis is the major cause of cancer related death in solid tumours such as the breast and prostate. My laboratory conducts research into understanding how tumour cells gain aggressive properties and spread throughout the body. We focus on identifying the importance of the molecular changes that occur as cells transition to aggressive forms, specifically on RNA changes involving microRNAs and alternative splicing (including circular RNAs).

Date Position Institution name
2015 - ongoing Laboratory Head Centre for Cancer Biology

Date Institution name Country Title
2005 Flinders University Australia Doctor of Philosophy
1997 Flinders University Australia Bachelor of Biotechnology (Honours)

Year Citation
2025 Liu, D., Wang, X., Zhang, Y., Zuo, S., Chereda, B., Gregory, P. A., . . . Goodall, G. J. (2025). A Dual-Selection System for Enhanced Efficiency and Fidelity of Circular RNA Overexpression. Journal of Molecular Biology, 437(10), 169064-1-169064-10.
DOI Scopus1 WoS1 Europe PMC1
2025 Orang, A., Warnock, N. I., Migault, M., Dredge, B. K., Bert, A. G., Bracken, J. M., . . . Bracken, C. P. (2025). Chasing non-existent "microRNAs" in cancer. Oncogenesis, 14(1, article no. 10), 10-1-10-9.
DOI Scopus4 WoS4 Europe PMC4
2025 Toubia, J., Kusay, Y., Maqsood, M., Warnock, N. I., Lawrence, D. M., Bracken, C. P., . . . Schreiber, A. W. (2025). TRanscriptome ANalysis of StratifiEd CohorTs (TRANSECT) enables automated assessment of global gene regulation linked to disparate expression in user defined genes and gene sets. NAR Genomics and Bioinformatics, 7(2), lqaf041-1-lqaf041-13.
DOI
2025 Kachooei, S. A., Bracken, J. M., Pillman, K. A., Gregory, P. A., & Bracken, C. P. (2025). Half of annotated human microRNAs are expressed at levels of questionable biological significance. Iscience, 28(9), 14 pages.
DOI
2025 Lynam, L. -R., Rockstroh, A., Lehman, M., Tang, Y. H., Nguyen, M. L. N., Gregory, P. A., . . . Hollier, B. G. (2025). Bulk RNA sequencing dataset of Claudin-low breast cancer cell lines with Neuropilin-1 knockdown.. Scientific data.
DOI
2025 Hindes, M. T., McElligott, A. M., Best, O. G., Ward, M. P., Selemidis, S., Miles, M. A., . . . Brooks, D. A. (2025). Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer. Cancer Letters, 611(217441), 217441-1-217441-18.
DOI Scopus7 WoS7 Europe PMC8
2024 Nturubika, B. D. D., Logan, J., Johnson, I. R. D., Moore, C., Li, K. L., Tang, J., . . . Brooks, D. A. (2024). Components of the endosome-lysosome vesicular machinery as drivers of the metastatic cascade in prostate cancer. Cancers, 17(1), 1, article no. 43-31.
DOI Scopus2 WoS2 Europe PMC1
2024 Bracken, C. P., Goodall, G. J., & Gregory, P. A. (2024). RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer (vol 102, pg 4, 2024). SEMINARS IN CANCER BIOLOGY, 106, 13-14.
DOI WoS1
2024 Liu, D., Dredge, B. K., Bert, A. G., Pillman, K. A., Toubia, J., Guo, W., . . . Goodall, G. J. (2024). ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic Acids Research, 52(3), 1387-1403.
DOI Scopus19 WoS17 Europe PMC13
2024 Neumann, D. P., Phillips, C. A., Lumb, R., Palethorpe, H. M., Ramani, Y., Hollier, B. G., . . . Gregory, P. A. (2024). Quaking isoforms cooperate to promote the mesenchymal phenotype. Molecular biology of the cell, 35(2), ar17-1-ar17-12.
DOI Scopus3 WoS2 Europe PMC2
2024 Neumann, D. P., Pillman, K. A., Dredge, B. K., Bert, A. G., Phillips, C. A., Lumb, R., . . . Gregory, P. A. (2024). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. RNA Biology, 21(1), 1-11.
DOI Scopus8 WoS7 Europe PMC24
2024 Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 42(2), 49-61.
DOI Scopus3 WoS3 Europe PMC1
2024 Bracken, C. P., Goodall, G. J., & Gregory, P. A. (2024). RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer. Seminars in Cancer Biology, 102-103, 4-16.
DOI Scopus20 WoS21 Europe PMC19
2024 Nturubika, B. D., Guardia, C. M., Gershlick, D. C., Logan, J. M., Martini, C., Heatlie, J. K., . . . Johnson, I. R. D. (2024). Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression. British Journal of Cancer, 131(8), 1263-1278.
DOI Scopus2 WoS3 Europe PMC2
2023 Sapkota, S., Pillman, K. A., Dredge, B. K., Liu, D., Bracken, J. M., Kachooei, S. A., . . . Goodall, G. J. (2023). On the rules of engagement for microRNAs targeting protein coding regions. Nucleic Acids Research, 51(18), 9938-9951.
DOI Scopus12 WoS12 Europe PMC12
2023 Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17.
DOI Scopus3 WoS3 Europe PMC8
2023 King, J., Evans, C., Kadolsky, U., Norret, M., Iqbal, M., Mercé, C., . . . Smith, N. (2023). Metastable Intermediates Identified in Epithelial to Mesenchymal Transition are Regulated by G-Quadruplex DNA Structures.
DOI Europe PMC2
2022 Tang, Y. H., Rockstroh, A., Sokolowski, K. A., Lynam, L. R., Lehman, M., Thompson, E. W., . . . Hollier, B. G. (2022). Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation. Breast Cancer Research, 24(1), 17 pages.
DOI Scopus23 WoS23 Europe PMC21
2022 Neumann, D. P., Goodall, G. J., & Gregory, P. A. (2022). The Quaking RNA-binding proteins as regulators of cell differentiation. Wiley interdisciplinary reviews. RNA, 13(6), e1724-1-e1724-19.
DOI Scopus31 WoS32 Europe PMC31
2022 Chi, L. H., Cross, R. S. N., Redvers, R. P., Davis, M., Hediyeh-Zadeh, S., Mathivanan, S., . . . Anderson, R. L. (2022). MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms. Oncogenesis, 11(1, article no. 38), 1-12.
DOI Scopus30 WoS29 Europe PMC23
2021 Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., . . . Selth, L. A. (2021). Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer. Cell Reports, 34(1), 1-17.
DOI Scopus41 WoS41 Europe PMC42
2021 Chan, K. M., Gleadle, J. M., Gregory, P. A., Phillips, C. A., Safizadeh Shirazi, H., Whiteley, A., . . . Macgregor, M. (2021). Selective microfluidic capture and detection of prostate cancer cells from urine without digital rectal examination. Cancers, 13(21, article no. 5544), 5544-1-5544-17.
DOI Scopus10 WoS9 Europe PMC8
2020 Saunders, K., Bert, A. G., Dredge, B. K., Toubia, J., Gregory, P. A., Pillman, K. A., . . . Bracken, C. P. (2020). Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing. Scientific Reports, 10(1), 1-9.
DOI Scopus13 WoS11 Europe PMC9
2019 Pillman, K. A., Scheer, K. G., Hackett-Jones, E., Saunders, K., Bert, A. G., Toubia, J., . . . Bracken, C. P. (2019). Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA). Nucleic Acids Research, 47(16), 14 pages.
DOI Scopus8 WoS7 Europe PMC9
2019 Gregory, P. A. (2019). The miR-200-Quaking axis functions in tumour angiogenesis. Oncogene, 38(41), 6767-6769.
DOI Scopus4 WoS4 Europe PMC3
2019 Pinweha, P., Phillips, C. A., Gregory, P. A., Li, X., Chuayboonya, P., Mongkolsiri, P., . . . Jitrapakdee, S. (2019). MicroRNA-143-3p targets pyruvate carboxylase expression and controls proliferation and migration of MDA-MB-231 cells. Archives of Biochemistry and Biophysics, 677(108169), 10 pages.
DOI Scopus15 WoS17 Europe PMC11
2018 Cursons, J., Pillman, K. A., Scheer, K. G., Gregory, P. A., Foroutan, M., Hediyeh-Zadeh, S., . . . Davis, M. J. (2018). Combinatorial targeting by MicroRNAs co-ordinates post-transcriptional control of EMT. Cell Systems, 7(1), 77-91.
DOI Scopus74 WoS70 Europe PMC75
2018 Neumann, D. P., Goodall, G. J., & Gregory, P. A. (2018). Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity. Seminars in Cell and Developmental Biology, 75, 50-60.
DOI Scopus23 WoS20 Europe PMC20
2018 Gomez, G. A., Woodcock, J. M., Tergaonkar, V., & Gregory, P. A. (2018). Meeting report: The 8th Barossa Meeting - Cell signaling in cancer medicine in the Barossa Valley, Australia. Cell death and disease, 9(3, article no. 284), 1-3.
DOI
2018 Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages.
DOI Scopus90 WoS89 Europe PMC79
2017 Selth, L., Das, R., Townley, S., Coutinho, I., Hanson, A., Centenera, M., . . . Tilley, W. (2017). A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer. Oncogene, 36(1), 24-34.
DOI Scopus95 WoS94 Europe PMC85
2017 Das, R., Gregory, P. A., Fernandes, R. C., Denis, I., Wang, Q., Townley, S. L., . . . Selth, L. A. (2017). MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2. Cancer Research, 77(4), 1021-1034.
DOI Scopus103 WoS103 Europe PMC91
2017 Tse, B., Volpert, M., Ratther, E., Stylianou, N., Nouri, M., McGowan, K., . . . Hollier, B. (2017). Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene, 36(24), 3417-3427.
DOI Scopus65 WoS67 Europe PMC60
2017 Cursons, J., Pillman, K., Scheer, K., Gregory, P., Foroutan, M., Zadeh, S. H., . . . Davis, M. (2017). Post-transcriptional control of EMT is coordinated through combinatorial targeting by multiple microRNAs.
DOI
2015 Conn, S., Pillman, K., Toubia, J., Conn, V., Salmanidis, M., Phillips, C., . . . Goodall, G. (2015). The RNA binding protein quaking regulates formation of circRNAs. Cell, 160(6), 1125-1134.
DOI Scopus1814 WoS1720 Europe PMC1655
2014 Das, R., Gregory, P., Hollier, B., Tilley, W., & Selth, L. (2014). Epithelial plasticity in prostate cancer: principles and clinical perspectives. Trends in Molecular Medicine, 20(11), 643-651.
DOI Scopus22 WoS22 Europe PMC21
2014 Young, J. A., Ting, K. K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. R. (2014). Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919)). Blood, 124(19), 3034.
DOI
2014 Zafar, A., Wu, F., Hardy, K., Li, J., Juan Tu, W., McCuaig, R., . . . Rao, S. (2014). Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells. Molecular and Cellular Biology, 34(16), 2961-2980.
DOI Scopus33 WoS33 Europe PMC33
2014 Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., . . . Goodall, G. (2014). Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. The EMBO Journal, 33(18), 1979-2134.
DOI Scopus124 WoS121 Europe PMC115
2014 Kolesnikoff, N., Attema, J., Roslan, S., Bert, A., Schwarz, Q., Gregory, P., & Goodall, G. (2014). Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. Journal of Biological Chemistry, 289(16), 11194-11205.
DOI Scopus61 WoS57 Europe PMC53
2014 Yip, K., Kolesnikoff, N., Yu, C., Hauschild, N., Taing, H., Biggs, L., . . . Grimbaldeston, M. (2014). Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation. Journal of Allergy and Clinical Immunology, 133(5), 1356-1379.
DOI Scopus102 WoS89 Europe PMC78
2014 Li, X., Roslan, S., Johnstone, C., Wright, J., Bracken, C., Anderson, M., . . . Khew-Goodall, Y. (2014). MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene, 33(31), 4077-4088.
DOI Scopus109 WoS103 Europe PMC102
2013 Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. (2013). Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919.
DOI Scopus62 WoS61 Europe PMC56
2013 Lim, Y., Wright, J., Attema, J., Gregory, P., Bert, A., Smith, E., . . . Goodall, G. (2013). Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. Journal of Cell Science, 126(10), 2256-2266.
DOI Scopus173 WoS157 Europe PMC153
2013 Neilsen, P., Noll, J., Mattiske, S., Bracken, C., Gregory, P., Schulz, R., . . . Callen, D. (2013). Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene, 32(24), 2992-3000.
DOI Scopus154 WoS143 Europe PMC137
2013 Yu, Y., Gray, B., Lowe, H., Halmagyi, G. M., & Ng, M. (2013). Dual modality intravascular imaging of unstable, symptomatic but "hemodynamically insignificant" carotid stenosis. Journal of Neurology, 260(7), 1934-1935.
DOI
2012 Ahn, Y., Gibbons, D., Chakravarti, D., Creighton, C., Rizvi, Z., Adams, H., . . . Kurie, J. (2012). ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. Journal of Clinical Investigation, 122(9), 3170-3183.
DOI Scopus143 WoS141 Europe PMC135
2012 Callegari, S., Gregory, P., Sykes, M., Bellon, J., Andrews, S., McKinnon, R., & de Barros Lopes, M. (2012). Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity. PLoS Genetics, 8(6), 1-12.
DOI Scopus6 WoS6 Europe PMC5
2011 Matsushima, K., Isomoto, H., Yamaguchi, N., Inoue, N., Machida, H., Nakayama, T., . . . Nakao, K. (2011). MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. Journal of Translational Medicine, 9(30), 1-12.
DOI Scopus131 WoS124 Europe PMC108
2011 Gregory, P., Bracken, C., Smith, E., Bert, A., Wright, J., Roslan, S., . . . Goodall, G. (2011). An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Molecular Biology of the Cell, 22(10), 1686-1698.
DOI Scopus510 WoS478 Europe PMC461
2011 Yang, Y., Ahn, Y., Gibbons, D., Zang, Y., Lin, W., Thilaganathan, N., . . . Kurie, J. (2011). The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. Journal of Clinical Investigation, 121(4), 1373-1385.
DOI Scopus186 WoS171 Europe PMC158
2010 Hu, D., Gardner-Stephen, D., Severi, G., Gregory, P., Treloar, J., Giles, G., . . . MacKenzie, P. (2010). A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide. Molecular Pharmacology, 78(4), 714-722.
DOI Scopus28 WoS26 Europe PMC26
2009 Gibbons, D., Lin, W., Creighton, C., Rizvi, Z., Gregory, P., Goodall, G., . . . Kurie, J. (2009). Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes & Development, 23(18), 2140-2151.
DOI Scopus454 WoS429 Europe PMC400
2009 Bracken, C., Gregory, P., Khew-Goodall, Y., & Goodall, G. (2009). The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cellular and Molecular Life Sciences, 66(10), 1682-1699.
DOI Scopus107 WoS96 Europe PMC90
2008 Paterson, E., Kolesnikoff, N., Gregory, P., Bert, A., Khew-Goodall, Y., & Goodall, G. (2008). The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition. The Scientific World Journal, 8, 901-904.
DOI Scopus76 WoS72 Europe PMC61
2008 Gregory, P., Bracken, C., Bert, A., & Goodall, G. (2008). MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle, 7(20), 3112-3117.
DOI Scopus449 WoS413 Europe PMC380
2008 Bracken, C., Gregory, P., Kolesnikoff, N., Bert, A., Wang, J., Shannon, M., & Goodall, G. (2008). A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Research, 68(19), 7846-7854.
DOI Scopus959 WoS907 Europe PMC856
2008 Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., . . . Goodall, G. (2008). The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601.
DOI Scopus3458 WoS3254 Europe PMC2975
2006 Gregory, P. A., Gardner-Stephen, D. A., Rogers, A., Michael, M. Z., & Mackenzie, P. I. (2006). The caudal-related homeodomain protein Cdx2 and hepatocyte nuclear factor 1α cooperatively regulate the UDP-glucuronosyltransferase 2B7 gene promoter. Pharmacogenetics and Genomics, 16(7), 527-536.
DOI Scopus21 WoS18 Europe PMC16
2005 Mackenzie, P., Gregory, P., Lewinsky, R., Yasmin, S., Crittenden, T. A., McKinnon, R. A., & Gardner Stephen, D. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases. Toxicology and Applied Pharmacology, 207(2 SUPPL.), 77-83.
DOI Scopus39 Europe PMC27
2005 Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. Methods in Enzymology, 400, 22-46.
DOI Scopus16 Europe PMC13
2004 Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., & Mackenzie, P. I. (2004). Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Toxicology and Applied Pharmacology, 199(3), 354-363.
DOI Scopus109 WoS104 Europe PMC88
2004 Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., & Mackenzie, P. I. (2004). Coordinate Regulation of the Human UDP-Glucuronosyltransferase 1A8, 1A9, and 1A10 Genes by Hepatocyte Nuclear Factor 1α and the Caudal-Related Homeodomain Protein 2. Molecular Pharmacology, 65(4), 953-963.
DOI Scopus69 WoS62 Europe PMC53
2003 Mackenzie, P. I., Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Jorgensen, B. R., Nishiyama, T., . . . Radominska-Pandya, A. (2003). Regulation of UDP glucuronosyltransferase genes. Current Drug Metabolism, 4(3), 249-257.
DOI Scopus107 WoS95 Europe PMC79
2003 Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Duncliffe, K. N., & Mackenzie, P. I. (2003). Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: Differential regulation through an initiator-like region. Journal of Biological Chemistry, 278(38), 36107-36114.
DOI Scopus27 WoS25 Europe PMC20
2002 Gregory, P. A., & Mackenzie, P. I. (2002). The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1α-mediated activation of the UDP-glucuronosyltransferase 2B17 gene. Molecular Pharmacology, 62(1), 154-161.
DOI Scopus29 WoS27 Europe PMC18
2000 Gregory, P. A., Hansen, A. J., & Mackenzie, P. I. (2000). Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics, 10(9), 809-820.
DOI Scopus32 WoS29 Europe PMC20

Year Citation
2013 Lecce, L., Lam, Y. T., & Ng, M. K. C. (2013). Role of sex steroids in angiogenesis. In Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 159-180). Springer New York.
DOI Scopus2
2013 Dunn, L. L., Chan, K. H., Ng, M. K. C., & Stocker, R. (2013). Vascular complications in diabetes. In Angiogenesis and Vascularisation Cellular and Molecular Mechanisms in Health and Diseases (pp. 313-337). Springer Vienna.
DOI
2005 Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. In H. Sies, & L. Packer (Eds.), PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS (Vol. 400, pp. 22-46). ELSEVIER ACADEMIC PRESS INC.
DOI WoS17

Year Citation
2013 Hirsh, S. L., Bilek, M. M. M., Bax, D. V., Kondyurin, A., Kosobrodova, E., Tsoutas, K., . . . Weiss, A. S. (2013). Ion implanted, radical-rich surfaces for the rapid covalent immobilization of active biomolecules. In Aip Conference Proceedings Vol. 1525 (pp. 364-369). AIP.
DOI Scopus4
2012 Javadzadegan, A., Yong, A. S. C., Chang, M., Mansour, N., Ng, M. K. C., Behnia, M., & Kritharides, L. (2012). Comparison of four different fluid structure interaction models in a human coronary artery. In Proceedings of the 18th Australasian Fluid Mechanics Conference Afmc 2012.
2004 Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., . . . Ritter, J. K. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. In Drug Metabolism and Disposition Vol. 32 (pp. 281-290). Netherlands: ELSEVIER SCIENCE INC.
DOI Scopus232 WoS186 Europe PMC157

Year Citation
2011 Rizvi, Z. H., Kurie, J. M., Gibbons, D. L., Ann, Y. H., Creighton, C. J., Maria Cabanillas, A., . . . Gregory, P. A. (2011). The scribble polarity complex regulates tumor cell invasion by regulation of Zeb1 and dampening of p1-integrin signaling. Poster session presented at the meeting of Abstracts from the 2010 MRS-AACR Joint Conference on Metastasis, as published in Clinical & Experimental Metastasis. Philadelphia, PA: Springer.
DOI
2011 Gibbons, D. L., Yang, Y., Ahn, Y. -H., Creighton, C. J., Pertsemlidis, A., Gregory, P. A., . . . Kurie, J. M. (2011). NOTCH ACTIVATION DRIVES MICRORNA-200-DEPENDENT EMT & METASTASIS IN A MURINE MODEL OF NSCLC. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS.
2011 Gibbons, D. L., Yang, Y., Ahn, Y. H., Creighton, C. J., Pertsemlidis, A., Gregory, P. A., . . . Kurie, J. M. (2011). EMT and metastasis in a murine model of NSCLC is dependent upon the Notch ligand Jagged2 activation of a GATA3-miR-200 feedback loop. Poster session presented at the meeting of Abstracts from the 2010 MRS-AACR Joint Conference on Metastasis, as published in Clinical & Experimental Metastasis. Philadelphia, PA: Springer.
DOI
2008 Gregory, P. A., Bracken, C. P., Bert, A. G., Paterson, E. L., Kolesnikoff, N., Farshid, G., . . . Goodall, G. J. (2008). Role of the miR-200 family in mediating EMT in response to TGF-β. Poster session presented at the meeting of Abstracts and Reviews of 7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, as published in Cytokine. Montreal, Canada: Elsevier.
DOI

Year Citation
2024 Kachooei, S. A., Bracken, J., Pillman, K., Gregory, P., & Bracken, C. (2024). More than half of annotated human miRNAs are never expressed at levels sufficient for biological function.
DOI
2022 Neumann, D., Pillman, K., Dredge, K., Bert, A., Bracken, C., Hollier, B., . . . Gregory, P. (2022). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking.
DOI

  • Characterising an RNA splicing pathway driving prostate cancer metastasis and therapy resistance, NHMRC - Project Grant, 01/01/2019 - 31/12/2022

  • Use of a new molecule (miR-342) to discover important pathways to treat advanced breast cancer, NBCF - Investigator Initiated Research Scheme, 01/01/2018 - 01/07/2021

  • Characterising novel alternative splicing networks that promote tumour cell plasticity, NHMRC - Project Grant, 01/01/2017 - 31/12/2019

  • Role of the microRNA target Quaking in alternative splicing during EMT and cancer progression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017

  • Targeting microRNA-driven mesenchymal to epithelial transition to suppress prostate cancer metastasis, NHMRC - Project Grant, 01/01/2015 - 31/12/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor Discovery of alternative splicing events that drive lethal castrate resistant prostate cancer Doctor of Philosophy Doctorate Full Time Miss Hongyu Li
2025 Principal Supervisor Discovery of alternative splicing events that drive lethal castrate resistant prostate cancer Doctor of Philosophy Doctorate Full Time Miss Hongyu Li
2025 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Josefanny Josefanny
2024 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Mr Bukuru Dieu-Donne Nturubika
2023 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Miss Jasleen Rajpal
2022 Co-Supervisor - Doctor of Philosophy Doctorate Full Time Saba Ataei Kachooei
2022 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Miss Shruti Tushar Deshpande
2022 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Miss Yesha Ramani

Date Role Research Topic Program Degree Type Student Load Student Name
2014 - 2016 Co-Supervisor The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis Doctor of Philosophy Doctorate Full Time Dr Rajdeep Das
2013 - 2014 Co-Supervisor Novel Fibroblast Growth Factor Receptor Signalling Pathways Regulating Neuronal Differentiation Master of Philosophy (Medical Science) Master Full Time Dr Yang Kong
2012 - 2017 Co-Supervisor A Role for Bivalent Genes in Epithelial to Mesenchymal Transition Doctor of Philosophy Doctorate Part Time Mr Francisco Sadras
2012 - 2024 Co-Supervisor Regulation of Breast Cancer Progression and Metastasis by MicroRNA-342-3p Doctor of Philosophy Doctorate Part Time Dr Victoria Kiriaki Arnet
2010 - 2012 Co-Supervisor The miR 200 Family is Controlled by Epigenetic based Mechanisms and Mediates Transition Between Non Stem and Stem like Cell Phenotypes Doctor of Philosophy Doctorate Full Time Mr Yat Yuen Lim
2008 - 2013 Co-Supervisor Regulation of the microRNA-200 family during epithelial to mesenchymal transition Doctor of Philosophy Doctorate Full Time Miss Natasha Kolesnikoff Prizzi

Connect With Me

External Profiles

Other Links