Philip Gregory

Adelaide Medical School

Faculty of Health and Medical Sciences

Asoociate Professor Philip Gregory
Head, Gene Regulation in Cancer Laboratory
Centre for Cancer Biology: An Alliance between University of South Australia and SA Pathology.

A/Prof Philip Gregory is researching the new and exciting area of ‘microRNAs’. These are tiny particles of genetic material that exist inside cells and regulate how our genes are switched on and off. MicroRNAs were only discovered relatively recently and their role in the development of breast cancer is just beginning to be explored.

A/Prof Gregory is interested in how microRNAs influence breast and prostate cancer cells to spread to other parts of the body – a process known as metastasis. Metastatic (or secondary) breast cancer is currently very difficult to treat effectively, so understanding how metastasis occurs could lead to the development of more effective treatments and improved prevention strategies.

Epithelial cell plasticity (or epithelial-mesenchymal transition, EMT) plays a major role in the driving cancer cell invasion and their metastasis to other organs. My lab is examining how EMT and cancer metastasis are regulated by microRNAs. In particular, our research focusses on how microRNAs alter the cancer cell transcriptome using in vitro and in vivo cancer models coupled with next generation sequencing.

My Research
Career
Publications
Grants and Funding
Supervision
Contact

Gene Regulation in Cancer Laboratory

The Gene Regulation in Cancer Laboratory within the Centre for Cancer Biology investigates the molecular mechanisms controlling tumour cell plasticity in breast and prostate cancer, with a specific focus on the role of microRNAs and alternative splicing in this process. A/Prof. Gregory's groundbreaking research identified the miR-200 family as central regulators of epithelial-mesenchymal transition (Nature Cell Biology, >3000 citations). His lab uses the latest advances in transcriptomics coupled with in vitro and in vivo cancer models to investigate how cancer cells progress towards a metastatic state.

Project 1

Title: Function of alternative splice variants in cancer cell plasticity

Description: Using CRISPR gene editing, this project will uncover the function of alternatively spliced variants that are strongly induced in invasive cancer cells but whose function has not yet been investigated.

Projects available for: Honours and HDR

Location: Centre for Cancer Biology

Research Project Start: Semester 1 and 2

Project 2

Title: How microRNAs regulate breast cancer metastasis

Description: This project will determine the target genes of miRNAs that function in breast cancer progression and metastasis using cell culture and animal models.

Projects available for: Honours and HDR

Location: Centre for Cancer Biology

Research Project Start: Semester 1 and 2

Appointments

Date Position Institution name

2015 - ongoing Laboratory Head Centre for Cancer Biology
Education

Date Institution name Country Title

2005 Flinders University Australia Doctor of Philosophy

1997 Flinders University Australia Bachelor of Biotechnology (Honours)
Research Interests

Biochemistry & Molecular Biology Cancer Cell Biology Genomics Cancer Biology and Clinical Oncology

Date	Position	Institution name
2015 - ongoing	Laboratory Head	Centre for Cancer Biology

Date	Institution name	Country	Title
2005	Flinders University	Australia	Doctor of Philosophy
1997	Flinders University	Australia	Bachelor of Biotechnology (Honours)

Journals

Year	Citation
2024	Liu, D., Dredge, B. K., Bert, A. G., Pillman, K. A., Toubia, J., Guo, W., . . . Goodall, G. J. (2024). ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic Acids Research, 52(3), 1387-1403. DOI Scopus2 Europe PMC3
2024	Neumann, D. P., Phillips, C. A., Lumb, R., Palethorpe, H. M., Ramani, Y., Hollier, B. G., . . . Gregory, P. A. (2024). Quaking isoforms cooperate to promote the mesenchymal phenotype. Molecular Biology of the Cell, 35(2), 12 pages. DOI Scopus1 Europe PMC1
2024	Neumann, D. P., Pillman, K. A., Dredge, B. K., Bert, A. G., Phillips, C. A., Lumb, R., . . . Gregory, P. A. (2024). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. RNA Biology, 21(1), 1-11. DOI Scopus2 Europe PMC2
2024	Thompson, E. J., Escarbe, S., Tvorogov, D., Farshid, G., Gregory, P. A., Khew-Goodall, Y., . . . Bonder, C. S. (2024). Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis. Growth Factors, 42(2), 49-61. DOI
2024	Bracken, C. P., Goodall, G. J., & Gregory, P. A. (2024). RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer. Seminars in Cancer Biology, 102-103, 4-16. DOI Scopus2
2024	Nturubika, B. D., Guardia, C. M., Gershlick, D. C., Logan, J. M., Martini, C., Heatlie, J. K., . . . Johnson, I. R. D. (2024). Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression. British Journal of Cancer, 131(8), 1263-1278. DOI
2023	Sapkota, S., Pillman, K. A., Dredge, B. K., Liu, D., Bracken, J. M., Kachooei, S. A., . . . Goodall, G. J. (2023). On the rules of engagement for microRNAs targeting protein coding regions. Nucleic Acids Research, 51(18), 9938-9951. DOI Scopus3
2023	Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17. DOI
2023	King, J. J., Evans, C. W., Kadolsky, U. D., Norret, M., Iqbal, M., Mercé, C., . . . Smith, N. M. (2023). Metastable Intermediates Identified in Epithelial to Mesenchymal Transition are Regulated by G-Quadruplex DNA Structures. DOI
2022	Tang, Y. H., Rockstroh, A., Sokolowski, K. A., Lynam, L. R., Lehman, M., Thompson, E. W., . . . Hollier, B. G. (2022). Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation. Breast Cancer Research, 24(1), 17 pages. DOI Scopus16 WoS8 Europe PMC9
2022	Neumann, D. P., Goodall, G. J., & Gregory, P. A. (2022). The Quaking RNA-binding proteins as regulators of cell differentiation. Wiley interdisciplinary reviews. RNA, 13(6), e1724-1-e1724-19. DOI Scopus19 WoS4 Europe PMC18
2022	Chi, L. H., Cross, R. S. N., Redvers, R. P., Davis, M., Hediyeh-Zadeh, S., Mathivanan, S., . . . Anderson, R. L. (2022). MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms. Oncogenesis, 11(1), 1-12. DOI Scopus12 WoS4 Europe PMC7
2021	Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., . . . Selth, L. A. (2021). Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer. Cell Reports, 34(1), 1-17. DOI Scopus32 WoS23 Europe PMC24
2021	Chan, K. M., Gleadle, J. M., Gregory, P. A., Phillips, C. A., Safizadeh Shirazi, H., Whiteley, A., . . . Macgregor, M. (2021). Selective microfluidic capture and detection of prostate cancer cells from urine without digital rectal examination. Cancers, 13(21), 5544-1-5544-17. DOI Scopus7 WoS5 Europe PMC4
2020	Saunders, K., Bert, A. G., Dredge, B. K., Toubia, J., Gregory, P. A., Pillman, K. A., . . . Bracken, C. P. (2020). Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing. Scientific Reports, 10(1), 1-9. DOI Scopus9 WoS5 Europe PMC8
2019	Pillman, K. A., Scheer, K. G., Hackett-Jones, E., Saunders, K., Bert, A. G., Toubia, J., . . . Bracken, C. P. (2019). Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA). Nucleic Acids Research, 47(16), 14 pages. DOI Scopus6 WoS5 Europe PMC4
2019	Gregory, P. A. (2019). The miR-200-Quaking axis functions in tumour angiogenesis. Oncogene, 38(41), 6767-6769. DOI Scopus4 WoS2 Europe PMC2
2019	Pinweha, P., Phillips, C. A., Gregory, P. A., Li, X., Chuayboonya, P., Mongkolsiri, P., . . . Jitrapakdee, S. (2019). MicroRNA-143-3p targets pyruvate carboxylase expression and controls proliferation and migration of MDA-MB-231 cells. Archives of Biochemistry and Biophysics, 677, 10 pages. DOI Scopus14 WoS15 Europe PMC8
2018	Cursons, J., Pillman, K. A., Scheer, K. G., Gregory, P. A., Foroutan, M., Hediyeh-Zadeh, S., . . . Davis, M. J. (2018). Combinatorial targeting by MicroRNAs co-ordinates post-transcriptional control of EMT. Cell Systems, 7(1), 77-91. DOI Scopus72 WoS58 Europe PMC47
2018	Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages. DOI Scopus80 WoS64 Europe PMC58
2018	Neumann, D. P., Goodall, G. J., & Gregory, P. A. (2018). Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity. Seminars in Cell and Developmental Biology, 75, 50-60. DOI Scopus20 WoS14 Europe PMC17
2017	Selth, L., Das, R., Townley, S., Coutinho, I., Hanson, A., Centenera, M., . . . Tilley, W. (2017). A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer. Oncogene, 36(1), 24-34. DOI Scopus91 WoS84 Europe PMC61
2017	Das, R., Gregory, P. A., Fernandes, R. C., Denis, I., Wang, Q., Townley, S. L., . . . Selth, L. A. (2017). MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2. Cancer Research, 77(4), 1021-1034. DOI Scopus97 WoS88 Europe PMC67
2017	Tse, B., Volpert, M., Ratther, E., Stylianou, N., Nouri, M., McGowan, K., . . . Hollier, B. (2017). Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene, 36(24), 3417-3427. DOI Scopus61 WoS53 Europe PMC46
2017	Cursons, J., Pillman, K., Scheer, K., Gregory, P., Foroutan, M., Zadeh, S. H., . . . Davis, M. (2017). Post-transcriptional control of EMT is coordinated through combinatorial targeting by multiple microRNAs. DOI
2015	Conn, S., Pillman, K., Toubia, J., Conn, V., Salmanidis, M., Phillips, C., . . . Goodall, G. (2015). The RNA binding protein quaking regulates formation of circRNAs. Cell, 160(6), 1125-1134. DOI Scopus1627 WoS1418 Europe PMC1212
2014	Das, R., Gregory, P., Hollier, B., Tilley, W., & Selth, L. (2014). Epithelial plasticity in prostate cancer: principles and clinical perspectives. Trends in Molecular Medicine, 20(11), 643-651. DOI Scopus21 WoS20 Europe PMC16
2014	Young, J. A., Ting, K. K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. R. (2014). Erratum: Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted mirna antagonists of mir-27 (Blood (2012) 122:16 (2911-2919)). Blood, 124(19), 3034. DOI
2014	Zafar, A., Wu, F., Hardy, K., Li, J., Juan Tu, W., McCuaig, R., . . . Rao, S. (2014). Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells. Molecular and Cellular Biology, 34(16), 2961-2980. DOI Scopus31 WoS30 Europe PMC26
2014	Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., . . . Goodall, G. (2014). Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. The EMBO Journal, 33(18), 1979-2134. DOI Scopus121 WoS116 Europe PMC94
2014	Kolesnikoff, N., Attema, J., Roslan, S., Bert, A., Schwarz, Q., Gregory, P., & Goodall, G. (2014). Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. Journal of Biological Chemistry, 289(16), 11194-11205. DOI Scopus59 WoS52 Europe PMC41
2014	Yip, K., Kolesnikoff, N., Yu, C., Hauschild, N., Taing, H., Biggs, L., . . . Grimbaldeston, M. (2014). Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation. Journal of Allergy and Clinical Immunology, 133(5), 1356-1379. DOI Scopus97 WoS84 Europe PMC62
2014	Li, X., Roslan, S., Johnstone, C., Wright, J., Bracken, C., Anderson, M., . . . Khew-Goodall, Y. (2014). MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. Oncogene, 33(31), 4077-4088. DOI Scopus105 WoS93 Europe PMC82
2013	Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., . . . Gamble, J. (2013). Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. DOI Scopus60 WoS54 Europe PMC43
2013	Lim, Y., Wright, J., Attema, J., Gregory, P., Bert, A., Smith, E., . . . Goodall, G. (2013). Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. Journal of Cell Science, 126(10), 2256-2266. DOI Scopus170 WoS154 Europe PMC129
2013	Neilsen, P., Noll, J., Mattiske, S., Bracken, C., Gregory, P., Schulz, R., . . . Callen, D. (2013). Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene, 32(24), 2992-3000. DOI Scopus146 WoS127 Europe PMC109
2013	Yu, Y., Gray, B., Lowe, H., Halmagyi, G. M., & Ng, M. (2013). Dual modality intravascular imaging of unstable, symptomatic but "hemodynamically insignificant" carotid stenosis. Journal of Neurology, 260(7), 1934-1935. DOI
2012	Ahn, Y., Gibbons, D., Chakravarti, D., Creighton, C., Rizvi, Z., Adams, H., . . . Kurie, J. (2012). ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. Journal of Clinical Investigation, 122(9), 3170-3183. DOI Scopus138 WoS132 Europe PMC121
2012	Callegari, S., Gregory, P., Sykes, M., Bellon, J., Andrews, S., McKinnon, R., & de Barros Lopes, M. (2012). Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity. PLoS Genetics, 8(6), 1-12. DOI Scopus5 WoS5 Europe PMC2
2011	Matsushima, K., Isomoto, H., Yamaguchi, N., Inoue, N., Machida, H., Nakayama, T., . . . Nakao, K. (2011). MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. Journal of Translational Medicine, 9(30), 1-12. DOI Scopus128 WoS118 Europe PMC87
2011	Gregory, P., Bracken, C., Smith, E., Bert, A., Wright, J., Roslan, S., . . . Goodall, G. (2011). An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Molecular Biology of the Cell, 22(10), 1686-1698. DOI Scopus488 WoS436 Europe PMC385
2011	Yang, Y., Ahn, Y., Gibbons, D., Zang, Y., Lin, W., Thilaganathan, N., . . . Kurie, J. (2011). The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. Journal of Clinical Investigation, 121(4), 1373-1385. DOI Scopus175 WoS159 Europe PMC128
2010	Hu, D., Gardner-Stephen, D., Severi, G., Gregory, P., Treloar, J., Giles, G., . . . MacKenzie, P. (2010). A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide. Molecular Pharmacology, 78(4), 714-722. DOI Scopus28 WoS26 Europe PMC23
2009	Gibbons, D., Lin, W., Creighton, C., Rizvi, Z., Gregory, P., Goodall, G., . . . Kurie, J. (2009). Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes & Development, 23(18), 2140-2151. DOI Scopus435 WoS383 Europe PMC345
2009	Bracken, C., Gregory, P., Khew-Goodall, Y., & Goodall, G. (2009). The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cellular and Molecular Life Sciences, 66(10), 1682-1699. DOI Scopus107 WoS94 Europe PMC79
2008	Paterson, E., Kolesnikoff, N., Gregory, P., Bert, A., Khew-Goodall, Y., & Goodall, G. (2008). The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition. The Scientific World Journal, 8, 901-904. DOI Scopus76 WoS69 Europe PMC53
2008	Gregory, P., Bracken, C., Bert, A., & Goodall, G. (2008). MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle, 7(20), 3112-3117. DOI Scopus435 WoS393 Europe PMC325
2008	Bracken, C., Gregory, P., Kolesnikoff, N., Bert, A., Wang, J., Shannon, M., & Goodall, G. (2008). A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Research, 68(19), 7846-7854. DOI Scopus929 WoS846 Europe PMC744
2008	Gregory, P., Bert, A., Paterson, E., Barry, S., Tsykin, A., Farshid, G., . . . Goodall, G. (2008). The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nature Cell Biology, 10(5), 593-601. DOI Scopus3352 WoS3067 Europe PMC2612
2006	Gregory, P. A., Gardner-Stephen, D. A., Rogers, A., Michael, M. Z., & Mackenzie, P. I. (2006). The caudal-related homeodomain protein Cdx2 and hepatocyte nuclear factor 1α cooperatively regulate the UDP-glucuronosyltransferase 2B7 gene promoter. Pharmacogenetics and Genomics, 16(7), 527-536. DOI Scopus20 WoS18 Europe PMC14
2005	Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. Methods in Enzymology, 400, 22-46. DOI Scopus16 Europe PMC8
2004	Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., & Mackenzie, P. I. (2004). Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Toxicology and Applied Pharmacology, 199(3), 354-363. DOI Scopus108 WoS101 Europe PMC73
2004	Gregory, P. A., Lewinsky, R. H., Gardner-Stephen, D. A., & Mackenzie, P. I. (2004). Coordinate Regulation of the Human UDP-Glucuronosyltransferase 1A8, 1A9, and 1A10 Genes by Hepatocyte Nuclear Factor 1α and the Caudal-Related Homeodomain Protein 2. Molecular Pharmacology, 65(4), 953-963. DOI Scopus69 WoS62 Europe PMC45
2003	Mackenzie, P. I., Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Jorgensen, B. R., Nishiyama, T., . . . Radominska-Pandya, A. (2003). Regulation of UDP glucuronosyltransferase genes. Current Drug Metabolism, 4(3), 249-257. DOI Scopus104 WoS93 Europe PMC67
2003	Gregory, P. A., Gardner-Stephen, D. A., Lewinsky, R. H., Duncliffe, K. N., & Mackenzie, P. I. (2003). Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: Differential regulation through an initiator-like region. Journal of Biological Chemistry, 278(38), 36107-36114. DOI Scopus27 WoS25 Europe PMC17
2002	Gregory, P. A., & Mackenzie, P. I. (2002). The homeodomain Pbx2-Prep1 complex modulates hepatocyte nuclear factor 1α-mediated activation of the UDP-glucuronosyltransferase 2B17 gene. Molecular Pharmacology, 62(1), 154-161. DOI Scopus29 WoS26 Europe PMC15
2000	Gregory, P. A., Hansen, A. J., & Mackenzie, P. I. (2000). Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter. Pharmacogenetics, 10(9), 809-820. DOI Scopus32 WoS28 Europe PMC16

Book Chapters

Year	Citation
2013	Lecce, L., Lam, Y. T., & Ng, M. K. C. (2013). Role of sex steroids in angiogenesis. In Biochemical Basis and Therapeutic Implications of Angiogenesis (pp. 159-180). Springer New York. DOI Scopus1
2013	Dunn, L. L., Chan, K. H., Ng, M. K. C., & Stocker, R. (2013). Vascular complications in diabetes. In Angiogenesis and Vascularisation: Cellular and Molecular Mechanisms in Health and Diseases (pp. 313-337). Springer Vienna. DOI
2005	Gardner-Stephen, D. A., Gregory, P. A., & Mackenzie, P. I. (2005). Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes. In H. Sies, & L. Packer (Eds.), PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS (Vol. 400, pp. 22-46). ELSEVIER ACADEMIC PRESS INC. DOI WoS17

Conference Papers

Year	Citation
2018	Gomez, G. A., Woodcock, J. M., Tergaonkar, V., & Gregory, P. A. (2018). Meeting Report: The 8th Barossa Meeting - Cell Signaling in Cancer Medicine in the Barossa Valley, Australia. In Cell Death and Disease Vol. 9 (pp. 3 pages). England: SPRINGERNATURE. DOI
2013	Hirsh, S. L., Bilek, M. M. M., Bax, D. V., Kondyurin, A., Kosobrodova, E., Tsoutas, K., . . . Weiss, A. S. (2013). Ion implanted, radical-rich surfaces for the rapid covalent immobilization of active biomolecules. In AIP Conference Proceedings Vol. 1525 (pp. 364-369). AIP. DOI Scopus4
2012	Javadzadegan, A., Yong, A. S. C., Chang, M., Mansour, N., Ng, M. K. C., Behnia, M., & Kritharides, L. (2012). Comparison of four different fluid structure interaction models in a human coronary artery. In Proceedings of the 18th Australasian Fluid Mechanics Conference, AFMC 2012.
2005	Mackenzie, P. I., Gregory, P. A., Lewinsky, R. H., Yasmin, S. N., Height, T., McKinnon, R. A., & Gardner-Stephen, D. A. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases. In Toxicology and Applied Pharmacology Vol. 207 (pp. 77-83). United States: Elsevier BV. DOI Scopus39 Europe PMC20
2004	Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., . . . Ritter, J. K. (2004). Glucuronidation and the UDP-glucuronosyltransferases in health and disease. In Drug Metabolism and Disposition Vol. 32 (pp. 281-290). United States: AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS. DOI Scopus222 WoS175 Europe PMC124

Conference Items

Year	Citation
2011	Rizvi, Z. H., Kurie, J. M., Gibbons, D. L., Ann, Y. H., Creighton, C. J., Maria Cabanillas, A., . . . Gregory, P. A. (2011). The scribble polarity complex regulates tumor cell invasion by regulation of Zeb1 and dampening of p1-integrin signaling. Poster session presented at the meeting of Abstracts from the 2010 MRS-AACR Joint Conference on Metastasis, as published in Clinical & Experimental Metastasis. Philadelphia, PA: Springer. DOI
2011	Gibbons, D. L., Yang, Y., Ahn, Y. -H., Creighton, C. J., Pertsemlidis, A., Gregory, P. A., . . . Kurie, J. M. (2011). NOTCH ACTIVATION DRIVES MICRORNA-200-DEPENDENT EMT & METASTASIS IN A MURINE MODEL OF NSCLC. Poster session presented at the meeting of JOURNAL OF THORACIC ONCOLOGY. LIPPINCOTT WILLIAMS & WILKINS.
2011	Gibbons, D. L., Yang, Y., Ahn, Y. H., Creighton, C. J., Pertsemlidis, A., Gregory, P. A., . . . Kurie, J. M. (2011). EMT and metastasis in a murine model of NSCLC is dependent upon the Notch ligand Jagged2 activation of a GATA3-miR-200 feedback loop. Poster session presented at the meeting of Abstracts from the 2010 MRS-AACR Joint Conference on Metastasis, as published in Clinical & Experimental Metastasis. Philadelphia, PA: Springer. DOI
2008	Gregory, P. A., Bracken, C. P., Bert, A. G., Paterson, E. L., Kolesnikoff, N., Farshid, G., . . . Goodall, G. J. (2008). Role of the miR-200 family in mediating EMT in response to TGF-β. Poster session presented at the meeting of Abstracts and Reviews of 7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, as published in Cytokine. Montreal, Canada: Elsevier. DOI

Preprint

Year	Citation
2022	Neumann, D., Pillman, K., Dredge, K., Bert, A., Bracken, C., Hollier, B., . . . Gregory, P. (2022). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. DOI

1. GREGORY PA (CIA) Discovery of optimal targets to better diagnose and treat metastatic cancer. Beat Cancer Principal Research Fellowship. Funding for 2019-2021.

2. GREGORY PA (CIA), Goodall GJ, Hollier BG Characterising an RNA splicing pathway driving prostate cancer metastasis and therapy resistance. NHMRC Project Grant APP1164669. Funding for 2019-2021.

3. GREGORY PA (CIA), Anderson RL, Goodall GJ miR-342 – a novel suppressor of a pro-metastatic gene network in triple-negative breast cancer. National Breast Cancer Foundation IIRS-18-147. Funding for 2018-2020.

4. GREGORY PA (CIA), Goodall GJ Characterising novel alternative splicing networks that promote tumour cell plasticity. NHMRC Project Grant APP1128479. Funding for 2017-2019.

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2014 - 2016	Co-Supervisor	The Role of microRNA-194 and microRNA-375 in Prostate Cancer Metastasis	Doctor of Philosophy	Doctorate	Full Time	Dr Rajdeep Das
2013 - 2014	Co-Supervisor	Novel Fibroblast Growth Factor Receptor Signalling Pathways Regulating Neuronal Differentiation	Master of Philosophy (Medical Science)	Master	Full Time	Dr Yang Kong
2012 - 2017	Co-Supervisor	A Role for Bivalent Genes in Epithelial to Mesenchymal Transition	Doctor of Philosophy	Doctorate	Part Time	Mr Francisco Sadras
2012 - 2024	Co-Supervisor	Regulation of Breast Cancer Progression and Metastasis by MicroRNA-342-3p	Doctor of Philosophy	Doctorate	Part Time	Dr Victoria Kiriaki Arnet
2010 - 2012	Co-Supervisor	The miR 200 Family is Controlled by Epigenetic based Mechanisms and Mediates Transition Between Non Stem and Stem like Cell Phenotypes	Doctor of Philosophy	Doctorate	Full Time	Mr Yat Yuen Lim
2008 - 2013	Co-Supervisor	Regulation of the microRNA-200 family during epithelial to mesenchymal transition	Doctor of Philosophy	Doctorate	Full Time	Miss Natasha Kolesnikoff

Email: philip.gregory@adelaide.edu.au

Philip Gregory

Appointments

Education

Research Interests