Paul Rolan

Research Interests

Neuroscience, Behaviour and Brain Health Indigenous and Disadvantaged Health Translational Health Outcomes Innovative Therapeutics Cellular Immunology Clinical Pharmacology and Therapeutics Pain

Prof Paul Rolan

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Professor Paul Rolan◾MBBS Adelaide (1978)◾Fellow of the Royal Australasian College of Physicians (General Medicine/Clinical Pharmacology) (1985)◾MD Adelaide (1995)◾Fellow of the Faculty of Pharmaceutical Medicine, United Kingdom (1997)◾Professor of Clinical Pharmacology, University of Adelaide (2005)◾Senior Consultant, Pain Management Unit, Royal Adelaide Hospital (2005)◾Fellow of the Faculty of Pain Medicine, Australian and New Zealand College of Anaesthetists (2014)◾Head of School of Medical Sciences (2014)◾ Director of Innovation, Faculty of Health Sciences (2016)Paul is a clinical pharmacologist, drug developer and pain management physician. After obtaining specialist qualifications in general medicine and clinical pharmacology he spent two years as Director of Medicine at Cairns Base Hospital. Subsequently Paul joined the pharmaceutical industry in the UK, initially working for Wellcome Research Laboratories where he was Head of Clinical Pharmacokinetics. In 1994 he became Medical Director of Medeval, a clinical pharmacology contract research organisation spun out of the University of Manchester. Under Paul's leadership, Medeval became the largest clinical pharmacology contract research organisation in the United Kingdom. He was part of a management buy out team of the Company from the University and a subsequent trade sale three years later to ICON Clinical Research. he has been Principal Investigator in over 700 clinical research studies and has been an active Consultant, both to the pharmaceutical industry as well as an invited speaker to the FDA.Paul returned to the University of Adelaide in 2005. His major clinical and academic interest is in chronic pain and headache, focusing on the development of biomarkers, evaluation of novel therapies and mechanisms of disease. Paul continues to advise on drug development for the international pharmaceutical industry.

Year Citation
2025 Rolan, P., Doolin, E., Paul, D., Crossman, J., Odontiadis, M., Danjou, P., . . . Papapetropoulos, S. (2025). The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease. Clinical Pharmacology in Drug Development, 12 pages.
DOI
2025 Hutchinson, M. R., Barratt, D., Johnston, C. H., Humphries, M. A., Semmler, C., Tettamanzi, G. C., . . . Rolan, P. (2025). Biomarkers to predict, prevent, and treat persistent pain: omics. Pain, 166(11S), S103-S105.
DOI
2025 Papapetropoulos, S., Doolin, E., O'Connor, S., Paul, D., Odontiadis, M., Jaros, M., . . . Stein, M. B. (2025). BNC210, an α7 Nicotinic Receptor Modulator, in Post-Traumatic Stress Disorder. Nejm Evidence, 4(1), 11 pages.
DOI Scopus3 WoS4 Europe PMC2
2025 Rolan, P., Seckl, J., Taylor, J., Harrison, J., Maruff, P., Woodward, M., . . . Hilt, D. (2025). Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease. Clinical Pharmacology in Drug Development, 14(2), 105-115.
DOI Scopus1 WoS1
2025 Papapetropoulos, S., Doolin, E., Odontiadis, M., Paul, D., Jaros, M., Rolan, P., . . . Stein, M. B. (2025). A phase 2, placebo-controlled study to evaluate the efficacy and safety of BNC210, an alpha-7 nicotinic receptor negative allosteric modulator, for acute, as-needed treatment of social anxiety disorder (SAD) – The PREVAIL study. Psychiatry Research, 346, 10 pages.
DOI Scopus4 WoS4 Europe PMC2
2025 Chen, K. K., Rolan, P., Hutchinson, M. R., & de Zoete, R. M. J. (2025). Reliability of Temporal Summation of Pain in Healthy and Clinical Populations: A Systematic Review and Meta-Analysis. European Journal of Pain, 29(8), 19 pages.
DOI Scopus1 WoS1 Europe PMC1
2024 Chen, K. K., Rolan, P., Hutchinson, M. R., Dickson, C., & de Zoete, R. M. J. (2024). Exercise-induced changes in central sensitization outcomes in individuals with chronic musculoskeletal pain: A systematic review with meta-analysis. European Journal of Pain, 28(9), 1431-1449.
DOI Scopus5 WoS6 Europe PMC3
2024 Crawford, G. B., Lakhani, A., Palmer, L., Sebalj, M., & Rolan, P. (2024). Breakthrough cancer pain management: mixed-methods study of health care professionals.. BMJ supportive & palliative care, 15(3), spcare-2024-004951.
DOI Scopus1 WoS1
2023 Crawford, G. B., Lakhani, A., Palmer, L., Sebalj, M., & Rolan, P. (2023). A systematic review of qualitative research exploring patient and health professional perspectives of breakthrough cancer pain.. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 31(12), 1-10.
DOI Scopus6 WoS5 Europe PMC4
2023 Chen, K. K., Hutchinson, M. R., Rolan, P., & de Zoete, R. M. J. (2023). Effect of exercise on chronic neck pain and central sensitization: A protocol for a randomized crossover trial.. Exp Physiol, 108(5), 672-682.
DOI Scopus4 WoS3 Europe PMC4
2021 Evans, S. F., Hull, M. L., Hutchinson, M. R., & Rolan, P. E. (2021). Androgens, Endometriosis and Pain.. Frontiers in reproductive health, 3, 792920-1-792920-7.
DOI Scopus13 WoS10 Europe PMC10
2021 Evans, S. F., Kwok, Y., Solterbeck, A., Pyragius, C., Hull, M. L., Hutchinson, M. R., & Rolan, P. (2021). The relationship between androgens and days per month of period pain, pelvic pain, headache, and TLR4 responsiveness of peripheral blood mononuclear cells in young women with dysmenorrhoea. Journal of Pain Research, 14, 585-599.
DOI Scopus14 WoS13 Europe PMC13
2020 Evans, S. F., Kwok, Y. H., Solterbeck, A., Liu, J., Hutchinson, M. R., Hull, M. L., & Rolan, P. E. (2020). Toll-like receptor responsiveness of peripheral blood mononuclear cells in young women with dysmenorrhea. Journal of Pain Research, 13, 503-516.
DOI Scopus10 WoS9 Europe PMC8
2019 Arthur, L., & Rolan, P. (2019). A systematic review of western medicine's understanding of pain experience, expression, assessment, and management for Australian Aboriginal and Torres Strait Islander Peoples. Pain Reports, 4(6), 9 pages.
DOI Scopus20 WoS18 Europe PMC14
2018 Gargett, T., Abbas, M., Rolan, P., Price, J., Gosling, K., Ferrante, A., . . . Brown, M. (2018). Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma. Cancer Immunology, Immunotherapy, 67(9), 1461-1472.
DOI Scopus86 WoS73 Europe PMC63
2018 Evans, S., Brooks, T., Esterman, A., Hull, M., & Rolan, P. (2018). The comorbidities of dysmenorrhea: A clinical survey comparing symptom profile in women with and without endometriosis. Journal of Pain Research, 11, 3181-3194.
DOI Scopus57 WoS51 Europe PMC30
2017 Nagpal, A., Juttner, C., Hamilton-Bruce, M., Rolan, P., & Koblar, S. (2017). Stem cell therapy clinical research: a regulatory conundrum for academia. Advanced Drug Delivery Reviews, 122, 105-114.
DOI Scopus12 WoS9 Europe PMC8
2016 Kwok, Y., Swift, J., Gazerani, P., & Rolan, P. (2016). A double-blind, randomized, placebo-controlled pilot trial to determine the efficacy and safety of ibudilast, a potential glial attenuator, in chronic migraine. Journal of Pain Research, 9, 899-907.
DOI Scopus30 WoS28 Europe PMC24
2016 Delacroix, S., Chokka, R., Nelson, A., Sidharta, S., Teo, K., Tuke, J., . . . Worthley, S. (2016). SAFETY AND EFFICACY OF PRO ANP 31-67 IN CARDIORENAL SYNDROME: A FIRST-IN-HUMAN TRIAL. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13), 1351.
DOI WoS2
2015 Stockis, A., Chanteux, H., Rosa, M., & Rolan, P. (2015). Brivaracetam and carbamazepine interaction in healthy subjects and in vitro. Epilepsy Research, 113, 19-27.
DOI Scopus51 Europe PMC36
2015 Johnson, J. L., & Rolan, P. E. (2015). Paradoxical topiramate-induced hyperphagia successfully treated with phentermine in a woman with migraine. Journal of clinical neuroscience, 22(8), 1363-1364.
DOI Scopus3 WoS2 Europe PMC3
2015 Rolan, P., O'Neill, G., Versage, E., Rana, J., Tang, Y., Galluppi, G., & Aycardi, E. (2015). First-in-human, double-blind, placebo-controlled, randomized, dose-escalation study of BG00010, a glial cell line-derived neurotrophic factor family member, in subjects with unilateral sciatica. PLoS One, 10(5), e0125034-1-e0125034-16.
DOI Scopus23 WoS22 Europe PMC20
2015 Johnson, J. L., Kwok, Y. H., Sumracki, N. M., Swift, J. E., Hutchinson, M. R., Johnson, K., . . . Rolan, P. E. (2015). Glial attenuation with ibudilast in the treatment of medication overuse headache: a double-blind, randomized, placebo-controlled pilot trial of efficacy and safety. Headache, 55(9), 1192-1208.
DOI Scopus21 WoS19 Europe PMC14
2015 Nenke, M., Haylock, C., Rankin, W., Inder, W., Gagliardi, L., Eldridge, C., . . . Torpy, D. (2015). Low-dose hydrocortisone replacement improves wellbeing and pain tolerance in chronic pain patients with opioid-induced hypocortisolemic responses. A pilot randomized, placebo-controlled trial. Psychoneuroendocrinology, 56, 157-167.
DOI Scopus27 WoS27 Europe PMC20
2014 Nicotra, L., Tuke, S., Grace, P., Rolan, P., & Hutchinson, M. (2014). Sex differences in mechanical allodynia: how can it be preclinically quantified and analyzed?. Frontiers in Behavioral Neuroscience, 8(February), 1-16.
DOI Scopus47 WoS45 Europe PMC42
2014 Sumracki, N., Buisman-Pijlman, F., Hutchinson, M., Gentgall, M., & Rolan, P. (2014). Reduced response to the thermal grill illusion in chronic pain patients. Pain Medicine, 15(4), 647-660.
DOI Scopus22 WoS21 Europe PMC19
2014 Rolan, P., Lim, S., Sunderland, V., Liu, Y., & Molnar, V. (2014). The absolute bioavailability of racemic ketamine from a novel sublingual formulation. British Journal of Clinical Pharmacology, 77(6), 1011-1016.
DOI Scopus38 WoS37 Europe PMC28
2014 Johnson, J., Rolan, P., Johnson, M., Bobrovskaya, L., Williams, D., Johnson, K., . . . Hutchinson, M. (2014). Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation. Translational Psychiatry, 4(e482), e482-1-e482-9.
DOI Scopus34 WoS32 Europe PMC32
2014 Rolan, P. (2014). Understanding the pharmacology of headache. Current Opinion in Pharmacology, 14(1), 30-33.
DOI Scopus6 WoS6 Europe PMC5
2013 Vallence, A., Smith, A., Tabor, A., Rolan, P., & Ridding, M. (2013). Chronic tension-type headache is associated with impaired motor learning. Cephalalgia, 33(12), 1048-1054.
DOI Scopus18 WoS18 Europe PMC13
2013 Hutchinson, M., Bujis, M., Tuke, S., Kwok, Y., Gentgall, M., Williams, D., & Rolan, P. (2013). Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection. Brain Behavior and Immunity, 30, 3-11.
DOI Scopus61 WoS58 Europe PMC53
2013 Kwok, Y., Tuke, S., Nicotra, L., Grace, P., Rolan, P., & Hutchinson, M. (2013). TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. PLoS One, 8(10), 1-16.
DOI Scopus21 WoS18 Europe PMC21
2013 Stockis, A., & Rolan, P. (2013). Effect of brivaracetam (400 mg/day) on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive in healthy women. The Journal of Clinical Pharmacology (Online), 53(12), 1313-1321.
DOI Scopus28 WoS28 Europe PMC23
2013 Maddison, J., Somogyi, A., Jensen, B., James, H., Gentgall, M., & Rolan, P. (2013). The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype. British Journal of Clinical Pharmacology, 75(1), 208-216.
DOI Scopus34 WoS30 Europe PMC26
2013 Johnson, J., Hutchinson, M., Williams, D., & Rolan, P. (2013). Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment. Cephalalgia, 33(1), 52-64.
DOI Scopus44 WoS41 Europe PMC32
2012 Rolan, P. (2012). Drug interactions with triptans which are clinically significant?. Cns Drugs, 26(11), 949-957.
DOI Scopus23 WoS17 Europe PMC17
2012 Kwok, Y., Hutchinson, M., Gentgall, M., & Rolan, P. (2012). Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients. PLoS One, 7(8), 1-8.
DOI Scopus52 WoS51 Europe PMC49
2012 Grace, P., Hurley, D., Barratt, D., Tsykin, A., Watkins, L., Rolan, P., & Hutchinson, M. (2012). Harnessing pain heterogeneity and RNA transcriptome to idenitfy blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic construction injury model. Journal of Neurochemistry, 122(5), 976-994.
DOI Scopus27 WoS27 Europe PMC23
2012 Sumracki, N., Hutchinson, M., Gentgall, M., Briggs, N., Williams, D., & Rolan, P. (2012). The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. PLoS One, 7(6), 1-8.
DOI Scopus20 WoS18 Europe PMC18
2012 Aykanat, V., Gentgall, M., Briggs, N., Williams, D., Yap, S., & Rolan, P. (2012). Intradermal capsaicin as a neuropathic pain model in patients with unilateral sciatica. British Journal of Clinical Pharmacology, 73(1), 37-45.
DOI Scopus16 WoS12 Europe PMC13
2012 Krishnan, S., Salter, A., Sullivan, T., Gentgall, M., White, J., & Rolan, P. (2012). Comparison of pain models to detect opioid-induced hyperalgesia. Journal of Pain Research, 2012(5), 99-106.
DOI Scopus28 Europe PMC25
2012 Rolan, P. (2012). A clinical pharmacologist's journey in pain research and treatment. PAIN MANAGEMENT, 2(3), 205-207.
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2011 Rolan, P. (2011). What to do about opioids for chronic noncancer pain? A perspective from Australia. PAIN MANAGEMENT, 1(6), 495-497.
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2011 Grace, P., Rolan, P., & Hutchinson, M. (2011). Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behavior and Immunity, 25(7), 1322-1332.
DOI Scopus99 WoS92 Europe PMC88
2011 Rolan, P., Sun, H., MacLeod, C., Bracken, K., & Evans, T. (2011). Pharmacokinetics and unexpected safety issues of LBM415, a novel oral peptide deformylase inhibitor. Clinical Pharmacology & Therapeutics, 90(2), 256-262.
DOI Scopus22 Europe PMC15
2011 Grace, P., Hutchinson, M., Bishop, A., Somogyi, A., Mayrhofer, G., & Rolan, P. (2011). Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain. Brain Behavior and Immunity, 25(3), 503-513.
DOI Scopus24 WoS22 Europe PMC21
2011 Rolan, P. (2011). The placebo response is part of good medicine. Clinical Pharmacology and Therapeutics, 89(4), 485.
DOI Scopus2 Europe PMC1
2010 Cathcart, S., Winefield, A., Lushington, K., & Rolan, P. (2010). Stress and tension-type headache mechanisms. Cephalalgia, 30(10), 1250-1267.
DOI Scopus71 WoS65 Europe PMC49
2010 Grace, P., Stanford, T., Gentgall, M., & Rolan, P. (2010). Utility of saccadic eye movement analysis as an objective biomarker to detect the sedative interaction between opioids and sleep deprivation in opioid-naive and opioid-tolerant populations. Journal of Psychopharmacology, 24(11), 1631-1640.
DOI Scopus27 WoS27 Europe PMC21
2010 Grace, P., Hutchinson, M., Manavis, J., Somogyi, A., & Rolan, P. (2010). A novel animal model of graded neuropathic pain: Utility to investigate mechanisms of population heterogeneity. Journal of Neuroscience Methods, 193(1), 47-53.
DOI Scopus47 WoS47 Europe PMC43
2010 Cathcart, S., Winefield, A., Lushington, K., & Rolan, P. (2010). Noxious inhibition of temporal summation is impaired in chronic tension-type headache. Headache, 50(3), 403-412.
DOI Scopus87 WoS83 Europe PMC68
2010 Cathcart, S., Petkov, J., Winefield, A., Lushington, K., & Rolan, P. (2010). Central mechanisms of stress-induced headache. Cephalalgia, 30(3), 285-295.
DOI Scopus57 WoS44 Europe PMC35
2009 Cathcart, S., Winefield, A., Rolan, P., & Lushington, K. (2009). Reliability of temporal summation and diffuse noxious inhibitory control. Pain Research & Management, 14(6), 433-438.
DOI Scopus150 WoS144 Europe PMC123
2009 Rolan, P., Hutchinson, M., & Johnson, K. (2009). Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy, 10(17), 2897-2904.
DOI Scopus146 WoS140 Europe PMC113
2009 Gustafsson, H., Akesson, J., Lau, C., Williams, D., Miller, L., Yap, S., & Rolan, P. (2009). A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers. British Journal of Clinical Pharmacology, 68(4), 511-517.
DOI Scopus10 WoS9 Europe PMC11
2009 Cathcart, S., Winefield, A., Lushington, K., & Rolan, P. (2009). Effect of mental stress on cold pain in chronic tension-type headache sufferers. The Journal of Headache and Pain, 10(5), 367-373.
DOI Scopus19 WoS18 Europe PMC12
2008 Rolan, P., Sargentini-Maier, M., Pigeolet, E., & Stockis, A. (2008). The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy men. British Journal of Clinical Pharmacology, 66(1), 71-75.
DOI Scopus128 Europe PMC91
2008 Rolan, P., Gibbons, J., He, L., Chang, E., Jones, D., Gross, M., . . . Johnson, K. (2008). Ibudilast in healthy volunteers: Safety, tolerability and pharmacokinetics with single and multiple doses. British Journal of Clinical Pharmacology, 66(6), 792-801.
DOI Scopus61 WoS61 Europe PMC61
2007 Rolan, P., Danhof, M., Stanski, D., & Peck, C. (2007). Current issues relating to drug safety especially with regard to the use of biomarkers: A meeting report and progress update. European Journal of Pharmaceutical Sciences, 30(2), 107-112.
DOI Scopus15 WoS10 Europe PMC6
2007 Sargentini-Maier, M., Rolan, P., Connell, J., Tytgat, D., Jacobs, T., Pigeolet, E., . . . Stockis, A. (2007). The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy males. British Journal of Clinical Pharmacology, 63(6), 680-688.
DOI Scopus113 WoS101 Europe PMC86
2004 Rolan, P. (2004). Pharmacokinetic studies in migraine: What questions should physicians ask?. Current Pain and Headache Reports, 8(3), 219-222.
DOI
2003 McAleer, S., Mills, R., Polack, R., Hussain, T., Rolan, P., Gibbs, A., . . . Hussein, F. (2003). Pharmacokinetics of high-dose buprenorphine following single administration of sublingual tablet formulations in opioid naive healthy male volunteers under a naltrexone block. Drug and Alcohol Dependence, 72(1), 75-83.
DOI Scopus51 Europe PMC42
2003 Ferron, G., Patat, A., Parks, V., Rolan, P., & Troy, S. (2003). Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady-state in healthy subjects. British Journal of Clinical Pharmacology, 56(1), 39-45.
DOI Scopus45 Europe PMC29
2003 Rolan, P., Terpstra, I., Clarke, C., Mullins, F., & Visser, J. (2003). A placebo-controlled pharmacodynamic and pharmacokinetic interaction study between tamsulosin and acenocoumarol. British Journal of Clinical Pharmacology, 55(3), 314-316.
DOI Scopus7 Europe PMC4
2002 Agerso, H., Jensen, L., Elbrond, B., Rolan, P., & Zdravkovic, M. (2002). The pharmacokinetics pharmacodynamics safety and tolerability of NN2211 a new long-acting GLP-1 derivative in healthy men. Diabetologia, 45(2), 195-202.
DOI Scopus514 Europe PMC376
2002 Elbrond, B., Jakobsen, G., Larsen, S., Agerso, H., Jensen, L., Rolan, P., . . . Zdravkovic, M. (2002). Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects. Diabetes Care, 25(8), 1398-1404.
DOI Scopus281 Europe PMC206
2002 De Bony, F., Tod, M., Bidault, R., On, N., Posner, J., & Rolan, P. (2002). Multiple Interactions of Cimetidine and Probenecid with Valaciclovir and Its Metabolite Acyclovir. Antimicrobial Agents and Chemotherapy, 46(2), 458-463.
DOI Scopus37 Europe PMC25
2001 Moller, S., Larsen, F., Khant, A., & Rolan, P. (2001). Lack of effect of citalopram on the steady-state pharmacokinetics of carbamazepine in healthy male subjects. Journal of Clinical Psychopharmacology, 21(5), 493-499.
DOI Scopus20 Europe PMC16
2001 Marcellin, P., De Bony, F., Garret, C., Altman, C., Boige, V., Castelnau, C., . . . Bidault, R. (2001). Influence of cirrhosis on lamotrigine pharmacokinetics. British Journal of Clinical Pharmacology, 51(5), 410-414.
DOI Scopus51 Europe PMC33
2001 Gordon, G., Chronicle, E., & Rolan, P. (2001). Why do we still not know whether refractive error causes headaches? Towards a framework for evidence based practice. Ophthalmic and Physiological Optics, 21(1), 45-50.
DOI Scopus25 Europe PMC9
2001 Ferron, G. M., Patat, A., Parks, V., Rolan, P., & Troy, S. (2001). Lack of pharmacokinetic interaction between retigabine and phenobarbital at steady-state in healthy subjects. Clinical Pharmacology and Therapeutics, 69(2), P48.
Scopus2
2000 Pace, S., Longo, A., Toon, S., Rolan, P., & Evans, A. M. (2000). Pharmacokinetics of propionyl- l-carnitine in humans: evidence for saturable tubular reabsorption. British journal of clinical pharmacology, 50(5), 441-448.
DOI Scopus30 WoS25 Europe PMC15
2000 Jacobsen, L. V., Rolan, P., Christensen, M. S., Knudsen, K. M., & Rasmussen, M. H. (2000). Bioequivalence between ready-to-use recombinant human growth hormone (rhGH) in liquid formulation and rhGH for reconstitution. Growth Hormone and IGF Research, 10(2), 93-98.
DOI Scopus19 Europe PMC11
2000 Palmer, J. E., Chronicle, E. P., Rolan, P., & Mulleners, W. M. (2000). Cortical hyperexcitability is cortical under-inhibition: Evidence from a novel functional test of migraine patients. Cephalalgia, 20(6), 525-532.
DOI Scopus118 Europe PMC92
2000 Møller, S. E., Larsen, F., Pitsiu, M., & Rolan, P. E. (2000). Effect of citalopram on plasma levels of oral theophylline. Clinical Therapeutics, 22(12), 1494-1501.
DOI Scopus14
1999 Heinig, R., Kitchin, N., & Rolan, P. (1999). Disposition of a single dose of warfarin in healthy individuals after pretreatment with metrifonate. Clinical Drug Investigation, 18(2), 151-159.
DOI Scopus2
1999 Yeh, K. C., Stone, J. A., Carides, A. D., Rolan, P., Woolf, E., & Ju, W. D. (1999). Simultaneous investigation of indinavir nonlinear pharmacokinetics and bioavailability in healthy volunteers using stable isotope labeling technique: Study design and model-independent data analysis. Journal of Pharmaceutical Sciences, 88(5), 568-573.
DOI Scopus35 Europe PMC20
1998 Peck, R. W., Seaber, E. J., Dixon, R. M., Layton, G. R., Weatherley, B. C., Jackson, S. H. D., . . . Posner, J. (1998). The pharmacodynamics and pharmacokinetics of the 5HT(1B/1D)-agonist zolmitriptan in healthy young and elderly men and women. Clinical Pharmacology and Therapeutics, 63(3), 342-353.
DOI Scopus41 Europe PMC23
1998 Mercer, A. J., Lamb, R. J., Rolan, P. E., Gibbens, M., & Posner, J. (1998). Lack of an effect of zolmitriptan (Zomig, 311C90) on psychometric task performance: Results of a placebo-controlled study in healthy volunteers. Psychopharmacology, 140(4), 398-404.
DOI Scopus9 Europe PMC6
1998 Van, F., Rolan, P. E., Brennan, N., & Gennery, B. (1998). Differential effects of levo- and racemic bupivacaine on the eec in volunteers. Regional Anesthesia and Pain Medicine, 23(3 SUPPL.), 48.
DOI Scopus15
1997 Seaber, E., On, N., Dixon, R. M., Gibbens, M., Leavens, W. J., Liptrot, J., . . . Peck, R. W. (1997). The absolute bioavailability and metabolic disposition of the novel antimigraine compound zolmitriptan (311C90). British Journal of Clinical Pharmacology, 43(6), 579-587.
DOI Scopus61 Europe PMC40
1997 Lefèvre, G., Duval, M., Gauron, S., Brookman, L. J., Rolan, P. E., Morris, T. M., . . . Close, P. (1997). Effect of renal impairment on the pharmacokinetics and pharmacodynamics of desirudin. Clinical Pharmacology and Therapeutics, 62(1), 50-59.
DOI Scopus58 Europe PMC29
1997 Brookman, L. J., Rolan, P. E., Benjamin, I. S., Palmer, K. R., Wyld, P. J., Lloyd, P., . . . Mullins, F. (1997). Pharmacokinetics of valsartan in patients with liver disease. Clinical Pharmacology and Therapeutics, 62(3), 272-278.
DOI Scopus98 Europe PMC65
1997 Wootton, R., Soul-Lawton, J., Rolan, P. E., Fook Sheung, C. T. C., Cooper, J. D. H., & Posner, J. (1997). Comparison of the pharmacokinetics of lamotrigine in patients with chronic renal failure and healthy volunteers. British Journal of Clinical Pharmacology, 43(1), 23-27.
DOI Scopus69 Europe PMC38
1997 Dixon, R. M., Meire, H. B., Evans, D. H., Watt, H., On, N., Posner, J., & Rolan, P. E. (1997). Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunteers. Cephalalgia, 17(6), 639-646.
DOI Scopus24 Europe PMC20
1997 Seaber, E., On, N., Dixon, R. M., Gibbnes, M., Leavens, W. J., Liptrot, J., . . . Peck, R. W. (1997). The absolute bioavailability and metabolic disposition of the novel antimigraine compound zolmitriptan (311 C90). International Journal of Clinical Pharmacology and Therapeutics, 35(9), 398.
Scopus1
1997 Higginbotham, F., & Rolan, P. (1997). Clinical pharmacology studies in women of child-bearing potential. International Journal of Pharmaceutical Medicine, 11(1), 7-9.
1997 Priskorn, M., Sidhu, J. S., Larsen, F., Davis, J. D., Khan, A. Z., & Rolan, P. E. (1997). Investigation of multiple dose citalopram on the pharmacokinetics and pharmacodynamics of racemic warfarin. British Journal of Clinical Pharmacology, 44(2), 199-202.
DOI Scopus50 Europe PMC34
1997 Rolan, P. (1997). Potential drug interactions with the novel antimigraine compound zolmitriptan (Zomig™, 311C90). Cephalalgia, 17(18_suppl), 21-27.
DOI Scopus60 Europe PMC38
1997 Rolan, P. (1997). The contribution of clinical pharmacology surrogates and models to drug development - A critical appraisal. British Journal of Clinical Pharmacology, 44(3), 219-225.
DOI Scopus93 Europe PMC49
1997 Rolan, P. E., Mercer, A. J., Tate, E., Benjamin, I., & Posner, J. (1997). Disposition of atovaquone in humans. Antimicrobial Agents and Chemotherapy, 41(6), 1319-1321.
DOI Scopus40 Europe PMC28
1996 Davis, J. D., Dixon, R., Khan, A. Z., Toon, S., Rolan, P. E., & Posner, J. (1996). Atovaquone has no effect on the pharmacokinetics of phenytoin in healthy male volunteers. British Journal of Clinical Pharmacology, 42(2), 246-248.
DOI Scopus8 Europe PMC2
1996 Dixon, R., Pozniak, A. L., Watt, H. M., Rolan, P., & Posner, J. (1996). Single-dose and steady-state pharmacokinetics of a novel microfluidized suspension of atovaquone in human immunodeficiency virus-seropositive patients. Antimicrobial Agents and Chemotherapy, 40(3), 556-560.
DOI Scopus30 Europe PMC23
1996 Seaber, E., On, N., Phillips, S., Churchus, R., Posner, J., & Rolan, P. (1996). The tolerability and pharmacokinetics of the novel antimigraine compound 311C90 in healthy male volunteers. British Journal of Clinical Pharmacology, 41(2), 141-147.
DOI Scopus72 Europe PMC37
1996 Dixon, R. M., Meire, H. B., Leigh, C., Posner, J., & Rolan, P. E. (1996). Evaluation of non-invasive techniques to assess vasoconstriction in healthy volunteers using methoxamine as a probe drug. Cephalalgia, 16(7), 507-517.
DOI Scopus2 Europe PMC2
1996 Arya, R., Rolan, P. E., Wootton, R., Posner, J., & Bellingham, A. J. (1996). Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia. British Journal of Haematology, 93(4), 817-821.
DOI Scopus49 Europe PMC36
1996 Rolan, P. E., Benjamin, I., Brookman, L., Sioufi, A., & Mullins, F. (1996). A model for quantitative estimation of biliary drug excretion in man. British Journal of Clinical Pharmacology, 41(5), 460.
1995 Rolan, P., Mercer, A., Wootton, R., & Posner, J. (1995). Pharmacokinetics and pharmacodynamics of tucaresol, an antisickling agent, in healthy volunteers.. British Journal of Clinical Pharmacology, 39(4), 375-380.
DOI Scopus28 Europe PMC24
1995 Rolan, P. (1995). Pharmacokinetics of New Antiherpetic Agents. Clinical Pharmacokinetics, 29(5), 333-340.
DOI Scopus28 Europe PMC11
1995 Soul-Lawton, J., Seaber, E., On, N., Wootton, R., Rolan, P., & Posner, J. (1995). Absolute bioavailability and metabolic disposition of valaciclovir, the L- valyl ester of acyclovir, following oral administration to humans. Antimicrobial Agents and Chemotherapy, 39(12), 2759-2764.
DOI Scopus305 Europe PMC192
1994 Rolan, P. (1994). Plasma protein binding displacement interactions—why are they still regarded as clinically important?. British Journal of Clinical Pharmacology, 37(2), 125-128.
DOI Scopus279 Europe PMC155
1994 Rolan, P., Mercer, A., Weatherley, B., Holdich, T., Meire, H., Peck, R., . . . Posner, J. (1994). Examination of some factors responsible for a food‐induced increase in absorption of atovaquone.. British Journal of Clinical Pharmacology, 37(1), 13-20.
DOI Scopus124 Europe PMC77
1993 Rolan, P., Parker, J., Gray, S., Weatherley, B., Ingram, J., Leavens, W., . . . Posner, J. (1993). The pharmacokinetics, tolerability and pharmacodynamics of tucaresol (589C80; 4[2‐formyl‐3‐hydroxyphenoxymethyl] benzoic acid), a potential anti‐sickling agent, following oral administration to healthy subjects.. British Journal of Clinical Pharmacology, 35(4), 419-425.
DOI Scopus31 Europe PMC21
1992 Phillips, S. C., Rolan, P. E., Posner, J., Halpern, S., Wijayawardhana, P., & Crome, P. (1992). Greater ease of swallowing of a new film-coated 800-mg dispersible acyclovir (Zovirax®) tablet compared to the standard 800-mg tablet in elderly volunteers. Journal of Pharmaceutical Medicine, 2(4), 259-262.
Scopus4
1990 Rolan, P. E., Phillips, S., Adams, J., & Posner, J. (1990). The onset of effect of the H1-antagonist acrivastine ("Semprex") assessed by histamine bronchial challenge in volunteers. European Journal of Clinical Pharmacology, 39(3), 311-313.
DOI Scopus5 Europe PMC3
1989 Rolan, P. E., Adams, J., & Posner, J. (1989). Comparison of the onset of H1-antagonism with acrivastine and terfenadine by histamine bronchial challenge in volunteers. Journal of International Medical Research, 17(SUPPL. 2), 35B-39B.
Scopus8 Europe PMC5
1987 Somogyi, A., Stockley, C., Keal, J., Rolan, P., & Bochner, F. (1987). Reduction of metformin renal tubular secretion by cimetidine in man.. British Journal of Clinical Pharmacology, 23(5), 545-551.
DOI Scopus278 WoS237 Europe PMC186
1987 Bochner, F., Graham, G. G., Polverino, A., Imhoff, D. M., Tregenza, R. A., Rolan, P. E., & Cleland, L. G. (1987). Salicyl phenolic glucuronide pharmacokinetics in patients with rheumatoid arthritis. European Journal of Clinical Pharmacology, 32(2), 153-158.
DOI Scopus12 WoS11 Europe PMC10
1987 Somogyi, A. A., Bochner, F., Keal, J. A., Rolan, P. E., & Smith, M. (1987). Effect of food on enoxacin absorption. Antimicrobial Agents and Chemotherapy, 31(4), 638-639.
DOI Scopus25 WoS30 Europe PMC26
1986 Muirhead, M. K., somogyi, A. A., Rolan, P. E., & Bochner, F. (1986). Effect of cimetidine on renal and hepatic drug elimination: Studies with triamterene. Clinical Pharmacology and Therapeutics, 40(4), 400-407.
DOI Scopus44 WoS54 Europe PMC30
1986 Somogyi, A., & Rolan, P. (1986). Drug disposition and dosing in hepatic disease. Medical Journal of Australia, 145(6), 284-289.
DOI Scopus1 WoS2 Europe PMC1
1986 Rolan, P., & Somogyi, A. (1986). Prescribing for the patient with renal disease. Medical Journal of Australia, 145(5), 210-215.
DOI WoS1
1986 Stockley, C., Keal, J., Rolan, P., Bochner, F., & Somogyi, A. (1986). Lack of inhibition of tolbutamide hydroxylation by cimetidine in man. European Journal of Clinical Pharmacology, 31(2), 235-237.
DOI Scopus16 WoS17 Europe PMC10
1986 Rolan, P. E., Muirhead, M., & Clarkson, A. R. (1986). Increased plasma levels of alpha-1-acid glycoprotein in chronic renal failure are unlikely to be due to decreased renal elimination.. Nephron, 42(4), 345-346.
DOI Scopus2 WoS6 Europe PMC3
1983 Rolan, P. E., Frewin, D. B., & Hagley, S. R. (1983). Anomalous serum concentrations of digoxin.. Annals of Internal Medicine, 99(2), 280-281.
DOI Scopus1 WoS1 Europe PMC1
1983 Rolan, P. E., Somogyi, A. A., Drew, M. J. R., Cobain, W. G., South, D., & Bochner, F. (1983). Phenytoin intoxication during treatment with parenteral miconazole. British Medical Journal, 287(6407), 1760.
DOI Scopus26 WoS24 Europe PMC18

Year Citation
2013 Rolan, P., & Molnár, V. (2013). Clinical Pharmacokinetics. In Textbook of Pharmaceutical Medicine (pp. 113-131). Wiley.
DOI Scopus1
2012 Woodcock, J., Atkinson, A. J., & Rolan, P. (2012). Physiological and Laboratory Markers of Drug Effect. In Principles of Clinical Pharmacology Third Edition (pp. 309-325). Elsevier.
DOI Scopus3
2009 Rolan, P., & Molnár, V. (2009). Clinical Pharmacokinetics. In Textbook of Pharmaceutical Medicine 6th Edition (pp. 167-184). Wiley.
DOI Scopus1
2007 Cope, R., & Rolan, P. (2007). Phase I Healthy Volunteers Studies. In Good Clinical Laboratory and Manufacturing Practices Techniques for the Qa Professional (pp. 137-146). Royal Society of Chemistry.
DOI
2007 Rolan, P. (2007). Physiological and laboratory makers of drug effect. In Principles of Clinical Pharmacology (2 ed., pp. 275-283). San Diego: Academic Press.
DOI
2006 Rolan, P. (2006). Clinical Pharmacokintetics. In The Textbook of Pharmaceutical Medicine (5 ed., pp. 176-197). Malden, Mass: Blackwell Publishers Inc.
2006 Tfelt-Hansen, P., & Rolan, P. (2006). β adrenoceptor blocking drugs in migraine prophylaxis. In The headaches (3rd ed., pp. 519-528). Philadelphia, Pa. ; London: Lippincott Williams & Wilkins.
2006 Dahlof, C., Rolan, P., & Tfelt-Hansen, P. (2006). Principles of clinical pharmacology, randomized controlled clinical trials, and evidence-based medicine in headache. In The headaches (3rd ed., pp. 55-62). Lippincott Williams & Wilkins.
2006 Tfelt-Hansen, P., & Rolan, P. (2006). Nonsteroidal anti-inflammatory drugs in the acute treatment of migraines. In J. Oelsen, P. Goadsby, N. Ramadam, P. Tfelt-Hansen, & K. Welch (Eds.), The headaches (3 ed., pp. 449-458). Philadelphia: Lippincott Williams & Wilkins.
2006 Rolan, P., & Molnar, V. (2006). The assessment of pharmacokinetics in early phase drug evaluation. In Clinical Trials of Drugs and Biopharmaceuticals (pp. 123-132). USA: Taylor & Francis.
DOI
2006 Atkinson, A. J., & Rolan, P. (2006). Physiological and Laboratory Markers of Drug Effect. In Principles of Clinical Pharmacology (pp. 275-287).
DOI

Year Citation
2003 Rolan, P., Atkinson, A. J., & Lesko, L. J. (2003). Use of biomarkers from drug discovery through clinical practice: Report of the Ninth European Federation of Pharmaceutical Sciences Conference on Optimizing Drug Development. In Clinical Pharmacology and Therapeutics Vol. 73 (pp. 284-291). United States: Wiley.
DOI Scopus80 Europe PMC50
1993 Rolan, P. E., Maillot, F., On, N. T., & Posner, J. (1993). The effects of cimetidine and probenecid on the conversion of a valine ester of acyclovir, 256U, to acyclovir and acyclovir renal clearance in healthy volunteers. In British Journal of Clinical Pharmacology Vol. 35 (pp. 533).
Scopus8
1990 Gray, S. J., Rolan, P., & Posner, J. (1990). Effect of intravenous 443C81 on cold air-induced bronchoconstriction in healthy volunteers. In European Journal of Pharmacology Vol. 183 (pp. 1045). Elsevier BV.
DOI

Year Citation
2020 Rolan, P., Dodds, K., Lees, F., Staikopoulos, V., Gosnell, M., Goldys, E., & Hutchinson, M. (2020). TWO NOVEL BIOMARKERS FOR MIGRAINE IN PERIPHERAL BLOOD MONONUCLEAR CELLS. Poster session presented at the meeting of CEPHALALGIA. ELECTR NETWORK: SAGE PUBLICATIONS LTD.
2014 Hillock, N. T., Gailer, J., Rolan, P., & Hill, C. (2014). South Australian Medicines Evaluation Panel: Evolution from inception to now (poster presentation). Poster session presented at the meeting of National Medicines Symposium. Brisbane.
2013 Hillock, N. T., Ward, M., Rolan, P., & Hill, C. (2013). A statewide evaluation process for high cost medicines: The challenges of a poor evidence base (poster presentation). Poster session presented at the meeting of Medicines Management (SHPA) Conference. Cairns.
2013 Rolan, P. E., Hutchinson, M. R., Buijs, M., Tuke, J., Kwok, Y. H., Gentgall, M., . . . Nillsen, N. (2013). First demonstration of the neuroimmune link in humans using IV Endotoxin and Intradermal Capsaicin in the face and arm. Poster session presented at the meeting of JOURNAL OF HEADACHE AND PAIN. SPRINGER-VERLAG ITALIA SRL.
DOI

Date Role Research Topic Program Degree Type Student Load Student Name
2022 - 2025 Co-Supervisor THE EFFECT OF EXERCISE ON CENTRAL SENSITISATION-RELATED
SYMPTOMS IN INDIVIDUALS WITH CHRONIC NECK PAIN		 Doctor of Philosophy Doctorate Full Time Mr Kexun Kenneth Chen
2017 - 2020 Principal Supervisor Improving Breast Health: The Use of Hormonal Combinations to Reduce Mammographic Breast Density and the Utility of Shear Wave Elastography as a Biomarker of the Effects of these Interventions Doctor of Philosophy Doctorate Part Time Ms Daniella Dougherty
2014 - 2017 Co-Supervisor Renal Denervation: A Therapeutic Option for Resistant Hypertension Doctor of Philosophy Doctorate Full Time Dr Sinny Delacroix
2013 - 2021 Principal Supervisor Investigations into the Lived Experience and Aetiology of Dysmenorrhoea and Pelvic Pain in Young Women Doctor of Philosophy Doctorate Part Time APrf Susan Evans
2010 - 2013 Principal Supervisor Neuro-endocrine Function in Older Men with Chronic Pain - Effects of Chronic Opioid Usage Master of Medical Science Master Part Time Ms Clare Haylock
2010 - 2015 Principal Supervisor The thermal grill as a tool to investigate analgesic clinical pharmacology Doctor of Philosophy Doctorate Full Time Mrs Nicole Martha Sumracki
2010 - 2014 Principal Supervisor A pilot study assessing fentanyl dose requirements in opioid-maintained individuals Master of Philosophy (Medical Science) Master Full Time Dr Muhammad Imran Ahmad
2010 - 2015 Co-Supervisor Sex Differences in Allodynia: A complex Interaction Between 17beta-Oestradiol and the Innate Immune System Doctor of Philosophy Doctorate Full Time Miss Lauren Louise Nicotra
2010 - 2015 Principal Supervisor Codeine, heightened pain sensitivity and medication overuse headache: A neuroimmune hypothesis and novel treatment strategy. Doctor of Philosophy Doctorate Full Time Miss Jacinta Lee Johnson
2009 - 2014 Principal Supervisor Potential peripheral biomarkers for chronic pain Doctor of Philosophy Doctorate Full Time Miss Yuen Kwok
2007 - 2011 Principal Supervisor Two methods of biomarker discovery: applications in neuropathic pain and pharmacotherapy Doctor of Philosophy Doctorate Full Time Mr Peter Grace

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