Paul Joyce

Teaching Strengths

Biomedical engineering
Pharmaceutical sciences
Colloid and interface science

Dr Paul Joyce

Senior Research Fellow

School of Pharmacy and Biomedical Sciences

College of Health

Available For Media Comment.

Dr Paul Joyce is Head of the Translational Nanomedicine & Biotherapeutics Group at the University of South Australia where his research focuses on harnessing drug delivery approaches for transforming therapeutic outcomes across a wide range of diseases, including cancer, mental health, and antimicrobial resistance. Working at the interface of materials science and drug development, Dr Joyce engages closely with key stakeholders who enable clinical and commercial translation of his research, including the pharmaceutical industry, clinicians, and health consumers. Dr Joyce’s leadership within this field is evidenced through his publication of over 70 peer reviewed papers in leading international journals, 3 book chapters, and 3 granted international patents for novel nanomedicine inventions. Further, Dr Joyce is a Director of the Australian Controlled Release Society, the leading society for delivery science, and has been awarded over $9M in funding to support his research activities, including serving as a current Hospital Research Foundation Fellow and Cancer Council SA Fellow.

Designing, engineering and applying innovative drug delivery solutions that overcome key biopharmaceutical challenges for the benefit of the wider community. Cutting edge biophysical and synthesis techniques are employed to develop novel strategies and technologies that are well-positioned for rapid clinical translation.

  • Drug delivery systems
  • Pharmaceutical formulation
  • Biomaterials
  • Biophysical analysis

Year Citation
2026 Chan, N. S. L., Cross, C., Prestidge, C. A., Wardill, H. R., Bowen, J., & Joyce, P. (2026). The resilient microbiome: how baseline gut microbial composition influences response to cancer treatment. Critical Reviews in Microbiology, 1-18.
DOI
2026 Khabir, Z., Abdelhafez, A., Camponovo, F., Joyce, P., & Garcia-Bennett, A. (2026). Role of the EPA: DHA dosing ratio in omega-3 supplements on blood fatty acid profiles and inflammation: a systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition, 1-22.
DOI
2026 Ariaee, A., Noueihad, K., Hunter, A., Wignall, A., Wardill, H. R., Davies, M., . . . Joyce, P. (2026). Gut microbiota perturbation and systemic inflammation are associated with salcaprozate sodium (SNAC)-enabled oral semaglutide delivery.. J Control Release, 392, 114711.
DOI Scopus2 WoS3
2026 Kamath, S., Chan, N. S. L., & Joyce, P. (2026). GLP-1 agonists and the gut microbiome: A bidirectional relationship. British Journal of Clinical Pharmacology, 92(5), 1309-1325.
DOI Scopus9 WoS9 Europe PMC3
2026 Asif, Z., Prestidge, C. A., & Joyce, P. (2026). Exploring the Impact of Lipid Structure and Composition on the Digestion of Next-Generation Meat and Dairy Analogues. Foods, 15(4), 772-1-772-16.
DOI Scopus1
2026 Hegishte, Y., Joyce, P., Prestidge, C., & Bremmell, K. (2026). Overcoming the oral delivery challenges of venetoclax: advancing a clinically improved Bcl-2 inhibitor. Drug Delivery and Translational Research, 21 pages.
DOI
2026 Wade, S. J., Kumar, A. A., Nitschke, S. O., Joyce, P., Minaei, E., Reuter Lange, S. E., . . . Vine-perrow, K. L. (2026). Efficacy and Safety Assessment of 5-Fluorouracil, Irinotecan and Oxaliplatin-Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy. Advanced Materials, 38(26), e22617-1-e22617-21.
DOI
2026 Abdelhafez, A., Khabir, Z., Garcia-Bennett, A., Prestidge, C. A., Camponovo, F. F., & Joyce, P. (2026). Omega-3 PUFA concentration and emulsification govern lipid digestion, micellar vesicle formation, and oral bioavailability of fish oil concentrates. Food Bioscience, 79, 108574-1-108574-13.
DOI
2026 Ariaee, A., Hunter, A., Wignall, A., Bremmell, K., Prestidge, C., & Joyce, P. (2026). Spray dried inulin–montmorillonite hybrids alleviate high-fat diet–induced inflammatory and metabolic dysregulation in rats. Biomaterials Advances, 185, 10 pages.
DOI
2026 Kamath, S., Sun, Y. -H., Wardill, H. R., & Joyce, P. (2026). Gut-brain axis targeting postbiotics for treatment of psychological and neurodegenerative disorders. Food Bioscience, 80, 108950.
DOI
2026 Ariaee, A., Wardill, H. R., Hunter, A., Wignall, A., Elz, A. S., Page, A. J., . . . Joyce, P. (2026). Konjac Glucomannan–Montmorillonite Hybrids as a Gut-Targeted Therapy for Addressing Diet-Induced Obesity in Mice. Nutrients, 18(8), 1298-1-1298-27.
DOI
2026 Collins, K., Donnellan, L., Asif, Z., Chan, N. S. L., Subramaniam, S., Kamath, S., . . . Joyce, P. (2026). The gut microbiome modulates the lipase-mediated digestion of dietary lipid emulsions. Colloids and Surfaces B: Biointerfaces, 265, 115715-1-115715-14.
DOI Scopus1 WoS1
2026 Khetan, R., Donnellan, L., Collins, K., Kamath, S., Ariaee, A., Rajapaksha, W., . . . Joyce, P. (2026). The gut microbiota regulates the protein corona formation, biodistribution, and cellular uptake of lipid nanoparticles.. Journal of controlled release : official journal of the Controlled Release Society, 395, 114995.
DOI
2025 Kamath, S., & Joyce, P. (2025). A critical need for 'gut neutrality': mitigating adverse drug-microbiome interactions. Expert Opinion on Drug Metabolism and Toxicology, 21(1), 1-4.
DOI Scopus14 WoS13 Europe PMC5
2025 Kamath, S., Ariaee, A., Abdelhafez, A., Asif, Z., Chan, N. S. L., Collins, K., . . . Joyce, P. (2025). Microbiome-active drug delivery systems (MADDS): leveraging microbial stimuli for controlled drug release. Advanced Drug Delivery Reviews, 227(115720), 1-23.
DOI Scopus10 WoS9 Europe PMC6
2025 Abdelhafez, A., Khabir, Z., Prestidge, C. A., Garcia Bennett, A., & Joyce, P. (2025). Impact of formulation design on the oral bioavailability of omega-3 polyunsaturated fatty acids. Food Research International, 208(116171), 1-16.
DOI Scopus8 WoS8 Europe PMC4
2025 Minaei, E., Joyce, P., Wade, S. J., Brownlee, C., Penney, C., Ranson, M., . . . Vine Perrow, K. L. (2025). Gut microbial diversity is preserved through localised chemo-immunotherapy delivery in a KPC mouse model of pancreatic cancer. Journal Of Controlled Release, 386(114143), 1-11.
DOI Scopus4 WoS5 Europe PMC2
2025 Kamath, S., Sokolenko, E., Collins, K., Chan, N. S. L., Mills, N., Clark, S. R., . . . Joyce, P. (2025). IUPHAR Themed Review: The Gut Microbiome in Schizophrenia.. Pharmacological Research, 211(107561), 107561-1-107561-13.
DOI Scopus19 WoS17 Europe PMC14
2025 Wright, L., Wignall, A., Subramaniam, S., Schultz, H. B., Joyce, P., & Prestidge, C. A. (2025). Enhanced oral absorption and biodistribution to submandibular salivary glands of D-limonene in Sprague Dawley rats via a liquid-lipid formulation approach. International Journal of Pharmaceutics, 670(125179), 125179.
DOI Scopus1 WoS1 Europe PMC1
2025 Kamath, S., Bryant, R. V., Costello, S. P., Day, A. S., Forbes, B., Haifer, C., . . . Joyce, P. (2025). Translational strategies for oral delivery of faecal microbiota transplantation.. Gut, online(12), gutjnl-2025-335077.
DOI Scopus15 WoS15 Europe PMC10
2025 Kamath, S., Sokolenko, E., Clark, S. R., Cross, C. B., Scott, J., Wardill, H. R., . . . Joyce, P. (2025). Distinguishing the causative, correlative and bidirectional roles of the gut microbiota in mental health. nature mental health, 3(10), 1137-1151.
DOI Scopus9 WoS10
2025 Subramaniam, S., Donnellan, L., Wignall, A., Woodcock, J., Coolen, C., Pitson, S., . . . Joyce, P. (2025). Polymeric-lipid nanoparticles that leverage cationic helper lipids and the protein corona for lung-targeted delivery of a novel anti-cancer drug. Journal of Controlled Release, 388(Pt 1), 114299.
DOI Scopus4 WoS5 Europe PMC1
2025 Taheri, A., Almasri, R., Wignall, A., Feltrin, F., Bremmell, K. E., Joyce, P., & Prestidge, C. A. (2025). Enteric coating enhances the Biopharmaceutical performance of a silica-lipid formulation of Abiraterone Acetate. Pharmaceutics, 17(10, article no. 1289), 1-12.
DOI
2024 Taheri, A., Almasri, R., Wignall, A., Schultz, H. B., Elz, A. S., Ariaee, A., . . . Prestidge, C. A. (2024). Enhancing the pharmacokinetics of abiraterone acetate through lipid-based formulations: addressing solubility and food effect challenges. Drug Delivery and Translational Research, online(11), 3770-3782.
DOI Scopus4 WoS5 Europe PMC2
2024 Meola, T. R., Kamath, S., Elz, A. S., Prestidge, C. A., Wignall, A., & Joyce, P. (2024). Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic. European Journal of Pharmaceutics and Biopharmaceutics, 203, 10 pages.
DOI Scopus5 WoS4 Europe PMC3
2024 Kamath, S., Hunter, A., Collins, K., Wignall, A., & Joyce, P. (2024). The atypical antipsychotics lurasidone and olanzapine exert contrasting effects on the gut microbiome and metabolic function of rats. British Journal of Pharmacology, 181(22), 4531-4545.
DOI Scopus19 WoS19 Europe PMC17
2024 Meola, T. R., Elz, A., Wignall, A., Paxton, K., Hunter, A., Ariaee, A., . . . Joyce, P. (2024). Inulin-Lipid Core–Shell Microcapsules Target the Gut Microbiota and Mimic the Pharmaceutical Food Effect for Improved Oral Antipsychotic Delivery. Advanced Functional Materials, 34(40), 12 pages.
DOI Scopus22 WoS20
2024 Ariaee, A., Wardill, H. R., Wignall, A., Elz, A. S., Wright, L., Prestidge, C., & Joyce, P. (2024). Therapeutic Potential of Inulin-Coated MCT Microcapsules in Modulating the Gut Microbiome for Effective Treatment of Diet-Induced Obesity. Advanced Therapeutics, 8(3), 13 pages.
DOI Scopus3 WoS3
2024 Joyce, P., Allen, C. J., Alonso, M. J., Ashford, M., Bradbury, M. S., Germain, M., . . . Santos, H. A. (2024). A translational framework to DELIVER nanomedicines to the clinic. Nature Nanotechnology, 19(11), 1597-1611.
DOI Scopus200 WoS139 Europe PMC124
2024 Brewer, K., Wignall, A., Bazeed, A., Gundsambuu, B., Kohlhagen, J., Yan, J., . . . Blencowe, A. (2024). Customizable and Open-Source 3D Printed Inserts for Controlled Release and Cell Culture Experiments. ACS Applied Polymer Materials, 6(19), 11813-11827.
DOI
2024 Ariaee, A., Koentgen, S., Wardill, H. R., Hold, G. L., Prestidge, C. A., Armstrong, H. K., & Joyce, P. (2024). Prebiotic selection influencing inflammatory bowel disease treatment outcomes: A review of the preclinical and clinical evidence. eGastroenterology, 2(2), 1-14.
DOI Scopus20 WoS19 Europe PMC7
2024 Ariaee, A., Wardill, H. R., Wignall, A., Prestidge, C. A., & Joyce, P. (2024). Correction: Ariaee et al. The Degree of Inulin Polymerization Is Important for Short-Term Amelioration of High-Fat Diet (HFD)-Induced Metabolic Dysfunction and Gut Microbiota Dysbiosis in Rats. Foods 2024, 13, 1039. Foods, 13(24), 4030.
DOI
2024 Subramaniam, S., Joyce, P., Ogunniyi, A. D., Dube, A., Sampson, S. L., Lehr, C. M., & Prestidge, C. A. (2024). Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays. ACS Infectious Diseases, 10(2), 337-349.
DOI Scopus8 WoS7 Europe PMC7
2024 Nguyen, T. M., Joyce, P., Ross, D. M., Bremmell, K., Jambhrunkar, M., Wong, S. S., & Prestidge, C. A. (2024). Combating Acute Myeloid Leukemia via Sphingosine Kinase 1 Inhibitor-Nanomedicine Combination Therapy with Cytarabine or Venetoclax. Pharmaceutics, 16(2), 209-1-209-16.
DOI Scopus8 WoS6 Europe PMC3
2024 Revesz, I. A., Joyce, P., Ebert, L. M., & Prestidge, C. A. (2024). Effective γδ T-cell clinical therapies: current limitations and future perspectives for cancer immunotherapy. Clinical and Translational Immunology, 13(2, article no. e1492), 1-16.
DOI Scopus17 WoS15 Europe PMC9
2024 Ariaee, A., Wardill, H. R., Wignall, A., Prestidge, C. A., & Joyce, P. (2024). The Degree of Inulin Polymerization Is Important for Short-Term Amelioration of High-Fat Diet (HFD)-Induced Metabolic Dysfunction and Gut Microbiota Dysbiosis in Rats. Foods, 13(7), 1039.
DOI Scopus20 WoS18 Europe PMC9
2024 Stringer, A. M., Hargreaves, B. M., Mendes, R. A., Blijlevens, N. M. A., Bruno, J. S., Joyce, P., . . . Wardill, H. R. (2024). Updated perspectives on the contribution of the microbiome to the pathogenesis of mucositis using the MASCC/ISOO framework. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 32(8), 558-1-558-15.
DOI Scopus17 WoS16 Europe PMC11
2024 Cross, C., Davies, M., Bateman, E., Crame, E., Joyce, P., Wignall, A., . . . Bowen, J. (2024). Fibre-rich diet attenuates chemotherapy-related neuroinflammation in mice. Brain, Behavior, and Immunity, 115, 13-25.
DOI Scopus20 WoS19 Europe PMC11
2024 Subramaniam, S., Joyce, P., & Prestidge, C. A. (2024). The biomolecule corona mediates pulmonary delivery of nanomedicine. European Journal of Pharmaceutics and Biopharmaceutics, 202(114420), 1-8.
DOI Scopus5 WoS5 Europe PMC4
2024 Ahsan, A., Thomas, N., Barnes, T. J., Subramaniam, S., Loh, T. C., Joyce, P., & Prestidge, C. A. (2024). Lipid nanocarriers-enabled delivery of antibiotics and antimicrobial adjuvants to overcome bacterial biofilms. Pharmaceutics, 16(3, article no. 396), 1-46.
DOI Scopus69 WoS60 Europe PMC34
2024 Subramaniam, S., Joyce, P., Conn, C. E., & Prestidge, C. A. (2024). Cellular uptake and in vitro antibacterial activity of lipid-based nanoantibiotics are influenced by protein corona. Biomaterials Science, 12(13), 3411-3422.
DOI Scopus10 WoS9 Europe PMC8
2024 Iscaro, J., Yu, H., Martinez, N., Subramaniam, S., Joyce, P., Wang, H., . . . Zhai, J. (2024). Lyotropic liquid crystalline phase nanostructure and cholesterol enhance lipid nanoparticle mediated mRNA transfection in macrophages. Advanced Functional Materials, 34(no. 46, article no. 2405286), 1-15.
DOI Scopus17 WoS18
2024 Ariaee, A., Salim, M., Boyd, B. J., Prestidge, C., & Joyce, P. (2024). Montmorillonite restricts free fatty acid liberation and alters self-assembled structures formed during in vitro lipid digestion. Journal of Colloid and Interface Science, 675, 660-669.
DOI Scopus5 WoS5 Europe PMC1
2024 Kerstens, R., & Joyce, P. (2024). The gut microbiome as a catalyst and emerging therapeutic target for Parkinson's Disease: a comprehensive update. Biomedicines, 12(8, article no. 1738), 1-35.
DOI Scopus10 WoS9 Europe PMC7
2023 Subramaniam, S., Elz, A., Wignall, A., Kamath, S., Ariaee, A., Hunter, A., . . . Joyce, P. (2023). Self-emulsifying drug delivery systems (SEDDS) disrupt the gut microbiota and trigger an intestinal inflammatory response in rats. International Journal of Pharmaceutics, 648(123614), 123614-1-123614-10.
DOI Scopus41 WoS34 Europe PMC23
2023 Møller, A., Schultz, H. B., Meola, T. R., Joyce, P., Müllertz, A., & Prestidge, C. A. (2023). The Influence of Blonanserin Supersaturation in Liquid and Silica Stabilised Self-Nanoemulsifying Drug Delivery Systems on In Vitro Solubilisation. Pharmaceutics, 15(1), 14 pages.
DOI Scopus1
2023 Maghrebi, S., Thomas, N., Prestidge, C. A., & Joyce, P. (2023). Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages. Drug Delivery and Translational Research, 13(6), 1716-1729.
DOI Scopus20 WoS17 Europe PMC10
2023 Subramaniam, S., Joyce, P., & Prestidge, C. A. (2023). Liquid crystalline lipid nanoparticles improve the antibacterial activity of tobramycin and vancomycin against intracellular Pseudomonas aeruginosa and Staphylococcus aureus. International Journal of Pharmaceutics, 639(639, article no. 122927), 1-9.
DOI Scopus16 WoS16 Europe PMC11
2023 Subramaniam, S., Kamath, S., Ariaee, A., Prestidge, C., & Joyce, P. (2023). The impact of common pharmaceutical excipients on the gut microbiota. Expert Opinion on Drug Delivery, 20(10), 1297-1394.
DOI Scopus33 WoS32 Europe PMC24
2023 Hassan, M. M., Romana, B., Mao, G., Kumar, N., Sonvico, F., Thordarson, P., . . . Prestidge, C. A. (2023). Liposome-Micelle-Hybrid (LMH) carriers for controlled co-delivery of 5-FU and paclitaxel as chemotherapeutics. Pharmaceutics, 15(7, article no. 1886), 1-17.
DOI Scopus17 WoS15 Europe PMC4
2023 Taheri, A., Bremmell, K. E., Joyce, P., & Prestidge, C. A. (2023). Battle of the milky way: lymphatic targeted drug delivery for pathogen eradication. Journal of Controlled Release, 363, 507-524.
DOI Scopus14 WoS10 Europe PMC8
2023 Awad, M., Kopecki, Z., Barnes, T. J., Wignall, A., Joyce, P., Thomas, N., & Prestidge, C. A. (2023). Lipid Liquid Crystal Nanoparticles: Promising Photosensitizer Carriers for the Treatment of Infected Cutaneous Wounds. Pharmaceutics, 15(2), 1-18.
DOI Scopus7 WoS6 Europe PMC3
2023 Wright, L., Wignall, A., Jõemetsa, S., Joyce, P., & Prestidge, C. A. (2023). A membrane-free microfluidic approach to mucus permeation for efficient differentiation of mucoadhesive and mucopermeating nanoparticulate systems. Drug Delivery and Translational Research, 13(4), 1088-1101.
DOI Scopus12 WoS13 Europe PMC10
2023 Nguyen, T. M., Jambhrunkar, M., Wong, S. S., Ross, D. M., Joyce, P., Finnie, J. W., . . . Prestidge, C. A. (2023). Targeting Acute Myeloid Leukemia Using Sphingosine Kinase 1 Inhibitor-Loaded Liposomes.. Molecular pharmaceutics, 20(8), 3937-3946.
DOI Scopus10 WoS8 Europe PMC6
2023 Kamath, S., Stringer, A. M., Prestidge, C. A., & Joyce, P. (2023). Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery. Expert Opinion on Drug Delivery, 20(10), 1315-1331.
DOI Scopus41 WoS35 Europe PMC30
2023 Subramaniam, S., Joyce, P., Donnellan, L., Young, C., Wignall, A., Hoffmann, P., & Prestidge, C. A. (2023). Protein adsorption determines pulmonary cell uptake of lipid-based nanoparticles. Journal of Colloid and Interface Science, 641, 36-47.
DOI Scopus39 WoS41 Europe PMC25
2022 Wright, L., Barnes, T. J., Joyce, P., & Prestidge, C. A. (2022). Optimisation of a High-Throughput Model for Mucus Permeation and Nanoparticle Discrimination Using Biosimilar Mucus. Pharmaceutics, 14(12), 2659.
DOI Scopus12 WoS11 Europe PMC5
2022 Joyce, P., Wignall, A., Peressin, K., Wright, L., Williams, D. B., & Prestidge, C. A. (2022). Chitosan nanoparticles facilitate improved intestinal permeation and oral pharmacokinetics of the mast cell stabiliser cromoglycate. International Journal of Pharmaceutics, 612(121382), 121382.
DOI Scopus17 WoS19 Europe PMC9
2022 Awad, M., Barnes, T. J., Thomas, N., Joyce, P., & Prestidge, C. A. (2022). Gallium Protoporphyrin Liquid Crystalline Lipid Nanoparticles: A Third-Generation Photosensitizer against Pseudomonas aeruginosa Biofilms. Pharmaceutics, 14(10), 2124.
DOI Scopus15 WoS16 Europe PMC8
2022 Awad, M., Barnes, T. J., Joyce, P., Thomas, N., & Prestidge, C. A. (2022). Liquid crystalline lipid nanoparticle promotes the photodynamic activity of gallium protoporphyrin against S. aureus biofilms. Journal of Photochemistry and Photobiology B: Biology, 232(112474), 112474.
DOI Scopus18 WoS17 Europe PMC9
2022 Almasri, R., Schultz, H. B., Møller, A., Bremmell, K. E., Garcia Bennett, A., Joyce, P., & Prestidge, C. A. (2022). Role of silica intrawall microporosity on abiraterone acetate solubilization and in vivo oral absorption. Molecular Pharmaceutics, 19(4), 1091-1103.
DOI Scopus6 WoS6 Europe PMC5
2022 Chen, J., Hanrahan, J. P., McGrath, J., Courtney, M. A., Prestidge, C. A., & Joyce, P. (2022). The anti-obesity effect of porous silica is dependent on pore nanostructure, particle size, and surface chemistry in an in vitro digestion model. Pharmaceutics, 14(9, article no. 1813), 1-16.
DOI
2022 Wang, W., Joyce, P., Bremmell, K., Milne, R., & Prestidge, C. A. (2022). Liposomal 5-fluorouracil polymer complexes facilitate tumor-specific delivery: pharmaco-distribution kinetics using microdialysis. Pharmaceutics, 14(2, article no. 221), 1-16.
DOI Scopus12 WoS10 Europe PMC8
2021 Joyce, P., Jõemetsa, S., Isaksson, S., Hossain, S., Larsson, P., Bergström, C., & Höök, F. (2021). TIRF Microscopy-Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica. Angewandte Chemie International Edition, 60(4), 2069-2073.
DOI Scopus16 Europe PMC12
2021 Subramaniam, S., Joyce, P., Thomas, N., & Prestidge, C. A. (2021). Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections. Advanced Drug Delivery Reviews, 177(113948), 1-23.
DOI Scopus87 WoS84 Europe PMC63
2021 Olsén, E., Jõemetsa, S., González, A., Joyce, P., Zhdanov, V. P., Midtvedt, D., & Höök, F. (2021). Diffusion of lipid nanovesicles bound to a lipid membrane is associated with the partial-slip boundary condition. Nano Letters, 21(19), 8503-8509.
DOI Scopus12 WoS12 Europe PMC8
2021 Hedge, O. J., Höök, F., Joyce, P., & Bergström, C. A. S. (2021). Investigation of self-emulsifying drug-delivery system interaction with a biomimetic membrane under conditions relevant to the small intestine. Langmuir, 37(33), 10200-10213.
DOI Scopus11 WoS10 Europe PMC5
2021 Wright, L., Joyce, P., Barnes, T. J., Lundmark, R., Bergström, C. A. S., Hubert, M., & Prestidge, C. A. (2021). A Comparison of Chitosan, Mesoporous Silica and Poly(lactic-co-glycolic) Acid Nanocarriers for Optimising Intestinal Uptake of Oral Protein Therapeutics. Journal of Pharmaceutical Sciences, 110(1), 217-227.
DOI Scopus12 WoS12 Europe PMC8
2021 Wright, L., Joyce, P., Barnes, T. J., & Prestidge, C. A. (2021). Mimicking the Gastrointestinal Mucus Barrier: Laboratory-Based Approaches to Facilitate an Enhanced Understanding of Mucus Permeation. ACS Biomaterials Science & Engineering, 9(6), 19 pages.
DOI Scopus27 WoS27 Europe PMC15
2021 Meola, T., Abuhelwa, A. Y., Joyce, P., Clifon, P., & Prestidge, C. (2021). A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants. Drug Delivery and Translational Research, 11(3), 1261-1272.
DOI Scopus37 WoS34 Europe PMC27
2021 Meola, T. R., Joyce, P., Wignall, A., Bremmell, K. E., & Prestidge, C. A. (2021). Harnessing the potential of nanostructured formulations to mimic the food effect of lurasidone. International Journal of Pharmaceutics, 608(121098), 10 pages.
DOI Scopus11 WoS11 Europe PMC8
2020 Joyce, P., Dening, T. J., Meola, T. R., Wignall, A., Ulmefors, H., Kovalainen, M., & Prestidge, C. A. (2020). Contrasting Anti-obesity Effects of Smectite Clays and Mesoporous Silica in Sprague-Dawley Rats. ACS Applied Bio Materials, 3(11), 7779-7788.
DOI Scopus16 WoS15 Europe PMC10
2020 Joyce, P., Ulmefors, H., Maghrebi, S., Subramaniam, S., Wignall, A., Jõemetsa, S., . . . Prestige, C. A. (2020). Enhancing the cellular uptake and antibacterial activity of rifampicin through encapsulation in mesoporous silica nanoparticles. Nanomaterials, 10(4), 1-16.
DOI Scopus40 WoS37 Europe PMC26
2020 Meola, T. R., Paxton, K., Joyce, P., Schultz, H. B., & Prestidge, C. A. (2020). The effect of drug ionization on lipid-based formulations for the oral delivery of anti-psychotics. Admet and Dmpk, 8(4), 437-451.
DOI Scopus10 WoS10 Europe PMC5
2020 Joyce, P., Meola, T. R., Schultz, H. B., & Prestidge, C. A. (2020). Biomaterials that regulate fat digestion for the treatment of obesity. Trends in Food Science and Technology, 100, 235-245.
DOI Scopus27 WoS23
2020 Maghrebi, S., Joyce, P., Jambhrunkar, M., Thomas, N., & Prestidge, C. A. (2020). Poly(lactic-co-glycolic) acid-lipid hybrid microparticles enhance the intracellular uptake and antibacterial activity of rifampicin. ACS, 12(7), 8030-8039.
DOI Scopus58 WoS54 Europe PMC41
2020 Schultz, H. B., Joyce, P., Thomas, N., & Prestidge, C. A. (2020). Supersaturated-silica lipid hybrids improve in vitro solubilization of abiraterone acetate. Pharmaceutical Research, 37(4, article number. 77), 1.
DOI Scopus19 WoS19 Europe PMC10
2020 Joyce, P., Ulmefors, H., Garcia Bennett, A., & Prestidge, C. A. (2020). Microporosity, pore size, and diffusional path length modulate lipolysis kinetics of triglycerides adsorbed onto SBA-15 mesoporous silica particles. Langmuir, 36(13), 3367-3376.
DOI Scopus8 WoS6 Europe PMC5
2020 Almasri, R., Joyce, P., Schultz, H. B., Thomas, N., Bremmell, K. E., & Prestidge, C. A. (2020). Porous nanostructure, lipid composition, and degree of drug supersaturation modulate in vitro fenofibrate solubilization in silica-lipid hybrids. Pharmaceutics, 12(7, article no. 687), 1-22.
DOI Scopus15 WoS15 Europe PMC11
2020 Maghrebi, S., Jambhrunkar, M., Joyce, P., & Prestidge, C. A. (2020). Engineering PLGA-lipid hybrid microparticles for enhanced macrophage uptake. ACS Applied Bio Materials, 3(7), 4159-4167.
DOI Scopus20 WoS18 Europe PMC11
2020 Hossain, S., Joyce, P., Parrow, A., Jõemetsa, S., Höök, F., Larsson, P., & Bergström, C. A. S. (2020). Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers. Molecular Pharmaceutics, 17(11), 4226-4240.
DOI Scopus44 Europe PMC34
2020 Jõemetsa, S., Joyce, P., Lubart, Q., Mapar, M., Celauro, E., Agnarsson, B., . . . Höök, F. (2020). Independent size and fluorescence emission determination of individual biological nanoparticles reveals that lipophilic dye incorporation does not scale with particle size. Langmuir, 36(33), 9693-9700.
DOI Scopus7 Europe PMC6
2019 Dening, T. J., Joyce, P., Kovalainen, M., Gustafsson, H., & Prestidge, C. A. (2019). Spray dried smectite clay particles as a novel treatment against obesity. Pharmaceutical research, 36(1, article no. 21), 1-14.
DOI Scopus26 WoS25 Europe PMC16
2019 Dening, T. J., Joyce, P., & Prestidge, C. A. (2019). Improving correlations between drug solubilization and in vitro lipolysis by monitoring the phase partitioning of lipolytic species for lipid-based formulations. Journal of pharmaceutical sciences, 108(1), 295-304.
DOI Scopus20 WoS20 Europe PMC11
2019 Joyce, P., Dening, T. J., Meola, T. R., Schultz, H. B., Holm, R., Thomas, N., & Prestidge, C. A. (2019). Solidification to improve the biopharmaceutical performance of SEDDS: opportunities and challenges. Advanced drug delivery reviews, 142, 102-117.
DOI Scopus113 WoS102 Europe PMC71
2019 Joyce, P., Dening, T. J., Meola, T. R., Gustafsson, H., Kovalainen, M., & Prestidge, C. A. (2019). Nanostructured clay particles supplement orlistat action in inhibiting lipid digestion: an in vitro evaluation for the treatment of obesity. European journal of pharmaceutical sciences, 135, 1-11.
DOI Scopus16 WoS15 Europe PMC8
2019 Maghrebi, S., Prestidge, C. A., & Joyce, P. (2019). An update on polymer-lipid hybrid systems for improving oral drug delivery. Expert opinion on drug delivery, 16(5), 507-524.
DOI Scopus45 WoS37 Europe PMC31
2019 Wang, L., Song, Y., Parikh, A., Joyce, P., Chung, R., Liu, L., . . . Garg, S. (2019). Doxorubicin-loaded delta inulin conjugates for controlled and targeted drug delivery: development, characterization, and in vitro evaluation. Pharmaceutics, 11(11), 581-1-581-17.
DOI Scopus34 WoS26 Europe PMC19
2018 Joyce, P., & Prestidge, C. A. (2018). Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the intestinal solubilisation of a lipophilic weak base. European journal of pharmaceutical sciences, 118, 40-48.
DOI Scopus24 WoS22 Europe PMC13
2018 Joyce, P., Gustafsson, H., & Prestidge, C. A. (2018). Enhancing the lipase-mediated bioaccessibility of omega-3 fatty acids by microencapsulation of fish oil droplets within porous silica particles. Journal of functional foods, 47, 491-502.
DOI Scopus31 WoS29
2018 Joyce, P., Gustafsson, H., & Prestidge, C. A. (2018). Engineering intelligent particle-lipid composites that control lipase-mediated digestion. Advances in colloid and interface science, 260, 1-23.
DOI Scopus24 WoS22 Europe PMC12
2018 Dening, T. J., Joyce, P., Webber, J. L., Beattie, D. A., & Prestidge, C. A. (2018). Inorganic surface chemistry and nanostructure controls lipolytic product speciation and partitioning during the digestion of inorganic-lipid hybrid particles. Journal of Colloid and Interface Science, 532, 666-679.
DOI Scopus26 WoS23 Europe PMC14
2017 Joyce, P., Yasmin, R., Bhatt, A., Boyd, B. J., Pham, A., & Prestidge, C. A. (2017). Comparison across three hybrid lipid-based drug delivery systems for improving the oral absorption of the poorly water-soluble weak base cinnarizine. Molecular pharmaceutics, 14(11), 4008-4018.
DOI Scopus23 WoS20 Europe PMC14
2017 Joyce, P., Dening, T. J., Gustafsson, H., & Prestidge, C. A. (2017). Modulating the lipase-mediated bioactivity of particle-lipid conjugates through changes in nanostructure and surface chemistry. European journal of lipid science and technology, 119(12, article no. 1700213), 1-9.
DOI Scopus13 WoS12
2017 Wang, L., Barclay, T., Song, Y., Joyce, P., Sakala, I. G., Petrovsky, N., & Garg, S. (2017). Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant. Vaccine, 35(34), 4382-4388.
DOI Scopus18 WoS19 Europe PMC14
2016 Joyce, P., Kempson, I., & Prestidge, C. A. (2016). Orientating lipase molecules through surface chemical control for enhanced activity: A QCM-D and ToF-SIMS investigation. Colloids and Surfaces B Biointerfaces, 142, 173-181.
DOI Scopus32 WoS30 Europe PMC16
2016 Joyce, P., Whitby, C. P., & Prestidge, C. A. (2016). Nanostructuring biomaterials with specific activities towards digestive enzymes for controlled gastrointestinal absorption of lipophilic bioactive molecules. Advances in colloid and interface science, 237, 52-75.
DOI Scopus39 WoS41 Europe PMC21
2016 Joyce, P., Whitby, C. P., & Prestidge, C. A. (2016). Interfacial processes that modulate the kinetics of lipase-mediated catalysis using porous silica host particles. RSC advances, 6(49), 43802-43813.
DOI Scopus32 WoS31
2016 Dening, T. J., Joyce, P., Rao, S., Thomas, N., & Prestidge, C. A. (2016). Nanostructured montmorillonite clay for controlling the lipase-mediated digestion of medium chain triglycerides. ACS applied materials and interfaces, 8(48), 32732-32742.
DOI Scopus42 WoS41 Europe PMC20
2016 Joyce, P., Barnes, T. J., Boyd, B. J., & Prestidge, C. A. (2016). Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products. RSC advances, 6(82), 78385-78395.
DOI Scopus36 WoS36
2015 Joyce, P., Whitby, C. P., & Prestidge, C. A. (2015). Bioactive hybrid particles from poly(D,L -lactide-co-glycolide) nanoparticle stabilized lipid droplets. ACS applied materials and interfaces, 7(31), 17460-17470.
DOI Scopus31 WoS29 Europe PMC21
2015 Joyce, P., Kempson, I., & Prestidge, C. A. (2015). QCM-D and ToF-SIMS Investigation to Deconvolute the Relationship between Lipid Adsorption and Orientation on Lipase Activity. Langmuir, 31(37), 10198-10207.
DOI Scopus27 WoS27 Europe PMC14
2014 Joyce, P., Tan, A., Whitby, C. P., & Prestidge, C. A. (2014). The role of porous nanostructure in controlling lipase-mediated digestion of lipid loaded into silica particles. Langmuir, 30(10), 2779-2788.
DOI Scopus53 WoS52 Europe PMC32

Year Citation
2020 Joyce, P., Schultz, H. B., Meola, T. R., & Prestidge, C. A. (2020). Polymer lipid hybrid (PLH) formulations: A synergistic approach to oral delivery of challenging therapeutics. A synergistic approach to oral delivery of challenging therapeutics. In Delivery of Drugs Volume 2 Expectations and Realities of Multifunctional Drug Delivery Systems (pp. 1-27). Elsevier.
DOI Scopus6

Year Citation
2016 Prestidge, C. A., & Joyce, P. M. (2016). WO2016141413A1, Drug delivery composition comprising polymer-lipid hybrid microparticles.

  • Exploring Fucoidan’s Role as a Gut-Protective Prebiotic, Marine Bioproducts CRC, 19/01/2026 - 19/01/2028

  • Evaluating protein supplementation in ulcerative colitis (SUPP UC), Central Adelaide Local Health Network Incorporated, 27/05/2025 - 06/01/2028

  • Examining diet as adjuvant therapy in Ulcerative Colitis: a randomised placebo controlled dietary advice trial (EAT-UC RCT), The Hospital Research Foundation, 30/06/2025 - 15/10/2027

  • Omega-3 Fatty Acid Quantification in Patient Plasma Samples, Pharmako Biotechnologies Pty Ltd, 15/10/2024 - 27/08/2025

Programs I'm associated with

  • IPHD - Doctor of Philosophy
  • IHBY - Bachelor of Biomedical Research (Honours)

Date Role Research Topic Program Degree Type Student Load Student Name
2025 Principal Supervisor Targeting the Gut Microbiome to Predict and Prevent Chemotherapy-Induced Cardiotoxicity Doctor of Philosophy Doctorate Full Time Miss Nicole Chan
2025 Principal Supervisor Investigating Gut Microbial Hydrogen Sulphide (H2S) as a Biomarker and Therapeutic Target for Ulcerative Colitis Doctor of Philosophy Doctorate Full Time Miss Kate Collins
2025 Co-Supervisor The role of vitamin D in the development of chemotherapy-induced mucositis Master of Research (Medical Science) Master Full Time Mr Luca Scassa
2025 Co-Supervisor The role of vitamin D in the development of chemotherapy-induced mucositis Master of Philosophy Master Full Time Mr Luca Scassa
2024 External Supervisor Gut microbiota and endocannabinoid system interactions in cancer: understanding mechanisms to inform supportive oncology interventions Doctor of Philosophy Doctorate Full Time Miss Katrina Cao
2024 Principal Supervisor Engineering multifunctional hybrid materials for effective modulation of the gut microbiome Master of Research (Pharmaceutical Science) Master Full Time Mr Alex Hunter
2024 Co-Supervisor Gut microbiota and endocannabinoid system interactions in cancer: understanding mechanisms to inform supportive oncology interventions Doctor of Philosophy Doctorate Part Time Miss Katrina Cao
2024 Co-Supervisor Formulation Design and Development of Oral Chemotherapeutic Prodrugs: In Vitro, In Vivo, and In Silico Characterisation and Evaluation Doctor of Philosophy Doctorate Full Time Dr Ali Taheri
2024 Principal Supervisor Engineering multifunctional hybrid materials for effective modulation of the gut microbiome Master of Philosophy Master Full Time Mr Alex Hunter
2024 Principal Supervisor Improving the efficacy of lung cancer therapies through targeted nanomedicine Doctor of Philosophy Doctorate Part Time Simone Babij
2023 Principal Supervisor Understanding the Biological Performance of Plant Derived Fats and Proteins - Towards Improved Meat Analogues Doctor of Philosophy Doctorate Full Time Ms Zarnab Asif
2023 Principal Supervisor 111602 - Improving mental health therapies by targeting the gut microbiome Doctor of Philosophy Doctorate Full Time Mr Srinivas Kamath
2023 Co-Supervisor 110502 - Developing advanced oral delivery formulations for treating leukemia Doctor of Philosophy Doctorate Full Time Miss Yukta Hegishte
2023 Co-Supervisor 110496 - Lipid-based Nanocarrier Enabled Delivery for Improved T-cell Immunotherapy Doctor of Philosophy Doctorate Full Time Miss Isabella Ampelia Revesz
2022 Principal Supervisor Exploring the impact of formulation design on PUFA pharmacokinetics and biodistribution Doctor of Philosophy Doctorate Full Time Mr Amer Moh'd Mah'd Abdelhafez
2022 Co-Supervisor Optimising treatment of haematological malignancies through the development of evidence-based dose individualisation strategies Doctor of Philosophy Doctorate Part Time Mr Elias Constantinos Biris
2022 Principal Supervisor Development of a safe biomaterial-based therapy for obesity Doctor of Philosophy Doctorate Full Time Mr Amin Ariaee
2022 Co-Supervisor Conquering antimicrobial resistant Gram-negative bacteria to address unmet clinical needs Doctor of Philosophy Doctorate Full Time Anam Ahsan
2022 Co-Supervisor Developing advanced oral delivery systems for antiviral drugs Doctor of Philosophy Doctorate Full Time Miss Stephanie Stodulka
2021 Co-Supervisor Lipid-based formulations to overcome challenges in oral drugdelivery Doctor of Philosophy Doctorate Full Time Mrs Ruba Jawad Abdulrahman Almasri
2021 Co-Supervisor Design of Lipid Nanoparticles (LNPs) for mRNA-Based Cancer Vaccines Doctor of Philosophy Doctorate Part Time Ms Mitra Hosseini Kharat
2021 Co-Supervisor Lipid-based formulations to overcome challenges in oral drugdelivery Doctor of Philosophy Doctorate Full Time Mrs Ruba Almasri

Date Role Research Topic Program Degree Type Student Load Student Name
2023 - 2025 Co-Supervisor Therapeutic targeting of Cyp24a1 to mitigate 5-fluorouracil-induced gastrointestinal mucositis Master of Research (Medical Science) Master Full Time Mr Phir Thianhlun
2022 - 2023 Co-Supervisor Lipid liquid crystalline nanoparticles: a delivery system for antimicrobial photodynamic therapy Doctor of Philosophy Doctorate Full Time Mr Muhammed Awad
2020 - 2023 Co-Supervisor Beyond the gastrointestinal cell layer: replication of the complex oral absorption barrier through enhanced in vitro models for nanoparticulate oral protein delivery Doctor of Philosophy Doctorate Full Time Miss Leah Wright
2019 - 2023 Co-Supervisor Overcoming biological barriers in treating intracellular infections using lipid-based nanoparticles Doctor of Philosophy Doctorate Full Time Miss Santhni Subramaniam
2019 - 2020 Co-Supervisor Polymer-lipid hybrid microparticles enhance the intracellular uptake and activity of rifampicin against bacterially infected macrophages Doctor of Philosophy Doctorate Part Time Ms Sajedehsadat Maghrebi

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