Patrick Asare
Adelaide Medical School
Faculty of Health and Medical Sciences
Summary
Dr Asare is a post-doctoral researcher with the Inflammatory Lung Disease Research Group based in the Department of Respiratory Medicine at the University of Adelaide. He is a pharmacist interested in improving the current standard of healthcare through discovery of innovative medicines.
Research experience
Dr Asare has gained knowledge and skills required for creating novel breakthrough against cancer, inflammatory lung and cardiovascular diseases-from R&D to clinical trials. As a leader of a clinical study that seeks to investigate the repurposing of pharmaceutical products, Patrick has been able to establish a network of collaboration with clinicians and other leading research groups across hospitals and research centers in Australia. He is able to draw on his experience in patient recruitment, assessment and monitoring to successfully complete clinical research projects. Dr Asare enjoys analyzing and interpreting complex data to arrive at a valid conclusion.
Areas of expertise: Clinical trials | coordinating research activities | leading clinical research teams | compliance with SOP, GMP, safety and quality guidelines, and company and legislative regulations.
Specific Skills: Flow cytometry | Inflammatory Diseases | Scientific Writing | Patients assessment, monitoring and recruitment | Partnership Management | Stakeholder Engagement | Data Analysis | Project Management | Scientific Presentations | Clinical Trial Management | Western Blotting | RT-PCR | ELISA |Cell culture | Animal/pre-clinical studies
Publications: 17 publications since 2015 (8 conference papers, with a further 2 manuscripts in preparation).
Evidence of success and emerging reputation in the field:
- 2020 Recipient of the prestigious South Australia New Investigator Award presented by the peak society for Respiratory medicine in Australia and New Zealand (Thoracic Society of Australia and New Zealand, TSANZ).
- 2021 Selection as a finalist for National TSANZ Ann Woolock New Investigator Award (note, these prestigious awards are given to only one person per year working in Australia or New Zealand).
- 2020 Award of Royal Adelaide Hospital Medical Staff Society Research Prize
- 2021 Dean’s Commendation of Doctoral Thesis Excellence Award from the University of Adelaide.
- 2022 Appointment as Laboratory Manager of the internationally recognised Chronic Inflammatory Lung Disease Research Lab of the University of Adelaide and Royal Adelaide Hospital.
Collaborations: Dr Asare has already established collaborative networks with leading research groups and clinicians in South Australia including the Royal Adelaide Hospital (RAH), Women’s and Children’s Hospital, Basil Hetzel Institute and Robinson Institute, that ensure access to a constant source of highly valuable well-categorized human sample.
Contribution to Research, Training and Profession: Dr Asare has successfully established all techniques crucial for successful completion of projects including ex vivo, in vitro and in vivo assessment and genotyping of human and murine airway samples, western blot, siRNA, microscopy, flow cytometry and Real-Time PCR.
- 2020-present: Invited journal reviewer for Journal of Inflammation and Inflammapharmcology
- 2020-present: Training and supervising junior staff members
- 2021-2022: Co-supervisor for a master’s student (awarded higher distinction)
Society memberships and affiliations:
- 2018-present: Thoracic Society of Australia and New Zealand
- 2019-present: Asia Pacific Society for Respirology
- 2019-present: American Thoracic Society
- 2022-present: University of Adelaide Alumni
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Education
Date Institution name Country Title 2018 - 2022 University of Adelaide Australia PhD in Medicine 2013 - 2016 Tianjin University of Traditional Chinese Medicine China Master's in Medicine 2008 - 2012 University of Ghana Ghana Bachelor of Pharmacy
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Journals
Year Citation 2023 Asare, P. F., Hurtado, P. R., Tran, H. B., Perkins, G. B., Roscioli, E., & Hodge, S. (2023). Reduction in Rubicon by cigarette smoke is associated with impaired phagocytosis and occurs through lysosomal degradation pathway.. Clin Exp Med, 23(7), 4041-4055.
2023 Hodge, G., Jersmann, H., Holmes, M., Asare, P., Roscioli, E., Reynolds, P. N., & Hodge, S. (2023). BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD—The Spillover Hypothesis Explained?. Biology, 12(9), 1-13.
2022 Hodge, G., Jersmann, H., Tran, H. B., Asare, P. F., Jayapal, M., Reynolds, P. N., . . . Hodge, S. (2022). COPD is associated with increased pro-inflammatory CD28null CD8 T and NKT-like cells in the small airways. Clinical and Experimental Immunology, 207(3), 351-359.
Scopus4 WoS3 Europe PMC22022 Agyemang, K., Johansen, A. M., Barker, G. W., Pennison, M. J., Sheffield, K., Jimenez, H., . . . Pasche, B. (2022). TGFBR1*6A as a modifier of breast cancer risk and progression: advances and future prospects. npj Breast Cancer, 8(1), 9 pages.
2022 Tran, H. B., Jakobczak, R., Abdo, A., Asare, P., Reynolds, P., Beltrame, J., . . . Zalewski, P. (2022). Immunolocalization of zinc transporters and metallothioneins reveals links to microvascular morphology and functions. Histochemistry and Cell Biology, 158(5), 485-496.
Scopus4 WoS2 Europe PMC42021 Tran, H. B., Hamon, R., Jersmann, H., Ween, M. P., Asare, P., Haberberger, R., . . . Hodge, S. J. (2021). AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke. Journal of Inflammation-London, 18(1), 1-13.
Scopus8 WoS6 Europe PMC72020 Asari, P., Roscioli, E., Hurtado, P., Tran, H., Mah, C., & Hodge, S. (2020). LC3-associated phagocytosis (LAP): a potentially influential mediator of efferocytosis-related tumour progression and aggressiveness.. Frontiers in Oncology-Molecular and Cellular Oncology, 10, 14 pages.
Scopus23 WoS20 Europe PMC132017 Wang, L., Yu, J., Fordjour, P. A., Xing, X., Gao, H., Li, Y., . . . Fan, G. (2017). Danshen injection prevents heart failure by attenuating post-infarct remodeling. Journal of Ethnopharmacology, 205, 22-32.
Scopus31 Europe PMC172017 Xiaoyan, W., Pais, E. M. A., Lan, L., Jingrui, C., Lin, M., Asare, P., & Guanwei, F. (2017). MicroRNA-155: a Novel Armamentarium Against Inflammatory Diseases. Inflammation, 40(2), 708-716.
Scopus27 Europe PMC172016 Gao, H., Li, L., Li, L., Gong, B., Dong, P., Fordjour, P. A., . . . Fan, G. (2016). Danshensu Promotes Cholesterol Efflux in RAW264.7 Macrophages. Lipids, 51(9), 1083-1092.
Scopus27 Europe PMC72016 Fordjour, P. A., Wang, L., Gao, H., Li, L., Wang, Y., Nyagblordzro, M., . . . Fan, G. (2016). Targeting BNIP3 in inflammation-mediated heart failure: a novel concept in heart failure therapy. Heart Failure Reviews, 21(5), 489-497.
Scopus16 Europe PMC112016 Fan, G., Jiang, X., Wu, X., Fordjour, P. A., Miao, L., Zhang, H., . . . Gao, X. (2016). Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4–NF-κB Pathway. Inflammation, 39(1), 375-384.
Scopus87 Europe PMC512016 Xing, X., Su, L., Asare, P. F., Wang, L., Li, L., Liu, E., . . . Fan, G. (2016). Danzhi Qing'e (DZQE) activates AMPK pathway and regulates lipid metabolism in a rat model of perimenopausal hyperlipidaemia. Experimental Physiology, 101(11), 1406-1417.
Scopus9 WoS7 Europe PMC42016 Chen, J., Cao, W., Asare, P. F., Lv, M., Zhu, Y., Li, L., . . . Fan, G. (2016). Amelioration of cardiac dysfunction and ventricular remodeling after myocardial infarction by danhong injection are critically contributed by anti-TGF-β-mediated fibrosis and angiogenesis mechanisms. Journal of Ethnopharmacology, 194, 559-570.
Scopus46 WoS39 Europe PMC232016 Fan, G., Yu, J., Asare, P. F., Wang, L., Zhang, H., Zhang, B., . . . Gao, X. (2016). Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. Journal of Cellular and Molecular Medicine, 20(10), 1908-1919.
Scopus74 WoS63 Europe PMC372015 Liu, W., Wang, L., Yu, J., Asare, P. F., & Zhao, Y. Q. (2015). Gastrodin reduces blood pressure by intervening with RAAS and PPAR γ in SHRs. Evidence-based Complementary and Alternative Medicine, 2015, 8 pages.
Scopus34 WoS12 Europe PMC172015 Fordjour, P. A., Wang, Y., Shi, Y., Agyemang, K., Akinyi, M., Zhang, Q., & Fan, G. (2015). Possible mechanisms of C-reactive protein mediated acute myocardial infarction. European Journal of Pharmacology, 760, 72-80.
Scopus40 Europe PMC22 -
Conference Items
Year Citation 2021 Asare, P. F., Tran, H. B., Hurtado, P. R., Perkins, G. B., Nguyen, P., Jersmann, H., . . . Hodge, S. (2021). Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke. Poster session presented at the meeting of Therapeutic Advances in Respiratory Disease. England: SAGE PUBLICATIONS LTD.
Scopus6 WoS5 Europe PMC52021 Asare, P., Roscioli, E., Hurtado, P., Tran, H., & Hodge, S. (2021). INHIBITION OF LC3-ASSOCIATED PHAGOCYTOSIS (LAP) IN COPD AND IN RESPONSE TO CIGARETTE SMOKE. Poster session presented at the meeting of RESPIROLOGY. WILEY. 2020 Asare, P. F., Roscioli, E., Hurtado, P. R., Tran, H. B., Maiolo, S., & Hodge, S. (2020). THP-1 Macrophages Exposed to the Factors in Cigarette Smoke Exhibit Dysregulation of LC3-Associated Phagocytosis (LAP). Poster session presented at the meeting of AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. ELECTR NETWORK: AMER THORACIC SOC.
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