Pascal Duijf

APrf Pascal Duijf

Enterprise Fellow

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Associate Professor Pascal Duijf received a PhD degree in Human Genetics from Radboud University Nijmegen in the Netherlands. As a postdoctoral fellow, he trained in cancer biology and genetics at Memorial Sloan-Kettering Cancer Center in New York. He then moved to Brisbane, first to University of Queensland and then to Queensland University of Technology, to establish and lead a research group studying genomic instability in cancer. Currently, he is an Enterprise Fellow at UniSA, within the Centre for Cancer Biology and UniSA Clinical and Health Sciences. His research aims to study genomic instability in cancer in order to understand underlying mechanisms and develop new treatment options for patients. To that end, his group uses a broad range of wet-lab and dry-lab tools, including in cell biology, genome engineering, mouse models, pathology, cancer genomics, bioinformatics and computational biology.

Year Citation
2026 Dorward, E. L., Ortiz, M., Weekley, C. M., Myo Min, K. K., Duijf, P. H. G., Barreto, S. G., . . . Bonder, C. S. (2026). Unpacking the Tumor Protein D52-like Family: Roles in Intracellular Trafficking and Cancer Progression. Cells, 15(3), 252-1-252-36.
DOI
2025 Mansoori, B., Najafi, S., Mohammadi, A., AsadollahSeraj, H., Savadi, P., Mansoori, B., . . . Baradaran, B. (2025). Corrigendum to: “The synergy between miR-486–5p and tamoxifen causes profound cell death of tamoxifen-resistant breast cancer cells”(Biomedicine & Pharmacotherapy, (2021), 141, C, (111925), (S0753332221007071), 10.1016/j.biopha.2021.111925). Biomedicine and Pharmacotherapy, 192, 118474.
DOI
2025 Jakobsen, M. K., Traynor, S., Nielsen, A. Y., Dahl, C., Staehr, M., Jakobsen, S. T., . . . Gjerstorff, M. F. (2025). Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition. Journal Of Experimental & Clinical Cancer Research, 44(1, article no. 21), 1-15.
DOI Scopus12 WoS12 Europe PMC6
2025 Perera, G. S., Huang, X., Bagherjeri, F. A., Joglekar, C. M., Leo, P., Duijf, P., . . . Punyadeera, C. (2025). Rapid and selective detection of TP53 mutations in cancer using a novel conductometric biosensor. Biosensors and Bioelectronics, 276, 1-8.
DOI Scopus3 WoS3 Europe PMC1
2025 Thangavelu, P. U., Lin, C. Y., Forouz, F., Tanaka, K., Dray, E., & Duijf, P. H. G. (2025). The RB protein: more than a sentry of cell cycle entry. Trends in Molecular Medicine, online(12), 1-16.
DOI Scopus5 WoS5
2025 Zare, E., Yaghoubi, S. M., Khoshnazar, M., Jafari Dargahlou, S., Machhar, J. S., Zheng, Z., . . . Mansoori, B. (2025). MicroRNAs in Cancer immunology: master regulators of the Tumor microenvironment and immune evasion, with therapeutic potential. Cancers, 17(13, article no. 2172), 1-38.
DOI Scopus19 WoS20
2025 Rose, M., Burgess, J. T., Cheong, C. M., Richard, I., Suraweera, A., Adams, M. N., . . . Bolderson, E. (2025). The inner nuclear membrane protein, Banf1, has an essential role in triple negative breast cancer cell proliferation and survival. Scientific Reports, 15(1), 25492.
DOI Scopus1 WoS1
2024 Huang, X., Leo, P., Jones, L., Duijf, P. H. G., Hartel, G., Kenny, L., . . . Punyadeera, C. (2024). A comparison between mutational profiles in tumour tissue DNA and circulating tumour DNA in head and neck squamous cell carcinoma - a systematic review. Mutation Research - Reviews in Mutation Research, 793(108477), 1-12.
DOI Scopus11 WoS10 Europe PMC8
2024 Avalos, B. D. L. P., Paquet, N., Tropée, R., Coulombe, Y., Palacios, H., Leung, J. W., . . . Dray, E. (2024). The protein phosphatase EYA4 promotes homologous recombination (HR) through dephosphorylation of tyrosine 315 on RAD51. Nucleic Acids Research, 52(3), 1173-1187.
DOI Scopus7 WoS7 Europe PMC9
2024 Joshi, V., Stacey, A., Feng, Y., Kalita de Croft, P., Duijf, P. H. G., Simpson, P. T., . . . McCart Reed, A. E. (2024). NDRG1 is a prognostic biomarker in breast cancer and breast cancer brain metastasis. Journal of Pathology: Clinical Research, 10(2, article no. e12364), 1-16.
DOI Scopus6 WoS7 Europe PMC1
2024 Balakittnen, J., Ekanayake Weeramange, C., Wallace, D. F., Duijf, P. H. G., Cristino, A. S., Hartel, G., . . . Punyadeera, C. (2024). A novel saliva-based miRNA profile to diagnose and predict oral cancer. International Journal of Oral Science, 16(14), 1-13.
DOI Scopus46 WoS45 Europe PMC33
2024 Bhatia, S., Khanna, K. K., & Duijf, P. H. G. (2024). Targeting chromosomal instability and aneuploidy in cancer. Trends in Pharmacological Sciences, 45(3), 210-224.
DOI Scopus24 WoS24 Europe PMC19
2024 Shahrouzi, P., Forouz, F., Mathelier, A., Kristensen, V. N., & Duijf, P. H. G. (2024). Copy number alterations: a catastrophic orchestration of the breast cancer genome. Trends in Molecular Medicine, 30(8), 750-764.
DOI Scopus20 WoS21 Europe PMC18
2024 Shahrouzi, P., Azimzade, Y., Brankiewicz Kopcinska, W., Bhatia, S., Kunke, D., Richard, D., . . . Duijf, P. H. G. (2024). Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response. Breast Cancer Research, 26(1), 1-19.
DOI Scopus2 WoS2 Europe PMC3
2024 Joshi, V., Beecher, K., Lim, M., Stacey, A., Feng, Y., Jat, P. S., . . . McCart Reed, A. E. (2024). B7-H3 expression in breast cancer and brain metastasis. International Journal of Molecular Sciences, 25(7), 1-17.
DOI Scopus14 WoS16 Europe PMC12
2023 Rashidieh, B., Bain, A. L., Tria, S. M., Sharma, S., Stewart, C. A., Simmons, J. L., . . . Khanna, K. K. (2023). Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice. Experimental Hematology & Oncology, 12(1, article no. 4), 1-19.
DOI Scopus5 WoS5 Europe PMC6
2023 Adams, M. N., Croft, L. V., Urquhart, A., Saleem, M. A. M., Rockstroh, A., Duijf, P. H. G., . . . Richard, D. J. (2023). hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer. Prostate, 83(7), 628-640.
DOI Scopus7 Europe PMC8
2023 Balakittnen, J., Weeramange, C. E., Wallace, D. F., Duijf, P. H. G., Cristino, A. S., Kenny, L., . . . Punyadeera, C. (2023). Noncoding RNAs in oral cancer. Wiley Interdisciplinary Reviews: RNA, 14(3, article no. e1754), 1-45.
DOI Scopus37 Europe PMC30
2023 Bhatia, S., Gunter, J. H., Burgess, J. T., Adams, M. N., O'Byrne, K., Thompson, E. W., & Duijf, P. H. G. (2023). Stochastic epithelial-mesenchymal transitions diversify non-cancerous lung cell behaviours. Translational Oncology, 37(101760), 1-18.
DOI Scopus2 WoS2
2023 Avalos, B. D. L. P., Tropee, R., Duijf, P. H. G., & Dray, E. (2023). EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance. Molecular Cancer, 22(158), 1-18.
DOI Scopus11 WoS12 Europe PMC12
2023 Huang, X., Duijf, P. H. G., Sriram, S., Perera, G., Vasani, S., Kenny, L., . . . Punyadeera, C. (2023). Circulating tumour DNA alterations: emerging biomarker in head and neck squamous cell carcinoma. Journal of Biomedical Science, 30(1), 65.
DOI Scopus31 Europe PMC24
2023 Asl, E. R., Rostamzadeh, D., Duijf, P. H. G., Mafi, S., Mansoori, B., Barati, S., . . . Mansoori, B. (2023). Mutant P53 in the formation and progression of the tumor microenvironment: Friend or foe. Life Sciences, 315, 121361.
DOI Scopus31 Europe PMC20
2023 Mansoori, B., Kiani, S., Mezajin, A. A., Zandi, P., Banaie, H., Rostamzadeh, D., . . . Baradaran, B. (2023). MicroRNA-143-5p Suppresses ER-Positive Breast Cancer Development by Targeting Oncogenic HMGA2. Clinical Breast Cancer, 23(7), e480-e490.e3.
DOI Scopus9 Europe PMC4
2022 Derakhshani, A., Javadrashid, D., Hemmat, N., Dufour, A., Solimando, A. G., Abdoli Shadbad, M., . . . Baradaran, B. (2022). Identification of common and distinct pathways in inflammatory bowel disease and colorectal cancer: a hypothesis based on weighted gene co-expression network analysis. Frontiers in Genetics, 13(848646), 1-12.
DOI Scopus14
2021 Mansoori, B., Najafi, S., Mohammadi, A., AsadollahSeraj, H., Savadi, P., Mansoori, B., . . . Baradaran, B. (2021). The synergy between miR-486-5p and tamoxifen causes profound cell death of tamoxifen-resistant breast cancer cells. Biomedicine and Pharmacotherapy, 141(111925), 111925.
DOI Scopus10 Europe PMC9
2021 Sahin, K. B., Shah, E. T., Ferguson, G. P., Molloy, C., Duijf, P. H. G., & Adams, M. N. (2021). Elevating CDCA3 levels enhances tyrosine kinase inhibitor sensitivity in TKI-resistant EGFR mutant non-small-cell lung cancer. Cancers, 13(18, article no. 4651), 4651.
DOI Scopus11
2021 Kildey, K., Gandhi, N. S., Sahin, K. B., Shah, E. T., Boittier, E., Duijf, P. H. G., . . . Adams, M. N. (2021). Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy. Communications Biology, 4(1, article no. 638), 638.
DOI Scopus27 Europe PMC23
2021 Rashidieh, B., Molakarimi, M., Mohseni, A., Tria, S. M., Truong, H., Srihari, S., . . . Khanna, K. K. (2021). Targeting brf2 in cancer using repurposed drugs. Cancers, 13(15, article no. 3778), 3778.
DOI Scopus14
2021 Mansoori, B., Silvestris, N., Mohammadi, A., Khaze, V., Baghbani, E., Mokhtarzadeh, A., . . . Baradaran, B. (2021). Mir‐34a and mir‐200c have an additive tumor‐suppressive effect on breast cancer cells and patient prognosis. Genes, 12(2, article no. 267), 1-17.
DOI Scopus50 Europe PMC37
2021 Jakobsen, M. K., Traynor, S., Stæhr, M., Duijf, P. G., Nielsen, A. Y., Terp, M. G., . . . Gjerstorff, M. F. (2021). The cancer/testis antigen gene VCX2 is rarely expressed in malignancies but can be epigenetically activated using DNA methyltransferase and histone deacetylase inhibitors. Frontiers in Oncology, 10(584024), 1-12.
DOI Scopus20
2021 Fernando, M., Duijf, P. H. G., Proctor, M., Stevenson, A. J., Ehmann, A., Vora, S., . . . Gabrielli, B. (2021). Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours. Oncogenesis, 10(5, article no. 41).
DOI Scopus22
2021 Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., . . . Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 276(119431), 119431.
DOI Scopus43 Europe PMC35
2021 Wiegmans, A. P., Ward, A., Ivanova, E., Duijf, P. H. G., Adams, M. N., Najib, I. M., . . . Richard, D. J. (2021). Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer. NAR Cancer, 3(2, article no. zcab022), 1-11.
DOI Scopus14
2021 Safarzadeh, E., Mohammadi, A., Mansoori, B., Duijf, P. H. G., Hashemzadeh, S., Khaze, V., . . . Baradaran, B. (2021). STAT3 silencing and TLR7/8 pathway activation repolarize and suppress myeloid-derived suppressor cells from breast cancer patients. Frontiers in Immunology, 11(613215), 1-14.
DOI Scopus25 Europe PMC21
2021 Mohammadi, A., Mansoori, B., Duijf, P. H. G., Safarzadeh, E., Tebbi, L., Najafi, S., . . . Baradaran, B. (2021). Restoration of miR-330 expression suppresses lung cancer cell viability, proliferation, and migration. Journal of Cellular Physiology, 236(1), 273-283.
DOI Scopus18 Europe PMC15
2021 Tropée, R., de la Peña Avalos, B., Gough, M., Snell, C., Duijf, P. H. G., & Dray, E. (2021). The SWI/SNF subunit SMARCD3 regulates cell cycle progression and predicts survival outcome in ER+ breast cancer. Breast Cancer Research and Treatment, 185(3), 601-614.
DOI Scopus22 Europe PMC22
2021 Suraweera, A., Duijf, P. H. G., Jekimovs, C., Schrobback, K., Liu, C., Adams, M. N., . . . Richard, D. J. (2021). Commd1, from the repair of dna double strand breaks, to a novel anti-cancer therapeutic target. Cancers, 13(4, article no. 830), 1-20.
DOI Scopus6
2021 Mansoori, B., Mohammadi, A., Ditzel, H. J., Duijf, P. H. G., Khaze, V., Gjerstorff, M. F., & Baradaran, B. (2021). Hmga2 as a critical regulator in cancer development. Genes, 12(2), 1-23.
DOI Scopus161 Europe PMC151
2021 baghbani, E., Noorolyai, S., Duijf, P. H. G., Silvestris, N., Kolahian, S., Hashemzadeh, S., . . . Baradaran, B. (2021). The impact of microRNAs on myeloid-derived suppressor cells in cancer. Human Immunology, 82(9), 668-678.
DOI Scopus5 Europe PMC5
2021 Janysek, D. C., Kim, J., Duijf, P. H. G., & Dray, E. (2021). Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers. Translational Oncology, 14(3), 101012.
DOI Scopus45
2021 Suraweera, A., Duff, A., Adams, M. N., Jekimovs, C., Duijf, P. H. G., Liu, C., . . . Richard, D. J. (2021). Correction: Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer (British Journal of Cancer, (2020), 123, 4, (591-603), 10.1038/s41416-020-0899-2). British Journal of Cancer, 124(9), 1612.
DOI
2021 Wiegmans, A. P., Ward, A., Ivanova, E., Duijf, P. H. G., Adams, M. N., Najib, I. M., . . . Richard, D. J. (2021). Correction to ‘Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer’. Nar Cancer, 3(3).
DOI
2020 Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H., Mohammadi, A., Gjerstorff, M., & Baradaran, B. (2020). Corrigendum to “MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis” (Free Radical Biology and Medicine (2019) 139 (1–15), (S0891584919301844), (10.1016/j.freeradbiomed.2019.05.017)). Free Radical Biology and Medicine, 146, 402.
DOI Scopus4
2020 Naghizadeh, S., Mohammadi, A., Duijf, P. H. G., Baradaran, B., Safarzadeh, E., Cho, W. C. S., & Mansoori, B. (2020). The role of miR-34 in cancer drug resistance. Journal of Cellular Physiology, 235(10), 6424-6440.
DOI Scopus31 Europe PMC25
2020 Mansoori, B., Mohammadi, A., Naghizadeh, S., Gjerstorff, M., Shanehbandi, D., Shirjang, S., . . . Baradaran, B. (2020). miR-330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer. Journal of Cellular Physiology, 235(2), 920-931.
DOI Scopus57 Europe PMC47
2020 Mansoori, B., Duijf, P. H. G., Mohammadi, A., Najafi, S., Roshani, E., Shanehbandi, D., . . . Baradaran, B. (2020). Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness. Expert Opinion on Therapeutic Targets, 24(3), 255-265.
DOI Scopus53 Europe PMC46
2020 Abdel Fatah, T. M. A., Ball, G. R., Thangavelu, P. U., Reid, L. E., McCart Reed, A. E., Saunus, J. M., . . . Chan, S. Y. T. (2020). Association of sperm-associated antigen 5 and treatment response in patients with estrogen receptor-positive breast cancer. JAMA network open, 3(7, article no. e209486), 1-14.
DOI Scopus2 Europe PMC2
2020 Suraweera, A., Duff, A., Adams, M. N., Jekimovs, C., Duijf, P. H. G., Liu, C., . . . Richard, D. J. (2020). Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer. British Journal of Cancer, 123(4), 591-603.
DOI Scopus17 Europe PMC16
2020 Burgess, J. T., Bolderson, E., Adams, M. N., Duijf, P. H. G., Zhang, S. D., Gray, S. G., . . . O'Byrne, K. J. (2020). SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer. Scientific Reports, 10(1, article no. 18605), 1-10.
DOI Scopus23 Europe PMC23
2020 Khanna, K. K., & Duijf, P. H. G. (2020). Complexities of pharmacogenomic interactions in cancer. Molecular & Cellular Oncology, 7(3, article no. e1735910), 1735910.
DOI Scopus5
2020 Shirjang, S., Mansoori, B., Mohammadi, A., Shajari, N., Duijf, P. H. G., Najafi, S., . . . Baradaran, B. (2020). Mir-330 regulates colorectal cancer oncogenesis by targeting BACH1. Advanced Pharmaceutical Bulletin, 10(3), 444-451.
DOI Scopus26
2020 Shukla, A., Nguyen, T. H. M., Moka, S. B., Ellis, J. J., Grady, J. P., Oey, H., . . . Duijf, P. H. G. (2020). Chromosome arm aneuploidies shape tumour evolution and drug response. Nature Communications, 11(1, article no. 449), 1-14.
DOI Scopus88 Europe PMC102
2020 Duijf, P. H. G. (2020). Low baseline pulmonary levels of cytotoxic lymphocytes as a predisposing risk factor for severe COVID-19. mSystems, 5(5, article no. e00741-20), 1-13.
DOI Scopus9
2020 Fachal, L., Aschard, H., Beesley, J., Barnes, D. R., Duijf, P., & Dunning, A. M. (2020). Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nature Genetics, 52(1), 56-73.
DOI Scopus132 WoS127 Europe PMC154
2020 Sinha, D., Nag, P., Nanayakkara, D., Duijf, P. H. G., Burgess, A., Raninga, P., . . . Khanna, K. K. (2020). Cep55 overexpression promotes genomic instability and tumorigenesis in mice.. Communications Biology, 3(1), 593.
DOI Scopus32 WoS31 Europe PMC32
2019 Li, A., Geyer, F. C., Blecua, P., Lee, J. Y., Selenica, P., Brown, D. N., . . . Stone, J. (2019). Homologous recombination DNA repair defects in PALB2-associated breast cancers. npj Breast Cancer, 5(1), 23-1-23-14.
DOI Scopus46 WoS47 Europe PMC44
2019 Brown, P., Tan, A. -C., El-Esawi, M. A., Liehr, T., Blanck, O., Gladue, D. P., . . . Zhou, Y. (2019). Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database: the journal of biological databases and curation, 2019(baz085), baz085-1-baz085-66.
DOI Scopus31 WoS38 Europe PMC15
2019 Li, A., Geyer, F., Blecua, P., Lee, J., Selenica, P., Brown, D., . . . Stone, J. (2019). Publisher Correction: Homologous recombination DNA repair defects in PALB2-associated breast cancers (npj Breast Cancer, (2019), 5, 1, (23), 10.1038/s41523-019-0115-9). npj Breast Cancer, 5(1).
DOI
2019 Al Emran, A., Marzese, D. M., Menon, D. R., Hammerlindl, H., Ahmed, F., Richtig, E., . . . Schaider, H. (2019). Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer. Epigenomics, 11(7), 723-737.
DOI Scopus20 Europe PMC14
2019 Shomali, N., Shirafkan, N., Duijf, P. H. G., Ghasabi, M., Babaloo, Z., Yousefi, M., . . . Baradaran, B. (2019). Downregulation of miR-146a promotes cell migration in Helicobacter pylori-negative gastric cancer. Journal of Cellular Biochemistry, 120(6), 9495-9505.
DOI Scopus28 Europe PMC17
2019 Mansoori, B., Mohammadi, A., Asadzadeh, Z., Shirjang, S., Minouei, M., Abedi Gaballu, F., . . . Baradaran, B. (2019). HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy. Journal of Cellular Physiology, 234(10), 17714-17726.
DOI Scopus41 Europe PMC35
2019 Mansoori, B., Mohammadi, A., Gjerstorff, M. F., Shirjang, S., Asadzadeh, Z., Khaze, V., . . . Baradaran, B. (2019). miR-142-3p is a tumor suppressor that inhibits estrogen receptor expression in ER-positive breast cancer. Journal of Cellular Physiology, 234(9), 16043-16053.
DOI Scopus50 Europe PMC34
2019 Bhatia, S., Monkman, J., Blick, T., Duijf, P. H. G., Nagaraj, S. H., & Thompson, E. W. (2019). Multi-omics characterization of the spontaneous mesenchymal-epithelial transition in the PMC42 breast cancer cell lines. Journal of Clinical Medicine, 8(8, article no. 1253), 1-31.
DOI Scopus21
2019 Safarzadeh, E., Shahryar, H., Duijf, P. H. G., Mansoori, B., Khaze, V., Mohammadi, A., . . . Baradaran, B. (2019). Circulating myeloid-derived suppressor cells: An independent prognostic factor in patients with breast cancer. Journal of Cellular Physiology, 234(4), 3515-3525.
DOI Scopus72 Europe PMC67
2019 Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., . . . Gjerstorff, M. F. (2019). A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence. Cell Death and Disease, 10(11, article no. 841), 1-12.
DOI Scopus4 Europe PMC4
2019 Mansoori, B., Mohammadi, A., Ghasabi, M., Shirjang, S., Dehghan, R., Montazeri, V., . . . Baradaran, B. (2019). miR-142-3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach-1 expression. Journal of Cellular Physiology, 234(6), 9816-9825.
DOI Scopus115 Europe PMC94
2019 Sinha, D., Duijf, P. H. G., & Khanna, K. K. (2019). Mitotic slippage: an old tale with a new twist. Cell Cycle, 18(1), 7-15.
DOI Scopus117 Europe PMC108
2019 Kalimutho, M., Nones, K., Srihari, S., Duijf, P. H. G., Waddell, N., & Khanna, K. K. (2019). Patterns of Genomic Instability in Breast Cancer. Trends in Pharmacological Sciences, 40(3), 198-211.
DOI Scopus70 Europe PMC64
2019 Vahidian, F., Duijf, P. H. G., Safarzadeh, E., Derakhshani, A., Baghbanzadeh, A., & Baradaran, B. (2019). Interactions between cancer stem cells, immune system and some environmental components: Friends or foes?. Immunology Letters, 208, 19-29.
DOI Scopus72 Europe PMC59
2019 Duijf, P. H. G., Nanayakkara, D., Nones, K., Srihari, S., Kalimutho, M., & Khanna, K. K. (2019). Mechanisms of Genomic Instability in Breast Cancer. Trends in Molecular Medicine, 25(7), 595-611.
DOI Scopus143 Europe PMC119
2019 Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H. G., Mohammadi, A., Gjerstorff, M., & Baradaran, B. (2019). MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis. Free Radical Biology and Medicine, 139, 1-15.
DOI Scopus152 Europe PMC112
2019 Ghasabi, M., Mansoori, B., Mohammadi, A., Duijf, P. H. G., Shomali, N., Shirafkan, N., . . . Baradaran, B. (2019). MicroRNAs in cancer drug resistance: Basic evidence and clinical applications. Journal of Cellular Physiology, 234(3), 2152-2168.
DOI Scopus68 Europe PMC47
2019 Asadzadeh, Z., Mansoori, B., Mohammadi, A., Aghajani, M., Haji-Asgarzadeh, K., Safarzadeh, E., . . . Baradaran, B. (2019). microRNAs in cancer stem cells: Biology, pathways, and therapeutic opportunities. Journal of Cellular Physiology, 234(7), 10002-10017.
DOI Scopus92 Europe PMC67
2018 Hosseinahli, N., Aghapour, M., Duijf, P. H. G., & Baradaran, B. (2018). Treating cancer with microRNA replacement therapy: A literature review. Journal of Cellular Physiology, 233(8), 5574-5588.
DOI Scopus279 Europe PMC213
2018 Lin, C. Y., Shukla, A., Grady, J. P., Fink, J. L., Dray, E., & Duijf, P. H. G. (2018). Translocation breakpoints preferentially occur in euchromatin and acrocentric chromosomes. Cancers, 10(1), 1-19.
DOI Scopus18
2018 Lin, C. Y., Beattie, A., Baradaran, B., Dray, E., & Duijf, P. H. G. (2018). Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress. Scientific Reports, 8(1, article no. 13904), 1-12.
DOI Scopus30 Europe PMC25
2018 Joo, J. E., Dowty, J. G., Milne, R. L., Wong, E. M., Duijf, P., & Antill, Y. (2018). Heritable DNA methylation marks associated with susceptibility to breast cancer. Nature Communications, 9(1, article number 867), 1-12.
DOI Scopus84 Europe PMC82
2018 Shajari, N., Davudian, S., Kazemi, T., Mansoori, B., Salehi, S., Shahgoli, V. K., . . . Baradaran, B. (2018). Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression. Artificial Cells, Nanomedicine and Biotechnology, 46(7), 1495-1504.
DOI Scopus50 Europe PMC47
2018 Kalimutho, M., Sinha, D., Jeffery, J., Nones, K., Srihari, S., Fernando, W. C., . . . Khanna, K. K. (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10(9, article no. e8566), 1-22.
DOI Scopus71 Europe PMC68
2017 Thangavelu, P. U., Lin, C. Y., Vaidyanathan, S., Nguyen, T. H. M., Dray, E., & Duijf, P. H. G. (2017). Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer. OncoTarget, 8(37), 62167-62182.
DOI Scopus43 Europe PMC34
2016 Vaidyanathan, S., Cato, K., Tang, L., Pavey, S., Haass, N. K., Gabrielli, B. G., & Duijf, P. H. G. (2016). In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. Oncogene, 35(41), 5446-5455.
DOI Scopus49 Europe PMC49
2016 Vaidyanathan, S., Thangavelu, P. U., & Duijf, P. H. G. (2016). Overexpression of Ran GTPase components regulating nuclear export, but not mitotic spindle assembly, marks chromosome instability and poor prognosis in breast cancer. Targeted Oncology, 11(5), 677-686.
DOI Scopus40 Europe PMC34
2016 Thangavelu, P. U., Krenács, T., Dray, E., & Duijf, P. H. G. (2016). In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion. Clinical Epigenetics, 8(1, article no. 120), 1-13.
DOI Scopus68 Europe PMC62
2013 Duijf, P. H. G., Schultz, N., & Benezra, R. (2013). Cancer cells preferentially lose small chromosomes. International Journal of Cancer, 132(10), 2316-2326.
DOI Scopus144 Europe PMC146
2013 Duijf, P. H. G., & Benezra, R. (2013). The cancer biology of whole-chromosome instability. Oncogene, 32(40), 4727-4736.
DOI Scopus96 Europe PMC99
2011 Schvartzman, J. M., Duijf, P. H. G., Sotillo, R., Coker, C., & Benezra, R. (2011). Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell, 19(6), 701-714.
DOI Scopus154 Europe PMC156
2008 Rinne, T., Clements, S. E., Lamme, E., Duijf, P. H. G., Bolat, E., Meijer, R., . . . Van Bokhoven, H. (2008). A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes. Human Molecular Genetics, 17(13), 1968-1977.
DOI Scopus59 Europe PMC50
2006 Rinne, T., Spadoni, E., Kjaer, K. W., Danesino, C., Larizza, D., Kock, M., . . . van Bokhoven, H. (2006). Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene. European Journal of Human Genetics, 14(8), 904-910.
DOI Scopus45 Europe PMC34
2005 Duijf, P. H. G., & van Bokhoven, H. (2005). Ectodermal dysplasia: Skinny models on the catwalk. Drug Discovery Today Disease Models, 2(2), 111-118.
DOI
2004 Bongers, E. M. H. F., Duijf, P. H. G., Van Beersum, S. E. M., Schoots, J., Van Kampen, A., Burckhardt, A., . . . Van Bokhoven, H. (2004). Mutations in the human TBX4 gene cause small patella syndrome. American Journal of Human Genetics, 74(6), 1239-1248.
DOI Scopus151 Europe PMC140
2003 Duijf, P. H. G., van Bokhoven, H., & Brunner, H. G. (2003). Pathogenesis of split-hand/split-foot malformation. Human Molecular Genetics, 12(REV. ISS. 1), R51-R60.
DOI Scopus180 Europe PMC134
2002 Ghioni, P., Bolognese, F., Duijf, P. H. G., Van Bokhoven, H., Mantovani, R., & Guerrini, L. (2002). Complex transcriptional effects of p63 isoforms: Identification of novel activation and repression domains. Molecular and Cellular Biology, 22(24), 8659-8668.
DOI Scopus203 Europe PMC172
2002 Duijf, P. H. G., Vanmolkot, K. R. J., Propping, P., Friedl, W., Krieger, E., McKeon, F., . . . Van Bokhoven, H. (2002). Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. Human Molecular Genetics, 11(7), 799-804.
DOI Scopus113 Europe PMC90
2002 Serber, Z., Lai, H. C., Yang, A., Ou, H. D., Sigal, M. S., Kelly, A. E., . . . Dötsch, V. (2002). A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism. Molecular and Cellular Biology, 22(24), 8601-8611.
DOI Scopus178 Europe PMC155
2001 McGrath, J. A., Duijf, P. H. G., Doetsch, V., Irvine, A. D., De Waal, R., Vanmolkot, K. R. J., . . . Van Bokhoven, H. (2001). Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Human Molecular Genetics, 10(3), 221-229.
DOI Scopus348 Europe PMC278
2001 Van Bokhoven, H., Hamel, B. C. J., Bamshad, M., Sangiorgi, E., Gurrieri, F., Duijf, P. H. G., . . . Brunner, H. G. (2001). p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. American Journal of Human Genetics, 69(3), 481-492.
DOI Scopus331 Europe PMC260
1999 Celli, J., Duijf, P., Hamel, B. C. J., Bamshad, M., Kramer, B., Smits, A. P. T., . . . Van Bokhoven, H. (1999). Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell, 99(2), 143-153.
DOI Scopus616 Europe PMC510
  • Targeting a common genetic alteration in glioblastoma, Neurosurgical Research Foundation, 16/09/2024 - 15/09/2026

  • Targeting genetic defects in glioblastoma, Neurosurgical Research Foundation, 15/09/2024 - 12/09/2025

Courses I teach

  • MEDI 3014 Current Topics in Medical Research (2024)

Date Role Research Topic Program Degree Type Student Load Student Name
2026 Principal Supervisor Predicting drug resistance from chemical properties and gene/protein expression Doctor of Philosophy Doctorate Full Time Mr Rieley Peter Andrew West
2025 Principal Supervisor Targeting the functional consequences on aneuploidies in glioblastoma Doctor of Philosophy Doctorate Full Time Mr Ming Phong
2024 Co-Supervisor Investigating the origins and progression of pancreatic cancer Doctor of Philosophy Doctorate Full Time Miss Emma Luise Dorward
2024 Principal Supervisor Development of new treatments for glioblastoma Doctor of Philosophy Doctorate Full Time Ms Shervindokht Farhangfar

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