Oveis Pourmehran

Dr Oveis Pourmehran

Grant-Funded Researcher (A)

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Oveis Pourmehran began research in the field of targeted drug delivery during his master program (2013-2015), in which he developed several computational fluid dynamics (CFD) models to computationally simulate magnetic drug targeting to improve the efficiency of drug delivery to the human lungs.

In 2017, Oveis joined the University of Adelaide (Australia) as a PhD candidate and completed his PhD thesis titled "Understanding the flow behaviour in human maxillary sinuses for drug delivery applications" with the School of Mechanical Engineering in 2021. His Ph.D. program has contributed to the development of an advanced technique for drug delivery to the human sinuses using a tailored acoustic wave. In this research program, for the first time, he developed a high-fidelity direct computational aero-acoustic model to investigate the effect of the acoustic wave on drug delivery to the human maxillary sinuses, which shed new insight into the acoustic drug delivery technique. Also, his experiments showed that the acoustic drug delivery technique has the potential to increase drug delivery efficiency >45-fold when compared to the conventional nebulised drug delivery method.

Since June 2021, Oveis has joined the Department of Otolaryngology, Head and Neck Surgery, Adelaide Medical School, at the University of Adelaide as a postdoctoral research fellow, and established a Biomedical Engineering Research Node to develop novel drug delivery methods/devices to improve treatment efficiency in human upper airway diseases. Jointly with lead researchers and scientists from the ENT research group at the medical school and researchers at the school of mechanical engineering, he, as a chief investigator, has been awarded several research grants totaling>$2m (2022-2025), to develop cutting-edge techniques/devices for drug delivery to the upper airways and to the sinuses for CF and CRS treatment.

Media appearances:
https://set.adelaide.edu.au/news/list/2022/02/18/mechanical-engineering-phd-concept-developed-for-use-in-medical-clinical
https://www.schoolandcollegelistings.com/AU/Adelaide/321219921227571/Basil-Hetzel-Institute-for-Translational-Health-Research

As a multi-disciplinary research team, the ENT surgery group, managed by Prof Peter-John Wormald, has recently established a Biomedical Engineering research node, mentored by Oveis Pourmehran, to develop novel drug delivery methods/devices for the improvement of the treatment efficiency in upper airway diseases.

The following research topics are available for PhD applicants, HDR, Honours, and 3rd Year students in 2022:

  • Acoustic drug delivery to paranasal sinuses.
  • Development of a mesh nebuliser for improvement of sinus drug delivery.
  • Virtual endoscopic sinus surgery (ESS) followed by airflow analysis and particle tracking in the nasal cavity and paranasal sinuses.
  • Magnetic & electric-charged particle (drug) delivery to human lung and paranasal sinuses.

The following techniques/skills are exploited to conduct these research projects: Computational fluid dynamics (CFD), particle tracking using DPM-CFD, finite element analysis (FEA), signal processing (acoustics), computer-aided design (CAD) modelling, CT-scan reconstruction (3D Slicer and other potential software), and cutting-edge 3D printing technology (e.g., FUSETEC).

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  • Journals
    Year Citation
    2022 Pourmehran, O., Cazzolato, B., Tian, Z., & Arjomandi, M. (2022). The effect of inlet flow profile and nozzle diameter on drug delivery to the maxillary sinus. Biomechanics and Modeling in Mechanobiology, 21(3), 849-870.
    DOI
    2021 Pourmehran, O., Arjomandi, M., Cazzolato, B., Tian, Z., Vreugde, S., Javadiyan, S., . . . Wormald, P. -J. (2021). Acoustic drug delivery to the maxillary sinus.. Int J Pharm, 606, 1-15.
    DOI Scopus3 WoS3 Europe PMC1
    2021 Islam, M. S., Larpruenrudee, P., Saha, S. C., Pourmehran, O., Paul, A. R., Gemci, T., . . . Gu, Y. (2021). How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways. Physics of Fluids, 33(8), 081911-1-081911-13.
    DOI Scopus8 WoS6 Europe PMC1
    2021 Taheri, M. H., Pourmehran, O., Sarafraz, M. M., Ahookhosh, K., Farnoud, A., & Cui, X. (2021). Effect of swirling flow and particle-release pattern on drug delivery to human tracheobronchial airways. Biomechanics and Modeling in Mechanobiology, 20(6), 2451-2469.
    DOI Scopus4 WoS3 Europe PMC2
    2020 Sarafraz, M. M., Pourmehran, O., Yang, B., Arjomandi, M., & Ellahi, R. (2020). Pool boiling heat transfer characteristics of iron oxide nano-suspension under constant magnetic field. International Journal of Thermal Sciences, 147, 106131.
    DOI Scopus94 WoS94
    2020 Ahookhosh, K., Pourmehran, O., Aminfar, H., Mohammadpourfard, M., Sarafraz, M. M., & Hamishehkar, H. (2020). Development of Human Respiratory Airway Models: A Review.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 145, 1-22.
    DOI Scopus23 WoS20 Europe PMC2
    2020 Arya, H., Sarafraz, M. M., Pourmehran, O., & Arjomandi, M. (2020). Performance index improvement of a double-pipe cooler with MgO/water-ethylene glycol (50:50) nano-suspension. Propulsion and Power Research, 9(1), 75-86.
    DOI Scopus4 WoS3
    2020 Pourmehran, O., Cazzolato, B., Tian, Z., & Arjomandi, M. (2020). Acoustically-driven drug delivery to maxillary sinuses: aero-acoustic analysis. European Journal of Pharmaceutical Sciences, 151, 1-14.
    DOI Scopus7 WoS7 Europe PMC2
    2019 Arya, H., Sarafraz, M. M., Pourmehran, O., & Arjomandi, M. (2019). Heat transfer and pressure drop characteristics of MgO nanofluid in a double pipe heat exchanger. Heat and Mass Transfer, 55(6), 1769-1781.
    DOI Scopus24 WoS17
    2019 Sarafraz, M., Pourmehran, O., Yang, B., & Arjomandi, M. (2019). Assessment of the thermal performance of a thermosyphon heat pipe using zirconia-acetone nanofluids. Renewable Energy, 136, 884-895.
    DOI Scopus81 WoS72
    2019 Sarafraz, M., Yang, B., Pourmehran, O., Arjomandi, M., & Ghomashchi, R. (2019). Fluid and heat transfer characteristics of aqueous graphene nanoplatelet (GNP) nanofluid in a microchannel. International Communications in Heat and Mass Transfer, 107, 24-33.
    DOI Scopus69 WoS64
    2019 Sarafraz, M. M., Silakhori, M., Madani, S. A., Kiamahalleh, M. V., & Pourmehran, O. (2019). Thermal and hydraulic performance of a heat exchanger working with carbon-water nanofluid. Heat and Mass Transfer/Waerme- und Stoffuebertragung, 55(12), 3443-3453.
    DOI Scopus6 WoS6
    2019 Pourmehran, O., Arjomandi, M., Cazzolato, B., Ghanadi, F., & Tian, Z. (2019). The impact of geometrical parameters on acoustically driven drug delivery to maxillary sinuses.. Biomech Model Mechanobiol, 19(2), 557-575.
    DOI Scopus10 WoS9 Europe PMC2
    2018 Tabassum, R., Mehmood, R., Pourmehran, O., Akbar, N. S., & Gorji-Bandpy, M. (2018). Impact of viscosity variation on oblique flow of Cu–H2O nanofluid. Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, 232(5), 622-631.
    DOI Scopus23 WoS18
    2018 Mehmood, R., Tabassum, R., Pourmehran, O., & Ganji, D. D. (2018). Crosswise stream of hydrogen-oxide (H2O) through a porous media containing copper nanoparticles. International Journal of Hydrogen Energy, 43(15), 7562-7569.
    DOI Scopus14 WoS13
    2018 Pourmehran, O., Sarafraz, M., Rahimi-Gorji, M., & Ganji, D. (2018). Rheological behaviour of various metal-based nano-fluids between rotating discs: a new insight. Journal of the Taiwan Institute of Chemical Engineers, 88, 37-48.
    DOI Scopus57 WoS52
    2018 Sarafraz, M., Pourmehran, O., Nikkhah, V., & Arya, A. (2018). Pool boiling heat transfer to zinc oxide-ethylene glycol nano-suspension near the critical heat flux. Journal of Mechanical Science and Technology, 32(5), 2309-2315.
    DOI Scopus8 WoS6
    2018 Tabasum, R., Mehmood, R., & Pourmehran, O. (2018). Velocity slip in mixed convective oblique transport of titanium oxide/water (nano-polymer) with temperature-dependent viscosity. European Physical Journal Plus, 133(9), 1-12.
    DOI Scopus11 WoS11
    2018 Mohammadian, M., Pourmehran, O., & Ju, P. (2018). An Iterative Approach to Obtaining the Nonlinear Frequency of a Conservative Oscillator with Strong Nonlinearities. International Applied Mechanics, 54(4), 470-479.
    DOI Scopus8
    2017 Pourmehran, O., Rahimi-Gorji, M., & Ganji, D. D. (2017). ANALYSIS OF NANOFLUID FLOW IN A POROUS MEDIA ROTATING SYSTEM BETWEEN TWO PERMEABLE SHEETS CONSIDERING THERMOPHORETIC AND BROWNIAN MOTION. THERMAL SCIENCE, 21(6), 3063-3073.
    DOI WoS13
    2017 Biglarian, M., Rahimi Gorji, M., Pourmehran, O., & Domairry, G. (2017). H<inf>2</inf>O based different nanofluids with unsteady condition and an external magnetic field on permeable channel heat transfer. International Journal of Hydrogen Energy, 42(34), 22005-22014.
    DOI Scopus50 WoS54
    2017 Yousefi, M., Pourmehran, O., Gorji-Bandpy, M., Inthavong, K., Yeo, L., & Tu, J. (2017). CFD simulation of aerosol delivery to a human lung via surface acoustic wave nebulization. Biomechanics and Modeling in Mechanobiology, 16(6), 2035-2050.
    DOI Scopus47 WoS45 Europe PMC9
    2017 Mosayebidorcheh, S., Rahimi-Gorji, M., Ganji, D. D., Moayebidorcheh, T., Pourmehran, O., & Biglarian, M. (2017). Transient thermal behavior of radial fins of rectangular, triangular and hyperbolic profiles with temperature-dependent properties using DTM-FDM. Journal of Central South University, 24(3), 675-682.
    DOI Scopus41 WoS38
    2016 Pourmehran, O., Rahimi-Gorji, M., & Ganji, D. D. (2016). Heat transfer and flow analysis of nanofluid flow induced by a stretching sheet in the presence of an external magnetic field. Journal of the Taiwan Institute of Chemical Engineers, 65, 162-171.
    DOI Scopus68 WoS59
    2016 Pourmehran, O., Gorji, T. B., & Gorji-Bandpy, M. (2016). Magnetic drug targeting through a realistic model of human tracheobronchial airways using computational fluid and particle dynamics. Biomechanics and Modeling in Mechanobiology, 15(5), 1355-1374.
    DOI Scopus66 WoS55 Europe PMC13
    2016 Rahimi-Gorji, M., Pourmehran, O., Gorji-Bandpy, M., & Ganji, D. D. (2016). Unsteady squeezing nanofluid simulation and investigation of its effect on important heat transfer parameters in presence of magnetic field. Journal of the Taiwan Institute of Chemical Engineers, 67, 467-475.
    DOI Scopus90 WoS87
    2015 Pourmehran, O., Rahimi-Gorji, M., Hatami, M., Sahebi, S. A. R., & Domairry, G. (2015). Numerical optimization of microchannel heat sink (MCHS) performance cooled by KKL based nanofluids in saturated porous medium. Journal of the Taiwan Institute of Chemical Engineers, 55, 49-68.
    DOI Scopus128 WoS117
    2015 Pourmehran, O., Rahimi-Gorji, M., Gorji-Bandpy, M., & Gorji, T. B. (2015). Simulation of magnetic drug targeting through tracheobronchial airways in the presence of an external non-uniform magnetic field using Lagrangian magnetic particle tracking. Journal of Magnetism and Magnetic Materials, 393, 380-393.
    DOI Scopus76 WoS68
    2015 Rahimi-Gorji, M., Pourmehran, O., Gorji-Bandpy, M., & Gorji, T. B. (2015). CFD simulation of airflow behavior and particle transport and deposition in different breathing conditions through the realistic model of human airways. Journal of Molecular Liquids, 209, 121-133.
    DOI Scopus125 WoS117
    2015 Rahimi-Gorji, M., Pourmehran, O., Hatami, M., & Ganji, D. D. (2015). Statistical optimization of microchannel heat sink (MCHS) geometry cooled by different nanofluids using RSM analysis. European Physical Journal Plus, 130(2), 1-21.
    DOI Scopus146 WoS135
    2015 Pourmehran, O., Rahimi-Gorji, M., Gorji-Bandpy, M., & Baou, M. (2015). Comparison between the volumetric flow rate and pressure distribution for different kinds of sliding thrust bearing. Propulsion and Power Research, 4(2), 84-90.
    DOI Scopus25
    2015 Tavana, M., Pourmehran, O., Aghaei Khasraghei, A., Gorji-Bandpy, M., & Alipour Sangarab, J. (2015). Numerical analysis of fluid flow and heat transfer in microchannels with various internal fins. International Journal of Artificial Intelligence and Mechatronics, 3(4), 227-230.

  • Conference Papers
    Year Citation
    2020 Pourmehran, O., Cazzolato, B., Tian, Z., & Arjomandi, M. (2020). Acoustic Behaviour of the Human Maxillary Sinus: The Importance of the Middle Meatus and the Ostium on Resonance Frequency Behaviour. In AIP (American Institute of Physics) Conference Proceedings Vol. 2425. online: AIP.
    DOI
    2020 Pourmehran, O., Arjomandi, M., Cazzolato, B., & Tian, Z. (2020). Effect of Particle Diameter and Density on Acoustic Drug Delivery to Maxillary Sinus – a Sensitivity Study. In Proceedings of the 22nd Australasian Fluid Mechanics Conference AFMC2020 (pp. 1-4). online: The University of Queensland.
    DOI

2022-2025: NHMRC Medical Research Future Fund (#2014977), 'The AIRSPACE Trial: AntI-MRSA PhAge Cocktail treatment via Acoustic Enhanced Nebulisers', (CIs: Wormald, Vreudge, Psaltis, Morales, Pourmehran, Cazzolato, Arjomandi, Louise, Schubert). Role: Chief Investigator E ($1,712,000).

2022-2025: Passe & Williams Foundation - Conjoint Grant, 'Acoustic Drug Delivery for CRS Treatment', (CIs: Wormald, Pourmehran). Role: Chief Investigator B ($375,000).

  • Position: Grant-Funded Researcher (A)
  • Phone: 0881334002
  • Email: oveis.pourmehran@adelaide.edu.au
  • Campus: North Terrace
  • Building: TQEH- Basil Hetzel Institute
  • Org Unit: Surgical Specialities
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