University Postdoctoral Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Nigel Farrow completed his PhD at the University of Adelaide in 2015 and was awarded a Dean's Commendation for Doctoral Thesis Excellence for his PhD thesis titled "Cystic Fibrosis: The role of airway stem cells in sustained gene expression by lentiviral directed gene therapy. In 2015 Nigel was also awarded the Pride of Australia medal. Nigel’s research is focused on correcting the genetic cause of cystic fibrosis at a cellular level in the airways. To achieve this a modified virus is used as a transport mechanism to introduce a healthy copy of the cystic fibrosis gene into the airway cells. Not only is the gene inserted into the cell but we have chosen a virus that has the ability to insert the gene into the genome of the recipient allowing stable gene integration for the life of the cells.
The next step is that the cells have a life span so they are eventually lost and the procedure would have to be repeated. To combat the loss of the cells he is developing a way to target the adult stem cells that live in the airway and replace the cells as they die off as a natural process. By targeting the airway stem cells for inserting a healthy copy of the CF gene then they will pass on the healthy CF gene to their daughter cells. This has the potential of providing a means to prevent cystic fibrosis airway disease with a single treatment early in life that will last for the lifetime of the patient.
Nigel is also researching an alternative approach and has demonstrated that the airway stem cells can be removed from the lungs and treated with the viral vector to insert a gene. The cells can then be grown in the lab to expand the numbers before transplanting them back into a conditioned airway.
Nigel’s work has been accepted and published in the greater scientific community through peer reviewed scientific journal publications. Nigel has also been invited to present his work at conferences in Australia, New Zealand, the United Kingdom and the USA.
Year Citation 2019 Morgan, K. S., Gradl, R., Dierolf, M., Jud, C., Günther, B., Werdiger, F., . . . Donnelley, M. (2019). In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source. In B. Müller, & G. Wang (Eds.), Developments in X-Ray Tomography XII Vol. 11113 (pp. 111130G-1-111130G-12). online: Society of Photo-optical Instrumentation Engineers.
2016 Donnelley, M., Morgan, K., Farrow, N., Siu, K., & Parsons, D. (2016). Non-invasive airway health measurement using synchrotron X-ray microscopy of high refractive index glass microbeads. In M. DeJonge, D. Paterson, & C. Ryan (Eds.), AIP Conference Proceedings Vol. 1696 (pp. 4 pages). Australian Synchrotron, Melbourne, AUSTRALIA: AMER INST PHYSICS.
DOI Scopus6 WoS5
Year Citation 2018 Farrow, N., Cmielewski, P., Donnelley, M., Rout-Pitt, N., Bertoncello, I., & Parsons, D. (2018). Epithelial Disruption Enables Human Airway Stem Cell Transplantation in Mouse Nasal Airways. Poster session presented at the meeting of MOLECULAR THERAPY. Chicago, IL: CELL PRESS. 2017 Farrow, N., Donnelley, M., McIntyre, C., Rout-Pitt, N., & Parsons, D. (2017). Developing high efficiency gene transfer techniques using human air liquid interface cultures. Poster session presented at the meeting of TSANZ Poster presentations, as published in Respirology. Canberra: Wiley. 2017 Farrow, N., Donnelley, M., Rout-Pitt, N., McIntyre, C., Bertoncello, I., & Parsons, D. W. (2017). High Efficiency In Vitro Transduction of Human Airway Basal Cells. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: CELL PRESS. 2015 Devereux, S., Cmielewski, P., Farrow, N., & Parsons, D. (2015). Airway Pre-Treatment Enhances Mouse Lung Lentiviral Reporter Gene Expression. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP.
2015 McIntyre, C., Craig, F., Cmielewski, P., Donnelley, M., Farrow, N., & Parsons, D. (2015). Comparing the Efficacy of Tat-Dependent and Tat-Independent Lentiviral Vectors. Poster session presented at the meeting of MOLECULAR THERAPY. New Orleans, LA: NATURE PUBLISHING GROUP.
2015 Farrow, N., McQualter, J., Donnelley, M., Cmielewski, P., Bertoncello, I., & Parsons, D. (2015). CYSTIC FIBROSIS MOUSE MODELS DISPLAY AGE DEPENDENT AIRWAY STEM/PROGENITOR CELL HYPERPLASIA. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2014 Farrow, N., McQualter, J., Donnelley, M., Bertoncello, I., & Parsons, D. (2014). GENE THERAPY FOR CF: IS LONG TERM EXPRESSION A CONSEQUENCE OF TRANSDUCING CONDUCTING AIRWAY ENDOGENOUS RESPIRATORY STEM CELLS?. Poster session presented at the meeting of PEDIATRIC PULMONOLOGY. WILEY-BLACKWELL. 2014 Cmielewski, P., Farrow, N., McIntyre, C., Padmanabhan, H., Donnelley, M., Kuchel, T., & Parsons, D. W. (2014). Lentiviral Airway Gene Transfer in Normal Ferrets. Poster session presented at the meeting of MOLECULAR THERAPY. Washington, DC: NATURE PUBLISHING GROUP. 2013 Farrow, N., McQualter, J., Parsons, D., & Bertoncello, I. (2013). Endogenous stem/progenitor cell compartments of conducting airways differ in cystic fibrosis and normal mice. Poster session presented at the meeting of HUMAN GENE THERAPY. Univ London, Royal Holloway, Egham, ENGLAND: MARY ANN LIEBERT INC.
CI Channel 7 Children’s Research Foundation Grant 2019 $34,625
AI Women’s and Children’s Hospital Foundation Grant 2019-20 1 $75,000
AI Women’s and Children’s Hospital Foundation Grant 2019-20 2 $75,000
CI MS McLeod Postdoctoral Research Fellowship 2019-21 $310,000
CI University of Pennsylvania, pilot grant program 2019 $73,783
CI Robinson Research Institute research travel award 2018 $2,000.00
AI Women’s and Children’s Hospital Foundation Grant 2018-19 $75,240
CI Cure 4 Cystic Fibrosis Foundation Grant 2018 $30,374
CI Women’s and Children’s Hospital Foundation Grant 2017-18 $72,975
CI AMP tomorrow fund 2017 $25,000
Robinson Research Institute research travel award 2017 $850.00
CI Cystic fibrosis South Australia research fund 2016 $30,000
Robinson Research Institute international research travel award 2015 $2,200
Robinson Research Institute international research travel award 2014 $2,200
CI MS McLeod foundation PhD scholarship $75,000
Cystic Fibrosis Australia PhD scholarship $15,000
Robinson institute centre for stem cell research honours scholarship $5,000
Robinson institute centre for stem cell research summer scholarship $2,000
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 Co-Supervisor Lentiviral Mediated Airway Gene Therapy: Is Iysophosphatidylcholine required for safe and effective gene transfer in a cystic fibrosis lung? Doctor of Philosophy Doctorate Full Time Ms Chantelle Lee Carpentieri
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