Mrs Nicole Isaacs

Senior Research Officer

Adelaide Medical School

Faculty of Health and Medical Sciences

My Research
Career
Publications
Contact

Senior Research Officer and Clinical Trials Coordinator

Education

Date Institution name Country Title

1996 - 1997 University of Adelaide Australia Bachelor of Science (Hons)

1992 - 1996 University of Adelaide Australia Bachelor of Science
Certifications

Date Title Institution name Country

— Certificate IV in Veterinary Nursing TAFE SA - Gilles Plains Campus Australia
Research Interests

Animal Cell and Molecular Biology Animal Nutrition Biochemistry & Molecular Biology Biochemistry and Cell Biology Biological Sciences Cell Biology Clinical Sciences Clinical Trials Medical and Health Sciences Medical Bacteriology Medical Biochemistry and Metabolomics Microscopy Nutrition and Metabolic Health Translational Health Outcomes

Date	Institution name	Country	Title
1996 - 1997	University of Adelaide	Australia	Bachelor of Science (Hons)
1992 - 1996	University of Adelaide	Australia	Bachelor of Science

Date	Title	Institution name	Country
—	Certificate IV in Veterinary Nursing	TAFE SA - Gilles Plains Campus	Australia

Journals

Year	Citation
2021	Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., . . . Keating, D. J. (2021). A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans. Gastroenterology, 161(2), 536-547. DOI Scopus12 WoS10 Europe PMC5
2019	Lumsden, A. L., Martin, A. M., Sun, E. W., Schober, G., Isaacs, N. J., Pezos, N., . . . Keating, D. J. (2019). Sugar responses of human enterochromaffin cells depend on gut region, sex, and body mass. Nutrients, 11(2), 1-13. DOI Scopus19 WoS15 Europe PMC12
2018	Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889. DOI Scopus64 WoS47 Europe PMC34
2017	Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans. Clinical Nutrition, 36(2), 1-6. DOI Scopus15 WoS13 Europe PMC12
2017	Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. International Journal of Obesity, 41(2), 233-239. DOI Scopus16 WoS13 Europe PMC13
2014	Little, T., Isaacs, N., Young, R., Ott, R., Nguyen, N., Rayner, C., . . . Feinle-Bisset, C. (2014). Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(10), G958-G967. DOI Scopus46 WoS36 Europe PMC25
2013	Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A., . . . Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591(7), 1921-1934. DOI Scopus70 WoS66 Europe PMC48
2013	Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2. DOI Scopus36 WoS34 Europe PMC26
2013	Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T., . . . Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62(10), 3532-3541. DOI Scopus89 WoS73 Europe PMC57
2013	Harrington, A., Brierley, S., Isaacs, N., Young, R., & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25(10), 660-668. DOI Scopus20 WoS14 Europe PMC10
2013	Li, H., Kentish, S., Kritas, S., Young, R., Isaacs, N., O'Donnell, T., . . . Page, A. (2013). Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W. Acta Physiologica (Print Edition), 209(2), 179-191. DOI Scopus17 WoS18 Europe PMC8
2013	Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465. DOI Scopus171 WoS148 Europe PMC119
2012	Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255. DOI Scopus59 WoS53 Europe PMC33
2012	Kentish, S., Li, H., Philp, L., O'Donnell, T., Isaacs, N., Young, R., . . . Page, A. (2012). Diet-induced adaptation of vagal afferent function. Journal of Physiology-London, 590(1), 209-221. DOI Scopus105 WoS99 Europe PMC72
2011	Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468. DOI Scopus127 WoS104 Europe PMC90
2010	Isaacs, N. J., Young, R. L., Wittert, G., Blackshaw, L. A., & Page, A. J. (2010). Anatomy of gastric vagal afferent innervation in normal and obese mice. NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9.
2010	Young, R., Page, A., Isaacs, N., Flach, C., & Blackshaw, L. (2010). Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves. Gastroenterology, 138(3), 1091-1106. DOI Scopus54 WoS32 Europe PMC23
2009	Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095. DOI Scopus233 WoS206 Europe PMC166
2009	Page, A., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2009). Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function. Journal of Neuroscience, 29(22), 7246-7255. DOI Scopus39 WoS33 Europe PMC26
2008	Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N., . . . Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134(7), 2059-2069. DOI Scopus225 WoS188 Europe PMC160
2008	Young, R., Isaacs, N., & Blackshaw, L. (2008). Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways. Neuropharmacology, 54(6), 965-975. DOI Scopus24 WoS22 Europe PMC15
2008	Young, R., Isaacs, N., & Blackshaw, L. (2008). Chemical coding and central projections of gastric vagal afferent neurons. Neurogastroenterology and Motility, 20(6), 708-718. DOI Scopus30 WoS24 Europe PMC19
2007	Young, R., Page, A., Isaacs, N., O'Donnell, T., & Blackshaw, L. (2007). Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G501-G511. DOI Scopus39 WoS32 Europe PMC29
2007	Sutherland, K., Young, R., Isaacs, N., Horowitz, M., & Blackshaw, L. (2007). Phenotypic characterization of taste cells of the mouse small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(5), G1420-G1428. DOI Scopus115 WoS109 Europe PMC86
2005	Page, A., Slattery, J., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2005). Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret. Journal of Physiology-London, 563(3), 809-819. DOI Scopus33 WoS25 Europe PMC21
2005	Page, A., Young, R., Martin, C., Umaerus, M., O'Donnell, T., Isaacs, N., . . . Blackshaw, L. (2005). Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology, 128(2), 402-410. DOI Scopus86 WoS71 Europe PMC64
2001	Isaacs, N., McClean, R., Leigh, C., & Breed, W. (2001). Glycoconjugates on the surface of epididymal spermatozoa in a marsupial, the brushtail possum, Trichosurus vulpecula. Reproduction, 122(1), 165-176. DOI Scopus9 WoS8 Europe PMC5
2001	Smid, S., Young, R., Isaacs, N., & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281(6), G1494-G1501. DOI Scopus66 WoS48 Europe PMC35
1998	Cooper, N., Holland, M., & Breed, W. (1998). Extratesticular sperm maturation in the brush-tail possum, Trichosurus vulpecula. Journal of Reproduction and Fertility Supplement, 53, 221-226. Scopus5 WoS6 Europe PMC2
1998	Lamont, A., Clarke, H., Cooper, N., Holland, M., & Breed, W. (1998). Protein synthesis and secretion by the epididymis of the brushtail possum, Trichosurus vulpecula. Journal of Reproduction and Fertility, 114(1), 169-177. DOI Scopus6 WoS7 Europe PMC5

Book Chapters

Year	Citation
2003	Brierley, S., Coldwell, J., Isaacs, N., Howarth, G., & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, & N. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (Vol. 130, pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers.

Year

Citation

2003

Brierley, S., Coldwell, J., Isaacs, N., Howarth, G., & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, & N. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (Vol. 130, pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers.

Conference Papers

Year	Citation
2013	Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2012	Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2012	Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2009	Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V.. DOI
2002	Young, R. L., Cooper, N. J., & Blackshaw, L. A. (2002). Neurochemical coding of gastric vago-vagal pathways in the ferret. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS.

Conference Items

Year	Citation
2020	Kreuch, D., Ivey, K., Mobegi, F. M., Leong, L., Isaacs, N. J., Pezos, N., . . . Young, R. L. (2020). Mechanisms linking low-calorie sweeteners to impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 4th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2020), as published in Neurogastroenterology and Motility. Adelaide Convention Centre, Adelaide, Australia: Wiley. DOI
2018	Young, R. L., Kreuch, D., Mobegi, F. M., Leong, L., Schober, G., Isaacs, N. J., . . . Rogers, G. B. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2017	Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI WoS4
2012	Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders. DOI
2010	Isaacs, N., Flach, C., Young, R., Wittert, G., Blackshaw, L., & Page, A. (2010). Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice. Poster session presented at the meeting of Abstracts of the 111th Annual Meeting of the American-Gastroenterological-Association/Digestive Disease Week, as published in Gastroenterology. USA: W.B. Saunders Co.. DOI
2000	Isaacs, N., & Breed, W. (2000). Changes in glycoprotein composition of the plasma membrane of brushtail possum spermatozoa, during epidydmal migration. Poster session presented at the meeting of Program, Abstracts & Mini-posters incorporating the Proceedings of the Thirty-first Annual Conference of the Australian Society for Reproductive Biology - FSA/ASRB 2000. Canberra, Australia: Australian Society for Reproductive Biology.

Position: Senior Research Officer
Phone: 81284863
Email: nicole.isaacs@adelaide.edu.au
Campus: North Terrace
Building: SAHMRI, floor 7
Org Unit: Medical Specialties

Mrs Nicole Isaacs

Senior Research Officer and Clinical Trials Coordinator

Education

Certifications

Research Interests

Journals

Book Chapters

Conference Papers

Conference Items

Connect With Me

External Profiles