Nicole Isaacs

Research Interests

Animal Cell and Molecular Biology Animal Nutrition Biochemistry & Molecular Biology Biochemistry and Cell Biology Biological Sciences Cell Biology Clinical Sciences Clinical Trials Medical and Health Sciences Medical Bacteriology Medical Biochemistry and Metabolomics Microscopy Nutrition and Metabolic Health Translational Health Outcomes

Mrs Nicole Isaacs

Senior Research Officer

School of Medicine

College of Health

Senior Research Officer and Clinical Trials Coordinator

 

Date Institution name Country Title
1996 - 1997 University of Adelaide Australia Bachelor of Science (Hons)
1992 - 1996 University of Adelaide Australia Bachelor of Science

Date Title Institution name Country
— Certificate IV in Veterinary Nursing TAFE SA - Gilles Plains Campus Australia

Year Citation
2021 Sun, E. W., Iepsen, E. W., Pezos, N., Lumsden, A. L., Martin, A. M., Schober, G., . . . Keating, D. J. (2021). A gut-intrinsic melanocortin signalling complex augments L cell secretion in humans. Gastroenterology, 161(2), 536-547.
DOI Scopus13 WoS14 Europe PMC11
2019 Lumsden, A. L., Martin, A. M., Sun, E. W., Schober, G., Isaacs, N. J., Pezos, N., . . . Keating, D. J. (2019). Sugar responses of human enterochromaffin cells depend on gut region, sex, and body mass. Nutrients, 11(2), 1-13.
DOI Scopus23 WoS22 Europe PMC23
2018 Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889.
DOI Scopus79 WoS68 Europe PMC60
2017 Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans. Clinical Nutrition, 36(2), 1-6.
DOI Scopus16 WoS14 Europe PMC13
2017 Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. International Journal of Obesity, 41(2), 233-239.
DOI Scopus21 WoS21 Europe PMC20
2014 Little, T., Isaacs, N., Young, R., Ott, R., Nguyen, N., Rayner, C., . . . Feinle-Bisset, C. (2014). Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(10), G958-G967.
DOI Scopus49 WoS46 Europe PMC44
2013 Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A., . . . Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591(7), 1921-1934.
DOI Scopus77 WoS72 Europe PMC61
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2.
DOI Scopus38 WoS36 Europe PMC34
2013 Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T., . . . Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62(10), 3532-3541.
DOI Scopus94 WoS85 Europe PMC70
2013 Harrington, A., Brierley, S., Isaacs, N., Young, R., & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25(10), 660-668.
DOI Scopus20 WoS16 Europe PMC15
2013 Li, H., Kentish, S., Kritas, S., Young, R., Isaacs, N., O'Donnell, T., . . . Page, A. (2013). Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W. Acta Physiologica (Print Edition), 209(2), 179-191.
DOI Scopus20 WoS21 Europe PMC19
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465.
DOI Scopus183 WoS167 Europe PMC153
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255.
DOI Scopus62 WoS57 Europe PMC53
2012 Kentish, S., Li, H., Philp, L., O'Donnell, T., Isaacs, N., Young, R., . . . Page, A. (2012). Diet-induced adaptation of vagal afferent function. Journal of Physiology-London, 590(1), 209-221.
DOI Scopus119 WoS115 Europe PMC103
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468.
DOI Scopus135 WoS123 Europe PMC117
2010 Isaacs, N. J., Young, R. L., Wittert, G., Blackshaw, L. A., & Page, A. J. (2010). Anatomy of gastric vagal afferent innervation in normal and obese mice. NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9.
2010 Young, R., Page, A., Isaacs, N., Flach, C., & Blackshaw, L. (2010). Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves. Gastroenterology, 138(3), 1091-1106.
DOI Scopus56 WoS37 Europe PMC30
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095.
DOI Scopus242 WoS220 Europe PMC201
2009 Page, A., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2009). Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function. Journal of Neuroscience, 29(22), 7246-7255.
DOI Scopus41 WoS38 Europe PMC32
2008 Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N., . . . Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134(7), 2059-2069.
DOI Scopus231 WoS198 Europe PMC195
2008 Young, R., Isaacs, N., & Blackshaw, L. (2008). Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways. Neuropharmacology, 54(6), 965-975.
DOI Scopus24 WoS22 Europe PMC19
2008 Young, R., Isaacs, N., & Blackshaw, L. (2008). Chemical coding and central projections of gastric vagal afferent neurons. Neurogastroenterology and Motility, 20(6), 708-718.
DOI Scopus30 WoS24 Europe PMC23
2007 Young, R., Page, A., Isaacs, N., O'Donnell, T., & Blackshaw, L. (2007). Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G501-G511.
DOI Scopus39 WoS33 Europe PMC33
2007 Sutherland, K., Young, R., Isaacs, N., Horowitz, M., & Blackshaw, L. (2007). Phenotypic characterization of taste cells of the mouse small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(5), G1420-G1428.
DOI Scopus116 WoS113 Europe PMC103
2005 Page, A., Slattery, J., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2005). Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret. Journal of Physiology-London, 563(3), 809-819.
DOI Scopus33 WoS25 Europe PMC26
2005 Page, A., Young, R., Martin, C., Umaerus, M., O'Donnell, T., Isaacs, N., . . . Blackshaw, L. (2005). Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology, 128(2), 402-410.
DOI Scopus87 WoS73 Europe PMC70
2001 Isaacs, N., McClean, R., Leigh, C., & Breed, W. (2001). Glycoconjugates on the surface of epididymal spermatozoa in a marsupial, the brushtail possum, Trichosurus vulpecula. Reproduction, 122(1), 165-176.
DOI Scopus10 WoS9 Europe PMC7
2001 Smid, S., Young, R., Isaacs, N., & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281(6), G1494-G1501.
DOI Scopus67 WoS50 Europe PMC48
1998 Cooper, N., Holland, M., & Breed, W. (1998). Extratesticular sperm maturation in the brush-tail possum, Trichosurus vulpecula. Journal of Reproduction and Fertility Supplement, 53, 221-226.
Scopus5 WoS6 Europe PMC3
1998 Lamont, A., Clarke, H., Cooper, N., Holland, M., & Breed, W. (1998). Protein synthesis and secretion by the epididymis of the brushtail possum, Trichosurus vulpecula. Journal of Reproduction and Fertility, 114(1), 169-177.
DOI Scopus6 WoS7 Europe PMC5

Year Citation
2013 Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2012 Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2012 Harrington, A. M., Brierley, S. M., Castro, J., Isaacs, N. J., & Blackshaw, L. A. (2012). Characterization of Dorsal Horn Neurons Activated by Noxious Colorectal Distension in Health and Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S699). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V..
DOI
2002 Young, R. L., Cooper, N. J., & Blackshaw, L. A. (2002). Neurochemical coding of gastric vago-vagal pathways in the ferret. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS.

Year Citation
2020 Kreuch, D., Ivey, K., Mobegi, F. M., Leong, L., Isaacs, N. J., Pezos, N., . . . Young, R. L. (2020). Mechanisms linking low-calorie sweeteners to impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 4th Meeting of the Federation of Neurogastroenterology and Motility (FNM 2020), as published in Neurogastroenterology and Motility. Adelaide Convention Centre, Adelaide, Australia: Wiley.
DOI
2018 Young, R. L., Kreuch, D., Mobegi, F. M., Leong, L., Schober, G., Isaacs, N. J., . . . Rogers, G. B. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
DOI
2017 Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer.
DOI WoS4
2012 Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders.
DOI
2010 Isaacs, N., Flach, C., Young, R., Wittert, G., Blackshaw, L., & Page, A. (2010). Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice. Poster session presented at the meeting of Abstracts of the 111th Annual Meeting of the American-Gastroenterological-Association/Digestive Disease Week, as published in Gastroenterology. USA: W.B. Saunders Co..
DOI
2000 Isaacs, N., & Breed, W. (2000). Changes in glycoprotein composition of the plasma membrane of brushtail possum spermatozoa, during epidydmal migration. Poster session presented at the meeting of Program, Abstracts & Mini-posters incorporating the Proceedings of the Thirty-first Annual Conference of the Australian Society for Reproductive Biology - FSA/ASRB 2000. Canberra, Australia: Australian Society for Reproductive Biology.

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