Mrs Nicole Isaacs

Nicole Isaacs
Research Officer
Adelaide Medical School
Faculty of Health and Medical Sciences

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Mrs Nicole Isaacs

Clinical Research Coordinator │ Senior Research Assistant

Adelaide Medical School & NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health │The University of Adelaide

Intestinal Nutrient Sensing Group │ Centre for Nutrition & Gastrointestinal Diseases │ South Australian Health & Medical Research institute (SAHMRI)

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Nicole is Clinical Research Coordinator for A/Professor Richard L Young

There are a number of Clinical Trial’s underway requiring volunteers.

Students are also encouraged to enquire regarding Honours and Postdoctoral studies.

Please contact Nicole for more information.

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Clinical Studies currently underway (January 2017) ...

 

Study 1: Artificial Sweetener Study

Community based study involving healthy volunteers, looking at how signals in the intestine control the uptake of sugar into the body, and whether these pathways are altered by diet supplementation with artificial sweeteners.

Artificial Sweetener Study

 

Study 3: Sweet Taste Study - Diabetes Clinical Trial

The aim of this research is to understand how the gut senses sugars, and then regulates the uptake of sugar into the blood steam in people with Type 2 Diabetes.

Sweet Taste Study

Journals

Year Citation
2017 Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R. & Little, T. (2017). Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. International Journal of Obesity, 41, 2, 233-239.
10.1038/ijo.2016.199
2016 Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R. & Little, T. (2016). Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans. Clinical Nutrition, 36, 2, 1-6.
10.1016/j.clnu.2016.02.005
2014 Little, T., Isaacs, N., Young, R., Ott, R., Nguyen, N., Rayner, C. ... Feinle-Bisset, C. (2014). Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307, 10, G958-G967.
10.1152/ajpgi.00134.2014
2013 Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A. ... Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591, 7, 1921-1934.
10.1113/jphysiol.2012.247577
2013 Li, H., Kentish, S., Kritas, S., Young, R., Isaacs, N., O'Donnell, T. ... Page, A. (2013). Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W. Acta Physiologica (Print Edition), 209, 2, 179-191.
10.1111/apha.12154
2013 Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D. ... Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62, 10, 1456-1465.
10.1136/gutjnl-2011-301856
2013 Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G. ... Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online, 7, 1-2.
10.1136/gutjnl-2013-306240
2013 Harrington, A., Brierley, S., Isaacs, N., Young, R. & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25, 10, 660-668.
10.1111/nmo.12180
2013 Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T. ... Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62, 10, 3532-3541.
10.2337/db13-0581
2012 Kentish, S., Li, H., Philp, L., O'Donnell, T., Isaacs, N., Young, R. ... Page, A. (2012). Diet-induced adaptation of vagal afferent function. Journal of Physiology-London, 590, 1, 209-221.
10.1113/jphysiol.2011.222158
2012 Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J. & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520, 10, 2241-2255.
10.1002/cne.23042
2011 Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N. ... Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152, 7, 1459-1468.
10.1016/j.pain.2011.01.027
2010 Isaacs, N., Young, R., Wittert, G., Blackshaw, L. & Page, A. (2010). Anatomy of gastric vagal afferent innervation in normal and obese mice. NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9-9.
2010 Young, R., Page, A., Isaacs, N., Flach, C. & Blackshaw, L. (2010). Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves. Gastroenterology, 138, 3, 1091-1106.
10.1053/j.gastro.2009.08.053
2009 Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T. ... Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137, 6, 2084-2095.
10.1053/j.gastro.2009.07.048
2009 Page, A., O'Donnell, T., Isaacs, N., Young, R. & Blackshaw, L. (2009). Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function. Journal of Neuroscience, 29, 22, 7246-7255.
10.1523/JNEUROSCI.6099-08.2009
2008 Young, R., Isaacs, N. & Blackshaw, L. (2008). Chemical coding and central projections of gastric vagal afferent neurons. Neurogastroenterology and Motility, 20, 6, 708-718.
10.1111/j.1365-2982.2007.01071.x
2008 Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N. ... Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134, 7, 2059-2069.
10.1053/j.gastro.2008.01.074
2008 Young, R., Isaacs, N. & Blackshaw, L. (2008). Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways. Neuropharmacology, 54, 6, 965-975.
10.1016/j.neuropharm.2008.02.010
2007 Young, R., Page, A., Isaacs, N., O'Donnell, T. & Blackshaw, L. (2007). Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, 2, G501-G511.
10.1152/ajpgi.00353.2006
2007 Sutherland, K., Young, R., Isaacs, N., Horowitz, M. & Blackshaw, L. (2007). Phenotypic characterization of taste cells of the mouse small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292, 5, G1420-G1428.
10.1152/ajpgi.00504.2006
2005 Page, A., Slattery, J., O'Donnell, T., Isaacs, N., Young, R. & Blackshaw, L. (2005). Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret. Journal of Physiology-London, 563, 3, 809-819.
10.1113/jphysiol.2004.075291
2005 Page, A., Young, R., Martin, C., Umaerus, M., O'Donnell, T., Isaacs, N. ... Blackshaw, L. (2005). Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology, 128, 2, 402-410.
10.1053/j.gastro.2004.11.062
2001 Isaacs, N., McClean, R., Leigh, C. & Breed, W. (2001). Glycoconjugates on the surface of epididymal spermatozoa in a marsupial, the brushtail possum, Trichosurus vulpecula. Reproduction, 122, 1, 165-176.
10.1530/rep.0.1220165
2001 Smid, S., Young, R., Isaacs, N. & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281, 6, G1494-G1501.

Book Chapters

Year Citation
2003 Brierley, S., Coldwell, J., Isaacs, N., Howarth, G. & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann & N. J. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers.

Conference Papers

Year Citation
2010 Isaacs, N., Flach, C., Young, R., Wittert, G., Blackshaw, L. & Page, A. (2010). Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice.
10.1016/S0016-5085(10)62805-3
2009 Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S. & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. Congress of the International Society for Autonomic Neuroscience - ISAN. Sydney, Australia.
10.1016/j.autneu.2009.05.028

Conference Items

Year Citation
2012 Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D. ... Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Digestive Disease Week. San Diego.
10.1016/S0016-5085(12)62702-4
2000 Isaacs, N. & Breed, W. (2000). Changes in glycoprotein composition of the plasma membrane of brushtail possum spermatozoa, during epidydmal migration. FSA/ASRB 2000 - Thirty-first Annual Conference of the Australian Society for Reproductive Biology. Canberra, Australia.
Position
Research Officer
Phone
81284863
Campus
North Terrace West
Building
SAHMRI
Room Number
7 South
Org Unit
Medical Specialties

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