Mrs Nicole Isaacs

Research Officer

Adelaide Medical School

Faculty of Health and Medical Sciences

My Research
Career
Publications
Contact

Clinical Research Coordinator │ Senior Research Assistant

Adelaide Medical School & NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health │The University of Adelaide

Intestinal Nutrient Sensing Group │ Centre for Nutrition & Gastrointestinal Diseases │ South Australian Health & Medical Research institute (SAHMRI)

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Nicole is a Senior Research Officer and the Clinical Research Coordinator for A/Professor Richard L Young

If you are a student interested in projects available for Honours and Postdoctoral studies, please contact either Nicole or A/Prof Richard Young for more information.

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Clinical Studies currently underway (from October 2018) ...

Please contact Nicole 8128 8463 or taste_gut@adelaide.edu.au if you are interested in volunteering your time for clinical research trials.

Sweet Taste Study - Diabetes Clinical Trial

Bookings available until December 2018

Sweet Taste Study

Type 2 Diabetic Artificial Sweetener Study

Bookings available from November 2018 onwards

Type 2 Diabetes Artificial Sweetener Study Flyer

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Education

Date Institution name Country Title
1996 - 1997 University of Adelaide Australia Bachelor of Science (Hons)
1992 - 1996 University of Adelaide Australia Bachelor of Science
Certifications

Date Title Institution name Country
0 Certificate IV in Veterinary Nursing TAFE SA - Gilles Plains Campus Australia
Research Interests

Animal Cell and Molecular Biology Animal Nutrition Biochemistry & Molecular Biology Biochemistry and Cell Biology Biological Sciences Cell Biology Clinical Sciences Clinical Trials Medical and Health Sciences Medical Bacteriology Medical Biochemistry and Metabolomics Microscopy Nutrition and Metabolic Health Translational Health Outcomes

Date	Institution name	Country	Title
1996 - 1997	University of Adelaide	Australia	Bachelor of Science (Hons)
1992 - 1996	University of Adelaide	Australia	Bachelor of Science

Date	Title	Institution name	Country
0	Certificate IV in Veterinary Nursing	TAFE SA - Gilles Plains Campus	Australia

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Journals

Year	Citation
2019	Lumsden, A., Martin, A., Sun, E., Schober, G., Isaacs, N., Pezos, N., . . . Keating, D. (2019). Sugar responses of human enterochromaffin cells depend on gut region, sex, and body mass. Nutrients, 11(2), 1-13. DOI
2018	Young, R., Lumsden, A., Martin, A., Schober, G., Pezos, N., Thazhath, S., . . . Keating, D. (2018). Augmented capacity for peripheral serotonin release in human obesity. International Journal of Obesity, 42(11), 1880-1889. DOI Scopus8 WoS8 Europe PMC6
2017	Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Duodenal fatty acid sensor and transporter expression following acute fat exposure in healthy lean humans. Clinical Nutrition, 36(2), 1-6. DOI Scopus11 WoS10 Europe PMC9
2017	Cvijanovic, N., Isaacs, N., Rayner, C., Feinle-Bisset, C., Young, R., & Little, T. (2017). Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. International Journal of Obesity, 41(2), 233-239. DOI Scopus5 WoS4 Europe PMC4
2014	Little, T., Isaacs, N., Young, R., Ott, R., Nguyen, N., Rayner, C., . . . Feinle-Bisset, C. (2014). Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. American Journal of Physiology. Gastrointestinal and Liver Physiology, 307(10), G958-G967. DOI Scopus25 WoS24 Europe PMC10
2013	Kentish, S., O'Donnell, T., Isaacs, N., Young, R., Li, H., Harrington, A., . . . Page, A. (2013). Gastric vagal afferent modulation by leptin is influenced by food intake status. Journal of Physiology-London, 591(7), 1921-1934. DOI Scopus43 WoS41 Europe PMC33
2013	Hughes, P., Castro Kraftchenko, J., Harrington, A., Isaacs, N., Moretta, M., Hicks, G., . . . Brierley, S. (2013). Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut, Online(7), 1-2. DOI Scopus27 WoS28 Europe PMC22
2013	Young, R., Chia, C., Isaacs, N., Ma, J., Khoo, J., Wu, T., . . . Rayner, C. (2013). Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes, 62(10), 3532-3541. DOI Scopus58 WoS51 Europe PMC39
2013	Harrington, A., Brierley, S., Isaacs, N., Young, R., & Blackshaw, L. (2013). Identifying spinal sensory pathways activated by noxious esophageal acid. Neurogastroenterology and Motility, 25(10), 660-668. DOI Scopus13 WoS12 Europe PMC7
2013	Li, H., Kentish, S., Kritas, S., Young, R., Isaacs, N., O'Donnell, T., . . . Page, A. (2013). Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W. Acta Physiologica (Print Edition), 209(2), 179-191. DOI Scopus15 WoS14 Europe PMC7
2013	Hughes, P., Harrington, A., Castro Kraftchenko, J., Liebregts, T., Adam, B., Grasby, D., . . . Brierley, S. (2013). Sensory neuro-immune interactions differ between Irritable Bowel Syndrome subtypes. Gut, 62(10), 1456-1465. DOI Scopus112 WoS106 Europe PMC83
2012	Harrington, A., Brierley, S., Isaacs, N., Hughes, P., Castro Kraftchenko, J., & Blackshaw, L. (2012). Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity. Journal of Comparative Neurology, 520(10), 2241-2255. DOI Scopus34 WoS36 Europe PMC23
2012	Kentish, S., Li, H., Philp, L., O'Donnell, T., Isaacs, N., Young, R., . . . Page, A. (2012). Diet-induced adaptation of vagal afferent function. Journal of Physiology-London, 590(1), 209-221. DOI Scopus65 WoS64 Europe PMC45
2011	Harrington, A., Hughes, P., Martin, C., Yang, J., Castro, J., Isaacs, N., . . . Brierley, S. (2011). A novel role for TRPM8 in visceral afferent function. PAIN®, 152(7), 1459-1468. DOI Scopus83 WoS75 Europe PMC64
2010	Isaacs, N., Young, R., Wittert, G., Blackshaw, L., & Page, A. (2010). Anatomy of gastric vagal afferent innervation in normal and obese mice. NEUROGASTROENTEROLOGY AND MOTILITY, 22, 9.
2010	Young, R., Page, A., Isaacs, N., Flach, C., & Blackshaw, L. (2010). Sensory and Motor Innervation of the Crural Diaphragm by the Vagus Nerves. Gastroenterology, 138(3), 1091-1106. DOI Scopus34 WoS22 Europe PMC13
2009	Brierley, S., Hughes, P., Page, A., Kwan, K., Martin, C., O'Donnell, T., . . . Blackshaw, L. (2009). The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology, 137(6), 2084-2095. DOI Scopus178 WoS171 Europe PMC133
2009	Page, A., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2009). Nitric Oxide as an Endogenous Peripheral Modulator of Visceral Sensory Neuronal Function. Journal of Neuroscience, 29(22), 7246-7255. DOI Scopus26 WoS24 Europe PMC22
2008	Brierley, S., Page, A., Hughes, P., Adam, B., Liebregts, T., Isaacs, N., . . . Blackshaw, L. (2008). Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology, 134(7), 2059-2069. DOI Scopus175 WoS155 Europe PMC127
2008	Young, R., Isaacs, N., & Blackshaw, L. (2008). Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways. Neuropharmacology, 54(6), 965-975. DOI Scopus21 WoS19 Europe PMC12
2008	Young, R., Isaacs, N., & Blackshaw, L. (2008). Chemical coding and central projections of gastric vagal afferent neurons. Neurogastroenterology and Motility, 20(6), 708-718. DOI Scopus24 WoS19 Europe PMC16
2007	Young, R., Page, A., Isaacs, N., O'Donnell, T., & Blackshaw, L. (2007). Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G501-G511. DOI Scopus37 WoS30 Europe PMC24
2007	Sutherland, K., Young, R., Isaacs, N., Horowitz, M., & Blackshaw, L. (2007). Phenotypic characterization of taste cells of the mouse small intestine. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(5), G1420-G1428. DOI Scopus101 WoS98 Europe PMC71
2005	Page, A., Slattery, J., O'Donnell, T., Isaacs, N., Young, R., & Blackshaw, L. (2005). Modulation of gastro-oesophageal vagal afferents by galanin in mouse and ferret. Journal of Physiology-London, 563(3), 809-819. DOI Scopus24 WoS21 Europe PMC17
2005	Page, A., Young, R., Martin, C., Umaerus, M., O'Donnell, T., Isaacs, N., . . . Blackshaw, L. (2005). Metabotropic glutamate receptors inhibit mechanosensitivity in vagal sensory neurons. Gastroenterology, 128(2), 402-410. DOI Scopus79 WoS68 Europe PMC58
2001	Isaacs, N., McClean, R., Leigh, C., & Breed, W. (2001). Glycoconjugates on the surface of epididymal spermatozoa in a marsupial, the brushtail possum, Trichosurus vulpecula. Reproduction, 122(1), 165-176. DOI Scopus8 WoS7 Europe PMC5
2001	Smid, S., Young, R., Isaacs, N., & Blackshaw, L. (2001). GABABR expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. American Journal of Physiology - Gastrointestinal and Liver Physiology, 281(6), G1494-G1501. DOI Scopus56 WoS43 Europe PMC29

Book Chapters

Year	Citation
2003	Brierley, S., Coldwell, J., Isaacs, N., Howarth, G., & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, & N. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (Vol. 130, pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers.

Year

Citation

2003

Brierley, S., Coldwell, J., Isaacs, N., Howarth, G., & Blackshaw, L. (2003). Colonic spinal primary afferents: mechanosensory and chemosensory subtypes and effects of inflammation. In G. Holtmann, & N. Talley (Eds.), Falk Symposium 130 - Gastrointestinal inflammation and disturbed gut function - the challenge of new concepts (Vol. 130, pp. 120-125). PO Box 17, 3300AA Dordrecht, The Netherlands: Kluwer Academic Publishers.

Conference Papers

Year	Citation
2013	Hughes, P. A., Harrington, A. M., Castro, J., Isaacs, N. J., Moretta, M., Hicks, G. A., . . . Brierley, S. M. (2013). Increased Efficacy of the Peripherally-Restricted Selective Kappa-Opioid Receptor Agonist, Asimadoline, in Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 144 (pp. S934-S935). Orlando, FL: W B SAUNDERS CO-ELSEVIER INC.
2012	Hughes, P. A., Isaacs, N. J., Moretta, M., Hicks, G. A., Urso, D. M., Blackshaw, L. A., & Brierley, S. M. (2012). Identification of Kappa Opioid Receptors on Colonic Sensory Nerves and Their Up-Regulation in a Mouse Model of Chronic Visceral Hypersensitivity. In GASTROENTEROLOGY Vol. 142 (pp. S702). San Diego, CA: W B SAUNDERS CO-ELSEVIER INC.
2010	Isaacs, N., Flach, C., Young, R., Wittert, G., Blackshaw, L., & Page, A. (2010). Anatomy of gastric vagal afferent-leptin interactions in normal and obese mice. In Proceedings Vol. 138 (pp. 0 pages). USA: W.B. Saunders Co.. DOI
2009	Harrington, A., Hughes, P., Martin, C., Isaacs, N., Brierley, S., & Blackshaw, L. (2009). Localisation and function of transient receptor potential ion channel melastatin subtype 8 (TRPM8) in mouse colonic primary afferent nerve fibers. In Autonomic neuroscience Vol. 149 (pp. 29). United States: Elsevier B.V.. DOI
2002	Young, R., Cooper, N., & Blackshaw, L. (2002). Neurochemical coding of gastric vago-vagal pathways in the ferret. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 543 (pp. 5P). UNIV LIVERPOOL, LIVERPOOL, ENGLAND: CAMBRIDGE UNIV PRESS.

Conference Items

Year	Citation
2018	Young, R., Kreuch, D., Mobegi, F., Leong, L., Schober, G., Isaacs, N., . . . Rogers, G. (2018). Low-calorie sweeteners disrupt the gut microbiome in healthy subjects in association with impaired glycaemic control. Poster session presented at the meeting of Abstracts of the 54th Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI
2017	Young, R., Isaacs, N., Schober, G., Wu, T., Cvijanovic, N., Pezos, N., . . . Horowitz, M. (2017). Impact of artificial sweeteners on glycaemic control in healthy humans. Poster session presented at the meeting of Abstracts of the 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD 2017), as published in Diabetologia. Berlin Heidelberg: Springer. DOI WoS1
2012	Hughes, P., Nicholson, I., Bird, D., To, S., Isaacs, N., Grasby, D., . . . Krumbiegel, D. (2012). C-IBS patients lack monocyte derived β-endorphin which results in disinhibition of colonic afferent mechanosensitivity. Poster session presented at the meeting of Gastroenterology. USA: WB Saunders. DOI
2000	Isaacs, N., & Breed, W. (2000). Changes in glycoprotein composition of the plasma membrane of brushtail possum spermatozoa, during epidydmal migration. Poster session presented at the meeting of Program, Abstracts & Mini-posters incorporating the Proceedings of the Thirty-first Annual Conference of the Australian Society for Reproductive Biology - FSA/ASRB 2000. Canberra, Australia: Australian Society for Reproductive Biology.

Position: Research Officer
Phone: 81284863
Email: nicole.isaacs@adelaide.edu.au
Campus: North Terrace
Building: SAHMRI, floor 7
Room: 7 South
Org Unit: Medical Specialties

Mrs Nicole Isaacs

Clinical Research Coordinator │ Senior Research Assistant

Clinical Studies currently underway (from October 2018) ...

Sweet Taste Study - Diabetes Clinical Trial

Type 2 Diabetic Artificial Sweetener Study

Education

Certifications

Research Interests

Journals

Book Chapters

Conference Papers

Conference Items

Connect With Me