Nicholas Eyre

Dr Nicholas Eyre

Postdoctoral Research Officer

School of Biological Sciences

Faculty of Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


I am a Molecular Virologist and Senior Post-doctoral Research Fellow in the Research Centre for Infectious Diseases (RCID) at the University of Adelaide. My research over the past 10 years has focussed on multiple aspects of virus-host interactions and viral genome replication for the related (+)RNA viruses hepatitis C virus (HCV), dengue virus (DENV) and, most recently, Zika virus (ZIKV). In particular I have sought to apply sensitive and minimally invasive high-resolution imaging techniques and targeted and random manipulation of viral genomes to better understand the viral and host determinants of viral replication compartment formation, morphology and function and how they interact with viral assembly platforms.

My research focuses on virus-host interactions and viral genome replication for the related (+)RNA viruses hepatitis C virus (HCV), dengue virus (DENV) and, most recently, Zika virus (ZIKV). In particular I have sought to apply novel reporter virus tools, sensitive and minimally invasive high-resolution imaging techniques and targeted and random manipulation of viral genomes to better understand the viral and host determinants of viral replication compartment formation, morphology and function and how they viral replication complexes interact with viral assembly platforms. It is hoped that identification of features of viral proteins and virus-host interactions that are essential for the viral replication cycle will identify targets for future antiviral drug development.  

2017: Robinson Research Institute (RRI) Innovation Seed Funding Program. Janokovic-Karasoulos T, Van der Hoek K, Jolly LA, Eyre NS. The impact of Zika virus infection on placenta and neural development during early gestation. $25,000.

2015: ARC Linkage Infrastructure, Equipment and Facilities (LIEF) LE150100163. Gaus K, Gooding J, Boecking T, Lee L, Whisstock J, Rossjohn J, Hertzog P, Heath W, Godfrey D, Hatters D, Quiney H, Abbey B, Braet F, King N, Grau G, van Oijen A, Goldys E, Mak J, Yap A, Meunier F, Eyre N, Russell S. Single molecule imaging laboratory. $560,000.

2015-2016: Promega – Technology Development Collaboration. Development of NanoBRET assays to measure protein-nucleic acid interactions. Eyre NS (CIA). $30,000 (in kind).

2013-2015: Australian Centre for HIV and Hepatitis Virology Research (ACH2) Expression of Interest Project Grant 2013-22 . Eyre NS (CIA), Aloia AL. Hepatitis C virus NS5A protein phosphorylation as a target for antiviral drug development. $120,000.

2012-2014: NHMRC Project Grant APP1027641. Beard MR, Eyre NS (CIB), Turville SG. Imaging the hepatitis C virus lifecycle in real-time. $461,325.

2011: Royal Adelaide Hospital Clinical Project Grant. Eyre NS (CIA; sole investigator). Isolation of a genotype 1 hepatitis C virus clone that can be efficiently propagated in cell culture. $25,000.

2011: School of Molecular and Biomedical Science (SMBS) Internal Funding Scheme Grant. Beard MR, Eyre NS (CIB). Understanding host viral interactions through live imaging of the HCV NS5A and core proteins. $22,500.

2008: Royal Adelaide Hospital Clinical Project Grant. Eyre NS (CIA; sole investigator). The involvement of PDZK1 in SR-BI-dependent entry of hepatitis C virus. $20,000.

2014-present:   Lecturer, Infection and Immunity (2nd year), University of Adelaide (2 lectures/year).

2014-present:   Lecturer, Infection and Immunity (3rd year), University of Adelaide (2 lectures/year).

2014-present:   Practical demonstrator, Microbiology and Immunology (3rd year), University of Adelaide (6 practicals/year).

2011-present:   Lecturer, Biomedical Science II (2nd year), University of Adelaide (2 lectures/year).

2012-2015:      Lecturer, Masters in Biotechnology, University of Adelaide (1 lecture/year).

2012-2015:      Tutor, Microbiology and Immunology (2nd year), University of Adelaide (3 tutorials/year).

2007-2008:      Tutor, Microbiology and Immunology (2nd year), University of Adelaide (3 tutorials/year).

2004-2005:      Tutor, Microbiology and Immunology (2nd year), University of Adelaide (8 tutorials/year).

2005:               Practical demonstrator, Microbiology and Immunology (3rd year), University of Adelaide (5 practicals/year).

2004-2005:      Practical demonstrator, School of Medicine (Microbiology component, 2nd year), University of Adelaide (7 practicals/year).

2004-2005:      Practical demonstrator, Engineering (Microbiology component, 2nd year), University of Adelaide (7 practicals/year).

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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor Genome-wide CRISPR Screens to Identify Novel Factors in Antiviral Innate Immunity Doctor of Philosophy Doctorate Full Time Miss Emily Nicole Kirby
    2019 Principal Supervisor Molecular Dissection of the Dengue Virus NS1 Protein Doctor of Philosophy Doctorate Full Time Mr Thomas Darcy Burton
    2018 Co-Supervisor Characterising the molecular interactions of flaviviruses with the type-I Interferon response Doctor of Philosophy Doctorate Full Time Ms Rosa Cedar Coldbeck-Shackley
    2017 Co-Supervisor Innate Immunity to Hepatitis B in a Liver Organoid Culture System Doctor of Philosophy Doctorate Full Time Dr Chuan Kok Lim
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2014 - 2015 Co-Supervisor The Bystander Effect in Hepatitis C Virus Infection: Cellular Interactions Between Infected Cells and Uninfected Cells Doctor of Philosophy Doctorate Full Time Ms Kate Rebecca Muller
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  • Memberships

    Date Role Membership Country
    2017 - ongoing Treasurer Australian Centre for Hepatitis Virology (ACHV) Australia
  • Position: Postdoctoral Research Officer
  • Phone: 83135399
  • Email: nicholas.eyre@adelaide.edu.au
  • Fax: 8313 7532
  • Campus: North Terrace
  • Building: Molecular Life Sciences, floor 3
  • Room: 3 34
  • Org Unit: Molecular and Biomedical Science

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