Natasha Harvey

Research Interests

Cancer Cell Biology Cardiovascular System & Hematology Developmental Genetics Genomics and transcriptomics Medical Genetics

Prof Natasha Harvey

Director, Centre for Cancer Biology

Centre for Cancer Biology

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Professor Natasha Harvey is Director of the Centre for Cancer Biology, an internationally recognised Medical Research Institute investigating the biology underpinning cancer and translating this knowledge to provide better outcomes for cancer patients. The Centre for Cancer Biology is a strong alliance between UniSA and SA Pathology, harnessing the strengths of both partners to chart the path from scientific discovery to clinical implementation.
Natasha received her PhD in cell and molecular biology from the University of Adelaide and undertook postdoctoral training in developmental biology at St Jude Children’s Research Hospital, USA. During her postdoctoral training, Natasha's studies focussed on embryonic lymphatic vascular development and in particular, defining the role of the homeobox transcription factor PROX1 in programming cell identity during development.
Natasha returned to Adelaide in 2005 to establish her independent research program at the Centre for Cancer Biology. Natasha’s work aims to understand how the lymphatic vasculature is constructed during development and how this process “goes wrong” in human pathologies including cancer, vascular malformations and lymphoedema. Her work in this field has been published in leading international journals including Nature Genetics, Blood, Development, The Journal of Clinical Investigation and Science Translational Medicine.

GATA2 is important for the development and maintenance of lymphatic vessel valves.

In collaboration with Professor Hamish Scott’s team at the Centre for Cancer Biology, we recently discovered that heritable mutations in the transcription factor GATA2 predispose carriers to lymphoedema and myelodysplasia syndrome (MDS)-acute myeloid leukaemia (AML) (Kazenwadel et al., Blood, 2012). This discovery revealed a key role for GATA2 in lymphatic vessels. We subsequently demonstrated that GATA2 is present at high levels in lymphatic vessel valves and that GATA2 regulates the expression of genes required for valve development. Our most recent work has established that GATA2 is required both to initiate the process of lymphatic vessel valve development and maintain the architecture of lymphatic vessel valves once they have formed (Kazenwadel et al., J Clin Invest, 2015). Our current work aims to define precisely how GATA2 regulates gene expression in the lymphatic vasculature to control valve development. Ultimately, our goals are: 1) To identify new therapeutic targets to which effective therapeutics for the treatment of lymphoedema could be designed. 2) To understand how valve endothelial cell identity is transcriptionally programmed and how this process could be manipulated to generate valves for therapeutic applications.

Regulation of vascular development by the ubiquitin ligase Nedd4.

Ubiquitination is a highly conserved process of protein modification that leads to the tagging of target proteins by one or more ubiquitin molecules. Ubiquitination can “flag” proteins for degradation, dictate their subcellular localisation and/or regulate protein trafficking through cellular compartments. As such, ubiquitination has crucial roles in regulating many signalling pathways and mis-regulation of this process is associated with numerous human pathologies. We have found that the ubiquitin ligase Nedd4 plays key roles in the growth and development of both blood vessels and lymphatic vessels. Our current work aims to dissect the endothelial cell autonomous versus non-autonomous roles of Nedd4 during vascular development and to define the signalling pathways regulated by Nedd4 that are important for vessel growth and remodelling.


Date Position Institution name
2021 - ongoing Director, Centre for Cancer Biology Adelaide University

Date Type Title Institution Name Country Amount
2025 Fellowship Fellow Australian Academy of Health and Medical Sciences Australian Academy of Health and Medical Sciences Australia -

Language Competency
English Can read, write, speak, understand spoken and peer review

Date Institution name Country Title
1993 - 1998 University of Adelaide Australia PhD
1989 - 1992 University of Adelaide Australia Bachelor of Science with Honours

Date Title Institution Country
2001 - 2005 Postdoctoral Research Associate St Jude Children's Research Institute United States

Year Citation
2024 Panara, V., Yu, H., Peng, D., Staxäng, K., Hodik, M., Filipek-Gorniok, B., . . . Koltowska, K. (2024). Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds. Development, 151(9), dev202525-1-dev202525-14.
DOI Scopus5 WoS5 Europe PMC6
2024 Williamson, A. E., Liyanage, S., Hassanshahi, M., Dona, M. S. I., Toledo-Flores, D., Tran, D. X. A., . . . Psaltis, P. J. (2024). Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta. Nature Communications, 15(1), 7097-1-7097-21.
DOI Scopus6 WoS8 Europe PMC6
2023 Kazenwadel, J., Venugopal, P., Oszmiana, A., Toubia, J., Arriola-Martinez, L., Panara, V., . . . Harvey, N. L. (2023). A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. Nature, 614(7947), 343-348.
DOI Scopus30 WoS30 Europe PMC29
2023 Chiang, I. K. N., Graus, M. S., Kirschnick, N., Davidson, T., Luu, W., Harwood, R., . . . Francois, M. (2023). The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO Journal, 42(5, article no. e109032), 1-23.
DOI Scopus8 WoS8 Europe PMC9
2023 Hogan, B. M., Kahn, M. L., & Harvey, N. L. (2023). No crops without seeds: the risks in declining support for fundamental research. Nature Cardiovascular Research, 2(3), 193-195.
DOI Scopus3 WoS4 Europe PMC4
2023 Zhou, Z., Ma, X., Lin, Y., Cheng, D., Bavi, N., Secker, G. A., . . . Cox, C. D. (2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science, 381(6659), 799-804.
DOI Scopus49 WoS50 Europe PMC58
2022 Chau, T. C. Y., Baek, S., Coxam, B., Skoczylas, R., Rondon-Galeano, M., Bower, N. I., . . . Hogan, B. M. (2022). Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Developmental Dynamics, 251(2), 336-349.
DOI Scopus3 WoS3 Europe PMC1
2022 Windley, S. P., Mayère, C., McGovern, A. E., Harvey, N. L., Nef, S., Schwarz, Q., . . . Wilhelm, D. (2022). Loss of NEDD4 causes complete XY gonadal sex reversal in mice. Cell Death and Disease, 13(1), 75-1-75-10.
DOI Scopus5 WoS5 Europe PMC7
2022 Byrne, A. B., Brouillard, P., Sutton, D. L., Kazenwadel, J., Montazaribarforoushi, S., Secker, G. A., . . . Harvey, N. L. (2022). Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema. Science Translational Medicine, 14(634), eabm4869-1-eabm4869-15.
DOI Scopus38 WoS29 Europe PMC31
2022 Lohraseb, I., McCarthy, P., Secker, G., Marchant, C., Wu, J., Ali, N., . . . Schwarz, Q. (2022). Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells. Nature Communications, 13(1), 1-18.
DOI Scopus5 WoS6 Europe PMC7
2021 Secker, G. A., & Harvey, N. L. (2021). Regulation of vegfr signalling in lymphatic vascular development and disease: an update. International Journal of Molecular Sciences, 22(14), 1-16.
DOI Scopus55 WoS48 Europe PMC40
2021 Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). GATA2 deficiency syndrome: a decade of discovery. Human Mutation, 42(11), 1399-1421.
DOI Scopus51 WoS44 Europe PMC41
2021 Cao, E., Watt, M. J., Nowell, C. J., Quach, T., Simpson, J. S., De Melo Ferreira, V., . . . Trevaskis, N. L. (2021). Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity. Nature Metabolism, 3(9), 1175-1188.
DOI Scopus89 WoS85 Europe PMC73
2021 Homan, C. C., Venugopal, P., Arts, P., Shahrin, N. H., Feurstein, S., Rawlings, L., . . . Hahn, C. N. (2021). Cover, Volume 42, Issue 11. Human Mutation, 42(11).
DOI
2021 Bastow, C. R., Bunting, M. D., Kara, E. E., McKenzie, D. R., Caon, A., Devi, S., . . . Comerford, I. (2021). Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Proceedings of the National Academy of Sciences of USA, 118(17), e2025763118-1-e2025763118-9.
DOI Scopus31 WoS29 Europe PMC28
2021 Francois, M., Oszmiana, A., & Harvey, N. L. (2021). When form meets function: the cells and signals that shape the lymphatic vasculature during development. Development, 148(11), 1-13.
DOI Scopus14 WoS13 Europe PMC12
2020 Betterman, K. L., Sutton, D. L., Secker, G. A., Kazenwadel, J., Oszmiana, A., Lim, L., . . . Harvey, N. L. (2020). Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. Journal of Clinical Investigation, 130(6), 3315-3328.
DOI Scopus52 WoS46 Europe PMC45
2020 Oliver, G., Kipnis, J., Randolph, G. J., & Harvey, N. L. (2020). The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease. Cell, 182(2), 270-296.
DOI Scopus507 WoS479 Europe PMC460
2019 Baek, S., Oh, T. G., Secker, G., Sutton, D. L., Okuda, K. S., Paterson, S., . . . Hogan, B. M. (2019). The alternative splicing regulator Nova2 constrains vascular Erk signaling to limit specification of the lymphatic lineage. Developmental Cell, 49(2), 279-292.e5.
DOI Scopus30 WoS30 Europe PMC30
2019 Grimm, L., Nakajima, H., Chaudhury, S., Bower, N. I., Okuda, K. S., Cox, A. G., . . . Hogan, B. M. (2019). Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. eLife, 8(e42881), e42881-1-e42881-22.
DOI Scopus33 WoS32 Europe PMC28
2019 Harvey, N. L. (2019). Lymphatic vessels as a stem cell niche. Science, 366(6470), 1193-1194.
DOI Scopus2 WoS1 Europe PMC2
2018 Lumb, R., Tata, M., Xu, X., Joyce, A., Marchant, C., Harvey, N., . . . Schwarz, Q. (2018). Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla. Development, 145(21), 62552-1-162552-8.
DOI Scopus26 WoS22 Europe PMC21
2018 Frye, M., Taddei, A., Dierkes, C., Martinez-Corral, I., Fielden, M., Ortsäter, H., . . . Mäkinen, T. (2018). Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nature Communications, 9(1), 1511-1-1511-16.
DOI Scopus135 WoS127 Europe PMC116
2018 Kazenwadel, J., & Harvey, N. L. (2018). Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis. Current Opinion in Immunology, 53, 81-87.
DOI Scopus24 WoS21 Europe PMC22
2018 Pichol-Thievend, C., Betterman, K. L., Liu, X., Ma, W., Skoczylas, R., Lesieur, E., . . . Francois, M. (2018). A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development, 145(10), dev160184-1-dev160184-14.
DOI Scopus65 WoS63 Europe PMC64
2017 Hughes, J., Dawson, R., Tea, M., McAninch, D., Piltz, S., Jackson, D., . . . Thomas, P. (2017). Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling. Scientific Reports, 7(1), 12618-1-12618-15.
DOI Scopus51 WoS47 Europe PMC45
2016 Wiszniak, S., Harvey, N., & Schwarz, Q. (2016). Cell autonomous roles of Nedd4 in craniofacial bone formation. Developmental Biology, 410(1), 98-107.
DOI Scopus22 WoS22 Europe PMC19
2016 Betterman, K. L., & Harvey, N. L. (2016). The lymphatic vasculature: development and role in shaping immunity. Immunological Reviews, 271(1), 276-292.
DOI Scopus63 WoS63 Europe PMC51
2016 Ebert, L. M., Tan, L. Y., Johan, M. Z., Min, K. K. M., Cockshell, M. P., Parham, K. A., . . . Bonder, C. S. (2016). A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis. Angiogenesis, 19(4), 463-486.
DOI Scopus38 WoS39 Europe PMC30
2016 Kazenwadel, J., & Harvey, N. (2016). Morphogenesis of the lymphatic vasculature: a focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels. Developmental Dynamics, 245(3), 209-219.
DOI Scopus31 WoS29 Europe PMC23
2015 Kazenwadel, J., Betterman, K., Chong, C., Stokes, P., Lee, Y., Secker, G., . . . Harvey, N. (2015). GATA2 is required for lymphatic vessel valve development and maintenance. Journal of Clinical Investigation, 125(8), 2979-2994.
DOI Scopus193 WoS175 Europe PMC156
2015 Secker, G. A., & Harvey, N. L. (2015). VEGFR signaling during lymphatic vascular development : from progenitor cells to functional vessels. Developmental Dynamics, 244(3), 323-331.
DOI Scopus97 WoS92 Europe PMC86
2015 Angeli, V., & Harvey, N. L. (2015). Lymphatic vessels at the heart of the matter. Cell Metabolism, 22(1), 56-58.
DOI Scopus5 WoS4 Europe PMC4
2014 Lumb, R., Wiszniak, S., Kabbara, S., Scherer, M., Harvey, N., & Schwarz, Q. (2014). Neuropilins define distinct populations of neural crest cells. Neural Development, 9(1), 24-1-24-14.
DOI Scopus21 WoS20 Europe PMC21
2014 Betterman, K. L., & Harvey, N. L. (2014). Decoys and cardiovascular development: CXCR7 and regulation of adrenomedullin signaling. Developmental cell, 30(5), 490-491.
DOI Scopus9 WoS9 Europe PMC8
2014 Coxam, B., Sabine, A., Bower, N., Smith, K., Pichol-Thievend, C., Skoczylas, R., . . . Hogan, B. (2014). Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Reports, 7(3), 623-633.
DOI Scopus76 WoS75 Europe PMC72
2014 Kartopawiro, J., Bower, N., Karnezis, T., Kazenwadel, J., Betterman, K., Lesieur, E., . . . Hogan, B. (2014). Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, 23(5), 1286-1297.
DOI Scopus27 WoS26 Europe PMC27
2014 Bowles, J., Secker, G., Nguyen, C., Kazenwadel, J., Truong, V., Frampton, E., . . . Francois, M. (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386(1), 25-33.
DOI Scopus38 WoS34 Europe PMC35
2013 Wiszniak, S., Kabbara, S., Lumb, R., Scherer, M., Secker, G., Harvey, N., . . . Schwarz, Q. (2013). The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Developmental Biology, 383(2), 186-200.
DOI Scopus25 WoS28 Europe PMC29
2013 Koltowska, K., Betterman, K., Harvey, N., & Hogan, B. (2013). Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature. Development, 140(9), 1857-1870.
DOI Scopus115 WoS111 Europe PMC103
2013 Harvey, N. (2013). Lymphatic mispatterning. Australian Life Scientist, 10(5), 24-25.
2012 Westmoreland, J. J., KILIC, G., Sartain, C., Sirma, S., Blain, J., Rehg, J., . . . Sosa Pineda, B. (2012). Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology, 142(4), 999-1009.
DOI Scopus40 WoS37 Europe PMC32
2012 Betterman, K., Paquet- Fifield, S., Asselin-Labat, M., Visvader, J., Butler, L., Stacker, S., . . . Harvey, N. (2012). Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli. American Journal of Pathology, 181(6), 2225-2238.
DOI Scopus17 WoS16 Europe PMC15
2012 Kazenwadel, J., Secker, G., Betterman, K., & Harvey, N. (2012). In Vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis. PLoS One, 7(7), 1-12.
DOI Scopus38 WoS35 Europe PMC38
2012 Debrincat, M., Josefsson, E., James, C., Henley, K., Ellis, S., Lebois, M., . . . Kile, B. (2012). Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival. Blood, 119(24), 5850-5858.
DOI Scopus73 WoS67 Europe PMC65
2012 Francois, M., Short, K., Secker, G., Combes, A., Schwarz, Q., Davidson, T., . . . Koopman, P. (2012). Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Developmental Biology, 364(2), 89-98.
DOI Scopus76 WoS73 Europe PMC63
2012 Kazenwadel, J., Secker, G., Liu, Y., Rosenfeld, J., Wildin, R., Cuellar-Rodriguez, J., . . . Harvey, N. (2012). Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature. Blood, 119(5), 1283-1291.
DOI Scopus245 WoS217 Europe PMC204
2012 Harvey, N., & Gordon, E. (2012). Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Vascular Cell, 4(15), 15-1-15-7.
DOI Scopus56 WoS55 Europe PMC51
2011 Harvey, N. L. (2011). To sprout or "Notch" to sprout?. Blood, 118(4), 836-837.
DOI Scopus1 WoS1 Europe PMC1
2011 Francois, M., Harvey, N., & Hogan, B. (2011). The transcriptional control of lymphatic vascular development. Physiology, 26(3), 146-155.
DOI Scopus53 WoS44 Europe PMC39
2011 Gordon, E. J., Rao, S., Pollard, J. W., Nutt, S. L., Lang, R. A., & Harvey, N. L. (2011). Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation (Development 137, (3899-3910)). Development, 138(4), 797.
DOI Scopus1 WoS1
2010 Gordon, E., Rao, S., Pollard, J., Nutt, S., Lang, R., & Harvey, N. (2010). Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development, 137(22), 3899-3910.
DOI Scopus124 WoS118 Europe PMC116
2010 Kazenwadel, J., Michael, M., & Harvey, N. (2010). Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood, 116(13), 2395-2401.
DOI Scopus140 WoS138 Europe PMC130
2010 Fritzsch, B., Dillard, M., Lavado, A., Harvey, N., & Israt, J. (2010). Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS One, 5(2), 1-12.
DOI Scopus69 WoS63 Europe PMC64
2009 Risebro, C., Searles, R., Melville, A., Ehler, E., Jina, N., Shah, S., . . . Riley, P. (2009). Prox1 maintains muscle structure and growth in the developing heart. Development, 136(3), 495-505.
DOI Scopus112 WoS105 Europe PMC98
2009 Risebro, C. A., Searles, R. G., Melville, A. A. D., Ehler, E., Jina, N., Shah, S., . . . Riley, P. R. (2009). Erratum: Prox1 maintains muscle structure and growth in the developing heart (Development (2008) vol. 136 (495-505)). Development, 136(4), 699.
DOI Scopus1 WoS2
2008 Harvey, N. (2008). The link between lymphatic function and adipose biology. Annals of the New York Academy of Sciences, 1131(1), 82-88.
DOI Scopus88 WoS80 Europe PMC72
2008 Gordon, E., Gale, N., & Harvey, N. (2008). Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Developmental Dynamics, 237(7), 1901-1909.
DOI Scopus103 WoS99 Europe PMC90
2008 Smith, I., Harvey, N., Logan, R., David, D., & Anderson, P. (2008). Odontogenic keratocyst in a 5-year-old child: a rare cause of maxillary swelling in children. Journal of Plastic, Reconstructive & Aesthetic Surgery, 61(2), 189-191.
DOI Scopus4 WoS4 Europe PMC2
2008 Johnson, N. C., Dillard, M. E., Baluk, P., McDonald, D. M., Harvey, N. L., Frase, S. L., & Oliver, G. (2008). Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. GENES & DEVELOPMENT, 22(23), 3282-3291.
DOI Scopus289 WoS276 Europe PMC263
2008 Piller, N., Damstra, R., Cordero, I. F., Harvey, N. L., & Pond, C. (2008). Lymphatic system function and obesity - are there links?. Journal of Lymphoedema, 3(1), 81-85.
2006 Alva, J. A., Zovein, A. C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N. L., . . . Iruela-Arispe, M. L. (2006). VE-cadherin-cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Developmental Dynamics, 235(3), 759-767.
DOI Scopus382 WoS367 Europe PMC376
2005 Harvey, N. L., Srinivasan, R. S., Dillard, M. E., Johnson, N. C., Witte, M. H., Boyd, K., . . . Oliver, G. (2005). Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nature Genetics, 37(10), 1072-1081.
DOI Scopus501 WoS454 Europe PMC421
2005 Harvey, N. L. (2005). Embryonic lymphatic development: Recent advances and unanswered questions. Lymphatic Research and Biology, 3(3), 157-165.
DOI Scopus4 Europe PMC3
2004 Harvey, N. L., & Oliver, G. (2004). Choose your fate: Artery, vein or lymphatic vessel?. Current Opinion in Genetics and Development, 14(5), 499-505.
DOI Scopus36 WoS32 Europe PMC30
2003 Hirakawa, S., Hong, Y. K., Harvey, N., Schacht, V., Matsuda, K., Libermann, T., & Detmar, M. (2003). Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. American Journal of Pathology, 162(2), 575-586.
DOI Scopus404 WoS371 Europe PMC333
2003 Schacht, V., Ramirez, M. I., Hong, Y. K., Hirakawa, S., Feng, D., Harvey, N., . . . Detmar, M. (2003). T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO Journal, 22(14), 3546-3556.
DOI Scopus599 WoS550 Europe PMC497
2002 Hong, Y. K., Harvey, N., Noh, Y. H., Schacht, V., Hirakawa, S., Detmar, M., & Oliver, G. (2002). Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Developmental Dynamics, 225(3), 351-357.
DOI Scopus470 WoS436 Europe PMC388
2002 Wigle, J. T., Harvey, N., Detmar, M., Lagutina, I., Grosveld, G., Gunn, M. D., . . . Oliver, G. (2002). An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO Journal, 21(7), 1505-1513.
DOI Scopus812 WoS742 Europe PMC702
2002 O'Reilly, L., Ekert, P., Harvey, N., Marsden, V., Cullen, L., Vaux, D., . . . Kumar, S. (2002). Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death and Differentiation, 9(8), 832-841.
DOI Scopus167 WoS159 Europe PMC149
2001 Harvey, N., Daish, T., Mills, K., Dorstyn, L., Quinn, L., Read, S., . . . Kumar, S. (2001). Characterization of the Drosophila caspase, DAMM. Journal of Biological Chemistry, 276(27), 25342-25350.
DOI Scopus76 WoS67 Europe PMC64
2000 Shearwin-Whyatt, L., Harvey, N., & Kumar, S. (2000). Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death and Differentiation, 7(2), 155-165.
DOI Scopus51 WoS49 Europe PMC48
1998 Colussi, P., Harvey, N., & Kumar, S. (1998). Prodomain-dependent neclear localisation of the caspase-2 (Nedd2) precursor: A novel fuction for a caspase prodomain. Journal of Biological Chemistry, 273(38), 24535-24542.
DOI Scopus143 WoS138 Europe PMC127
1998 Butt, A., Harvey, N., Parasivam, G., & Kumar, S. (1998). Dimerization and auto processing of the Nedd2 (caspase 2) precursor requires both the prodomain and the carboxyl-terminal regions. Journal of Biological Chemistry, 273(12), 6763-6768.
DOI Scopus100 WoS98 Europe PMC89
1998 Colussi, P., Harvey, N., Shearwin-Whyatt, L., & Kumar, S. (1998). Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 predomain. Journal of Biological Chemistry, 273(41), 26566-26570.
DOI Scopus72 WoS70 Europe PMC60
1998 Harvey, K., Harvey, N., Michael, J., Parasivam, G., Waterhouse, N., Alnemri, E., . . . Kumar, S. (1998). Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis. Journal of Biological Chemistry, 273(22), 13524-13530.
DOI Scopus63 WoS64 Europe PMC52
1998 Harvey, N. L., & Kumar, S. (1998). The role of caspases in apoptosis.. Advances in Biochemical Engineering Biotechnology, 62, 107-128.
DOI Scopus48 Europe PMC30
1997 Harvey, N. L., Butt, A. J., & Kumar, S. (1997). Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis. Journal of Biological Chemistry, 272(20), 13134-13139.
DOI Scopus122 WoS127 Europe PMC101
1996 Harvey, N., Trapani, J., Fernandes-Alnemri, T., Litwack, G., Alnemri, E., & Kumar, S. (1996). Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes to Cells, 1(7), 673-686.
DOI Scopus54 WoS57 Europe PMC44
1996 Cole, S. R., Avlett, G. W., Casey, G., Harvey, N. L., Cambareri, A. C., & Ashman, L. K. (1996). Increased expression of c-Kit or its ligand Steel Factor is not a common feature of adult acute myeloid leukaemia. Leukemia, 10(2), 288-296.
Scopus35 WoS36 Europe PMC20
1995 Kumar, S., & Harvey, N. (1995). Role of multiple cellular proteases in the execution of programmed cell death. FEBS Letters, 375(3), 169-173.
DOI Scopus150 WoS149 Europe PMC99

Year Citation
2002 Oliver, G., & Harvey, N. (2002). A stepwise model of the development of lymphatic vasculature. In S. G. Rockson (Ed.), Annals of the New York Academy of Sciences Vol. 979 (pp. 159-165). NIH NATCHER CTR, BETHESDA, MD: NEW YORK ACAD SCIENCES.
DOI Scopus53 WoS47 Europe PMC42

Year Citation
2025 Wiszniak, S., Alankarage, D., Lohraseb, I., Marchant, C., Secker, G., Parker, W., . . . Schwarz, Q. (2025). Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development.
DOI

  • Centre of Research Excellence in Lymphoedema and Lymphatic Regeneration, NHMRC - Centre of Research Excellence, 12/09/2025 - 12/09/2030

  • Hippo signalling control of transcription in lymphatic vascular development, ARC - Discovery Projects, 01/01/2024 - 31/12/2026

  • Defining a new player in atherosclerosis: The role of Adventitial Haemangioblasts as an “outside-in” driver of plaque growth and stability, NHMRC - Ideas Grants, 01/07/2021 - 30/06/2024

  • Defining how molecular switches program cell identity during development, ARC - Discovery Projects, 01/03/2021 - 29/02/2024

  • Understanding the role of tissue growth pathways in expansion of the lymphatic vasculature, NHMRC - Project Grant, 01/01/2019 - 31/12/2022

  • Understanding the role of the atypical cadherin Fat4 in lymphatic vascular development, NHMRC - Project Grant, 01/01/2018 - 31/12/2021

  • Trafficking mechanisms governing receptor availability for signalling, NHMRC - Project Grant, 01/01/2018 - 31/12/2021

  • Defining the role of a novel transcriptional enhancer element in regulation of Prox1 expression and endothelial cell identity., NHMRC - Project Grant, 01/01/2018 - 31/12/2020

  • Understanding how GATA2 controls lymphatic vessel valve development, NHMRC - Project Grant, 01/01/2018 - 31/12/2020

  • Deciphering the transcriptional program that instructs lymphatic endothelial cell fate., NHMRC - Project Grant, 01/01/2016 - 31/12/2018

  • Regulation of VEGFR trafficking and signal transduction by the ubiquitin ligase Nedd4, NHMRC - Project Grant, 01/01/2015 - 31/12/2017

  • Defining the earliest events in lymphatic vasculature formation from veins, ARC - Discovery Projects, 01/01/2015 - 31/12/2017

  • The transcriptional control of lymphatic vessel development., ARC - Future Fellowship, 05/03/2014 - 31/12/2017

Date Role Research Topic Program Degree Type Student Load Student Name
2023 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Miss Ushani Mallawa Arachchige
2022 Principal Supervisor - Doctor of Philosophy Doctorate Full Time Mr Ivan Ngui

Date Role Research Topic Program Degree Type Student Load Student Name
2020 - 2023 External Supervisor Defining The Role of a Novel Gene “MyoD Family Inhibitor Domain Containing (MDFIC)” Important in Cardiovascular Development Doctor of Philosophy Doctorate Full Time Ms Saba Montazaribarforoushi
2012 - 2017 Co-Supervisor Mouse Mast Cell Protease 4 Protects Against Ultra Violet-B Induced Skin Tumourigenesis Doctor of Philosophy Doctorate Part Time Houng Huy Taing
2012 - 2022 External Supervisor Redefining neural crest cell heterogeneity through the analysis of Neuropilins Doctor of Philosophy Doctorate Full Time Miss Rachael Lumb
2008 - 2011 Principal Supervisor Investigating Lymphatic Vascular Remodelling During Postnatal Mouse Mammary Gland Morphogenesis Doctor of Philosophy Doctorate Full Time Ms Kelly Louise Betterman
2007 - 2011 Principal Supervisor Defining the role of myeloid cells in the regulation of developmental, tumour and inflammation-stimulated lymphangiogenesis Doctor of Philosophy Doctorate Full Time Ms Emma Gordon

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