Natalya Plakhova

Higher Degree by Research Candidate

School of Biomedicine

Faculty of Health and Medical Sciences

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PhD candidate (Medical Science) student currently working at SAHMRI (South Australian Health and Medical Research Institute) in the Multiple Myeloma Research Laboratory.

Natalya's PhD project focuses on the role of the ageing bone marrow in promoting the transition from indolent monoclonal gammopathy of undetermined significance (MGUS) to overt MM.

Ageing represents a significant risk factor for progression from asymptomatic MGUS to active MM, suggesting that age-related cellular changes may promote MM cell proliferation and progression to MM. She is investigating whether stromal cell senescence leads to increased proliferation of clonal MM cells, resulting in the outgrowth of malignant clones and progression to active MM.

Journals

Year	Citation
2023	Plakhova, N., Panagopoulos, V., Vandyke, K., Zannettino, A. C. W., & Mrozik, K. M. (2023). Mesenchymal stromal cell senescence in haematological malignancies. Cancer and Metastasis Reviews, 42(1), 1-20. DOI
2020	Clark, K. C., Hewett, D. R., Panagopoulos, V., Plakhova, N., Opperman, K. S., Bradey, A. L., . . . Zannettino, A. C. W. (2020). Targeted disruption of bone marrow stromal cell-derived Gremlin1 limits multiple myeloma disease progression in vivo. Cancers, 12(8), 2149-1-2149-20. DOI Scopus3 WoS3 Europe PMC1

Tutor for Human Anatomy and Physiology IA

Demonstrator for Human Anatomy and Physiology IA

Email: natalya.plakhova@adelaide.edu.au

Natalya Plakhova

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