Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Natalie Aboustate - Postdoctoral Researcher
Adelaide Medical School, Faculty of Health and Medical Sciences.
Major Research Themes
Perinatal Mental Health
Iron Metabolism in Pregnancy
Cognitive Function in Major Depressive Disorder
My research under the School of Psychiatry encompasses a multidisciplinary approach to personalised psychiatry under Prof Bernhard Baune. This research includes cognitive dysfunction in Major Depressive Disorder, the coordination of clinical trials for treatment resistant depression and genetic markers of inflammation associated with psychiatric disease.
Working under A/ Prof Bernd Froessler, I am coordinating the Protective Trial for Ferric Carboxymaltose infusions for women who suffer from iron deficiency during pregnancy. We are investigating pregnancy outcomes and perinatal mental health in this population to better characterise the effects of maternal iron deficiency on the mother and neonate, and how iron supplementation may ameliorate adverse outcomes.
My PhD characterised alterations in immune regulation by preterm neonates compared to term as they are particularly vulnerable to inflammatory morbidities and poor health outcomes. My research utilised placenta and cord blood as indicators of innate immune function in the preterm neonate, alongside data concerning clinical outcomes for these neonates. My findings showed preterm neonates can mount a robust response to inflammatory stimuli, but are unable to appropriately regulate inflammation. As preterm neonates are susceptible to contracting infections, attenuated immune regulation could underlie their susceptibility towards developing systemic inflammatory signalling.
Date Position Institution name 2018 Study Coordinator LMH, University of Adelaide 2018 - 2018 Tutor Flinders University 2017 Research Assistant University of Adelaide 2016 Research Assistant LMH, University of Adelaide 2012 - 2013 Research Assistant University of Adelaide
Language Competency English Can read, write, speak, understand spoken and peer review Italian Can read and understand spoken Polish Can read, speak and understand spoken
Date Institution name Country Title 2013 - 2018 University of Adelaide Australia PhD in Medicine 2012 - 2012 University of Adelaide Australia Honours in Health Sciences — University of Adelaide Australia Bachelor of Science
Date Title Institution name Country 2018 Venepuncture and phlebotomy SA Health Australia 2018 The C-SSRS Training – English-International - V.1. Research Foundation for Mental Hygiene — 0 Mental Health First Aid Mental Health First Aid Australia Australia 0 ICH E6 GCP Training INCR Clinical Education —
Year Citation 2018 Knight, M., Fourrier, C., Lyrtzis, E., Aboustate, N., Sampson, E., Hori, H., . . . Baune, B. (2018). Cognitive Deficits in the THINC-Integrated Tool (THINC-it) Are Associated With Psychosocial Dysfunction in Patients With Major Depressive Disorder. The Journal of clinical psychiatry, 80(1).
2018 Knight, M. J., Aboustate, N., & Baune, B. (2018). Cognitive Dysfunction in Major Depressive Disorder: Cause and Effect. Current Behavioral Neuroscience Reports, 5(4), 302-309.
2017 Hodyl, N., Aboustate, N., Bianco-Miotto, T., Roberts, C., Clifton, V., & Stark, M. (2017). Child neurodevelopmental outcomes following preterm and term birth: what can the placenta tell us?. Placenta, 57, 79-86.
DOI Scopus7 WoS3
Year Citation 2018 Froessler, B., Zorron, L., Aboustate, N., & Singh, R. (2018). An evaluation of dynamic clot formation in endoscopic mucosal resection. In 19th Annual Symposium on Patient Blood Management, Haemostasis and Thrombosis. Lisbon, Portugal. 2018 Aboustate, N., clifton, V. L., stark, M. J., & hodyl, N. A. (2018). Maternal cigarette smoking in pregnancy alters expression of microRNAs (miRs) that regulate inflammatory processes in cord blood. In Inflammation in Reproduction, Pregnancy and Development. cairns, australia. 2016 Aboustate, N., Clifton, V., Stark, M., & Hodyl, N. (2016). MICRORNAS REGULATING TOLL LIKE RECEPTOR INFLAMMATORY PATHWAYS IN PRETERM AND TERM PLACENTA AND CORD BLOOD. In PLACENTA Vol. 45 (pp. 87-88). Portland, OR: W B SAUNDERS CO LTD.
2015 Aboustate, N., Clifton, V. L., Stark, M. J., & Hodyl, N. A. (2015). Differential expression of microRNAs that regulate TLR pathways in cord blood and placentae from preterm deliveries. In Placenta Vol. 36. Brisbane: Elsevier.
Year Citation 2016 Aboustate, N., Stark, M. J., Clifton, V. C., & Hodyl, N. A. (2016). Maternal cigarette smoking in pregnancy alters expression of microRNAs (miRs) that regulate inflammation in the placenta and cord blood. Poster session presented at the meeting of Abstracts of the 3rd Annual DOHaD ANZ Annual Conference: Shaping our future. Adelaide, SA: The DOHaD Society of Australia and New Zealand. 2016 Aboustate, N., Clifton, V. C., Stark, M. J., & Hodyl, N. A. (2016). MicroRNAs regulating Toll Like Receptor inflammatory pathways in preterm and term placenta and cord blood. Poster session presented at the meeting of Abstracts of the International Federation of Placental Associations, as published in Placenta. Portland, Oregon, USA: Elsevier.
2014 Aboustate, N., Clifton, V. L., Stark, M. J., & Hodyl, N. A. (2014). Cord Blood microRNAs that regulate TLR Pathways are differentially expressed depending on gestational age.. Poster session presented at the meeting of ESA-SRB: Proceedings 2014. Melbourne. 2014 Aboustate, N., Clifton, V. L., Pitcher, J. B., Stark, M. J., & Hodyl, N. A. (2014). Expression of MicroRNAs that regulate inflammation in cord blood from Preterm Neonates.. Poster session presented at the meeting of FNWS Proceedings 2014. Yanchep, WA. 2014 Aboustate, N., Clifton, V. L., Pitcher, J. B., Stark, M. J., & Hodyl, N. A. (2014). Prenatal Betamethasone therapy increases stimulated cord blood pro-inflammatory cytokine responses in preterm neonates.. Poster session presented at the meeting of NAHLN Research Day. Mawson Lakes, SA. 2013 Hodyl., Aboustate., Clifton., & Stark. (2013). Cord blood from preterm infants demonstrates an exaggerated pro-inflammatory response following pathogen exposure. Poster session presented at the meeting of Developmental Origins of Health and Disease Congress. Singapore. 2013 Hodyl., Aboustate., Clifton., & Stark. (2013). Cord blood from preterm infants demonstrates an exaggerated pro-inflammatory response following pathogen exposure. Poster session presented at the meeting of Developmental Origins of Health and Disease Congress. Singapore.
Flinders University- Quantitative Research Methods (2017)
Date Role Committee Institution Country 2018 - ongoing Member Biological Psychiatry Australia Biological Psychiatry Australia Australia 2016 - ongoing Board Member Biological Society of South Australia — Australia
Date Institution Department Organisation Type Country 2014 - ongoing Placenta Journal — — —
Date Event Name Event Type Institution Country 2018 - 2018 Biological Psychiatry Australia Conference 2018 Conference Biological Psychiatry Austalia Australia
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