Dr Moustafa Mabrouk
Postdoctoral Researcher, TI&I Program
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr. Moustafa T. Mabrouk earned his PhD in Biomedical Engineering in 2024 from the University at Buffalo, New York. With a passion for integrating engineering principles with medical sciences, Dr. Mabrouk has dedicated his research to advancing healthcare technologies and improving patient outcomes.
During his doctoral studies, Dr. Mabrouk focused on developing innovative vaccine strategies for infectious diseases and cancer. His research developing a COVID-19 vaccine during the pandemic was published in Science Advances and highlighted by media has been recognized for its potential to develop a thermostable human vaccine.
In addition to his research, Dr. Mabrouk has actively contributed to the academic community. He has published over 20 peer-reviewed articles including five first authors and presented his findings at numerous international conferences such as ASTMH.
Dr. Mabrouk moved from USA to Australia to join SAiGENCI with the aspiration of developing a new cancer vaccine, leveraging his expertise in biomaterials and immunology. His interdisciplinary approach and collaborative spirit have allowed him to effectively engage with a diverse range of professionals, including engineers, scientists, and healthcare providers.
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Education
Date Institution name Country Title 2020 - 2024 University at Buffalo, State University of New York United States PhD 2018 - 2020 University at Buffalo, State University of New York United States MSc 2016 - 2018 Alexandria University Egypt MSc 2009 - 2014 Alexandria University Egypt PharmB
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Journals
Year Citation 2024 Jiao, Y., Huang, W. C., Chiem, K., Song, Y., Sun, J., Chothe, S. K., . . . Lovell, J. F. (2024). SARS-CoV-2 Protein Nanoparticle Vaccines Formed In Situ From Lyophilized Lipids. Small, 20(9), 12 pages.
2023 Mabrouk, M. T., Zidan, A. A., Aly, N., Mohammed, M. T., Ghantous, F., Seaman, M. S., . . . Nasr, M. L. (2023). Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens. Vaccines, 11(11), 14 pages.
Scopus2 Europe PMC12023 Zhou, S., Yu, K. O. A., Mabrouk, M. T., Jahagirdar, D., Huang, W. C., Guerra, J. A., . . . Lovell, J. F. (2023). Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens. Biomedical Journal, 46(6), 100588.
Scopus6 Europe PMC32022 McLeod, B., Mabrouk, M. T., Miura, K., Ravichandran, R., Kephart, S., Hailemariam, S., . . . Julien, J. P. (2022). Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses. Immunity, 55(9), 1680-1692.e8.
Scopus27 Europe PMC212022 Huang, W. C., Mabrouk, M. T., Zhou, L., Baba, M., Tachibana, M., Torii, M., . . . Lovell, J. F. (2022). Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages. Communications Biology, 5(1), 773.
Scopus15 Europe PMC122022 Sun, B., Ghosh, S., He, X., Huang, W. C., Quinn, B., Tian, M., . . . Lovell, J. F. (2022). Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel. Nano Research, 15(5), 4302-4309.
Scopus122022 Mabrouk, M. T., Huang, W. C., Martinez-Sobrido, L., & Lovell, J. F. (2022). Advanced Materials for SARS-CoV-2 Vaccines. Advanced Materials, 34(12), e2107781.
Scopus29 Europe PMC192021 Mabrouk, M. T., Chiem, K., Rujas, E., Huang, W. C., Jahagirdar, D., Quinn, B., . . . Lovell, J. (2021). Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice. Science Advances, 7(49), eabj1476.
Scopus30 Europe PMC172021 Mabrouk, M. T., Zhang, H., Zidan, A. A., Kilian, H. I., Huang, W. C., Jahagirdar, D., . . . Lovell, J. F. (2021). Cross-linked Histone as a Nanocarrier for Gut Delivery of Hydrophobic Cargos. ACS Applied Materials and Interfaces, 13(23), 26712-26720.
Scopus7 Europe PMC12021 He, X., Zhou, S., Huang, W. C., Seffouh, A., Mabrouk, M. T., Morgan, M. T., . . . Lovell, J. F. (2021). A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8<sup>+</sup>T Cell Epitopes. ACS Nano, 15(3), 4357-4371.
Scopus47 Europe PMC242020 Huang, W. C., Zhou, S., He, X., Chiem, K., Mabrouk, M. T., Nissly, R. H., . . . Lovell, J. F. (2020). SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination. Advanced Materials, 32(50), 11 pages.
Scopus75 Europe PMC552020 Sun, B., Jing, H., Mabrouk, M. T., Zhang, Y., Jin, H., & Lovell, J. F. (2020). A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology, 25(10), 1281-1288.
Scopus10 Europe PMC32020 Mabrouk, M. T., Huang, W. C., Deng, B., Li-Purcell, N., Seffouh, A., Ortega, J., . . . Lovell, J. F. (2020). Lyophilized, antigen-bound liposomes with reduced MPLA and enhanced thermostability. International Journal of Pharmaceutics, 589, 8 pages.
Scopus18 Europe PMC132020 Huang, W. C., Deng, B., Mabrouk, M. T., Seffouh, A., Ortega, J., Long, C., . . . Lovell, J. F. (2020). Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose. Malaria Journal, 19(1), 12 pages.
Scopus19 Europe PMC172019 Miranda, D., Wan, C., Kilian, H. I., Mabrouk, M. T., Zhou, Y., Jin, H., & Lovell, J. F. (2019). Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation. Biomaterials Science, 7(8), 3158-3164.
Scopus37 Europe PMC162018 Gaber, M., Mabrouk, M. T., Freag, M. S., Khiste, S. K., Fang, J. Y., Elkhodairy, K. A., & Elzoghby, A. O. (2018). Protein-polysaccharide nanohybrids: Hybridization techniques and drug delivery applications. European Journal of Pharmaceutics and Biopharmaceutics, 133, 42-62.
Scopus43 Europe PMC92018 Abd Elwakil, M. M., Mabrouk, M. T., Helmy, M. W., Abdelfattah, E. Z. A., Khiste, S. K., Elkhodairy, K. A., & Elzoghby, A. O. (2018). Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma. Nanomedicine, 13(16), 2015-2035.
Scopus72 Europe PMC112018 Abdelaziz, H. M., Gaber, M., Abd-Elwakil, M. M., Mabrouk, M. T., Elgohary, M. M., Kamel, N. M., . . . Elzoghby, A. O. (2018). Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. Journal of Controlled Release, 269, 374-392.
Scopus289 Europe PMC1022017 Sabra, S., Abdelmoneem, M., Abdelwakil, M., Mabrouk, M. T., Anwar, D., Mohamed, R., . . . Elzoghby, A. (2017). Self-assembled nanocarriers based on amphiphilic natural polymers for anti-cancer drug delivery applications. Current Pharmaceutical Design, 23(35), 5213-5229.
Scopus63 Europe PMC182016 Elzoghby, A. O., Abd-Elwakil, M. M., Abd-Elsalam, K., Elsayed, M. T., Hashem, Y., & Mohamed, O. (2016). Natural polymeric nanoparticles for brain-targeting: Implications on drug and gene delivery. Current Pharmaceutical Design, 22(22), 3305-3323.
Scopus95 Europe PMC29
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2024 Co-Supervisor Reprogramming Tumor-Associated Macrophages with mRNA Encapsulated Plant-Based Virus-like Nanoparticles for Immunotherapy of Triple Negative Breast Cancer Master of Philosophy (Medical Science) Master Full Time Miss Uta Ishikawa
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