Mr Moustafa Mabrouk
Grant-Funded Researcher (A)
SAIGENCI
College of Health
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr. Moustafa T. Mabrouk earned his PhD in Biomedical Engineering in 2024 from the University at Buffalo, New York. With a passion for integrating engineering principles with medical sciences, Dr. Mabrouk has dedicated his research to advancing healthcare technologies and improving patient outcomes.During his doctoral studies, Dr. Mabrouk focused on developing innovative vaccine strategies for infectious diseases and cancer. His research developing a COVID-19 vaccine during the pandemic was published in Science Advances and highlighted by media has been recognized for its potential to develop a thermostable human vaccine.In addition to his research, Dr. Mabrouk has actively contributed to the academic community. He has published over 20 peer-reviewed articles including five first authors and presented his findings at numerous international conferences such as ASTMH.Dr. Mabrouk moved from USA to Australia to join SAiGENCI with the aspiration of developing a new cancer vaccine, leveraging his expertise in biomaterials and immunology. His interdisciplinary approach and collaborative spirit have allowed him to effectively engage with a diverse range of professionals, including engineers, scientists, and healthcare providers.
| Date | Institution name | Country | Title |
|---|---|---|---|
| 2020 - 2024 | University at Buffalo, State University of New York | United States | PhD |
| 2018 - 2020 | University at Buffalo, State University of New York | United States | MSc |
| 2016 - 2018 | Alexandria University | Egypt | MSc |
| 2009 - 2014 | Alexandria University | Egypt | PharmB |
| Year | Citation |
|---|---|
| 2025 | Shi, Y., Hou, Y., Mabrouk, M. T., Yu, C., & Yang, Y. (2025). In Situ Vaccines in the Era of Cancer Immunotherapy: Conceptual Innovation and Clinical Translation. Advanced Science, 12(37), 23 pages. Scopus1 WoS2 Europe PMC1 |
| 2024 | Jiao, Y., Huang, W. C., Chiem, K., Song, Y., Sun, J., Chothe, S. K., . . . Lovell, J. F. (2024). SARS-CoV-2 Protein Nanoparticle Vaccines Formed In Situ From Lyophilized Lipids. Small, 20(9), e2304534. Scopus3 WoS10 Europe PMC3 |
| 2023 | Zhou, S., Yu, K. O. A., Mabrouk, M. T., Jahagirdar, D., Huang, W. C., Guerra, J. A., . . . Lovell, J. F. (2023). Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens. Biomedical Journal, 46(6), 100588. Scopus9 Europe PMC7 |
| 2023 | Mabrouk, M. T., Zidan, A. A., Aly, N., Mohammed, M. T., Ghantous, F., Seaman, M. S., . . . Nasr, M. L. (2023). Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens. Vaccines, 11(11), 1655. Scopus4 WoS3 Europe PMC5 |
| 2022 | McLeod, B., Mabrouk, M. T., Miura, K., Ravichandran, R., Kephart, S., Hailemariam, S., . . . Julien, J. P. (2022). Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses. Immunity, 55(9), 1680-1692.e8. Scopus38 Europe PMC42 |
| 2022 | Huang, W. C., Mabrouk, M. T., Zhou, L., Baba, M., Tachibana, M., Torii, M., . . . Lovell, J. F. (2022). Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages. Communications Biology, 5(1), 773. Scopus23 Europe PMC23 |
| 2022 | Sun, B., Ghosh, S., He, X., Huang, W. C., Quinn, B., Tian, M., . . . Lovell, J. F. (2022). Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel. Nano Research, 15(5), 4302-4309. Scopus13 |
| 2022 | Mabrouk, M. T., Huang, W. C., Martinez-Sobrido, L., & Lovell, J. F. (2022). Advanced Materials for SARS-CoV-2 Vaccines. Advanced Materials, 34(12), e2107781. Scopus36 Europe PMC30 |
| 2021 | Mabrouk, M. T., Chiem, K., Rujas, E., Huang, W. C., Jahagirdar, D., Quinn, B., . . . Lovell, J. (2021). Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice. Science Advances, 7(49), eabj1476. Scopus38 Europe PMC29 |
| 2021 | Mabrouk, M. T., Zhang, H., Zidan, A. A., Kilian, H. I., Huang, W. C., Jahagirdar, D., . . . Lovell, J. F. (2021). Cross-linked Histone as a Nanocarrier for Gut Delivery of Hydrophobic Cargos. ACS Applied Materials and Interfaces, 13(23), 26712-26720. Scopus7 WoS5 Europe PMC2 |
| 2021 | He, X., Zhou, S., Huang, W. C., Seffouh, A., Mabrouk, M. T., Morgan, M. T., . . . Lovell, J. F. (2021). A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8<sup>+</sup>T Cell Epitopes. ACS Nano, 15(3), 4357-4371. Scopus58 WoS54 Europe PMC48 |
| 2020 | Huang, W. C., Zhou, S., He, X., Chiem, K., Mabrouk, M. T., Nissly, R. H., . . . Lovell, J. F. (2020). SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination. Advanced Materials, 32(50), e2005637. Scopus86 WoS80 Europe PMC74 |
| 2020 | Sun, B., Jing, H., Mabrouk, M. T., Zhang, Y., Jin, H., & Lovell, J. F. (2020). A surfactant-stripped cabazitaxel micelle formulation optimized with accelerated storage stability. Pharmaceutical Development and Technology, 25(10), 1281-1288. Scopus12 WoS10 Europe PMC5 |
| 2020 | Mabrouk, M. T., Huang, W. C., Deng, B., Li-Purcell, N., Seffouh, A., Ortega, J., . . . Lovell, J. F. (2020). Lyophilized, antigen-bound liposomes with reduced MPLA and enhanced thermostability. International Journal of Pharmaceutics, 589, 119843. Scopus20 WoS20 Europe PMC17 |
| 2020 | Huang, W. C., Deng, B., Mabrouk, M. T., Seffouh, A., Ortega, J., Long, C., . . . Lovell, J. F. (2020). Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose. Malaria Journal, 19(1), 309. Scopus21 WoS22 Europe PMC20 |
| 2019 | Miranda, D., Wan, C., Kilian, H. I., Mabrouk, M. T., Zhou, Y., Jin, H., & Lovell, J. F. (2019). Indocyanine green binds to DOTAP liposomes for enhanced optical properties and tumor photoablation. Biomaterials Science, 7(8), 3158-3164. Scopus42 WoS35 Europe PMC30 |
| 2018 | Gaber, M., Mabrouk, M. T., Freag, M. S., Khiste, S. K., Fang, J. Y., Elkhodairy, K. A., & Elzoghby, A. O. (2018). Protein-polysaccharide nanohybrids: Hybridization techniques and drug delivery applications. European Journal of Pharmaceutics and Biopharmaceutics, 133, 42-62. Scopus52 WoS44 Europe PMC29 |
| 2018 | Abd Elwakil, M. M., Mabrouk, M. T., Helmy, M. W., Abdelfattah, E. Z. A., Khiste, S. K., Elkhodairy, K. A., & Elzoghby, A. O. (2018). Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma. Nanomedicine, 13(16), 2015-2035. Scopus81 WoS64 Europe PMC45 |
| 2018 | Abdelaziz, H. M., Gaber, M., Abd-Elwakil, M. M., Mabrouk, M. T., Elgohary, M. M., Kamel, N. M., . . . Elzoghby, A. O. (2018). Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates. Journal of Controlled Release, 269, 374-392. Scopus346 WoS305 Europe PMC207 |
| 2017 | Sabra, S., Abdelmoneem, M., Abdelwakil, M., Mabrouk, M. T., Anwar, D., Mohamed, R., . . . Elzoghby, A. (2017). Self-assembled nanocarriers based on amphiphilic natural polymers for anti-cancer drug delivery applications. Current Pharmaceutical Design, 23(35), 5213-5229. Scopus72 WoS56 Europe PMC37 |
| 2016 | Elzoghby, A. O., Abd-Elwakil, M. M., Abd-Elsalam, K., Elsayed, M. T., Hashem, Y., & Mohamed, O. (2016). Natural polymeric nanoparticles for brain-targeting: Implications on drug and gene delivery. Current Pharmaceutical Design, 22(22), 3305-3323. Scopus109 WoS92 Europe PMC61 |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2024 | Co-Supervisor | Reprogramming Tumor-Associated Macrophages with mRNA Encapsulated Plant-Based Virus-like Nanoparticles for Immunotherapy of Triple Negative Breast Cancer | Master of Philosophy (Medical Science) | Master | Full Time | Miss Uta Ishikawa |
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