School of Biological Sciences
Faculty of Sciences
- My Research
- Grants and Funding
- Professional Activities
To reduce the social and financial impacts of Alzheimer's Disease, preventative treatments are needed. An increased understanding of Alzheimer's Disease is essential to the development of such treatments. Despite over 60,000 publications on Alzheimer's disease, there is still intense disagreement about what actually causes the disease. We do know that the majority of inherited cases of Alzheimer's disease are caused by changes in the Presenilin gene. We know that this gene is centrally important to the functioning of cells, but we are only beginning to understand how it works. Our laboratory is unique since we use an increasingly popular system, the zebrafish. Like humans, zebrafish possess a version of the Presenilin gene. We are currently the world's leading laboratory using zebrafish to investigate genes involved in Alzheimer's Disease. Our current aim is to generate zebrafish that have changes in their Presenilin gene that is similar to what is seen in Alzheimer's Disease. These fish will be a very valuable resource for further research on Presenilin function and will help us increase our understanding of the mechanisms behind Alzheimer's Disease.
Date Position Institution name 2008 - ongoing Post-Doctoral Researcher The University of Adelaide 2007 - ongoing Co-Manager of the Adelaide Zebrafish Facility The University of Adelaide
Awards and Achievements
Date Type Title Institution Name Country Amount 2012 Research Award The Research Career Development Network, Research Achievement Award — — — 2009 Award School of Molecular and Bionedical Science Postgraduate Student Academic Acheivement Award — — —
Date Institution name Country Title 2005 - 2008 The University of Adelaide Australia PhD Biosciences 2004 - 2004 The University of Adelaide Australia Honours Degree of Bachelor of Health Sciences 2000 - 2003 The University of Adelaide Australia Bachelor of Science
Year Citation 2015 Lardelli, M., Ebrahimie, E., Newman, M., Nik, S. M., & Hoek, M. V. D. (2015). Transcriptome analyses using human and zebrafish brain data reveal hypoxia as an important element in Alzheimer's disease. In JOURNAL OF NEUROCHEMISTRY Vol. 134 (pp. 324). Cairns, AUSTRALIA: WILEY-BLACKWELL.
Year Citation — Newman, M. (n.d.). Gene editing in zebrafish to produce the psen1 K97fs mutation.
- NHMRC - Project Grant CIB: $755,792, 2017-2019. Identifying early molecular changes underlying familial Alzheimer’s disease.
- NHMRC - Project Grant CID: $1,314,000, 2016-2019. Genetic Pathways to Cerebral Palsy
- NHMRC - Project Grant CIB: $602,000, 2014-2016. Defining the changes in cell biology caused by PRESENILIN truncations assoictaed with different diseases.
- Alzheimer’s Australia Research - Dementia Research Grant: $47,000, 2012. Modeling of FAD-like and PS2V-like PRESENILIN mutations in zebrafish embryos.
- The Australian Federation of University Women - South Australian Postdoctoral Grant: $5000, 2012. Investigating the normal and aberrant functions of the Presenilin genes.
- Alzheimer’s Australia Research - Dementia Research Grant: $25,000, 2010. Definition of the critical region for truncation of Presenilin 1 which results in upregualtion of g-secretase activity.
- Guest lecturer for Fundamentals of Biological Psychiatry, 2015-2016.
- Mentor/Supervisor for the courses:
- Biology I, Human Perspectives, Small Group Discovery, 2014-2016.
- BSc Advanced program, Research Review, 2016.
- MBBS Program, Year 3 Research and Clinical Reasoning course, Research Proposal Project, 2016.
- Tutor for the courses:
- Genetics IIA and IIB, 2006-2008 and 2011-2012
- Scientific Basis of Medicine II, 2013 and 2015.
- Practical Demonstrator for the courses:
- Gene Expression and Human Developmental Genetics III, 2007-2008 and 2011-2012
- Molecular and Biomedical Science Practicals, 2006-2008.
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2017 - 2021 Co-Supervisor Investigating Alzheimer’s disease using zebrafish genetic models Doctor of Philosophy Doctorate Full Time Mr Yang Dong 2017 - 2021 Co-Supervisor Investigating the effects of mutations causative for early-onset familial Alzheimer’s disease using zebrafish as a model organism Doctor of Philosophy Doctorate Full Time Miss Karissa Barthelson 2015 - 2020 Co-Supervisor Investigations of y-secretase substrates Amyloid precursor protein and p75 neurotrophin receptor in zebrafish Doctor of Philosophy Doctorate Full Time Tanya Jayne 2014 - 2018 Co-Supervisor Identifying the pathological changes caused by familial Alzheimer’s disease-like mutations in zebrafish psen2 Doctor of Philosophy Doctorate Full Time Ms Haowei Jiang
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2016 - ongoing Co-Supervisor Genome engineering in the zebrafish The University of Adelaide — Honours — Hyo Jung Lim 2015 - ongoing Principal Supervisor Determining subcellular localisation via fluorescence microscopy The University of Adelaide — Honours — Matthew Hay 2015 - ongoing Co-Supervisor Generating a presenilin 1 zebrafish knockout The University of Adelaide — Honours — Kathleen Cuijvers 2014 - ongoing Principal Supervisor Genomic engineering in zebrafish The University of Adelaide — Honours — Nicholas James Gunn 2014 - ongoing Co-Supervisor In-vivo assay measuring autophagy in zebrafish The University of Adelaide — Honours — Nilakshi Dhananjani Dhanushika Ratnayake 2013 - ongoing Co-Supervisor In-vivo gamma-secretase assay using zebrafish embryos. The University of Adelaide — Honours — Oliver Puczkowski 2013 - ongoing Co-Supervisor In-vivo assays using zebrafish The University of Adelaide — Honours — Tanya Jayne 2010 - ongoing Co-Supervisor Alternatives to Morpholino Antisense Oligonucleotides The University of Adelaide — Honours — Anne Lim Hwee Ling
Date Topic Location Name 2015 - ongoing Investigation of cerebral palsy related genes using the zebrafish The University of Adelaide Mahlia Frank 2011 - ongoing Analysis of PS2V biological function in Alzheimer's Disease The University of Adelaide Seyed Hani Moussavi Nik 2008 - ongoing In-vivo gamma secretase assay using zebrafish The University of Adelaide Lachlan Wilson 2007 - ongoing Investigating presenilin 1 in the zebrafish The University of Adelaide Jason Greenslade
Date Role Membership Country 2015 - ongoing Member Genetics Society Australia — 2014 - ongoing Member Australian Neuroscience Society —
Date Role Editorial Board Name Institution Country 2016 - ongoing Associate Editor Frontiers in Aging Neuroscience — — 2009 - ongoing Associate Editor The Journal of Alzheimer’s Disease — —
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