Monika Kutyna

Monika Kutyna

Higher Degree by Research Candidate

School of Biomedicine

Faculty of Health and Medical Sciences


I am a third year student undertaking PhD under the supervision of Prof Stan Gronthos and Dr Devendra Hiwase. My project focuses on the role of bone marrow microenvironment in the pathogenesis of myeloid neoplasms where I developed complex in vtiro assays to study mesenchymal stromal cell (MSC) and drug targeting using primary cells. I also established a repository of biospecimens (MSC, bone marrow and blood mononuclear cells) from patients with myeloid neoplasms and age-matched controls. I am also instrumental in contributing to the south Australian Myelodysplastic Syndromes (SA-MDS) Registry by correlating experimental data with patient clinical information (i.e. treatment history, family history) and outcomes. Since commencing my PhD, I have co-authored 4 publications in peer reviewed journals (Leukemia, Haematologica) and presented at 16 national and international conferences (International Society of Experimental Hematology and American Society of Hematology).

Therapy-related myeloid neoplasms (t-MN) are poorly understood blood cancers associated with extremely poor clinical outcomes causing early death in otherwise long-term cancer survivors. It accounts for ~20% of cases of myeloid neoplasms and is expected to rise by 2035 due to the increased use of chemotherapy and improved survival of cancer patients (Leukemia Foundation).The current paradigm ignores the contribution of aberrant bone marrow microenvironment and myeloid neoplasms are considered primarily to be haematopoietic stem cells (HSC) autonomous disorders, in which initiation and progression are mainly driven by HSC intrinsic genetic events.

Therefore, my project focuses on the role of bone marrow microenvironment in the pathogenesis of myeloid neoplasms, speciffically t-MN,  where I developed complex in vtiro assays to study mesenchymal stromal cell (MSC) and drug targeting using primary cells. I also established a repository of biospecimens (MSC, bone marrow and blood mononuclear cells) from patients with myeloid neoplasms and age-matched controls. 

Faculty of Health Sciences Divisional Scholarship and Dawes Supplementary Scholarship


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