Monika Kutyna
Adelaide Medical School
Faculty of Health and Medical Sciences
I am an early career postdoctoral researcher with an emerging track record, on a trajectory to establish myself as an independent investigator in the field of bone marrow microenvironment research. My project focuses on the role of bone marrow microenvironment in the pathogenesis of myeloid neoplasms where I developed complex in vtiro assays to study mesenchymal stromal cell (MSC) and drug targeting using primary cells. I also established a repository of biospecimens (MSC, bone marrow and blood mononuclear cells) from patients with myeloid neoplasms and age-matched controls. I am also instrumental in contributing to the South Australian Myeloid Neoplasms (SA-MN) Registry by correlating experimental data with patient clinical information (i.e. treatment history, family history) and outcomes.
Therapy-related myeloid neoplasms (t-MN) are poorly understood blood cancers associated with extremely poor clinical outcomes causing early death in otherwise long-term cancer survivors. It accounts for ~20% of cases of myeloid neoplasms and is expected to rise by 2035 due to the increased use of chemotherapy and improved survival of cancer patients (Leukemia Foundation).The current paradigm ignores the contribution of aberrant bone marrow microenvironment and myeloid neoplasms are considered primarily to be haematopoietic stem cells (HSC) autonomous disorders, in which initiation and progression are mainly driven by HSC intrinsic genetic events.
Therefore, my project focuses on the role of bone marrow microenvironment in the pathogenesis of myeloid neoplasms, speciffically t-MN, where I developed complex in vtiro assays to study mesenchymal stromal cell (MSC) and drug targeting using primary cells. I also established a repository of biospecimens (MSC, bone marrow and blood mononuclear cells) from patients with myeloid neoplasms and age-matched controls.
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Appointments
Date Position Institution name 2024 - ongoing Affiliate Associate Lecturer University of Adelaide 2022 - ongoing Postdoctoral Researcher South Australian Health and Medical Research Institute 2022 - ongoing Postdoctoral Researcher Central Adelaide Local Health Network -
Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review Polish Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 2017 - 2022 University of Adelaide Australia PhD -
Research Interests
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Journals
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Conference Papers
Year Citation 2024 Kamel, M. M., Robinson, N., Kutyna, M., Lim, K., Thompson-Peach, C., Lane, S. W., . . . Thomas, D. (2024). High Dose Ascorbate Reduces Interleukin-1 Beta Secretion in TET2 Mutant Monocytes and Demonstrates Excellent and in CMML Patients in Combination with Azacitidine. In BLOOD Vol. 144 (pp. 1817-1818). ELSEVIER.
DOI WoS22024 Kutyna, M., Thomas, D., & Hiwase, D. (2024). Impact of Chronic Inflammation and Cytotoxic Therapy on Bone Marrow Microenvironment of Patients with Autoimmune Rheumatic Diseases and Myeloid Neoplasms. In BLOOD Vol. 144 (pp. 1304-1305). ELSEVIER.
DOI2024 Shah, M., Hung, K., Baranwal, A., Price, Z., Al-Kali, A., Toop, C., . . . Hiwase, D. (2024). The 66th ASH Annual Meeting Abstract Abstracts. In BLOOD Vol. 144 (pp. 3214). ELSEVIER. 2024 Lim, K., Kutyna, M., Kan, W., Lopez, A. F., Brown, A., Yong, A. S. M., . . . Thomas, D. (2024). CBL Variants in Chronic Myelomonocytic Leukemia Exhibit a Complex Sub-Clone Architecture with a High Frequency of RING Domain Mutations Sufficient to Induce GM-CSF Hypersensitivity. In BLOOD Vol. 144 (pp. 3196-3197). ELSEVIER.
DOI2024 Wechalekar, G., Cibich, A., Kutyna, M., Shanmuganathan, N., Sekaran, U. C., Singhal, D., . . . Hiwase, D. (2024). Clonal Architecture of Donor-Derived Leukemia/Clonal Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplant. In BLOOD Vol. 144 (pp. 4928-4929). FL, Orlando: ELSEVIER.
DOI2024 Hiwase, D., Price, Z., Kok, C. H., Kutyna, M., Singhal, D., Shanmuganathan, N., . . . Scott, H. S. (2024). Pathogenic Germline Variants in the DNA Damage Repair Pathway Are Enriched in Patients with Hematologic Malignancies with Prior Exposure to Cytotoxic Therapies Compared to Patients with Multiple Cancers without Prior Exposure. In BLOOD Vol. 144 (pp. 4596-4597). FL, Orlando: ELSEVIER.
DOI2022 Shah, M., Hahn, C. N., Chhetri, R., Tran, E. N. H., Singhal, D., Hogan, W. J., . . . Hiwase, D. (2022). Integrated Personalized Prediction Model Identifies a Subgroup of Wild-Type TP53therapy-Related Myeloid Neoplasm Patients with Poor Outcome. In BLOOD Vol. 140 (pp. 6964-6965). LA, New Orleans: ELSEVIER.
DOI2021 Chhetri, R., Sharplin, K., Proudman, W., Kutyna, M. M., Nayar, S., Singhal, D., . . . Hiwase, D. (2021). Hypomethylating Therapy Does Not Improve Outcome of Therapy-Related Myeloid Neoplasm Including TP53 Mutated and Complex Karyotype SubgroupsHypomethylating Therapy Does Not Improve Outcome of Therapy-Related Myeloid Neoplasm Including TP53 Mutated and Complex Karyotype Subgroups. In BLOOD Vol. 138 (pp. 3702-+). GA, Atlanta: ELSEVIER.
DOI WoS42021 Kutyna, M. M., Kok, C. H., Paton, S., Cakouros, D., Arthur, A., Hughes, T. P., . . . Hiwase, D. (2021). Distinct Senescent Bone Marrow Microenvironment in Therapy-Related Myeloid Neoplasms. In BLOOD Vol. 138 (pp. 4 pages). GA, Atlanta: AMER SOC HEMATOLOGY.
DOI WoS12021 Shah, M. V., Chhetri, R., Durani, U., Kutyna, M., Alkhateeb, H. B., Litzow, M. R., . . . Hiwase, D. (2021). T-MDS Is a Distinct Clinical and Pathological Entity Characterized By Better Survival Compared to t-AML. In BLOOD Vol. 138 (pp. 4 pages). GA, Atlanta: ELSEVIER.
DOI2021 Hahn, C. N., Feurstein, S. K., Singhal, D., Kutyna, M. M., Chhetri, R., Wee, A., . . . Hiwase, D. (2021). Unexpected High Frequency of Pathogenic Germline Variants in Older Adults with Primary Myelodysplastic Syndrome. In BLOOD Vol. 138 (pp. 4 pages). GA, Atlanta: ELSEVIER.
DOI WoS12021 Choong, J., Kutyna, M. M., Chhetri, R., Moore, S., & Hiwase, D. (2021). Frequency of Chromosomal Translocations Are Significantly Higher in Therapy Related Myeloid Neoplasm As Compared to Primary MDS. In BLOOD Vol. 138 (pp. 3 pages). GA, Atlanta: ELSEVIER.
DOI WoS12019 Singhal, D., Hahn, C. N., Moma, L. D., Wee, L. Y. A., Chhetri, R., Babic, M., . . . Hiwase, D. K. (2019). Deleterious Germline Variants, Especially in the DNA Repair Pathway, Are Common in Patients with Non-Related Multiple Cancers, One of Them Being Hematological Malignancy. In BLOOD Vol. 134 (pp. 3 pages). Orlando, FL: AMER SOC HEMATOLOGY.
DOI WoS12017 Singhal, D., Wee, A., Parker, W., Moore, S., Babic, M., Feng, J., . . . Hiwase, D. K. (2017). Presence of Rare Germline Variants in Fanconi Anaemia Pathway Genes Confers a Poor Prognosis Comparable to <i>TP53</i> Mutations in Therapy-Related Myeloid Neoplasms. In BLOOD Vol. 130 (pp. 3 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
WoS22017 Hahn, C. N., Wee, A., Babic, M., Feng, J., Wang, P., Kutyna, M. M., . . . Scott, H. S. (2017). Duplication on Chromosome 14q Identified in Familial Predisposition to Myeloid Malignancies and Myeloproliferative Neoplasms. In BLOOD Vol. 130 (pp. 2 pages). Atlanta, GA: AMER SOC HEMATOLOGY.
WoS32016 Singhal, D., Strupp, C., Chhetri, R., Kutyna, M., Wee, L., Nath, S., . . . Germing, U. (2016). RBC-transfusion dependency improves the prognostic value of the revised-IPSS in MDS patients: analysis of South Australian and Dusseldorf MDS registries. In Proceedings of the 58th Annual Meeting and Exposition of the American Society of Hematology, as published in Blood Vol. 128 (pp. 1998). San Diego, CA: American Society of Hematology. 2016 Singhal, D., Strupp, C., Chhetri, R., Kutyna, M. M., Wee, L. A., Nath, S. V., . . . Germing, U. (2016). RBC-Transfusion Dependency Improves the Prognostic Value of the Revised-IPSS in MDS Patients: Analysis of South Australian and Dusseldorf MDS Registries. In BLOOD Vol. 128 (pp. 6 pages). San Diego, CA: AMER SOC HEMATOLOGY. 2016 Singhal, D., Wee, L. A., Parker, W. T., Moore, S., Babic, M., Feng, J., . . . Hiwase, D. K. (2016). The Frequency of Genetic Mutations in T-MN Is High and Comparable to Primary MDS but the Spectrum Is Different. In BLOOD Vol. 128 (pp. 5 pages). San Diego, CA: AMER SOC HEMATOLOGY.
DOI2015 Hahn, C. N., Babic, M., Schreiber, A. W., Kutyna, M. M., Wee, L. A., Brown, A. L., . . . Hiwase, D. (2015). Rare and Common Germline Variants Contribute to Occurrence of Myelodysplastic Syndrome. In BLOOD Vol. 126 (pp. 4 pages). Orlando, FL: AMER SOC HEMATOLOGY.
DOI WoS32013 Hiwase, D. K., Kutyna, M. M., Chhetri, R., Howell, S., Harrison, P. B., Nath, S. V., . . . To, L. B. (2013). Transfusion Dependency Is Associated With Inferior Survival Even In Very Low and Low Risk IPSS-R Patients. In BLOOD Vol. 122 (pp. 2 pages). New Orleans, LA: AMER SOC HEMATOLOGY.
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Conference Items
Year Citation 2019 Kutyna, M. M., Wee, A., Paton, S., Cakouros, D., Arthur, A., Chhetri, R., . . . Hiwase, D. K. (2019). Aberrant Bone Marrow Microenvironment in Therapy Related Myeloid Neoplasm (t-MN). Poster session presented at the meeting of BLOOD. FL, Orlando: ELSEVIER.
DOI WoS22018 Singhal, D., Wee, A., Kutyna, M. M., Babic, M., Chhetri, R., Parker, W., . . . Hiwase, D. K. (2018). Therapy-Related Myeloid Neoplasms (T-MN) and Primary MDS (PMDS) Patients with Very Low (VL) or Low (L) IPSS-R Score Share Clinical and Biological Characteristics and Have Similar Outcome. Poster session presented at the meeting of BLOOD. CA, San Diego: AMER SOC HEMATOLOGY.
DOI2018 Chhetri, R., Wee, A., Sinha, R., Kutyna, M. M., Gupta, S., Nath, L., . . . Hiwase, D. K. (2018). Red Cell Alloimmunisation Is Associated with Increased Red Cell Transfusion Requirements in Myelodysplastic Syndrome. Poster session presented at the meeting of BLOOD. San Diego, CA: AMER SOC HEMATOLOGY.
DOI WoS12017 Singhal, D., Wee, L. A., Babic, M., Parker, W., Moore, S., Feng, J., . . . Hiwase, D. (2017). THERAPY RELATED MYELOID NEOPLASMS (T-MN) SHOW HIGH MUTATION FREQUENCY AND A SPECTRUM DIFFERENT FROM PRIMARY MDS. Poster session presented at the meeting of LEUKEMIA RESEARCH. Valencia, SPAIN: PERGAMON-ELSEVIER SCIENCE LTD.
DOI2014 Hiwase, D. K., Singhal, D., Chhetri, R., Kutyna, M. M., Harrison, P. B., Nath, S. V., . . . To, L. B. (2014). Inclusion of RBC-Transfusion Dependency Can Improve the Prognostic Value of Revised-IPSS in MDS Patients. Poster session presented at the meeting of BLOOD. San Francisco, CA: AMER SOC HEMATOLOGY. -
Preprint
Year Citation 2023 Hong, L. E., Wechalekar, M. D., Kutyna, M. M., Small, A., Lim, K., Thompson-Peach, C., . . . Hiwase, D. K. (2023). Seronegative Rheumatoid Arthritis and Innate Immune Activation is Frequent in Myeloid Neoplasms with Isocitrate Dehydrogenase 1/2 Mutations.
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Faculty of Health Sciences Divisional Scholarship and Dawes Supplementary Scholarship
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