Michelle Lane

Professor Michelle Lane


Adelaide Medical School

Faculty of Health and Medical Sciences

Dr Michelle Lane.
Our Mission:- Basic Science Influencing Clinical Outcomes
We all originate from the joining of two transcriptionally silent cells, the egg and sperm, that together initiate our genetic program and establish our developmental trajectory. We now understand that modifications to the molecular constituency of either the egg or the sperm not only impact the viability of the resultant embryo, but also programs our growth in utero which can influence our disease risk as adults. Obesity and other lifestyle factors have been shown to change these molecular marks in both eggs and sperm which impacts the health of the next generation. Obesity in reproductive aged men and women has increased exponentially in the last three decades such that now >50% of women and men are overweight or obese at conception. In fact with obesity as a key driver, it is reported that this generation will be the first to live shorter lives than their parents. Understanding the pathways of transmission of parental environmental insults to the next generation are essential for developing strategies to intervene in this cycle of generation to generation of poor health.

Our Goals:-
The research focus of the Gamete and Embryo Laboratory is to establish the functional pathways in this transmission of parental health cues to the next generation and to identify the characteristics of a “good” egg and sperm. Our research program principally focuses on how obesity and sub-fertility, impact the metabolic health and epigenetic marks in eggs, sperm and the preimplantation embryo to alter the growth and development of the offspring.

Our Achievements:-
In addition to our academic outcomes, Prof. Lane has more than 15 products sold worldwide in clinical IVF that have originated from our research outcomes. In 2015/2016 we have filed 2 new patents which we hope will result in better outcomes for couples undergoing IVF.
Prof. Lane has been involved in several start up companies for development of medical devices and in delivery of clinical IVF. As a founding Director of Adelaide Fertility Centre she oversees several IVF labs to provide the best embryology outcomes for couples around Australia.

  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 Co-Supervisor The Effect of GM-GSF on In Vitro Oocyte Maturation (IVM) Doctor of Philosophy Doctorate Full Time Mr Anmol Saini
    2015 Principal Supervisor Epigenetic Programming in the Early Embryo Doctor of Philosophy Doctorate Full Time Mr Alexander Penn
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2013 - 2019 Principal Supervisor The Effect of Dietary Micronutrient Supplementation on the Reproductive Health of Obese Males Doctor of Philosophy Doctorate Full Time Miss Helana Selange Shehadeh
    2011 - 2014 Principal Supervisor Mitochondrial Sirtuin 3 and Sirtuin 5 in granulosa and cumulus cells and their contribution to the altered follicular environment in women with either reduced ovarian reserve or advanced maternal age Doctor of Philosophy Doctorate Part Time Mrs Leanne Pacella-Ince
    2011 - 2014 Principal Supervisor The effect of diet and exercise interventions for the treatment of male obesity induced sub fertility Doctor of Philosophy Doctorate Full Time Dr Nicole Olivia Mc Pherson
    2010 - 2013 Principal Supervisor Culturing Embryos from the Cleavage to Blastocyst Stage; an Opportunity to Improve Pluripotency and Embryonic Stem Cell Generation Efficiency Doctor of Philosophy Doctorate Full Time Dr Jared Campbell
    2009 - 2012 Co-Supervisor The Role of the Hexosamine Biosynthesis Pathway and Beta-O-Linked Glycosylation in Determining Oocyte Developmental Competence Doctor of Philosophy Doctorate Full Time Ms Laura Frank
    2008 - 2010 Co-Supervisor Identification of Molecular Markers of Pregnancy Success for Assisted Reproduction Doctor of Philosophy Doctorate Full Time Miss Kathryn Gebhardt
    2008 - 2010 Principal Supervisor The Effect of Paternal Obesity on Sperm Function, Embryo Development and Subsequent Pregnancy Outcomes Doctor of Philosophy Doctorate Full Time Mr Hassan Bakos
    2007 - 2010 Principal Supervisor Importance of Oocyte to Cumulus Bi-Directional Signalling on Oocyte and Subsequent Embryo and Foetal Development and Viability Doctor of Philosophy Doctorate Part Time Miss Christine Yeo
    2006 - 2010 Principal Supervisor The Impact of In-Vitro Stress of Pre-Implantation Embryo Development, Viability and Mitochondrial Homeostasis Doctor of Philosophy Doctorate Full Time Miss Deirdre Zander
    2006 - 2010 Principal Supervisor Determination of Non-Invasive Viability Markers for Human Embryos in In Vitro Fertilization Doctor of Philosophy Doctorate Part Time Ms Deanne Kate Inglis
  • Board Memberships

    Date Role Board name Institution name Country
    2006 - ongoing Board Member Adelaide Fertility Centre Australia
  • Committee Memberships

    Date Role Committee Institution Country
    2014 - ongoing Advisory Board Member Monash IVF Education and Research Committee Monash IVF Group Australia
    2006 - 2015 Member Scientific Advisory Committee Repromed Australia
  • Position: Professor
  • Phone: 83138176
  • Email: michelle.lane@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 5
  • Room: WS5060.01
  • Org Unit: Paediatrics and Reproductive Health

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