Michael Samuel

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Professor Michael Samuel
Head, Tumour Microenvironment Laboratory
Qualifications: BSc(Hons.) ANU, PhD Melb
Centre for Cancer Biology
SA Pathology and University of South Australia
Bradley Building, North Terrace
Adelaide SA 5000, Australia.

Previously:
The Beatson Institute for Cancer Research, Glasgow, United Kingdom

My Research
Career
Publications
Supervision
Contact

Many key characteristics of the tissue microenvironment are fundamentally changed in cancer, yielding the tumour microenvironment. Some of these changes arise as a result of tumours co-opting and modifying features of the tissue microenvironment to facilitate their growth.

Our research seeks to identify the mechanisms by which tumours remodel their microenvironments to promote tumour progression, with a view to uncovering new approaches to interfering with this process.

The Rho-ROCK signalling pathway is known to regulate the contractility of the cellular actomyosin cytoskeleton to promote tumour cell migration and invasion. Less well-understood is its role in remodelling the tissue microenvironment. We have discovered that activation of the ROCK kinase causes over-production and abnormal remodelling of collagen and other ECM components in many tissues. The resulting increase in tissue density disrupts normal tissue homeostasis and promotes tumourigenesis. We research the mechanisms downstream of ROCK that regulate these processes in both health and disease, with a focus on cancer.

Current research projects

The molecular mechanisms by which the Rho-ROCK pathway promotes enhanced mechano-reciprocity and tumour progression
How does the Rho-ROCK pathway generate a tumour-permissive immune microenvironment?
How is the Rho-ROCK pathway regulated during wound healing and cancer progression?
Identifying novel negative regulators of mechano-reciprocity.

Learn more about our research.

Selected publications

S. T. Boyle, V. Poltavets, J. Kular, N. T. Pyne, J. J. Sandow, A. C. Lewis, K. J. Murphy, N. Kolesnikoff, P. A. B. Moretti, M. N. Tea, V. Tergaonkar, P. Timpson, S. M. Pitson, A. I. Webb, R. J. Whitfield, A. F. Lopez, M. Kochetkova and M. S. Samuel. "ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism". Nature Cell Biology 22(7):882-895 (2020).

S. T. Boyle, J. Kular, M. Nobis, A. Ruszkiewicz, P. Timpson and M. S. Samuel. "Acute compressive stress activates RHO/ROCK-mediated cellular processes". Small GTPases 11(5):354-370 (2020).

M. Z. Johan and M. S. Samuel. "Rho-ROCK signaling regulates tumour-microenvironment interactions". Biochem. Soc. Trans. 41(1):101-108 (2019).

H. A. Neubauer, M. N. Tea, J. R. Zebol, B. L. Gliddon, C. Stefanidis, P. A. B. Moretti, M. R. Pitman, M. Costabile, J. Kular, B. W. Stringer, B. W. Day, M. S. Samuel, C. S. Bonder, J. A. Powell and S. M. Pitson. Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma. Oncogene 38(8):1151-1165 (2019).

V. Poltavets, M. Kochetkova, S. M. Pitson and M. S. Samuel. "The role of the extra-cellular matrix and its molecular and cellular regulators in cancer cell plasticity". Frontiers in Oncology 8:431 (2018).

A. S. Cazet, M. N. Hui, B. L. Elsworth, S. Z. Wu, D. Roden, C. L. Chan, J. N. Skhinas, R. Collot, J. Yang, K. Harvey, M. Z. Johan, C. Cooper, R. Nair, D. Herrmann, A. McFarland, N. Deng, M. Ruiz-Borrego, F. Rojo, J. M. Trigo, S. Bezares, R. Caballero, E. Lim, P. Timpson, S. O'Toole, D. N. Watkins, T. R. Cox, M. S. Samuel, M. Martín and A. Swarbrick. Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer. Nat. Commun. 9(1):2897 (2018).

N. Rath, J. P. Morton, L. Julian, L. Helbig, S. Kadir, E. J. McGhee, K. I. Anderson, G. Kalna, M. Mullin, A. V. Pinho, I. Rooman, M. S. Samuel and M. F. Olson. "ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth". EMBO Mol Medicine 9(2):198-218 (2017).

C. Vennin, V. T. Chin, S. C.Warren, M. C. Lucas, D. Herrmann, A. Magenau, P. Melenec, S. N. Walters, G. Del Monte-Nieto, J. R. Conway, M. Nobis, A. H. Allam, R. A. McCloy, N. Currey, M. Pinese, A. Boulghourjian, A. Zaratzian, A. A. Adam, C. Heu, A. M. Nagrial, A. Chou, A. Steinmann, A. Drury, D. Froio, M. Giry-Laterriere, N. L. Harris, T. Phan, R. Jain, W. Weninger, E. J. McGhee, R. Whan, A. L. Johns, J. S. Samra, L. Chantrill, A. J. Gill, M. Kohonen-Corish, R. P. Harvey, A. V. Biankin; Australian Pancreatic Cancer Genome Initiative (APGI), T. R. Evans, K. I. Anderson, S. T. Grey, C. J. Ormandy, D. Gallego-Ortega, Y. Wang, M. S. Samuel, O. J. Sansom, A. Burgess, T. R. Cox, J. P. Morton, M. Pajic and Timpson P. Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Sci Transl Med. 9(384):eaai8504 (2017).

M. S. Samuel, N. Rath, S. F. Masre, S. T. Boyle, D. A. Greenhalgh, M. Kochetkova, S. Bryson, D. Stevenson and M. F. Olson. "Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein". Genesis 54(12):636-646 (2016).

S. T. Boyle and M. S. Samuel. "Mechano-reciprocity is maintained between physiological boundaries by tuning signal flux through the Rho-associated protein kinase". Small GTPases 7(3): 139-146 (2016).

J. Kular, K. G. Scheer, N. T. Pyne, A. H. Allam, A. Pollard, A. Magenau, R. Wright, N, Kolesnikoff, P. A. Moretti, L. Wullkopf, F. Stomski, A. J. Cowin, J. M. Woodcock, M. A. Grimbaldeston, S. M. Pitson, P. Timpson, H. S. Ramshaw, A. F. Lopez and M. S. Samuel. "A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis." Developmental Cell 35(6): 759-774 (2015).

K. H. Yip, N. Kolesnikoff, C. Yu, N. Hauschild, H. Taing, L. Biggs, D. Goltzman, P. A. Gregory, P. H. Anderson, M. S. Samuel, S. J. Galli, A. F. Lopez and M. A. Grimbaldeston. "Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation." J Allergy Clin Immunol 133: 1356-1364.e14. (2014).

S. J. Ibbetson, N. T. Pyne, A. N. Pollard, M. F. Olson, M. S. Samuel. "Mechanotransduction Pathways Promoting Tumor Progression Are Activated in Invasive Human Squamous Cell Carcinoma." Am J Pathol. 183: 931-938 (2013).

M. S. Samuel , J. I. Lopez, E. J. McGhee, D. R. Croft, D. Strachan, P. Timpson, J. Munro, E. Schroder, J. Zhou, V. G. Brunton, N. Barker, H. Clevers, O. J. Sansom, K. I. Anderson, V. M. Weaver and M. F. Olson. "Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth." Cancer Cell 19: 776-791. (2011).

Appointments

Date Position Institution name
2021 - ongoing Professor of Matrix Biology University of South Australia
Education

Date Institution name Country Title
Beatson Institute United Kingdom Postdoctoral Training
University of Melbourne Australia Ph.D.
Australian National University Australia B.Sc.(Hons.)

Date	Position	Institution name
2021 - ongoing	Professor of Matrix Biology	University of South Australia

Institution name	Country	Title
Beatson Institute	United Kingdom	Postdoctoral Training
University of Melbourne	Australia	Ph.D.
Australian National University	Australia	B.Sc.(Hons.)

Journals

Year	Citation
2024	Li, M., Bennett, M. K., Toubia, J., Pope, V. S., Tea, M., Tamang, S., . . . Pitson, S. M. (2024). An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma. British Journal of Haematology, 204(2), 566-570. DOI
2024	Samuel, M. S., Lopez, J. I., McGhee, E. J., Croft, D. R., Strachan, D., Timpson, P., . . . Olson, M. F. (2024). Erratum: Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth (Cancer Cell (2011) 19(6) (776–791), (S1535610811001668), (10.1016/j.ccr.2011.05.008)). Cancer Cell, 42(2), 317. DOI
2024	Johan, M. Z., Pyne, N. T., Kolesnikoff, N., Poltavets, V., Esmaeili, Z., Woodcock, J. M., . . . Samuel, M. S. (2024). Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis.. The Journal of investigative dermatology, S0022-202X(24)00276-8. DOI
2023	Myo Min, K. K., Ffrench, C. B., McClure, B. J., Ortiz, M., Dorward, E. L., Samuel, M. S., . . . Bonder, C. S. (2023). Desmoglein-2 as a cancer modulator: friend or foe?. Frontiers in Oncology, 13, 15 pages. DOI
2023	Li, X., McLain, C., Samuel, M. S., Olson, M. F., & Radice, G. L. (2023). Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling. Development, 150(2), 1-14. DOI
2023	Samuel, M., Van, L., & Trevorrow, P. (2023). An interview with Michael Samuel ‐ Tumour Microenvironment Laboratory, Centre for Cancer Biology, SA Pathology and University of South Australia. Cytoskeleton, 80(3-4), 58-59. DOI WoS1
2023	Scheer, K. G., Ebert, L. M., Samuel, M. S., Bonder, C. S., & Gomez, G. A. (2023). Bevacizumab-Induced Hypertension in Glioblastoma Patients and Its Potential as a Modulator of Treatment Response. Hypertension, 80(8), 1590-1597. DOI Scopus1
2023	Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation.. Life Sci Alliance, 6(10), 1-17. DOI
2022	Law, A. M. K., Chen, J., Colino-Sanguino, Y., Fuente, L. R. D. L., Fang, G., Grimes, S. M., . . . Gallego-Ortega, D. (2022). ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo. Advanced Science, 9(21), 2103332-1-2103332-19. DOI Scopus1 Europe PMC3
2022	Le Cerf, B. A., Pyne, N. T., Kular, J., Boyle, S. T., Beattie, D. A., Krasowska, M., & Samuel, M. S. (2022). Nano-Mechanical Analyses of Native and Cross-Linked Collagen I Matrices Reveal the Mechanical Complexity of Homogenous Samples. Frontiers in Physics, 10, 11 pages. DOI
2022	Kochetkova, M., & Samuel, M. S. (2022). Differentiation of the tumor microenvironment: are CAFs the Organizer?. Trends in Cell Biology, 32(4), 285-294. DOI Scopus24 WoS26 Europe PMC18
2022	Kolesnikoff, N., Chen, C. -H., & Samuel, M. S. (2022). Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression. Clinical Science, 136(5), 361-377. DOI Scopus13 WoS7 Europe PMC8
2021	Zadeh Shirazi, A., McDonnell, M. D., Fornaciari, E., Bagherian, N. S., Scheer, K. G., Samuel, M. S., . . . Gomez, G. A. (2021). A deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma. British Journal of Cancer, 125(3), 337-350. DOI Scopus17 WoS13 Europe PMC11
2021	Floerchinger, A., Murphy, K. J., Latham, S. L., Warren, S. C., McCulloch, A. T., Lee, Y. -K., . . . Nobis, M. (2021). Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: guidance using optical window intravital FRET imaging. Cell Reports, 36(11), 109689-1-109689-e6. DOI Scopus11 WoS8 Europe PMC8
2021	Murphy, K. J., Reed, D. A., Vennin, C., Conway, J. R. W., Nobis, M., Yin, J. X., . . . Timpson, P. (2021). Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Science Advances, 7(40), eabh0363-1-eabh0363-27. DOI Scopus22 WoS19 Europe PMC17
2021	Poltavets, V., Esmaeili, Z., Boyle, S. T., Ramshaw, H. S., Lopez, A. F., Kochetkova, M., & Samuel, M. S. (2021). 14-3-3ζ-depletion impairs mammary gland development in the mouse. DOI
2020	Boyle, S. T., Johan, M. Z., & Samuel, M. S. (2020). Tumour-directed microenvironment remodelling at a glance. Journal of Cell Science, 133(24), jcs247783-1-jcs247783-9. DOI Scopus10 WoS7 Europe PMC4
2020	Strudwick, X. L., Adams, D. H., Pyne, N. T., Samuel, M. S., Murray, R. Z., & Cowin, A. J. (2020). Systemic delivery of anti-integrin α L antibodies reduces early macrophage recruitment, inflammation, and scar formation in murine burn wounds. Advances in Wound Care, 9(12), 637-648. DOI Scopus17 WoS12 Europe PMC7
2020	Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895. DOI Scopus45 WoS40 Europe PMC28
2020	Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., . . . Samuel, M. S. (2020). Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.. Nat Cell Biol, 22(7), 908. DOI Scopus4 WoS4 Europe PMC3
2020	Boyle, S. T., Mittal, P., Kaur, G., Hoffmann, P., Samuel, M. S., & Klingler-Hoffmann, M. (2020). Uncovering tumor−stroma inter-relationships using MALDI Mass spectrometry imaging. Journal of Proteome Research, 19(10), 4093-4103. DOI Scopus13 WoS10 Europe PMC8
2019	Neubauer, H. A., Tea, M. N., Zebol, J. R., Gliddon, B. L., Stefanidis, C., Moretti, P. A. B., . . . Pitson, S. M. (2019). Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma. Oncogene, 38(8), 1151-1165. DOI Scopus19 WoS15 Europe PMC11
2019	Johan, M. Z., & Samuel, M. S. (2019). Rho–ROCK signaling regulates tumor-microenvironment interactions. Biochemical Society Transactions, 47(1), 101-108. DOI Scopus37 WoS31 Europe PMC20
2019	Perrin, S. L., Samuel, M. S., Koszyca, B., Brown, M. P., Ebert, L. M., Oksdath, M., & Gomez, G. A. (2019). Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments. Biochemical Society Transactions, 47(2), 625-638. DOI Scopus96 WoS85 Europe PMC70
2018	Poltavets, V., Kochetkova, M., Pitson, S. M., & Samuel, M. S. (2018). The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity. Frontiers in Oncology, 8(OCT), 431-1-431-19. DOI Scopus246 WoS217 Europe PMC163
2018	Cazet, A., Hui, M., Elsworth, B., Wu, S., Roden, D., Chan, C., . . . Swarbrick, A. (2018). Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer. Nature Communications, 9(1), 2897N-1-2897N-18. DOI Scopus278 WoS245 Europe PMC195
2018	Hercus, T., Kan, W., Broughton, S., Tvorogov, D., Ramshaw, H., Sandow, J., . . . Lopez, A. (2018). Role of the β common (βc) family of cytokines in health and disease. Cold Spring Harbor Perspectives in Biology, 10(6), a028514. DOI Scopus31 WoS21 Europe PMC15
2018	Boyle, S. T., Kular, J., Nobis, M., Ruszkiewicz, A., Timpson, P., & Samuel, M. S. (2018). Acute compressive stress activates RHO/ROCK-mediated cellular processes. Small GTPases, 11(5), 1-17. DOI Scopus33 Europe PMC20
2017	Nobis, M., Herrmann, D., Warren, S., Kadir, S., Leung, W., Killen, M., . . . Timpson, P. (2017). A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts. Cell Reports, 21(1), 274-288. DOI Scopus72 WoS64 Europe PMC57
2017	Vennin, C., Chin, V., Warren, S., Lucas, M., Herrmann, D., Magenau, A., . . . Timpson, P. (2017). Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis. Science Translational Medicine, 9(384), eaai8504-1-eaai8504-17. DOI Scopus193 WoS174 Europe PMC127
2017	Akladios, B., Mendoza-Reinoso, V., Samuel, M. S., Hardeman, E. C., Khosrotehrani, K., Key, B., & Beverdam, A. (2017). Epidermal YAP2-5SA-ΔC drives β-catenin activation to promote keratinocyte proliferation in mouse skin in vivo. Journal of Investigative Dermatology, 137(3), 716-726. DOI Scopus17 WoS14 Europe PMC13
2017	Rath, N., Morton, J. P., Julian, L., Helbig, L., Kadir, S., McGhee, E. J., . . . Olson, M. F. (2017). ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Molecular Medicine, 9(2), 198-218. DOI Scopus95 WoS89 Europe PMC70
2016	Grimbaldeston, M. A., Dixit, V. M., & Samuel, M. S. (2016). The 7th Barossa Meeting--Cell Signalling in Cancer Biology and Therapy in Barossa Valley, Australia. Cell death & disease, 7(3), e2129. DOI
2016	Boyle, S. T., & Samuel, M. S. (2016). Mechano-reciprocity is maintained between physiological boundaries by tuning signal flux through the Rho-associated protein kinase. Small GTPases, 7(3), 139-146. DOI Scopus24 Europe PMC13
2016	Neubauer, H. A., Pham, D. H., Zebol, J. R., Moretti, P. A. B., Peterson, A. L., Leclercq, T. M., . . . Pitson, S. M. (2016). An oncogenic role for sphingosine kinase 2. Oncotarget, 7(40), 64886-64899. DOI Scopus50 WoS47 Europe PMC38
2016	Samuel, M., Rath, N., Masre, S., Boyle, S., Greenhalgh, D., Kochetkova, M., . . . Olson, M. (2016). Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein. Genesis, 54(12), 636-646. DOI Scopus9 WoS8 Europe PMC6
2015	Kopecki, Z., Yang, G., Jackson, J., Melville, E., Caley, M., Murrell, D., . . . Cowin, A. (2015). Cytoskeletal protein flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression. Oncotarget, 6(34), 36426-36440. DOI Scopus22 WoS21 Europe PMC18
2015	Kular, J., Scheer, K., Pyne, N., Allam, A., Pollard, A., Magenau, A., . . . Samuel, M. (2015). A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis. Developmental Cell, 35(6), 759-774. DOI Scopus28 WoS22 Europe PMC19
2015	Woodcock, J., Coolen, C., Goodwin, K., Baek, D., Bittman, R., Samuel, M., . . . Lopez, A. (2015). Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics. Oncotarget, 6(16), 14522-14536. DOI Scopus29 WoS25 Europe PMC18
2014	Sadras, T., Perugini, M., Kok, C., Iarossi, D., Heatley, S., Brumatti, G., . . . D'Andrea, R. (2014). Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia. Journal of Leukocyte Biology, 96(1), 83-91. DOI Scopus14 WoS15 Europe PMC8
2014	Yip, K., Kolesnikoff, N., Yu, C., Hauschild, N., Taing, H., Biggs, L., . . . Grimbaldeston, M. (2014). Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation. Journal of Allergy and Clinical Immunology, 133(5), 1356-1379. DOI Scopus95 WoS84 Europe PMC61
2013	Ibbetson, S., Pyne, N., Pollard, A., Olson, M., & Samuel, M. (2013). Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma. American Journal of Pathology, 183(3), 930-937. DOI Scopus36 WoS31 Europe PMC29
2013	Lees, J., Ching, Y., Adams, D., Bach, C., Samuel, M., Kee, A., . . . O'Neill, G. (2013). Tropomyosin regulates cell migration during skin wound healing. Journal of Investigative Dermatology, 133(5), 1330-1339. DOI Scopus33 WoS32 Europe PMC17
2012	Jamieson, T., Clarke, M., Steele, C., Samuel, M., Neumann, J., Jung, A., . . . Sansom, O. (2012). Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), 3127-3144. DOI Scopus300 WoS270 Europe PMC233
2011	Samuel, M. S., & Olson, M. F. (2011). Actomyosin contractililty: force power drives tumor growth. Cell Cycle, 10(20), 3409-3410. DOI Scopus8 WoS6 Europe PMC7
2011	Samuel, M., Lopez, J., McGhee, E., Croft, D., Strachan, D., Timpson, P., . . . Olson, M. (2011). Actomyosin-mediated cellular tension drives increased tissue stiffness and B-catenin activation to induce interfollicular epidermal hyperplasia and tumor growth. Cancer Cell, 19(6), 776-791. DOI Scopus430 WoS402 Europe PMC338
2011	Croft, D., Crighton, D., Samuel, M., Lourenco, F., Munro, J., Wood, J., . . . Olson, M. (2011). p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), 666-682. DOI Scopus63 WoS60 Europe PMC49
2011	Samuel, M., Lourenco, F., & Olson, M. (2011). K-Ras Mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity. PLoS One, 6(2), e17143-1-e17143-7. DOI Scopus29 WoS27 Europe PMC26
2010	Buchert, M., Athineos, D., Abud, H., Burke, Z., Faux, M., Samuel, M., . . . Ernst, M. (2010). Genetic dissection of differential signaling threshold requirements for the Wnt/β-Catenin pathway in vivo. PLoS Genetics, 6(1), e1000816 (13 pages). DOI Scopus78 WoS66 Europe PMC60
2010	Samuel, M., & Olson, M. (2010). Dying alone: A tale of Rho. Cell Stem Cell, 7(2), 135-136. DOI Scopus8 WoS7 Europe PMC5
2009	Samuel, M., Munro, J., Bryson, S., Forrow, S., Stevenson, D., & Olson, M. (2009). Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus. Genesis, 47(7), 440-446. DOI Scopus19 WoS18 Europe PMC17
2009	Samuel, M., Suzuki, H., Buchert, M., Putoczki, T., Tebbutt, N., Lundgren-May, T., . . . Ernst, M. (2009). Elevated Dnmt3a Activity Promotes Polyposis in Apc(Min) Mice by Relaxing Extracellular Restraints on Wnt Signaling. Gastroenterology, 137(3), 902-913. DOI Scopus32 WoS29 Europe PMC27
2007	Samuel, M. S., Lundgren-May, T., & Ernst, M. (2007). Identification of putative targets of DNA (cytosine-5) methylationmediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3a. Growth Factors, 25(6), 426-436. DOI Scopus5 WoS4 Europe PMC4
2007	Boireau, S., Samuel, M. S., Pannequin, J., Ryan, J. L., Choquet, A., Chapuis, H., . . . Hollande, F. (2007). DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis, 28(2), 246-258. DOI Scopus70 WoS67 Europe PMC49
2006	Stuhlmann-Laeisz, C., Lang, S., Chalaris, A., Paliga, K., Sudarman, E., Eichler, J., . . . Scheller, J. (2006). Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Molecular Biology of the Cell, 17(7), 2986-2995. DOI Scopus60 WoS57 Europe PMC45
2005	Dauvillée, D., Kinderf, I. S., Li, Z., Kosar-Hashemi, B., Samuel, M. S., Rampling, L., . . . Morell, M. K. (2005). Role of the Escherichia coli glgX gene in glycogen metabolism. Journal of Bacteriology, 187(4), 1465-1473. DOI Scopus103 WoS89 Europe PMC66
2003	Morell, M. K., Kosar-Hashemi, B., Cmiel, M., Samuel, M. S., Chandler, P., Rahman, S., . . . Li, Z. Y. (2003). Barley <i>sex6</i> mutants lack starch synthase IIa activity and contain a starch with novel properties. PLANT JOURNAL, 34(2), 172-184. DOI WoS231
2003	Morell, M. K., Kosar-Hashemi, B., Cmiel, M., Samuel, M. S., Chandler, P., Rahman, S., . . . Li, Z. (2003). Barley sex6 mutants lack starch synthase lla activity and contain a starch with novel properties. Plant Journal, 34(2), 173-185. DOI Scopus271 Europe PMC127
1999	Dauvillée, D., Colleoni, C., Shaw, E., Mouille, G., D'Hulst, C., Morell, M., . . . Ball, S. (1999). Novel, starch-like polysaccharides are synthesized by an unbound form of granule-bound starch synthase in glycogen-accumulating mutants of Chlamydomonas reinhardtii. Plant Physiology, 119(1), 321-329. DOI Scopus32 WoS26 Europe PMC21
1999	Colleoni, C., Dauvillée, D., Mouille, G., Morell, M., Samuel, M., Slomiany, M. C., . . . Ball, S. (1999). Biochemical characterization of the Chlamydomonas reinhardtii α-1,4 glucanotransferase supports a direct function in amylopectin biosynthesis. Plant Physiology, 120(4), 1005-1014. DOI Scopus67 WoS57 Europe PMC39
1999	Colleoni, C., Dauvillée, D., Mouille, G., Buléon, A., Gallant, D., Bouchet, B., . . . Ball, S. (1999). Genetic and biochemical evidence for the involvement of α-1,4 glucanotransferases in amylopectin synthesis. Plant Physiology, 120(4), 993-1003. DOI Scopus79 WoS69 Europe PMC46
1998	Morell, M. K., Samuel, M. S., & O'Shea, M. G. (1998). Analysis of starch structure using fluorophore-assisted carbohydrate electrophoresis. Electrophoresis, 19(15), 2603-2611. DOI Scopus128 WoS120 Europe PMC55
1998	Rahman, S., Abrahams, S., Abbott, D., Mukai, Y., Samuel, M., Morell, M., & Appels, R. (1998). Erratum: A complex arrangement of genes at a starch branching enzyme I locus in the D-genome donor of wheat (Genome (1997) 40 (465-474)). Genome, 41(1), 139. DOI
1998	O'Shea, M. G., Samuel, M. S., Konik, C. M., & Morell, M. K. (1998). Fluorophore-assisted carbohydrate electrophoresis (FACE) of oligosaccharides: Efficiency of labelling and high-resolution separation. Carbohydrate Research, 307(1-2), 1-12. DOI Scopus235 WoS227
1998	Rahman, S., Abrahams, S., Abbott, D., Mukai, Y., Samuel, M., Morell, M., & Appels, R. (1998). A complex arrangement of genes at a starch branching enzyme I locus in the D-genome donor of wheat (vol 40, pg 465, 1997). GENOME, 41(1), 139. WoS1
1998	Rahman, S., Abrahams, S., Abbott, D., Mukai, Y., Samuel, M., Morell, M., & Appels, R. (1998). Erratum: A complex arrangement of genes at a starch branching enzyme I locus in the D-genome donor of wheat. Genome, 41(1), 139. DOI
1997	Morell, M. K., Blennow, A., Kosar-Hashemi, B., & Samuel, M. S. (1997). Differential expression and properties of starch branching enzyme isoforms in developing wheat endosperm. Plant Physiology, 113(1), 201-208. DOI Scopus134 WoS111 Europe PMC66
1997	Rahman, S., Abrahams, S., Abbott, D., Mukai, Y., Samuel, M., Morell, M., & Appels, R. (1997). A complex arrangement of genes at a starch branching enzyme I locus in the D-genome donor of wheat. Genome, 40(4), 465-474. DOI Scopus50 WoS50 Europe PMC30
1995	Rahman, S., Kosar-Hashemi, B., Samuel, M. S., Hill, A., Abbott, D. C., Skerritt, J. H., . . . Morell, M. K. (1995). The major proteins of wheat endosperm starch granules. Australian Journal of Plant Physiology, 22(5), 793-803. DOI Scopus132 WoS124

Book Chapters

Year	Citation
2021	Boyle, S., Poltavets, V., & Samuel, M. (2021). Mechanical Signaling in the Mammary Microenvironment: From Homeostasis to Cancer. In A. Birbrair (Ed.), Tumor Microenvironment : Novel Concepts (Vol. 1329, pp. 399-417). Springer. DOI
2018	Ramshaw, H., Kular, J., & Samuel, M. (2018). Wound Healing and the Non-cellular Microenvironment. In K. Turksen (Ed.), Wound Healing: Stem Cells Repair and Restorations, Basic and Clinical Aspects (pp. 79-87). New Jersey, USA: John Wiley & Sons. DOI Scopus1
2012	Samuel, M. S., & Olson, M. F. (2012). ROCK Kinases. In Encyclopedia of Signaling Molecules (pp. 1686-1690). Springer New York. DOI
2012	Samuel, M. S. (2012). RAS (H-, K-, N-RAS). In Encyclopedia of Signaling Molecules (pp. 1596-1601). Springer New York. DOI
2011	Samuel, M., & Olson, M. (2011). Rho-GTPases in Embryonic Stem Cells. In M. Kallos (Ed.), Embryonic Stem Cells - Basic Biology to Bioengineering (pp. 333-346). Online: InTech. DOI
2010	Wickman, G., Samuel, M., Lochhead, P., & Olson, M. (2010). The rho-regulated ROCK kinases in cancer. In K. van Golen (Ed.), The Rho GTPases in Cancer (pp. 163-192). USA: Springer. DOI Scopus7

Conference Papers

Year	Citation
2021	Shirazi, A. Z., McDonnell, M. D., Fornaciari, E., Bagherian, N. S., Scheer, K. G., Samuel, M. S., . . . Gomez, G. A. (2021). A deep convolutional neural network for segmentation of whole-slide pathology images in glioblastoma. In CLINICAL CANCER RESEARCH Vol. 27 (pp. 2 pages). AMER ASSOC CANCER RESEARCH. DOI
2019	Strudwick, X. L., Adams, D. H., Pyne, N. T., Samuel, M. S., Murray, R. Z., & Cowin, A. J. (2019). SYSTEMIC DELIVERY OF ANTI-INTEGRIN αL ANTIBODIES REDUCE EARLY MACROPHAGE RECRUITMENT, INFLAMMATION AND SCAR FORMATION IN MURINE BURN WOUNDS. In WOUND REPAIR AND REGENERATION Vol. 27 (pp. A4). WILEY.
2018	Strudwick, X. L., Adams, D. H., Pyne, N. T., Samuel, M. S., Murray, R. Z., & Cowin, A. J. (2018). SYSTEMIC DELIVERY OF ANTI-INTEGRIN AL ANTIBODIES REDUCES EARLY MACROPHAGE RECRUITMENT, INFLAMMATION, AND SCAR FORMATION IN MURINE BURN WOUNDS. In WOUND REPAIR AND REGENERATION Vol. 26 (pp. A31). WILEY.
2016	Rath, N., Kadir, S., Morton, J. P., Pinho, A. V., Helbig, L., Julian, L., . . . Olson, M. F. (2016). ROCK kinases drive invasive pancreatic tumor growth. In CANCER RESEARCH Vol. 76 (pp. 4 pages). San Diego, CA: AMER ASSOC CANCER RESEARCH. DOI
2012	Clarke, M., Jamieson, T., Steele, C., Olson, M., Samuel, M., Das, S., . . . Nibbs, R. (2012). Inhibition of neutrophil chemokine receptor CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. In IMMUNOLOGY Vol. 137 (pp. 190). Glasgow, SCOTLAND: WILEY-BLACKWELL. WoS2

Conference Items

Year	Citation
2014	Masre, S. F., Samuel, M. S., Olson, M. F., & Greenhalgh, D. A. (2014). Inducible <i>ROCK</i> <i>2</i>/<i>ras<SUP>Ha</SUP></i> cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible <i>ROCK</i> <i>2</i>/<i>PTEN</i> loss fails to achieve benign papilloma. Poster session presented at the meeting of CANCER RESEARCH. San Diego, CA: AMER ASSOC CANCER RESEARCH. DOI

Year

Citation

2014

Masre, S. F., Samuel, M. S., Olson, M. F., & Greenhalgh, D. A. (2014). Inducible ROCK 2/rasHa cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible ROCK 2/PTEN loss fails to achieve benign papilloma. Poster session presented at the meeting of CANCER RESEARCH. San Diego, CA: AMER ASSOC CANCER RESEARCH.
DOI

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2021	Principal Supervisor	Understanding how the Epigenetic Field Effect Exerted by Cancers upon their Microenvironment Promotes Tumour Progression	Doctor of Philosophy	Doctorate	Full Time	Miss Moganalaxmi Reckdharajkumar

Email: michael.samuel@adelaide.edu.au

Michael Samuel

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Conference Items

Current Higher Degree by Research Supervision (University of Adelaide)

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