Clinical Senior Lecturer
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Michael G. Collins MBChB FRACP PhD is a consultant nephrologist (kidney specialist) and clinical trialist working at the Royal Adelaide Hospital. He trained in Nephrology at Auckland City Hospital, New Zealand, and the Queen Elizabeth and Royal Adelaide Hospitals in Adelaide. From 2009-2013, he completed a PhD in transplant immunology with Professor Toby Coates at the University of Adelaide, while completing a number of clinical research projects including a multi-centre study of colorectal cancer screening in kidney transplant recipients. From this time onwards, he developed a strong interest in conducting high-quality clinical research with the goal of improving outcomes for kidney transplant recipients.
From 2013-2021, Dr Collins worked as a consultant nephrologist at Auckland City Hospital, in New Zealand. From 2014 to 2018, he led a cross-disciplinary research group that completed a single-centre randomised controlled trial of nutrition interventions in kidney transplant recipients.
In 2016, he proposed and ultimately became the co-lead investigator for the BEST-Fluids trial, a multi-centre, pragmatic, registry-based, investigator-initiated randomised controlled trial of IV fluid therapy in kidney transplant recipients. The trial was conducted as a collaboration between the Australasian Kidney Trials Network, the ANZDATA Registry and kidney transplant hospitals, clinicians and patients at 16 hospitals in Australia and New Zealand. The primary results of this study were published in the Lancet in 2023, and are expected to influence kidney transplant clinical practice worldwide, with further studies ongoing.
Dr Collins relocated to work at the Royal Adelaide Hospital in 2022 where he is a senior nephrologist in the Central Northern Adelaide Renal and Transplantation Service (CNARTS), and a titleholder (clinical senior lecturer) at the University of Adelaide. He is the Deputy Chair of the Australasian Kidney Trials Network, and an active researcher in clinical trials. His ongoing research focuses on designing and conducting the future clinical trials of peri-operative interventions in kidney transplantation that will improve outcomes for patients.
The BEST-Fluids trial
1. Link to Australasian Kidney Trials Network website - https://aktn.org.au/best-fluids/
2. Lancet infographic of the key results
3. The key trial results summarised in a short video
Date Position Institution name 2022 - ongoing Senior Consultant Nephrologist Royal Adelaide Hospital 2022 - ongoing Clinical Senior Lecturer University of Adelaide 2017 - ongoing Honorary Senior Fellow University of Queensland
Awards and Achievements
Date Type Title Institution Name Country Amount 2023 Research Award Kidney Health Australia Award for Best Clinical Research Presentation Transplantation Society of Australia and New Zealand Australia - 2021 Distinction Pass with Distinction Harvard Medical School United States - 2020 Fellowship Gavin and Ann Kellaway Medical Research Fellowship Auckland Medical Research Foundation New Zealand NZD 37,000 2017 Fellowship Jacquot Research Establishment Fellowship Royal Australasian College of Physicians Australia AUD 180,000 2011 Research Award Presidents Prize - Clinical Transplantation Society of Australia and New Zealand Australia - 2010 Research Award Young Investigator Award - Clinical Science Australian and New Zealand Society of Nephrology Australia -
Date Institution name Country Title 2009 - 2013 University of Adelaide Australia PhD 1998 - 2000 University of Auckland New Zealand MBChB 1995 - 1997 University of Auckland New Zealand Bachelor of Human Biology (BHB)
Date Title Institution Country 2021 - 2022 Global Clinical Scholars Research Training Program 2021-2022 Harvard Medical School United States 2001 - 2008 FRACP Royal Australasian College of Physicians New Zealand
Year Citation 2023 Logan, B., Viecelli, A., Johnson, D., Aquino, E., Bailey, J., Comans, T., . . . Yip, B. (2023). Study protocol for The GOAL Trial: comprehensive geriatric assessment for frail older people with chronic kidney disease to increase attainment of patient-identified goals—a cluster randomised controlled trial. Trials, 24(1), 1-15.
DOI Europe PMC1
2023 Collins, M. G., Fahim, M. A., Pascoe, E. M., Hawley, C. M., Johnson, D. W., Varghese, J., . . . Scherring, C. (2023). Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial. The Lancet, 402(10396), 105-117.
2022 Pascoe, E. M., Chadban, S. J., Fahim, M. A., Hawley, C. M., Johnson, D. W., & Collins, M. G. (2022). Statistical analysis plan for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a randomised controlled trial of the effect of intravenous fluid therapy with balanced crystalloid versus saline on the incidence of delayed graft function in deceased donor kidney transplantation. Trials, 23(1), 52-1-52-4.
DOI Scopus2 Europe PMC1
2022 Lim, W. H., Ooi, E., Pilmore, H. L., Johnson, D. W., McDonald, S. P., Clayton, P., . . . Wong, G. (2022). Interactions between donor age and 12-month estimated glomerular filtration rate on allograft and patient outcomes after kidney transplantation. Transplant International, 36, 10199-1-10199-10.
2022 Pascoe, E. M., Chadban, S. J., Fahim, M. A., Hawley, C. M., Johnson, D. W., & Collins, M. G. (2022). Correction to: Statistical analysis plan for better evidence for selecting transplant fluids (BEST-fluids): a randomised controlled trial of the effect of intravenous fluid therapy with balanced crystalloid versus saline on the incidence of delayed graft function in deceased donor kidney transplantation (Trials, (2022), 23, 1, (52), 10.1186/s13063-021-05989-w). Trials, 23(1), 1 page.
2022 Collins, M. G., Fahim, M. A., Pascoe, E. M., Hawley, C. M., Johnson, D. W., Varghese, J., . . . Chadban, S. J. (2022). Baseline Characteristics and Representativeness of Participants in the BEST-Fluids Trial: A Randomized Trial of Balanced Crystalloid Solution Versus Saline in Deceased Donor Kidney Transplantation. Transplantation Direct, 8(12), e1399.
DOI Scopus2 Europe PMC1
2022 Viecelli, A. K., Teixeira-Pinto, A., Valks, A., Baer, R., Cherian, R., Cippà, P. E., . . . Jenkins, S. (2022). Study protocol for Vascular Access outcome measure for function: a vaLidation study In hemoDialysis (VALID): A multi-center, multinational validation study to assess the accuracy and feasibility of measuring vascular access function in clinical practice. BMC Nephrology, 23(1), 372-1-372-12.
2021 Pei, J., Cho, Y., See, Y. P., Pascoe, E. M., Viecelli, A. K., Francis, R. S., . . . Johnson, D. W. (2021). Impact of deceased donor with acute kidney injury on subsequent kidney transplant outcomes-an ANZDATA registry analysis. PLoS ONE, 16(3 March), 19 pages.
DOI Scopus7 WoS7 Europe PMC5
2021 Weinberg, L., Collins, M. G., & Peyton, P. (2021). Urine the Right Direction: The Consensus Statement from the Committee on Transplant Anesthesia of the American Society of Anesthesiologists on Fluid Management during Kidney Transplantation. Transplantation, 105(8), 1655-1657.
2021 Lim, W. H., Adams, B., Alexander, S., Bouts, A. H. M., Claas, F., Collins, M., . . . Wong, G. (2021). Improve in-depth immunological risk assessment to optimize genetic-compatibility and clinical outcomes in child and adolescent recipients of parental donor kidney transplants: protocol for the INCEPTION study. BMC Nephrology, 22(1), 1-11.
2020 Wright, R. S., Collins, M. G., Stoekenbroek, R. M., Robson, R., Wijngaard, P. L. J., Landmesser, U., . . . Kallend, D. (2020). Effects of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Inclisiran: An Analysis of the ORION-7 and ORION-1 Studies. Mayo Clinic Proceedings, 95(1), 77-89.
DOI Scopus76 WoS65 Europe PMC32
2020 Collins, M. G., Fahim, M. A., Pascoe, E. M., Dansie, K. B., Hawley, C. M., Clayton, P. A., . . . BEST-Fluids Investigators and the Australasian Kidney Trials Network. (2020). Study Protocol for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a pragmatic, registry-based, multi-center, double-blind, randomized controlled trial evaluating the effect of intravenous fluid therapy with Plasma-Lyte 148 versus 0.9% saline on delayed graft function in deceased donor kidney transplantation. Trials, 21(1), 428-1-428-19.
DOI Scopus14 WoS13 Europe PMC6
2020 Htay, H., Pascoe, E. M., Hawley, C. M., Campbell, S. B., Chapman, J., Cho, Y., . . . Johnson, D. W. (2020). Patient and center characteristics associated with kidney transplant outcomes: a binational registry analysis. Transplant International, 33(12), 1667-1680.
DOI Scopus4 WoS3 Europe PMC2
2019 Collins, M. G., Symonds, E. L., Bampton, P. A., & Coates, P. T. (2019). Fecal immunochemical screening for advanced colorectal neoplasia in patients with CKD: Accurate or not?. Journal of the American Society of Nephrology, 30(11), 2275.
DOI Scopus1 Europe PMC1
2019 See, E. J., Hawley, C. M., Cho, Y., Toussaint, N. D., Agar, J. W. M., Pascoe, E. M., . . . Johnson, D. W. (2019). Comparison of graft and patient outcomes following kidney transplantation in extended hour and conventional haemodialysis patients. Nephrology, 24(1), 111-120.
DOI Scopus1 WoS1 Europe PMC1
2018 Henggeler, C. K., Plank, L. D., Ryan, K. J., Gilchrist, E. L., Casas, J. M., Lloyd, L. E., . . . Collins, M. G. (2018). A Randomized Controlled Trial of an Intensive Nutrition Intervention Versus Standard Nutrition Care to Avoid Excess Weight Gain After Kidney Transplantation: The INTENT Trial. Journal of Renal Nutrition, 28(5), 340-351.
DOI Scopus30 WoS27 Europe PMC13
2018 Kosloski, M. P., Zhao, W., Marbury, T. C., Preston, R. A., Collins, M. G., Pugatch, D., . . . Liu, W. (2018). Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects. Antimicrobial Agents and Chemotherapy, 62(3), 10 pages.
DOI Scopus20 WoS18 Europe PMC9
2017 Weinberg, L., Harris, L., Bellomo, R., Ierino, F. L., Story, D., Eastwood, G., . . . Mount, P. F. (2017). Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148 ® on hyperkalaemia in deceased donor renal transplantation: A double-blind randomized trial. British Journal of Anaesthesia, 119(4), 606-615.
DOI Scopus44 WoS37 Europe PMC22
2015 Collins, M. G., & Clayton, P. A. (2015). Thai transplant registry: An important resource for the Asia Pacific region. Nephrology, 20(4), 227-228.
2014 Collins, M. G., Rogers, N. M., Jesudason, S., Kireta, S., Brealey, J., & Coates, P. T. (2014). Spontaneous glomerular mesangial lesions in common marmoset monkeys (Callithrix jacchus): a benign non-progressive glomerulopathy. Journal of Medical Primatology, 43(6), 477-487.
DOI Scopus14 WoS14 Europe PMC10
2014 Ryan, K. J., Segedin Casas, J. M., Mash, L. E., McLellan, S. L., Lloyd, L. E., Stinear, J. W., . . . Collins, M. G. (2014). The effect of intensive nutrition interventions on weight gain after kidney transplantation: Protocol of a randomised controlled trial. BMC Nephrology, 15(1), 9 pages.
DOI Scopus20 WoS21 Europe PMC13
2012 Collins, M., Teo, E., Cole, S., Chan, C., McDonald, S., Russ, G., . . . Coates, P. (2012). Screening for colorectal cancer and advanced colorectal neoplasia in kidney transplant recipients: cross sectional prevalence and diagnostic accuracy study of faecal immunochemical testing for haemoglobin and colonoscopy. BMJ (Online), 345(7871), 1-14.
DOI Scopus40 WoS33 Europe PMC21
2012 Jesudason, S., Collins, M., Rogers, N., Kireta, S., & Coates, P. (2012). Non-human primate dendritic cells. Journal of Leukocyte Biology, 91(2), 217-228.
DOI Scopus12 WoS10 Europe PMC9
2009 Collins, M., Chang, S., Russ, G., & McDonald, S. (2009). Outcomes of Transplantation Using Kidneys From Donors Meeting Expanded Criteria in Australia and New Zealand, 1991 to 2005. Transplantation, 87(8), 1201-1209.
DOI Scopus30 WoS28 Europe PMC22
2009 Collins, M. G., Brunskill, A. J., McDonald, S. P., Collins, J. F., & Dittmer, I. D. (2009). KIDNEY TRANSPLANT OUTCOMES AMONG THE MAORI AND PACIFIC PEOPLES OF NEW ZEALAND. NEPHROLOGY, 14, A56. 1999 Collins, M. G. (1999). Medical students and debt: A survey of students at the School of Medicine, University of Auckland. New Zealand Medical Journal, 112(1085), 123-126.
Year Citation 2011 Collins, M. G., Bampton, P. A., Young, G. P., Cole, S. R., McDonald, S. P., Russ, G. R., & Coates, P. T. (2011). Colorectal Cancer and Pre-Malignant Colorectal Neoplasia Are Detected with Increased Prevalence in Prospectively Screened Asymptomatic Kidney Transplant Recipients and May Be Linked to Viral Infection. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 11 (pp. 510). Philadelphia, PA: WILEY-BLACKWELL. 2010 Collins, M. G., Teo, E., Chan, C., Young, G. P., Cole, S. R., McDonald, S. P., . . . Coates, P. T. (2010). Screening for Colorectal Cancer in Kidney Transplant Recipients: A Prospective Cross-Sectional Study of Faecal Immunochemical Testing Versus Colonoscopy. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 10 (pp. 472). San Diego, CA: WILEY-BLACKWELL PUBLISHING, INC.
Year Citation 2013 Collins, M. (2013). Developing a non-human primate model of dendritic cell based immunotherapy in transplantation: Studies in the common marmoset monkey (Callithrix jacchus). (PhD Thesis, University of Adelaide).
- New Zealand Health Research Council (HRC) Project Grant 2019: 19/268. Serum phosphate to improve outcomes for dialysis patients: The PHOSPHATE trial. NZD$1,266,603 [Named Investigator]
- Australian Government Medical Research Future Fund 2018: Rare Cancers, Rare Diseases and Unmet Needs Clinical Trials Program Grant: APP1152390. The BEST Fluids study. AUD$1,117,150 [Chief Investigator B]
- HRC Project Grant 2017: 17/414. The BEST Fluids study. NZD$549,035 [First Named Investigator/CIA]
- Royal Australasian College of Physicians. Jacquot Research Establishment Fellowship Grant 2017 and 2018. AUD $180,000.
- Better Evidence and Translation Chronic Kidney Disease (BEAT-CKD) grant 2016-7. Seed funding for The BEST Fluids study. AUD$200,000
- Auckland District Health Board Charitable Trust – Project grant 2015. Outcomes for Live Kidney Donors following Nephrectomy in Aotearoa New Zealand: the LIVE DONATE NZ study. NZD $30,000.00
- Auckland District Health Board Charitable Trust – Project grant 2013. Optimal nutrition intervention to prevent excessive weight gain post kidney transplantation: pilot randomised controlled trial. NZD $30,000.00
- ANZSN-Amgen Quality Assurance Grants 2014. Optimal nutrition intervention to prevent excessive weight gain post kidney transplantation: pilot randomised controlled trial. AUD $10,000.00
- CellCept Australia Research Grants, 2008. Screening for colorectal cancer in recipients of kidney transplants. AUD $20,000.00
- The Queen Elizabeth Hospital Research Foundation Research Grants, 2010. Screening for colorectal cancer in recipients of kidney transplants. AUD $10,000.00
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2022 Principal Supervisor Improving Post Operative Graft Function via a Personalised Goal Directed Therapy to manage Post-Operative Hypotension after Kidney Transplant. Master of Philosophy (Clinical Science) Master Full Time Mr Karthik Venkataraman
Other Supervision Activities
Date Role Research Topic Location Program Supervision Type Student Load Student Name 2021 - 2022 Co-Supervisor Obesity and Access to Kidney Transplantation University of Auckland Master of Nursing Master Part Time Peta Kelly 2020 - 2021 External Supervisor Thymoglobuline and the risk of delayed graft function after kidney transplantation University of Queensland Master of Pharmacy Master Part Time Emily McCulloch 2016 - 2017 Co-Supervisor Intensive Nutrition interventions to prevent weight after kidney transplantation University of Auckland Master of Health Science Master Full Time Cordula Henggeler 2015 - 2015 Co-Supervisor Intensive Nutrition interventions to prevent weight after kidney transplantation University of Auckland Master of Health Science Master Full Time Emily Gilchrist 2014 - 2014 Co-Supervisor Intensive Nutrition interventions to prevent weight after kidney transplantation University of Auckland Master of Health Science Master Full Time Kristin Ryan
Date Role Committee Institution Country 2020 - ongoing Vice-Chair Australasian Kidney Trials Network (AKTN) Scientific Committee University of Queensland Australia 2020 - 2021 Advisory Board Member National Renal Advisory Board Ministry of Health, New Zealand Government New Zealand 2017 - 2021 Member Australia and New Zealand Dialysis and Transplant Registry - Advisory Committee South Australian Health and Medical Research Institute Australia 2015 - 2021 Member Research Review Committee Auckland District Health Board New Zealand
Date Role Editorial Board Name Institution Country 2017 - 2021 Board Member Nephrology Asia Pacific Society of Nephrology Australia
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