Melanie Bertossa

Dr Melanie Bertossa

Research Assistant

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD as Co-Supervisor only - email supervisor to discuss availability.


I am a Postdoctoral Researcher in the Early Origins of Adult Health Research Group at the Robinson Research Institute. My research investigates the link between complicated pregnancies (e.g., poor maternal diet and fetal growth restriction) and increased risk of cardiovascular disease in offspring. My research utilises large preclinical animal models of human pregnancy (sheep and non-human primates) and a range of molecular techniques to investigate gene, protein, hormonal, and structural changes in the developing fetal heart. This helps me to understand how cardiovascular disease risk may originate in fetal life. I have developed a particular interest in the role of thyroid hormones and how altered thyroid–heart interactions contribute to high-risk CVD profiles in fetuses. My overall goal in characterising key mechanisms is to identify targets for both future diagnostic and therapeutic intervention. 

Language Competency
English -

Date Institution name Country Title
University of South Australia Australia Doctor of Physiology
University of South Australia Australia Bachelor of Medical Science

Year Citation
2026 Bertossa, M. R., Darby, J. R. T., Holman, S. L., Cho, S. K. S., Meakin, A. S., Lock, M. C., . . . Morrison, J. L. (2026). Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart. Journal of Physiology, 604(16), 6817-6839.
DOI Scopus5 WoS3 Europe PMC1
2026 Bertossa, M. R., Darby, J. R. T., Holman, S. L., Meakin, A. S., Lock, M. C., Li, C., . . . Morrison, J. L. (2026). Moderate nutrient restriction dysregulates molecular markers of calcium handling in the left ventricle of the non-human primate fetal heart. Journal of Physiology, 604(3), 1045-1066.
DOI Scopus1 WoS1
2026 Bertossa, M. R., Darby, J. R. T., Meakin, A. S., Lock, M. C., Cho, S. K. S., Macgowan, C. K., . . . Morrison, J. L. (2026). Insights from animal models: Dissecting the independent roles of oxygen and nutrients in the fetal origins of cardiovascular disease. Journal of Physiology, 604(16), 6704-6730.
DOI Scopus1 WoS1
2025 Amanollahi, R., Holman, S. L., Bertossa, M. R., Meakin, A. S., Clifton, V. L., Thornburg, K. L., . . . Morrison, J. L. (2025). Elevated cortisol concentration in preterm sheep fetuses impacts heart development. Experimental Physiology, 110(12), 1928-1947.
DOI Scopus5 WoS4 Europe PMC4
2025 Amanollahi, R., Holman, S. L., Bertossa, M. R., Meakin, A. S., Thornburg, K. L., McMillen, I. C., . . . Morrison, J. L. (2025). Ontogeny of Fetal Cardiometabolic Pathways: The Potential Role of Cortisol and Thyroid Hormones in Driving the Transition from Preterm to Near-Term Heart Development in Sheep. Journal of Cardiovascular Development and Disease, 12(2), 21 pages.
DOI Scopus14 WoS14 Europe PMC10
2025 Amanollahi, R., Bertossa, M., Thornburg, K., Wiese, M., Lock, M., & Morrison, J. (2025). Programming fetal cardiometabolic pathways: the double-edged role of glucocorticoids in heart development. Journal of Developmental Origins of Health and Disease, 16, 14 pages.
DOI Scopus1 WoS1
2024 Bertossa, M. R., Darby, J. R. T., Holman, S. L., Meakin, A. S., Li, C., Huber, H. F., . . . Morrison, J. L. (2024). Maternal high fat–high energy diet alters metabolic factors in the non-human primate fetal heart. Journal of Physiology, 602(17), 4251-4269.
DOI Scopus12 WoS11 Europe PMC8
2024 McGillick, E. V., Orgeig, S., Allison, B. J., Brain, K. L., Bertossa, M. R., Holman, S. L., . . . Giussani, D. A. (2024). Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood. Frontiers in Physiology, 15, 14 pages.
DOI Scopus3 WoS2 Europe PMC1

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