Mark Nottle

Research Interests

Fertility and Conception Pregnancy and Birth

APrf Mark Nottle

Associate Professor

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Associate Professor Mark NottleResearch Interests:The Reproductive Biotechnology Group has an international reputation in the general areas of reproductive biology and the development of associated technologies for biomedical and agricultural applications. In collaboration with a number of university, institute and hospital research groups in Australia as well as overseas, current research is focused in the general area of regenerative medicine in particular stem cell research, as well as the development of assisted reproductive technologies including in vitro oocyte maturation.

Isolation  and characterisation of a new  stem cell type

Current research in the Laboratory is  focussed on characterising a new embryonic  stem cell isolated by us .This breakthrough will  impact on the development of cell based therapies for a range of diseases including Type 1 diabetes  for which no effective treatment currently exists as well as having other applications such as drug discovery . This cell type is patent protected and we have formed  a Company to commercialise   this research.

Improving Human IVF outcomes

Other research being undertaken in the Laboratory  includes developing new approaches to human IVF aimed at overcoming the need for hormonal stimulation which is around half the cost of an IVF cycle. This involves adding hormones and growth factors found in the follicle to  in vitro oocyte maturation media and examining embryo development.

Biomarkers for  overcoming early embryonic loss

Industry sponsored research includes the development of molecular selection markers for improving livestock growth  and reproductive performance. The later of  which may has  implications for overcoming early embryonic loss and recurrent miscarriage in humans.

Honours and PhD projects are available in al of these areas.

Date Position Institution name
2016 - ongoing Director ICMStemcell Pty Ltd
2015 - 2019 Deputy Head, Adelaide Medical School University of Adelaide, Adelaide
2013 - 2015 Acting Head, School of Paediatrics and Reproductive Health University of Adelaide, Adelaide
2012 - 2016 Convenor, Higher Degrees by Research University of Adelaide, Adelaide
2007 - 2011 Director University of Adelaide, Adelaide
2005 - 2015 NHMRC Senior Research Fellow University of Adelaide, Adelaide
2003 - ongoing Associate Professor University of Adelaide, Adelaide

Date Type Title Institution Name Country Amount
2015 Fellowship Fellow, Society for Reproductive Biology. - - -

Date Institution name Country Title
1990 University of Adelaide, Adelaide Australia Doctor of Philosophy
1982 University of Adelaide, Adelaide Australia Bachelor of Agricultural Science Honours (First Class)
1981 University of Adelaide, Adelaide Australia Bachelor of Agricultural Science

Year Citation
2025 Whitty, A. L., Kind, K. L., Dunning, K. R., McPherson, N. O., & Nottle, M. B. (2025). GM-CSF treatment of frozen bovine sperm improves function, fertilization, and subsequent embryo development.. Theriogenology, 235, 46-55.
DOI Scopus3 WoS3 Europe PMC3
2025 Saini, A., McPherson, N. O., & Nottle, M. B. (2025). Determination of an Optimal Concentration of GM-CSF for Improving Oocyte in vitro Maturation in a Mouse Model. Fertility and Reproduction, 7(1), 1-4.
DOI
2025 Whitty, A. L., Jennings, S. K., Lyons, H. E., Thompson, J. G., Mcpherson, N. O., Kind, K. L., . . . Nottle, M. B. (2025). Addition of granulocyte-macrophage colony-stimulating factor during in vitro oocyte maturation improves cattle in vitro embryo production. Theriogenology, 247, 9 pages.
DOI
2024 McPherson, N. O., Nottle, M., McIlfatrick, S., Saini, A., Hamilton, H., Bowman, E., . . . Bakos, H. W. (2024). The clinical use of progesterone in human sperm preparation media for increasing IVF success. Reproductive Biomedicine Online, 48(4), 103625-1-103625-15.
DOI Scopus1 WoS1
2024 Salvaris, E. J., Fisicaro, N., McIlfatrick, S., Thomas, A., Fuller, E., Lew, A. M., . . . Cowan, P. J. (2024). Characterisation of transgenic pigs expressing a human T cell-depleting anti-CD2 monoclonal antibody. Xenotransplantation, 31(1), e12836-1-e12836-9.
DOI Scopus4 WoS4 Europe PMC7
2024 McLennan, H. J., Heinrich, S. L., Inge, M. P., Wallace, S. J., Blanch, A. J., Hails, L., . . . Love, A. K. (2024). A micro-fabricated device (microICSI) improves porcine blastocyst development and procedural efficiency for both porcine intracytoplasmic sperm injection and human microinjection. Journal of Assisted Reproduction and Genetics, 41(2), 297-309.
DOI Scopus6 WoS5
2024 Nottle, M. B., Vassiliev, I., Hawthorne, W. J., & Cowan, P. J. (2024). Porcine embryonic stem cells: An alternative solution for the shortage of human islets to treat type 1 diabetes?. Xenotransplantation, 31(1), 3 pages.
DOI Scopus1 WoS1
2024 Nottle, M. B., & Kleemann, D. O. (2024). Using lupins and the ram effect to improve reproductive performance in Merino ewes in southern Australia. Livestock Science, 280, 5 pages.
DOI
2024 Saini, A., McPherson, N. O., & Nottle, M. (2024). Addition of GM-CSF during in vitro oocyte maturation improves embryo development and implantation and birth rate in mice. Reproduction and Fertility, 5(3), e240020-1-e240020-8.
DOI Scopus4 WoS3 Europe PMC3
2024 Saini, A., McPherson, N. O., & Nottle, M. B. (2024). Addition of granulocyte macrophage colony stimulating factor (GM-CSF) during in vitro oocyte maturation improves embryo development in a mouse model of advanced maternal age.. The Journal of reproduction and development, 70(6), 411-417.
DOI Scopus1
2022 Hawthorne, W. J., Salvaris, E. J., Chew, Y. V., Burns, H., Hawkes, J., Barlow, H., . . . Cowan, P. J. (2022). Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons. Frontiers in Immunology, 13, 1-15.
DOI Scopus27 WoS23 Europe PMC22
2022 Nottle, M. B., Hawthorne, W. J., & Cowan, P. J. (2022). The birth of Dolly and xenotransplantation 25 years on. Xenotransplantation, 30(1), e12782.
DOI Scopus5 WoS4 Europe PMC4
2020 Fisicaro, N., Salvaris, E. J., Philip, G. K., Wakefield, M. J., Nottle, M. B., Hawthorne, W. J., & Cowan, P. J. (2020). FokI-dCas9 mediates high-fidelity genome editing in pigs. Xenotransplantation, 27(1), e12551-1-e12551-6.
DOI Scopus8 WoS7 Europe PMC6
2019 Cowan, P. J., Hawthorne, W. J., & Nottle, M. B. (2019). Xenogeneic transplantation and tolerance in the era of CRISPR-Cas9. Current Opinion in Organ Transplantation, 24(1), 5-11.
DOI Scopus33 WoS29 Europe PMC24
2017 Highet, A., Bianco-Miotto, T., Pringle, K., Peura, A., Bent, S., Zhang, J., . . . Roberts, C. (2017). A novel embryo culture media supplement that improves pregnancy rates in mice. Reproduction, 153(3), 327-340.
DOI Scopus12 WoS11 Europe PMC11
2017 Nottle, M., Salvaris, E., Fisicaro, N., McIlfatrick, S., Vassiliev, I., Hawthorne, W., . . . Cowan, P. (2017). Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9. Scientific Reports, 7(1), 8383-1-8383-8.
DOI Scopus35 WoS31 Europe PMC31
2016 Langendijk, P., Chen, T. Y., McIlfatrick, S. M., & Nottle, M. B. (2016). Energy balance influences number of ovulations rather than embryo quality in the pig. Theriogenology, 86(4), 1008-1013.
DOI Scopus3 WoS3 Europe PMC1
2015 Nottle, M. B., Hawthorne, W., O'Connell, P. J., d’Apice, A. J. F., & Cowan, P. J. (2015). Xenotransplantation transgenesis. Are we there yet?. Cloning & Transgenesis, 4(2), 1000137-1-1000137-2.
DOI
2015 Stewart, J., Tarantal, A., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., . . . Kearns-Jonker, M. (2015). Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models. Xenotransplantation, 22(6), 413-426.
DOI Scopus1 WoS1
2015 Le Bas-Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Châtelais, M., . . . Blancho, G. (2015). Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons. American Journal of Transplantation, 15(2), 358-370.
DOI Scopus30 WoS25 Europe PMC22
2015 Harrison, S., Beebe, L., Vassiliev, I., McIlfatrick, S., & Nottle, M. (2015). Multipotent cell types in primary fibroblast cell lines used to clone pigs using somatic cell nuclear transfer. Cloning & Transgenesis, 4(2), 1000136-1-1000136-4.
DOI
2014 Vabres, B., Le Bas-Bernardet, S., Riochet, D., Chérel, Y., Minault, D., Hervouet, J., . . . Vanhove, B. (2014). hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model. Xenotransplantation, 21(5), 431-443.
DOI Scopus35 WoS32 Europe PMC27
2014 Vassiliev, I., Tsui, A., Xian Kang, W., McIlfatrick, S., & Nottle, M. (2014). Effect of cytochalasin types on the production of heterozygous parthenogenetic porcine embryos and the isolation of putative parthenogenetic embryonic stem cells. Stem Cell Biology and Research, 1(1), 2-1-2-7.
DOI
2014 Hawthorne, W., Salvaris, E., Phillips, P., Hawkes, J., Liuwantara, D., Burns, H., . . . Cowan, P. (2014). Control of IBMIR in neonatal porcine islet xenotransplantation in baboons. American Journal of Transplantation, 14(6), 1300-1309.
DOI Scopus83 WoS78 Europe PMC74
2014 Stewart, J., Tarantal, A., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., . . . Kearns-Jonker, M. (2014). Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets. Xenotransplantation, 21(4), 341-352.
DOI Scopus4 WoS4 Europe PMC4
2014 Chen, Y., Stewart, J., Gunthart, M., Hawthorne, W., Salvaris, E., O'Connell, P., . . . Kearns-Jonker, M. (2014). Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation, 21(3), 244-253.
DOI Scopus28 WoS25 Europe PMC22
2013 Beebe, L., McIlfatrick, S., Vassiliev, I., & Nottle, M. (2013). Development of an improved porcine embryo culture medium for cloning, transgenesis and embryonic stem cell isolation. Cloning & Transgenesis, 2(2), 1-5.
DOI
2013 Pintore, L., Paltrinieri, S., Vadori, M., Besenzon, F., Cavicchioli, L., De Benedictis, G., . . . Castagnaro, M. (2013). Clinicopathological findings in non-human primate recipients of porcine renal xenografts: quantitative and qualitative evaluation of proteinuria. Xenotransplantation, 20(6), 449-457.
DOI Scopus14 WoS12 Europe PMC11
2013 Westall, G., Levvey, B., Salvaris, E., Gooi, J., Marasco, S., Rosenfeldt, F., . . . Cowan, P. (2013). Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation. Journal of Heart and Lung Transplantation, 32(11), 1123-1130.
DOI Scopus22 WoS21 Europe PMC17
2013 Naso, F., Gandaglia, A., Bottio, T., Tarzia, V., Nottle, M., d'Apice, A., . . . Gerosa, G. (2013). First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses. Xenotransplantation, 20(4), 252-261.
DOI Scopus112 WoS102 Europe PMC87
2013 Campbell, J., Lane, M., Vassiliev, I., & Nottle, M. (2013). Epiblast cell number and primary embryonic stem cell colony generation are increased by culture of cleavage stage embryos in insulin. Journal of Reproduction and Development, 59(2), 131-138.
DOI Scopus5 WoS4 Europe PMC4
2013 Campbell, J., Lane, M., Vassiliev, I., & Nottle, M. (2013). Use of insulin to increase epiblast cell number: towards a new approach for improving ESC isolation from human embryos. BioMed Research International, 2013, 1-7.
DOI Scopus2 WoS1 Europe PMC1
2013 Spiezia, L., Boldrin, M., Radu, C., Bulato, C., Bertini, D., Bon, M., . . . Simioni, P. (2013). Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney xenotransplantation. Xenotransplantation, 20(2), 89-99.
DOI Scopus12 WoS12 Europe PMC9
2013 Smits, R., Luxford, B., Mitchell, M., & Nottle, M. (2013). Embryo survival, but not first-parity litter size, is increased when gilts are fed diets supplemented with omega-3 fatty acids from fish oil. Animal Production Science, 53(1), 57-66.
DOI Scopus4 WoS3
2012 Campbell, J., Nottle, M., Vassiliev, I., Mitchell, M., & Lane, M. (2012). Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. Stem Cells and Development, 21(13), 2430-2441.
DOI Scopus21 WoS21 Europe PMC20
2012 Wheeler, D., Joseph, M., Mahamud, S., Aurand, W., Mohler, P., Pompili, V., . . . Gumina, R. (2012). Transgenic swine: expression of human CD39 protects against myocardial injury. Journal of Molecular and Cellular Cardiology, 52(5), 958-961.
DOI Scopus93 WoS84 Europe PMC84
2012 Gatford, K., Smits, R., Collins, C., De Blasio, M., Roberts, C., Nottle, M., . . . Owens, J. (2012). Maternal low-dose porcine somatotropin treatment in late gestation increases progeny weight at birth and weaning in sows but not in gilts. Journal of Animal Science, 90(5), 1428-1435.
DOI Scopus2 WoS2 Europe PMC1
2011 Smits, R., Luxford, B., Mitchell, M., & Nottle, M. (2011). Sow litter size is increased in the subsequent parity when lactating sows are fed diets containing n-3 fatty acids from fish oil. Journal of Animal Science, 89(9), 2731-2738.
DOI Scopus47 WoS43 Europe PMC30
2011 Athorn, R., Stott, P., Bouwman, E., Ashman, R., O'Leary, S., Nottle, M., & Langendijk, P. (2011). Direct ovarian-uterine transfer of progesterone increases embryo survival in gilts. Reproduction Fertility and Development, 23(7), 921-928.
DOI Scopus17 WoS16 Europe PMC11
2011 Campbell, J., Mitchell, M., Nottle, M., & Lane, M. (2011). Development of a mouse model for studying the effect of embryo culture on embryonic stem cell derivation. Stem Cells and Development, 20(9), 1578-1587.
DOI Scopus5 WoS4 Europe PMC4
2011 Vassiliev, I., Vassilieva, S., Truong, K., Beebe, L., McIlfatrick, S., Harrison, S., & Nottle, M. (2011). Isolation and in vitro characterization of putative porcine embryonic stem cells from cloned embryos treated with Trichostatin A. Cellular Reprogramming, 13(3), 205-213.
DOI Scopus25 WoS24 Europe PMC19
2011 Fisicaro, N., Londrigan, S., Brady, J., Salvaris, E., Nottle, M., O'Connell, P., . . . Cowan, P. (2011). Versatile co-expression of graft-protective proteins using 2A-linked cassettes. Xenotransplantation, 18(2), 121-130.
DOI Scopus29 WoS28 Europe PMC22
2011 Beebe, L., Bouwman, E., McIlfatrick, S., & Nottle, M. (2011). Piglets produced from in vivo blastocysts vitrified using the Cryologic Vitrification Method (solid surface vitrification) and a sealed storage container. Theriogenology, 75(8), 1453-1458.
DOI Scopus34 WoS32 Europe PMC29
2011 Mahamud, S., Wheeler, D. G., Jospeh, M., Dwyer, K. M., Nottle, M. B., Harrison, S. J., . . . Gumina, R. J. (2011). A Novel Transgenic Pig Model Overexpressing Ectonucleoside Triphosphate Diphosphohydrolase 1 ( entpd-1/cd39) Demonstrates Reduced Myocardial Injury. CIRCULATION, 124(21), 2 pages.
2011 Gock, H., Nottle, M., Lew, A. M., d'Apice, A. J. F., & Cowan, P. (2011). Genetic modification of pigs for solid organ xenotransplantation. Transplantation Reviews, 25(1), 9-20.
DOI Scopus27 WoS22 Europe PMC19
2010 Nottle, M. B., Vassiliev, I., O'Connel, P. J., D'Apice, A. J., & Cowan, P. J. (2010). On the need for porcine embryonic stem cells to produce Gal KO pigs expressing multiple transgenes to advance xenotransplantation research. Xenotransplantation, 17(6), 411-412.
DOI Scopus7 WoS6 Europe PMC4
2010 Gatford, K., Grupen, C., Campbell, R., Luxford, B., Smits, R., Owens, P., & Nottle, M. (2010). Reproductive responses to daily injections with porcine somatotropin before mating in gilts. Journal of Reproduction and Development, 56(5), 540-545.
DOI Scopus2 WoS2 Europe PMC1
2010 Vassiliev, I., Vassilieva, S., Beebe, L., McIlfatrick, S., Harrison, S., & Nottle, M. (2010). Development of culture conditions for the isolation of pluripotent porcine embryonal outgrowths from in vitro produced and in vivo derived embryos. Journal of Reproduction and Development, 56(5), 546-551.
DOI Scopus23 WoS22 Europe PMC15
2010 Vassiliev, I., Vassilieva, S., Beebe, L., Harrison, S., McIlfatrick, S., & Nottle, M. (2010). In vitro and in vivo characterization of putative porcine embryonic stem cells. Cellular Reprogramming, 12(2), 223-230.
DOI Scopus64 WoS65 Europe PMC48
2010 Gatford, K., Smits, R., Collins, C., Argent, C., De Blasio, M., Roberts, C., . . . Owens, J. (2010). Maternal responses to daily maternal porcine somatotropin injections during early-mid pregnancy or early-late pregnancy in sows and gilts. Journal of Animal Science, 88(4), 1365-1378.
DOI Scopus9 WoS9 Europe PMC6
2009 Beebe, L., McIlfatrick, S., & Nottle, M. (2009). Cytochalasin B and trichostatin A treatment postactivation improves In Vitro development of porcine somatic cell nuclear transfer embryos. Cloning and Stem Cells, 11(4), 477-482.
DOI Scopus32 WoS31 Europe PMC26
2009 Gatford, K., De Blasio, M., Roberts, C., Nottle, M., Kind, K., Van Wettere, W., . . . Owens, J. (2009). Responses to maternal GH or ractopamine during early-mid pregnancy are similar in primiparous and multiparous pregnant pigs. Journal of Endocrinology, 203(1), 143-154.
DOI Scopus19 WoS20 Europe PMC16
2009 Beebe, L., Vassiliev, I., McIlfatrick, S., & Nottle, M. (2009). Adding essential amino acids at a low concentration improves the development of in vitro fertilized porcine embryos. Journal of Reproduction and Development, 55(4), 373-377.
DOI Scopus15 WoS11 Europe PMC8
2009 Bagg, M., Nottle, M., Armstrong, D., & Grupen, C. (2009). Effect of follicle size and dibutyryl cAMP on the cAMP content and gap junctional communication of porcine prepubertal cumulus-oocyte complexes during IVM. Reproduction Fertility and Development, 21(6), 796-804.
DOI Scopus20 WoS21 Europe PMC14
2007 Bagg, M., Nottle, M., Armstrong, D., & Grupen, C. (2007). Relationship between follicle size and oocyte developmental competence in prepubertal and adult pigs. Reproduction Fertility and Development, 19(7), 797-803.
DOI Scopus97 WoS92 Europe PMC73
2007 Nottle, M., Beebe, L., Harrison, S., McIlfatrick, S., Ashman, R., O'Connell, P., . . . d'Apice, A. (2007). Production of homozygous α-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation, 14(4), 339-344.
DOI Scopus70 Europe PMC64
2007 Beebe, L., McIlfatrick, S., & Nottle, M. (2007). The effect of energy substrate concentration and amino acids on the in vitro development of preimplantation porcine embryos. Cloning and Stem Cells, 9(2), 206-215.
DOI Scopus12 WoS12 Europe PMC12
2007 Cowan, P., Nottle, M., & d'Apice, A. (2007). Molecular regulation of xenoreactivity. Current Opinion in Organ Transplantation, 12(1), 30-36.
DOI Scopus3 WoS3 Europe PMC3
2007 Beebe, L., McIlfatrick, S., Grupen, C., Boquest, A., Harrison, S., Faast, R., . . . Nottle, M. (2007). A comparison of two in vitro maturation media for use with adult porcine oocytes for adult somatic cell nuclear transfer. Cloning and Stem Cells, 9(4), 564-570.
DOI Scopus9 WoS8 Europe PMC6
2007 Nottle, M. B., Beebe, L. F. S., Harrison, S. J., Mcllfattric, S. M., Ashman, R. J., O'Connell, P. J., . . . d'Apice, A. J. F. (2007). Production of homozygous α-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. XENOTRANSPLANTATION, 14(4), 339-344.
DOI WoS67
2006 O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., & d'Apice, A. (2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation, 11(2), 174-179.
DOI Scopus2 WoS1
2006 Faast, R., Harrison, S., Beebe, L., McIlfatrick, S., Ashman, R., & Nottle, M. (2006). Use of adult mesenchymal stem cells isolated from bone marrow and blood for somatic cell nuclear transfer in pigs. Cloning and Stem Cells, 8(3), 166-173.
DOI Scopus70 WoS64 Europe PMC57
2006 Bagg, M., Nottle, M., Grupen, C., & Armstrong, D. (2006). Effect of dibutyryl cAMP on the cAMP content, meiotic progression, and developmental potential of in vitro matured pre-pubertal and adult pig oocytes. Molecular Reproduction and Development, 73(10), 1326-1332.
DOI Scopus60 WoS57 Europe PMC52
2005 Verma, P., Nottle, M. B., & Pralong, D. (2005). Nuclear transfer to oocytes and ES cells. CHROMOSOME RESEARCH, 13, 10-11.
2004 Harrison, S., Boquest, A., Grupen, C., Faast, R., Guildolin, A., Giannakis, C., . . . Nottle, M. (2004). An efficient method for production α(1,3)-galactosyltransferase gene knockout pigs. Cloning and Stem Cells, 6(4), 327-331.
DOI Scopus50 WoS43 Europe PMC36
2004 Nottle, M., Boquest, A., Harrison, S., Grupen, C., Faast, R., Ashman, R., & McIlfatrick, S. (2004). Transgenic perspectives in livestock science: a review. Australian Journal of Experimental Agriculture, 44(11), 1113-1117.
DOI Scopus2 WoS2
2004 Nagashima, H., Giannakis, C., Ashman, R., & Nottle, M. (2004). Sex differentiation and germ cell production in chimeric pigs produced by inner cell mass injection into blastocysts. Biology of Reproduction, 70(3), 702-707.
DOI Scopus41 WoS39 Europe PMC32
2004 Nottle, M., Beebe, L., Harrison, S., Faast, R., Moretta, M., & McIlfatrick, S. (2004). Future Directions for Mammalian Cloning. Journal of Reproduction and Development, 50(Supplement), J163.
2003 Cowan, P., Shinkel, T., Fisicaro, N., Godwin, J., Bernabeu, C., Almendro, N., . . . d'Apice, A. (2003). Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters. Xenotransplantation, 10(3), 223-231.
DOI Scopus26 WoS26 Europe PMC21
2003 Grupen, C., McIlfatrick, S., Ashman, R., Boquest, A., Armstrong, D., & Nottle, M. (2003). Relationship between donor animal age, follicular fluid steroid content and oocyte developmental competence in the pig. Reproduction Fertility and Development, 15(2), 81-87.
DOI Scopus60 WoS58 Europe PMC50
2002 Grupen, C., Nottle, M., & Nagashima, H. (2002). Calcium release at fertilization: Artificially mimicking the oocyte's response to sperm. Journal of Reproduction and Development, 48(4), 313-333.
DOI Scopus17 WoS17
2002 Nottle, M., d'Apice, A., Cowan, P., Boquest, A., Harrison, S., & Grupen, C. (2002). Transgenic perspectives in xenotransplantation, 2001. Xenotransplantation, 9(5), 305-308.
DOI Scopus9 WoS8 Europe PMC8
2002 Boquest, A., Grupen, C., Harrison, S., McIlfatrick, S., Ashman, R., d'Apice, A., & Nottle, M. (2002). Production of cloned pigs from cultured fetal fibroblast cells. Biology of Reproduction, 66(5), 1283-1287.
DOI Scopus134 WoS128 Europe PMC102
2002 Beebe, L., Cameron, R., Blackshaw, A., Higgins, A., & Nottle, M. (2002). Piglets born from centrifuged and vitrified early and peri-hatching blastocysts. Theriogenology, 57(9), 2155-2165.
DOI Scopus34 WoS30 Europe PMC28
2002 Harrison, S., Guidolin, A., Faast, R., Crocker, L., Giannakis, C., d'Apice, A., . . . Lyons, I. (2002). Efficient generation of [alpha](1,3) galactosyltransferase knockout porcine fetal fibroblasts for nuclear transfer. Transgenic Research, 11(2), 143-150.
DOI Scopus34 WoS29 Europe PMC27
2002 Grupen, C., Mau, J., McIlfatrick, S., Maddocks, S., & Nottle, M. (2002). Effect of 6-dimethylaminopurine on electrically activated in vitro matured porcine oocytes. Molecular Reproduction and Development, 62(3), 387-396.
DOI Scopus49 WoS46 Europe PMC37
2001 d'Apice, A., Nottle, M., & Cowan, P. (2001). Genetic modification for xenotransplantation: Transgenics and clones. Transplantation Proceedings, 33(7-8), 3053-3054.
DOI Scopus7 WoS4 Europe PMC4
2001 Nottle, M., Haskard, K., Verma, P., Du, Z., Grupen, C., McIlfatrick, S., . . . d'Apice, A. (2001). Effect of DNA concentration on transgenesis rates in mice and pigs. Transgenic Research, 10(6), 523-531.
DOI Scopus39 WoS32 Europe PMC24
2000 Cowan, P., Cowan, A., Barlow, H., Brown, A., Chen, C., Fisicaro, N., . . . d'Apice, A. (2000). Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation, 69(12), 2504-2515.
DOI Scopus191 WoS170 Europe PMC144
2000 Verma, P., Du, Z., Crocker, L., Faast, R., Grupen, C., McIlfatrick, S., . . . Nottle, M. (2000). In vitro development of porcine nuclear transfer embryos constructed using fetal fibroblasts. Molecular Reproduction and Development, 57(3), 262-269.
DOI Scopus30 WoS25 Europe PMC16
2000 Cameron, R., Beebe, L., Blackshaw, A., Higgins, A., & Nottle, M. (2000). Piglets born from vitrified early blastocysts using a simple technique. Australian Veterinary Journal, 78(3), 195-196.
DOI Scopus28 WoS26 Europe PMC21
2000 Grupen, C. G., Verma, P. J., Zhong Tao Du., McIlfatrick, S. M., Ashman, R. J., & Nottle, M. B. (2000). Activation of in vivo- and in vitro-derived porcine oocytes by using multiple electrical pulses. Reproduction Fertility and Development, 11(7-8), 457-462.
DOI Scopus27 WoS29 Europe PMC22
1999 Grupen, C. G., Du, Z. T., Verma, P. J., McIlfatrick, S. M., Ashman, R. J., & Nottle, M. B. (1999). Parthenogenetic development of porcine oocytes activated with multiple sets of electrical pulses. THERIOGENOLOGY, 51(1), 356.
DOI WoS1
1999 Verma, P. J., Du, Z. T., Grupen, C. G., Ashman, R. J., McIlfatrick, S. M., & Nottle, M. B. (1999). Effect of cell cycle synchronization on porcine nuclear transfer. THERIOGENOLOGY, 51(1), 215.
DOI WoS2
1999 Nottle, M. B., Verma, P. J., Du, Z. T., Grupen, C. G., McIlfatrick, S. M., Ashman, R. J., . . . d'Apice, A. J. F. (1999). Production of pigs expressing multiple transgenes for use in xenotransplantation studies. THERIOGENOLOGY, 51(1), 422.
DOI WoS4
1999 Du, Z. T., Verma, P. J., Crocker, L. A., Faast, R., Lyons, I. G., & Nottle, M. B. (1999). Development of nuclear transfer embryos using porcine fetal fibroblasts. THERIOGENOLOGY, 51(1), 201.
DOI WoS10
1999 Nagashima, H., Cameron, R. D. A., Kuwayama, M., Young, M., Beebe, L., Blackshaw, A. W., & Nottle, M. B. (1999). Survival of porcine delipated oocytes and embryos after cryopreservation by freezing or vitrification. Journal of Reproduction and Development, 45(2), 167-176.
DOI Scopus48
1998 Nottle, M. B., Verma, P. J., Du, Z. T., Ashman, R. J., Grupen, C. J., & MacIlfatrick, S. M. (1998). Superovulation of sows with eCG or FSH. THERIOGENOLOGY, 49(1), 381.
DOI WoS4
1998 Cowan, P. J., Shinkel, T. A., Aminian, A., Romanella, M., Wigley, P. L., Lonie, A. J., . . . D'Apice, A. J. F. (1998). High-level co-expression of complement regulators on vascular endothelium in transgenic mice: CD55 and CD59 provide greater protection from human complement-mediated injury than CD59 alone. Xenotransplantation, 5(3), 184-190.
DOI Scopus28 WoS25 Europe PMC20
1998 Nottle, M. B., Kleemann, D. O., Hocking, V. M., Grosser, T. I., & Seamark, R. F. (1998). Development of a nutritional strategy for increasing lamb survival in Merino ewes mated in late spring/early summer. Animal Reproduction Science, 52(3), 213-219.
DOI Scopus12 WoS11 Europe PMC4
1997 Grupen, C. G., Nagashima, H., & Nottle, M. B. (1997). Role of epidermal growth factor and insulin-like growth factor-I on porcine oocyte maturation and embryonic development in vitro. Reproduction Fertility and Development, 9(6), 571-575.
DOI Scopus67 WoS67 Europe PMC38
1997 Grupen, C., Nagashima, H., & Nottle, M. (1997). Asynchronous meiotic progression in porcine oocytes matured in vitro: a cause of polyspermic fertilization?. Reproduction, Fertility and Development, 9(2), 187-191.
DOI Scopus45 WoS42 Europe PMC29
1997 Nottle, M., Kleeman, D., Grosser, T., & Seamark, R. (1997). Evaluation of a nutritional strategy to increase ovulation rate in Merino ewes mated in late spring - early summer. Animal Reproduction Science, 47(4), 255-261.
DOI Scopus24 WoS24 Europe PMC12
1997 Nottle, M., Kleeman, D., & Seamark, R. (1997). Effect of previous undernutrition on the ovulation rate of Merino ewes supplemented with lupin grain. Animal Reproduction Science, 49(1), 29-36.
DOI Scopus30 WoS28 Europe PMC10
1997 Nagashima, H., Ashman, R., & Nottle, M. (1997). Nuclear transfer of porcine embryos using cryopreserved delipated blastomeres as donor nuclei. Molecular Reproduction and Development, 48(3), 339-343.
DOI Scopus29 WoS25 Europe PMC21
1997 Nottle, M., Nagashima, H., Verma, P., Du, Z., Grupen, C., Ashman, R., & MacIlfatrick, S. (1997). Developments in transgenic techniques in pigs. Journal of Reproduction and Fertility Supplement, 52, 237-244.
Scopus22 WoS20 Europe PMC10
1996 Kashiwazaki, N., Nagashima, H., Ashman, R., Grupen, C., & Nottle, M. (1996). Freezing of in vitro derived and in vitro pre-cultured porcine blastocysts: differences of the cryoprotective effect between glycerol and ethylene glycol. Journal of Reproduction and Development, 42(3), 193-197.
DOI
1996 Nagashima, H., Grupen, C., Ashman, R., & Nottle, M. (1996). Developmental competence of in vivo and in vitro matured porcine oocytes after subzonal sperm injection. Molecular Reproduction and Development, 45(3), 359-363.
DOI Scopus41 WoS40 Europe PMC29
1996 van Denderen, B., Pearse, M., Katerelos, M., Nottle, M., Du, Z. T., Aminian, A., . . . d'Apice, A. (1996). Expression of functional decay-accelerating factor (Cd55) in transgenic mice protects against human complement-mediated attack1. Transplantation, 61(4), 582-588.
DOI Scopus30 WoS31 Europe PMC27
1996 Tearle, R., Tange, M., Zannettino, Z., Katerelos, M., Shinkel, T., van Denderen, B., . . . d'Apice, A. (1996). The alpha-1,3-galactosyltransferase knockout mouse. Transplantation, 61(1), 13-19.
1996 Tearle, R. G., Tange, M. J., Zannettino, Z. L., Katerelos, M., Shinkel, T. A., Van Denderen, B. J. W., . . . D'Apice, A. J. F. (1996). The α-1,3-galactosyltransferase knockout mouse: Implications for xenotransplantation. Transplantation, 61(1), 13-19.
DOI Scopus281 WoS263 Europe PMC203
1995 Grupen, C. G., Nagashima, H., & Nottle, M. B. (1995). Cysteamine enhances in vitro development of porcine oocytes matured and fertilized in vitro. Biology of Reproduction, 53(1), 173-178.
DOI Scopus118 WoS108 Europe PMC71
1995 van Dendren, B., Somerville, C., Pearse, M., Nottle, M., Du, Z., Shinkel, T., & d'Apice, A. (1995). Expression of functional decay-accelerating factor in transgenic mice. Transplantation Proceedings, 27(6), 3567-3568.
Scopus1 WoS2 Europe PMC1
1995 Nagashima, H., Kashiwazaki, N., Ashman, R., & Nottle, M. (1995). Recent advances in cryopreservation of porcine embryos. Theriogenology, 41(1), 113-118.
DOI Scopus39 WoS40
1995 Nagashima, H., Kashiwazaki, N., Ashman, R., Grupen, C., & Nottle, M. (1995). Cryopreservation of porcine embryos. Nature, 374(6521), 416.
DOI Scopus226 WoS223 Europe PMC163
1995 Nagashima, H., Kashiwazaki, N., Ashman, R., & Nottle, M. (1995). Improved survival of porcine hatched blastocysts cryopreserved with glycerol and sucrose. Journal of Reproduction and Development, 41(2), 165-170.
DOI Scopus7
1994 Nagashima, H., Kashiwazaki, N., Ashman, R. J., Grupen, C. G., Seamark, R. F., & Nottle, M. B. (1994). Removal of cytoplasmic lipid enhances the tolerance of porcine embryos to chilling. Biology of Reproduction, 51(4), 618-622.
DOI Scopus195 WoS181 Europe PMC148
1990 Nottle, M. B., Seamark, R. F., & Setchell, P. (1990). Feeding lupin grain for six days prior to а cloprostenol-induced luteolysis can increase ovulation rate in sheep irrespective of when in the oestrous cycle supplementation commences. Reproduction Fertility and Development, 2(2), 189-192.
DOI Scopus26 WoS22 Europe PMC11
1988 Nottle, M. B., Hynd, P. I., Seamark, R. F., & Setchell, B. P. (1988). Increases in ovulation rate in lupin-fed ewes are initiated by increases in protein digested post-ruminally. Journal of Reproduction and Fertility, 84(2), 563-566.
DOI Scopus23 WoS24 Europe PMC12
1986 Sharpe, P. H., Gifford, D. R., Flavel, P. F., Nottle, M. B., & Armstrong, D. T. (1986). Effect of melatonin on postpartum anestrus in beef cows. Theriogenology, 26(5), 621-629.
DOI Scopus16 WoS18 Europe PMC4

Year Citation
2025 Salvaris, E. J., Fuller, E., Le, T., Fisicaro, N., McIlfatrick, S., Nottle, M. B., . . . Cowan, P. J. (2025). Preliminary Evaluation of Local Expression of a Human T Cell Depleting Monoclonal Antibody by Diliximab-hCD55-hCD59-Galtko Pig Islet Xenografts in Diabetic Mice and Baboons. In XENOTRANSPLANTATION Vol. 32 (pp. 1 page). WILEY.
2025 Hawthorne, W., Le, T., Salvaris, E., Fuller, E., Nottle, M. B., & Cowan, P. J. (2025). Advancing Cures for Type 1 Diabetes Using Flow Cytometry as a Guide for Safe and Efficacious Immunosuppression in Xenotransplantation. In XENOTRANSPLANTATION Vol. 32 (pp. 2 pages). WILEY.
2024 Saini, A., McPherson, N., & Nottle, M. (2024). GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR DURING IN VITRO OOCYTEMATURATION IMPROVES IMPLANTATION AND FETAL NUMBERS.. In FERTILITY AND STERILITY Vol. 122 (pp. E175). NETHERLANDS, Amsterdam: ELSEVIER SCIENCE INC.
DOI
2023 Thomas, A., Fuller, E., Salvaris, E., Nottle, M., Cowan, P. J., & Hawthorne, W. (2023). Optimising transgenic porcine neonatal islet cell cluster culture for use in pig-to-baboon xenotransplantation. In TRANSPLANTATION Vol. 107 (pp. 41). CA, San Diego: LIPPINCOTT WILLIAMS & WILKINS.
DOI
2021 Salvaris, E., Thomas, A., Byrne, N., Fisicaro, N., Nottle, M. B., Hawthorne, W. J., & Cowan, P. J. (2021). Characterization of transgenic pigs expressing an anti-Cd2 monoclonal antibody. A continuing quest for the ideal islet donor. In Proceedings of the Joint Congress of the International Xenotransplantation Association (IXA) and the Cell Transplant and Regenerative Medicine Society (CTRMS) as published in Xenotransplantation Vol. 28 (pp. 24). online: Wiley.
DOI
2018 Hawthorne, W., Burns, H., Chew, Y. V., Salvaris, E., Ayoubi, A., Hawkes, J., . . . Cowan, P. (2018). Long-Term Function of Genetically Modified Porcine Neonatal Islet Xenografts in Baboons. In TRANSPLANTATION Vol. 102 (pp. S390). Madrid, SPAIN: LIPPINCOTT WILLIAMS & WILKINS.
DOI
2016 Hawthorne, W. J., Hawkes, J., Salvaris, E., Chew, Y., Burns, H., Davies, S., . . . Cowan, P. (2016). Genetically modified porcine neonatal islet xenografts provide long-term survival in baboons. In TRANSPLANTATION Vol. 100 (pp. S445). LIPPINCOTT WILLIAMS & WILKINS.
2016 Salvaris, E., Fisicaro, N., Vasiliev, I., McIlfatrick, S., Nottle, M., Brady, J., . . . Cowan, P. (2016). Knock-in of anti-CD2 and human thrombomodulin transgenes into pig GGTA1 using CRISPR/Cas9. In TRANSPLANTATION Vol. 100 (pp. S237). LIPPINCOTT WILLIAMS & WILKINS.
2015 Hawthorne, W., Hawkes, J., Salvaris, E., Liuwantara, D., Chew, Y. V., Davies, S., . . . Cowan, P. (2015). LONG-TERM SURVIVAL OF GENETICALLY MODIFIED PORCINE NEONATAL ISLET XENOGRAFTS IN BABOONS.. In TRANSPLANTATION Vol. 99 (pp. S30). Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
2015 Salvaris, E., Vassiliev, I., McIlfatrick, S., Fisicaro, N., Brady, J., Hawthrone, W., . . . Cowan, P. (2015). GENERATION OF TRANSGENIC PIGS EXPRESSING A T CELL-DEPLETING ANTI-CD2 MONOCLONAL ANTIBODY.. In TRANSPLANTATION Vol. 99 (pp. S63). Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
2015 Fisicaro, N., Salvaris, E., Nottle, M., & Cowan, P. (2015). TARGETED TRANSGENE INSERTION IN PIG CELLS USING A HIGH FIDELITY CRISPR SYSTEM.. In TRANSPLANTATION Vol. 99 (pp. S62). Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
2015 Salvaris, E., Vassiliev, I., McIlfatrick, S., Fisicaro, N., Brady, J., Hawthrone, W., . . . Cowan, P. (2015). Generation of transgenic pigs expressing a T cell-depleting anti-CD2 monoclonal antibody. In XENOTRANSPLANTATION Vol. 22 (pp. S39-S40). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2015 Fisicaro, N., Salvaris, E., Nottle, M., & Cowan, P. (2015). Targeted transgene insertion in pig cells using a high fidelity CRISPR system. In XENOTRANSPLANTATION Vol. 22 (pp. S38-S39). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2015 Hawthorne, W., Hawkes, J., Salvaris, E., Liuwantara, D., Chew, Y. V., Davies, S., . . . Cowan, P. (2015). Long-term survival of genetically modified porcine neonatal islet xenografts in baboons. In XENOTRANSPLANTATION Vol. 22 (pp. S19). Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2014 Liuwantara, D., Chew, Y., Hawkes, J., Favaloro, E., Salvaris, E., Nottle, M., . . . Hawthorne, W. (2014). Genetic Modification of Porcine Neonatal Islets to Attenuate Complement Activation and Thrombin Generation.. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 14 (pp. 418). CA, San Francisco: WILEY-BLACKWELL.
2014 Liuwantara, D., Chew, Y., Hawkes, J., Favaloro, E., Salvaris, E., Nottle, M., . . . Hawthorne, W. (2014). Genetic Modification of Porcine Neonatal Islets to Attenuate Complement Activation and Thrombin Generation.. In TRANSPLANTATION Vol. 98 (pp. 418). CA, San Francisco: LIPPINCOTT WILLIAMS & WILKINS.
DOI
2012 Salvaris, E., Fisicaro, N., Harrison, S., Vassiliev, I., McIlfatrick, S., Nottle, M., . . . Cowan, P. (2012). Generation of Transgenic Pigs Co-Expressing Human Thrombomodulin and CD39. In TRANSPLANTATION Vol. 94 (pp. 784). LIPPINCOTT WILLIAMS & WILKINS.
DOI WoS1
2012 Salvaris, E., Brady, J., Fisicaro, N., Harrison, S., Vassiliev, I., McIlfatrick, S., . . . Cowan, P. (2012). Initial Steps in the Generation of Transgenic Pigs Expressing a T Cell-Depleting Monoclonal Antibody. In TRANSPLANTATION Vol. 94 (pp. 778). LIPPINCOTT WILLIAMS & WILKINS.
DOI
2012 Salvaris, E., Brady, J., Fisicaro, N., Harrison, S., Vassiliev, I., McIlfatrick, S., . . . Cowan, P. (2012). Initial Steps in the Generation of Transgenic Pigs Expressing a T Cell-Depleting Monoclonal Antibody. In TRANSPLANTATION Vol. 94 (pp. 99). LIPPINCOTT WILLIAMS & WILKINS.
DOI
2011 Salvaris, E., Fisicaro, N., Harrison, S., Nottle, M., Robson, S., d'Apice, A., & Cowan, P. (2011). Expression of human thrombomodulin in GTKO/hCD55-hCD59-HTF pigs. In XENOTRANSPLANTATION Vol. 18 (pp. 296). Miami, FL: WILEY-BLACKWELL.
WoS3
2011 Hawthorne, W. J., Phillips, P., Salvaris, E., Hawkes, J., Barlow, H., Farrell, P., . . . O'Connell, P. J. (2011). Gal-deficient porcine neonatal islets that express human CD55 and CD59 are protected from IBMIR in a baboon model. In XENOTRANSPLANTATION Vol. 18 (pp. 275). Miami, FL: WILEY-BLACKWELL.
2011 Vadori, M., Daha, M., Klar, N., Besenzon, F., Baldan, N., Cavicchioli, L., . . . Cozzi, E. (2011). Study of complement activation in a life supporting pig to primate xenotransplantation model using GAL KO pigs. In XENOTRANSPLANTATION Vol. 18 (pp. 274). Miami, FL: WILEY-BLACKWELL.
2011 Pintore, L., Paltrinieri, S., Vadori, M., Besenzon, F., Cavicchioli, L., Cozzi, E., . . . Castagnaro, M. (2011). Quantitative and qualitative evaluation of proteinuria in non human primates recipients of porcine xenografts. In XENOTRANSPLANTATION Vol. 18 (pp. 314). Miami, FL: WILEY-BLACKWELL.
2009 Cozzi, E., Simioni, P., Nottle, M. B., Vadori, M., De Benedictis, G. M., Baldan, N., . . . Cowan, P. J. (2009). Preliminary study in a life supporting pig to primate xenotransplantation model using GAL KO pigs transgenic for human CD39, CD55, CD59 and fucosyltransferase. In XENOTRANSPLANTATION Vol. 16 (pp. 544). Venice, ITALY: WILEY-BLACKWELL PUBLISHING, INC.
WoS4
2009 Le Bas-Bernardet, S., Tillou, X., Poirier, N., Dilek, N., Leroux, S., Chatelais, M., . . . Blancho, G. (2009). First xenotransplantations of GAL KO, CD55, CD59, CD39, HT transgenic pig kidneys in baboons. In XENOTRANSPLANTATION Vol. 16 (pp. 543-544). Venice, ITALY: WILEY-BLACKWELL PUBLISHING, INC.
WoS2
2009 Salvaris, E., Fisicaro, N., Harrison, S., Nottle, M., Lew, A., Robson, S., . . . Cowan, P. (2009). Multi-gene Constructs to Accelerate the Generation of Multi-transgenic GalT knockout pigs. In XENOTRANSPLANTATION Vol. 16 (pp. 373). Venice, ITALY: WILEY-BLACKWELL PUBLISHING, INC.
WoS1
2009 Salvaris, E., Hawthorne, W. J., Peirce, S., Barlow, H., Stewart, A., Zhang, X. -M., . . . Cowan, P. (2009). Improved survival of GalT KO/hCD55-hCD59 pig renal xenografts in non-immunosuppressed baboons. In XENOTRANSPLANTATION Vol. 16 (pp. 358). Venice, ITALY: WILEY-BLACKWELL PUBLISHING, INC.
WoS3
2007 Salvaris, E., Harrison, S., Beebe, L., Dwyer, K., Crikis, S., Hawthorne, W., . . . Cowan, P. (2007). Generation of a Gal knockout pig expressing human CD39. In XENOTRANSPLANTATION Vol. 14 (pp. 417-418). Minneapolis, MN: BLACKWELL PUBLISHING.
WoS4
2007 Hawthorne, W. J., Simond, D. M., O'Hara, J., Patel, A. T., Moyle, K., Waite, K., . . . O'Connell, P. J. (2007). Deletion of GAL and expression of CD39 in porcine neonatal islets inhibits the instant blood-mediated in ammatory reaction. In XENOTRANSPLANTATION Vol. 14 (pp. 417). MN, Minneapolis: BLACKWELL PUBLISHING.
2007 Gatford, K., De Blasio, M., Harland, M., Roberts, C., Heinemann, G., Nottle, M., . . . Owens, J. (2007). Effects of maternal somatotropin injections or feeding ractopamine in early-mid pregnancy in gilts and sows -UTV-AC-8/05. In J. Paterson, & J. Barker (Eds.), Proceedings of Manipulating Pig Production XI (pp. 1). Victoria: Australasian Pig Science Association.
2006 Hawthorne, W. J., Patel, A., O'Hara, J., Burgess, J., Akima, S., Salvaris, E., . . . O'Connell, P. J. (2006). Elimination of the α Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. In IMMUNOLOGY AND CELL BIOLOGY Vol. 84 (pp. A1). AUSTRALIA, Australian Acad Sci, Canberra: BLACKWELL PUBLISHING.
DOI
2005 Bagg, M. A., Nottle, M. B., Armstrong, D. T., & Grupen, C. G. (2005). Differences in pre-pubertal and adult oocyte developmental competence is correlated with oocyte cAMP content in the pig.. In BIOLOGY OF REPRODUCTION (pp. 236). Ctr Rech Biol Reproduct, Quebec City, CANADA: SOC STUDY REPRODUCTION.
WoS2
2003 Nottle, M., Beebe, L., Harrison, S., & Faast, R. (2003). A review - new reproductive technologies for production and research in the pig. In J. Paterson (Ed.), Proceedings of the Ninth Biennial Conference of the Australasian Pig Science Association (Inc.) (APSA) (pp. 43-49). Werribee, Victoria, Australia: Australasian Pig Science Association (Inc.).
2001 Nottle, M., Boquest, A., Harrison, S., Grupen, C., Tolstochev, P., Cowan, P., & d'Apice, A. (2001). Xenotransplantation. A possible solution to the donor organ shortage?. In R. Baker, M. Fisher, & P. Hemsworth (Eds.), Proceedings of Farm animals in research - can we meet the demands of ethics, welfare, science and industry? (pp. 69-72). Adelaide, Australia.
2001 Harrison, S., Guidolin, A., Faast, R., Crocker, L., Boquest, A., Grupen, C., . . . Nottle, M. (2001). Towards the generation of a Gal knockout pig: successful use of porcine fetal fibroblasts for nuclear transfer and gene targeting. In XENOTRANSPLANTATION Vol. 8 (pp. 27). MUNKSGAARD INT PUBL LTD.
2000 Cowan, P. J., Goodman, D. J., Aminian, A., Brown, A., Barlow, H., Shinkel, T. A., . . . d'Apice, A. J. (2000). Disseminated complicates transgenic pig renal xenotransplantation in non-immunosuppressed baboons.. In TRANSPLANTATION Vol. 69 (pp. S419). LIPPINCOTT WILLIAMS & WILKINS.
WoS1
1999 Nottle, M. B., Nagashima, H., Verma, P. J., Du, Z. T., Grupen, C. G., McIlfatrick, S. M., . . . Robins, A. J. (1999). Production and analysis of transgenic pigs containing a metallothionein porcine growth hormone gene construct. In J. D. Murray, G. B. Anderson, A. M. Oberbauer, & M. M. McGloughlin (Eds.), TRANSGENIC ANIMALS IN AGRICULTURE (pp. 145-156). CA, TAHOE CITY: CABI PUBLISHING-C A B INT.
WoS31

Year Citation
2024 Hawthorne, W., Salvaris, E., Fuller, E., Le, T., Nottle, M., & Cowan, P. J. (2024). Xenotransplantation cures diabetes using local immunosuppression to protect transgenic porcine neonatal islet cell xenografts in the diabetic baboon model. Poster session presented at the meeting of Abstracts of the 30th International Congress of The Transplantation-Society (TTS2024), as published in Transplantation. Istanbul, TURKEY: Lippincott Williams & Wilkins.
DOI
2023 Salvaris, E., Fisicaro, N., Mcilfatrick, S., Thomas, A., Fuller, E., Lew, A. M., . . . Cowan, P. J. (2023). Evaluation of expression of a human T-cell depleting monoclonal antibody in islets and other tissues of transgenic pigs. Poster session presented at the meeting of Abstracts of the IPITA-IXA-CTRMA Joint Congress, as published in Transplantation. CA, San Diego: Lippincott Williams & Wilkins.
DOI
2022 Hawthorne, W. J., Salvaris, E., Hu, M., Lew, A., Nottle, M. B., O'Connell, P. J., & Cowan, P. J. (2022). Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons. Poster session presented at the meeting of TRANSPLANTATION. ELECTR NETWORK: LIPPINCOTT WILLIAMS & WILKINS.
2022 Hawthorne, W., Thomas, A., Salvaris, E., Byrne, N., Nottle, M., & Cowan, P. J. (2022). Review of the Safety and Efficacy of Immunosuppression in the Pig-To-Nonhuman Primate Islet Xenotransplantation Model. Poster session presented at the meeting of TRANSPLANTATION. ELECTR NETWORK: LIPPINCOTT WILLIAMS & WILKINS.
2019 Salvaris, E., Fisicaro, N., McIlfatrick, S., Vassiliev, I., Lew, A. M., Hawthorne, W. J., . . . Cowan, P. J. (2019). GGTA1 knock-in pigs expressing the anti-CD2 monoclonal antibody diliximab from the porcine insulin promoter. Poster session presented at the meeting of Xenotransplantation. Munich, Germany: Wiley.
2019 Fisicaro, N., Salvaris, E. J., Philip, G. K., Wakefield, M. J., Nottle, M. B., Hawthorne, W. J., & Cowan, P. (2019). FokI-dCas9 mediates high-fidelity genome editing in pigs. Poster session presented at the meeting of Xenotransplantation. Munich, Germany: Wiley.
DOI
2017 Hawthorne, W., Chew, Y. V., Salvaris, E., Hawkes, J., Burns, H., Ayoubi, A., . . . Cowan, P. (2017). >12 Month function of genetically modified porcine neonatal islet xenografts in baboons. Poster session presented at the meeting of XENOTRANSPLANTATION. Baltimore, MA: WILEY.
2017 Salvaris, E., McIlfatrick, S., Fisicaro, N., Vassiliev, I., Brady, J., Lew, A., . . . Cowan, P. (2017). Generation of anti-CD2 mAb-expressing GGTA1 knock-in pigs using a high fidelity CRISPR/Cas9 system. Poster session presented at the meeting of XENOTRANSPLANTATION. Baltimore, MA: WILEY.
2015 Hawthorne, W., Salvaris, E., Hawkes, J., Chew, Y. V., Davies, S., Barlow, H., . . . Cowan, P. (2015). Enhanced survival of GalT KO/hCD55-hCD59 pig renal xenografts in baboons. Poster session presented at the meeting of XENOTRANSPLANTATION. Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2015 Hawthorne, W., Salvaris, E., Hawkes, J., Chew, Y. V., Davies, S., Barlow, H., . . . Cowan, P. (2015). ENHANCED SURVIVAL OF GALT KO/HCD55-HCD59 PIG RENAL XENOGRAFTS IN BABOONS. Poster session presented at the meeting of TRANSPLANTATION. Melbourne, AUSTRALIA: LIPPINCOTT WILLIAMS & WILKINS.
WoS1
2014 Cowan, P. J., Hawthorne, W. J., Lew, A. M., O'Connell, P. J., Nottle, M. B., Robson, S. C., & d'Apice, A. J. F. (2014). Genetic modification of source pigs. Poster session presented at the meeting of XENOTRANSPLANTATION. Osaka, JAPAN: WILEY-BLACKWELL.
2013 Hawthorne, W. J., Phillips, P., Salvaris, E. J., Hawkes, J., Liuwantara, D., Barlow, H., . . . O'Connell, P. J. (2013). Porcine neonatal islet cell clusters that express human CD55-CD59 with Gal KO prevent thrombosis in a pre-clinical baboon study. Poster session presented at the meeting of XENOTRANSPLANTATION. Osaka, JAPAN: WILEY-BLACKWELL.
2013 Stewart, J. M., Yan, C., Gunthart, M., Tarantal, A. F., Lee, C., Appleby, N. C., . . . Kearns-Jonker, M. (2013). The application of chimerism, small molecule inhibitors, and anti-idiotypic single chain antibodies to inhibit anti-non-gal xenoantibody responses. Poster session presented at the meeting of XENOTRANSPLANTATION. Osaka, JAPAN: WILEY-BLACKWELL.
2013 Liuwantara, D., Phillips, P., Favaloro, E., Salvaris, E. J., Hawkes, J., Brady, J., . . . Hawthorne, W. J. (2013). Deciphering the mechanistic pathways of the instant blood mediated inflammatory reaction against porcine neonatal islet cells. Poster session presented at the meeting of Abstracts of the Joint Congress of IXA and Organ Transplantation in ABO-incompatible and Hyperimmunized Recipients, as published in Xenotransplantation. Osaka, Japan: Wiley-Blackwell.
DOI
2013 Vadori, M., Baldan, N., Besenzon, F., Fante, F., Boldrin, M., Cavicchioli, L., . . . Cozzi, E. (2013). Life supporting pig-to-primate xenotransplantation model using transgenic GalT KO pigs: The Padua experience. Poster session presented at the meeting of XENOTRANSPLANTATION. Osaka, JAPAN: WILEY-BLACKWELL.
Research Funding
International
2017

 		 Genetic modification to protect pig islets from T cell-mediated xenogeneic rejection Cowan PJ, Hawthorne H, Nottle MB Juvenile Diabetes Research Foundation US1.24 million
2016 Vascularised Biodegradable Temporizing Matrix as an Alternative Site for Islet Transplantation. Coates PTH, S Grey,….Nottle MB Juvenile Diabetes Research Foundation US750,000
2013-2014 Using embryonic stem cells to produce multitransgenic pigs MB Nottle Research Development Agency. South Korea US200,00
National
2021 Improving the fertility of extended semen  MB Nottle and NO McPherson  Australasian Pork Research Institute Limited  75,000
2019-2023  Transplantation of pig islets to treat type 1 diabetes  PJ Cowan, WJ Hawthorne, MB Nottle, Shounan Y  NHMRC 2.347 million 
2016   MB Nottle BioSA  Establishment of ICMStem Pty Ltd startup 43,000
2016-2017 Development of Cytochrome b5 (CYB5A) as a selection marker for boar taint MB Nottle, Hiendleder SG. CRC for High Integrity Pork. 70,000
2015-2016 Development of the  thyroid hormone deiodinase gene DI03 as a selection marker for early embryonic loss MB Nottle. Australian Pork Limited 196,000
2014-2018 Manipulating the balance of effector and regulatory T cells to promote islet xenograft survival Cowan PJ,  Nottle MB,  Hawthorne W, Shounan Y NHMRC Project Grant 1.532 million
2013- 2017 Using porcine embryonic stem cells to advance  xenotransplantation and human stem cell research to the clinic.   National Health & Medical Research Council (NHMRC) Senior Research Fellowship 615,000
2013-2016 Towards Pig to human kidney transplantation PJ Cowan (St Vincents Hospital) MB Nottle, WJ Hawthorne (Westmead Millennium Institute). NHMRC Project Grant APP1046152 1.086 million
2012 Project I D 7A-133 Reducing early embryonic loss. MB Nottle CRC Internationally Competitive Pork Industry. 50,000
2009-2012 Preclinical studies in xenotransplantation. PJ Cowan (St Vincents Hospital Melbourne), AJF d’Apice (St Vincents Hospital Melbourne), MB Nottle. NHMRC Project Grant. 558408 1.172 million
2008-2012 Which transgenic pig will be used for islet transplantation into humans? PJ  O’Connell  (Westmead Millennium Institute), AJF d’Apice (St Vincents Hospital) , PJ Cowan (St Vincents Hospital),  AM Lew (WEHI), MB Nottle, SJ Robson  (Harvard Medical School, Boston, USA). NHMRC/JDRF special program grant in Type 1 Diabetes 447718 3 million
Teaching
Undergraduate teaching
2018-present  Course Coordinator Reproductive Health Matters, Bachelor of Health and Medical Sciences, Faculty of Health and Medical Sciences.
2018-present  Course Coordinator Reproductive  Biology, Bachelor Health and Medical Sciences , Faculty of Health and Medical Sciences  
2016-2018   Lectured on various aspects of reproductive physiology in Comparative Reproductive Biology III, Bachelor of Health Sciences,  Faculty of Health Sciences.
2012-2015 Conducted student-led  tutorials   in stem cells as part of the Masters Biotechnology (Biomedical Sciences) course in the School of Molecular Biosciences in the Faculty of Sciences.
2003 - present Lectured on various aspects of animal  biotechnology in  Animal Biotechnology III School of Animal and Veterinary Sciences, Faculty of Sciences.
1992 - 2018  Lectured on reproductive physiology and ran student led tutorials on stem cells in Human Reproductive Health III, Bachelor of Health Sciences, Faculty of Health Sciences.

Date Role Research Topic Program Degree Type Student Load Student Name
2024 Co-Supervisor Future-Proofing Australia's Pig Industry: Preserving Genetic Diversity through Robust Gamete Cryopreservation Protocol for Porcine Biobanking Doctor of Philosophy Doctorate Full Time Ms Rosa Angelica Nunez Vela Molina
2024 Co-Supervisor Future-Proofing Australia's Pig Industry: Preserving Genetic Diversity through Robust Gamete Cryopreservation Protocol for Porcine Biobanking Doctor of Philosophy Doctorate Full Time Ms Rosa Angelica Nunez Vela Molina
2023 Co-Supervisor The Role of MicroRNA-30 in Preimplantation Embryo Development and offspring Traits in Mammals Doctor of Philosophy Doctorate Full Time Miss Oluwabunmi Ifedunni Olatunji
2023 Co-Supervisor Understanding the contribution of sperm non-coding RNA in early embryogenesis. Doctor of Philosophy Doctorate Full Time Mr Joshua Caryl Deluao
2023 Co-Supervisor The Role of MicroRNA-30 in Preimplantation Embryo Development and offspring Traits in Mammals Doctor of Philosophy Doctorate Full Time Miss Oluwabunmi Ifedunni Olatunji
2023 Co-Supervisor Understanding the contribution of sperm non-coding RNA in early embryogenesis. Doctor of Philosophy Doctorate Full Time Mr Joshua Caryl Deluao
2020 Principal Supervisor Improving in vitro maturation of oocytes by bringing research together: can we get synergy? Doctor of Philosophy Doctorate Part Time Ms Annie Louise Whitty
2019 Co-Supervisor Respiratory nurse management in people with chronic obstructive pulmonary disease Doctor of Philosophy Doctorate Part Time Mrs Karen Stacy Royals
2019 Co-Supervisor Respiratory nurse management in people with chronic obstructive pulmonary disease Doctor of Philosophy Doctorate Part Time Mrs Karen Stacy Royals

Date Role Research Topic Program Degree Type Student Load Student Name
2019 - 2019 Principal Supervisor Best-Practice Evidence Based Medicine for the Effective Management of Chronic Obstructive Pulmonary Disease (COPD) Doctor of Philosophy Doctorate Full Time Dr Zoe Antonia Kopsaftis
2019 - 2021 Co-Supervisor Management of Bronchiectasis: A Tertiary Health Care Perspective Master of Philosophy (Clinical Science) Master Part Time Mrs Kathryn Anne Lawton
2018 - 2025 Principal Supervisor THE EFFECT OF GM-CSF ON MAMMALIAN OOCYTE IN VITRO MATURATION (IVM) Doctor of Philosophy Doctorate Full Time Mr Anmol Saini
2017 - 2019 Principal Supervisor Insight into Appetite and Blood Glucose Regulation in Anorexia Nervosa and Health: Examining Gastrointestinal Changes in Starvation and with Short-term Refeeding Doctor of Philosophy Doctorate Part Time Ms Gabriella Alexandra Heruc
2010 - 2013 Co-Supervisor Culturing Embryos from the Cleavage to Blastocyst Stage; an Opportunity to Improve Pluripotency and Embryonic Stem Cell Generation Efficiency Doctor of Philosophy Doctorate Full Time Dr Jared Campbell
2009 - 2012 Principal Supervisor The Functional Role and Requirement for Long-Chain Omega-3 Polyunsaturated Fatty Acids in Breeding Gilts and Sows Doctor of Philosophy Doctorate Part Time Mr Robert John Christian Smits
2004 - 2007 Principal Supervisor Factors Affecting the Developmental Competence of Pig Oocytes Matured In Vitro Doctor of Philosophy Doctorate Full Time Dr Melanie Bagg

Date Role Committee Institution Country
2015 - ongoing Member Adelaide Medical School Executive University of Adelaide -
2015 - ongoing Member Adelaide Medical School Research Committee University of Adelaide -
2015 - ongoing Member Medical School Research Education Committee University of Adelaide -
2012 - 2016 Representative Research Education Development Committee University of Adelaide -
2012 - 2016 Representative International Scholarships Committee University of Adelaide -
2012 - 2016 Representative Domestic Scholarships Committee University of Adelaide -
2012 - 2016 Member Faculty Health Sciences Research Executive - -
2012 - 2016 Member Faculty Health Sciences Research Executive - -
2012 - 2016 Member Faculty of Health Sciences Research Committee - -
2012 - 2014 Representative Student Matters Subcommittee University of Adelaide -
2010 - 2015 Member Research Committee School of Paediatrics and Reproductive Health - -
2010 - ongoing Representative Research and Development Committee - -
2010 - 2013 Member Honours Committee, School of Paediatrics and Reproductive Health - -
2010 - 2012 Member ARI Commercial Opportunity Panel - -
2009 - ongoing Member JDRF The Australian Type 1 Diabetes Research Directions Workshop - -
2008 - ongoing Member NHMRC Workshop on the Risks and Benefits of xenotransplantation in Australia. - -
2008 - ongoing Member International Society of Stem Cell Research - -
2008 - 2011 Member Robinson Institute Management Committee - -
2004 - 2011 Member Postgraduate Committee, School of Paediatrics and Reproductive Health - -
1997 - ongoing Member Asian Reproductive Biotechnology Society - -
1992 - ongoing Member International Embryo Transfer Society - -
1992 - ongoing Member Australasian Pig Science Association - -
1985 - ongoing Member Australian Society for Reproductive Biology - -

Date Institution Department Organisation Type Country
2003 - ongoing Australian Research Council and the National Health & Medical Research Council - - -
1990 - ongoing Various - - -

Date Role Editorial Board Name Institution Country
2000 - ongoing Member Editorial Board, Reproduction and Development - Japan

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