Principal Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Associate Professor Mark Nottle
The Reproductive Biotechnology Group has an international reputation in the general areas of reproductive biology and the development of associated technologies for biomedical and agricultural applications. In collaboration with a number of university, institute and hospital research groups in Australia as well as overseas, current research is focused in the general area of regenerative medicine in particular stem cell research, as well as the development of assisted reproductive technologies including in vitro oocyte maturation.
Isolation and characterisation of a new stem cell type
Current research in the Laboratory is focussed on characterising a new embryonic stem cell isolated by us .This breakthrough will impact on the development of cell based therapies for a range of diseases including Type 1 diabetes for which no effective treatment currently exists as well as having other applications such as drug discovery . This cell type is patent protected and we have formed a Company to commercialise this research.
Improving Human IVF outcomes
Other research being undertaken in the Laboratory includes developing new approaches to human IVF aimed at overcoming the need for hormonal stimulation which is around half the cost of an IVF cycle. This involves adding hormones and growth factors found in the follicle to in vitro oocyte maturation media and examining embryo development.
Biomarkers for overcoming early embryonic loss
Industry sponsored research includes the development of molecular selection markers for improving livestock growth and reproductive performance. The later of which may has implications for overcoming early embryonic loss and recurrent miscarriage in humans.
Honours and PhD projects are available in al of these areas.
||Genetic modification to protect pig islets from T cell-mediated xenogeneic rejection||Cowan PJ, Hawthorne H, Nottle MB||Juvenile Diabetes Research Foundation||US1.24 million|
|2016||Vascularised Biodegradable Temporizing Matrix as an Alternative Site for Islet Transplantation.||Coates PTH, S Grey,….Nottle MB||Juvenile Diabetes Research Foundation||US750,000|
|2013-2014||Using embryonic stem cells to produce multitransgenic pigs||MB Nottle||Research Development Agency. South Korea||US200,00|
|2016||MB Nottle||BioSA Establishment of ICMStem Pty Ltd startup||43,000|
|2016-2017||Development of Cytochrome b5 (CYB5A) as a selection marker for boar taint||MB Nottle, Hiendleder SG.||CRC for High Integrity Pork.||70,000|
|2015-2016||Development of the thyroid hormone deiodinase gene DI03 as a selection marker for early embryonic loss||MB Nottle.||Australian Pork Limited||196,000|
|2014-2018||Manipulating the balance of effector and regulatory T cells to promote islet xenograft survival||Cowan PJ, Nottle MB, Hawthorne W, Shounan Y||NHMRC Project Grant||1.532 million|
|2013- 2017||Using porcine embryonic stem cells to advance xenotransplantation and human stem cell research to the clinic.||National Health & Medical Research Council (NHMRC) Senior Research Fellowship||615,000|
|2013-2016||Towards Pig to human kidney transplantation||PJ Cowan (St Vincents Hospital) MB Nottle, WJ Hawthorne (Westmead Millennium Institute).||NHMRC Project Grant APP1046152||1.086 million|
|2012||Project I D 7A-133 Reducing early embryonic loss.||MB Nottle||CRC Internationally Competitive Pork Industry.||50,000|
|2009-2012||Preclinical studies in xenotransplantation.||PJ Cowan (St Vincents Hospital Melbourne), AJF d’Apice (St Vincents Hospital Melbourne), MB Nottle.||NHMRC Project Grant. 558408||1.172 million|
|2008-2012||Which transgenic pig will be used for islet transplantation into humans?||PJ O’Connell (Westmead Millennium Institute), AJF d’Apice (St Vincents Hospital) , PJ Cowan (St Vincents Hospital), AM Lew (WEHI), MB Nottle, SJ Robson (Harvard Medical School, Boston, USA).||NHMRC/JDRF special program grant in Type 1 Diabetes 447718||3 million|
|2016 - present||Lectured on various aspects of reproductive physiology in Comparative Reproductive Biology III, Bachelor of Health Sciences, Faculty of Health Sciences.|
|2012-2015||Conducted student-led tutorials in stem cells as part of the Masters Biotechnology (Biomedical Sciences) course in the School of Molecular Biosciences in the Faculty of Sciences.|
|2003 - present||Lectured on various aspects of animal biotechnology in Animal Biotechnology III School of Animal and Veterinary Sciences, Faculty of Sciences.|
|1992 - present||Lectured on reproductive physiology and ran student led tutorials on stem cells in Human Reproductive Health III, Bachelor of Health Sciences, Faculty of Health Sciences.|
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