Mark Nottle

Associate Professor Mark Nottle

Principal Research Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Associate Professor Mark Nottle
Research Interests:

The Reproductive Biotechnology Group has an international reputation in the general areas of reproductive biology and the development of associated technologies for biomedical and agricultural applications. In collaboration with a number of university, institute and hospital research groups in Australia as well as overseas, current research is focused in the general area of regenerative medicine in particular stem cell research, as well as the development of assisted reproductive technologies including in vitro oocyte maturation.

Isolation  and characterisation of a new  stem cell type

Current research in the Laboratory is  focussed on characterising a new embryonic  stem cell isolated by us .This breakthrough will  impact on the development of cell based therapies for a range of diseases including Type 1 diabetes  for which no effective treatment currently exists as well as having other applications such as drug discovery . This cell type is patent protected and we have formed  a Company to commercialise   this research.

Improving Human IVF outcomes

Other research being undertaken in the Laboratory  includes developing new approaches to human IVF aimed at overcoming the need for hormonal stimulation which is around half the cost of an IVF cycle. This involves adding hormones and growth factors found in the follicle to  in vitro oocyte maturation media and examining embryo development.

Biomarkers for  overcoming early embryonic loss

Industry sponsored research includes the development of molecular selection markers for improving livestock growth  and reproductive performance. The later of  which may has  implications for overcoming early embryonic loss and recurrent miscarriage in humans.

Honours and PhD projects are available in al of these areas.

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  • Appointments

    Date Position Institution name
    2016 Director ICMStemcell Pty Ltd
    2015 Deputy Head, Adelaide Medical School University of Adelaide, Adelaide
    2013 - 2015 Acting Head, School of Paediatrics and Reproductive Health University of Adelaide, Adelaide
    2012 - 2016 Convenor, Higher Degrees by Research University of Adelaide, Adelaide
    2007 - 2011 Director University of Adelaide, Adelaide
    2005 NHMRC Senior Research Fellow University of Adelaide, Adelaide
    2003 Associate Professor University of Adelaide, Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2015 Fellowship Fellow, Society for Reproductive Biology.
  • Education

    Date Institution name Country Title
    1990 University of Adelaide, Adelaide Australia Doctor of Philosophy
    1982 University of Adelaide, Adelaide Australia Bachelor of Agricultural Science Honours (First Class)
    1981 University of Adelaide, Adelaide Australia Bachelor of Agricultural Science
  • Research Interests

Research Funding
International
2017
 
Genetic modification to protect pig islets from T cell-mediated xenogeneic rejection Cowan PJ, Hawthorne H, Nottle MB Juvenile Diabetes Research Foundation US1.24 million
2016 Vascularised Biodegradable Temporizing Matrix as an Alternative Site for Islet Transplantation. Coates PTH, S Grey,….Nottle MB Juvenile Diabetes Research Foundation US750,000
2013-2014 Using embryonic stem cells to produce multitransgenic pigs MB Nottle Research Development Agency. South Korea US200,00
National
2016   MB Nottle BioSA  Establishment of ICMStem Pty Ltd startup 43,000
2016-2017 Development of Cytochrome b5 (CYB5A) as a selection marker for boar taint MB Nottle, Hiendleder SG. CRC for High Integrity Pork. 70,000
2015-2016 Development of the  thyroid hormone deiodinase gene DI03 as a selection marker for early embryonic loss MB Nottle. Australian Pork Limited 196,000
2014-2018 Manipulating the balance of effector and regulatory T cells to promote islet xenograft survival Cowan PJ,  Nottle MB,  Hawthorne W, Shounan Y NHMRC Project Grant 1.532 million
2013- 2017 Using porcine embryonic stem cells to advance  xenotransplantation and human stem cell research to the clinic.   National Health & Medical Research Council (NHMRC) Senior Research Fellowship 615,000
2013-2016 Towards Pig to human kidney transplantation PJ Cowan (St Vincents Hospital) MB Nottle, WJ Hawthorne (Westmead Millennium Institute). NHMRC Project Grant APP1046152 1.086 million
2012 Project I D 7A-133 Reducing early embryonic loss. MB Nottle CRC Internationally Competitive Pork Industry. 50,000
2009-2012 Preclinical studies in xenotransplantation. PJ Cowan (St Vincents Hospital Melbourne), AJF d’Apice (St Vincents Hospital Melbourne), MB Nottle. NHMRC Project Grant. 558408 1.172 million
2008-2012 Which transgenic pig will be used for islet transplantation into humans? PJ  O’Connell  (Westmead Millennium Institute), AJF d’Apice (St Vincents Hospital) , PJ Cowan (St Vincents Hospital),  AM Lew (WEHI), MB Nottle, SJ Robson  (Harvard Medical School, Boston, USA). NHMRC/JDRF special program grant in Type 1 Diabetes 447718 3 million
Teaching
Undergraduate teaching
2016 - present Lectured on various aspects of reproductive physiology in Comparative Reproductive Biology III, Bachelor of Health Sciences,  Faculty of Health Sciences.
2012-2015 Conducted student-led  tutorials   in stem cells as part of the Masters Biotechnology (Biomedical Sciences) course in the School of Molecular Biosciences in the Faculty of Sciences.
2003 - present Lectured on various aspects of animal  biotechnology in  Animal Biotechnology III School of Animal and Veterinary Sciences, Faculty of Sciences.
1992 - present Lectured on reproductive physiology and ran student led tutorials on stem cells in Human Reproductive Health III, Bachelor of Health Sciences, Faculty of Health Sciences.
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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 Co-Supervisor Respiratory nurse management in people with chronic obstructive pulmonary disease Doctor of Philosophy Doctorate Part Time Mrs Karen Stacey Royals
    2019 Co-Supervisor Management of Bronchiectasis: A Tertiary Health Care Perspective Master of Philosophy (Clinical Science) Master Part Time Mrs Kathryn Anne Lawton
    2018 Principal Supervisor The Effect of GM-GSF on In Vitro Oocyte Maturation (IVM) Doctor of Philosophy Doctorate Full Time Mr Anmol Saini
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2019 - 2019 Principal Supervisor Best-Practice Evidence Based Medicine for the Effective Management of Chronic Obstructive Pulmonary Disease (COPD) Doctor of Philosophy Doctorate Full Time Miss Zoe Antonia Kopsaftis
    2017 - 2019 Principal Supervisor Insight into Appetite and Blood Glucose Regulation in Anorexia Nervosa and Health: Examining Gastrointestinal Changes in Starvation and with Short-term Refeeding Doctor of Philosophy Doctorate Part Time Ms Gabriella Alexandra Heruc
    2010 - 2013 Co-Supervisor Culturing Embryos from the Cleavage to Blastocyst Stage; an Opportunity to Improve Pluripotency and Embryonic Stem Cell Generation Efficiency Doctor of Philosophy Doctorate Full Time Dr Jared Campbell
    2009 - 2012 Principal Supervisor The Functional Role and Requirement for Long-Chain Omega-3 Polyunsaturated Fatty Acids in Breeding Gilts and Sows Doctor of Philosophy Doctorate Part Time Mr Robert John Christian Smits
    2004 - 2007 Principal Supervisor Factors Affecting the Developmental Competence of Pig Oocytes Matured In Vitro Doctor of Philosophy Doctorate Full Time Dr Melanie Bagg
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  • Committee Memberships

    Date Role Committee Institution Country
    2015 - ongoing Member Adelaide Medical School Executive University of Adelaide
    2015 - ongoing Member Adelaide Medical School Research Committee University of Adelaide
    2015 - ongoing Member Medical School Research Education Committee University of Adelaide
    2012 - 2016 Representative Research Education Development Committee University of Adelaide
    2012 - 2016 Representative International Scholarships Committee University of Adelaide
    2012 - 2016 Representative Domestic Scholarships Committee University of Adelaide
    2012 - 2016 Member Faculty Health Sciences Research Executive
    2012 - 2016 Member Faculty Health Sciences Research Executive
    2012 - 2016 Member Faculty of Health Sciences Research Committee
    2012 - 2014 Representative Student Matters Subcommittee University of Adelaide
    2010 - 2012 Member ARI Commercial Opportunity Panel
    2010 - ongoing Representative Research and Development Committee
    2010 - 2015 Member Research Committee School of Paediatrics and Reproductive Health
    2010 - 2013 Member Honours Committee, School of Paediatrics and Reproductive Health
    2009 - ongoing Member JDRF The Australian Type 1 Diabetes Research Directions Workshop
    2008 - ongoing Member NHMRC Workshop on the Risks and Benefits of xenotransplantation in Australia.
    2008 - ongoing Member International Society of Stem Cell Research
    2008 - 2011 Member Robinson Institute Management Committee
    2004 - 2011 Member Postgraduate Committee, School of Paediatrics and Reproductive Health
    1997 - ongoing Member Asian Reproductive Biotechnology Society
    1992 - ongoing Member International Embryo Transfer Society
    1992 - ongoing Member Australasian Pig Science Association
    1985 - ongoing Member Australian Society for Reproductive Biology
  • Consulting/Advisories

    Date Institution Department Organisation Type Country
    2003 - ongoing Australian Research Council and the National Health & Medical Research Council
    1990 - ongoing Various
  • Editorial Boards

    Date Role Editorial Board Name Institution Country
    2000 - ongoing Member Editorial Board, Reproduction and Development Japan
  • Position: Principal Research Fellow
  • Phone: 83134087
  • Email: mark.nottle@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 5
  • Room: WS5069.02
  • Org Unit: Paediatrics and Reproductive Health

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