Mark Gibson

Dr Mark Gibson

Senior Lecturer

Adelaide Medical School

Faculty of Health and Medical Sciences


Dr Mark Gibson - BSc (Hons), PhD, B. Pharm(Hons).

Dr Gibson is an experienced researcher with a long track record in the field of the cell and molecular biology of extracellular matrix. In particular he is studying the biology of elastic fibres, structures responsible for tissue elasticity. In the early part of his career Dr Gibson was responsible for identifying, cloning and sequencing of several of the molecular components of these structures. He has since focussed on the molecular assembly of these complex structures and on the role they play in growth factor regulation. This process becomes aberrant in incurable fibrotic diseases involving major organs such as heart, lung, kidney and liver and genetic diseases such as Marfan syndrome. Currently Dr Gibson's lab is investigating the role of elastic fibre-associated Latent TGF-beta Binding Proteins (LTBPs) in cellular and animal models of fibrosis and fibrotic diseases.

Dr Mark Gibson has been based since 1980 in Pathology at the University of Adelaide, where he has developed a long and distinguished track record on the cell and molecular biology of extracellular matrix, particularly on the difficult area of elastic fibre research.

Major Scientific Achievements

  • First identification and characterization of the undegraded form of type VI collagen.
  • First identification and characterization of MAGPs-1 and-2 and MP78/70 (ßig-h3).
  • First purification of fibrillin-1 from tissue
  • First molecular cloning of MAGP-1 and MAGP-2.
  • First identification and cloning of fibrillin-like protein (later known as LTBP-2).
  • Identification of MAGPs -1 and -2 as regular periodic components of fibrillin-microfibrils.
  • Identification of an elastin / collagen VI binding region on MAGP-1.
  • Establishment of MP78/70 (ßig-h3) as a widespread matrix protein.
  • Determination of distinct microfibrillar expression patterns for MAGP-1 and MAGP-2.
  • Characterisation of the human MAGP-2 gene.
  • Elucidation of MAGP-2 / cell interactions.
  • First characterization of biglycan and decorin interactions with elastic fibre components.
  • Establishment of ßig-h3 as a covalent component of collagen VI microfibrils.
  • Defining the molecular complexing of ßig-h3 with biglycan and decorin.
  • Mapping of MAGP-1 and MAGP-2 binding sites on fibrillins and microfibrils.
  • Mapping of LTBP-2 binding sites on fibrillins and microfibrils and establishing its competition for binding with latent TGF-beta complexes.
  • Defining LTBP-2 interactions with heparin and heparan sulphates, perlecan and syndecan-4.
  • Establishing that LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparan sulphates indicating a negative modulatory role in elastic fibre assembly
  • First identification of high-affinity interaction of FGF-2 with LTBP-2, defining the binding site and showing inhibition of FGF-2 activity
  • Discovery that LTBP-2 elevates TGF-beta expression in several cell types and identification of the domain responsible for this activity.
  • Identification of signalling pathways involved in LTBP-2 elevation of TGF-beta expression
  • Discovery that LTBP-2 is elevated in skin fibrosis and co-localises with FGF-2 in fibrotic lesions

National Competitive Schemes

Date Project/No. Investigators Funding Body Amount
2005-2010 Senior fellowship 349441 M.A.Gibson NHMRC $108,000 p.a.
2000-2004 Senior Fellowship 000095 M.A.Gibson NHMRC

$107,00 p.a.

2001-2004

Fellowship Project grant 158068

Mechanisms defining microfibril and elastic fibre assembly, structure and function.

M.A.Gibson NHMRC $95,000 p.a.
1996-2000

 Fellowship project grant No. 960495

The role of microfibrillar proteins in elastic fibre formation.

M.A.Gibson

E.G.Cleary

NHMRC $165,190 p.a.
1993-1996

fellowship project grant No. 931106

The function of microfibrillar proteins in elastic fibre formation.

M.A.Gibson NHMRC $111,250 p.a.
2008-2010

Project Grant No 519211

Proteins important for regulating activity and effects of growth factor TGF-beta in tissue development and diseases

M.A.Gibson

E Hanssen

R.P.Mecham

NHMRC $230,000 p.a.
2002-2004

Project grant No. 207700

:Elastic fibre-matrix interactions important for tissue development, morphology and function

M.A.Gibson NHMRC $126,000 p.a.
1999-2001

Project grant No 990622

Molecular interactions anchoring elastic fibres to collagen and matrix proteins

M.A.Gibson NHMRC $60,000 p.a.
1995-1997

Project grant No 950115

Molecular interactions of matrix macromolecules with elastic fibre components.

M.A.Gibson

E.G.Cleary

NHMRC 50,000 p.a.
1990-1991

Project grant No. 900220 

Microfibrillar defects in Marfan Syndrome.

E.G.Cleary

M.A.Gibson

J.C.Fanning

NHMRC 66,000 p.a.
1988-1992

Project grant No. 880751

Studies on microfibrillar systems of elastic and non-elastic tissues.

E.G.Cleary

M.A.Gibson

 

NHMRC $67,000 p.a.
2001

ARC International Research Exchange (IREX) Fellowship

M.A.Gibson

E.Hanssen

ARC $59,000 
         
         

National Competitive Infrastructure and Equipment Funding Schemes

Date Project/No. Investigators Funding Body Amount
2004

 Equipment Grant ID264518

Amersham Biosciences Typhoon #9410 Imaging system

Rodgers RJ, Ivell RJ, Gibson MA, Robertson SA,

Saint DA, Russell DL

NHMRC $111,500
2004 Amersham Biosciences Typhoon #9410 Imaging system

Rodgers RJ, Ivell RJ, Gibson MA, Robertson SA,

Saint DA, Russell DL

Faculty of Health Sciences $58,750
2005

equipment ID361655

CCD camera

Rodgers RJ, Ivell RJ, Gibson M, Russell DL, Saint D NHMRC $40,500
         

Teaching:

Teaching Activities 

Courses Developed

Date Course Title Institution Course Level/ Code URL
2011 Fundamentals of Human Nutrition U of A HLTH SC 2100 ID 106038 https://www.adelaide.edu.au/course-outlines/106038/1/sem-1/
2015 Ethics Science and Society U of A ANAT SC3500   

Courses Taught

Date Course Title Institution Course Level/ Code URL
2011-Date Fundamentals of Human Nutrition U of A HLTH SC 2100 ID 106038 https://www.adelaide.edu.au/course-outlines/106038/1/sem-1/
2012-Date Lifespan Nutrition U of A HLTH SC 3200   
2015-Date Exercise Nutrition and Metabolism U of A HLTH SC 3100  
2000-Date Pathology of Organ Systems/Essentials of Pathology U of A PATHOL 3003  
2001-Date Biology of Disease U of A PATHOL 2200  
2009-Date Biology of Human Disease I U of A NURSING 2005  
2009-Date Biology of Human Disease II U of A NURSING 2008  
2014-Date  DRUGS and Society U of A PHARM 2200  
2005-Date Structural Cell Biology/ Investigative Cell Biology U of A ANAT SC 3104  
2011-2014 Human Biology 1B U of A  ANAT SC 1103  
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  • Current Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2016 Principal Supervisor The function of LTBP-2 in Fibrosis and Fibrotic diseases Doctor of Philosophy Doctorate Full Time Mr Yike You
  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2012 - 2016 Principal Supervisor Function of Latent Transforming Growth Factor-B Binding Protein-2 (LTBP-2) in Elastinogenesis and Modulation of Growth Factor Storage, Expression and Activity in Normal and Fibrotic Tissues Doctor of Philosophy Doctorate Full Time Mr Mohamed Arshad Mohamed Sideek
    2005 - 2010 Principal Supervisor Characterisation of Novel Matrix-Binding Interaction for Latent Transforming Growth Factor-Beta-Binding Protein-2, with Emphasis on Heparin and Heparan Sulphate Proteoglycans Doctor of Philosophy Doctorate Full Time Dr Mahroo Kamkar Parsi
    2003 - 2006 Principal Supervisor Molecular Interactions of Latent Transforming Growth Factor-b Binding Protein-2 (LTBP-2) with Fibrillins and Other Extracellular Matrix Macromolecules: LTBP-2 Competes with LTBP-1 for Binding to Fibrillin-1 Suggesting that LTBP-2 may Modulate Latent TGF-b Storage Doctor of Philosophy Doctorate Full Time Ms Rena Hirani
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  • Committee Memberships

    Date Role Committee Institution Country
    2015 - 2015 Member School of Medical Sciences HSW Committee University of Adelaide Australia
    2011 - 2011 Member School of Medical Sciences Learning and Teaching Committee Medical Sciences, University of Adelaide Australia
    2008 - 2010 Member Faculty of Health Sciences Small Grants Evaluation Panel Faculty of Health Sciences, University of Adelaide Australia
    2008 - 2010 Member NHMRC Career Development Award panel NHMRC Australia
    2005 - 2010 Member School of Medical Sciences Research Committee Medical Sciences, University of Adelaide Australia
  • Offices Held

    Date Office Name Institution Country
    2015 - ongoing Workshop Co-ordinator, Ethics, Science and Society Medicine, University of Adelaide Australia
    2011 - ongoing Course Co-ordinator Fundamentals in Human Nutrition Medicine, University of Adelaide Australia
    2005 - 2010 Deputy Treasurer MBSANZ Matrix Biology Society of Australia and New Zealand Australia
    2000 - 2005 State Representative, Executive Committee MBSANZ Matrix Biology Society of Australia and New Zealand Australia
  • Position: Senior Lecturer
  • Phone: 83135337
  • Email: mark.gibson@adelaide.edu.au
  • Campus: North Terrace
  • Building: Helen Mayo North, floor 3
  • Room: 3 30a
  • Org Unit: Medical Sciences

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