Dr Mark Gibson
Visiting Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Mark Gibson - BSc (Hons), PhD, B. Pharm(Hons).
Dr Gibson is an experienced researcher with a long track record in the field of the cell and molecular biology of extracellular matrix. In particular he is studying the biology of elastic fibres, structures responsible for tissue elasticity. In the early part of his career Dr Gibson was responsible for identifying, cloning and sequencing of several of the molecular components of these structures. He has since focussed on the molecular assembly of these complex structures and on the role they play in growth factor regulation. This process becomes aberrant in incurable fibrotic diseases involving major organs such as heart, lung, kidney and liver and genetic diseases such as Marfan syndrome. Currently Dr Gibson's lab is investigating the role of elastic fibre-associated Latent TGF-beta Binding Proteins (LTBPs) in cellular and animal models of fibrosis and fibrotic diseases.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
Dr Mark Gibson has been based since 1980 in Pathology at the University of Adelaide, where he has developed a long and distinguished track record on the cell and molecular biology of extracellular matrix, particularly on the difficult area of elastic fibre research.
Major Scientific Achievements
- First identification and characterization of the undegraded form of type VI collagen.
- First identification and characterization of MAGPs-1 and-2 and MP78/70 (ßig-h3).
- First purification of fibrillin-1 from tissue
- First molecular cloning of MAGP-1 and MAGP-2.
- First identification and cloning of fibrillin-like protein (later known as LTBP-2).
- Identification of MAGPs -1 and -2 as regular periodic components of fibrillin-microfibrils.
- Identification of an elastin / collagen VI binding region on MAGP-1.
- Establishment of MP78/70 (ßig-h3) as a widespread matrix protein.
- Determination of distinct microfibrillar expression patterns for MAGP-1 and MAGP-2.
- Characterisation of the human MAGP-2 gene.
- Elucidation of MAGP-2 / cell interactions.
- First characterization of biglycan and decorin interactions with elastic fibre components.
- Establishment of ßig-h3 as a covalent component of collagen VI microfibrils.
- Defining the molecular complexing of ßig-h3 with biglycan and decorin.
- Mapping of MAGP-1 and MAGP-2 binding sites on fibrillins and microfibrils.
- Mapping of LTBP-2 binding sites on fibrillins and microfibrils and establishing its competition for binding with latent TGF-beta complexes.
- Defining LTBP-2 interactions with heparin and heparan sulphates, perlecan and syndecan-4.
- Establishing that LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparan sulphates indicating a negative modulatory role in elastic fibre assembly
- First identification of high-affinity interaction of FGF-2 with LTBP-2, defining the binding site and showing inhibition of FGF-2 activity
- Discovery that LTBP-2 elevates TGF-beta expression in several cell types and identification of the domain responsible for this activity.
- Identification of signalling pathways involved in LTBP-2 elevation of TGF-beta expression
- Discovery that LTBP-2 is elevated in skin fibrosis and co-localises with FGF-2 in fibrotic lesions
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Appointments
Date Position Institution name 2011 Senior lecturer University of Adelaide 1993 - 2010 NHMRC Senior Research Fellow 1993-2010 University of Adelaide 1990 - 1991 NIH Fogarty International Research Fellow Washington University in St. Louis 1984 - 1984 Michel Foundation Research Fellow University of Adelaide 1982 - 1992 NHMRC Senior Research Officer University of Adelaide 1980 - 1981 Research Associate University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2008 Research Award NHMRC Project Grant Proteins important for regulating activity and effects of growth factor TGF-beta in tissue development and diseases NHMRC Australia $230,000 p.a. 2005 Research Award NHMRC Senior Fellowship NHMRC Australia 108,000 p.a. 1990 Fellowship NIH Fogarty International Fellowship NIH United States US$20,000 p.a. -
Education
Date Institution name Country Title 1997 - 2001 University of South Australia Australia B. Pharm(Hons) 1976 - 1980 University of Manchester United Kingdom PhD 1973 - 1976 University of Manchester United Kingdom BSc (Hons) -
Research Interests
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Journals
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Book Chapters
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Conference Papers
Year Citation 2009 Hayes, A., Smith, S., Gibson, M., & Melrose, J. (2009). Association of perlecan with microfibrillar extracellular matrix proteins (fibrillin-1, LTBP-2, MAGP-1) suggests a novel role in elastic microfibril assembly and the functional status of tensional and weight-bearing connective tissues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 90 (pp. A121-A122). York Univ, York, ENGLAND: WILEY-BLACKWELL PUBLISHING, INC. 2008 Rodgers, R., Prodoehl, M., Irving-Rodgers, H., Sullivan, T., Micke, G., Bonner, W., . . . Perry, V. (2008). Effect of diet in pregnancy on the expression of genes involved in TGF-beta superfamily bioavailability in the bovine ovarian cortex of female offspring. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 111). Kona, HI: SOC STUDY REPRODUCTION.
2005 Gibson, M., Hirani, R., & Hanssen, E. (2005). LTBP-2 competes with LTBP-1 for binding to fibrillin-1 and interacts with basement membrane collagen-IV. In Annual Meeting of the Matrix Biology Society of Australia and New Zealand. Victor Harbor, S. Aust.: Matrix Biology Society of Australia and New Zealand. 2005 Gibson, M., & Hanssen, E. (2005). Molecular analysis of homotypic aggregates of βig-h3 found in tissues. In Annual Meeting of the Matrix Biology Society of Australia and New Zealand. Victor Harbor, S. Aust.: Matrix Biology Society of Australia and New Zealand. 2005 Gibson, M., Kamkar Parsi, M., & Hanssen, E. (2005). A proteomic approach to identifying matrix proteins interacting with transforming growth factor-β-inducible gene h-3 (βig-h3). In 29th Annual meeting of the Matrix Biology Society of Australia and New Zealand: A Close Encounter of the Matrix Kind (pp. 33). Victor Harbor, South Australia: Matrix Biology Society of Australia and New Zealand. 2005 Gibson, M., Hanssen, E., & Reinboth, B. (2005). Recombinant expression of βig-h3 domains for identification of binding sites for collagen type VI and SLRPs. In 29th Annual meeting of the Matrix Biology Society of Australia and New Zealand: A Close Encounter of the Matrix Kind (pp. 32). Victor Harbor, South Australia: Matrix Biology Society of Australia and New Zealand. 1990 Cleary, E. G., Gibson, M. A., Kumaratilake, J. S., & Fanning, J. C. (1990). Microfibrillar components of elastic fibers. In A. M. Tamburro, & J. M. Davidson (Eds.), Proceedings of the International Congress on Elastin, Chemical and biological aspects (pp. 191-203). Italy: Galantina, Congedo Editore. 1986 Fanning, J. C., Hughes, J. L., Gibson, M. A., Kumaratilake, J. S., Krishnan, R., & Cleary, E. G. (1986). Double labeling of the components of the elastic fiber using protein-A-dextran -gold probes.. In Proceedings of XI International Congress on Electron Microscopy (pp. 2705-2706). Japan: Koyoto.
National Competitive Schemes
| Date | Project/No. | Investigators | Funding Body | Amount |
|---|---|---|---|---|
| 2005-2010 | Senior fellowship 349441 | M.A.Gibson | NHMRC | $108,000 p.a. |
| 2000-2004 | Senior Fellowship 000095 | M.A.Gibson | NHMRC |
$107,00 p.a. |
| 2001-2004 |
Fellowship Project grant 158068 Mechanisms defining microfibril and elastic fibre assembly, structure and function. |
M.A.Gibson | NHMRC | $95,000 p.a. |
| 1996-2000 |
Fellowship project grant No. 960495 The role of microfibrillar proteins in elastic fibre formation. |
M.A.Gibson E.G.Cleary |
NHMRC | $165,190 p.a. |
| 1993-1996 |
fellowship project grant No. 931106 The function of microfibrillar proteins in elastic fibre formation. |
M.A.Gibson | NHMRC | $111,250 p.a. |
| 2008-2010 |
Project Grant No 519211 Proteins important for regulating activity and effects of growth factor TGF-beta in tissue development and diseases |
M.A.Gibson E Hanssen R.P.Mecham |
NHMRC | $230,000 p.a. |
| 2002-2004 |
Project grant No. 207700 :Elastic fibre-matrix interactions important for tissue development, morphology and function |
M.A.Gibson | NHMRC | $126,000 p.a. |
| 1999-2001 |
Project grant No 990622 Molecular interactions anchoring elastic fibres to collagen and matrix proteins |
M.A.Gibson | NHMRC | $60,000 p.a. |
| 1995-1997 |
Project grant No 950115 Molecular interactions of matrix macromolecules with elastic fibre components. |
M.A.Gibson E.G.Cleary |
NHMRC | 50,000 p.a. |
| 1990-1991 |
Project grant No. 900220 Microfibrillar defects in Marfan Syndrome. |
E.G.Cleary M.A.Gibson J.C.Fanning |
NHMRC | 66,000 p.a. |
| 1988-1992 |
Project grant No. 880751 Studies on microfibrillar systems of elastic and non-elastic tissues. |
E.G.Cleary M.A.Gibson
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NHMRC | $67,000 p.a. |
| 2001 |
ARC International Research Exchange (IREX) Fellowship |
M.A.Gibson E.Hanssen |
ARC | $59,000 |
National Competitive Infrastructure and Equipment Funding Schemes
| Date | Project/No. | Investigators | Funding Body | Amount |
|---|---|---|---|---|
| 2004 |
Equipment Grant ID264518 Amersham Biosciences Typhoon #9410 Imaging system |
Rodgers RJ, Ivell RJ, Gibson MA, Robertson SA, Saint DA, Russell DL |
NHMRC | $111,500 |
| 2004 | Amersham Biosciences Typhoon #9410 Imaging system |
Rodgers RJ, Ivell RJ, Gibson MA, Robertson SA, Saint DA, Russell DL |
Faculty of Health Sciences | $58,750 |
| 2005 |
equipment ID361655 CCD camera |
Rodgers RJ, Ivell RJ, Gibson M, Russell DL, Saint D | NHMRC | $40,500 |
Teaching:
Teaching Activities
Courses Developed
| Date | Course Title | Institution | Course Level/ Code | URL |
|---|---|---|---|---|
| 2011 | Fundamentals of Human Nutrition | U of A | HLTH SC 2100 ID 106038 | https://www.adelaide.edu.au/course-outlines/106038/1/sem-1/ |
| 2015 | Ethics Science and Society | U of A | ANAT SC3500 |
Courses Taught
| Date | Course Title | Institution | Course Level/ Code | URL |
|---|---|---|---|---|
| 2011-Date | Fundamentals of Human Nutrition | U of A | HLTH SC 2100 ID 106038 | https://www.adelaide.edu.au/course-outlines/106038/1/sem-1/ |
| 2012-Date | Lifespan Nutrition | U of A | HLTH SC 3200 | |
| 2015-Date | Exercise Nutrition and Metabolism | U of A | HLTH SC 3100 | |
| 2000-Date | Pathology of Organ Systems/Essentials of Pathology | U of A | PATHOL 3003 | |
| 2001-Date | Biology of Disease | U of A | PATHOL 2200 | |
| 2009-Date | Biology of Human Disease I | U of A | NURSING 2005 | |
| 2009-Date | Biology of Human Disease II | U of A | NURSING 2008 | |
| 2014-Date | DRUGS and Society | U of A | PHARM 2200 | |
| 2005-Date | Structural Cell Biology/ Investigative Cell Biology | U of A | ANAT SC 3104 | |
| 2011-2014 | Human Biology 1B | U of A | ANAT SC 1103 |
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Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2012 - 2016 Principal Supervisor Function of Latent Transforming Growth Factor-B Binding Protein-2 (LTBP-2) in Elastinogenesis and Modulation of Growth Factor Storage, Expression and Activity in Normal and Fibrotic Tissues Doctor of Philosophy Doctorate Full Time Mr Mohamed Arshad Mohamed Sideek 2005 - 2010 Principal Supervisor Characterisation of Novel Matrix-Binding Interaction for Latent Transforming Growth Factor-Beta-Binding Protein-2, with Emphasis on Heparin and Heparan Sulphate Proteoglycans Doctor of Philosophy Doctorate Full Time Dr Mahroo Kamkar Parsi 2003 - 2006 Principal Supervisor Molecular Interactions of Latent Transforming Growth Factor-b Binding Protein-2 (LTBP-2) with Fibrillins and Other Extracellular Matrix Macromolecules: LTBP-2 Competes with LTBP-1 for Binding to Fibrillin-1 Suggesting that LTBP-2 may Modulate Latent TGF-b Storage Doctor of Philosophy Doctorate Full Time Ms Rena Hirani
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Committee Memberships
Date Role Committee Institution Country 2015 - 2015 Member School of Medical Sciences HSW Committee University of Adelaide Australia 2011 - 2011 Member School of Medical Sciences Learning and Teaching Committee Medical Sciences, University of Adelaide Australia 2008 - 2010 Member Faculty of Health Sciences Small Grants Evaluation Panel Faculty of Health Sciences, University of Adelaide Australia 2008 - 2010 Member NHMRC Career Development Award panel NHMRC Australia 2005 - 2010 Member School of Medical Sciences Research Committee Medical Sciences, University of Adelaide Australia -
Offices Held
Date Office Name Institution Country 2015 - ongoing Workshop Co-ordinator, Ethics, Science and Society Medicine, University of Adelaide Australia 2011 - ongoing Course Co-ordinator Fundamentals in Human Nutrition Medicine, University of Adelaide Australia 2005 - 2010 Deputy Treasurer MBSANZ Matrix Biology Society of Australia and New Zealand Australia 2000 - 2005 State Representative, Executive Committee MBSANZ Matrix Biology Society of Australia and New Zealand Australia
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