Dr Mark Gibson

Visiting Research Fellow

School of Biomedicine

Faculty of Health and Medical Sciences

Dr Mark Gibson - BSc (Hons), PhD, B. Pharm(Hons).

Dr Gibson is an experienced researcher with a long track record in the field of the cell and molecular biology of extracellular matrix. In particular he is studying the biology of elastic fibres, structures responsible for tissue elasticity. In the early part of his career Dr Gibson was responsible for identifying, cloning and sequencing of several of the molecular components of these structures. He has since focussed on the molecular assembly of these complex structures and on the role they play in growth factor regulation. This process becomes aberrant in incurable fibrotic diseases involving major organs such as heart, lung, kidney and liver and genetic diseases such as Marfan syndrome. Currently Dr Gibson's lab is investigating the role of elastic fibre-associated Latent TGF-beta Binding Proteins (LTBPs) in cellular and animal models of fibrosis and fibrotic diseases.

My Research
Career
Publications
Grants and Funding
Teaching
Supervision
Professional Activities
Contact

Dr Mark Gibson has been based since 1980 in Pathology at the University of Adelaide, where he has developed a long and distinguished track record on the cell and molecular biology of extracellular matrix, particularly on the difficult area of elastic fibre research.

Major Scientific Achievements

First identification and characterization of the undegraded form of type VI collagen.
First identification and characterization of MAGPs-1 and-2 and MP78/70 (ßig-h3).
First purification of fibrillin-1 from tissue
First molecular cloning of MAGP-1 and MAGP-2.
First identification and cloning of fibrillin-like protein (later known as LTBP-2).
Identification of MAGPs -1 and -2 as regular periodic components of fibrillin-microfibrils.
Identification of an elastin / collagen VI binding region on MAGP-1.
Establishment of MP78/70 (ßig-h3) as a widespread matrix protein.
Determination of distinct microfibrillar expression patterns for MAGP-1 and MAGP-2.
Characterisation of the human MAGP-2 gene.
Elucidation of MAGP-2 / cell interactions.
First characterization of biglycan and decorin interactions with elastic fibre components.
Establishment of ßig-h3 as a covalent component of collagen VI microfibrils.
Defining the molecular complexing of ßig-h3 with biglycan and decorin.
Mapping of MAGP-1 and MAGP-2 binding sites on fibrillins and microfibrils.
Mapping of LTBP-2 binding sites on fibrillins and microfibrils and establishing its competition for binding with latent TGF-beta complexes.
Defining LTBP-2 interactions with heparin and heparan sulphates, perlecan and syndecan-4.
Establishing that LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparan sulphates indicating a negative modulatory role in elastic fibre assembly
First identification of high-affinity interaction of FGF-2 with LTBP-2, defining the binding site and showing inhibition of FGF-2 activity
Discovery that LTBP-2 elevates TGF-beta expression in several cell types and identification of the domain responsible for this activity.
Identification of signalling pathways involved in LTBP-2 elevation of TGF-beta expression
Discovery that LTBP-2 is elevated in skin fibrosis and co-localises with FGF-2 in fibrotic lesions

Appointments

Date	Position	Institution name
2011 - ongoing	Senior lecturer	University of Adelaide
1993 - 2010	NHMRC Senior Research Fellow 1993-2010	University of Adelaide
1990 - 1991	NIH Fogarty International Research Fellow	Washington University in St. Louis
1984 - 1984	Michel Foundation Research Fellow	University of Adelaide
1982 - 1992	NHMRC Senior Research Officer	University of Adelaide
1980 - 1981	Research Associate	University of Adelaide

Awards and Achievements

Date	Type	Title	Institution Name	Country	Amount
2008	Research Award	NHMRC Project Grant Proteins important for regulating activity and effects of growth factor TGF-beta in tissue development and diseases	NHMRC	Australia	$230,000 p.a.
2005	Research Award	NHMRC Senior Fellowship	NHMRC	Australia	108,000 p.a.
1990	Fellowship	NIH Fogarty International Fellowship	NIH	United States	US$20,000 p.a.

Education

Date	Institution name	Country	Title
1997 - 2001	University of South Australia	Australia	B. Pharm(Hons)
1976 - 1980	University of Manchester	United Kingdom	PhD
1973 - 1976	University of Manchester	United Kingdom	BSc (Hons)

Research Interests

Biochemistry & Molecular Biology Cell Development, Proliferation and Death Cellular Interactions Proteins and Peptides Receptors and Membrane Biology Signal Transduction Cardiac, Respiratory and Vascular Health Musculoskeletal Health

Journals

Year	Citation
2021	Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R. P., Kumra, H., . . . Bassnett, S. (2021). Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biology, 95, 15-31. DOI Scopus8 Europe PMC5
2017	Sideek, M., Smith, J., Menz, C., Adams, J., Cowin, A., & Gibson, M. (2017). A central bioactive region of LTBP-2 stimulates the expression of TGF-β1 in fibroblasts via Akt and p38 signalling pathways. International Journal of Molecular Sciences, 18(10), 1-17. DOI Scopus8 WoS6 Europe PMC5
2016	Sideek, M. A., Teia, A., Kopecki, Z., Cowin, A. J., & Gibson, M. A. (2016). Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar. Jornal of Molecular Histology, 47(1), 35-45. DOI Scopus18 WoS19 Europe PMC14
2015	Mecham, R., & Gibson, M. (2015). The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche. Matrix Biology, 47, 13-33. DOI Scopus41 WoS42 Europe PMC32
2015	Menz, C., Parsi, M., Adams, J., Sideek, M., Kopecki, Z., Cowin, A., & Gibson, M. (2015). LTBP-2 has a single high-affinity binding site for FGF-2 and blocks FGF-2-induced cell proliferation. PLoS One, 10(8), e0135577-1-e0135577-18. DOI Scopus13 WoS14 Europe PMC9
2014	Sideek, M., Menz, C., Kamkar Parsi, M., & Gibson, M. (2014). LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis. Matrix Biology, 34, 114-123. DOI Scopus24 WoS21 Europe PMC18
2014	Hayes, A., Gibson, M., Shu, C., & Melrose, J. (2014). Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. Tissue and Cell, 46(3), 185-197. DOI Scopus12 WoS12 Europe PMC9
2011	Hayes, A., Smith, S., Gibson, M., & Melrose, J. (2011). Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc. Spine, 36(21), E1365-E1372. DOI Scopus31 WoS27 Europe PMC23
2011	Hatzirodos, N., Bayne, R., Irving-Rodgers, H., Hummitzsch, K., Sabatier, L., Lee, S., . . . Rodgers, R. (2011). Linkage of regulators of TGF-β activity in the fetal ovary to polycystic ovary syndrome. FASEB Journal, 25(7), 2256-2265. DOI Scopus66 WoS60 Europe PMC46
2010	Brinckmann, J., Hunzelmann, N., Kahle, B., Rohwedel, J., Kramer, J., Gibson, M., . . . Reinhardt, D. (2010). Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta. Laboratory Investigation, 90(5), 739-752. DOI Scopus47 WoS47 Europe PMC31
2010	Kamkar Parsi, M., Adams, J., Whitelock, J., & Gibson, M. (2010). LTBP-2 has multiple heparin/heparan sulfate binding sites. Matrix Biology, 29(5), 393-401. DOI Scopus28 WoS26 Europe PMC21
2009	Prodoehl, M., Hatzirodos, N., Irving-Rodgers, H., Zhao, Z., Painter, J., Hickey, T., . . . Rodgers, R. (2009). Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovaries. Molecular Human Reproduction, 15(12), 829-841. DOI Scopus37 WoS32 Europe PMC20
2009	Prodoehl, M., Irving-Rodgers, H., Bonner, W., Sullivan, T., Micke, G., Gibson, M., . . . Rodgers, R. (2009). Fibrillins and latent TGFβ binding proteins in bovine ovaries of offspring following high or low protein diets during pregnancy of dams. Molecular and Cellular Endocrinology, 307(1-2), 133-141. DOI Scopus16 WoS16 Europe PMC12
2007	Hirani, R., Hanssen, E., & Gibson, M. (2007). LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. Matrix Biology, 26(4), 213-223. DOI Scopus97 WoS96 Europe PMC70
2006	Reinboth, B., Thomas, J., Hanssen, E., & Gibson, M. (2006). beta ig-h3 interacts directly with biglycan and decorin, promotes collagen VI aggregation, and participates in ternary complexing with these macromolecules. Journal of Biological Chemistry, 281(12), 7816-7824. DOI Scopus68 WoS70 Europe PMC52
2004	Hanssen, E., Hew, F., Bradford, E., & Gibson, M. (2004). MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. Journal of Biological Chemistry, 279(28), 29185-29194. DOI Scopus39 WoS38 Europe PMC29
2003	Hanssen, E., Reinboth, B., & Gibson, M. (2003). Covalent and non-covalent interactions of b ig-h3 with collagen VI - big-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils. Journal of Biological Chemistry, 278(27), 24334-24341. DOI Scopus63 WoS60 Europe PMC44
2002	Harumiya, S., Gibson, M., & Koshihara, Y. (2002). Antisense suppression of collagen VI synthesis results in reduced expression of collagen I in normal human osteoblast-like cells. Bioscience Biotechnology and Biochemistry, 66(12), 2743-2747. DOI Scopus16 WoS14 Europe PMC12
2002	Reinboth, B., Hanssen, E., Cleary, E., & Gibson, M. (2002). Molecular interactions of biglycan and decorin with elastic fiber components - Biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein. Journal of Biological Chemistry, 277(6), 3950-3957. DOI Scopus137 WoS131 Europe PMC95
2001	Jensen, S., Reinhardt, D., Gibson, M., & Weiss, A. (2001). Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. Journal of Biological Chemistry, 276(43), 39661-39666. DOI Scopus113 WoS107 Europe PMC76
2000	Kitahama, S., Gibson, M., Hatzinikolas, G., Hay, S., Kuliwaba, J., Evdokiou, A., . . . Findlay, D. (2000). Expression of fibrillins and other microfibril-associated proteins in human bone and osteoblast-like cells. Bone, 27(1), 61-67. DOI Scopus52 WoS50 Europe PMC31
2000	Reinboth, B., Finnis, M., Gibson, M., Sandberg, L., & Cleary, E. (2000). Developmental expression of dermatan sulfate proteoglycans in the elastic bovine nuchal ligament. Matrix Biology, 19(2), 149-162. DOI Scopus19 WoS17 Europe PMC14
2000	Sterzel, R., Hartner, A., Schlotzer-Schrehardt, U., Voit, S., Hausknecht, B., Doliana, R., . . . Bressan, G. (2000). Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture. Kidney International, 58(4), 1588-1602. DOI Scopus47 WoS41 Europe PMC27
1999	Franzon, V., Gibson, M., Hatzinikolas, G., Woollatt, E., Sutherland, G., & Cleary, E. (1999). Molecular cloning of a novel human PAPS synthetase which is differentially expressed in metastatic and non-metastatic colon carcinoma cells. International Journal of Biochemistry and Cell Biology, 31(5), 613-626. DOI Scopus23 WoS21 Europe PMC17
1999	Gibson, M., Leavesley, D., & Ashman, L. (1999). Microfibril-associated glycoprotein-2 specifically interacts with a range of bovine and human cell types via αVβ3 integrin. Journal of Biological Chemistry, 274(19), 13060-13065. DOI Scopus61 WoS56 Europe PMC41
1998	Hatzinikolas, G., & Gibson, M. (1998). The Exon Structure of the Human MAGP-2 Gene. Journal of Biological Chemistry, 273, 29309-29314.
1998	Hatzinikolas, G., & Gibson, M. A. (1998). The exon structure of the human MAGP-2 gene: Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region. Journal of Biological Chemistry, 273(45), 29309-39314. DOI Scopus11 WoS11 Europe PMC6
1998	Gibson, M., Finnis, M., Kumaratilake, J., & Cleary, E. (1998). Microfibril-associated glycoprotein-2 (MAGP-2) is specifically associated with fibrillin-containing microfibrils but exhibits more restricted patterns of tissue localization and developmental expression than its structural relative MAGP-1. Journal of Histochemistry and Cytochemistry, 46(8), 871-885. DOI Scopus77 WoS74 Europe PMC46
1998	Gibson, M., Ellis, S., Ades, L., Haan, E., & Cleary, E. (1998). Preferential pre-mRNA utilisation of an upstream cryptic 5' splice site created by a single base deletion mutation in exon 37 of the FBN-1 gene. European Journal of Biochemistry, 256(1), 221-228. DOI Scopus4 WoS4 Europe PMC2
1997	Gibson, M., Kumaratilake, J., & Cleary, E. (1997). Immunohistochemical and ultrastructural localization of MP78/70 (βig-h3) in extracellular matrix of developing and mature bovine tissues. Journal of Histochemistry and Cytochemistry, 45(12), 1683-1696. DOI Scopus70 WoS69 Europe PMC43
1997	Finnis, M., & Gibson, M. (1997). Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the α3(VI) chain of type VI collagen. Journal of Biological Chemistry, 272(36), 22817-22823. DOI Scopus78 WoS78 Europe PMC52
1996	Bashir, M. M., Han, M. D., Abrams, W. R., Tucker, T., Ma, R. I., Gibson, M., . . . Rosenbloom, J. (1996). Analysis of the human gene encoding latent transforming growth factor-β-binding protein-2. International Journal of Biochemistry and Cell Biology, 28(5), 531-542. DOI Scopus20 WoS20 Europe PMC13
1996	Gibson, M., Hatzinikolas, G., Kumaratilake, J., Sandberg, L., Nicholl, J., Sutherland, G., & Cleary, E. (1996). Erratum: Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25) (The Journal of Biological Chemistry (1996) 271 (1096-1103)). Journal of Biological Chemistry, 271(9), 5288. Scopus1
1996	Gibson, M., Hatzinikolas, G., Kumaratilake, J., Sandberg, L., Nicholl, J., Sutherland, G., & Cleary, E. (1996). Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). Journal of Biological Chemistry, 271(2), 1096-1103. DOI Scopus134 WoS127 Europe PMC75
1996	Henderson, M., Polewski, R., Fanning, J., & Gibson, M. (1996). Microfibril-associated glycoprotein-1 (MAGP-1) is specifically located on the beads of the beaded-filament structure for fibrillin-containing microfibrils as visualized by the rotary shadowing technique. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 44(12), 1389-1397. DOI Scopus83 WoS73 Europe PMC49
1995	Gibson, M., Hatzinikolas, G., Davis, E., Baker, E., Sutherland, G., & Mecham, R. (1995). Bovine latent transforming growth factor β1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils. Molecular and Cell Biology, 15(12), 6932-6952. DOI Scopus163 WoS162 Europe PMC97
1995	Mariencheck, M. C., Davis, E. C., Zhang, H., Ramirez, F., Rosenbloom, J., Gibson, M. A., . . . Mecham, R. P. (1995). Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues. Connective Tissue Research, 31(2), 87-97. DOI Scopus75 WoS72 Europe PMC44
1994	Brown-Augsburger, P., Broekelmann, T., Mecham, L., Mercer, R., Gibson, M. A., Cleary, E. G., . . . Mecham, R. P. (1994). Microfibril-associated glycoprotein binds to the carboxyl-terminal domain of tropoelastin and is a substrate for transglutaminase. Journal of Biological Chemistry, 269(45), 28443-28449. DOI Scopus101 WoS102 Europe PMC66
1993	MECHAM, R. P., DAVIS, E. C., PARKS, W., GIBSON, M. A., & FILIAGGI, M. (1993). ASSEMBLY OF THE ELASTIC FIBER - A COMPLEX PROBLEM IN DEVELOPMENTAL REGULATION. JOURNAL OF CELLULAR BIOCHEMISTRY, 146. WoS1
1992	FILIAGGI, M., GIBSON, M., ROSENBLOOM, J., & MECHAM, R. (1992). DEVELOPMENTAL EXPRESSION OF MICROFIBRILLAR COMPONENTS IN FETAL BOVINE AORTA AND NUCHAL LIGAMENT. MOLECULAR BIOLOGY OF THE CELL, 3, A225.
1992	GIBSON, M., DAVIS, E., FILIAGGI, M., & MECHAM, R. (1992). ISOLATION AND PARTIAL CHARACTERIZATION OF A NEW FIBRILLIN-LIKE PROTEIN. MOLECULAR BIOLOGY OF THE CELL, 3, A224. WoS1
1991	Gibson, M. A., Sandberg, L. B., Grosso, L. E., & Cleary, E. G. (1991). Complementary DNA cloning establishes microfibril-associated glycoprotein (MAGP) to be a discrete component of the elastin-associated microfibrils. Journal of Biological Chemistry, 266(12), 7596-7601. DOI Scopus96 WoS114 Europe PMC56
1989	Kumaratilake, J. S., Gibson, M. A., Fanning, J. C., & Cleary, E. G. (1989). The tissue distribution of microfibrils reacting with a monospecific antibody to MAGP, the major glycoprotein antigen of elastin-associated microfibrils. European Journal of Cell Biology, 50(1), 117-127. Scopus54 WoS62 Europe PMC32
1989	Gibson, M. A., Kumaratilake, J. S., & Cleary, E. G. (1989). The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissues. Journal of Biological Chemistry, 264(8), 4590-4598. DOI Scopus150 WoS176 Europe PMC95
1988	White, J. F., Hughes, J. L., Kumaratilake, J. S., Fanning, J. C., Gibson, M. A., Krishnan, R., & Cleary, E. G. (1988). Post-embedding methods for immunolocalization of elastin and related components in tissues. Journal of Histochemistry and Cytochemistry, 36(12), 1543-1551. DOI Scopus13 WoS21 Europe PMC8
1987	GIBSON, M. A., & CLEARY, E. G. (1987). THE IMMUNOHISTOCHEMICAL LOCALIZATION OF MICROFIBRIL-ASSOCIATED GLYCOPROTEIN (MAGP) IN ELASTIC AND NONELASTIC TISSUES. IMMUNOLOGY AND CELL BIOLOGY, 65(4), 345-356. DOI WoS54 Europe PMC31
1987	Gibson, M., & Cleary, E. (1987). The immunohistochemical localisation of microfibril-associated glycoprotein (MAGP) in elastic and non-elastic tissues.. Immunology and cell biology, 65 ( Pt 4), 345-356. DOI Scopus51
1986	Gibson, M. A., & Cleary, E. G. (1986). Identification and isolation of the major glycoprotein antigen associated with elastic fibre microfibrils.. Agents and actions. Supplements, 18, 121-123. DOI
1986	Gibson, M. A., Hughes, J. L., Fanning, J. C., & Cleary, E. G. (1986). The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein. Journal of Biological Chemistry, 261(24), 11429-11436. DOI Scopus106 WoS119 Europe PMC70
1985	Gibson, M. A., & Cleary, E. G. (1985). CL glycoprotein is the tissue form of type VI collagen. Journal of Biological Chemistry, 260(20), 11149-11159. DOI Scopus29 Europe PMC23
1985	GIBSON, M. A., & CLEARY, E. G. (1985). CL GLYCOPROTEIN IS THE TISSUE FORM OF TYPE-VI COLLAGEN. JOURNAL OF BIOLOGICAL CHEMISTRY, 260(20), 1149-1159. WoS55
1984	Prosser, I. W., Gibson, M. A., & Cleary, E. G. (1984). Microfibrillar protein from elastic tissue: A critical evaluation. Australian Journal of Experimental Biology and Medical Science, 62(4), 485-505. DOI Scopus16 Europe PMC11
1984	PROSSER, I. W., GIBSON, M. A., & CLEARY, E. G. (1984). MICROFIBRILLAR PROTEIN FROM ELASTIC TISSUE - A CRITICAL-EVALUATION. AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 62(AUG), 485-505. DOI WoS24
1983	GIBSON, M. A., & CLEARY, E. G. (1983). FURTHER CHARACTERIZATION OF A COLLAGEN-LIKE GLYCOPROTEIN FROM ELASTIN-RICH TISSUES. CONNECTIVE TISSUE RESEARCH, 11(2-3), 228.
1983	Cleary, E. G., & Gibson, M. A. (1983). Elastin-associated microfibrils and microfibrillar proteins. International Review of Connective Tissue Research, VOL.10, 97-209. DOI Scopus202 WoS248 Europe PMC98
1983	Gibson, M., & Cleary, E. (1983). Distribution of CL Glycoprotein in Tissues: An Immunohistochemical Study. Topics in Catalysis, 3(6), 469-488. DOI Scopus24 WoS39 Europe PMC12
1982	Gibson, M., & Cleary, E. (1982). A collagen-like glycoprotein from elastin-rich tissues. Biochemical and Biophysical Research Communications, 105(4), 1288-1295. DOI Scopus32 WoS55 Europe PMC31
1982	Gibson, M. A., Grant, M. E., & Jackson, D. S. (1982). Two major non-collagenous glycoproteins in embryonic chick arteries. Connective Tissue Research, 10(2), 145-160. DOI Scopus4
1982	GIBSON, M., & CLEARY, E. (1982). COLLAGEN-LIKE GLYCOPROTEIN FROM ELASTIN-RICH TISSUES. CONNECTIVE TISSUE RESEARCH, 9(3), 207. WoS1
1981	GIBSON, M., GRANT, M., & JACKSON, D. (1981). ISOLATION AND PARTIAL CHARACTERIZATION OF MATRIX GLYCOPROTEINS FROM ELASTIC TISSUES OF CHICKS. CONNECTIVE TISSUE RESEARCH, 8(2), 137-138.

Book Chapters

Year	Citation
2004	Gibson, M. (2004). Microfibril-associated glycoprotein-1 (MAGP-1) and other non-fibrillin macromolecules which may possess a functional association with the 10 nm microfibrils. In P. Robinson, & M. Godfrey (Eds.), Marfan Syndrome: A primer for clinicians and scientists (pp. 161-172). 233 Spring St, New York, NY 10013: Kluwer Academic/Plenum Publishers.
1996	Cleary, E., & Gibson, M. (1996). Elastic tissue, elastin and elastin associated microfibrils. In Extracelluar Matrix Vol 2 Molecular Components and Interactions (pp. 95-141). Harwood Academic.
1995	Mecham, R., Broekelmann, T., Davis, E., Gibson, M., & Brown-Augsburger, P. (1995). Elastic fibre assembly: Macromolecular interactions. In The molecular pathology of elastic tissues (Vol. 192, pp. 172-184). J. Wiley. DOI Scopus33 WoS28 Europe PMC10

Conference Papers

Year	Citation
2009	Hayes, A., Smith, S., Gibson, M., & Melrose, J. (2009). Association of perlecan with microfibrillar extracellular matrix proteins (fibrillin-1, LTBP-2, MAGP-1) suggests a novel role in elastic microfibril assembly and the functional status of tensional and weight-bearing connective tissues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 90 (pp. A121-A122). York Univ, York, ENGLAND: WILEY-BLACKWELL PUBLISHING, INC.
2008	Rodgers, R., Prodoehl, M., Irving-Rodgers, H., Sullivan, T., Micke, G., Bonner, W., . . . Perry, V. (2008). Effect of diet in pregnancy on the expression of genes involved in TGF-beta superfamily bioavailability in the bovine ovarian cortex of female offspring. In BIOLOGY OF REPRODUCTION Vol. 78 (pp. 111). Kona, HI: SOC STUDY REPRODUCTION. DOI
2005	Gibson, M., Hirani, R., & Hanssen, E. (2005). LTBP-2 competes with LTBP-1 for binding to fibrillin-1 and interacts with basement membrane collagen-IV. In Annual Meeting of the Matrix Biology Society of Australia and New Zealand. Victor Harbor, S. Aust.: Matrix Biology Society of Australia and New Zealand.
2005	Gibson, M., & Hanssen, E. (2005). Molecular analysis of homotypic aggregates of βig-h3 found in tissues. In Annual Meeting of the Matrix Biology Society of Australia and New Zealand. Victor Harbor, S. Aust.: Matrix Biology Society of Australia and New Zealand.
2005	Gibson, M., Kamkar Parsi, M., & Hanssen, E. (2005). A proteomic approach to identifying matrix proteins interacting with transforming growth factor-β-inducible gene h-3 (βig-h3). In 29th Annual meeting of the Matrix Biology Society of Australia and New Zealand: A Close Encounter of the Matrix Kind (pp. 33). Victor Harbor, South Australia: Matrix Biology Society of Australia and New Zealand.
2005	Gibson, M., Hanssen, E., & Reinboth, B. (2005). Recombinant expression of βig-h3 domains for identification of binding sites for collagen type VI and SLRPs. In 29th Annual meeting of the Matrix Biology Society of Australia and New Zealand: A Close Encounter of the Matrix Kind (pp. 32). Victor Harbor, South Australia: Matrix Biology Society of Australia and New Zealand.
1990	Cleary, E. G., Gibson, M. A., Kumaratilake, J. S., & Fanning, J. C. (1990). Microfibrillar components of elastic fibers. In A. M. Tamburro, & J. M. Davidson (Eds.), Proceedings of the International Congress on Elastin, Chemical and biological aspects (pp. 191-203). Italy: Galantina, Congedo Editore.
1986	Fanning, J. C., Hughes, J. L., Gibson, M. A., Kumaratilake, J. S., Krishnan, R., & Cleary, E. G. (1986). Double labeling of the components of the elastic fiber using protein-A-dextran -gold probes.. In Proceedings of XI International Congress on Electron Microscopy (pp. 2705-2706). Japan: Koyoto.

National Competitive Schemes

Date	Project/No.	Investigators	Funding Body	Amount
2005-2010	Senior fellowship 349441	M.A.Gibson	NHMRC	$108,000 p.a.
2000-2004	Senior Fellowship 000095	M.A.Gibson	NHMRC	$107,00 p.a.
2001-2004	Fellowship Project grant 158068 Mechanisms defining microfibril and elastic fibre assembly, structure and function.	M.A.Gibson	NHMRC	$95,000 p.a.
1996-2000	Fellowship project grant No. 960495 The role of microfibrillar proteins in elastic fibre formation.	M.A.Gibson E.G.Cleary	NHMRC	$165,190 p.a.
1993-1996	fellowship project grant No. 931106 The function of microfibrillar proteins in elastic fibre formation.	M.A.Gibson	NHMRC	$111,250 p.a.
2008-2010	Project Grant No 519211 Proteins important for regulating activity and effects of growth factor TGF-beta in tissue development and diseases	M.A.Gibson E Hanssen R.P.Mecham	NHMRC	$230,000 p.a.
2002-2004	Project grant No. 207700 :Elastic fibre-matrix interactions important for tissue development, morphology and function	M.A.Gibson	NHMRC	$126,000 p.a.
1999-2001	Project grant No 990622 Molecular interactions anchoring elastic fibres to collagen and matrix proteins	M.A.Gibson	NHMRC	$60,000 p.a.
1995-1997	Project grant No 950115 Molecular interactions of matrix macromolecules with elastic fibre components.	M.A.Gibson E.G.Cleary	NHMRC	50,000 p.a.
1990-1991	Project grant No. 900220 Microfibrillar defects in Marfan Syndrome.	E.G.Cleary M.A.Gibson J.C.Fanning	NHMRC	66,000 p.a.
1988-1992	Project grant No. 880751 Studies on microfibrillar systems of elastic and non-elastic tissues.	E.G.Cleary M.A.Gibson	NHMRC	$67,000 p.a.
2001	ARC International Research Exchange (IREX) Fellowship	M.A.Gibson E.Hanssen	ARC	$59,000

National Competitive Infrastructure and Equipment Funding Schemes

Date	Project/No.	Investigators	Funding Body	Amount
2004	Equipment Grant ID264518 Amersham Biosciences Typhoon #9410 Imaging system	Rodgers RJ, Ivell RJ, Gibson MA, Robertson SA, Saint DA, Russell DL	NHMRC	$111,500
2004	Amersham Biosciences Typhoon #9410 Imaging system	Rodgers RJ, Ivell RJ, Gibson MA, Robertson SA, Saint DA, Russell DL	Faculty of Health Sciences	$58,750
2005	equipment ID361655 CCD camera	Rodgers RJ, Ivell RJ, Gibson M, Russell DL, Saint D	NHMRC	$40,500

Teaching:

Teaching Activities

Courses Developed

Date	Course Title	Institution	Course Level/ Code	URL
2011	Fundamentals of Human Nutrition	U of A	HLTH SC 2100 ID 106038	https://www.adelaide.edu.au/course-outlines/106038/1/sem-1/
2015	Ethics Science and Society	U of A	ANAT SC3500

Courses Taught

Date	Course Title	Institution	Course Level/ Code	URL
2011-Date	Fundamentals of Human Nutrition	U of A	HLTH SC 2100 ID 106038	https://www.adelaide.edu.au/course-outlines/106038/1/sem-1/
2012-Date	Lifespan Nutrition	U of A	HLTH SC 3200
2015-Date	Exercise Nutrition and Metabolism	U of A	HLTH SC 3100
2000-Date	Pathology of Organ Systems/Essentials of Pathology	U of A	PATHOL 3003
2001-Date	Biology of Disease	U of A	PATHOL 2200
2009-Date	Biology of Human Disease I	U of A	NURSING 2005
2009-Date	Biology of Human Disease II	U of A	NURSING 2008
2014-Date	DRUGS and Society	U of A	PHARM 2200
2005-Date	Structural Cell Biology/ Investigative Cell Biology	U of A	ANAT SC 3104
2011-2014	Human Biology 1B	U of A	ANAT SC 1103

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2016 - 2021	Principal Supervisor	Studies on the Functions of Latent Transforming Growth Factor Beta (TGF-Beta) Binding Protein-2 (LTBP-2) in the Regulation of TGF-Beta 1 and Fibrosis Progression	Doctor of Philosophy	Doctorate	Full Time	Mr Yike You
2012 - 2016	Principal Supervisor	Function of Latent Transforming Growth Factor-B Binding Protein-2 (LTBP-2) in Elastinogenesis and Modulation of Growth Factor Storage, Expression and Activity in Normal and Fibrotic Tissues	Doctor of Philosophy	Doctorate	Full Time	Mr Mohamed Arshad Mohamed Sideek
2005 - 2010	Principal Supervisor	Characterisation of Novel Matrix-Binding Interaction for Latent Transforming Growth Factor-Beta-Binding Protein-2, with Emphasis on Heparin and Heparan Sulphate Proteoglycans	Doctor of Philosophy	Doctorate	Full Time	Dr Mahroo Kamkar Parsi
2003 - 2006	Principal Supervisor	Molecular Interactions of Latent Transforming Growth Factor-b Binding Protein-2 (LTBP-2) with Fibrillins and Other Extracellular Matrix Macromolecules: LTBP-2 Competes with LTBP-1 for Binding to Fibrillin-1 Suggesting that LTBP-2 may Modulate Latent TGF-b Storage	Doctor of Philosophy	Doctorate	Full Time	Ms Rena Hirani

Committee Memberships

Date	Role	Committee	Institution	Country
2015 - 2015	Member	School of Medical Sciences HSW Committee	University of Adelaide	Australia
2011 - 2011	Member	School of Medical Sciences Learning and Teaching Committee	Medical Sciences, University of Adelaide	Australia
2008 - 2010	Member	Faculty of Health Sciences Small Grants Evaluation Panel	Faculty of Health Sciences, University of Adelaide	Australia
2008 - 2010	Member	NHMRC Career Development Award panel	NHMRC	Australia
2005 - 2010	Member	School of Medical Sciences Research Committee	Medical Sciences, University of Adelaide	Australia

Offices Held

Date	Office Name	Institution	Country
2015 - ongoing	Workshop Co-ordinator, Ethics, Science and Society	Medicine, University of Adelaide	Australia
2011 - ongoing	Course Co-ordinator Fundamentals in Human Nutrition	Medicine, University of Adelaide	Australia
2005 - 2010	Deputy Treasurer MBSANZ	Matrix Biology Society of Australia and New Zealand	Australia
2000 - 2005	State Representative, Executive Committee MBSANZ	Matrix Biology Society of Australia and New Zealand	Australia

Position: Visiting Research Fellow
Email: mark.gibson@adelaide.edu.au
Org Unit: Medical Specialties