Dr Marc Gladman
Marc A Gladman PhD MBBS DFFP MRCOG MRCS FRCS (Gen Surg) FRACS
Marc is a surgeon scientist. He received his degree in Medicine from King’s College in the UK and was awarded a PhD by the University of London and then went on to complete a NIHR lectureship. He trained in both obstetrics and gynaecology and general surgery in the UK, receiving his Fellowship in 2008. Previously, he held the position of Chair of Colorectal Surgery at the University of Sydney.
Each year more than 230 million major operations are performed worldwide, one for every 25 people in the world. Diseases of the bowel are among the commonest in the population, with bowel cancer being the second most common type of newly diagnosed cancer in Australia and the second biggest cancer killer. it is unclear how many operations are performed for bowel problems in Australia each year and what results are achieved following surgery.
Furthermore, bowel problems such as constipation and incontinence are one of the most frequent reasons why people visit doctors, with approximately 1 in 10 people suffering with each of these problems. Despite these staggering statistics, very little is known about how the bowel works in healthy individuals and what goes wrong in diseases and disorders such as cancer and constipation.
Marc's abiding research interest is understanding large bowel function in health and disease and its application to improve the care of the surgical patient. His research program includes integration of clinical and laboratory themes, the former spanning each of the three NIH categories of clinical research:
- Health outcomes research to objectively measure the impact of surgical interventions in patients with gastrointestinal disease in New South Wales.
- Population-based research to investigate the epidemiological basis of gastrointestinal diseases;
- Patient-orientated research involving measurement of gastrointestinal physiological function to allow the development of novel therapies; and
- T1 enteric neuroscience research aimed at better understanding the brain gut axis and its dysfunction in the clinical context of functional bowel disorders. Current studies are focused at exploring the complex interaction between the intrinsic and extrinsic innervation of the gut and relating aberrations of the enteric and autonomic nervous systems to disturbances in function.
National: Dept of Human Physiology, Flinders University, Adelaide; Menzies Centre for Health Policy; Centre for Virus Research, Westmead Institute, the University of Sydney
International: Dept of Cell & Molecular Biology, Nobel Institute, Karolinska Institute; Center for Health Outcomes & Policy, University of Michigan, USA.
|2017||Adelaide Medical School||The University of Adelaide|
|University of London||United Kingdom||PhD|
|Kings College School of Medicine||United Kingdom||MBBS|
|RCS England||United Kingdom||FRCS (Eng)|
|2017||Mirbagheri, N., Hatton, S., Ng, K., Lagopoulos, J. & GLADMAN, M. (2017). Brain responses to mechanical rectal stimuli in patients with faecal incontinence: an fMRI study. Colorectal Disease, 19, 10, 917-926.
|2017||Ng, K., Montes-Adrian, N., Mahns, D. & Gladman, M. (2017). Quantification and neurochemical coding of the myenteric plexus in humans: No regional variation between the distal colon and rectum. Neurogastroenterology and Motility, e13193-e13193.
|2017||Ng, K., Nassar, N., Soares, D., Stewart, P. & Gladman, M. (2017). Acute lower gastrointestinal haemorrhage: outcomes and risk factors for intervention in 949 emergency cases. International Journal of Colorectal Disease, 32, 9, 1327-1335.
|2017||Sirimanna, P. & Gladman, M. A. (2017). Development of a proficiency-based virtual reality simulation training curriculum for laparoscopic appendicectomy.. ANZ journal of surgery, 87, 10, 760-766.
|2016||Whiteley, I., Russell, M., Nassar, N. & Gladman, M. (2016). Outcomes of support rod usage in loop stoma formation. International Journal of Colorectal Disease, 31, 6, 1189-1195.
|2016||Ng, K. -. S., Brookes, S., Montes-Adrian, N., Mahns, D. & Gladman, M. (2016). Electrophysiological characterization of human rectal afferents. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311, 6, G1047-G1055.
|2016||Ng, K., Stewart, P. & Gladman, M. (2016). Postoperative lower gastrointestinal haemorrhage following bowel resection. ANZ Journal of Surgery, 86, 10, 836-837.
|2016||Boyce, S., Nassar, N., Lee, C., Suen, M., Zahrani, S. & Gladman, M. (2016). Young-onset colorectal cancer in New South Wales: A population-based study. Medical Journal of Australia, 205, 10, 465-470.
|2016||Mirbagheri, N., Sivakumaran, Y., Nassar, N. & Gladman, M. (2016). Systematic review of the impact of sacral neuromodulation on clinical symptoms and gastrointestinal physiology. ANZ Journal of Surgery, 86, 4, 232-236.
|2016||Mirbagheri, N., Dunn, G., Naganathan, V., Suen, M. & Gladman, M. (2016). Normal Values and Clinical Use of Bedside Sonographic Assessment of Postoperative Gastric Emptying: A Prospective Cohort Study. Diseases of the Colon and Rectum, 59, 8, 758-765.
|2015||Windsor, J., Searle, J., Hanney, R., Chapman, A., Grigg, M., Choong, P. ... Gladman, M. (2015). Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: Report from the first summit meeting. Internal Medicine Journal, 45, 9, 965-971.
|2015||Ng, K. -. S., Nassar, N., Hamd, K., Nagarajah, A. & Gladman, M. (2015). Prevalence of functional bowel disorders and faecal incontinence: an Australian primary care survey. Colorectal Disease, 17, 2, 150-159.
|2015||Windsor, J., Searle, J., Garrod, T., Hanney, R., Grigg, M., Smith, J. & Gladman, M. (2015). Developing an integrated training pathway for clinical academics: Notes from the first binational summit meeting. ANZ Journal of Surgery, 85, 6, 398-399.
|2015||Ng, K. -. S., Sivakumaran, Y., Nassar, N. & Gladman, M. (2015). Fecal incontinence: Community prevalence and associated factors - A systematic review. Diseases of the Colon and Rectum, 58, 12, 1194-1209.
|2014||Palit, S., Bhan, C., Lunniss, P., Boyle, D., Gladman, M., Knowles, C. & Scott, S. (2014). Evacuation proctography: A reappraisal of normal variability. Colorectal Disease, 16, 7, 538-546.
|2013||Ng, K. -. S., Stewart, P. & Gladman, M. (2013). Uncommon site for a common lesion. ANZ Journal of Surgery, 83, 1-2, 88-89.
|2013||Wright, D., Ng, K. -. S., Keshava, A. & Gladman, M. (2013). An unusual cause of large bowel obstruction. Colorectal Disease, 15, 1, e60-e61.
|2010||Sharma, N., Patel, M., Gladman, M., Ahmed, S. & Dorudi, S. (2010). Not one, but two, unexpected findings in a young man. The Lancet, 375, 9726, 1664-.
|2009||Lunniss, P., Gladman, M., Benninga, M. & Rao, S. (2009). Pathophysiology of evacuation disorders. Neurogastroenterology and Motility, 21, SUPPL. 2, 31-40.
|2009||Gladman, M., Aziz, Q., Scott, S., Williams, N. & Lunniss, P. (2009). Rectal hyposensitivity: Pathophysiological mechanisms. Neurogastroenterology and Motility, 21, 5, 508-e5.
|2009||Brookes, S., Dinning, P. & Gladman, M. (2009). Neuroanatomy and physiology of colorectal function and defaecation: From basic science to human clinical studies. Neurogastroenterology and Motility, 21, SUPPL. 2, 9-19.
|2009||Sharma, N., Gladman, M. & Ahmed, S. (2009). Idiopathic necrotising fasciitis. BMJ Case Reports, 2009, mar08 1, bcr0920080924-bcr0920080924.
|2008||Gladman, M. & Mukherjee, D. (2008). Electronic Clinical Challenges and Images in GI. Gastroenterology, 134, 5, e4-e6.
|2008||Zarate, N., Knowles, C., Newell, M., Garvie, N., Gladman, M., Lunniss, P. & Scott, S. (2008). In patients with slow transit constipation, the pattern of colonic transit delay does not differentiate between those with and without impaired rectal evacuation. American Journal of Gastroenterology, 103, 2, 427-434.
|2008||Scott, S. & Gladman, M. (2008). Manometric, Sensorimotor, and Neurophysiologic Evaluation of Anorectal Function. Gastroenterology Clinics of North America, 37, 3, 511-538.
|2008||Gladman, M., Haq, A. & Davies, T. (2008). The syringe test to determine the integrity of intestinal anastomoses. Annals of the Royal College of Surgeons of England, 90, 8, 696-703.
|2008||Gladman, M. & Knowles, C. (2008). Surgical Treatment of Patients with Constipation and Fecal Incontinence. Gastroenterology Clinics of North America, 37, 3, 605-625.
|2008||Gladman, M. & Sayer, G. (2008). Clinical Challenges and Images in GI. Gastroenterology, 134, 5, 1294-1636.
|2008||Gladman, M. & Knowles, C. (2008). Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel. Colorectal Disease, 10, 6, 531-538.
|2007||Gladman, M., Dvorkin, L., Scott, S., Lunniss, P. & Williams, N. (2007). A novel technique to identify patients with megarectum. Diseases of the Colon and Rectum, 50, 5, 621-629.
|2007||Gladman, M. & Shami, S. (2007). Medical mystery: An unusual complication of colonoscopy - The answer . New England Journal of Medicine, 357, 22, 2309-.
|2007||Gladman, M. & Shami, S. (2007). Medical mystery - An unusual complication of colonoscopy. New England Journal of Medicine, 357, 14, 1431-.
|2007||Vasudevan, S., Scott, S., Gladman, M. & Lunniss, P. (2007). Rectal hyposensitivity: Evaluation of anal sensation in female patients with refractory constipation with and without faecal incontinence. Neurogastroenterology and Motility, 19, 8, 660-667.
|2007||Murphy, J., Scott, S., Gladman, M. & Lunniss, P. (2007). Faecal incontinence (Br J Surg 2007; 94: 134-144) . British Journal of Surgery, 94, 6, 754-.
|2006||Gladman, M., Lunniss, P., Scott, S. & Swash, M. (2006). Rectal hyposensitivity. American Journal of Gastroenterology, 101, 5, 1140-1151.
|2005||Dvorkin, L., Gladman, M., Scott, S., Williams, N. & Lunniss, P. (2005). Rectal intussusception: A study of rectal biomechanics and visceroperception. American Journal of Gastroenterology, 100, 7, 1578-1585.
|2005||Brinkmann, D., Gladman, M., Norman, S. & Lawton, F. (2005). Why do women still develop cancer of the cervix despite the existence of a national screening programme?. European Journal of Obstetrics Gynecology and Reproductive Biology, 119, 1, 123-124.
|2005||Dvorkin, L., Gladman, M., Epstein, J., Scott, S., Williams, N. & Lunniss, P. (2005). Rectal intussusception in symptomatic patients is different from that in asymptomatic volunteers. British Journal of Surgery, 92, 7, 866-872.
|2005||Gladman, M., Williams, N., Scott, S., Ogunbiyi, O. & Lunniss, P. (2005). Medium-term results of vertical reduction rectoplasty and sigmoid colectomy for idiopathic megarectum. British Journal of Surgery, 92, 5, 624-630.
|2005||Gladman, M., Dvorkin, L., Lunniss, P., Williams, N. & Scott, S. (2005). Rectal hyposensitivity: A disorder of the rectal wall or the afferent pathway? An assessment using the barostat. American Journal of Gastroenterology, 100, 1, 106-114.
|2005||Gladman, M., Scott, S., Lunniss, P. & Williams, N. (2005). Systematic review of surgical options for idiopathic megarectum and megacolon. Annals of Surgery, 241, 4, 562-574.
|2004||Lunniss, P., Gladman, M., Hetzer, F., Williams, N. & Scott, S. (2004). Risk factors in acquired faecal incontinence. Journal of the Royal Society of Medicine, 97, 3, 111-116.
|2004||Gladman, M., Knowles, C., Gladman, L. & Payne, J. (2004). Intra-operative culture in appendicitis: Traditional practice challenged. Annals of the Royal College of Surgeons of England, 86, 3, 196-201.
|2003||Gladman, M., Scott, S., Chan, C., Williams, N. & Lunniss, P. (2003). Rectal hyposensitivity: Prevalence and clinical impact in patients with intractable constipation and fecal incontinence. Diseases of the Colon and Rectum, 46, 2, 238-246.
|2003||Gladman, M., Scott, S., Williams, N. & Lunniss, P. (2003). Clinical and physiological findings, and possible aetiological factors of rectal hyposensitivity. British Journal of Surgery, 90, 7, 860-866.
|2002||Gladman, M., MacDonald, D., Webster, J., Cook, T. & Williams, G. (2002). Renal cell carcinoma in pregnancy. Journal of the Royal Society of Medicine, 95, 4, 199-201.
|2002||Gladman, M., Scott, S., Lunniss, P. & Williams, N. (2002). Strategy for the surgical management of patients with idiopathic megarectum and megacolon (Br J Surg 2001; 88: 1392-6) . British Journal of Surgery, 89, 5, 623-.
|2002||Haq, A., Tiwari, A., Gladman, M. & Mohanna, P. (2002). A simple technique of irrigating the abdomen and pelvis through an appendicectomy wound. Annals of the Royal College of Surgeons of England, 84, 3, 211-.|
|2001||Gladman, M., Khullar, V. & Cardozo, L. (2001). First do no harm: Knowing when not to operate. Journal of Obstetrics and Gynaecology, 21, 5, 538-.
|2013||Young, C. J. & Gladman, M. A. (2013). Examination Surgery A Guide to Passing the Fellowship Examination in General Surgery. Elsevier Health Sciences.|
|2015||Gladman, M. (2015). Vertical reduction rectoplasty. In R. O'Connell, R. Madoff & M. Solomon (Eds.), Operative Surgery of the Colon, Rectum and Anus (pp. 665-671). CRC Press.|
|2013||Gladman, M. & Williams, N. (2013). Managing the megarectum. In Reconstructive Surgery of the Rectum, Anus and Perineum
|2011||Gladman, M. & Scott, S. (2011). Rectal barostat for sensory testing. In H. Parkman, R. McCallum & S. Rao (Eds.), Gastrointestinal Motility Testing: Laboratory and Office Handbook (pp. 209-222). SLACK.|
|2005||Gladman, M., Scott, S. & Williams, N. (2005). An overview. In Complex Anorectal Disorders: Investigation and Management (pp. 547-594).
Medtronic Project Grant: $70,000 - 1 year 2013
Karl Storz Research Grant: $180,000 - 3 years 2012-2015
Validity of a virtual reality simulation of laparoscopic appendicectomy: Development a proficiency-based training curriculum. Position CIA
Marc's teaching interests focus on technology-enhanced learning and incorporation of modern effective active learning pedagogies. He was an early adopter of the flipped classroom and uses experiential, team-based learning and process oriented guided inquiry learning (POGIL) in the education of medical students and postgraduate surgical and research students. He is a member of the Academy of Surgical Educators. Marc supervises PhD, MPhil, Masters and Honours students.
Postgraduate and Undergraduate Teaching
He developed and designed the successful Surgical Masterclass and 3 course units for the Masters of Surgery at the University of Sydney. Currently, he is co-cordinator for Bachelor of Nursing 2005 & 2008: Biology of Human Disease and a tutor for MBBS Unit 3101A and B - Scientific Basis of Medicine III.
Marc has written numerous surgical and career development books, including the highly acclaimed “Examination Surgery: A Guide to Passing the FRACS in General Surgery” and “Clinical Cases and OSCEs in Surgery: The Definitive Guide to Passing Examinations”, which is now in its third edition and has won recognition at the British Medical Association international book awards. He has also designed websites for surgical education: e.g. masterclass.surgery
Postgraduate Student Supervision
- 2017, Dr Kheng-Seong Ng. The Human Rectum: Innervation in Health & Impact of Surgery on Function. Primary supervisor. University of Sydney
- 2017, Dr Naseem Mirbagheri. Acute & Chronic Effects of Sacral Neuromodulation in Patients with Faecal Incontinence. Primary supervisor. University of Sydney
- 2015, Dr Ali Al Yami. The Impact of Postoperative Adhesions: A Cohort Study of Adhesion-Related Admissions Following Abdominal Surgery in NSW 2005-2010. Primary supervisor. University of Sydney
- 2015, Dr Saleh E Al Zahrani. Young-Onset Colorectal Cancer in Australia: A Population-Based Study. Primary supervisor. University of Sydney
|2017 - ongoing||Member||Academy of Surgical Educators|
|2014 - ongoing||Member||Section of Colon & Rectal Surgeons, RACS|
|2013 - ongoing||Member||Colorectal Surgical Society of Australia & New Zealand||Australia|
|2015 - ongoing||Member||Section of Academic Surgery, RACS|
|Date||Role||Editorial Board Name||Country|
|2016 - ongoing||Board Member||Medical Journal of Australia|
|2015 - ongoing||Cancer Australia||National Cancer Control Indicators framework||Health services and related|