Dr Marc Gladman

Marc Gladman
Adelaide Medical School
Faculty of Health and Medical Sciences

Marc A Gladman PhD MBBS DFFP MRCOG MRCS FRCS (Gen Surg) FRACS

Marc is a surgeon scientist. He received his degree in Medicine from King’s College in the UK and was awarded a PhD by the University of London and then went on to complete a NIHR lectureship. He trained in both obstetrics and gynaecology and general surgery in the UK, receiving his Fellowship in 2008. Previously, he held the position of Chair of Colorectal Surgery at the University of Sydney.

Each year more than 230 million major operations are performed worldwide, one for every 25 people in the world. Diseases of the bowel are among the commonest in the population, with bowel cancer being the second most common type of newly diagnosed cancer in Australia and the second biggest cancer killer. it is unclear how many operations are performed for bowel problems in Australia each year and what results are achieved following surgery.

Furthermore, bowel problems such as constipation and incontinence are one of the most frequent reasons why people visit doctors, with approximately 1 in 10 people suffering with each of these problems. Despite these staggering statistics, very little is known about how the bowel works in healthy individuals and what goes wrong in diseases and disorders such as cancer and constipation.

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Dr Marc Gladman

Marc A Gladman PhD MBBS DFFP MRCOG MRCS FRCS (Gen Surg) FRACS

Marc is a surgeon scientist. He received his degree in Medicine from King’s College in the UK and was awarded a PhD by the University of London and then went on to complete a NIHR lectureship. He trained in both obstetrics and gynaecology and general surgery in the UK, receiving his Fellowship in 2008. Previously, he held the position of Chair of Colorectal Surgery at the University of Sydney.

Each year more than 230 million major operations are performed worldwide, one for every 25 people in the world. Diseases of the bowel are among the commonest in the population, with bowel cancer being the second most common type of newly diagnosed cancer in Australia and the second biggest cancer killer. it is unclear how many operations are performed for bowel problems in Australia each year and what results are achieved following surgery.

Furthermore, bowel problems such as constipation and incontinence are one of the most frequent reasons why people visit doctors, with approximately 1 in 10 people suffering with each of these problems. Despite these staggering statistics, very little is known about how the bowel works in healthy individuals and what goes wrong in diseases and disorders such as cancer and constipation.

Marc's abiding research interest is understanding large bowel function in health and disease and its application to improve the care of the surgical patient. His research program includes integration of clinical and laboratory themes, the former spanning each of the three NIH categories of clinical research:

  1. Health outcomes research to objectively measure the impact of surgical interventions in patients with gastrointestinal disease in New South Wales.
  2. Population-based research to investigate the epidemiological basis of gastrointestinal diseases;
  3. Patient-orientated research involving measurement of gastrointestinal physiological function to allow the development of novel therapies; and
  4. T1 enteric neuroscience research aimed at better understanding the brain gut axis and its dysfunction in the clinical context of functional bowel disorders. Current studies are focused at exploring the complex interaction between the intrinsic and extrinsic innervation of the gut and relating aberrations of the enteric and autonomic nervous systems to disturbances in function.

Established collaborations:

National: Dept of Human Physiology, Flinders University, Adelaide; Menzies Centre for Health Policy; Centre for Virus Research, Westmead Institute, the University of Sydney

International: Dept of Cell & Molecular Biology, Nobel Institute, Karolinska Institute; Center for Health Outcomes & Policy, University of Michigan, USA.

Appointments

Date Position Institution name
2017 Adelaide Medical School The University of Adelaide

Education

Date Institution name Country Title
Kings College School of Medicine United Kingdom MBBS
University of London United Kingdom PhD
RACS Australia FRACS
RCOG United Kingdom MRCOG
RCS England United Kingdom FRCS (Eng)

Keywords

Clinical Sciences, Education, Gastroenterology & Hepatology, Medical Physiology, Mortality, Surgery

Journals

Date Citation
2017 Mirbagheri,N, Hatton,S, Ng,K, Lagopoulos,J, GLADMAN,M, 2017, Brain responses to mechanical rectal stimuli in patients with faecal incontinence: an fMRI study, Colorectal Disease, OnlinePubl, 1-27 10.1111/codi.13694
2017 Siramanna,P, Gladman,M, 2017, Development of a proficiency-based virtual reality simulation training curriculum for laparoscopic appendicectomy, ANZ Journal of Surgery, - 10.1111/ans.14135
2017 Ng,K-S, Nassar,N, Soares,D, Stewart,P, Gladman,MA, 2017, Acute lower gastrointestinal haemorrhage: outcomes and risk factors for intervention in 949 emergency cases., International journal of colorectal disease, - 10.1007/s00384-017-2844-2
2016 Boyce,S, Nassar,N, Lee,C, Suen,M, Zahrani,S, Gladman,M, 2016, Young-onset colorectal cancer in New South Wales: A population-based study, Medical Journal of Australia, 205, 10, 465-470 10.5694/mja16.00237
2016 Ng,K-S, Brookes,S, Montes-Adrian,N, Mahns,D, Gladman,M, 2016, Electrophysiological characterization of human rectal afferents, American Journal of Physiology - Gastrointestinal and Liver Physiology, 311, 6, G1047-G1055 10.1152/ajpgi.00153.2016
2016 Ng,K, Stewart,P, Gladman,M, 2016, Postoperative lower gastrointestinal haemorrhage following bowel resection, ANZ Journal of Surgery, 86, 10, 836-837 10.1111/ans.12766
2016 Whiteley,I, Russell,M, Nassar,N, Gladman,M, 2016, Outcomes of support rod usage in loop stoma formation, International Journal of Colorectal Disease, 31, 6, 1189-1195 10.1007/s00384-016-2569-7
2016 Mirbagheri,N, Dunn,G, Naganathan,V, Suen,M, Gladman,M, 2016, Normal Values and Clinical Use of Bedside Sonographic Assessment of Postoperative Gastric Emptying: A Prospective Cohort Study, Diseases of the Colon and Rectum, 59, 8, 758-765 10.1097/DCR.0000000000000637
2016 Mirbagheri,N, Sivakumaran,Y, Nassar,N, Gladman,M, 2016, Systematic review of the impact of sacral neuromodulation on clinical symptoms and gastrointestinal physiology, ANZ Journal of Surgery, 86, 4, 232-236 10.1111/ans.13257
2015 Ng,K-S, Sivakumaran,Y, Nassar,N, Gladman,M, 2015, Fecal incontinence: Community prevalence and associated factors - A systematic review, Diseases of the Colon and Rectum, 58, 12, 1194-1209 10.1097/DCR.0000000000000514
2015 Ng,K-S, Nassar,N, Hamd,K, Nagarajah,A, Gladman,M, 2015, Prevalence of functional bowel disorders and faecal incontinence: an Australian primary care survey, Colorectal Disease, 17, 2, 150-159 10.1111/codi.12808
2015 Windsor,J, Searle,J, Garrod,T, Hanney,R, Grigg,M, Smith,J, Gladman,M, 2015, Developing an integrated training pathway for clinical academics: Notes from the first binational summit meeting, ANZ Journal of Surgery, 85, 6, 398-399 10.1111/ans.13119
2015 Windsor,J, Searle,J, Hanney,R, Chapman,A, Grigg,M, Choong,P, Mackay,A, Smithers,B, Churchill,J, Carney,S et al, 2015, Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: Report from the first summit meeting, Internal Medicine Journal, 45, 9, 965-971 10.1111/imj.12854
2014 Palit,S, Bhan,C, Lunniss,P, Boyle,D, Gladman,M, Knowles,C, Scott,S, 2014, Evacuation proctography: A reappraisal of normal variability, Colorectal Disease, 16, 7, 538-546 10.1111/codi.12595
2013 Wright,D, Ng,K-S, Keshava,A, Gladman,M, 2013, An unusual cause of large bowel obstruction, Colorectal Disease, 15, 1, e60-e61 10.1111/j.1463-1318.2012.03085.x
2013 Ng,K-S, Stewart,P, Gladman,M, 2013, Uncommon site for a common lesion, ANZ Journal of Surgery, 83, 1-2, 88-89 10.1111/ans.12021
2010 Sharma,N, Patel,M, Gladman,M, Ahmed,S, Dorudi,S, 2010, Not one, but two, unexpected findings in a young man, The Lancet, 375, 9726, 1664- 10.1016/S0140-6736(10)60321-2
2009 Sharma,N, Gladman,M, Ahmed,S, 2009, Idiopathic necrotising fasciitis, BMJ Case Reports, 2009, mar08 1, bcr0920080924-bcr0920080924 10.1136/bcr.09.2008.0924
2009 Brookes,S, Dinning,P, Gladman,M, 2009, Neuroanatomy and physiology of colorectal function and defaecation: From basic science to human clinical studies, Neurogastroenterology and Motility, 21, SUPPL. 2, 9-19 10.1111/j.1365-2982.2009.01400.x
2009 Lunniss,P, Gladman,M, Benninga,M, Rao,S, 2009, Pathophysiology of evacuation disorders, Neurogastroenterology and Motility, 21, SUPPL. 2, 31-40 10.1111/j.1365-2982.2009.01402.x
2009 Gladman,M, Aziz,Q, Scott,S, Williams,N, Lunniss,P, 2009, Rectal hyposensitivity: Pathophysiological mechanisms, Neurogastroenterology and Motility, 21, 5, 508-e5 10.1111/j.1365-2982.2008.01216.x
2008 Gladman,M, Haq,A, Davies,T, 2008, The syringe test to determine the integrity of intestinal anastomoses, Annals of the Royal College of Surgeons of England, 90, 8, 696-703 10.1308/003588408X321774
2008 Gladman,M, Knowles,C, 2008, Surgical Treatment of Patients with Constipation and Fecal Incontinence, Gastroenterology Clinics of North America, 37, 3, 605-625 10.1016/j.gtc.2008.06.009
2008 Gladman,M, Mukherjee,D, 2008, Electronic Clinical Challenges and Images in GI, Gastroenterology, 134, 5, e4-e6 10.1053/j.gastro.2008.03.054
2008 Scott,S, Gladman,M, 2008, Manometric, Sensorimotor, and Neurophysiologic Evaluation of Anorectal Function, Gastroenterology Clinics of North America, 37, 3, 511-538 10.1016/j.gtc.2008.06.010
2008 Gladman,M, Sayer,G, 2008, Clinical Challenges and Images in GI, Gastroenterology, 134, 5, 1294-1636 10.1053/j.gastro.2008.03.049
2008 Gladman,M, Knowles,C, 2008, Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel, Colorectal Disease, 10, 6, 531-538 10.1111/j.1463-1318.2007.01457.x
2008 Zarate,N, Knowles,C, Newell,M, Garvie,N, Gladman,M, Lunniss,P, Scott,S, 2008, In patients with slow transit constipation, the pattern of colonic transit delay does not differentiate between those with and without impaired rectal evacuation, American Journal of Gastroenterology, 103, 2, 427-434 10.1111/j.1572-0241.2007.01675.x
2007 Vasudevan,S, Scott,S, Gladman,M, Lunniss,P, 2007, Rectal hyposensitivity: Evaluation of anal sensation in female patients with refractory constipation with and without faecal incontinence, Neurogastroenterology and Motility, 19, 8, 660-667 10.1111/j.1365-2982.2007.00922.x
2007 Gladman,M, Dvorkin,L, Scott,S, Lunniss,P, Williams,N, 2007, A novel technique to identify patients with megarectum, Diseases of the Colon and Rectum, 50, 5, 621-629 10.1007/s10350-006-0805-x
2007 Gladman,M, Shami,S, 2007, Medical mystery - An unusual complication of colonoscopy, New England Journal of Medicine, 357, 14, 1431- 10.1056/NEJMicm066934
2007 Gladman,M, Shami,S, 2007, Medical mystery: An unusual complication of colonoscopy - The answer [10], New England Journal of Medicine, 357, 22, 2309- 10.1056/NEJMc076437
2007 Murphy,J, Scott,S, Gladman,M, Lunniss,P, 2007, Faecal incontinence (Br J Surg 2007; 94: 134-144) [1], British Journal of Surgery, 94, 6, 754- 10.1002/bjs.5895
2006 Gladman,M, Lunniss,P, Scott,S, Swash,M, 2006, Rectal hyposensitivity, American Journal of Gastroenterology, 101, 5, 1140-1151 10.1111/j.1572-0241.2006.00604.x
2005 Brinkmann,D, Gladman,M, Norman,S, Lawton,F, 2005, Why do women still develop cancer of the cervix despite the existence of a national screening programme?, European Journal of Obstetrics Gynecology and Reproductive Biology, 119, 1, 123-124 10.1016/j.ejogrb.2004.07.021
2005 Dvorkin,L, Gladman,M, Scott,S, Williams,N, Lunniss,P, 2005, Rectal intussusception: A study of rectal biomechanics and visceroperception, American Journal of Gastroenterology, 100, 7, 1578-1585 10.1111/j.1572-0241.2005.41114.x
2005 Gladman,M, Scott,S, Lunniss,P, Williams,N, 2005, Systematic review of surgical options for idiopathic megarectum and megacolon, Annals of Surgery, 241, 4, 562-574 10.1097/01.sla.0000157140.69695.d3
2005 Gladman,M, Williams,N, Scott,S, Ogunbiyi,O, Lunniss,P, 2005, Medium-term results of vertical reduction rectoplasty and sigmoid colectomy for idiopathic megarectum, British Journal of Surgery, 92, 5, 624-630 10.1002/bjs.4918
2005 Dvorkin,L, Gladman,M, Epstein,J, Scott,S, Williams,N, Lunniss,P, 2005, Rectal intussusception in symptomatic patients is different from that in asymptomatic volunteers, British Journal of Surgery, 92, 7, 866-872 10.1002/bjs.4912
2005 Gladman,M, Dvorkin,L, Lunniss,P, Williams,N, Scott,S, 2005, Rectal hyposensitivity: A disorder of the rectal wall or the afferent pathway? An assessment using the barostat, American Journal of Gastroenterology, 100, 1, 106-114 10.1111/j.1572-0241.2005.40021.x
2004 Gladman,M, Knowles,C, Gladman,L, Payne,J, 2004, Intra-operative culture in appendicitis: Traditional practice challenged, Annals of the Royal College of Surgeons of England, 86, 3, 196-201 10.1308/003588404323043346
2004 Lunniss,P, Gladman,M, Hetzer,F, Williams,N, Scott,S, 2004, Risk factors in acquired faecal incontinence, Journal of the Royal Society of Medicine, 97, 3, 111-116 10.1258/jrsm.97.3.111
2003 Gladman,M, Scott,S, Williams,N, Lunniss,P, 2003, Clinical and physiological findings, and possible aetiological factors of rectal hyposensitivity, British Journal of Surgery, 90, 7, 860-866 10.1002/bjs.4103
2003 Gladman,M, Scott,S, Chan,C, Williams,N, Lunniss,P, 2003, Rectal hyposensitivity: Prevalence and clinical impact in patients with intractable constipation and fecal incontinence, Diseases of the Colon and Rectum, 46, 2, 238-246 10.1007/s10350-004-6529-x
2002 Haq,A, Tiwari,A, Gladman,M, Mohanna,P, 2002, A simple technique of irrigating the abdomen and pelvis through an appendicectomy wound, Annals of the Royal College of Surgeons of England, 84, 3, 211-
2002 Gladman,M, MacDonald,D, Webster,J, Cook,T, Williams,G, 2002, Renal cell carcinoma in pregnancy, Journal of the Royal Society of Medicine, 95, 4, 199-201 10.1258/jrsm.95.4.199
2002 Gladman,M, Scott,S, Lunniss,P, Williams,N, 2002, Strategy for the surgical management of patients with idiopathic megarectum and megacolon (Br J Surg 2001; 88: 1392-6) [1], British Journal of Surgery, 89, 5, 623- 10.1046/j.1365-2168.2002.02092.x
2001 Gladman,M, Khullar,V, Cardozo,L, 2001, First do no harm: Knowing when not to operate, Journal of Obstetrics and Gynaecology, 21, 5, 538- 10.1080/01443610120073954

Book Chapters

Date Citation
2013 Gladman,M, Williams,N, 2013, Managing the megarectum 10.1007/978-1-84882-413-3_25
2005 Gladman,M, Scott,S, Williams,N, 2005, An overview, pp. 547-594 10.1007/1-84628-057-5_29

Medtronic Project Grant: $70,000 - 1 year                                                    2013

Karl Storz Research Grant: $180,000 - 3 years                                            2012-2015

Validity of a virtual reality simulation of laparoscopic appendicectomy:  Development a proficiency-based training curriculum. Position CIA

Teaching Interests

Marc's teaching interests focus on technology-enhanced learning and incorporation of modern effective active learning pedagogies. He was an early adopter of the flipped classroom and uses experiential, team-based learning and process oriented guided inquiry learning (POGIL) in the education of medical students and postgraduate surgical and research students. He is a member of the Academy of Surgical Educators. Marc supervises PhD, MPhil, Masters and Honours  students.

Postgraduate and Undergraduate Teaching

He developed and designed the successful Surgical Masterclass and 3 course units for the Masters of Surgery at the University of Sydney. Currently, he is co-cordinator for Bachelor of Nursing 2005 & 2008: Biology of Human Disease and a tutor for MBBS Unit 3101A and B  - Scientific Basis of Medicine III.

Marc has written numerous surgical and career development books, including the highly acclaimed “Examination Surgery: A Guide to Passing the FRACS in General Surgery” and “Clinical Cases and OSCEs in Surgery: The Definitive Guide to Passing Examinations”, which is now in its third edition and has won recognition at the British Medical Association international book awards. He has also designed websites for surgical education: e.g. masterclass.surgery

 

Postgraduate Student Supervision

PhD

  • 2017, Dr Kheng-Seong Ng. The Human Rectum: Innervation in Health & Impact of Surgery on Function. Primary supervisor. University of Sydney
  • 2017, Dr Naseem Mirbagheri. Acute & Chronic Effects of Sacral Neuromodulation in Patients with Faecal Incontinence. Primary supervisor. University of Sydney

Masters

  • 2015, Dr Ali Al Yami. The Impact of Postoperative Adhesions: A Cohort Study of Adhesion-Related Admissions Following Abdominal Surgery in NSW 2005-2010. Primary supervisor. University of Sydney
  • 2015, Dr Saleh E Al Zahrani. Young-Onset Colorectal Cancer in Australia: A Population-Based Study. Primary supervisor. University of Sydney

 

 

 

Memberships

Date Role Membership Country
2017 Member Academy of Surgical Educators
2014 Member Section of Colon & Rectal Surgeons, RACS
2013 Member Colorectal Surgical Society of Australia & New Zealand Australia

Committee Memberships

Date Role Committee Institution Country
2015 Member Section of Academic Surgery, RACS

Editorial Boards

Date Role Editorial Board Name Country
2016 Board Member Medical Journal of Australia

Consulting/Advisories

Date Institution Department Organisation Type Country
2015 Cancer Australia National Cancer Control Indicators framework Health services and related
Phone
83135035
Campus
North Terrace
Building
Medical School South
Room Number
5 19a
Org Unit
Adelaide Medical School

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