Dr Mahnaz Ramezanpour
Grant-Funded Researcher (A)
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Mahnaz Ramezanpour is a biomedical researcher that completed her PhD in medical biotechnology in 2015 at Flinders University, Australia and authored > 42 peer-reviewed articles and 1 book chapter.
Her research program largely focuses on evaluating causes of chronic rhinosinusitis (CRS), identifying new diagnostic markers and treatment strategies to the benefit of CRS patients. She collaborates widely in multidisciplinary teams of scientists, clinicians and industry partners to ensure a real-world impact of her work. She collaborated with two large biotech companies, investigating the effect of several of their commercial products on the mucosal barrier function. As lead investigator, her research has led to the development of new soon to be released medical treatments for CRS.
Recently, she is using the state-of-the-art stem cell and organoid technologies for establishing airway organoids. The stem cell based organoid technology allows the culturing and expansion of a patient’s own cells in vitro in order to test and select the most effective and least toxic drug combination. She has established and characterized the nasal organoids derived from CRS patients. She is using cells, macrophages, and clinical bacteria isolates from CRS patients to evaluate and compare the effective capacity and immune response pathways of infection in the nasal organoids. Her research focus is on developing effective treatments against CRS patients and translating them from the lab to real-life applications.
Available projects for HDR, Honours and 3rd Year students in 2022 include:
1) Investigating new therapeutic targets to personalise treatment for CRS patients with recurrent disease.
2) The use of nasal organoids as a valid alternative model for lung organoids.
- My Research
- Career
- Publications
- Grants and Funding
- Teaching
- Supervision
- Professional Activities
- Contact
Investigating new therapeutic targets to personalise treatment for CRS patients with recurrent disease.
The use of nasal organoids as a valid alternative model for lung organoids.
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Language Competencies
Language Competency Persian Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 2011 - 2015 Flinders University Australia PhD University of Adelaide, Adelaide Australia Postdoctoral fellow -
Research Interests
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Journals
Year Citation 2024 Cherian, L. M., Liu, S., Hon, K., Ramezanpour, M., Hu, H., Javadiyan, S., . . . Vreugde, S. (2024). Hydrocortisone metabolism by Staphylococcus: Effects on anti-inflammatory and antimicrobial action. International Forum of Allergy and Rhinology, 14(3), 711-715.
2023 Feizi, S., Cooksley, C. M., Ramezanpour, M., Nepal, R., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2023). Colloidal silver against macrophage infections and biofilms of atypical mycobacteria. BioMetals, 36(4), 913-925.
Scopus2 WoS1 Europe PMC12023 Dhakal, B., Li, C. M. Y., Ramezanpour, M., Houtak, G., Li, R., Bouras, G., . . . Fenix, K. (2023). Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation. Frontiers in Immunology, 14, 13 pages.
Scopus3 WoS1 Europe PMC22022 Menberu, M. A., Cooksley, C., Ramezanpour, M., Bouras, G., Wormald, P. -J., Psaltis, A. J., & Vreugde, S. (2022). In vitro and in vivo evaluation of probiotic properties of Corynebacterium accolens isolated from the human nasal cavity. Microbiological Research, 255, 10 pages.
Scopus5 WoS1 Europe PMC32022 Javadiyan, S., Germein, K. C., Cooksley, C. M., Ramezanpour, M., Singh, N., Wormald, P. -J., . . . Psaltis, A. J. (2022). In Vitro safety and anti-bacterial efficacy assessment of Acriflavine.. Allergy, 77(6), 1917-1920.
2022 Mahnaz, R., Harrison, B., Hon, K., Gohar, S., Hadi, R., Aaron, F. K., . . . Sarah, V. (2022). Characterization of human nasal organoids from chronic rhinosinusitis patients.. Biology open, 11(8), 1-8.
Scopus1 WoS12022 Shaghayegh, G., Cooksley, C., Ramezanpour, M., Wormald, P. -J., Psaltis, A. J., & Vreugde, S. (2022). Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity. Biomedicines, 10(6), 1-28.
Scopus13 WoS5 Europe PMC72021 Suzuki, M., Cooksley, C., Suzuki, T., Ramezanpour, M., Nakazono, A., Nakamaru, Y., . . . Vreugde, S. (2021). TLR Signals in Epithelial Cells in the Nasal Cavity and Paranasal Sinuses. Frontiers in Allergy, 2, 780425-1-780425-11.
Scopus7 WoS2 Europe PMC22021 Kao, S., Bassiouni, A., Ramezanpour, M., Finnie, J., Chegeni, N., Colella, A. D., . . . Psaltis, A. J. (2021). Proteomic analysis of nasal mucus samples of healthy and chronic rhinosinusitis patients. J Allergy Clin Immunol, 147(1), 168-178.
Scopus27 WoS22 Europe PMC152021 Suzuki, M., Ramezanpour, M., Cooksley, C., Ogi, K., Psaltis, A. J., Nakamaru, Y., . . . Vreugde, S. (2021). Metallothionein-3 is a clinical biomarker for tissue zinc levels in nasal mucosa. Auris Nasus Larynx, 48(5), 890-897.
Scopus3 WoS1 Europe PMC32021 Rastin, H., Ramezanpour, M., Hassan, K., Mazinani, A., Tung, T. T., Vreugde, S., & Losic, D. (2021). 3D bioprinting of a cell-laden antibacterial polysaccharide hydrogel composite. Carbohydrate Polymers, 264, 117989-1-117989-12.
Scopus51 WoS42 Europe PMC192021 Nakazono, A., Nakamaru, Y., Ramezanpour, M., Kondo, T., Watanabe, M., Hatakeyama, S., . . . Homma, A. (2021). Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells. Frontiers in Cellular and Infection Microbiology, 11, 1-10.
Scopus11 WoS11 Europe PMC82021 Tuli, J. F., Ramezanpour, M., Cooksley, C., Psaltis, A. J., Wormald, P. -J., & Vreugde, S. (2021). Association between mucosal barrier disruption by Pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis.. Allergy, 76(11), 3459-3469.
Scopus19 WoS12 Europe PMC122021 Ramezanpour, M., Bolt, H., Hon, K., Bouras, G. S., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2021). Cytokine-induced modulation of sars-cov2 receptor expression in primary human nasal epithelial cells. Pathogens, 10(7), 18 pages.
Scopus2 WoS2 Europe PMC22021 Ramezanpour, M., Ogi, K., Liu, S., Tuli, J. F., Bennett, C., Masanobu, S., . . . Vreugde, S. (2021). Der p 1 disrupts the epithelial barrier and induces IL-6 production in patients with house dust mite allergic rhinitis. Frontiers in Allergy, 2, 1-9.
Scopus8 WoS5 Europe PMC52021 Rastin, H., Mansouri, N., Tung, T. T., Hassan, K., Mazinani, A., Ramezanpour, M., . . . Losic, D. (2021). Converging 2D nanomaterials and 3D bioprinting technology: state-of-the-art, challenges, and potential outlook in biomedical applications. Advanced Healthcare Materials, 10(22), e2101439-1-e2101439-50.
Scopus13 WoS9 Europe PMC22021 Ogi, K., Liu, S., Ramezanpour, M., Cooksley, C., Javadiyan, S., Fujieda, S., . . . Psaltis, A. J. (2021). Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells. Toxicology Letters, 353, 27-33.
Scopus4 WoS2 Europe PMC22020 Dong, D., Thomas, N., Ramezanpour, M., Alkis, P., Huang, S., Zhao, Y., . . . Vreudge, S. (2020). Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations. Experimental Biology and Medicine, 245(1), 34-41.
Scopus14 WoS14 Europe PMC62020 Paramasivan, S., Bassiouni, A., Shiffer, A., Dillon, M. R., Cope, E. K., Cooksley, C., . . . Psaltis, A. J. (2020). The international sinonasal microbiome study (ISMS): a multi-centre, multi-national characterization of sinonasal bacterial ecology. Allergy, 75(8), 2033-2045.
Scopus46 WoS38 Europe PMC242020 Gouzos, M., Ramezanpour, M., Bassiouni, A., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2020). Antibiotics affect ROS production and fibroblast migration in an in-vitro model of sinonasal wound healing. Frontiers in Cellular and Infection Microbiology, 10, 110-1-110-12.
Scopus16 WoS8 Europe PMC92020 Bassiouni, A., Paramasivan, S., Shiffer, A., Dillon, M. R., Cope, E. K., Cooksley, C., . . . Psaltis, A. J. (2020). Microbiotyping the Sinonasal Microbiome.. Frontiers in Cellular and Infection Microbiology, 10, 137.
Scopus19 WoS12 Europe PMC92020 Goggin, R., Bennett, C., Ramezanpour, M., Hu, H., Fenix, K., Bassiouni, A., . . . Vreugde, S. (2020). Association between viral infection and increased mucosal eosinophils and CD8<sup>+</sup>CD103<sup>+</sup> T cells in chronic rhinosinusitis. International Forum of Allergy and Rhinology, 10(8), 978-980.
2020 Ramezanpour, M., Smith, J. P., Pstaltis, A. J., Wormald, P. J., & Vreugde, S. (2020). In vitro safety evaluation of a povidone‐iodine solution applied to human nasal epithelial cells. International Forum of Allergy and Rhinology, 10(10), 1141-1148.
Scopus28 WoS23 Europe PMC142020 Ramezanpour, M., Kao, S., Bassiouni, A., Chegeni, N., Colella, A., Chataway, K., . . . Psaltis, A. (2020). Scoping review of chronic rhinosinusitis proteomicsc rhinosinusitis proteomics. Rhinology, 58(5), 418-470.
2020 Panchatcharam, B. S., Cooksley, C. M., Ramezanpour, M., Vediappan, R. S., Bassiouni, A., Wormald, P. J., . . . Vreugde, S. (2020). Staphylococcus aureus biofilm exoproteins are cytotoxic to human nasal epithelial barrier in Chronic Rhinosinusitis. International Forum of Allergy and Rhinology, 10(7), 871-883.
Scopus19 WoS14 Europe PMC82020 Kao, S. S. -T., Bassiouni, A., Ramezanpour, M., Chegeni, N., Colella, A. D., Chataway, T. K., . . . Psaltis, A. J. (2020). Scoping review of chronic rhinosinusitis proteomics.. Rhinology, 58(5), 418-470.
Scopus12 WoS9 Europe PMC52020 Ramezanpour, M., Hu, H., Lau, A., Liu, S., De Silva, A., Bolt, H., . . . Vreugde, S. (2020). Increased serum IgG4 associates with asthma and tissue eosinophilia in chronic rhinosinusitis patients. Pathogens, 9(10), 1-6.
Scopus2 WoS1 Europe PMC12020 Suzuki, M., Ramezanpour, M., Cooksley, C., Lee, T. J., Jeong, B., Kao, S., . . . Vreugde, S. (2020). Zinc-depletion associates with tissue eosinophilia and collagen depletion in chronic rhinosinusitis. Rhinology, 58(5), 451-459.
Scopus10 WoS3 Europe PMC22020 Kao, S. S. T., Ramezanpour, M., Bassiouni, A., Finnie, J., Wormald, P. J., Vreugde, S., & Psaltis, A. J. (2020). Barrier disruptive effects of mucus isolated from chronic rhinosinusitis patients. Allergy: European Journal of Allergy and Clinical Immunology, 75(1), 3 pages.
Scopus12 WoS13 Europe PMC52019 Kao, S. S. T., Ramezanpour, M., Bassiouni, A., Wormald, P. J., Psaltis, A. J., & Vreugde, S. (2019). The effect of neutrophil serine proteases on human nasal epithelial cell barrier function. International Forum of Allergy and Rhinology, 9(10), 7 pages.
Scopus28 WoS20 Europe PMC172019 Hu, H., Ramezanpour, M., Hayes, A. J., Liu, S., Psaltis, A. J., Wormald, P., & Vreugde, S. (2019). Sub-Inhibitory Clindamycin and Azithromycin reduce S. aureus Exoprotein Induced Toxicity, Inflammation, Barrier Disruption and Invasion.. Journal of clinical medicine, 8(10), 16 pages.
Scopus16 WoS14 Europe PMC122019 Murphy, J., Ramezanpour, M., Drilling, A., Roscioli, E., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2019). In vitro characteristics of an airway barrier-disrupting factor secreted by Staphylococcus aureus. International Forum of Allergy and Rhinology, 9(2), 187-196.
Scopus11 WoS9 Europe PMC72019 Ramezanpour, M., Bolt, H., Psaltis, A., Wormald, P. J., & Vreugde, S. (2019). Inducing a Mucosal Barrier–Sparing Inflammatory Response in Laboratory-Grown Primary Human Nasal Epithelial Cells. Current Protocols in Toxicology, 80(1), e69.
Scopus14 Europe PMC52019 Cherian, L. M., Cooksley, C., Richter, K., Ramezanpour, M., Paramasivan, S., Wormald, P. J., . . . Psaltis, A. J. (2019). Effect of commercial nasal steroid preparation on bacterial growth. International Forum of Allergy and Rhinology, 9(7), 766-775.
Scopus8 WoS7 Europe PMC22019 Paramasivan, S., Bassiouni, A., Shiffer, A., Dillon, M., Cope, E., Cooksley, C., . . . Psaltis, A. (2019). The international sinonasal microbiome study (ISMS): a multi-centre, multi-national collaboration characterising the microbial ecology of the sinonasal cavity.
2019 Ramezanpour, M., Smith, J. L. P., Ooi, M. L., Gouzos, M., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2019). Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro. Scientific Reports, 9(1), 9 pages.
Scopus18 WoS12 Europe PMC132019 Li, J., Ramezanpour, M., Fong, S. A., Cooksley, C., Murphy, J., Suzuki, M., . . . Vreugde, S. (2019). Pseudomonas aeruginosa exoprotein-induced barrier disruption correlates with elastase activity and marks Chronic Rhinosinusitis severity. Frontiers in Cellular and Infection Microbiology, 9, 9 pages.
Scopus27 WoS20 Europe PMC152019 Bennett, C., Ramezanpour, M., Cooksley, C., Vreugde, S., & Psaltis, A. J. (2019). Kappa-carrageenan sinus rinses reduce inflammation and intracellular Staphylococcus aureus infection in airway epithelial cells. International Forum of Allergy and Rhinology, 9(8), 918-925.
Scopus8 WoS7 Europe PMC32018 Murphy, J., Ramezanpour, M., Stach, N., Dubin, G., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro. Laryngoscope, 128(1), 8-15.
Scopus42 WoS31 Europe PMC202018 Suzuki, M., Ramezanpour, M., Cooksley, C., Li, J., Nakamaru, Y., Homma, A., . . . Vreugde, S. (2018). Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells. American journal of respiratory cell and molecular biology, 59(4), 500-510.
Scopus16 WoS16 Europe PMC102018 Murphy, J., Ramezanpour, M., Roscioli, E., Psaltis, A. J., Wormald, P. J., & Vreugde, S. (2018). Mucosal zinc deficiency in chronic rhinosinusitis with nasal polyposis contributes to barrier disruption and decreases ZO-1. Allergy: European Journal of Allergy and Clinical Immunology, 73(10), 2095-2097.
Scopus21 WoS18 Europe PMC62018 Ramezanpour, M., Bolt, H., Psaltis, A., Wormald, P., & Vreugde, S. (2018). Primary human nasal epithelial cells: a source of poly (I:C) LMW-induced IL-6 production. Scientific Reports, 8(1), 8 pages.
Scopus24 WoS19 Europe PMC182017 Ramezanpour, M., Murphy, J., Smith, J., Vreugde, S., & Psaltis, A. (2017). In vitro safety evaluation of human nasal epithelial cell monolayers exposed to carrageenan sinus wash. International Forum of Allergy and Rhinology, 7(12), 1170-1177.
Scopus23 WoS19 Europe PMC62017 Oue, S., Ramezanpour, M., Paramasivan, S., Miljkovic, D., Cooksley, C. M., Bassiouni, A., . . . Vreugde, S. (2017). Increased IL-13 expression is independently associated with neo-osteogenesis in patients with chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 140(5), 1444-1448.e11.
Scopus11 WoS11 Europe PMC62017 Richter, K., Facal, P., Thomas, N., Vandecandelaere, I., Ramezanpour, M., Cooksley, C., . . . Vreugde, S. (2017). Taking the silver bullet colloidal silver particles for the topical treatment of biofilm-related infections. ACS Applied Materials and Interfaces, 9(26), 21631-21638.
Scopus45 WoS40 Europe PMC182017 Ramezanpour, M., Rayan, A., Smith, J., & Vreugde, S. (2017). The effect of topical treatments for CRS on the sinonasal epithelial barrier. Rhinology, 55(2), 161-169.
Scopus13 WoS11 Europe PMC52016 Richter, K., Ramezanpour, M., Thomas, N., Prestidge, C. A., Wormald, P. J., & Vreugde, S. (2016). Mind “De GaPP”: in vitro efficacy of deferiprone and gallium-protoporphyrin against Staphylococcus aureus biofilms. International Forum of Allergy and Rhinology, 6(7), 737-743.
Scopus41 WoS37 Europe PMC242016 Ramezanpour, M., Moraitis, S., Smith, J., Wormald, P., & Vreugde, S. (2016). Th17 cytokines disrupt the airway mucosal barrier in chronic rhinosinusitis. Mediators of Inflammation, 2016, 9798206-1-9798206-7.
Scopus63 WoS49 Europe PMC292015 Thomas, N., Dong, D., Richter, K., Ramezanpour, M., Vreugde, S., Thierry, B., . . . Prestidge, C. (2015). Quatsomes for the treatment of Staphylococcus aureus biofilm. Journal of Materials Chemistry B, 3(14), 2770-2777.
Scopus27 WoS23 Europe PMC62014 Ramezanpour, M., da Silva, K. B., & Sanderson, B. J. (2014). The effect of sea anemone (H. magnifica) venom on two human breast cancer lines: death by apoptosis. Cytotechnology, 66(5), 845-852.
Scopus222014 Ramezanpour, M., da Silva, K. B., & Sanderson, B. J. (2014). Venom present in sea anemone (Heteractis magnifica) induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-mediated pathway. Biotechnology Letters, 36(3), 489-495.
Scopus18 Europe PMC62012 Ramezanpour, M., Burke da Silva, K., & Sanderson, B. J. (2012). Differential susceptibilities of human lung, breast and skin cancer cell lines to killing by five sea anemone venoms. Journal of Venomous Animals and Toxins including Tropical Diseases, 18(2), 157-163.
Scopus17- Marine bioactive products as anti-cancer agents: effects of sea anemone venom on breast and lung cancer cells (n.d.). Cancer Cell & Microenvironment.
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Book Chapters
Year Citation 2016 Sanderson, B., Burke Da Silva, K., & Ramezanpour, M. (2016). How Venom from the Magnificent Sea Anemone, Heteractis magnifica, Kills Breast and Lung Cancer Cells. In S. Goffredo, & Z. Dubinsky (Eds.), The Cnidaria, Past, Present and Future The world of Medusa and her sisters (pp. 669-682). Switzerland: Springer.
Scopus1
| Date | Project/ No. | Investigators | Funding Body | Amount |
|---|---|---|---|---|
| 2020 | A personalised therapeutic plan for S. aureus recalcitrant CRS |
Professor Alkis Psaltis Dr Mahnaz Ramezanpour |
The Garnett Passe and Rodney Williams Memorial Foundation | $362,363 |
- Demonstrator: Flinders University, 2011-2014
Undergraduate demonstrating of first-year flinders biological topic
- Tutor: Flinders University, 2012-2014
Tutoring undergraduate students in the medical biochemistry department
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Potential use of essential oils from ethno-medicinal plants in clinical research Doctor of Philosophy Doctorate Full Time Miss Sumeena Karki -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2021 - 2023 Co-Supervisor Investigating Transcription Factors in the Human Airway Mucosal Immunoepigenetics of Chronic Inflammatory Disease Master of Philosophy (Surgery) Master Full Time Mr Harrison Burchill Bolt 2019 - 2022 Co-Supervisor Effects of Pseudomonas aeruginosa exoproteins on nasal mucosal barrier in chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Mrs Jannatul Ferdoush Tuli 2018 - 2020 Co-Supervisor Nasal mucus: friend or foe? The effect of mucus on mucosal barrier dysfunction in chronic rhinosinusitis Doctor of Philosophy Doctorate Full Time Dr Stephen Shih-Teng Kao
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Committee Memberships
Date Role Committee Institution Country 2018 - 2018 Member Women’s and Children’s Hospital (WCH) Foundation Research Grants Committee Women’s and Children’s Hospital (WCH) Australia 2018 - ongoing Member Woodcutters Road Environmental Protection Association Woodcutters Road Environmental Protection Association Australia 2015 - ongoing Member Astronomical Society of Flinders University Astronomical Society of Flinders University Australia
Connect With Me
External Profiles
