Luke Traeger
Adelaide Medical School
Faculty of Health and Medical Sciences
Dr Luke Traeger is a South Australian General Surgical trainee with the Royal Australasian College of Surgeons. Luke is currently undertaking a PhD, researching the effects of novel treatments to reduce bowel paralysis following surgery.
My research investigates the reduction of the incidence and duration of post-operative ileus following colorectal surgery.
After abdominal surgery, the bowel can commonly be paralyzed and slow to return to normal function. The resultant intolerance to food and liquids can result in severe bloating, inability to pass a bowel movement or gas, nausea, and vomiting. This complication of surgery is called post-operative ileus and is a source of discomfort for patients after surgery. Management often requires invasive procedures such as the insertion of long tubes into the stomach to empty it out and providing nutrition through a vein.
With the advent of enhanced recovery protocols, there has been a general improvement in the management of patients undergoing abdominal surgery. However, the incidence of post-operative ileus remains around 20-30%. Post-operative ileus doubles the cost of a patients admission to hospital and significantly increases the patients risk of complication and risk of mortality.
My research will investigate the use of a novel treatment, an acetylcholinesterase inhibitor named pyridostigmine. Pyridostigmine increases gut motility, and we aim to study the effects this has following colorectal surgery. If we can reduce the incidence of post-operative ileus, this may reduce the length of hospital stay and reduce complications in our patients.
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Appointments
Date Position Institution name 2022 - ongoing Clinical Lecturer University of Adelaide -
Education
Date Institution name Country Title 2021 University of Adelaide Australia PhD (Candidate) 2017 - 2018 University of Newcastle Australia Master of Traumatology 2015 - 2016 University of Newcastle Australia Master of Public Health 2009 - 2014 University of Adelaide Australia Bachelor of Medicine, Bachelor of Surgery -
Postgraduate Training
Date Title Institution Country 2019 General Surgical Training Royal Australasian College of Surgeons Australia 2018 - 2018 General Surgical Registrar Queen Elizabeth Hospital Australia 2016 - 2017 Surgical Resident Medical Officer Central Adelaide Local Health Network Australia 2015 - 2015 Internship Central Adelaide Local Health Network Australia -
Research Interests
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Journals
Year Citation 2024 Bedrikovetski, S., Zhang, J., Seow, W., Traeger, L., Moore, J. W., Verjans, J., . . . Sammour, T. (2024). Deep learning to predict lymph node status on pre-operative staging CT in patients with colon cancer. Journal of Medical Imaging and Radiation Oncology, 68(1), 33-40.
Scopus1 Europe PMC12024 Bedrikovetski, S., Traeger, L., Fitzsimmons, T., Price, T. J., Ruszkiewicz, A. R., Vather, R., & Sammour, T. (2024). ASO Visual Abstract: Association Between RAS/BRAF Mutations and Complete Response After Total Neoadjuvant Therapy of Patients with Rectal Cancer: A Prospective Multicentered Study. Annals of surgical oncology, 31(3), 1698-1699.
Scopus2 WoS12024 Traeger, L., Dudi-Venkata, N., Bedrikovetski, S., Kroon, H. M., Moore, J. W., & Sammour, T. (2024). Use of acetylcholinesterase inhibitors in reducing time to gastrointestinal function recovery following abdominal surgery: A systematic review. Digestive Surgery, 41(1), 12-23.
Scopus12024 Bedrikovetski, S., Traeger, L., & Sammour, T. (2024). ASO Author Reflections: Impact of RAS Mutations on Total Neoadjuvant Therapy Outcomes in Rectal Cancer. Annals of Surgical Oncology, 31(3), 1692-1693.
Europe PMC12024 Traeger, L., Bedrikovetski, S., Hanna, J. E., Moore, J. W., & Sammour, T. (2024). Machine learning prediction model for postoperative ileus following colorectal surgery. ANZ Journal of Surgery, 94(7-8), 1292-1298.
2024 Nguyen, T. M., Traeger, L., Overall, B., Sammour, T., & Thomas, M. (2024). Functional outcomes following anterior resection for colorectal cancer: a needs assessment and proposal of a nurse-led remote management algorithm. ANZ Journal of Surgery, 94(9), 1590-1597.
2024 Traeger, L., Bedrikovetski, S., Fitzsimmons, T., Nguyen, T. -M., Moore, J. W., Lewis, M., & Sammour, T. (2024). Pyridostigmine to Reduce the duration of postoperative Ileus after Colorectal surgery (PyRICo-RCT): randomized clinical trial. British Journal of Surgery, 111(5), znae121-1-znae121-9.
2024 Bedrikovetski, S., Traeger, L., Seow, W., Dudi-Venkata, N. N., Selva-Nayagam, S., Penniment, M., & Sammour, T. (2024). Oncological Outcomes and Response Rate After Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: A Network Meta-Analysis Comparing Induction vs. Consolidation Chemotherapy vs. Standard Chemoradiation. Clinical Colorectal Cancer, S1533-0028(24)00056-2.
Scopus12024 Murshed, I., Dinger, T. L., de Gaay Fortman, D. P. E., Traeger, L., Bedrikovetski, S., Hunter, A., . . . Sammour, T. (2024). Outcomes of rectal cancer treatment in rural Australia and New Zealand: analysis of the bowel cancer outcomes registry. ANZ Journal of Surgery, 12 pages.
2024 Traeger, L., Bedrikovetski, S., David, R. V., Jay, A. A., Moore, J. W., & Sammour, T. (2024). Financial implications of sarcopenia in colorectal cancer surgery: a cost analysis in an Australian public hospital. ANZ Journal of Surgery, 9 pages.
2023 Watson, M. M., Watson, D. C., Maddern, G. J., & Wichmann, M. W. (2023). Quality of rural colonoscopy outperforms key performance indicators in a multi‐centre prospective clinical study. ANZ Journal of Surgery, 93(3), 528-533.
Scopus3 WoS12023 Bedrikovetski, S., Traeger, L., Vather, R., Moore, J. W., & Sammour, T. (2023). Clinical and biochemical predictors of tumor response after neoadjuvant therapy in rectal cancer. Asia-Pacific Journal of Clinical Oncology, 19(3), 365-373.
Scopus1 Europe PMC22023 Bedrikovetski, S., Dudi‐Venkata, N. N., Kroon, H. M., Traeger, L. H., Seow, W., Vather, R., . . . Sammour, T. (2023). A prospective study of diagnostic accuracy of multidisciplinary team and radiology reporting of preoperative colorectal cancer local staging. Asia Pacific Journal of Clinical Oncology, 19(1), 206-213.
Scopus1 WoS1 Europe PMC12023 Bedrikovetski, S., Traeger, L., Vather, R., Sammour, T., & Moore, J. W. (2023). Does Sarcopenia Predict Local Response Rates after Chemoradiotherapy for Locally Advanced Rectal Cancer?. Dis Colon Rectum, 66(7), 965-972.
Scopus6 WoS5 Europe PMC32023 Bedrikovetski, S., Traeger, L., Price, T. J., Carruthers, S., Selva-Nayagam, S., Moore, J. W., & Sammour, T. (2023). Can sarcopenia predict complete response after total neoadjuvant therapy in advanced rectal cancer? A multicentre observational cohort study. Journal of Surgical Oncology, 128(1), 75-84.
Scopus9 WoS2 Europe PMC42023 Nguyen, T. M., Traeger, L., Vather, R., Overall, B., Cho, J., & Sammour, T. (2023). Double barrelled uro-colostomy versus Ileal conduit for urinary diversion following pelvic exenteration: a single centre experience. ANZ Journal of Surgery, 93(10), 2450-2456.
Scopus4 WoS1 Europe PMC12023 Bedrikovetski, S., Traeger, L., Jay, A. A., Oehler, M. K., Cho, J., Wagstaff, M., . . . Sammour, T. (2023). Is preoperative sarcopenia associated with postoperative complications after pelvic exenteration surgery?. Langenbeck's archives of surgery, 408(1), 12 pages.
2023 Traeger, L., Bedrikovetski, S., Nguyen, T. M., Kwan, Y. X., Lewis, M., Moore, J. W., & Sammour, T. (2023). The impact of preoperative sarcopenia on postoperative ileus following colorectal cancer surgery.. Techniques in coloproctology, 27(12), 1265-1274.
Scopus7 WoS5 Europe PMC52023 Bedrikovetski, S., Traeger, L., & Sammour, T. (2023). <b>Reply to Letter to the Editor</b>
: Can sarcopenia predict complete response after Total Neoadjuvant Therapy in advanced rectal cancer? A multicentre observational cohort study. Journal of Surgical Oncology, 128(1), 181-182.
Scopus1 Europe PMC12023 Traeger, L., Bedrikovetski, S., Nguyen, T. -M., Moore, J. W., & Sammour, T. (2023). Incidence and associated morbidity of sarcopenia in non-malignant small and large bowel anastomosis: propensity score-matched analysis.. International journal of colorectal disease, 38(1), 9 pages.
Scopus12023 Traeger, L., Koullouros, M., Bedrikovetski, S., Kroon, H. M., Moore, J. W., & Sammour, T. (2023). Global cost of postoperative ileus following abdominal surgery: meta-analysis. BJS Open, 7(3), zrad054-1-zrad054-10.
Scopus11 WoS1 Europe PMC62023 Watson, M. M., Besley, M., Beukes, E., Bhattacharjya, S., Bierton, C., Bruening, M., . . . Maddern, G. J. (2023). Colorectal adenomatous and serrated polyps in rural South Australia: who, why, what and where?. ANZ Journal of Surgery, 93(12), 2939-2945.
2023 Liu, J., Lee, J. Y. T., Bedrikovetski, S., Traeger, L., Moore, J. W., Perry, J. L., . . . Sammour, T. (2023). Clinical predictors of rectal cancer response after neo-adjuvant (Chemo)Radiotherapy in Australia and New Zealand: Analysis of the Bi-National Colorectal Cancer Audit (BCCA). European Journal of Surgical Oncology, 49(11), 107070-1-107070-5.
Scopus1 Europe PMC12022 Traeger, L., Koullouros, M., Bedrikovetski, S., Kroon, H. M., Thomas, M. L., Moore, J. W., & Sammour, T. (2022). Cost of postoperative ileus following colorectal surgery: a cost analysis in the Australian public hospital setting. Colorectal Disease, 24(11), 1416-1426.
Scopus12 WoS4 Europe PMC82022 Traeger, L., Bedrikovetski, S., Oehler, M. K., Cho, J., Wagstaff, M., Harbison, J., . . . Sammour, T. (2022). Short-term outcomes following development of a dedicated pelvic exenteration service in a tertiary centre.. ANZ J Surg, 92(10), 2620-2627.
Scopus5 WoS3 Europe PMC12022 Traeger, L., Hall, T. D., Bedrikovetski, S., Kroon, H. M., Dudi-Venkata, N. N., Moore, J. W., & Sammour, T. (2022). Effect of neuromuscular reversal with neostigmine/glycopyrrolate versus sugammadex on postoperative ileus following colorectal surgery. Techniques in Coloproctology, 27(3), 217-226.
Scopus6 WoS1 Europe PMC12022 Kroon, H., Traeger, L., Fitridge, R., Sammour, T., McVeay, C., Herath, M., . . . GlobalSurg Collaborative. (2022). SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia, 77(1), 28-39.
Scopus84 WoS45 Europe PMC612022 Traeger, L., Kroon, H. M., Bedrikovetski, S., Moore, J. W., & Sammour, T. (2022). The impact of acetylcholinesterase inhibitors on ileus and gut motility following abdominal surgery: a clinical review. ANZ Journal of Surgery, 92(1-2), 69-76.
Scopus8 WoS5 Europe PMC62022 Bedrikovetski, S., Seow, W., Kroon, H. M., Traeger, L., Moore, J. W., & Sammour, T. (2022). Artificial intelligence for body composition and sarcopenia evaluation on computed tomography: A systematic review and meta-analysis. European Journal of Radiology, 149, 110218-1-110218-9.
Scopus18 WoS9 Europe PMC82022 Dinger, T. L., Kroon, H. M., Traeger, L., Bedrikovetski, S., Hunter, A., & Sammour, T. (2022). Regional variance in treatment and outcomes of locally invasive (T4) rectal cancer in Australia and New Zealand: analysis of the Bi-National Colorectal Cancer Audit. ANZ Journal of Surgery, 92(7-8), 1772-1780.
Scopus2 WoS2 Europe PMC12022 Kroon, H. M., Hoogervorst, L. A., Hanna-Rivero, N., Traeger, L., Dudi-Venkata, N. N., Bedrikovetski, S., . . . Sammour, T. (2022). Systematic review and meta-analysis of long-term oncological outcomes of lateral lymph node dissection for metastatic nodes after neoadjuvant chemoradiotherapy in rectal cancer. European Journal of Surgical Oncology, 48(7), 1475-1482.
Scopus15 WoS7 Europe PMC72022 Glasbey, J. C., Abbott, T. E. F., Ademuyiwa, A., Adisa, A., AlAmeer, E., Alshryda, S., . . . Mushawarima, T. (2022). Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. The Lancet, 400(10363), 1607-1617.
Scopus34 WoS24 Europe PMC212022 Bedrikovetski, S., Traeger, L., Fitzsimmons, T., Perry, J., Vather, R., Moore, J. W., & Sammour, T. (2022). Personalized total neoadjuvant therapy versus chemotherapy during the 'wait period' versus standard chemoradiotherapy for locally advanced rectal cancer. ANZ Journal of Surgery, 93(5), 1267-1273.
Scopus3 WoS12021 David, R., Traeger, L., Kahokehr, A., Miller, J., & Ashrafi, A. (2021). A prospective case series of Fournier's gangrene at a tertiary centre involving adjacent organs. ANZ Journal of Surgery, 91(12), 2817-2823.
Scopus1 WoS1 Europe PMC12021 Dudi Venkata, N. N., Kroon, H. M., Bedrikovetski, S., Traeger, L., Lewis, M., Lawrence, M. J., . . . Sammour, T. (2021). PyRICo-Pilot: Pyridostigmine to reduce the duration of postoperative ileus after colorectal surgery - a phase II study. Colorectal Disease, 23(8), 2154-2160.
Scopus11 WoS5 Europe PMC62021 Traeger, L., Kroon, H., & Dudi Venkata, N. (2021). Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia, 76(11), 1454-1464.
WoS23 Europe PMC292021 Traeger, L., & Raju, D. (2021). Metastatic squamous cell carcinoma presenting as an ileocolonic fistula. ANZ Journal of Surgery, 91(1-2), 200-202.
2021 CovidSurge Collaborative., & GlobalSurg Collaborative. (2021). Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. Anaesthesia, 76(6), 748-758.
WoS227 Europe PMC2502021 Traeger, L., Kundu, N., & Kiu, A. (2021). Midgut volvulus imitating acute appendicitis. ANZ Journal of Surgery, 91(4), E247-E248.
WoS1 Europe PMC12021 Kundu, N., Traeger, L., & Kiu, A. (2021). Paraganglioma presenting as acute catecholamine cardiomyopathy. ANZ Journal of Surgery, 91(10), 2209-2211.
2021 CovidSurg Collaborative., Kroon, H., Dudi Venkata, N., Traeger, L., Coventry, B., Sammour, T., & Traeger, L. (2021). SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. British Journal of Surgery, 108(9), 1056-1063.
Scopus90 WoS69 Europe PMC2892019 David, R., Traeger, L., & McDonald, C. (2019). Gall bladder torsion: A disease of the elderly. BMJ Case Reports, 12(10), 3 pages.
Scopus12018 Traeger, L., & Kiroff, G. (2018). Intrabilary obstruction by colorectal metastases. Journal of Surgical Case Reports, 2018(1), 2 pages.
Scopus2 WoS32017 Traeger, L., Jayasuriya, M., Suppiah, A., & Devitt, P. (2017). Acupuncture: a cause of mediastinal abscess presenting as axillary infection. ANZ Journal of Surgery, 87(9), E106-E107.
Scopus2 Europe PMC1 -
Conference Papers
Year Citation 2018 Traeger, L., Kiroff, G., & Myers, J. (2018). Multiple rapid swallows in high-resolution oesophageal manometry: A valuable predictor of oesophagogastric junction function.. In Royal Australasian College of Surgeons Annual Scientific Conference. 2018 Traeger, L., & Bhattacharjya, S. (2018). Evaluation of P-POSSUM use in predicting Mortality and Morbidity of emergency general surgical admissions. In Board in General Surgery Registrar’s Paper Day. Adelaide. -
Conference Items
Year Citation 2021 Traeger, L., & Wichmann, M. (2021). Laparoscopic removal of ingested sewing pin.. Poster session presented at the meeting of Royal Australasian College of Surgeons Annual Scientific Congress. Melbourne. 2021 Kundu, N., Traeger, L., & Kiu, A. (2021). Midgut volvulus imitating acute appendicitis.. Poster session presented at the meeting of Royal Australasian College of Surgeons Annual Scientific Congress. 2021 Traeger, L., Kundu, N., & Kiu, A. (2021). Paraganglioma presenting as acute catecholamine cardiomyopathy.. Poster session presented at the meeting of Royal Australasian College of Surgeons Annual Scientific Congress. 2019 Traeger, L., & Kanhere, H. (2019). Small bowel obstruction from solitary breast metastases.. Poster session presented at the meeting of Royal Australasian College of Surgeons Annual Scientific Conference. Bangkok. 2017 Traeger, L., & Kiroff, G. (2017). Intrabiliary metastases: a rare complication of metastatic colorectal cancer.. Poster session presented at the meeting of Royal Australasian College of Surgeons Annual Scientific Congress. Adelaide. 2017 Traeger, L., Jayasuriya, M., Suppiah, A., & Devitt, P. (2017). Acupuncture: more harm than good.. Poster session presented at the meeting of Royal Australasian College of Surgeons Annual Scientific Congress. Adelaide.
Scholarships
2023: RACS RP Jepson scholarship ($66,000 pa.)
2021-2023: Dawes Top-Up Scholarship, RAH Research Committee ($15,000)
2021-2022: Research and Training Stipend, University of Adelaide ($28,000 pa.)
Grant:
2022-2023: CALHN CEO Clinical Rapid Implementation Project Scheme Grant ($200,000)
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