Adelaide Medical School
Faculty of Health and Medical Sciences
My research focuses on the sensory signalling of the bladder and gastrointestinal tract, and how the aberrant signalling from visceral organs is linked to the symptoms of common disorders such as irritable bowel syndrome (IBS), overactive bladder (OAB) and interstitial cystitis (IC). We currently have a number of projects focussed on the neuronal connections within the peripheral and central nervous systems which maintain normal physiological function between bladder and bowel and how these interactions are essential for the development of comorbidity between abdominal and pelvic pain pathologies.
Our research uses a number of electrophysiology techniques including whole cell patch clamp, calcium imaging, single-cell PCR and ex-vivo single afferent recordings from bladder and colon to further understand the intricate communication of neurons .
Visceral Pain Group, Centre for Nutrition and Gastrointestinal Diseases,
The University of Adelaide, Level 7,
South Australian Health and Medical Research Institute (SAHMRI),
North Terrace, Adelaide, SA 5000, Australia.
Year Citation 2018 Spencer, N., Greenheigh, S., Kyloh, M., Hibberd, T., Sharma, H., Grundy, L. ... Zagorodnyuk, V. (2018). Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice. Journal of Comparative Neurology, 526, 4, 707-720.
2018 Grundy, L., Daly, D. M., Chapple, C., Grundy, D. & Chess-Williams, R. (2018). TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder. SCIENTIFIC REPORTS, 8, 1, -.
2018 Erickson, A., Deiteren, A., Harrington, A. M., Garcia-Caraballo, S., Castro, J., Caldwell, A. ... Brierley, S. M. (2018). Voltage-gated sodium channels: (NaV )igating the field to determine their contribution to visceral nociception.. J Physiol, -.
2017 Inserra, M., Israel, M., Caldwell, A., Castro, J., Deuis, J., Harrington, A. ... Vetter, I. (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7, 42810-1-42810-19.
2017 Grundy, L. & Brierley, S. M. (2017). Cross-organ sensitisation between the colon and bladder: To pee, or not to pee?. American journal of physiology. Gastrointestinal and liver physiology, ajpgi.00272.2017-.
2017 Castro, J., Harrington, A., Garcia-Caraballo, S., Maddern, J., Grundy, L., Zhang, J. ... Brierley, S. (2017). α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut, 66, 6, 1083-1094.
2017 Castro, J., Grundy, L., Deiteren, A., Harrington, A. M., O'Donnell, T., Maddern, J. ... Brierley, S. M. (2017). Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.. British journal of pharmacology, -.
2016 Grundy, L., Garcia-Caraballo, S., Maddern, J., Rychkov, G., Hannig, G., Kurtz, C. ... Brierley, S. (2016). Chronic oral administration of the guanylate cyclase-C agonist linaclotide attenuates colitis induced bladder afferent hyperactivity. NEUROGASTROENTEROLOGY AND MOTILITY, 28, 29-29. 2016 Osteen, J., Herzig, V., Gilchrist, J., Emrick, J., Zhang, C., Wang, X. ... Julius, D. (2016). Selective spider toxins reveal a role for the Naᵥ1.1 channel in mechanical pain. Nature, 534, 7608, 494-499.
2014 Keating, C., Ewart, L., Grundy, L., Valentin, J. & Grundy, D. (2014). Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials. Neurogastroenterology & Motility, 26, 7, 980-989.
2010 Keating, C., Martinez, V., Ewart, L., Gibbons, S., Grundy, L., Valentin, J. -. P. & Grundy, D. (2010). The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions. Toxicology and Applied Pharmacology, 245, 3, 299-309.
Year Citation 2017 Castro, J., Deiteren, A., Harrington, A., Maddern, J., Moore, J., Garcia-Caraballo, S. ... Brierley, S. (2017). Chronic oral administration of linaclotide inhibits nociceptive signalling in response to noxious colorectal distension in a model of chronic visceral hypersensitivity. Digestive Disease Week (DDW) 2017. Chicago, IL.
2014 Mills, K., Grundy, L., Rose'Meyer, R., McDermott, C. & Chess-Williams, R. (2014). Cyclophosphamide and ifosfamide enhancement of bladder sensory nerve activity. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress. Melbourne, Vic..
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