Mr Luke Gierus
Higher Degree by Research Candidate
PhD Candidate
School of Biomedicine
Faculty of Health and Medical Sciences
Luke Gierus is a Doctor of Philosophy student at the University of Adelaide. He is currently supervised by Professor Paul Thomas and Dr. Owain Edwards.
The focus of Luke's research is to develop strategies to facilitate in the humane suppression of invasive rodents through modification of naturally-occurring meiotic drive systems.
Luke's research is centred around developing novel gene drive methods to humanely suppress invasive rodent populations. These strategies utilise CRISPR/Cas9 and the t haplotype system to create a gene drive while investigating control strategies.
Luke also has a keen interest in modifying and improving CRISPR/Cas9 and similar systems including prime editing.
Members of the Genome Editing Laboratory, 2020: Ashleigh Geiger, Dr Gelshan Godahewa, Ya-han Kang, Joshua Chey, Professor Paul Thomas, Michaela Scherer, Jayshen Arudkumar, Dr Chandran Pfitzner, Caleb Lushington, Luke Gierus, Melissa White, Sandra Sandra Piltz, Dr Mark Bunting,
Not pictured: Dr Fatwa Adikusuma, Dr Stefka Tahseva.
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Language Competencies
Language Competency English Can read, write, speak, understand spoken and peer review -
Certifications
Date Title Institution name Country 2017 Faculty of Sciences Outstanding Academic Achievement Award The University of Adelaide - 2016 Faculty of Sciences Outstanding Academic Achievement Award The University of Adelaide - -
Research Interests
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Journals
Year Citation 2024 Bunting, M. D., Godahewa, G. I., McPherson, N. O., Robertson, L. J., Gierus, L., Piltz, S. G., . . . Thomas, P. Q. (2024). Investigating the potential of X chromosome shredding for mouse genetic biocontrol. Scientific Reports, 14(1), 14 pages.
2023 Gierus, L., Birand, A., Bunting, M. D., Godahewa, G. I., Piltz, S. G., Oh, K. P., . . . Thomas, P. Q. (2023). Leveraging a natural murine meiotic drive to suppress invasive populations (vol 119, e2213308119, 2022). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(2), 2 pages.
2022 Gierus, L., Birand, A., Bunting, M., Godahewa, G., Piltz, S., Oh, K., . . . Thomas, P. (2022). Leveraging a natural murine meiotic drive to suppress invasive populations.
2022 Bunting, M. D., Pfitzner, C., Gierus, L., White, M., Piltz, S., & Thomas, P. Q. (2022). Generation of Gene Drive Mice for Invasive Pest Population Suppression.. Methods in molecular biology (Clifton, N.J.), 2495, 203-230.
Scopus6 Europe PMC52022 Gierus, L., Birand, A., Bunting, M. D., Godahewa, G. I., Piltz, S. G., Oh, K. P., . . . Thomas, P. Q. (2022). Leveraging a natural murine meiotic drive to suppress invasive populations. Proceedings of the National Academy of Sciences of USA, 119(46), 1-11.
Scopus17 WoS5 Europe PMC102021 Adikusuma, F., Lushington, C., Arudkumar, J., Godahewa, G. I., Chey, Y. C. J., Gierus, L., . . . Thomas, P. Q. (2021). Optimized nickase- and nuclease-based prime editing in human and mouse cells. Nucleic Acids Research, 49(18), 10785-10795.
Scopus42 WoS26 Europe PMC25 -
Preprint
Year Citation 2024 Chey, Y., Gierus, L., Lushington, C., Arudkumar, J., Geiger, A., Staker, L., . . . Adikusuma, F. (2024). Enhancing gRNA Transcript levels by Reducing the Scaffold Poly-T Tract for Optimal SpCas9- and SaCas9-mediated Gene Editing.
DOI2021 Adikusuma, F., Lushington, C., Arudkumar, J., Godahewa, G., Chey, Y. C. J., Gierus, L., . . . Thomas, P. (2021). Optimized nickase- and nuclease-based prime editing in human and mouse cells.
DOI
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