
Associate Professor Luciano Martelotto
Head, Development Laboratory, ACE
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
A/Professor Luciano Martelotto has recently been appointed Head of the Development Laboratory of the Adelaide Centre for Epigenetics (ACE), South Australia ImmunoGENomics Cancer Institute (SAIGENCI). Prior to joining ACE/SAIGENCI, he was the Scientific Director of the Single Cell Laboratory at Harvard Medical School, Department of Systems Biology, Harvard University (USA). During his role at the Single Cell Lab at HMS he led a team of technology specialist in charge of developing, implementing, and offering methods of single-cell profiling to build a bridge between researchers and single-cell technologies in their quest to understand how cells collectively perform systems-level functions in healthy and diseased states.
He is also a Technology Advisor for multiple companies including Omniscope, Paragon Genomics, Honeycomb Bio, ArgeTAG, Truckee Applied Genomics and South Australian Genomics Centre.
Luciano has a robust interdisciplinary scientific background, specialising in molecular biology and biochemistry with a strong background in technology and engineering. He is originally a cell and molecular biologist with a degree in Biotechnology, a PhD in Biological Sciences and Post-doctoral training in cancer genomics and single cell sequencing technologies. His diverse scientific background stems from working in a wide range of fields – plants genetics, microbiology, cancer biology and genomics – and has shaped my ambition and capacity to learn, create, develop, and apply technologies that cross multiple disciplines. The common thread woven throughout his career path has been the focus on converging ideas from various sciences and taking this ideology to develop or refine approaches to address challenges in real life settings and ultimately contribute to improving lives through technological advancements.
Areas of Expertise
- Single Cell-omics
- Spatial-omics
- Management
- Method Development
- Molecular Biology
- Leadership
- Genome Engineering
- NGS Technologies
- Strategy
- Technology Intelligence
My Research
A/Professor Luciano Martelotto's Single cell and Spatial-omics lab at ACE/SAIGENCI will be a dedicated incubator for the development and early-stage evaluation of new single cell, spatial and genomics tools and methodologies. It will serve as a creative hub for generating new technologies, protocol development, equipment evaluation and informatics tool development/integration. The focus of this lab and team (an Innovation team) will constantly evolve due to the fast-paced advancement of the genomics field, but the focus will remain on developing technologies that have the potential to advance research and its practical application for the wider scientific community. It will be highly collaborative technology-based hub that delivers on sought out technical and intellectual support during all stages of experimentation, such as (but not limited to) planning, design, execution, and interpretation. His lab will work as a one stop shop for collaborators willing to access novel tech, get technical and developmental support, and troubleshooting.
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Appointments
Date Position Institution name 2021 - ongoing Head of the Development Laboratory South Australia ImmunoGENomics Cancer Institute (SAIGENCI) 2020 - ongoing Scientific Director, Single Cell Core Laboratory Harvard University 2018 - 2020 Head of Single Cell Innovation Lab University of Melbourne 2017 - 2019 Subject Matter Expert SOPHiA GENETICS 2016 - 2017 Senior Research Fellow Monash University 2013 - 2016 Research Fellow. Memorial Sloan Kettering Cancer Center 2008 - 2012 Postdoctoral Fellow. Monash University 2006 - 2008 Research Associate La Trobe University -
Awards and Achievements
Date Type Title Institution Name Country Amount 2011 Award MIMR Flagship Program 2011, Award and Grant. 2011 ($50,000) Monash University Australia - 2006 Scholarship Molecular Plant Breeding Cooperative Research Centre PhD scholarship. Molecular Plant Breeding Cooperative Research Centre Argentina - 2006 Award PhD Student Academic Merit Award National University of Rosario Argentina - 2005 Award Best PhD student presentation and the Argentinean Society of Cell and Molecular Biology. 2006 Best PhD Argentinean Society of Biology Argentina - 2005 Award Biennial Best Contribution Award Dr. Francisco A. Sáez Argentina - 2003 Scholarship Cold Spring Harbor Laboratory (CSHL) scholarship Cold Spring Harbor Laboratory (CSHL) United States - 2003 Scholarship Consejo Nacional de Investigaciones Científicas y Técnicas PhD scholarship. Consejo Nacional de Investigaciones Científicas y Técnicas Argentina - 2002 Award Biotechnology Student Academic Merit Award National University of Rosario Argentina - 2002 Award Best Undergraduate Contribution Award Argentinean Society of Biology Argentina - 2002 Award Highest Impact Publication Award. MIMR Monash University Australia - -
Education
Date Institution name Country Title 2006 National University of Rosario Argentina PhD in Biological Sciences and Molecular Biology 2002 National University of Rosario, Institute for Molecular and Cellular Biology of Rosario Argentina Biotechnology Graduate -
Postgraduate Training
Date Title Institution Country 2013 - 2016 Cancer genomics Memorial Sloan Kettering Cancer Center USA 2008 - 2016 Cancer genomics Monash University Australia -
Certifications
Date Title Institution name Country 2006 PhD Universidad Nacional de Rosario Argentina -
Research Interests
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Journals
Year Citation 2023 Zethoven, M., Martelotto, L., Pattison, A., Bowen, B., Balachander, S., Flynn, A., . . . Tothill, R. W. (2023). Author Correction: Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment (Nature Communications, (2022), 13, 1, (6262), 10.1038/s41467-022-34011-3). Nature Communications, 14(1), 123.
2023 Mathiyalagan, P., Martelotto, L. G., Ounzain, S., El-Osta, A., & Uchida, S. (2023). Editorial: RNA-chromatin interactions: Biology, mechanism, disease and therapeutics. Frontiers in Genetics, 13, 1069427.
2023 De Rop, F. V., Hulselmans, G., Flerin, C., Soler-Vila, P., Rafels, A., Christiaens, V., . . . Heyn, H. (2023). Systematic benchmarking of single-cell ATAC-sequencing protocols. Nature Biotechnology.
2023 Tsui, V., Lyu, R., Novakovic, S., Stringer, J. M., Dunleavy, J. E. M., Granger, E., . . . Crismani, W. (2023). <i>Fancm</i> has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals.. Cell genomics, 3(8), 100349.
2022 Law, A. M. K., Chen, J., Colino-Sanguino, Y., Fuente, L. R. D. L., Fang, G., Grimes, S. M., . . . Gallego-Ortega, D. (2022). ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo. Advanced Science, 9(21), 2103332-1-2103332-19.
Europe PMC22022 Safabakhsh, S., Sar, F., Martelotto, L., Haegert, A., Singhera, G., Hanson, P., . . . Laksman, Z. (2022). Isolating Nuclei From Frozen Human Heart Tissue for Single-Nucleus RNA Sequencing. Current Protocols, 2(7), e480.
Scopus22022 Tsui, V., Lyu, R., Novakovic, S., Stringer, J., Dunleavy, J., Granger, E., . . . Crismani, W. (2022). <i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammals.
2022 Fennell, K. A., Vassiliadis, D., Lam, E. Y. N., Martelotto, L. G., Balic, J. J., Hollizeck, S., . . . Dawson, M. A. (2022). Non-genetic determinants of malignant clonal fitness at single-cell resolution. Nature, 601(7891), 125-131.
Scopus42 Europe PMC282022 Gruber, E., So, J., Lewis, A. C., Franich, R., Cole, R., Martelotto, L. G., . . . Kats, L. M. (2022). Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells. Cell Reports, 40(7), 1-24.
Scopus3 Europe PMC22022 Vallejo, A., Harvey, K., Wang, T., Wise, K., Butler, L., Polo, J., . . . Martelotto, L. (2022). snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling.
2022 Novakovic, S., Tsui, V., Semple, T., Martelotto, L., McCarthy, D. J., & Crismani, W. (2022). SSNIP-seq: A simple and rapid method for isolation of single-sperm nucleic acid for highthroughput sequencing. PLoS ONE, 17(9), 1-12.
2022 Zethoven, M., Martelotto, L., Pattison, A., Bowen, B., Balachander, S., Flynn, A., . . . Tothill, R. W. (2022). Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. Nature Communications, 13(1), 6262.
Scopus9 Europe PMC62022 Herring, C. A., Simmons, R. K., Freytag, S., Poppe, D., Moffet, J. J. D., Pflueger, J., . . . Lister, R. (2022). Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution. Cell, 185(23), 4428-4447.e28.
Scopus6 WoS6 Europe PMC62022 Lee, P. W., Marshall, A. C., Knott, G. J., Kobelke, S., Martelotto, L., Cho, E., . . . Fox, A. H. (2022). Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains. Journal of Biological Chemistry, 298(11), 1-15.
2022 Gularte-Mérida, R., Smith, S., Bowman, A. S., da Cruz Paula, A., Chatila, W., Bielski, C. M., . . . Hechtman, J. F. (2022). Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer.. JCO precision oncology, 6(6), e2100365.
2022 Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., . . . Johnstone, R. W. (2022). Epigenetic activation of plasmacytoid DC drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12(6), 1560-1579.
Scopus4 WoS3 Europe PMC22021 Gherardin, N. A., Waldeck, K., Caneborg, A., Martelotto, L. G., Balachander, S., Zethoven, M., . . . Tothill, R. W. (2021). γδ T cells in merkel cell carcinomas have a proinflammatory profile prognostic of patient survival. Cancer Immunology Research, 9(6), 612-623.
Scopus15 Europe PMC132021 Kearney, C. J., Vervoort, S. J., Ramsbottom, K. M., Todorovski, I., Lelliott, E. J., Zethoven, M., . . . Johnstone, R. W. (2021). SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells. Science Advances, 7(8), eabe3610-1-eabe3610-12.
Scopus33 WoS31 Europe PMC232021 Lelliott, E. J., Kong, I. Y., Zethoven, M., Ramsbottom, K. M., Martelotto, L. G., Meyran, D., . . . Vervoort, S. J. (2021). CDK4/6 inhibition promotes antitumor immunity through the induction of T-cell memory. Cancer Discovery, 11(10), 2582-2601.
Scopus38 Europe PMC312021 Wagle, M. V., Vervoort, S. J., Kelly, M. J., Van Der Byl, W., Peters, T. J., Martin, B. P., . . . Parish, I. A. (2021). Antigen-driven EGR2 expression is required for exhausted CD8⁺ T cell stability and maintenance. Nature Communications, 12(1), 1-15.
Scopus11 WoS11 Europe PMC72021 Lelliott, E. J., Mangiola, S., Ramsbottom, K. M., Zethoven, M., Lim, L., Lau, P. K. H., . . . Sheppard, K. E. (2021). Combined BRAF, MEK, and CDK4/6 inhibition depletes intratumoral immune-potentiating myeloid populations in melanoma. Cancer Immunology Research, 9(2), 136-146.
Scopus12 Europe PMC102021 Alidousty, C., Duerbaum, N., Wagener-Ryczek, S., Baar, T., Martelotto, L. G., Heydt, C., . . . Schultheis, A. M. (2021). Prevalence and potential biological role of TERT amplifications in ALK translocated adenocarcinoma of the lung. Histopathology, 78(4), 578-585.
Scopus4 Europe PMC22020 Waylen, L. N., Nim, H. T., Martelotto, L. G., & Ramialison, M. (2020). From whole-mount to single-cell spatial assessment of gene expression in 3D. Communications Biology, 3(1), 1-11.
Scopus60 Europe PMC442020 Liu, X., Ouyang, J. F., Rossello, F. J., Tan, J. P., Davidson, K. C., Valdes, D. S., . . . Polo, J. M. (2020). Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature, 586(7827), 101-[107].
Scopus91 WoS58 Europe PMC672020 Fettke, H., Steen, J. A., Kwan, E. M., Bukczynska, P., Keerthikumar, S., Goode, D., . . . Nguyen-Dumont, T. (2020). Analytical validation of an error-corrected ultra-sensitive ctDNA next-generation sequencing assay. BioTechniques, 69(2), 133-140.
Scopus32020 Salomon, R., Martelotto, L., Valdes-Mora, F., & Gallego-Ortega, D. (2020). Genomic Cytometry and New Modalities for Deep Single-Cell Interrogation. Cytometry Part A, 97(10), 1007-1016.
Scopus1 Europe PMC12020 Fagan-Solis, K. D., Simpson, D. A., Kumar, R. J., Martelotto, L. G., Mose, L. E., Rashid, N. U., . . . Gupta, G. P. (2020). A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. Cell Reports, 30(5), 1385-1399.e7.
Scopus20 Europe PMC172019 Anaparthy, N., Ho, Y. J., Martelotto, L., Hammell, M., & Hicks, J. (2019). Single-cell applications of next-generation sequencing. Cold Spring Harbor Perspectives in Medicine, 9(10), a026898-1-a026898-25.
Scopus13 Europe PMC112019 Bell, C. C., Fennell, K. A., Chan, Y. C., Rambow, F., Yeung, M. M., Vassiliadis, D., . . . Dawson, M. A. (2019). Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nature Communications, 10(1), 2723-1-2723-15.
Scopus95 Europe PMC722019 Verghese, E., Martelotto, L. G., Cain, J. E., Williams, T. M., Wise, A. F., Hill, P. A., . . . Deane, J. A. (2019). Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury. BMC Research Notes, 12(1), 718-1-718-5.
Scopus3 Europe PMC12018 Alidousty, C., Baar, T., Martelotto, L. G., Heydt, C., Wagener, S., Fassunke, J., . . . Schultheis, A. M. (2018). Genetic instability and recurrent MYC amplification in ALK-translocated NSCLC: a central role of TP53 mutations. Journal of Pathology, 246(1), 67-76.
Scopus43 Europe PMC242018 Marini, K. D., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., . . . Neil Watkins, D. (2018). Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Science Translational Medicine, 10(451), eaat3504-1-eaat3504-13.
Scopus27 WoS25 Europe PMC182018 To, S. Q., Kwan, E. M., Fettke, H. C., Mant, A., Docanto, M. M., Martelotto, L., . . . Azad, A. A. (2018). Expression of Androgen Receptor Splice Variant 7 or 9 in Whole Blood Does Not Predict Response to Androgen-Axis–targeting Agents in Metastatic Castration-resistant Prostate Cancer. European Urology, 73(6), 818-821.
Scopus34 Europe PMC162018 Geyer, F. C., Li, A., Papanastasiou, A. D., Smith, A., Selenica, P., Burke, K. A., . . . Reis-Filho, J. S. (2018). Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nature Communications, 9(1), 1-16.
Scopus100 Europe PMC562018 Kim, J., Geyer, F. C., Martelotto, L. G., Ng, C. K. Y., Lim, R. S., Selenica, P., . . . Weigelt, B. (2018). MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB–NFIB fusion gene. Journal of Pathology, 244(2), 143-150.
Scopus57 Europe PMC332017 Weigelt, B., Comino-Méndez, I., De Bruijn, I., Tian, L., Meisel, J. L., García-Murillas, I., . . . Turner, N. C. (2017). Diverse BRCA1 and BRCA2 reversion mutations in circulating cell-free DNA of therapy-resistant breast or ovarian cancer. Clinical Cancer Research, 23(21), 6708-6720.
Scopus167 Europe PMC942017 Piscuoglio, S., Ng, C. K. Y., Geyer, F. C., Burke, K. A., Cowell, C. F., Martelotto, L. G., . . . Reis-Filho, J. S. (2017). Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast. NPJ breast cancer, 3(1), 48-1-48-11.
Scopus51 Europe PMC332017 Mutter, R. W., Riaz, N., Ng, C. K. Y., Delsite, R., Piscuoglio, S., Edelweiss, M., . . . Powell, S. N. (2017). Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer. Journal of Pathology, 242(2), 165-177.
Scopus41 WoS40 Europe PMC332017 Grzelak, C. A., Sigglekow, N. D., Tirnitz-Parker, J. E. E., Hamson, E. J., Warren, A., Maneck, B., . . . McCaughan, G. W. (2017). Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PLoS ONE, 12(2), e0171480-1-e0171480-23.
Scopus8 WoS8 Europe PMC52017 Martelotto, L. G., Baslan, T., Kendall, J., Geyer, F. C., Burke, K. A., Spraggon, L., . . . Reis-Filho, J. S. (2017). Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples. Nature Medicine, 23(3), 376-385.
Scopus95 WoS88 Europe PMC682017 Spraggon, L., Martelotto, L. G., Hmeljak, J., Hitchman, T. D., Wang, J., Wang, L., . . . Ladanyi, M. (2017). Generation of conditional oncogenic chromosomal translocations using CRISPR–Cas9 genomic editing and homology-directed repair. Journal of Pathology, 242(1), 102-112.
Scopus23 WoS22 Europe PMC172017 Panter, S., Mouradov, A., Badenhorst, P., Martelotto, L., Griffith, M., Smith, K. F., & Spangenberg, G. (2017). Re-programming photosynthetic cells of perennial ryegrass (Lolium perenne L) for fructan biosynthesis through transgenic expression of fructan biosynthetic genes under the control of photosynthetic promoters. Agronomy, 7(2), 13 pages.
Scopus9 WoS82017 Xue, Y., Martelotto, L., Baslan, T., Vides, A., Solomon, M., Mai, T. T., . . . Lito, P. (2017). An approach to suppress the evolution of resistance in BRAF V600E-mutant cancer. Nature Medicine, 23(8), 929-937.
Scopus109 WoS104 Europe PMC822016 Chiang, S., Weigelt, B., Wen, H. C., Pareja, F., Raghavendra, A., Martelotto, L. G., . . . Schnitt, S. J. (2016). IDH2 mutations define a unique subtype of breast cancer with altered nuclear polarity. Cancer Research, 76(24), 7118-7129.
Scopus80 WoS69 Europe PMC502016 Fusco, N., Geyer, F. C., De Filippo, M. R., Martelotto, L. G., Ng, C. K. Y., Piscuoglio, S., . . . Weigelt, B. (2016). Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer. Modern Pathology, 29(11), 1292-1305.
Scopus63 WoS50 Europe PMC332016 Piscuoglio, S., Ng, C. K. Y., Murray, M. P., Guerini-Rocco, E., Martelotto, L. G., Geyer, F. C., . . . Reis-Filho, J. S. (2016). The genomic landscape of male breast cancers. Clinical Cancer Research, 22(16), 4045-4056.
Scopus105 WoS90 Europe PMC622016 Piscuoglio, S., Ng, C. K. Y., Murray, M., Burke, K. A., Edelweiss, M., Geyer, F. C., . . . Reis-Filho, J. S. (2016). Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression. Journal of Pathology, 238(4), 508-518.
Scopus93 WoS83 Europe PMC592016 Fusco, N., Colombo, P. E., Martelotto, L. G., De Filippo, M. R., Piscuoglio, S., Ng, C. K. Y., . . . Weigelt, B. (2016). Resolving quandaries: Basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing. Histopathology, 68(2), 262-271.
Scopus17 WoS16 Europe PMC142016 Piscuoglio, S., Fusco, N., Ng, C. K. Y., Martelotto, L. G., da Cruz Paula, A., Katabi, N., . . . Reis-Filho, J. S. (2016). Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland. Histopathology, 68(7), 1055-1062.
Scopus24 WoS18 Europe PMC92016 Schultheis, A. M., Martelotto, L. G., De Filippo, M. R., Piscuglio, S., Ng, C. K. Y., Hussein, Y. R., . . . Weigelt, B. (2016). TP53 mutational spectrum in endometrioid and serous endometrial cancers. International Journal of Gynecological Pathology, 35(4), 289-300.
Scopus72 WoS64 Europe PMC412016 Piscuoglio, S., Burke, K. A., Ng, C. K. Y., Papanastasiou, A. D., Geyer, F. C., Macedo, G. S., . . . Weigelt, B. (2016). Uterine adenosarcomas are mesenchymal neoplasms. Journal of Pathology, 238(3), 381-388.
Scopus73 WoS73 Europe PMC462015 Piscuoglio, S., Murray, M., Fusco, N., Marchiò, C., Loo, F. L., Martelotto, L. G., . . . Reis-Filho, J. S. (2015). MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast. Histopathology, 67(5), 719-729.
Scopus68 WoS58 Europe PMC452015 Guerini-Rocco, E., Hodi, Z., Piscuoglio, S., Ng, C. K. Y., Rakha, E. A., Schultheis, A. M., . . . Reis-Filho, J. S. (2015). The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: An exploratory, hypothesis-generating study. Journal of Pathology, 237(2), 166-178.
Scopus46 WoS39 Europe PMC322015 Martelotto, L. G., De Filippo, M. R., Ng, C. K., Natrajan, R., Fuhrmann, L., Cyrta, J., . . . Weigelt, B. (2015). Genomic landscape of adenoid cystic carcinoma of the breast. Journal of Pathology, 237(2), 179-189.
Scopus117 WoS105 Europe PMC812015 Ng, C. K. Y., Martelotto, L. G., Gauthier, A., Wen, H. C., Piscuoglio, S., Lim, R. S., . . . Reis-Filho, J. S. (2015). Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification. Genome Biology, 16(1), 21 pages.
Scopus102 WoS91 Europe PMC662014 Weinreb, I., Piscuoglio, S., Martelotto, L. G., Waggott, D., Ng, C. K. Y., Perez-Ordonez, B., . . . Reis-Filho, J. S. (2014). Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nature Genetics, 46(11), 1166-1169.
Scopus163 WoS132 Europe PMC1082014 Martelotto, L. G., Ng, C. K. Y., De Filippo, M. R., Zhang, Y., Piscuoglio, S., Lim, R. S., . . . Weigelt, B. (2014). Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations. Genome biology, 15(10), 484.
Scopus98 WoS90 Europe PMC822014 Martelotto, L. G., Ng, C. K. Y., Piscuoglio, S., Weigelt, B., & Reis-Filho, J. S. (2014). Breast cancer intra-tumor heterogeneity. Breast Cancer Research, 16(3), 11 pages.
Scopus234 WoS206 Europe PMC1542014 Grzelak, C. A., Martelotto, L. G., Sigglekow, N. D., Patkunanathan, B., Ajami, K., Calabro, S. R., . . . McCaughan, G. W. (2014). The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury. Journal of Hepatology, 60(1), 143-151.
Scopus67 WoS57 Europe PMC422014 Piscuoglio, S., Ng, C. K. Y., Martelotto, L. G., Eberle, C. A., Cowell, C. F., Natrajan, R., . . . Reis-Filho, J. S. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular Oncology, 8(8), 1588-1602.
Scopus41 WoS30 Europe PMC252013 Zaitseva, M., Holdsworth-Carson, S. J., Waldrip, L., Nevzorova, J., Martelotto, L., Vollenhoven, B. J., & Rogers, P. A. W. (2013). Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids. Reproduction, 146(2), 91-102.
Scopus18 WoS16 Europe PMC152013 Rossello, F. J., Tothill, R. W., Britt, K., Marini, K. D., Falzon, J., Thomas, D. M., . . . Watkins, D. N. (2013). Next-Generation Sequence Analysis of Cancer Xenograft Models. PLoS ONE, 8(9), e74432-1-e74432-12.
Scopus22 WoS21 Europe PMC172013 Deane, J. A., Verghese, E., Martelotto, L. G., Cain, J. E., Galtseva, A., Rosenblum, N. D., . . . Ricardo, S. D. (2013). Visualizing renal primary cilia. Nephrology, 18(3), 161-168.
Scopus11 WoS10 Europe PMC92013 Barakat, B., Yu, L., Lo, C., Vu, D., De Luca, E., Cain, J. E., . . . Hannigan, G. E. (2013). Erratum: Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling (EMBO Reports (2013) 14 ( 679-682) Doi:10.1038/embor.2013.97). EMBO Reports, 14(10), 945.
2013 Barakat, B., Yu, L., Lo, C., Vu, D., De Luca, E., Cain, J. E., . . . Hannigan, G. E. (2013). Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. EMBO Reports, 14(9), 837-844.
Scopus22 WoS23 Europe PMC212011 Marini, K. D., Payne, B. J., Watkins, D. N., & Martelotto, L. G. (2011). Mechanisms of Hedgehog signalling in cancer. Growth Factors, 29(6), 221-234.
Scopus48 WoS42 Europe PMC332011 Park, K. S., Martelotto, L. G., Peifer, M., Sos, M. L., Karnezis, A. N., Mahjoub, M. R., . . . Sage, J. (2011). A crucial requirement for Hedgehog signaling in small cell lung cancer. Nature Medicine, 17(11), 1504-1508.
Scopus206 WoS190 Europe PMC1562011 O'Toole, S. A., Machalek, D. A., Shearer, R. F., Millar, E. K. A., Nair, R., Schofield, P., . . . Swarbrick, A. (2011). Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Research, 71(11), 4002-4014.
Scopus128 WoS124 Europe PMC1062009 SPANGENBERG GERMAN., MOURADOV AIDYN., GRIFFITH MEGAN ELIZABETH., & MARTELOTTO LUCIANO GASTON. (2009). MODIFICATION OF FRUCTAN BIOSYNTHESIS, INCREASING PLANT BIOMASS, AND ENHANCING PRODUCTIVITY OF BIOCHEMICAL PATHWAYS IN A PLANT. 2009 SPANGENBERG GERMAN., MOURADOV AIDYN., GRIFFITH MEGAN ELIZABETH., & MARTELOTTO LUCIANO GASTON. (2009). Modification of Fructan Biosynthesis, Increasing Plant Biomass, and Enhancing Productivitiy of Biochemical Pathways in a Plant. 2009 SPANGENBERG GERMAN., MOURADOV AIDYN., GRIFFITH MEGAN ELIZABETH., & MARTELOTTO LUCIANO GASTON. (2009). MODIFICATION OF FRUCTAN BIOSYNTHESIS, INCREASING PLANT BIOMASS, AND ENHANCING PRODUCTIVITY OF BIOCHEMICAL PATHWAYS IN A PLANT. 2008 Laspina, N. V., Vega, T., Seijo, J. G., González, A. M., Martelotto, L. G., Stein, J., . . . Pessino, S. C. (2008). Gene expression analysis at the onset of aposporous apomixis in Paspalum notatum. Plant Molecular Biology, 67(6), 615-628.
Scopus49 WoS49 Europe PMC402008 Cervigni, G. D. L., Paniego, N., Díaz, M., Selva, J. P., Zappacosta, D., Zanazzi, D., . . . Echenique, V. (2008). Expressed sequence tag analysis and development of gene associated markers in a near-isogenic plant system of Eragrostis curvula. Plant Molecular Biology, 67(1-2), 1-10.
Scopus33 WoS45 Europe PMC202007 Martelotto, L. G., Ortiz, J. P. A., Stein, J., Espinoza, F., Quarin, C. L., & Pessino, S. C. (2007). Genome rearrangements derived from autopolyploidization in Paspalum sp.. Plant Science, 172(5), 970-977.
Scopus48 WoS43 Europe PMC182007 Mecchia, M. A., Ochogavía, A., Pablo Selva, J., Laspina, N., Felitti, S., Martelotto, L. G., . . . Pessino, S. C. (2007). Genome polymorphisms and gene differential expression in a 'back-and-forth' ploidy-altered series of weeping lovegrass (Eragrostis curvula). Journal of Plant Physiology, 164(8), 1051-1061.
Scopus25 WoS24 Europe PMC132005 Martelotto, L. G., Ortiz, J. P. A., Stein, J., Espinoza, F., Quarin, C. L., & Pessino, S. C. (2005). A comprehensive analysis of gene expression alterations in a newly synthesized Paspalum notatum autotetraploid. Plant Science, 169(1), 211-220.
Scopus44 WoS41 Europe PMC242003 Arabolaza, A. L., Nakamura, A., Pedrido, M. E., Martelotto, L., Orsaria, L., & Grau, R. R. (2003). Characterization of a novel inhibitory feedback of the anti-anti-sigma SpoIIAA on SpoOA activation during development in Bacillus subtilis. Molecular Microbiology, 47(5), 1251-1263.
Scopus26 WoS24 Europe PMC242000 Martnez, M. L., Martelotto, L., & Cabada, M. O. (2000). Purification and biological characterization of N-acetyl β-D glucosaminidase from Bufo arenarum spermatozoa. Molecular Reproduction and Development, 57(2), 194-203.
Scopus34 WoS31 Europe PMC23- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 or Salty-Ez50 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v5.
- G Martelotto, L. (n.d.). snATAC-Seq on 10x ChromiumTM platform for fresh, frozen and cryopreserved material: my notes from the lab (UPDATED VERSION) v1.
- G Martelotto, L. (n.d.). snATAC-Seq on 10x ChromiumTM platform for fresh, frozen and cryopreserved material: my notes from the lab v1.
- Jiménes-Garcia, L. (n.d.). FixNCut v1.0 v1.
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Books
Year Citation 2005 Molecular breeding for the genetic improvement of forage crops and turf (2005). . Brill | Wageningen Academic.
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Book Chapters
Year Citation 2018 Chiang, S., Martelotto, L. G., & Weigelt, B. (2018). Genomic Applications in Gynecologic Malignancies. In Genomic Applications in Pathology: Second Edition 2019 (pp. 445-469). Springer International Publishing.
2015 Chiang, S., Martelotto, L. G., & Weigelt, B. (2015). Genomic Applications in Gynecologic Malignancies. In Genomic Applications in Pathology (pp. 465-487). Springer New York.
2005 Echenique, V., Felitti, S., Paniego, N., Martelotto, L., Pessino, S., Zanazzi, D., . . . Spangenberg, G. C. (2005). Discovery and functional categorisation of expressed sequence tags from flowers of Eragrostis curvula genotypes showing different ploidy levels and reproductive modes. In Molecular Breeding for The Genetic Improvement of Forage Crops and Turf: Proceedings of the 4th International Symposium on The Molecular Breeding of Forage and Turf, a Satellite Workshop of the XXth International Grassland Congress, July 2005, Aberystwyth, Wales (pp. 177).
2005 Martelotto, L. G., Ortiz, J. P. A., Espinoza, F., Quarin, C. L., & Pessino, S. C. (2005). A comprehensive analysis of gene expression and genomic alterations in a newly formed autotetraploid of Paspalum notatum. In Molecular Breeding for The Genetic Improvement of Forage Crops and Turf: Proceedings of the 4th International Symposium on The Molecular Breeding of Forage and Turf, a Satellite Workshop of the XXth International Grassland Congress, July 2005, Aberystwyth, Wales (pp. 178).
Scopus1 -
Conference Papers
Year Citation 2022 Pita-Juarez, Y., Martelotto, L., Kalavros, N., Ploumakis, A., Badlani, D., Huang, P., . . . Vlachos, I. (2022). SPATIAL TRANSCRIPTOMICS REVEALS EXTENSIVE CELLULAR RESTRUCTURING AND THE TRANSCRIPTIONAL LANDSCAPE IN PRIMARY SCLEROSING CHOLANGITIS. In HEPATOLOGY Vol. 76 (pp. S197-S198). WILEY. 2015 Piscuoglio, S., Weinreb, I., Martelotto, L., Ng, C., Fusco, N., Rubin, B., . . . Reis-Filho, J. (2015). PRKD Gene Family Somatic Alterations in Polymorphous Low-Grade Adenocarcinomas of the Salivary Glands. In LABORATORY INVESTIGATION Vol. 95 (pp. 328A). Boston, MA: NATURE PUBLISHING GROUP. 2015 Piscuoglio, S., Paula, A. D. C., Smolders, Y., Fusco, N., Martelotto, L., De Mattos-Arruda, L., . . . Weigelt, B. (2015). EWS16T Is a Useful Marker for the Detection of Microsatellite Instability in Endometrial Cancer. In LABORATORY INVESTIGATION Vol. 95 (pp. 302A). Boston, MA: NATURE PUBLISHING GROUP. 2015 Fusco, N., Martelotto, L., Ng, C., Fuhrtnann, L., Cyrta, J., Guerini-Rocco, E., . . . Weigelt, B. (2015). Genetic Events in the Progression of Adenoid Cystic Carcinomas of the Breast To High-Grade Triple-Negative Breast Cancers. In LABORATORY INVESTIGATION Vol. 95 (pp. 45A). Boston, MA: NATURE PUBLISHING GROUP. 2014 Piscuoglio, S., Ng, C. K., Martelotto, L. G., Eberle, C., Cowell, C. F., Natrajan, R., . . . Reis-Filho, J. S. (2014). Papillary Carcinomas of the Breast Have Distinctive Transcriptomic Profiles and Are Not Underpinned by a Highly Recurrent Fusion Gene. In MODERN PATHOLOGY Vol. 27 (pp. 75A-76A). San Diego, CA: NATURE PUBLISHING GROUP. 2014 Martelotto, L. G., Ng, C. K., Lim, R., Piscuoglio, S., Natrajan, R., Wetterskog, D., . . . Weigelt, B. (2014). The Genomic Landscape of Adenoid Cystic Carcinoma of the Breast. In LABORATORY INVESTIGATION Vol. 94 (pp. 465A). San Diego, CA: NATURE PUBLISHING GROUP. 2014 Piscuoglio, S., Wen, Y. H., Martelotto, L. G., Rocco, E. G., Akram, M., Jungbluth, A. A., . . . Reis-Filho, J. S. (2014). GATA3 Is a Marker of Estrogen Receptor-Positive but Not Estrogen Receptor-Negative Breast Cancers. In LABORATORY INVESTIGATION Vol. 94 (pp. 76A). San Diego, CA: NATURE PUBLISHING GROUP. 2014 Marini, K. D., Rossello, F. J., Martelotto, L. G., & Watkins, D. N. (2014). Using synthetic lethal screening to identify therapeutic targets for innately platinum resistant lung cancer. In CANCER RESEARCH Vol. 74 (pp. 1 page). San Diego, CA: AMER ASSOC CANCER RESEARCH.
2013 Marini, K., Tothill, R., Britt, K., Falzon, J., Li, J., Bennett, S., . . . Rossello, F. (2013). DETERMINING READ ORIGIN OF NEXT-GENERATION SEQUENCING DATASETS FROM LUNG CANCER XENOGRAFTS. In JOURNAL OF THORACIC ONCOLOGY Vol. 8 (pp. S763). LIPPINCOTT WILLIAMS & WILKINS. 2013 Marini, K., Rossello, F., Martelotto, L., & Watkins, N. (2013). USING SYNTHETIC LETHAL SCREENING TO IDENTIFY THERAPEUTIC TARGETS FOR INNATELY PLATINUM RESISTANT LUNG CANCER. In JOURNAL OF THORACIC ONCOLOGY Vol. 8 (pp. S352). LIPPINCOTT WILLIAMS & WILKINS.
WoS12011 Grzelak, C. A., Martelotto, L. G., Warner, F. J., Sigglekow, N. D., Patkunanathan, B., Watkins, D. N., . . . Mccaughan, G. W. (2011). The hedgehog pathway in hepatocellular liver injury progression. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 26 (pp. 13-14). WILEY-BLACKWELL.
WoS12011 Martelotto, L., Falzon, J., Bennett, S., Brown, T., & Watkins, N. (2011). AN IN-VIVO MODEL OF ACQUIRED CHEMORESISTANCE IN SMALL CELL LUNG CANCER. In JOURNAL OF THORACIC ONCOLOGY Vol. 6 (pp. S26). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC. 2009 Peacock, C., Martelotto, L., Travaglione, V., McGovern, K., Read, M., Berman, D., . . . Watkins, D. (2009). Visualization of SMOOTHENED activation supports an essential role for Hedgehog signaling in the regulation of self-renewal in small cell lung cancer. In CANCER RESEARCH Vol. 69 (pp. 1 page). AMER ASSOC CANCER RESEARCH. -
Datasets
Year Citation - G Martelotto, L. (n.d.). &#39;Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x Genomics Platform) v1.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v4.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v3.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for parallel snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation (UPDATED version) v5.
- G Martelotto, L. (n.d.). Daughter of Frankenstein protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® continuous gradient v2.
- G Martelotto, L. (n.d.). &#39;Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x Genomics Platform) v2.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v2.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v1.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation v2.
- G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v1.
- G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v2.
- G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v2 v1.
- G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v3.
- G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from fresh and frozen tissue for snRNAseq v1.
- G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v1.
- G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v4.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation v1.
- G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v1.
- G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from fresh and frozen tissue for snRNAseq v2.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for parallel snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation (UPDATED version) v4.
- G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v1.
- G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x genomics Platform) v1.
- G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from fresh and frozen tissue for snRNAseq v3.
- G Martelotto, L. (n.d.). Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x Genomics Platform) v1.
- G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation v3.
- G Martelotto, L. (n.d.). Daughter of Frankenstein protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® continuous gradient v1.
Grants and Funding
GRANTS |
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Dissecting the mutational landscapes and cellular ecosystems of pancreatic cancer. NHMRC Grant APP1160855. Grant Amount: $854,384. Role: CIC. 2019 |
Resolving eosinophil and inflammatory heterogeneity in chronic allergic airway disease for safer, effective and lasting precision therapies. NHMRC Ideas Grant 2004288. Role: CIC. 2021 |
The PRECISE assay. Personalized medicine for cancer patients using next-generation sequencing. Monash Partners Consortium Research Grant 2016. Role: Investigator. Grant amount: AU$116,000. Duration: 2017-2018 |
IN-KIND SUPPORT |
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Development of cutting-edge cancer genomics assays for solid and blood tumors
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The PRECISE assay. Personalized medicine for cancer patients using next-generation sequencing.
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Teaching Appointments
July 2020-present | Chan Harvard Bioinformatics Single Cell Genomics Course. Harvard Medical School. | |
Oct 2013 – March 2015 |
New York Academy of Sciences mentor for underrepresented children. Afterschool STEM mentoring program. |
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May 2000 – Oct 2004 Practical. | Practical Tutor, General Biology. National University of Rosario (Argentina). | |
Jan 2002 – Oct 2004 | Tutor, Special Biology. National University of Rosario (Argentina). |
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Somatic cell reprogramming of fibroblasts from different mammals to model early development. Doctor of Philosophy Doctorate Full Time Miss Elly Deidre Walters 2023 Co-Supervisor How pluripotent transcription factors reshape the prostate cancer epigenetic landscape to reprogram the cell fate toward neuroendocrine-like with their cofactors Doctor of Philosophy Doctorate Full Time Mr Tianjun Zhang
Connect With Me
External Profiles