Luciano Martelotto

Associate Professor Luciano Martelotto

Head, Development Laboratory, ACE

South Australian Immunogenomics Cancer Institute

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

A/Professor Luciano Martelotto has recently been appointed Head of the Development Laboratory of the Adelaide Centre for Epigenetics (ACE), South Australia ImmunoGENomics Cancer Institute (SAIGENCI). Prior to joining ACE/SAIGENCI, he was the Scientific Director of the Single Cell Laboratory at Harvard Medical School, Department of Systems Biology, Harvard University (USA). During his role at the Single Cell Lab at HMS he led a team of technology specialist in charge of developing, implementing, and offering methods of single-cell profiling to build a bridge between researchers and single-cell technologies in their quest to understand how cells collectively perform systems-level functions in healthy and diseased states.

He is also a Technology Advisor for multiple companies including Omniscope, Paragon Genomics, Honeycomb Bio, ArgeTAG, Truckee Applied Genomics and South Australian Genomics Centre.

Luciano has a robust interdisciplinary scientific background, specialising in molecular biology and biochemistry with a strong background in technology and engineering. He is originally a cell and molecular biologist with a degree in Biotechnology, a PhD in Biological Sciences and Post-doctoral training in cancer genomics and single cell sequencing technologies. His diverse scientific background stems from working in a wide range of fields – plants genetics, microbiology, cancer biology and genomics – and has shaped my ambition and capacity to learn, create, develop, and apply technologies that cross multiple disciplines. The common thread woven throughout his career path has been the focus on converging ideas from various sciences and taking this ideology to develop or refine approaches to address challenges in real life settings and ultimately contribute to improving lives through technological advancements.

Areas of Expertise
  • Single Cell-omics
  • Spatial-omics
  • Management
  • Method Development
  • Molecular Biology
  • Leadership
  • Genome Engineering
  • NGS Technologies
  • Strategy
  • Technology Intelligence
 
My Research

A/Professor Luciano Martelotto's Single cell and Spatial-omics lab at ACE/SAIGENCI will be a dedicated incubator for the development and early-stage evaluation of new single cell, spatial and genomics tools and methodologies. It will serve as a creative hub for generating new technologies, protocol development, equipment evaluation and informatics tool development/integration. The focus of this lab and team (an Innovation team) will constantly evolve due to the fast-paced advancement of the genomics field, but the focus will remain on developing technologies that have the potential to advance research and its practical application for the wider scientific community. It will be highly collaborative technology-based hub that delivers on sought out technical and intellectual support during all stages of experimentation, such as (but not limited to) planning, design, execution, and interpretation. His lab will work as a one stop shop for collaborators willing to access novel tech, get technical and developmental support, and troubleshooting.

  • Appointments
    Date Position Institution name
    2021 - ongoing Head of the Development Laboratory South Australia ImmunoGENomics Cancer Institute (SAIGENCI)
    2020 - ongoing Scientific Director, Single Cell Core Laboratory Harvard University
    2018 - 2020 Head of Single Cell Innovation Lab University of Melbourne
    2017 - 2019 Subject Matter Expert SOPHiA GENETICS
    2016 - 2017 Senior Research Fellow Monash University
    2013 - 2016 Research Fellow. Memorial Sloan Kettering Cancer Center
    2008 - 2012 Postdoctoral Fellow. Monash University
    2006 - 2008 Research Associate La Trobe University

  • Awards and Achievements
    Date Type Title Institution Name Country Amount
    2011 Award MIMR Flagship Program 2011, Award and Grant. 2011 ($50,000) Monash University Australia -
    2006 Scholarship Molecular Plant Breeding Cooperative Research Centre PhD scholarship. Molecular Plant Breeding Cooperative Research Centre Argentina -
    2006 Award PhD Student Academic Merit Award National University of Rosario Argentina -
    2005 Award Best PhD student presentation and the Argentinean Society of Cell and Molecular Biology. 2006 Best PhD Argentinean Society of Biology Argentina -
    2005 Award Biennial Best Contribution Award Dr. Francisco A. Sáez Argentina -
    2003 Scholarship Cold Spring Harbor Laboratory (CSHL) scholarship Cold Spring Harbor Laboratory (CSHL) United States -
    2003 Scholarship Consejo Nacional de Investigaciones Científicas y Técnicas PhD scholarship. Consejo Nacional de Investigaciones Científicas y Técnicas Argentina -
    2002 Award Biotechnology Student Academic Merit Award National University of Rosario Argentina -
    2002 Award Best Undergraduate Contribution Award Argentinean Society of Biology Argentina -
    2002 Award Highest Impact Publication Award. MIMR Monash University Australia -

  • Education
    Date Institution name Country Title
    2006 National University of Rosario Argentina PhD in Biological Sciences and Molecular Biology
    2002 National University of Rosario, Institute for Molecular and Cellular Biology of Rosario Argentina Biotechnology Graduate

  • Postgraduate Training
    Date Title Institution Country
    2013 - 2016 Cancer genomics Memorial Sloan Kettering Cancer Center USA
    2008 - 2016 Cancer genomics Monash University Australia

  • Certifications
    Date Title Institution name Country
    2006 PhD Universidad Nacional de Rosario Argentina

  • Research Interests
    Cancer Cell Biology Cancer Genetics Cancer Therapy Developmental Biology Developmental Genetics Cancer Biology and Clinical Oncology

  • Journals
    Year Citation
    2023 Zethoven, M., Martelotto, L., Pattison, A., Bowen, B., Balachander, S., Flynn, A., . . . Tothill, R. W. (2023). Author Correction: Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment (Nature Communications, (2022), 13, 1, (6262), 10.1038/s41467-022-34011-3). Nature Communications, 14(1), 123.
    DOI
    2023 Mathiyalagan, P., Martelotto, L. G., Ounzain, S., El-Osta, A., & Uchida, S. (2023). Editorial: RNA-chromatin interactions: Biology, mechanism, disease and therapeutics. Frontiers in Genetics, 13, 1069427.
    DOI
    2023 De Rop, F. V., Hulselmans, G., Flerin, C., Soler-Vila, P., Rafels, A., Christiaens, V., . . . Heyn, H. (2023). Systematic benchmarking of single-cell ATAC-sequencing protocols. Nature Biotechnology.
    DOI
    2023 Tsui, V., Lyu, R., Novakovic, S., Stringer, J. M., Dunleavy, J. E. M., Granger, E., . . . Crismani, W. (2023). <i>Fancm</i> has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals.. Cell genomics, 3(8), 100349.
    DOI
    2022 Law, A. M. K., Chen, J., Colino-Sanguino, Y., Fuente, L. R. D. L., Fang, G., Grimes, S. M., . . . Gallego-Ortega, D. (2022). ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo. Advanced Science, 9(21), 2103332-1-2103332-19.
    DOI Europe PMC2
    2022 Safabakhsh, S., Sar, F., Martelotto, L., Haegert, A., Singhera, G., Hanson, P., . . . Laksman, Z. (2022). Isolating Nuclei From Frozen Human Heart Tissue for Single-Nucleus RNA Sequencing. Current Protocols, 2(7), e480.
    DOI Scopus2
    2022 Tsui, V., Lyu, R., Novakovic, S., Stringer, J., Dunleavy, J., Granger, E., . . . Crismani, W. (2022). <i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammals.
    DOI
    2022 Fennell, K. A., Vassiliadis, D., Lam, E. Y. N., Martelotto, L. G., Balic, J. J., Hollizeck, S., . . . Dawson, M. A. (2022). Non-genetic determinants of malignant clonal fitness at single-cell resolution. Nature, 601(7891), 125-131.
    DOI Scopus42 Europe PMC28
    2022 Gruber, E., So, J., Lewis, A. C., Franich, R., Cole, R., Martelotto, L. G., . . . Kats, L. M. (2022). Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells. Cell Reports, 40(7), 1-24.
    DOI Scopus3 Europe PMC2
    2022 Vallejo, A., Harvey, K., Wang, T., Wise, K., Butler, L., Polo, J., . . . Martelotto, L. (2022). snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling.
    DOI
    2022 Novakovic, S., Tsui, V., Semple, T., Martelotto, L., McCarthy, D. J., & Crismani, W. (2022). SSNIP-seq: A simple and rapid method for isolation of single-sperm nucleic acid for highthroughput sequencing. PLoS ONE, 17(9), 1-12.
    DOI
    2022 Zethoven, M., Martelotto, L., Pattison, A., Bowen, B., Balachander, S., Flynn, A., . . . Tothill, R. W. (2022). Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. Nature Communications, 13(1), 6262.
    DOI Scopus9 Europe PMC6
    2022 Herring, C. A., Simmons, R. K., Freytag, S., Poppe, D., Moffet, J. J. D., Pflueger, J., . . . Lister, R. (2022). Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution. Cell, 185(23), 4428-4447.e28.
    DOI Scopus6 WoS6 Europe PMC6
    2022 Lee, P. W., Marshall, A. C., Knott, G. J., Kobelke, S., Martelotto, L., Cho, E., . . . Fox, A. H. (2022). Paraspeckle subnuclear bodies depend on dynamic heterodimerisation of DBHS RNA-binding proteins via their structured domains. Journal of Biological Chemistry, 298(11), 1-15.
    DOI
    2022 Gularte-Mérida, R., Smith, S., Bowman, A. S., da Cruz Paula, A., Chatila, W., Bielski, C. M., . . . Hechtman, J. F. (2022). Same-Cell Co-Occurrence of RAS Hotspot and BRAF V600E Mutations in Treatment-Naive Colorectal Cancer.. JCO precision oncology, 6(6), e2100365.
    DOI
    2022 Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., . . . Johnstone, R. W. (2022). Epigenetic activation of plasmacytoid DC drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12(6), 1560-1579.
    DOI Scopus4 WoS3 Europe PMC2
    2021 Gherardin, N. A., Waldeck, K., Caneborg, A., Martelotto, L. G., Balachander, S., Zethoven, M., . . . Tothill, R. W. (2021). γδ T cells in merkel cell carcinomas have a proinflammatory profile prognostic of patient survival. Cancer Immunology Research, 9(6), 612-623.
    DOI Scopus15 Europe PMC13
    2021 Kearney, C. J., Vervoort, S. J., Ramsbottom, K. M., Todorovski, I., Lelliott, E. J., Zethoven, M., . . . Johnstone, R. W. (2021). SUGAR-seq enables simultaneous detection of glycans, epitopes, and the transcriptome in single cells. Science Advances, 7(8), eabe3610-1-eabe3610-12.
    DOI Scopus33 WoS31 Europe PMC23
    2021 Lelliott, E. J., Kong, I. Y., Zethoven, M., Ramsbottom, K. M., Martelotto, L. G., Meyran, D., . . . Vervoort, S. J. (2021). CDK4/6 inhibition promotes antitumor immunity through the induction of T-cell memory. Cancer Discovery, 11(10), 2582-2601.
    DOI Scopus38 Europe PMC31
    2021 Wagle, M. V., Vervoort, S. J., Kelly, M. J., Van Der Byl, W., Peters, T. J., Martin, B. P., . . . Parish, I. A. (2021). Antigen-driven EGR2 expression is required for exhausted CD8⁺ T cell stability and maintenance. Nature Communications, 12(1), 1-15.
    DOI Scopus11 WoS11 Europe PMC7
    2021 Lelliott, E. J., Mangiola, S., Ramsbottom, K. M., Zethoven, M., Lim, L., Lau, P. K. H., . . . Sheppard, K. E. (2021). Combined BRAF, MEK, and CDK4/6 inhibition depletes intratumoral immune-potentiating myeloid populations in melanoma. Cancer Immunology Research, 9(2), 136-146.
    DOI Scopus12 Europe PMC10
    2021 Alidousty, C., Duerbaum, N., Wagener-Ryczek, S., Baar, T., Martelotto, L. G., Heydt, C., . . . Schultheis, A. M. (2021). Prevalence and potential biological role of TERT amplifications in ALK translocated adenocarcinoma of the lung. Histopathology, 78(4), 578-585.
    DOI Scopus4 Europe PMC2
    2020 Waylen, L. N., Nim, H. T., Martelotto, L. G., & Ramialison, M. (2020). From whole-mount to single-cell spatial assessment of gene expression in 3D. Communications Biology, 3(1), 1-11.
    DOI Scopus60 Europe PMC44
    2020 Liu, X., Ouyang, J. F., Rossello, F. J., Tan, J. P., Davidson, K. C., Valdes, D. S., . . . Polo, J. M. (2020). Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature, 586(7827), 101-[107].
    DOI Scopus91 WoS58 Europe PMC67
    2020 Fettke, H., Steen, J. A., Kwan, E. M., Bukczynska, P., Keerthikumar, S., Goode, D., . . . Nguyen-Dumont, T. (2020). Analytical validation of an error-corrected ultra-sensitive ctDNA next-generation sequencing assay. BioTechniques, 69(2), 133-140.
    DOI Scopus3
    2020 Salomon, R., Martelotto, L., Valdes-Mora, F., & Gallego-Ortega, D. (2020). Genomic Cytometry and New Modalities for Deep Single-Cell Interrogation. Cytometry Part A, 97(10), 1007-1016.
    DOI Scopus1 Europe PMC1
    2020 Fagan-Solis, K. D., Simpson, D. A., Kumar, R. J., Martelotto, L. G., Mose, L. E., Rashid, N. U., . . . Gupta, G. P. (2020). A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. Cell Reports, 30(5), 1385-1399.e7.
    DOI Scopus20 Europe PMC17
    2019 Anaparthy, N., Ho, Y. J., Martelotto, L., Hammell, M., & Hicks, J. (2019). Single-cell applications of next-generation sequencing. Cold Spring Harbor Perspectives in Medicine, 9(10), a026898-1-a026898-25.
    DOI Scopus13 Europe PMC11
    2019 Bell, C. C., Fennell, K. A., Chan, Y. C., Rambow, F., Yeung, M. M., Vassiliadis, D., . . . Dawson, M. A. (2019). Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nature Communications, 10(1), 2723-1-2723-15.
    DOI Scopus95 Europe PMC72
    2019 Verghese, E., Martelotto, L. G., Cain, J. E., Williams, T. M., Wise, A. F., Hill, P. A., . . . Deane, J. A. (2019). Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury. BMC Research Notes, 12(1), 718-1-718-5.
    DOI Scopus3 Europe PMC1
    2018 Alidousty, C., Baar, T., Martelotto, L. G., Heydt, C., Wagener, S., Fassunke, J., . . . Schultheis, A. M. (2018). Genetic instability and recurrent MYC amplification in ALK-translocated NSCLC: a central role of TP53 mutations. Journal of Pathology, 246(1), 67-76.
    DOI Scopus43 Europe PMC24
    2018 Marini, K. D., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., . . . Neil Watkins, D. (2018). Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Science Translational Medicine, 10(451), eaat3504-1-eaat3504-13.
    DOI Scopus27 WoS25 Europe PMC18
    2018 To, S. Q., Kwan, E. M., Fettke, H. C., Mant, A., Docanto, M. M., Martelotto, L., . . . Azad, A. A. (2018). Expression of Androgen Receptor Splice Variant 7 or 9 in Whole Blood Does Not Predict Response to Androgen-Axis–targeting Agents in Metastatic Castration-resistant Prostate Cancer. European Urology, 73(6), 818-821.
    DOI Scopus34 Europe PMC16
    2018 Geyer, F. C., Li, A., Papanastasiou, A. D., Smith, A., Selenica, P., Burke, K. A., . . . Reis-Filho, J. S. (2018). Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nature Communications, 9(1), 1-16.
    DOI Scopus100 Europe PMC56
    2018 Kim, J., Geyer, F. C., Martelotto, L. G., Ng, C. K. Y., Lim, R. S., Selenica, P., . . . Weigelt, B. (2018). MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB–NFIB fusion gene. Journal of Pathology, 244(2), 143-150.
    DOI Scopus57 Europe PMC33
    2017 Weigelt, B., Comino-Méndez, I., De Bruijn, I., Tian, L., Meisel, J. L., García-Murillas, I., . . . Turner, N. C. (2017). Diverse BRCA1 and BRCA2 reversion mutations in circulating cell-free DNA of therapy-resistant breast or ovarian cancer. Clinical Cancer Research, 23(21), 6708-6720.
    DOI Scopus167 Europe PMC94
    2017 Piscuoglio, S., Ng, C. K. Y., Geyer, F. C., Burke, K. A., Cowell, C. F., Martelotto, L. G., . . . Reis-Filho, J. S. (2017). Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast. NPJ breast cancer, 3(1), 48-1-48-11.
    DOI Scopus51 Europe PMC33
    2017 Mutter, R. W., Riaz, N., Ng, C. K. Y., Delsite, R., Piscuoglio, S., Edelweiss, M., . . . Powell, S. N. (2017). Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer. Journal of Pathology, 242(2), 165-177.
    DOI Scopus41 WoS40 Europe PMC33
    2017 Grzelak, C. A., Sigglekow, N. D., Tirnitz-Parker, J. E. E., Hamson, E. J., Warren, A., Maneck, B., . . . McCaughan, G. W. (2017). Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease. PLoS ONE, 12(2), e0171480-1-e0171480-23.
    DOI Scopus8 WoS8 Europe PMC5
    2017 Martelotto, L. G., Baslan, T., Kendall, J., Geyer, F. C., Burke, K. A., Spraggon, L., . . . Reis-Filho, J. S. (2017). Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples. Nature Medicine, 23(3), 376-385.
    DOI Scopus95 WoS88 Europe PMC68
    2017 Spraggon, L., Martelotto, L. G., Hmeljak, J., Hitchman, T. D., Wang, J., Wang, L., . . . Ladanyi, M. (2017). Generation of conditional oncogenic chromosomal translocations using CRISPR–Cas9 genomic editing and homology-directed repair. Journal of Pathology, 242(1), 102-112.
    DOI Scopus23 WoS22 Europe PMC17
    2017 Panter, S., Mouradov, A., Badenhorst, P., Martelotto, L., Griffith, M., Smith, K. F., & Spangenberg, G. (2017). Re-programming photosynthetic cells of perennial ryegrass (Lolium perenne L) for fructan biosynthesis through transgenic expression of fructan biosynthetic genes under the control of photosynthetic promoters. Agronomy, 7(2), 13 pages.
    DOI Scopus9 WoS8
    2017 Xue, Y., Martelotto, L., Baslan, T., Vides, A., Solomon, M., Mai, T. T., . . . Lito, P. (2017). An approach to suppress the evolution of resistance in BRAF V600E-mutant cancer. Nature Medicine, 23(8), 929-937.
    DOI Scopus109 WoS104 Europe PMC82
    2016 Chiang, S., Weigelt, B., Wen, H. C., Pareja, F., Raghavendra, A., Martelotto, L. G., . . . Schnitt, S. J. (2016). IDH2 mutations define a unique subtype of breast cancer with altered nuclear polarity. Cancer Research, 76(24), 7118-7129.
    DOI Scopus80 WoS69 Europe PMC50
    2016 Fusco, N., Geyer, F. C., De Filippo, M. R., Martelotto, L. G., Ng, C. K. Y., Piscuoglio, S., . . . Weigelt, B. (2016). Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer. Modern Pathology, 29(11), 1292-1305.
    DOI Scopus63 WoS50 Europe PMC33
    2016 Piscuoglio, S., Ng, C. K. Y., Murray, M. P., Guerini-Rocco, E., Martelotto, L. G., Geyer, F. C., . . . Reis-Filho, J. S. (2016). The genomic landscape of male breast cancers. Clinical Cancer Research, 22(16), 4045-4056.
    DOI Scopus105 WoS90 Europe PMC62
    2016 Piscuoglio, S., Ng, C. K. Y., Murray, M., Burke, K. A., Edelweiss, M., Geyer, F. C., . . . Reis-Filho, J. S. (2016). Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression. Journal of Pathology, 238(4), 508-518.
    DOI Scopus93 WoS83 Europe PMC59
    2016 Fusco, N., Colombo, P. E., Martelotto, L. G., De Filippo, M. R., Piscuoglio, S., Ng, C. K. Y., . . . Weigelt, B. (2016). Resolving quandaries: Basaloid adenoid cystic carcinoma or breast cylindroma? The role of massively parallel sequencing. Histopathology, 68(2), 262-271.
    DOI Scopus17 WoS16 Europe PMC14
    2016 Piscuoglio, S., Fusco, N., Ng, C. K. Y., Martelotto, L. G., da Cruz Paula, A., Katabi, N., . . . Reis-Filho, J. S. (2016). Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland. Histopathology, 68(7), 1055-1062.
    DOI Scopus24 WoS18 Europe PMC9
    2016 Schultheis, A. M., Martelotto, L. G., De Filippo, M. R., Piscuglio, S., Ng, C. K. Y., Hussein, Y. R., . . . Weigelt, B. (2016). TP53 mutational spectrum in endometrioid and serous endometrial cancers. International Journal of Gynecological Pathology, 35(4), 289-300.
    DOI Scopus72 WoS64 Europe PMC41
    2016 Piscuoglio, S., Burke, K. A., Ng, C. K. Y., Papanastasiou, A. D., Geyer, F. C., Macedo, G. S., . . . Weigelt, B. (2016). Uterine adenosarcomas are mesenchymal neoplasms. Journal of Pathology, 238(3), 381-388.
    DOI Scopus73 WoS73 Europe PMC46
    2015 Piscuoglio, S., Murray, M., Fusco, N., Marchiò, C., Loo, F. L., Martelotto, L. G., . . . Reis-Filho, J. S. (2015). MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast. Histopathology, 67(5), 719-729.
    DOI Scopus68 WoS58 Europe PMC45
    2015 Guerini-Rocco, E., Hodi, Z., Piscuoglio, S., Ng, C. K. Y., Rakha, E. A., Schultheis, A. M., . . . Reis-Filho, J. S. (2015). The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: An exploratory, hypothesis-generating study. Journal of Pathology, 237(2), 166-178.
    DOI Scopus46 WoS39 Europe PMC32
    2015 Martelotto, L. G., De Filippo, M. R., Ng, C. K., Natrajan, R., Fuhrmann, L., Cyrta, J., . . . Weigelt, B. (2015). Genomic landscape of adenoid cystic carcinoma of the breast. Journal of Pathology, 237(2), 179-189.
    DOI Scopus117 WoS105 Europe PMC81
    2015 Ng, C. K. Y., Martelotto, L. G., Gauthier, A., Wen, H. C., Piscuoglio, S., Lim, R. S., . . . Reis-Filho, J. S. (2015). Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification. Genome Biology, 16(1), 21 pages.
    DOI Scopus102 WoS91 Europe PMC66
    2014 Weinreb, I., Piscuoglio, S., Martelotto, L. G., Waggott, D., Ng, C. K. Y., Perez-Ordonez, B., . . . Reis-Filho, J. S. (2014). Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nature Genetics, 46(11), 1166-1169.
    DOI Scopus163 WoS132 Europe PMC108
    2014 Martelotto, L. G., Ng, C. K. Y., De Filippo, M. R., Zhang, Y., Piscuoglio, S., Lim, R. S., . . . Weigelt, B. (2014). Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations. Genome biology, 15(10), 484.
    DOI Scopus98 WoS90 Europe PMC82
    2014 Martelotto, L. G., Ng, C. K. Y., Piscuoglio, S., Weigelt, B., & Reis-Filho, J. S. (2014). Breast cancer intra-tumor heterogeneity. Breast Cancer Research, 16(3), 11 pages.
    DOI Scopus234 WoS206 Europe PMC154
    2014 Grzelak, C. A., Martelotto, L. G., Sigglekow, N. D., Patkunanathan, B., Ajami, K., Calabro, S. R., . . . McCaughan, G. W. (2014). The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury. Journal of Hepatology, 60(1), 143-151.
    DOI Scopus67 WoS57 Europe PMC42
    2014 Piscuoglio, S., Ng, C. K. Y., Martelotto, L. G., Eberle, C. A., Cowell, C. F., Natrajan, R., . . . Reis-Filho, J. S. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular Oncology, 8(8), 1588-1602.
    DOI Scopus41 WoS30 Europe PMC25
    2013 Zaitseva, M., Holdsworth-Carson, S. J., Waldrip, L., Nevzorova, J., Martelotto, L., Vollenhoven, B. J., & Rogers, P. A. W. (2013). Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids. Reproduction, 146(2), 91-102.
    DOI Scopus18 WoS16 Europe PMC15
    2013 Rossello, F. J., Tothill, R. W., Britt, K., Marini, K. D., Falzon, J., Thomas, D. M., . . . Watkins, D. N. (2013). Next-Generation Sequence Analysis of Cancer Xenograft Models. PLoS ONE, 8(9), e74432-1-e74432-12.
    DOI Scopus22 WoS21 Europe PMC17
    2013 Deane, J. A., Verghese, E., Martelotto, L. G., Cain, J. E., Galtseva, A., Rosenblum, N. D., . . . Ricardo, S. D. (2013). Visualizing renal primary cilia. Nephrology, 18(3), 161-168.
    DOI Scopus11 WoS10 Europe PMC9
    2013 Barakat, B., Yu, L., Lo, C., Vu, D., De Luca, E., Cain, J. E., . . . Hannigan, G. E. (2013). Erratum: Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling (EMBO Reports (2013) 14 ( 679-682) Doi:10.1038/embor.2013.97). EMBO Reports, 14(10), 945.
    DOI
    2013 Barakat, B., Yu, L., Lo, C., Vu, D., De Luca, E., Cain, J. E., . . . Hannigan, G. E. (2013). Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. EMBO Reports, 14(9), 837-844.
    DOI Scopus22 WoS23 Europe PMC21
    2011 Marini, K. D., Payne, B. J., Watkins, D. N., & Martelotto, L. G. (2011). Mechanisms of Hedgehog signalling in cancer. Growth Factors, 29(6), 221-234.
    DOI Scopus48 WoS42 Europe PMC33
    2011 Park, K. S., Martelotto, L. G., Peifer, M., Sos, M. L., Karnezis, A. N., Mahjoub, M. R., . . . Sage, J. (2011). A crucial requirement for Hedgehog signaling in small cell lung cancer. Nature Medicine, 17(11), 1504-1508.
    DOI Scopus206 WoS190 Europe PMC156
    2011 O'Toole, S. A., Machalek, D. A., Shearer, R. F., Millar, E. K. A., Nair, R., Schofield, P., . . . Swarbrick, A. (2011). Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Research, 71(11), 4002-4014.
    DOI Scopus128 WoS124 Europe PMC106
    2009 SPANGENBERG GERMAN., MOURADOV AIDYN., GRIFFITH MEGAN ELIZABETH., & MARTELOTTO LUCIANO GASTON. (2009). MODIFICATION OF FRUCTAN BIOSYNTHESIS, INCREASING PLANT BIOMASS, AND ENHANCING PRODUCTIVITY OF BIOCHEMICAL PATHWAYS IN A PLANT.
    2009 SPANGENBERG GERMAN., MOURADOV AIDYN., GRIFFITH MEGAN ELIZABETH., & MARTELOTTO LUCIANO GASTON. (2009). Modification of Fructan Biosynthesis, Increasing Plant Biomass, and Enhancing Productivitiy of Biochemical Pathways in a Plant.
    2009 SPANGENBERG GERMAN., MOURADOV AIDYN., GRIFFITH MEGAN ELIZABETH., & MARTELOTTO LUCIANO GASTON. (2009). MODIFICATION OF FRUCTAN BIOSYNTHESIS, INCREASING PLANT BIOMASS, AND ENHANCING PRODUCTIVITY OF BIOCHEMICAL PATHWAYS IN A PLANT.
    2008 Laspina, N. V., Vega, T., Seijo, J. G., González, A. M., Martelotto, L. G., Stein, J., . . . Pessino, S. C. (2008). Gene expression analysis at the onset of aposporous apomixis in Paspalum notatum. Plant Molecular Biology, 67(6), 615-628.
    DOI Scopus49 WoS49 Europe PMC40
    2008 Cervigni, G. D. L., Paniego, N., Díaz, M., Selva, J. P., Zappacosta, D., Zanazzi, D., . . . Echenique, V. (2008). Expressed sequence tag analysis and development of gene associated markers in a near-isogenic plant system of Eragrostis curvula. Plant Molecular Biology, 67(1-2), 1-10.
    DOI Scopus33 WoS45 Europe PMC20
    2007 Martelotto, L. G., Ortiz, J. P. A., Stein, J., Espinoza, F., Quarin, C. L., & Pessino, S. C. (2007). Genome rearrangements derived from autopolyploidization in Paspalum sp.. Plant Science, 172(5), 970-977.
    DOI Scopus48 WoS43 Europe PMC18
    2007 Mecchia, M. A., Ochogavía, A., Pablo Selva, J., Laspina, N., Felitti, S., Martelotto, L. G., . . . Pessino, S. C. (2007). Genome polymorphisms and gene differential expression in a 'back-and-forth' ploidy-altered series of weeping lovegrass (Eragrostis curvula). Journal of Plant Physiology, 164(8), 1051-1061.
    DOI Scopus25 WoS24 Europe PMC13
    2005 Martelotto, L. G., Ortiz, J. P. A., Stein, J., Espinoza, F., Quarin, C. L., & Pessino, S. C. (2005). A comprehensive analysis of gene expression alterations in a newly synthesized Paspalum notatum autotetraploid. Plant Science, 169(1), 211-220.
    DOI Scopus44 WoS41 Europe PMC24
    2003 Arabolaza, A. L., Nakamura, A., Pedrido, M. E., Martelotto, L., Orsaria, L., & Grau, R. R. (2003). Characterization of a novel inhibitory feedback of the anti-anti-sigma SpoIIAA on SpoOA activation during development in Bacillus subtilis. Molecular Microbiology, 47(5), 1251-1263.
    DOI Scopus26 WoS24 Europe PMC24
    2000 Martnez, M. L., Martelotto, L., & Cabada, M. O. (2000). Purification and biological characterization of N-acetyl β-D glucosaminidase from Bufo arenarum spermatozoa. Molecular Reproduction and Development, 57(2), 194-203.
    DOI Scopus34 WoS31 Europe PMC23
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 or Salty-Ez50 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v5.
    DOI
    - G Martelotto, L. (n.d.). snATAC-Seq on 10x ChromiumTM platform for fresh, frozen and cryopreserved material: my notes from the lab (UPDATED VERSION) v1.
    DOI
    - G Martelotto, L. (n.d.). snATAC-Seq on 10x ChromiumTM platform for fresh, frozen and cryopreserved material: my notes from the lab v1.
    DOI
    - Jiménes-Garcia, L. (n.d.). FixNCut v1.0 v1.
    DOI

  • Books
    Year Citation
    2005 Molecular breeding for the genetic improvement of forage crops and turf (2005). . Brill | Wageningen Academic.
    DOI

  • Book Chapters
    Year Citation
    2018 Chiang, S., Martelotto, L. G., & Weigelt, B. (2018). Genomic Applications in Gynecologic Malignancies. In Genomic Applications in Pathology: Second Edition 2019 (pp. 445-469). Springer International Publishing.
    DOI
    2015 Chiang, S., Martelotto, L. G., & Weigelt, B. (2015). Genomic Applications in Gynecologic Malignancies. In Genomic Applications in Pathology (pp. 465-487). Springer New York.
    DOI
    2005 Echenique, V., Felitti, S., Paniego, N., Martelotto, L., Pessino, S., Zanazzi, D., . . . Spangenberg, G. C. (2005). Discovery and functional categorisation of expressed sequence tags from flowers of Eragrostis curvula genotypes showing different ploidy levels and reproductive modes. In Molecular Breeding for The Genetic Improvement of Forage Crops and Turf: Proceedings of the 4th International Symposium on The Molecular Breeding of Forage and Turf, a Satellite Workshop of the XXth International Grassland Congress, July 2005, Aberystwyth, Wales (pp. 177).
    DOI
    2005 Martelotto, L. G., Ortiz, J. P. A., Espinoza, F., Quarin, C. L., & Pessino, S. C. (2005). A comprehensive analysis of gene expression and genomic alterations in a newly formed autotetraploid of Paspalum notatum. In Molecular Breeding for The Genetic Improvement of Forage Crops and Turf: Proceedings of the 4th International Symposium on The Molecular Breeding of Forage and Turf, a Satellite Workshop of the XXth International Grassland Congress, July 2005, Aberystwyth, Wales (pp. 178).
    DOI Scopus1

  • Conference Papers
    Year Citation
    2022 Pita-Juarez, Y., Martelotto, L., Kalavros, N., Ploumakis, A., Badlani, D., Huang, P., . . . Vlachos, I. (2022). SPATIAL TRANSCRIPTOMICS REVEALS EXTENSIVE CELLULAR RESTRUCTURING AND THE TRANSCRIPTIONAL LANDSCAPE IN PRIMARY SCLEROSING CHOLANGITIS. In HEPATOLOGY Vol. 76 (pp. S197-S198). WILEY.
    2015 Piscuoglio, S., Weinreb, I., Martelotto, L., Ng, C., Fusco, N., Rubin, B., . . . Reis-Filho, J. (2015). PRKD Gene Family Somatic Alterations in Polymorphous Low-Grade Adenocarcinomas of the Salivary Glands. In LABORATORY INVESTIGATION Vol. 95 (pp. 328A). Boston, MA: NATURE PUBLISHING GROUP.
    2015 Piscuoglio, S., Paula, A. D. C., Smolders, Y., Fusco, N., Martelotto, L., De Mattos-Arruda, L., . . . Weigelt, B. (2015). EWS16T Is a Useful Marker for the Detection of Microsatellite Instability in Endometrial Cancer. In LABORATORY INVESTIGATION Vol. 95 (pp. 302A). Boston, MA: NATURE PUBLISHING GROUP.
    2015 Fusco, N., Martelotto, L., Ng, C., Fuhrtnann, L., Cyrta, J., Guerini-Rocco, E., . . . Weigelt, B. (2015). Genetic Events in the Progression of Adenoid Cystic Carcinomas of the Breast To High-Grade Triple-Negative Breast Cancers. In LABORATORY INVESTIGATION Vol. 95 (pp. 45A). Boston, MA: NATURE PUBLISHING GROUP.
    2014 Piscuoglio, S., Ng, C. K., Martelotto, L. G., Eberle, C., Cowell, C. F., Natrajan, R., . . . Reis-Filho, J. S. (2014). Papillary Carcinomas of the Breast Have Distinctive Transcriptomic Profiles and Are Not Underpinned by a Highly Recurrent Fusion Gene. In MODERN PATHOLOGY Vol. 27 (pp. 75A-76A). San Diego, CA: NATURE PUBLISHING GROUP.
    2014 Martelotto, L. G., Ng, C. K., Lim, R., Piscuoglio, S., Natrajan, R., Wetterskog, D., . . . Weigelt, B. (2014). The Genomic Landscape of Adenoid Cystic Carcinoma of the Breast. In LABORATORY INVESTIGATION Vol. 94 (pp. 465A). San Diego, CA: NATURE PUBLISHING GROUP.
    2014 Piscuoglio, S., Wen, Y. H., Martelotto, L. G., Rocco, E. G., Akram, M., Jungbluth, A. A., . . . Reis-Filho, J. S. (2014). GATA3 Is a Marker of Estrogen Receptor-Positive but Not Estrogen Receptor-Negative Breast Cancers. In LABORATORY INVESTIGATION Vol. 94 (pp. 76A). San Diego, CA: NATURE PUBLISHING GROUP.
    2014 Marini, K. D., Rossello, F. J., Martelotto, L. G., & Watkins, D. N. (2014). Using synthetic lethal screening to identify therapeutic targets for innately platinum resistant lung cancer. In CANCER RESEARCH Vol. 74 (pp. 1 page). San Diego, CA: AMER ASSOC CANCER RESEARCH.
    DOI
    2013 Marini, K., Tothill, R., Britt, K., Falzon, J., Li, J., Bennett, S., . . . Rossello, F. (2013). DETERMINING READ ORIGIN OF NEXT-GENERATION SEQUENCING DATASETS FROM LUNG CANCER XENOGRAFTS. In JOURNAL OF THORACIC ONCOLOGY Vol. 8 (pp. S763). LIPPINCOTT WILLIAMS & WILKINS.
    2013 Marini, K., Rossello, F., Martelotto, L., & Watkins, N. (2013). USING SYNTHETIC LETHAL SCREENING TO IDENTIFY THERAPEUTIC TARGETS FOR INNATELY PLATINUM RESISTANT LUNG CANCER. In JOURNAL OF THORACIC ONCOLOGY Vol. 8 (pp. S352). LIPPINCOTT WILLIAMS & WILKINS.
    WoS1
    2011 Grzelak, C. A., Martelotto, L. G., Warner, F. J., Sigglekow, N. D., Patkunanathan, B., Watkins, D. N., . . . Mccaughan, G. W. (2011). The hedgehog pathway in hepatocellular liver injury progression. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 26 (pp. 13-14). WILEY-BLACKWELL.
    WoS1
    2011 Martelotto, L., Falzon, J., Bennett, S., Brown, T., & Watkins, N. (2011). AN IN-VIVO MODEL OF ACQUIRED CHEMORESISTANCE IN SMALL CELL LUNG CANCER. In JOURNAL OF THORACIC ONCOLOGY Vol. 6 (pp. S26). Melbourne, AUSTRALIA: ELSEVIER SCIENCE INC.
    2009 Peacock, C., Martelotto, L., Travaglione, V., McGovern, K., Read, M., Berman, D., . . . Watkins, D. (2009). Visualization of SMOOTHENED activation supports an essential role for Hedgehog signaling in the regulation of self-renewal in small cell lung cancer. In CANCER RESEARCH Vol. 69 (pp. 1 page). AMER ASSOC CANCER RESEARCH.

  • Datasets
    Year Citation
    - G Martelotto, L. (n.d.). &amp;#39;Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x Genomics Platform) v1.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v4.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v3.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for parallel snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation (UPDATED version) v5.
    DOI
    - G Martelotto, L. (n.d.). Daughter of Frankenstein protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® continuous gradient v2.
    DOI
    - G Martelotto, L. (n.d.). &amp;#39;Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x Genomics Platform) v2.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v2.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues using Salty-Ez10 buffer: compatible with snRNA-Seq and Multiome workflows from 10x Genomics v1.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation v2.
    DOI
    - G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v1.
    DOI
    - G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v2.
    DOI
    - G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v2 v1.
    DOI
    - G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v3.
    DOI
    - G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from fresh and frozen tissue for snRNAseq v1.
    DOI
    - G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v1.
    DOI
    - G Martelotto, L. (n.d.). S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v4.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation v1.
    DOI
    - G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v1.
    DOI
    - G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from fresh and frozen tissue for snRNAseq v2.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for parallel snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation (UPDATED version) v4.
    DOI
    - G Martelotto, L. (n.d.). Multi-Seq: my notes from the lab v1.
    DOI
    - G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x genomics Platform) v1.
    DOI
    - G Martelotto, L. (n.d.). ‘Frankenstein’ protocol for nuclei isolation from fresh and frozen tissue for snRNAseq v3.
    DOI
    - G Martelotto, L. (n.d.). Frankenstein’ protocol for nuclei isolation from FRESH and FROZEN tissue for snRNA-Seq (10x Genomics Platform) v1.
    DOI
    - G Martelotto, L. (n.d.). Protocol for nuclei isolation from fresh and frozen tissues for snRNA-Seq and snATAC-Seq on 10x ChromiumTM platform using the same nuclei preparation v3.
    DOI
    - G Martelotto, L. (n.d.). Daughter of Frankenstein protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® continuous gradient v1.
    DOI
Grants and Funding
GRANTS
Dissecting the mutational landscapes and cellular ecosystems of pancreatic cancer. NHMRC Grant APP1160855. Grant Amount: $854,384. Role: CIC. 2019
Resolving eosinophil and inflammatory heterogeneity in chronic allergic airway disease for safer, effective and lasting precision therapies. NHMRC Ideas Grant 2004288. Role: CIC. 2021
The PRECISE assay. Personalized medicine for cancer patients using next-generation sequencing. Monash Partners Consortium Research Grant 2016.  Role: Investigator. Grant amount: AU$116,000. Duration: 2017-2018

IN-KIND SUPPORT

Development of cutting-edge cancer genomics assays for solid and blood tumors 

  • NHMRC Project Grant (APP1098647, CIA Azad, $480,000)
  • RACP Fellowship Award (CIA Azad, $50,000)
  • Astellas Pharma Investigator-Initiated Study Grant (CIA Azad, $100,000)
  • Amgen Investigator-Initiated Study Grant (CIB Shortt, $200,000)

The PRECISE assay. Personalized medicine for cancer patients using next-generation sequencing.

  • A/Prof Arun Azad and A/Prof Jake Shortt signed a letter of commitment to the development of The PRECISE assay, providing:
    1. personalized medicine for cancer patients using next-generation sequencing by committing the involvement of our personnel (i.e. research assistant and PhD student);
    2. equipment (i.e. water baths, heat blocks, thermocyclers, etc.);
    3. in-kind contributions to support lab consumables (tips, tubes, PCR plates, etc.); and
    4. additional informatics support if needed.

 

Teaching Appointments
July 2020-present Chan Harvard Bioinformatics Single Cell Genomics Course. Harvard Medical School.  
Oct 2013 – March 2015

New York Academy of Sciences mentor for underrepresented children.                  Afterschool STEM mentoring program.

  
May 2000 – Oct 2004 Practical. Practical Tutor, General Biology. National University of Rosario (Argentina).  
Jan 2002 – Oct 2004 Tutor, Special Biology. National University of Rosario (Argentina).  

 

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2023 Co-Supervisor Somatic cell reprogramming of fibroblasts from different mammals to model early development. Doctor of Philosophy Doctorate Full Time Miss Elly Deidre Walters
    2023 Co-Supervisor How pluripotent transcription factors reshape the prostate cancer epigenetic landscape to reprogram the cell fate toward neuroendocrine-like with their cofactors Doctor of Philosophy Doctorate Full Time Mr Tianjun Zhang
  • Position: Head, Development Laboratory, ACE
  • Phone: 83138329
  • Email: luciano.martelotto@adelaide.edu.au
  • Campus: West End Health Precinct
  • Building: AHMS - Adelaide Health and Medical Sciences, floor Sixth Floor
  • Room: 6069
  • Org Unit: Faculty of Health and Medical Sciences
Connect With Me
External Profiles