Dr Loretta Dorstyn
Senior Research Fellow
Centre for Cancer Biology
College of Health
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
Dr Loretta Dorstyn (PhD, University of Adelaide) is a Senior Research Fellow and Project Leader at the Centre for Cancer Biology (CCB - UniSA and SA Pathology). Dr Dorstyn has over 20 years experience in molecular and cellular biology and understanding of the fundamental process of programmed cell death (termed apoptosis) during development and in disease, including the roles and activation mechanisms of the key apoptosis enzymes, caspases. She was awarded a RAH Florey Fellowship (2005), followed by a South Australian Cancer Collaborative Senior Research Fellowship (2012), when she was promoted to project leader at the CCB. Dr Dorstyn established several independent projects focussing on understanding cell death mechanisms important for cell homeostasis and genome integrity. Her projects led to numerous seminal findings detailing cell death mechanisms in tumour suppression, DNA damage repair, genomic stability, oxidative stress and healthy ageing.
Dr Dorstyn has spent the last 10 years studying mouse tumour models to better tumour suppression mechanisms and has gained extensive expertise in cancer biology. Dr Dorstyn's current work aims to understand how cells evade checkpoint or “safety net” mechanisms during cell division and acquire DNA alterations and mutations. This phenomenon is known as genomic instability and is one of the key hallmarks of ageing-related diseases such as cancer. Her current research focus is to understand how genomic instability increases with age and drives tissue damage, inflammation and age-related cancer including liver, gut and bone marrow cancers.
Tumour suppression by apoptotic Caspases
Caspases are the main enzymes that initiate and execute cell death by apoptosis. Our work has focussed on functional analysis of caspase-2, one of the first caspases discovered and has identified the apoptotic and non-apoptotic functions of this caspase. I was part of the team that described the function of caspase-2 in apoptosis induced by cytotoxic drugs that disrupt the cytoskeleton (Ho et al. 2008, Oncogene). This was followed by the first seminal demonstration that caspase-2 acts as a tumour suppressor in mice (Ho et al., 2009, Proc Natl Acad Sci USA). These findings led to further studies using various different mouse tumour models to define the role of caspase-2 in tumour suppression. In particular, the mouse thymoma model (Atm knockout mice) was used to demonstrate genetic interaction between Atm and caspase-2 in tumour suppression and enhanced tumour development in a caspase-2 knockout background (Puccini et al., 2013, Proc Natl Acad Sci USA). Interestingly, I also demonstrated that loss of caspase-2 can in fact delay tumour onset in a MYCN transgenic neuroblastoma mouse model (Dorstyn et al., 2014, Cell Death Dis). These findings indicated that caspase-2 has very defined tissue specific and context specific roles in tumour suppression and we are currently investigating the mechanisms by which it mediates these opposing functions.
Regulation of cellular stress pathways
- Caspase-2 function in genomic stability: My studies have demonstrated that loss of the caspase-2 gene leads to increased proliferation of primary fibroblasts, enhanced cell immortalisation and the accumulation of cells with DNA damage and aneuploidy (abnormal chromosome number) that drives genome instability (Dorstyn et al., 2012, Cell Death Differ). These studies also demonstrated that caspase-2 acts upstream of the tumour suppressor protein p53 in the DNA damage response pathway. Loss of caspase-2 significantly reduces p53 activation levels while stabilising c-Myc levels and our current work is aimed at understanding these roles. In further studies published in two recent papers (Dawar et al., 2017, Oncogene; Dawar et al., 2016, Cell Death Dis) we report that caspase-2 is essential for the efficient removal of cells carrying mitotic aberrations, especially those with abnormal nuclei or aneuploidy. We discovered that cells that lack caspase-2 have abnormal cell division “checkpoints” that normally prevent damaged cells from surviving and becoming aneuploid. As a consequence, ageing mice that are deficient in caspase-2 accumulate aneuploid cells in their tissues (e.g. bone marrow, spleen, liver) with ageing. These findings indicate that caspase-2 plays a critical role in preventing the long-term survival and growth of cells that could otherwise become malignant, thus proving a mechanism for tumour suppression by this caspase.
- Caspase-2 regulation of oxidative stress and ageing: In a paper published in Oncogene (Shalini et al., 2015), we demonstrated that caspase-2 deficiency exacerbates cellular stress in mice following low dose challenge with the potent reactive oxygen species (ROS) generator, paraquat (PQ). This was shown to be due to increased inflammation and impaired response to oxidative stress, including failure to upregulate the antioxidant defence mechanism in animals lacking caspase-2. Interestingly, we found that Casp2-/- mice exhibited more severe lung and liver lesions with extensive karyomegaly, a feature commonly associated with ageing and genomic instability. Thus, our work indicates that caspase-2 is critical in regulating the oxidative stress response and in preventing cellular stress and pre-mature ageing. We also made the direct demonstration that the absence of caspase-2 function and activity, accelerates oxidative stress-induced chronic liver cancer (hepatocellular carcinoma) as well as age-related chronic liver inflammation and HCC (Shalini et al., 2016, Cell Death Differ; Dorstyn et al., 2025 under review).
By preventing genomic instability and regulating the oxidative stress response, caspase-2 acts as a key cell surveillance protein and as a consequence is important to prevent tissue dysfunction and pre-mature ageing in mice. We are currently interested in understanding the molecular basis of these mechanisms in healthy ageing, maintaining normal tissue function and role in age-related diseases, including cancer.
| Date | Position | Institution name |
|---|---|---|
| 2022 - ongoing | Research Degree Coordinator | University of South Australia |
| 2012 - ongoing | Senior Research Fellow and Project Leader | University of South Australia |
| 2012 - 2015 | SACRC Senior Research Fellow | South Australia Pathology |
| 2009 - 2011 | Research Officer | South Australia Pathology |
| 2005 - ongoing | Affiliate Senior Lecturer | University of Adelaide |
| 2005 - 2008 | Royal Adelaide Hospital Florey Fellow | Royal Adelaide Hospital |
| 2001 - 2004 | Research Officer | Institute of Medical and Veterinary Sciences |
| Date | Type | Title | Institution Name | Country | Amount |
|---|---|---|---|---|---|
| 2012 | Fellowship | South Australian Cancer Research Collaborative Senior Research Fellowship | Cancer Council SA | Australia | - |
| 2005 | Fellowship | Royal Adelaide Hospital Florey Research Fellowship | Royal Adelaide Hospital | Australia | - |
| Date | Institution name | Country | Title |
|---|---|---|---|
| 1997 - 2001 | University of Adelaide | Australia | PhD |
| 1996 - 1996 | University of Adelaide | Australia | BSc - Honours (First Class) |
| 1993 - 1995 | University of Adelaide | Australia | BSc |
| Year | Citation |
|---|---|
| 2026 | Dorstyn, L., Lim, Y., Scanlan, J., McLennan, E., De Bellis, D., Katschner, M., . . . Kumar, S. (2026). Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice. Science Advances, 12(1), eaeb2571-1-eaeb2571-20. |
| 2024 | Umargamwala, R., Manning, J., Dorstyn, L., Denton, D., & Kumar, S. (2024). Understanding Developmental Cell Death Using Drosophila as a Model System. Cells, 13(4), 347-1-347-16. Scopus5 WoS3 Europe PMC2 |
| 2022 | Kumar, S., Dorstyn, L., & Lim, Y. (2022). The role of caspases as executioners of apoptosis. Biochemical Society Transactions, 50(1), 33-45. Scopus55 WoS47 Europe PMC43 |
| 2022 | Takahashi, C., & Kato, J. Y. (2022). Targeting Abnormal Cell Cycle in Cancer: A Preface to the Special Issue. Onco, 2(1), 34-35. Scopus1 |
| 2021 | Takahashi, C., & Kato, J. Y. (2021). Synthetic Inhibitors of CDK4/6 Activities and Tumor Suppression: A Preface to the Special Issue. Onco, 1(1), 1-2. |
| 2021 | Lim, Y., De Bellis, D., Sandow, J. J., Capalbo, L., D'Avino, P. P., Murphy, J. M., . . . Kumar, S. (2021). Phosphorylation by Aurora B kinase regulates caspase-2 activity and function.. Cell Death and Differentiation, 28(1), 349-366. Scopus29 WoS28 Europe PMC29 |
| 2021 | Lim, Y., Dorstyn, L., & Kumar, S. (2021). The p53-caspase-2 axis in the cell cycle and DNA damage response. Experimental and Molecular Medicine, 53(4), 517-527. Scopus48 WoS44 Europe PMC42 |
| 2021 | Sheng, J., Kohno, S., Okada, N., Okahashi, N., Teranishi, K., Matsuda, F., . . . Takahashi, C. (2021). Treatment of retinoblastoma 1-intact hepatocellular carcinoma with cyclin-dependent kinase 4/6 inhibitor combination therapy. Hepatology, 74(4), 1971-1993. Scopus35 WoS34 Europe PMC32 |
| 2021 | Linn, P., Kohno, S., Sheng, J., Kulathunga, N., Yu, H., Zhang, Z., . . . Takahashi, C. (2021). Targeting RB1 loss in cancers. Cancers, 13(15), 3737. Scopus56 |
| 2020 | Murata, T., Yamaguchi, M., Kohno, S., Takahashi, C., Risa, W., Hatori, K., . . . Kaneda, N. (2020). Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3-L1 cells. FEBS Open Bio, 10(10), 1967-1984. Scopus12 Europe PMC8 |
| 2020 | Thumkeo, D., Katsura, Y., Nishimura, Y., Kanchanawong, P., Tohyama, K., Ishizaki, T., . . . Narumiya, S. (2020). MDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse. Science Advances, 6(1), eaay2432. Scopus16 Europe PMC16 |
| 2020 | Kulathunga, N., Kohno, S., Linn, P., Nishimoto, Y., Horike, S. -I., Zaraiskii, M. I., . . . Takahashi, C. (2020). Peripubertal high-fat diet promotes c-Myc stabilization in mammary gland epithelium. Cancer Science, 111(7), 2336-2348. Scopus4 WoS4 Europe PMC6 |
| 2020 | Kohno, S., Linn, P., Nagatani, N., Watanabe, Y., Kumar, S., Soga, T., & Takahashi, C. (2020). Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Oncogene, 39(34), 5690-5707. Scopus14 WoS14 Europe PMC13 |
| 2020 | Dorstyn, L., Tvorogov, D., Malek, S., & Robinson, N. (2020). The 9th Barossa Meeting: Cell Signalling in Cancer Medicine. Cell Death and Disease, 11(3), 3 pages. |
| 2020 | Kitajima, S., Li, F., & Takahashi, C. (2020). Tumor milieu controlled by RB tumor suppressor. International Journal of Molecular Sciences, 21(7), E2450. Scopus25 Europe PMC20 |
| 2019 | Dorstyn, L., Hackett-Jones, E., Nikolic, A., Norris, M. D., Lim, Y., Toubia, J., . . . Kumar, S. (2019). Transcriptome profiling of caspase-2 deficient EµMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling. Cell Death and Disease, 10(2), 56-1-56-16. Scopus8 WoS7 Europe PMC7 |
| 2019 | Nishimura, T., Nakata, A., Chen, X., Nishi, K., Meguro-Horike, M., Sasaki, S., . . . Gotoh, N. (2019). Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. Oncogene, 38(14), 2464-2481. Scopus90 Europe PMC90 |
| 2019 | Li, F., Kitajima, S., Kohno, S., Yoshida, A., Tange, S., Sasaki, S., . . . Takahashi, C. (2019). Retinoblastoma inactivation induces a protumoral microenvironment via enhanced CCL2 secretion. Cancer Research, 79(15), 3903-3915. Scopus81 Europe PMC77 |
| 2018 | Kitajima, S., Asahina, H., Chen, T., Guo, S., Quiceno, L. G., Cavanaugh, J. D., . . . Barbie, D. A. (2018). Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS. Cancer Cell, 34(3), 439-452.e6. Scopus59 Europe PMC63 |
| 2018 | Zhao, J., Okamoto, Y., Asano, Y., Ishimaru, K., Aki, S., Yoshioka, K., . . . Takuwa, Y. (2018). Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages. Plos One, 13(5), e0197604. Scopus50 Europe PMC41 |
| 2018 | Murata, T., Yamaguchi, M., Kohno, S., Takahashi, C., Kakimoto, M., Sugimura, Y., . . . Kaneda, N. (2018). Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells. FEBS Open Bio, 8(3), 349-360. Scopus6 |
| 2018 | Sasaki, S., Baba, T., Muranaka, H., Tanabe, Y., Takahashi, C., Matsugo, S., & Mukaida, N. (2018). Involvement of prokineticin 2-expressing neutrophil infiltration in 5-fluorouracil-induced aggravation of breast cancer metastasis to lung. Molecular Cancer Therapeutics, 17(7), 1515-1525. Scopus38 Europe PMC34 |
| 2018 | Lim, Y., De Bellis, D., Dorstyn, L., & Kumar, S. (2018). p53 accumulation following cytokinesis failure in the absence of caspase-2. Cell Death and Differentiation, 25(11), 2050-2052. Scopus12 WoS11 Europe PMC11 |
| 2018 | Dorstyn, L., Akey, C. W., & Kumar, S. (2018). New insights into apoptosome structure and function. Cell Death and Differentiation, 25(7), 1194-1208. Scopus185 WoS176 Europe PMC158 |
| 2017 | Wilson, C., Nikolic, A., Kentish, S., Keller, M., Hatzinikolas, G., Dorstyn, L., . . . Kumar, S. (2017). Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity. Cell Death and Disease, 8(10), e3136-1-e3136-12. Scopus16 WoS15 Europe PMC15 |
| 2017 | Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., . . . Kumar, S. (2017). Caspase-2-mediated cell death is required for deleting aneuploid cells. Oncogene, 36(19), 2704-2714. Scopus56 WoS53 Europe PMC52 |
| 2017 | Nagata, N., Xu, L., Kohno, S., Ushida, Y., Aoki, Y., Umeda, R., . . . Ota, T. (2017). Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Diabetes, 66(5), 1222-1236. Scopus154 WoS142 Europe PMC120 |
| 2017 | Kitajima, S., & Takahashi, C. (2017). Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation. Cancer Science, 108(9), 1726-1731. Scopus35 Europe PMC31 |
| 2017 | Muranaka, H., Hayashi, A., Minami, K., Kitajima, S., Kohno, S., Nishimoto, Y., . . . Takahashi, C. (2017). A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling. Oncogenesis, 6(6), e350. Scopus30 |
| 2017 | Kitajima, S., Yoshida, A., Kohno, S., Li, F., Suzuki, S., Nagatani, N., . . . Takahashi, C. (2017). The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. Oncogene, 36(36), 5145-5157. Scopus47 Europe PMC45 |
| 2017 | Yoshida, A., Kitajima, S., Li, F., Cheng, C., Takegami, Y., Kohno, S., . . . Takahashi, C. (2017). MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6. Oncotarget, 8(8), 13872-13885. Scopus13 Europe PMC12 |
| 2016 | Hegazy, A. M., Yamada, D., Kobayashi, M., Kohno, S., Ueno, M., Ali, M. A. E., . . . Hirao, A. (2016). Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance. Journal of Biological Chemistry, 291(41), 21496-21509. Scopus32 Europe PMC30 |
| 2016 | Kohno, S., Kitajima, S., Sasaki, N., & Takahashi, C. (2016). Control of undifferentiated state by RB tumor suppressor. Seikagaku, 88(3), 335-341. |
| 2016 | Salah, M., Nishimoto, Y., Kohno, S., Kondoh, A., Kitajima, S., Muranaka, H., . . . Takahashi, C. (2016). An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal. Molecular Carcinogenesis, 55(12), 1974-1989. Scopus5 Europe PMC5 |
| 2016 | Kohno, S., Kitajima, S., Sasaki, N., & Takahashi, C. (2016). Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies. World Journal of Stem Cells, 8(4), 170-184. Scopus16 |
| 2016 | Wilson, C. H., Dorstyn, L., & Kumar, S. (2016). Fat, sex and caspase-2. Cell Death and Disease, 7(e2125), 1-2. Scopus2 WoS2 Europe PMC1 |
| 2016 | Shalini, S., Nikolic, A., Wilson, C., Puccini, J., Sladojevic, N., Finnie, J., . . . Kumar, S. (2016). Caspase-2 deficiency accelerates chemically induced liver cancer in mice. Cell Death and Differentiation, 23(10), 1727-1736. Scopus37 WoS34 Europe PMC31 |
| 2016 | Wilson, C., Nikolic, A., Kentish, S., Shalini, S., Hatzinikolas, G., Page, A., . . . Kumar, S. (2016). Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice. Cell Death Discovery, 2(16009), 16009-1-16009-10. Scopus18 WoS18 Europe PMC15 |
| 2016 | Dawar, S., Shahrin, N., Sladojevic, N., D'Andrea, R., Dorstyn, L., Hiwase, D., & Kumar, S. (2016). Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice. Cell Death and Disease, 7(12), e2509-1-e2509-9. Scopus27 WoS28 Europe PMC29 |
| 2015 | Wilson, C., Shalini, S., Filipovska, A., Richman, T., Davies, S., Martin, S., . . . Kumar, S. (2015). Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. Cell Death & Disease, 6(1), e1597-1-e1597-12. Scopus40 WoS39 Europe PMC36 |
| 2015 | Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S. (2015). Old, new and emerging functions of caspases. Cell Death and Differentiation, 22(4), 526-539. Scopus1102 WoS1034 Europe PMC879 |
| 2015 | Gutiérrez, J., Droppelmann, C. A., Contreras, O., Takahashi, C., & Brandan, E. (2015). RECK-mediated β1-integrin regulation by TGF-β1 is critical for wound contraction in mice. Plos One, 10(8), e0135005. Scopus13 Europe PMC11 |
| 2015 | Peintner, L., Dorstyn, L., Kumar, S., Aneichyk, T., Villunger, A., & Manzl, C. (2015). The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd. Cell Death and Differentiation, 22(11), 1803-1811. Scopus23 WoS21 Europe PMC17 |
| 2015 | Okahashi, N., Kohno, S., Kitajima, S., Matsuda, F., Takahashi, C., & Shimizu, H. (2015). Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations. Journal of Bioscience and Bioengineering, 120(6), 725-731. Scopus16 Europe PMC15 |
| 2015 | Kitajima, S., Kohno, S., Kondoh, A., Sasaki, N., Nishimoto, Y., Li, F., . . . Takahashi, C. (2015). Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells, 33(5), 1657-1669. Scopus22 Europe PMC21 |
| 2014 | Ali, M. A. E., Naka, K., Yoshida, A., Fuse, K., Kasada, A., Hoshii, T., . . . Hirao, A. (2014). Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients. Biochemical and Biophysical Research Communications, 450(1), 837-843. Scopus5 Europe PMC4 |
| 2014 | Dorstyn, L., & Kumar, S. (2014). Caspase-2 protocols. Methods in Molecular Biology, 1133, 71-87. WoS6 |
| 2014 | Rajabi, H. N., Takahashi, C., & Ewen, M. E. (2014). Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis. Journal of Biological Chemistry, 289(34), 23417-23427. Scopus18 Europe PMC17 |
| 2014 | Dorstyn, L., Puccini, J., Nikolic, A., Shalini, S., Wilson, C., Norris, M., . . . Kumar, S. (2014). An unexpected role for caspase-2 in neuroblastoma. Cell Death and Disease, 5(8), e1383-1-e1383-9. Scopus21 WoS20 Europe PMC16 |
| 2014 | Sandow, J., Dorstyn, L., O'Reilly, L., Tailler, M., Kumar, S., Strasser, A., & Ekert, P. (2014). ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death and Differentiation, 21(3), 475-480. Scopus52 WoS47 Europe PMC47 |
| 2014 | Shalini, S., Puccini, J., Wilson, C., Finnie, J., Dorstyn, L., & Kumar, S. (2014). Caspase-2 protects against oxidative stress in vivo. Oncogene, 34(38), 4995-5002. Scopus33 WoS28 Europe PMC25 |
| 2013 | Puccini, J., Dorstyn, L., & Kumar, S. (2013). Genetic background and tumour susceptibility in mouse models. Cell Death and Differentiation, 20(7), 964. Scopus13 WoS13 Europe PMC13 |
| 2013 | Puccini, J., Shalini, S., Voss, A., Gatei, M., Wilson, C., Hiwase, D., . . . Kumar, S. (2013). Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 110(49), 19920-19925. Scopus64 WoS58 Europe PMC57 |
| 2013 | Puccini, J., Dorstyn, L., & Kumar, S. (2013). Caspase-2 as a tumour suppressor. Cell Death and Differentiation, 20(9), 1133-1139. Scopus88 WoS84 Europe PMC70 |
| 2013 | Siddesha, J. M., Valente, A. J., Sakamuri, S. S. V. P., Yoshida, T., Gardner, J. D., Somanna, N., . . . Chandrasekar, B. (2013). Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK. Journal of Molecular and Cellular Cardiology, 65, 9-18. Scopus110 Europe PMC95 |
| 2013 | Shamma, A., Suzuki, M., Hayashi, N., Kobayashi, M., Sasaki, N., Nishiuchi, T., . . . Takahashi, C. (2013). ATM mediates prb function to control dnmt1 protein stability and dna methylation. Molecular and Cellular Biology, 33(16), 3113-3124. Scopus36 Europe PMC32 |
| 2013 | Hayashi, N., Kobayashi, M., Shamma, A., Morimura, Y., Takahashi, C., & Yamamoto, K. I. (2013). Regulatory interaction between NBS1 and DNMT1 responding to DNA damage. Journal of Biochemistry, 154(5), 429-435. Scopus6 Europe PMC6 |
| 2012 | Taura, M., Suico, M. A., Koyama, K., Komatsu, K., Miyakita, R., Matsumoto, C., . . . Kai, H. (2012). Rb/E2F1 regulates the innate immune receptor toll-like receptor 3 in epithelial cells. Molecular and Cellular Biology, 32(8), 1581-1590. Scopus28 Europe PMC25 |
| 2012 | Shalini, S., Dorstyn, L., Wilson, C., Puccini, J., Ho, L., & Kumar, S. (2012). Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death and Differentiation, 19(8), 1370-1380. Scopus82 WoS71 Europe PMC66 |
| 2012 | Dorstyn, L., Puccini, J., Wilson, C., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012). Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death and Differentiation, 19(8), 1288-1298. Scopus93 WoS90 Europe PMC84 |
| 2012 | Takahashi, C., Sasaki, N., & Kitajima, S. (2012). Twists in views on RB functions in cellular signaling, metabolism and stem cells. Cancer Science, 103(7), 1182-1188. Scopus30 Europe PMC27 |
| 2012 | Dorstyn, L., Puccini, J., Wilson, C. H., Shalini, S., Nicola, M., Moore, S., & Kumar, S. (2012). Erratum: Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability (Cell Death and Differentiation (2012) 19 (1288-1298) DOI: 10.1038/cdd.2012.36). Cell Death and Differentiation, 19(8), 1411. Scopus2 |
| 2011 | Wati, S., Rawlinson, S., Ivanov, R., Dorstyn, L., Beard, M., Jans, D., . . . Carr, J. (2011). Tumour necrosis factor alpha (TNF-α) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-α to activate nuclear factor κB and reduced sphingosine kinase-1 activity. Journal of General Virology, 92(4), 807-818. Scopus46 WoS46 Europe PMC44 |
| 2011 | Yuan, S., Yu, X., Topf, M., Dorstyn, L., Kumar, S., Ludtke, S., & Akey, C. (2011). Structure of the Drosophila apoptosome at 6.9 Å resolution. Structure, 19(1), 128-140. Scopus72 WoS66 Europe PMC58 |
| 2011 | Foot, N., Leong, Y., Dorstyn, L., Dalton, H., Ho, K., Zhao, L., . . . Kumar, S. (2011). Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis. Blood, 117(2), 638-646. Scopus41 WoS40 Europe PMC40 |
| 2011 | Kitajima, S., Miki, T., Takegami, Y., Kido, Y., Noda, M., Hara, E., . . . Takahashi, C. (2011). Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling. Oncogene, 30(6), 737-750. Scopus28 Europe PMC29 |
| 2010 | Miki, T., Shamma, A., Kitajima, S., Takegami, Y., Noda, M., Nakashima, Y., . . . Takahashi, C. (2010). The β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Molecular Cancer Research, 8(5), 665-676. Scopus32 Europe PMC27 |
| 2010 | Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., & Noda, M. (2010). Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs. Oncogene, 29(18), 2638-2648. Scopus100 Europe PMC86 |
| 2010 | Noda, M., Takahashi, C., Matsuzaki, T., & Kitayama, H. (2010). What we learn from transformation suppressor genes: Lessons from RECK. Future Oncology, 6(7), 1105-1116. Scopus17 Europe PMC15 |
| 2010 | Chandana, E. P., Maeda, Y., Ueda, A., Kiyonari, H., Oshima, N., Yamamoto, M., . . . Noda, M. (2010). Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Developmental Biology, 10(1), 84. Scopus45 Europe PMC41 |
| 2009 | Takahashi, C., Takegami, Y., & Shamma, A. (2009). The genetic and biochemical interactions of Rb and ras. Seikagaku, 81(10), 873-883. |
| 2009 | Takahashi, C., Muraguchi, T., Takegami, Y., & Miki, T. (2009). Regulation of Notch signaling and its polarity mediated by ectodomain shedding of DSL ligands. Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme, 54(13), 1742-1746. |
| 2009 | Shamma, A., Takegami, Y., Miki, T., Kitajima, S., Noda, M., Obara, T., . . . Takahashi, C. (2009). Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation. Cancer Cell, 15(4), 255-269. Scopus121 Europe PMC100 |
| 2009 | Omura, A., Matsuzaki, T., Mio, K., Ogura, T., Yamamoto, M., Fujita, A., . . . Noda, M. (2009). RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin. Journal of Biological Chemistry, 284(6), 3461-3469. Scopus53 Europe PMC50 |
| 2009 | Kumar, S., & Dorstyn, L. (2009). Analysing caspase activation and caspase activity in apoptotic cells. Methods in Molecular Biology, 559, 3-17. Scopus17 WoS15 Europe PMC12 |
| 2009 | Howitt, J., Putz, U., Lackovic, J., Doan, A., Dorstyn, L., Cheng, H., . . . Tan, S. (2009). Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15489-15494. Scopus105 WoS104 Europe PMC100 |
| 2009 | Ho, L., Taylor, R., Dorstyn, L., Cakouros, D., Bouillet, P., & Kumar, S. (2009). A tumor suppressor function for caspase-2. Proceedings of the National Academy of Sciences of the United States of America, 106(13), 5336-5341. Scopus154 WoS142 Europe PMC138 |
| 2009 | Dorstyn, L., & Kumar, S. (2009). Putative functions of caspase-2. F1000 biology reports, 1(96), 1-5. Europe PMC2 |
| 2008 | Ho, L., Read, S., Dorstyn, L., Lambrusco, L., & Kumar, S. (2008). Capase-2 is required for cell death induced by cytoskeletal disruption. Oncogene, 27(24), 3393-3404. Scopus112 WoS104 Europe PMC102 |
| 2008 | Foot, N., Dalton, H., Shearwin-Whyatt, L., Dorstyn, L., Tan, S., Yang, B., & Kumar, S. (2008). Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood, 112(10), 4268-4275. Scopus127 WoS119 Europe PMC118 |
| 2008 | Dorstyn, L., & Kumar, S. (2008). A biochemical analysis of the activation of the Drosophila caspase DRONC. Cell Death and Differentiation, 15(3), 461-470. Scopus54 WoS48 Europe PMC43 |
| 2008 | Kawashima, S., Imamura, Y., Chandana, E. P. S., Noda, T., Takahashi, R., Adachi, E., . . . Noda, M. (2008). Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions. Journal of Neurochemistry, 104(2), 376-385. Scopus17 Europe PMC13 |
| 2007 | Miki, T., Takegami, Y., Okawa, K., Muraguchi, T., Noda, M., & Takahashi, C. (2007). The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. Journal of Biological Chemistry, 282(16), 12341-12352. Scopus81 Europe PMC71 |
| 2007 | Muraguchi, T., Takegami, Y., Ohtsuka, T., Kitajima, S., Chandana, E. P. S., Omura, A., . . . Takahashi, C. (2007). RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity. Nature Neuroscience, 10(7), 838-845. Scopus145 Europe PMC117 |
| 2007 | Doumanis, J., Dorstyn, L., & Kumar, S. (2007). Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY. Cell Death and Differentiation, 14(5), 907-915. Scopus27 WoS27 Europe PMC23 |
| 2007 | Noda, M., & Takahashi, C. (2007). Recklessness as a hallmark of aggressive cancer. Cancer Science, 98(11), 1659-1665. Scopus92 Europe PMC79 |
| 2007 | Fotiadou, P. P., Takahashi, C., Rajabi, H. N., & Ewen, M. E. (2007). Wild-type NRas and KRas perform distinct functions during transformation. Molecular and Cellular Biology, 27(19), 6742-6755. Scopus43 Europe PMC40 |
| 2006 | Takahashi, C., & Ewen, M. E. (2006). Genetic interaction between Rb and N-ras: Differentiation control and metastasis. Cancer Research, 66(19), 9345-9348. Scopus15 Europe PMC11 |
| 2006 | Dorstyn, L., & Kumar, S. (2006). A cytochrome c-free fly apoptosome. Cell Death and Differentiation, 13(7), 1049-1051. Scopus27 WoS24 Europe PMC22 |
| 2006 | Takahashi, C., Contreras, B., Iwanaga, T., Takegami, Y., Bakker, A., Bronson, R. T., . . . Ewen, M. E. (2006). Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor. Nature Genetics, 38(1), 118-123. Scopus46 Europe PMC41 |
| 2006 | Nakaji, K., Ihara, M., Takahashi, C., Itohara, S., Noda, M., Takahashi, R., & Tomimoto, H. (2006). Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents. Stroke, 37(11), 2816-2823. Scopus139 Europe PMC115 |
| 2005 | Echizenya, M., Kondo, S., Takahashi, R., Oh, J., Kawashima, S., Kitayama, H., . . . Noda, M. (2005). The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors. Oncogene, 24(38), 5850-5857. Scopus47 Europe PMC39 |
| 2005 | Takenaka, K., Ishikawa, S., Yanagihara, K., Miyahara, R., Hasegawa, S., Otake, Y., . . . Tanaka, F. (2005). Prognostic significance of reversion-inducing cysteine-rich protein with Kazal motifs expression in resected pathologic stage IIIA N2 Non-small-cell lung cancer. Annals of Surgical Oncology, 12(10), 817-824. Scopus28 Europe PMC22 |
| 2005 | Ihara, M., Kinoshita, A., Yamada, S., Tanaka, H., Tanigaki, A., Kitano, A., . . . Kinoshita, M. (2005). Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Developmental Cell, 8(3), 343-352. Scopus248 Europe PMC231 |
| 2004 | Takahashi, C., Contreras, B., Bronson, R. T., Loda, M., & Ewen, M. E. (2004). Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Molecular and Cellular Biology, 24(23), 10406-10415. Scopus35 Europe PMC31 |
| 2004 | Dorstyn, L., Mills, K., Lazebnik, Y., & Kumar, S. (2004). The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. Journal of Cell Biology, 167(3), 405-410. Scopus110 WoS105 Europe PMC98 |
| 2004 | Takenaka, K., Ishikawa, S., Kawano, Y., Yanagihara, K., Miyahara, R., Otake, Y., . . . Tanaka, F. (2004). Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer. European Journal of Cancer, 40(10), 1617-1623. Scopus95 Europe PMC79 |
| 2004 | Takeuchi, T., Hisanaga, M., Nagao, M., Ikeda, N., Fujii, H., Koyama, F., . . . Nakajima, Y. (2004). The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. Clinical Cancer Research, 10(16), 5572-5579. Scopus107 Europe PMC89 |
| 2004 | Oh, J., Takahashi, R., Adachi, E., Kondo, S., Kuratomi, S., Noma, A., . . . Noda, M. (2004). Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice. Oncogene, 23(29), 5041-5048. Scopus116 Europe PMC96 |
| 2004 | Oh, J., Seo, B. W., Diaz, T., Wei, B., Ward, Y., Ray, J. M., . . . Sletler-Stevenson, W. G. (2004). Tissue inhibitors of metalloproteinase 2 inhibits endothelial cell migration through increased expression of RECK. Cancer Research, 64(24), 9062-9069. Scopus105 Europe PMC93 |
| 2003 | Takahashi, C., Bronson, R. T., Socolovsky, M., Contreras, B., Lee, K. Y., Jacks, T., . . . Ewen, M. E. (2003). Rb and N-ras function together to control differentiation in the mouse. Molecular and Cellular Biology, 23(15), 5256-5268. Scopus49 Europe PMC41 |
| 2003 | Arai, T., Kasper, J. S., Skaar, J. R., Ali, S. H., Takahashi, C., & DeCaprio, J. A. (2003). Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proceedings of the National Academy of Sciences of the United States of America, 100(17), 9855-9860. Scopus137 Europe PMC115 |
| 2003 | Noda, M., Oh, J., Takahashi, R., Kondo, S., Kitayama, H., & Takahashi, C. (2003). RECK: A novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling. Cancer and Metastasis Reviews, 22(2-3), 167-175. Scopus131 Europe PMC105 |
| 2002 | Sasahara, R. M., Brochado, S. M., Takahashi, C., Oh, J., Maria-Engler, S. S., Granjeiro, J. M., . . . Sogayar, M. C. (2002). Transcriptional control of the RECK metastasis/angiogenesis suppressor gene. Cancer Detection and Prevention, 26(6), 435-443. Scopus51 Europe PMC40 |
| 2002 | Dorstyn, L., Read, S., Cakouros, D., Huh, J., Hay, B., & Kumar, S. (2002). The role of cytochrome c in caspase activation in Drosophila melanogaster cells. Journal of Cell Biology, 156(6), 1089-1098. Scopus173 WoS166 Europe PMC152 |
| 2002 | Takahashi, C., Junseo, O., & Noda, M. (2002). The membrane-anchored metalloproteinase inhibitor RECK. Tanpakushitsu Kakusan Koso Protein Nucleic Acid Enzyme, 47(14), 1889-1895. Scopus1 Europe PMC1 |
| 2001 | Harvey, N., Daish, T., Mills, K., Dorstyn, L., Quinn, L., Read, S., . . . Kumar, S. (2001). Characterization of the Drosophila caspase, DAMM. Journal of Biological Chemistry, 276(27), 25342-25350. Scopus76 WoS67 Europe PMC64 |
| 2001 | Furumoto, K., Arii, S., Mori, A., Furuyama, H., Rivas, M. J. G., Nakao, T., . . . Imamura, M. (2001). RECK gene expression in hepatocellular carcinoma: Correlation with invasion-related clinicopathological factors and its clinical significance. Hepatology, 33(1), 189-195. Scopus89 Europe PMC69 |
| 2001 | Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R. M., . . . Noda, M. M. (2001). The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell, 107(6), 789-800. Scopus646 Europe PMC508 |
| 2000 | Quinn, L., Dorstyn, L., Mills, K., Colussi, P., Chen, P., Coombe, M., . . . Richardson, H. (2000). An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. Journal of Biological Chemistry, 275(51), 40416-40424. Scopus137 WoS133 Europe PMC122 |
| 2000 | Dorstyn, L., Read, S. H., Quinn, L. M., Richardson, H., & Kumar, S. (2000). DECAY, a novel <i>Drosophila</i> caspase related to mammalian caspase-3 and caspase-7 (vol 274, pg 30778, 1999). JOURNAL OF BIOLOGICAL CHEMISTRY, 275(20), 15600. WoS1 |
| 2000 | Dorstyn, L., Read, S. H., Quinn, L. M., Richardson, H., & Kumar, S. (2000). Erratum: DECAY, a novel Drosophila caspase related to mammalian caspase- 3 and caspase-7 (Journal of Biological Chemistry (1999) 274 (30778-30783)). Journal of Biological Chemistry, 275(20), 15600. |
| 1999 | Sasahara, R. M., Takahashi, C., & Noda, M. (1999). Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene. Biochemical and Biophysical Research Communications, 264(3), 668-675. Scopus99 Europe PMC80 |
| 1999 | Dorstyn, L., Read, S., Quinn, L., Richardson, H., & Kumar, S. (1999). DECAY, a novel Drosophila caspase related to mammalian Caspase-3 and Caspase-7. Journal of Biological Chemistry, 274(43), 30778-30783. Scopus113 WoS107 Europe PMC95 |
| 1999 | Dorstyn, L., Colussi, P., Quinn, L., Richardson, H., & Kumar, S. (1999). DRONC, an ecdysone-inducible Drosophila caspase. Proceedings of the National Academy of Sciences of the United States of America, 96(36251), 4307-4312. Scopus255 WoS249 Europe PMC216 |
| 1999 | Sasahara, R. M., Takahashi, C., Sogayar, M. C., & Noda, M. (1999). Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene. Brazilian Journal of Medical and Biological Research, 32(7), 891-895. Scopus20 Europe PMC18 |
| 1998 | Ishida-Takahashi, A., Otani, H., Takahashi, C., Washizuka, T., Tsuji, K., Noda, M., . . . Sasayama, S. (1998). Cystic fibrosis transmembrane conductance regulator mediates sulphonylurea block of the inwardly rectifying K+ channel Kir6.1. Journal of Physiology, 508(1), 23-30. Scopus34 Europe PMC23 |
| 1998 | Takahashi, C., Sheng, Z., Horan, T. P., Kitayama, H., Maki, M., Hitomi, K., . . . Noda, M. (1998). Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proceedings of the National Academy of Sciences of the United States of America, 95(22), 13221-13226. Scopus450 Europe PMC357 |
| 1997 | Dorstyn, L., & Kumar, S. (1997). Differential inhibitory effects of CrmA, P35, IAP and three mammalian IAP homologues on apoptosis in NIH3T3 cells following various death stimuli. Cell Death and Differentiation, 4(7), 570-579. Scopus26 WoS26 Europe PMC22 |
| 1997 | Kumar, S., Kinoshita, M., Dorstyn, L., & Noda, M. (1997). Origin, expression and possible functions of the two alternatively spliced forms of the mouse Nedd2 mRNA. Cell Death and Differentiation, 4(5), 378-387. Scopus28 WoS28 |
| 1996 | Takahashi, C., Akiyama, N., Matsuzaki, T., Takai, S., Kitayama, H., & Noda, M. (1996). Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene. Oncogene, 12(10), 2137-2146. Scopus48 Europe PMC41 |
| 1992 | Adachi, Y., Copeland, T. D., Takahashi, C., Nosaka, T., Ahmed, A., Oroszlan, S., & Hatanaka, M. (1992). Phosphorylation of the Rex protein of human T-cell leukemia virus type I. Journal of Biological Chemistry, 267(30), 21977-21981. Scopus45 Europe PMC33 |
| 1991 | Adachi, Y., Ishida-Takahashi, A., Takahashi, C., Takano, E., Murachi, T., & Hatanaka, M. (1991). Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells. Journal of Biological Chemistry, 266(6), 3968-3972. Scopus63 Europe PMC41 |
| 1990 | Tanaka, A., Takahashi, C., Yamaoka, S., Nosaka, T., Maki, M., & Hatanaka, M. (1990). Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proceedings of the National Academy of Sciences of the United States of America, 87(3), 1071-1075. Scopus415 Europe PMC313 |
| Year | Citation |
|---|---|
| 2014 | Dorstyn, L., & Kumar, S. (2014). Caspase-2 protocols. In P. Bozhkov, & G. Salvasen (Eds.), Caspases, paracaspases and metacaspases: methods and protocols (Vol. 1133, pp. 71-87). Humana Press. DOI Scopus6 Europe PMC7 |
| 2013 | Dorstyn, L., & Kumar, S. (2013). Insect Caspases. In N. Rawlings, & G. Salvesen (Eds.), Handbook of Proteolytic Enzymes, Volume 2 (Vol. 2, 3 ed., pp. 2286-2295). United Kingdom: Elsevier. DOI Scopus1 WoS1 |
| 2005 | Dorstyn, L., & Kumar, S. (2005). Programmed cell death in drosophila melanogaster. In When Cells Die II A Comprehensive Evaluation of Apoptosis and Programmed Cell Death (pp. 79-97). Wiley. DOI Scopus1 |
| 1998 | Dorstyn, L. E., Kumar, S., & Kinoshita, M. (1998). Caspases in Cell Death. In S. Kumar (Ed.), Apoptosis: Mechanisms and Role in Disease (Vol. 24, pp. 1-24). Springer New York. DOI Scopus12 Europe PMC4 |
| Year | Citation |
|---|---|
| 2000 | Izumi, H., Takahashi, C., Oh, J., & Noda, M. (2000). Tissue factor pathway inhibitor-2 suppresses the production of active matrix metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes. In FEBS Letters Vol. 481 (pp. 31-36). England: Wiley. DOI Scopus73 Europe PMC47 |
| Year | Citation |
|---|---|
| 2022 | Kumar, S., Lim, Y., & Dorstyn, L. (2022). Tumor and aneuploidy suppression by caspase-2. Poster session presented at the meeting of CANCER SCIENCE. WILEY. |
| Year | Citation |
|---|---|
| 2024 | Fujita, H., Arai, S., Arakawa, H., Hamamoto, K., Kato, T., Arai, T., . . . Watanabe, Y. (2024). Drug–drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers. DOI |
| 2022 | Noyes, C., Kitajima, S., Li, F., Suita, Y., Miriyala, S., Isaac, S., . . . Yajima, M. (2022). The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells. DOI |
| 2021 | Okahashi, N., Shima, T., Kondo, Y., Araki, C., Tsuji, S., Sawai, A., . . . Matsuda, F. (2021). Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells. DOI |
| 2020 | Hu, H. T., Sasakura, N., Matsubara, D., Furusawa, N., Mukai, M., Kitamura, N., . . . Suetsugu, S. (2020). Involvement of I-BAR protein IRSp53 in tumor cell growth via extracellular microvesicle secretion. DOI |
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Deciphering the mechanisms of caspase-2-mediated suppression of aneuploidy and tumourigenesis, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
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Using mouse models to decipher the function of caspase-2 in limiting aneuploidy tolerance and cancer, NHMRC - Project Grant, 01/01/2018 - 30/06/2021
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Deciphering the function of capcase-2 in DNA damage response and tumour suppression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2025 | Principal Supervisor | Exploring the mechanisms of age-related polyploidy in inflammation and liver cancer | Doctor of Philosophy | Doctorate | Full Time | Mr Manish Kumar Vuriti |
| Date | Role | Research Topic | Program | Degree Type | Student Load | Student Name |
|---|---|---|---|---|---|---|
| 2012 - 2016 | Co-Supervisor | Characterisation of Pathophysiological Function of NEDD4-2 in Kidney | Doctor of Philosophy | Doctorate | Full Time | Mr Pranay Goel |
| 2010 - 2014 | Co-Supervisor | Characterisation of Caspase-2 Function in the DNA Damage Response and Tumour Suppression | Doctor of Philosophy | Doctorate | Full Time | Mr Joey Puccini |
| Date | Role | Committee | Institution | Country |
|---|---|---|---|---|
| 2019 - 2023 | Member | Conference Organising Committee | Centre for Cancer Biology | Australia |
| 2014 - ongoing | Member | Centre for Cancer Biology Faculty | Centre for Cancer Biology | Australia |
| 2011 - ongoing | Member | NHMRC GRP | National Health and Medical Research Council | Australia |
| 2010 - ongoing | Member | F1000 Associate Member | Faculty of 1000 (United States) | United States |
| Date | Role | Membership | Country |
|---|---|---|---|
| 2020 - ongoing | Member | Australasian Cell Death Society | - |
| 2012 - ongoing | Member | Australia and New Zealand Society for Cell and Developmental Biology | - |
| 2012 - ongoing | Member | Australian Society for Medical Research | - |
| 2002 - ongoing | Member | The Australian Society for Biochemistry and Molecular Biology | - |
| Date | Title | Engagement Type | Institution | Country |
|---|---|---|---|---|
| 2027 - 2017 | Researchers find link between common enzyme and cancer prevention | Scientific Community Engagement | Medical Xpress (online article) | Australia |
| 2014 - 2017 | Researcher Showcase Discussion Panel (Public Event) | Public Community Engagement | Cancer Council SA | Australia |
| 2009 - ongoing | Caspase-2 | Scientific Community Engagement | Springer Nature (United Kingdom) | United Kingdom |
| Date | Role | Editorial Board Name | Institution | Country |
|---|---|---|---|---|
| 2024 - ongoing | Member | Frontiers in Cell Death -Community reviewer for Inflammation and Cytotoxicity | Frontiers in Cell Death | United States |
| Date | Title | Type | Institution | Country |
|---|---|---|---|---|
| 2024 - ongoing | Grant Review | Grant Assessment | Swiss National Science Foundation | Switzerland |
| 2019 - ongoing | Grant Review | Grant Assessment | Health Research Council of New Zealand | New Zealand |
| 2018 - ongoing | Grant Review | Grant Assessment | National Science Foundation | United States |
| 2011 - ongoing | Grant Review | Grant Assessment | National Health and Medical Research Council | Australia |
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