Dr Loretta Chin

NHMRC Postdoctoral Research Officer (A)

School of Biomedicine

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Loretta Chin is a postdoctoral research officer within the Reproductive Immunology laboratory at The University of Adelaide’s, Robinson Research Institute. Since completing her PhD at The University of Adelaide in 2014, under the supervision of Professors Sarah Robertson and Jeremy Thompson, focusing on the impact of an inflammatory peri-conceptual environment on the developing embryo, Loretta has continued her postdoctoral training within the Robertson laboratory where she now investigates immune pathways as potential targets to prevent inflammation and infection induced preterm birth. Her recent work has identified the TLR4 pathway as being critical in controlling the inflammatory activation that precedes preterm and normal term delivery.

Career
Publications
Supervision
Contact

Appointments

Date Position Institution name

2014 - ongoing Postdoctoral Research Officer University of Adelaide
Language Competencies

Language Competency

English Can read, write, speak, understand spoken and peer review

Malay Can read, write, speak and understand spoken
Education

Date Institution name Country Title

2014 University of Adelaide Adelaide PhD

2008 University of Adelaide Adelaide B. Sc. (Hons)

2007 University of Adelaide Adelaide B.Sc. (Biotechnology)

Date	Position	Institution name
2014 - ongoing	Postdoctoral Research Officer	University of Adelaide

Language	Competency
English	Can read, write, speak, understand spoken and peer review
Malay	Can read, write, speak and understand spoken

Date	Institution name	Country	Title
2014	University of Adelaide	Adelaide	PhD
2008	University of Adelaide	Adelaide	B. Sc. (Hons)
2007	University of Adelaide	Adelaide	B.Sc. (Biotechnology)

Journals

Year	Citation
2021	Tangseefa, P., Martin, S. K., Chin, P. Y., Breen, J., Mah, C. Y., Baldock, P. A., . . . Zannettino, A. C. W. (2021). The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin. Bone Research, 9(1), 10-1-10-17. DOI Scopus1 WoS2 Europe PMC2
2021	Schjenken, J. E., Moldenhauer, L. M., Sharkey, D. J., Chan, H. Y., Chin, P. Y., Fullston, T., . . . Robertson, S. A. (2021). High fat diet alters male seminal plasma composition to impair female immune adaptation for pregnancy in mice. Endocrinology, 162(10), 1-20. DOI Scopus4 WoS5 Europe PMC2
2021	Gomez-Lopez, N., Garcia-Flores, V., Chin, P. Y., Groome, H. M., Bijland, M. T., Diener, K. R., . . . Robertson, S. A. (2021). Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury. JCI Insight, 6(19), e146089-1-e146089-22. DOI Scopus8 WoS8 Europe PMC6
2020	Wahid, H. H., Chin, P. Y., Sharkey, D. J., Diener, K. R., Hutchinson, M. R., Rice, K. C., . . . Robertson, S. A. (2020). Toll-like receptor-4 antagonist (+)-naltrexone protects against carbamyl-platelet activating factor (Cpaf)-induced preterm labor in mice. American Journal of Pathology, 190(5), 1030-1045. DOI Scopus9 WoS10 Europe PMC5
2020	Kieffer, T. E. C., Chin, P. Y., Green, E. S., Moldenhauer, L. M., Prins, J. R., & Robertson, S. A. (2020). Prednisolone in early pregnancy inhibits regulatory T cell generation and alters fetal and placental development in mice. Molecular Human Reproduction, 26(5), 340-352. DOI Scopus7 WoS7 Europe PMC4
2020	Robertson, S. A., Hutchinson, M. R., Rice, K. C., Chin, P. -Y., Moldenhauer, L. M., Stark, M. J., . . . Keelan, J. A. (2020). Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury. Clinical and Translational Immunology, 9(4), e1121-1-e1121-19. DOI WoS9 Europe PMC6
2019	Chin, P. Y., Dorian, C., Sharkey, D. J., Hutchinson, M. R., Rice, K. C., Moldenhauer, L. M., & Robertson, S. A. (2019). Toll-like receptor-4 antagonist (+)-naloxone confers sexually dimorphic protection from inflammation-induced fetal programming in mice. Endocrinology, 160(11), 2646-2662. DOI Scopus7 WoS8 Europe PMC7
2018	Robertson, S., Chin, P. -Y., Femia, J., & Brown, H. (2018). Embryotoxic cytokines-Potential roles in embryo loss and fetal programming. Journal of reproductive immunology, 125, 80-88. DOI Scopus60 WoS54 Europe PMC29
2018	Robertson, S., Wahid, H., Chin, P., Hutchinson, M., Moldenhauer, L., & Keelan, J. (2018). Toll-like receptor-4: A new target for preterm labour pharmacotherapies?. Current Pharmaceutical Design, 24(9), 960-973. DOI Scopus15 WoS17 Europe PMC10
2017	Nadeau-Vallée, M., Chin, P., Belarbi, L., Brien, M., Pundir, S., Berryer, M., . . . Chemtob, S. (2017). Antenatal suppression of il-1 protects against inflammation-induced fetal injury and improves neonatal and developmental outcomes in mice. Journal of Immunology, 198(5), 2047-2062. DOI Scopus72 WoS72 Europe PMC42
2016	Chin, P., Dorian, C., Hutchinson, M., Olson, D., Rice, K., Moldenhauer, L., & Robertson, S. (2016). Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports, 6(1), 36112-1-36112-13. DOI Scopus46 WoS46 Europe PMC33
2015	Wahid, H., Dorian, C., Chin, P., Hutchinson, M., Rice, K., Olson, D., . . . Robertson, S. (2015). Toll-like receptor 4 Is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology, 156(10), 3828-3841. DOI Scopus43 WoS41 Europe PMC27
2014	Dasari, P., Sharkey, D., Noordin, E., Glynn, D., Hodson, L., Chin, P., . . . Ingman, W. (2014). Hormonal regulation of the cytokine microenvironment in the mammary gland. Journal of Reproductive Immunology, 106, 58-66. DOI Scopus12 WoS12 Europe PMC10
2014	Bromfield, J., Schjenken, J., Chin, P., Care, A., Jasper, M., & Robertson, S. (2014). Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring. PNAS, 111(6), 2200-2205. DOI Scopus238 WoS229 Europe PMC144
2011	Robertson, S., Chin, P., Glynn, D., & Thompson, J. (2011). Peri-conceptual cytokines - Setting the trajectory for embryo implantation, pregnancy and beyond. American Journal of Reproductive Immunology (Print), 66(Suppl 1), 2-10. DOI Scopus52 WoS48 Europe PMC27
2009	Chin, P., Macpherson, A., Thompson, J., Lane, M., & Robertson, S. (2009). Stress response genes are suppressed in mouse preimplantation embryos by granulocyte-macrophage colony-stimulating factor (GM-CSF). Human Reproduction, 24(12), 2997-3009. DOI Scopus47 WoS44 Europe PMC32
	Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone attenuates fetal programming of offspring growth and adiposity in mice: Supplemental Tables S1-S3. DOI
	Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Tables 1-5. DOI

Book Chapters

Year	Citation
2015	Robertson, S., Chin, P. -Y., Schjenken, J., & Thompson, J. (2015). Female tract cytokines and developmental programming in embryos. In H. Leese, & D. Brison (Eds.), Cell signalling during mammalian early embryo development (Vol. 843, 1 ed., pp. 173-213). New York: Springer. DOI Scopus29 WoS26 Europe PMC10

Conference Papers

Year	Citation
2019	Groome, H. M., Care, A. S., Chin, P. Y., Roberts, C. T., & Robertson, S. A. (2019). Macrophage Regulation of Decidual Vascular Remodelling is Crucial for Pregnancy Success in Mice.. In REPRODUCTIVE SCIENCES Vol. 26 (pp. 202A). Paris, FRANCE: SAGE PUBLICATIONS INC.
2019	Kieffer, E. C., Chin, P. Y., Green, E. S., Moldenhauer, L. M., Prins, J. R., & Robertson, S. A. (2019). Prednisolone Treatment in Early Pregnancy Disrupts Maternal Immune Adaptation and Alters Pregnancy Outcomes in Mice.. In REPRODUCTIVE SCIENCES Vol. 26 (pp. 291A-292A). Paris, FRANCE: SAGE PUBLICATIONS INC.
2016	Green, E., Moldenhauer, L. M., Kara, E. E., Chin, P. Y., Robker, R. L., McColl, S. R., & Robertson, S. A. (2016). Progesterone control of regulatory T cell phenotype and abundance in pregnancy - A novel role for non-classical progesterone action. In JOURNAL OF REPRODUCTIVE IMMUNOLOGY Vol. 115 (pp. 43). Erfurt, GERMANY: ELSEVIER IRELAND LTD. DOI
2011	Chin, P. Y., Thompson, J. G., & Robertson, S. A. (2011). Maternal Interleukin-10 Deficiency Increases Sensitivity to Adverse Programming Effects of a Low Dose LPS Insult in the Pre-Implantation Period.. In BIOLOGY OF REPRODUCTION Vol. 85 (pp. 2 pages). Portland, OR: SOC STUDY REPRODUCTION.
2010	Chin, P. Y., Thompson, J. G., & Robertson, S. A. (2010). Programming embryo development with a pre-implantation inflammatory insult. In JOURNAL OF REPRODUCTIVE IMMUNOLOGY Vol. 86 (pp. 39). Palm Grove, AUSTRALIA: ELSEVIER IRELAND LTD. DOI WoS1

Conference Items

Year	Citation
2017	Nadeau-Vallee, M., Chin, P. -Y., Belarbi, L., Brien, M. -E., Pundir, S., Beaudry-Richard, A., . . . Chemtob, S. (2017). Antenatal Suppression of Interleukin-1 Protects Against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice.. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Orlando, FL: SAGE PUBLICATIONS INC.
2017	Nadeau-Vallee, M., Chin, P. -Y., Belarbi, L., Brien, M. -E., Pundir, S., Berryer, M. H., . . . Chemtob, S. (2017). PROTECTIVE EFFECT OF A NOVEL NONCOMPETITIVE IL-1 RECEPTOR-BIASED LIGAND IN AN INFECTION-AND INFLAMMATION-INDUCED PRETERM BIRTH AS WELL AS IN FETAL INJURY AND DEVELOPMENTAL OUTCOMES. Poster session presented at the meeting of ACTA PAEDIATRICA. WILEY.
2016	Green, E. S., Moldenhauer, L. M., Kara, E. E., Chin, P. Y., Robker, R. L., McColl, S. R., & Robertson, S. A. (2016). Regulatory T cell abundance and phenotype in pregnancy - a novel role for progesterone potentially independent of nuclear progesterone receptor. Poster session presented at the meeting of EUROPEAN JOURNAL OF IMMUNOLOGY. Melbourne, AUSTRALIA: WILEY-BLACKWELL.
2014	Robertson, S. A., Gomez-Lopez, N., Diener, K., Bijland, M. T., Chin, P. -Y., & Olson, D. M. (2014). Essential Role for Macrophages in Late Gestation Pregnancy to Prevent Spontaneous Preterm Birth in Mice. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.
2014	Robertson, S. A., Chin, P. -Y., Dorian, C., & Hutchinson, M. (2014). Inhibition of the TLR4 Signalling Pathway Protects Mice from LPS-Induced Preterm Delivery. Poster session presented at the meeting of REPRODUCTIVE SCIENCES. Florence, ITALY: SAGE PUBLICATIONS INC.

Figures

Year	Citation
	Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Toll-like receptor-4 antagonist (+)-naloxone elicits sexually dimorphic attenuation of inflammation-induced fetal programming in mice. Supplemental Figure 1. DOI
	Chin, L., Dorian, C., Hutchinson, M., & Robertson, S. (n.d.). Effect of Toll-like receptor-4 antagonist (+)-naloxone and LPS challenge on gestation length, litter size and early post-natal survival and growth.. DOI

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2022	Co-Supervisor	The overarching aim of my research project is to investigate the impact of viral-induced inflammation around the time of conception on fetal and offspring immune programming and to identify if the offspring are more susceptible to auto-inflammatory conditions in later life	Doctor of Philosophy	Doctorate	Full Time	Miss Stacey Jasmin Savin

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2017 - 2021	Co-Supervisor	The role of macrophages in vascular adaptation to pregnancy in mice	Doctor of Philosophy	Doctorate	Full Time	Miss Holly Michelle Groome

Position: NHMRC Postdoctoral Research Officer (A)
Phone: 83137715
Email: loretta.chin@adelaide.edu.au
Campus: North Terrace
Building: Adelaide Health and Medical Sciences, floor 6
Org Unit: Medical Sciences

Dr Loretta Chin

Appointments

Language Competencies

Education