Postdoctoral Research Fellow
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
Dr Liza Phillips (MBBS (Hons), FRACP, PhD, MS (Epi)), is a consultant endocrinologist and post-doctoral research fellow at the Royal Adelaide Hospital and a Clinical Lecturer at the University of Adelaide. She has clinical interests in diabetes, pituitary disease and inborn errors of metabolism in adults and is the deputy director of physician education at the Royal Adelaide Hospital. She is an early career researcher with an interest in the epidemiology and physiology of type 2 diabetes, in particular, the interaction between the gut and glycaemia and the impact of glycaemic control/diabetes in critical care.
Research Project 1
Title: Effects of acute and sub-acute treatment with metformin on cardiovascular responses to a glucose challenge in type 2 diabetes
Project description: Type 2 diabetes (T2DM) is associated with a two-fold increased risk of cardiovascular disease, and despite targeted lifestyle and pharmacologic strategies that modify risk factors, myocardial infarction remains the leading cause of death in this population.
Improvements in glycaemic control have only a modest effect to optimise cardiovascular outcomes in contrast to their profound effect to diminish the risk of development and progression of microvascular disease. Moreover, studies with metformin, an established first-line medication for T2DM, and more recently, agents from the sodium glucose linked transporter 2 (SGLT-2) inhibitor and glucagon-like peptide-1 (GLP-1) agonist classes, have highlighted the importance of ‘non-glycaemia’ driven mechanisms, translating into impressive reductions in cardiovascular disease in T2DM.
Postprandial hyperglycaemia is an independent cardiovascular risk factor, makes a major contribution to overall glycaemic control as determined by HbA1c and thus is an important therapeutic target. Our recent work has established that metformin, at least in the acute setting, modulates cardiovascular responses, including blood pressure (BP) and heart rate (HR), to enteral nutrients in patients with T2DM. In this study we will investigate the acute and sub-acute effects of metformin on the cardiovascular responses to a 75g glucose challenge in T2DM.
Projects available for:list as appropriate
Honours / HDR / Masters
AHMS (Adelaide Health & Medical Sciences Building, North Tce)
Research project start:
Semester 1 and 2
Date Position Institution name 2014 Deputy Director of Physician Training Royal Adelaide Hospital 2014 Postdoctoral Research Fellow University of Adelaide 2014 Endocrinologist Royal Adelaide Hospital
Date Title Institution Country — PhD University of Queensland Australia — FRACP Royal Australasian College of Physicians Australia — Masters of Science in Epidemiology Columbia University United States
Date Title Institution name Country 2000 MBBS (Hons) University of Adelaide Australia
Year Citation 2019 Watson, L. E., Phillips, L., Wu, T., Bound, M., Checklin, H. L., Grivell, J., . . . Rayner, C. (2019). A whey/guar “preload” improves postprandial glycaemia and glycated haemoglobin levels in type 2 diabetes: a 12-week, single-blind, randomized, placebo-controlled trial. Diabetes, Obesity and Metabolism, 21(4), 930-938.
DOI Scopus2 WoS2 Europe PMC1
2019 Kar, P., Plummer, M., Ali Abdelhamid, Y., Giersch, E., Summers, M., Weinel, L., . . . Deane, A. (2019). Incident Diabetes in Survivors of Critical Illness and Mechanisms Underlying Persistent Glucose Intolerance: A Prospective Cohort Study. Critical care medicine, 47(2), 103-111.
DOI Scopus1 WoS1
2019 Watson, L., Xie, C., Wang, X., Li, Z., Phillips, L., Sun, Z., . . . Wu, T. (2019). Gastric emptying in patients with well-controlled type 2 diabetes compared with young and older control subjects without diabetes. Journal of Clinical Endocrinology and Metabolism, 104(8), 3311-3319.
DOI Scopus1 WoS1
2019 Watson, L. E., Phillips, L. K., Wu, T., Bound, M. J., Jones, K. L., Horowitz, M., & Rayner, C. K. (2019). Longitudinal evaluation of gastric emptying in type 2 diabetes. Diabetes Research and Clinical Practice, 154, 27-34.
2019 Pham, H., Phillips, L., & Jones, K. (2019). Acute Effects of Nutritive and Non-Nutritive Sweeteners on Postprandial Blood Pressure. Nutrients, 11(8), 29 pages.
2019 Pham, H., Phillips, L., Marathe, C., Trahair, L., Hatzinikolas, S., Huynh, L., . . . Jones, K. (2019). Longitudinal changes in fasting and glucose-stimulated GIP and GLP-1 in healthy older subjects. DIABETOLOGIA, 62, S128-S129.
2019 Riceman, M., Bound, M., Grivell, J., Hatzinikolas, S., Piotto, S., Nguyen, N., . . . Phillips, L. (2019). The prevalence and impact of low faecal elastase-1 in community-based patients with type 2 diabetes. Diabetes Research and Clinical Practice, 156, 107822.
2019 Pham, H., Phillips, L., Trahair, L., Hatzinikolas, S., Horowitz, M., & Jones, K. L. (2019). Longitudinal changes in the blood pressure responses to, and gastric emptying of, an oral glucose load in healthy older subjects. The journals of gerontology. Series A, Biological sciences and medical sciences, 5 pages.
DOI Europe PMC1
2019 Pham, H., Trahair, L., Phillips, L., Rayner, C., Horowitz, M., & Jones, K. (2019). A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults. BMC Geriatrics, 19(1), 241.
2018 Pham, H., Stevens, J., Rigda, R., Phillips, L., Wu, T., Hausken, T., . . . Jones, K. (2018). Effects of intraduodenal administration of the artificial sweetener sucralose on blood pressure and superior mesenteric artery blood flow in healthy older subjects. American Journal of Clinical Nutrition, 108(1), 156-162.
DOI WoS1 Europe PMC1
2018 Watson, L., Phillips, L., Wu, T., Bound, M., Checklin, H., Grivell, J., . . . Rayner, C. (2018). Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes. Clinical Nutrition.
DOI Scopus2 Europe PMC1
2018 Nguyen, T., Ali Abdelhamid, Y., Weinel, L., Hatzinikolas, S., Kar, P., Summers, M., . . . Deane, A. (2018). Postprandial hypotension in older survivors of critical illness. Journal of Critical Care, 45, 20-26.
DOI Scopus1 WoS2 Europe PMC1
2018 Crowther, S., Rushworth, R., Rankin, W., Falhammar, H., Phillips, L., & Torpy, D. (2018). Trends in surgery, hospital admissions and imaging for pituitary adenomas in Australia. Endocrine, 59(2), 373-382.
DOI Scopus1 WoS1 Europe PMC1
2017 Abdelhamid, Y., Plummer, M., Finnis, M., Biradar, V., Bihari, S., Kar, P., . . . Deane, A. (2017). Long-term mortality of critically ill patients with diabetes who survive admission to the intensive care unit. Critical Care and Resuscitation, 19(4), 303-309.
Scopus1 WoS1 Europe PMC1
2017 Nguyen, T. A., Abdelhamid, Y. A., Phillips, L. K., Chapple, L. S., Horowitz, M., Jones, K. L., & Deane, A. M. (2017). Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients.. World journal of critical care medicine, 6(1), 28-36.
2016 Ali Abdelhamid, Y., Phillips, L., Horowitz, M., & Deane, A. (2016). Survivors of intensive care with type 2 diabetes and the effect of shared care follow-up clinics: study protocol for the SWEET-AS randomised controlled feasibility study. Pilot and Feasibility Studies, 2(1), 1-10.
2016 Sivakumar, S., Taccone, F., Desai, K., Lazaridis, C., Skarzynski, M., Sekhon, M., . . . Azevedo, L. (2016). ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016.. Intensive care medicine experimental, 4(Suppl 1), 30.
2016 Ali Abdelhamid, Y., Kar, P., Finnis, M., Phillips, L., Plummer, M., Shaw, J., . . . Deane, A. (2016). Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis.. Critical Care, 20(1), 301.
DOI Scopus18 WoS17 Europe PMC9
2016 Plummer, M., Finnis, M., Phillips, L., Kar, P., Bihari, S., Biradar, V., . . . Deane, A. (2016). Stress induced hyperglycemia and the subsequent risk of type 2 diabetes in survivors of critical illness. PLoS One, 11(11), e0165923-12.
DOI Scopus6 WoS9 Europe PMC2
2015 Phillips, L., Deane, A., Jones, K., Rayner, C., & Horowitz, M. (2015). Gastric emptying and glycaemia in health and diabetes mellitus. Nature Reviews Endocrinology, 11(2), 112-128.
DOI Scopus83 WoS77 Europe PMC47
2014 Phillips, L., Rayner, C., Jones, K., & Horowitz, M. (2014). Measurement of gastric emptying in diabetes. Journal of Diabetes and Its Complications, 28(6), 894-903.
DOI Scopus21 WoS19 Europe PMC11
2008 Stevens, J., Russo, A., Maddox, A., Rayner, C., Phillips, L., Talley, N., . . . Jones, K. (2008). Effect of itopride on gastric emptying in longstanding diabetes mellitus. Neurogastroenterology and Motility, 20(5), 456-463.
DOI Scopus29 WoS19 Europe PMC16
2007 Yong, T., Phillips, L., Horowitz, M., & Giles, N. (2007). Severe hypoglycaemic unawareness in a patient with insulinoma. Internal Medicine Journal, 37(2), 141-142.
DOI Scopus3 WoS4 Europe PMC3
2006 Little, T., Pilichiewicz, A., Russo, A., Phillips, L., Jones, K., Nauck, M., . . . Feinle-Bisset, C. (2006). Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: Relationships with postprandial glycemic and insulinemic responses. Journal of Clinical Endocrinology and Metabolism, 91(5), 1916-1923.
DOI Scopus117 WoS114 Europe PMC89
2006 Phillips, L., & Horowitz, M. (2006). Amylin. Current Opinion in Endocrinology, Diabetes and Obesity, 13(2), 191-198.
2006 Phillips, L., Rayner, C., Jones, K., & Horowitz, M. (2006). An update on autonomic neuropathy affecting the gastrointestinal tract. Current Diabetes Reports, 6(6), 417-423.
DOI Scopus22 Europe PMC18
2006 Phillips, L., & Phillips, P. (2006). Innovative insulins: Where do analogues fit?. Australian Family Physician, 35(12), 969-973.
Year Citation 2018 Shen, A., Torpy, H. M., Phillips, L. K., King, J., Torpy, D., Yates, C., & Colman, P. (2018). Clinical characterization of patients with Cushing's disease from two Australian tertiary hospitals. In CLINICAL ENDOCRINOLOGY Vol. 89 (pp. 50-51). Perth, AUSTRALIA: WILEY. 2018 Rayner, C., Watson, L., Phillips, L., Bound, M., Grivell, J., Wu, T., . . . Natali, A. (2018). Effects of sustained treatment with lixisenatide on gastric emptying and glucose metabolism in type 2 diabetes. In DIABETOLOGIA Vol. 61 (pp. S386-S387). Berlin, GERMANY: SPRINGER. 2005 Phillips, L., Little, T., Pilichiewicz, A., Russo, A., Jones, K., Nauck, M., . . . Feinle-Bisset, C. (2005). The suppression of postprandial glycaemia by glucagon-like peptide I in healthy subjects is closely related to slowing of gastric emptying. In DIABETOLOGIA Vol. 48 (pp. A201-A202). Athens, GREECE: SPRINGER.
2019 Phillips L. The RAH Gum Bequest (HSCGB) salary support ($40, 000)
2019 Phillips L, Wu T, Rayner C, Jones KL, Horowitz M. The Royal Adelaide Hospital Clinical Project Grant: Effects of acute and sub-acute treatment with metformin on cardiovascular responses to a glucose challenge in type 2 diabetes ($49,998)
2019 KL Jones, L Phillips, T Wu, C Marathe, M Horowitz, C Rayner – Diabetes Australia Research Trust General Grant: Effect of exenatide once weekly on gastric emptying of, and the postprandial glycaemic and cardiovascular responses to, an oral glucose load in type 2 diabetes. ($59,872)
2019 KL Jones, L Phillips, C Rayner, T Wu, M Horowitz - Royal Adelaide Hospital Research Foundation - Clinical Project Grant: Effect of exenatide BID on small intestinal transit, absorption, glycaemia and blood pressure in type 2 diabetes. ($49,859)
2017 KL Jones, L Phillips, C Rayner, A Deane. University of Adelaide, School of Medicine - RIBG Equipment Grant: Mechanisms and management of postprandial hypotension. ($7200)
2017 L Phillips, C Rayner, N Nguyen, KL Jones, M Horowitz; Diabetes Australia Research Trust: Impact of pancreatic exocrine insufficiency and pancreatic enzyme replacement therapy on gastric emptying, gut hormone, and glycaemic responses to a meal in type 2 diabetes. ($60,023)
2017 Y Ali Abdelhamid, KL Jones, M Horowitz, P Kar, L Phillips, T Nguyen, A Deane; - Royal Adelaide Hospital Research Foundation – Clinical Project Grant: Prevalence, mechanisms and impact of postprandial hypotension in elderly survivors of critical illness. ($49,208)
2017 KL Jones, T Kimber, L Phillips, C Rayner. Royal Adelaide Hospital Research Foundation – Clinical Project Grant: Acute effects of dopaminergic therapy with levodopa/carbidopa on the gastric emptying, blood pressure and superior mesenteric artery blood flow responses to oral glucose in patients with mild to moderate Parkinson’s disease. ($30,000)
2016-2018 Phillips L. The Royal Adelaide Hospital Research Foundation Early Career Fellowship ($126,000)
2016 Phillips L. The Gum bequest (HSCGB) RAH salary and project support: 1) Pituitary disease in Australia and 2) The influence of the gut-incretin axis on glycaemia in Type 2 diabetes ($17, 400)
2016 Phillips L The Gum bequest (HSCGB) RAH equipment grant: ANSAR; autonomic function package, ECG and analytic system ($34,500)
2016 Phillips L, Horowitz M, Rayner C, Jones K. The Royal Adelaide Hospital Research Foundation Clinical Project Grant Does rapid gastric emptying increase the risk of type 2 diabetes ($50,113)
2016 Phillips L. RACP Diabetes Australia Research Establishment Fellowship 2016 The relationship between gut and glycaemia in type 2 diabetes ($50,000)
2015 Phillips L, Horowitz M, Shaw J, Deane A, Plummer M Diabetes Australia – General Grant: Glycaemia in the critically ill ($59, 915)
2015 Chapman I, Phillips L, Torpy D. The Royal Adelaide Hospital Research Foundation Clinical Project Grant Cushing's disease: Understanding the long-term morbidity and mortality in the context of control and relapse. ($39, 990)
2013 Phillips L The Servier Staff Research Fellowship, Royal Australasian College of Physicians Masters of Science in Epidemiology, Mailman School of Public Health, Columbia, NY USA ($10, 000)
2009 Phillips L Glaxo Smith Kline Postgraduate Support Grant Adiponectin- role in modulating postprandial inflammatory, oxidative and cardiovascular stress ($25,000)
2008 Phillips L Princess Alexandra Research Foundation Training Grant Adiponectin- role in modulating postprandial inflammatory, oxidative and cardiovascular stress ($20, 000)
2007 Phillips L NHMRC John Shaw Scholarship Adiponectin- role in modulating postprandial inflammatory, oxidative and cardiovascular stress ($107,100)
2007 Phillips L Basser Research Entry Scholarship, Royal Australian College of Physicians ($29, 000) (not taken up due to NHMRC award)
Clinical lecturer for University of Adelaide: lecture undergraduates (diabetes and complications, osteoporosis); OSCE examination; written examination questions; review PBL content
MD Endocrine Module Development
Teaching on the Run workshop, RAH
Teaching and Learning in Healthcare Settings, RACP
RACP local examiner
Local and State clinical trial examination and Long Case Programme
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2016 Co-Supervisor Mechanisms and management of postprandial hypotension Doctor of Philosophy Doctorate Full Time Mr Hung Thai Pham 2015 Co-Supervisor Long-Term Outcome in Survivors of Critical Illness and Interaction with Glucose Metabolism Doctor of Philosophy Doctorate Full Time Dr Yasmine Ali Abdelhamid
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