Dr Linh Dang
School of Medicine
College of Health
Dr. Linh Dang joined the Lysosomal Health in Ageing under Associate Professor Tim Sargeant at SAHMRI in 2022. She became affiliated with the Adelaide Medical School, Faculty of Health and Medical Sciences, at The University of Adelaide in 2025. Dr. Dang completed her PhD in Immunology at Karolinska Institute, Stockholm, Sweden. Her research focuses on assessing autophagic flux in primary cells and developing autophagic flux assays for blood samples. She also investigates the effects of nutritional and pharmacological factors on autophagy in primary cells and their related outcomes. Currently, she is studying the role of autophagy in T lymphocyte differentiation, with a particular emphasis on generating stem cell-like memory T cells.
My current research under Associate Professor Tim Sargeant focuses on measuring autophagy in humans during aging through blood tests and biomarkers to determine whether changes in autophagy are associated with aging and whether autophagy levels can be modulated pharmacologically or nutritionally. We have successfully developed a method to measure autophagic flux in individual cell populations in blood, which is protected under the provisional patent Methods and Products for Assessing Autophagic Flux (Sargeant T, Dang L; Australian Provisional Patent 2024900604, PCT/AU2025/050203).
Additionally, I am investigating autophagy levels in immune cells, including T lymphocytes and monocytes, with a particular focus on the role of autophagy in T cell differentiation. This research emphasizes the dual roles of mTOR and autophagy in T cell activation and differentiation, as well as exploring the use of autophagy inducers to promote the generation of stem cell-like memory T cells.
| Language | Competency |
|---|---|
| English | Can read, write, speak, understand spoken and peer review |
| Vietnamese | Can read, write, speak, understand spoken and peer review |
| Date | Institution name | Country | Title |
|---|---|---|---|
| Karolinska Institute | Sweden | PhD | |
| University of Sydney | Australia | Bachelor |
| Year | Citation |
|---|---|
| 2025 | Singh, S., Carosi, J. M., Dang, L., & Sargeant, T. J. (2025). Autophagy does not always decline with ageing. Nature Cell Biology, 27(5), 712-715. Scopus2 WoS2 Europe PMC2 |
| 2025 | Bensalem, J., Teong, X. T., Hattersley, K. J., Hein, L. K., Fourrier, C., Dang, L. V. P., . . . Sargeant, T. J. (2025). Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis.. Journal of Physiology, 603(10), 3019-3032. Scopus5 WoS4 Europe PMC4 |
| 2025 | Dang, L. V. P., Martin, A., Carosi, J. M., Gore, J., Singh, S., & Sargeant, T. J. (2025). Cell-Type-Specific Autophagy in Human Leukocytes. The FASEB Journal, 39(12), e70708-1-e70708-13. Scopus4 WoS2 Europe PMC2 |
| 2025 | Singh, S., Fourrier, C., Hattersley, K. J., Hein, L. K., Gore, J., Martin, A., . . . Sargeant, T. J. (2025). High protein does not change autophagy in human peripheral blood mononuclear cells after one hour. JCI Insight, 10(16), e188845-1-e188845-3. |
| 2025 | Dang, L. V., & Sargeant, T. J. (2025). Cell type-specific autophagy in human leukocytes: signatures of aging, sex, and nutrient restriction.. Autophagy Rep, 4(1), 2543560. Scopus1 Europe PMC1 |
| 2024 | Carosi, J. M., Hein, L. K., Sandow, J. J., Dang, L. V. P., Hattersley, K., Denton, D., . . . Sargeant, T. J. (2024). Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling. Autophagy, 20(4), 863-882. Scopus8 WoS8 Europe PMC10 |
| 2023 | Nguyen, M. D., Van Tran, T., Nguyen, Q. V., Ha, C. D., & Dang, L. V. P. (2023). Effectiveness of bee venom acupuncture for patients suffering from periarthritis humeroscapularis. Journal of Traditional Chinese Medicine, 43(4), 795-800. Scopus5 WoS7 Europe PMC3 |
| 2023 | Nguyen, M. D., Van Tran, T., Vinh Nguyen, Q., Nguyen, N. K., Vu, S. T., Nguyen, L. T., & Dang, L. V. P. (2023). Effectiveness on post-stroke hemiplegia in patients: electroacupuncture plus cycling vs electroacupuncture alone. Journal of Traditional Chinese Medicine, 43(2), 352-358. Scopus10 WoS3 Europe PMC6 |
| 2021 | Nguyen, M. D., Nguyen, Q. V., Ha, C. D., Van Tran, T., & Dang, L. V. P. (2021). Beneficial Effects of Acupuncture as a Complementary Treatment for Patients Receiving Paroxetine for Major Depressive Disorder: A Meta-Analysis. Medical Acupuncture, 33(6), 420-427. Scopus1 WoS1 |
| 2021 | Duong, H. Q., Than, V. T., Nguyen, H. T., Nguyen, P. T., Thi, H. T. H., Bui, T. N. H., . . . Seong, Y. S. (2021). Anaplastic lymphoma kinase inhibitor NVP-TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells. Oncology Reports, 45(4), 28. Scopus7 Europe PMC7 |
| 2021 | Tran, T. V., Tran, T. D., Nguyen, A. Q., Dinh, T. T., Le, A. T. K., Tran, H. B., . . . Dang, L. V. P. (2021). Nurse–patient communication: A quality assessment in public hospital. International Journal of Healthcare Management, 14(4), 1127-1133. Scopus7 |
| 2020 | Dang, L. V. P., Pham, H. V., Dinh, T. T., Vu, P. T., Nguyen, L. V., Le, H. T., . . . Olson, L. (2020). Molecular genotypes of gag sequences in HIV-1 infected children treated with antiretroviral therapy in Vietnam. Therapeutic Advances in Infectious Disease, 7, 10 pages. |
| 2020 | Dang, L. V. P., Pham, H. V., Dinh, T. T., Nguyen, T. H., Vu, Q. T. H., Vu, N. T. P., . . . Olson, L. (2020). Characterization of envelope sequence of HIV virus in children infected with HIV in Vietnam. Sage Open Medicine, 8, 8 pages. Scopus4 WoS4 Europe PMC3 |
| 2020 | Dang, L. V. P., Nguyen, Q. H., Ishizaki, A., Larsson, M., Vu, N. T. P., Do Duy, C., . . . Dinh, T. T. (2020). Prevalence of Opportunistic Infections and Associated Factors in HIV-Infected Men Who Have Sex With Men on Antiretroviral Therapy in Bach Mai Hospital, Hanoi, Vietnam: A Case-Control Study. American Journal of Men S Health, 14(3), 12 pages. Scopus6 WoS7 Europe PMC8 |
| 2019 | Pham, T., Bui, L., Nguyen, A., Nguyen, B., Tran, P., Vu, P., & Dang, L. (2019). The prevalence of depression and associated risk factors among medical students: An untold story in Vietnam. Plos One, 14(8), 17 pages. Scopus88 WoS85 Europe PMC63 |
| 2019 | Dang, V. P. L., Pham, V. H., Dinh, T. T., Le, T. H., Nguyen, V. L., & Vu, T. P. (2019). Growth in children infected with HIV receiving anti-retroviral therapy in Vietnam. Pediatrics International, 61(4), 369-374. Scopus1 WoS1 Europe PMC1 |
| 2018 | Dang, L. V. P., Pham, V. H., Nguyen, D. M., Dinh, T. T., Nguyen, T. H., Le, T. H., . . . Vu, T. P. (2018). Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam. HIV AIDS Research and Palliative Care, 11, 1-7. Scopus3 WoS4 Europe PMC2 |
| 2017 | Dang, M. D., Nguyen, D. M., Tran, H. B., Pham, V. H., Spak, D., Pham, L. C., . . . Dang, V. P. L. (2017). Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study. International Journal of Public Health, 62(Suppl 1), 113-119. Scopus3 WoS3 Europe PMC3 |
| 2012 | Dang, L. V. P., Nilsson, A., Ingelman-Sundberg, H., Cagigi, A., Gelinck, L. B. S., Titanji, K., . . . Chiodi, F. (2012). Soluble CD27 induces IgG production through activation of antigen-primed B cells. Journal of Internal Medicine, 271(3), 282-293. Scopus24 WoS25 Europe PMC23 |
| 2011 | Sammicheli, S., Linh, D. V. P., Ruffin, N., Thang, P. H., Lantto, R., Vivar, N., . . . Rethi, B. (2011). IL-7 Promotes CD95-Induced Apoptosis in B Cells via the IFN-γ/STAT1 Pathway. PLOS ONE, 6(12), 10 pages. WoS15 |
| 2009 | Cagigi, A., Du, L., Dang, L. V. P., Grutzmeier, S., Atlas, A., Chiodi, F., . . . Nilsson, A. (2009). CD27- B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection. Plos One, 4(5), 9 pages. Scopus50 WoS49 Europe PMC46 |
| 2008 | Cagigi, A., Mowafi, F., Dang, L. V. P., Tenner-Racz, K., Atlas, A., Grutzmeier, S., . . . Nilsson, A. (2008). Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood, 112(12), 4401-4410. Scopus71 WoS70 Europe PMC60 |
| Year | Citation |
|---|---|
| 2024 | Dang, L. V. P., Martin, A., Carosi, J., Gore, J., Singh, S., & Sargeant, T. (2024). Cell-type specific autophagy in human leukocytes. DOI |
- Imaging lysosomal function in the brain. NHMRC, 2023/GNT2027655 (Associated Investigator)
- The association between immunological, molecular biology markers and increased prevalence of opportunistic infection in HIV infected MSM (men who have sex with men) in Vietnam (Funded by TRAC, Training and Research Academic Collaboration Sweden-Vietnam, seed funding)
- Investigate the alterations of immune activation markers and the appearance immune-escape mutations of HIV virus in HIV infected children treated with Anti-retroviral therapy ART (Role: PI, Funded by Nafosted, Ministry of Science and Technology, Vietnam, 2015-2018)
- The role of clinical markers in prognosis of treatment response in HIV-infected children treated with Anti-retroviral Therapy (ART) (Role: PI, Funded by Hanoi University of Public Health, Vietnam, 2014-2015)
Lecturer at Hanoi University of Public Health
- Developing/participating in developing training modules for Bachelor of Medical Technician
- Teaching basic medical science subjects: Basic Laboratory, Basic Laboratory technique, Clinical Immunological technique, HIV laboratory testing, Clinical Molecular Biology, Immunology, and Pathophysiology
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