Dr Linda Shearwin
ARC Grant-Funded Researcher (B)
School of Biological Sciences
Faculty of Sciences, Engineering and Technology
Eligible to supervise Masters and PhD - email supervisor to discuss availability.
My research career has focussed on the identification of genes and their functional characterisation using bioinformatic, molecular and synthetic biology techniques. I have also spent four years teaching and developing curriculum for the Masters in Biotechnology, Biomedical course from the inception of this program in the School of Biological Sciences (2012-2015). Currently in the Laboratory of Comparative Genome Biology, Department of Molecular and Biomedical Science, my research centres on the molecular analysis of monotremes, egg-laying mammals which diverged 166 million years ago from other mammals. The platypus and echidna are the only living representatives of this group and as such provide a unique system in which to study mammalian evolution. Research in the Laboratory of Comparative Genome Biology, led by Prof. Frank Grützner, has shown that monotremes have a unique sex determination system not found in other mammals. I am studying the chromosomes and candidate genes which control sex determination in these iconic Australian mammals.
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Journals
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Conference Papers
Year Citation 2019 Shearwin-Whyatt, L. M., Nguyen, N. M. H., Zhou, Q., Zhang, G., & Grützner, F. (2019). Analysis of novel Y-specific genes in monotremes. In 6th Australian Sex Summit. Lancefield, Victoria. 2002 Korbmacher, C., Konstas, A. A., Shearwin-Whyatt, L. M., Fotia, A. B., Degger, B., Riccardi, D., . . . Kumar, S. (2002). The epithelial sodium channel (ENaC) is regulated by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.. In JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 13 (pp. 21A-22A). AMER SOC NEPHROLOGY. 1998 Rathjen, P. D., Lake, J., Whyatt, L. M., Bettess, M. D., & Rathjen, J. (1998). Properties and uses of embryonic stem cells: Prospects for application to human biology and gene therapy. In Reproduction, Fertility and Development Vol. 10 (pp. 31-47). ADELAIDE, AUSTRALIA: C S I R O PUBLICATIONS.
DOI Scopus88 WoS77 Europe PMC44 -
Preprint
Year Citation 2024 Dann, J., Qu, Z., Shearwin-Whyatt, L., van der Ploeg, R., & Grützner, F. (2024). Pseudogenisation of NK3 Homeobox 2 (<i>Nkx3.2</i>) in Monotremes Provides Insight into Unique Gastric Anatomy and Physiology.
DOI2024 Shearwin-Whyatt, L., Fenelon, J., Yu, H., Major, A., Qu, Z., Zhou, Y., . . . Grützner, F. (2024). AMHY and sex determination in egg-laying mammals.
DOI2023 Lister, N., Milton, A., Patel, H., Waters, S., Hanrahan, B., McIntyre, K., . . . Waters, P. (2023). Incomplete transcriptional dosage compensation of vertebrate sex chromosomes is balanced by post-transcriptional compensation.
DOI
I currently co-supervise an Honours student and a Doctor of Philosophy Student.
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Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2023 Co-Supervisor Investigating the sex determining genes and the evolution of sex chromosomes in Monotremes Master of Philosophy Master Full Time Miss Rachel Emily van der Ploeg -
Past Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2018 - 2022 Co-Supervisor Evolution and Organization of Monotreme Sex Chromosomes Doctor of Philosophy Doctorate Full Time Mr Filip Pajpach
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