Dr Linda Shearwin

ARC Grant-Funded Researcher (B)

School of Biological Sciences

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

My Research
Publications
Teaching
Supervision
Contact

My research career has focussed on the identification of genes and their functional characterisation using bioinformatic, molecular and synthetic biology techniques. I have also spent four years teaching and developing curriculum for the Masters in Biotechnology, Biomedical course from the inception of this program in the School of Biological Sciences (2012-2015). Currently in the Laboratory of Comparative Genome Biology, Department of Molecular and Biomedical Science, my research centres on the molecular analysis of monotremes, egg-laying mammals which diverged 166 million years ago from other mammals. The platypus and echidna are the only living representatives of this group and as such provide a unique system in which to study mammalian evolution. Research in the Laboratory of Comparative Genome Biology, led by Prof. Frank Grützner, has shown that monotremes have a unique sex determination system not found in other mammals. I am studying the chromosomes and candidate genes which control sex determination in these iconic Australian mammals.

Journals

Year	Citation
2024	Dann, J., Qu, Z., Shearwin-Whyatt, L., van der Ploeg, R., & Grützner, F. (2024). Pseudogenization of NK3 homeobox 2 (Nkx3.2) in monotremes provides insight into unique gastric anatomy and physiology. Open Biology, 14(7), 240071-1-240071-8. DOI Europe PMC1
2024	Lister, N. C., Milton, A. M., Patel, H. R., Waters, S. A., Hanrahan, B. J., McIntyre, K. L., . . . Waters, P. D. (2024). Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation. Proceedings of the National Academy of Sciences of USA, 121(32), e2322360121-1-e2322360121-7. DOI Europe PMC2
2024	Takii, R., Fujimoto, M., Pandey, A., Jaiswal, K., Shearwin-Whyatt, L., Grutzner, F., & Nakai, A. (2024). HSF1 is required for cellular adaptation to daily temperature fluctuations. Scientific Reports, 14(1), 21361. DOI
2021	Liu, S., Zhao, Y., Hayes, A., Hon, K., Zhang, G., Bennett, C., . . . Vreugde, S. (2021). Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat sub-inhibitory concentrations. Allergy, 76(11), 3446-3458. DOI Scopus12 WoS5 Europe PMC7
2021	Pajpach, F., Wu, T., Shearwin, L., Jones, K., & Grutzner, F. (2021). Flavors of non-random meiotic segregation of autosomes and sex chromosomes. Genes, 12(9), 1338-1-1338-22. DOI Scopus5 WoS3 Europe PMC5
2021	Pajpach, F., Shearwin-Whyatt, L., & Grutzner, F. (2021). Evolution, expression and meiotic behavior of genes involved in chromosome segregation of monotremes. Genes, 12(9), 1-17. DOI Scopus1
2021	Zhou, Y., Shearwin-Whyatt, L., Li, J., Song, Z., Hayakawa, T., Stevens, D., . . . Zhang, G. (2021). Platypus and echidna genomes reveal mammalian biology and evolution. Nature, 592(7856), 756-762. DOI Scopus88 WoS55 Europe PMC64
2019	Truong, J. Q., Panjikar, S., Shearwin-Whyatt, L., Bruning, J. B., & Shearwin, K. E. (2019). Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68. Acta crystallographica Section D. Structural biology, 75(7), 670-681. DOI Scopus3 WoS3 Europe PMC2
2008	Foot, N., Dalton, H., Shearwin-Whyatt, L., Dorstyn, L., Tan, S., Yang, B., & Kumar, S. (2008). Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood, 112(10), 4268-4275. DOI Scopus118 WoS107 Europe PMC93
2006	Shearwin-Whyatt, L., Dalton, H., Foot, N., & Kumar, S. (2006). Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays, 28(6), 617-628. DOI Scopus139 WoS130 Europe PMC112
2004	Shearwin-Whyatt, L., Brown, D., Wylie, F., Stow, J., & Kumar, S. (2004). N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. Journal of Cell Science, 117(16), 3679-3689. DOI Scopus62 WoS58 Europe PMC53
2002	Konstas, A., Shearwin-Whyatt, L., Fotia, A., Degger, B., Riccardi, D., Cook, D., . . . Kumar, S. (2002). Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. Journal of Biological Chemistry, 277(33), 29406-29416. DOI Scopus84 WoS82 Europe PMC63
2002	Harvey, K., Shearwin-Whyatt, L., Fotia, A., Parton, R., & Kumar, S. (2002). N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel golgi-associated protein. Journal of Biological Chemistry, 277(11), 9307-9317. DOI Scopus100 WoS98 Europe PMC88
2001	Shearwin-Whyatt, L., Baliga, B., Doumanis, J., & Kumar, S. (2001). Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells. Biochemical and Biophysical Research Communications, 282(5), 1114-1119. DOI Scopus5 WoS6 Europe PMC4
2001	Whyatt, L. M., & Rathjen, P. D. (2001). Interferon-inducible ES cell expression systems.. Methods in molecular biology (Clifton, N.J.), 158, 301-318. DOI Scopus1
2000	Shearwin-Whyatt, L., Harvey, N., & Kumar, S. (2000). Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death and Differentiation, 7(2), 155-165. DOI Scopus51 WoS47 Europe PMC38
1999	Haines, B., Rathjen, P., Hope, R., Whyatt, L., Holland, M., & Breed, W. (1999). Isolation and characterisation of a cDNA encoding a Zona Pellucida Protein (ZPB) from the marsupial Trichosurus vulpecula (Brushtail Possum). Molecular Reproduction and Development, 52(2), 174-182. DOI Scopus21 WoS22 Europe PMC10
1999	Shearwin-Whyatt, L., & Kumar, S. (1999). Caspases in developmental cell death. IUBMB Life, 48(2), 143-150. DOI Scopus4 WoS4 Europe PMC1
1999	Shearwin-Whyatt, L. M., & Kumar, S. (1999). Caspases in Developmental Cell Death. International Union of Biochemistry and Molecular Biology: Life, 48(2), 143-150. DOI
1998	Colussi, P., Harvey, N., Shearwin-Whyatt, L., & Kumar, S. (1998). Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 predomain. Journal of Biological Chemistry, 273(41), 26566-26570. DOI Scopus72 WoS70 Europe PMC49
1997	Whyatt, L. M., & Rathjen, P. D. (1997). Introduction of precise alterations into the mouse genome with high efficiency by stable tag-exchange gene targeting: Implications for gene targeting in ES cells. Nucleic Acids Research, 25(12), 2381-2388. DOI Scopus10 WoS8 Europe PMC3
1993	Whyatt, L. M., Düwel, A., Smith, A. G., & Rathjen, P. D. (1993). The responsiveness of embryonic stem cells to alpha and beta interferons provides the basis of an inducible expression system for analysis of developmental control genes. Molecular and Cellular Biology, 13(12), 7971-7976. DOI Scopus24 WoS23 Europe PMC17

Conference Papers

Year	Citation
2019	Shearwin-Whyatt, L. M., Nguyen, N. M. H., Zhou, Q., Zhang, G., & Grützner, F. (2019). Analysis of novel Y-specific genes in monotremes. In 6th Australian Sex Summit. Lancefield, Victoria.
2002	Korbmacher, C., Konstas, A. A., Shearwin-Whyatt, L. M., Fotia, A. B., Degger, B., Riccardi, D., . . . Kumar, S. (2002). The epithelial sodium channel (ENaC) is regulated by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.. In JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 13 (pp. 21A-22A). AMER SOC NEPHROLOGY.
1998	Rathjen, P. D., Lake, J., Whyatt, L. M., Bettess, M. D., & Rathjen, J. (1998). Properties and uses of embryonic stem cells: Prospects for application to human biology and gene therapy. In Reproduction, Fertility and Development Vol. 10 (pp. 31-47). ADELAIDE, AUSTRALIA: C S I R O PUBLICATIONS. DOI Scopus88 WoS77 Europe PMC44

Preprint

Year	Citation
2024	Dann, J., Qu, Z., Shearwin-Whyatt, L., van der Ploeg, R., & Grützner, F. (2024). Pseudogenisation of NK3 Homeobox 2 (<i>Nkx3.2</i>) in Monotremes Provides Insight into Unique Gastric Anatomy and Physiology. DOI
2024	Shearwin-Whyatt, L., Fenelon, J., Yu, H., Major, A., Qu, Z., Zhou, Y., . . . Grützner, F. (2024). AMHY and sex determination in egg-laying mammals. DOI
2023	Lister, N., Milton, A., Patel, H., Waters, S., Hanrahan, B., McIntyre, K., . . . Waters, P. (2023). Incomplete transcriptional dosage compensation of vertebrate sex chromosomes is balanced by post-transcriptional compensation. DOI

I currently co-supervise an Honours student and a Doctor of Philosophy Student.

Current Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2023	Co-Supervisor	Investigating the sex determining genes and the evolution of sex chromosomes in Monotremes	Master of Philosophy	Master	Full Time	Miss Rachel Emily van der Ploeg

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2018 - 2022	Co-Supervisor	Evolution and Organization of Monotreme Sex Chromosomes	Doctor of Philosophy	Doctorate	Full Time	Mr Filip Pajpach

Position: ARC Grant-Funded Researcher (B)
Phone: 83137513
Email: linda.shearwin@adelaide.edu.au
Fax: 83134362
Campus: North Terrace
Building: Molecular Life Sciences, floor 2
Org Unit: Molecular and Biomedical Science