Higher Degree by Research Candidate
School of Physical Sciences
Faculty of Sciences
Lauren graduated from a Bachelor of Science (Nanoscience and Naterials) in Chemistry at the University of Adelaide in 2016. She then went on to complete honours in organic chemistry at the University of Adelaide, where she worked at the interface of chemistry and biochemistry following a biomimetic synthetic pathway to synthesize a natural product analogue for the probing of intracellular targets. Lauren is currently undertaking a PhD in organic chemistry working with Assoc. Prof Jonathan George (University of Adelaide, Australia). Her thesis is primarily directed towards the biomimetic total synthesis of meroterpenoid natural products, to gain insight into their biosynthesis. Having access to these complex natural products as well as their proposed biosynthetic intermediates has enabled her to undertake chemoenzymatic studies at Scripps Institution of Oceanography (UC San Diego) with Professor Bradley Moore to discover two new enzymes! See publications for more details.
As a synthetic organic chemist, my research is focused on the biomimetic total synthesis of meroterpenoid natural products. This approach allows us to gain an understanding of how these complex molecules are synthesised in nature. Accessing these natural products as well as their intermediates then gives us the opportunity to further investigate their chemical biology and biosynthesis.
During my candidature I have completed the first ever synthesis of two meroterpenoid natural products, 7-demethylnaphterpin and debromomarinone, following a biomimetic synthetic approach. In collaboration with Prof. Bradley Moore (Scripps Institution of Oceanography, UCSD), I was then able to discover two new enzymes responsible for interconverting several of our chemically synthesised biosynthetic intermediates! (Angewandte, 2018)
More recently I have been working a divergent non-biomimetic synthesis towards more members of the naphterpin and marinone families, of which I have accessed 6 so far (Organic Letters, 2019).
My research interests span the fields of synthetic organic chemistry, natural products, biochemistry and biocatalysis.
Date Position Institution name 2016 Undergraduate Demonstrating University of Adelaide, Adelaide
Language Competency German Can read, speak and understand spoken
Date Institution name Country Title 2017 University of Adelaide, Adelaide Australia PhD Candidate 2016 - 2016 University of Adelaide, Adelaide Australia Bachelor of Science (Honours) 2013 - 2015 University of Adelaide, Adelaide Australia Bachelor of Science (Nanoscience and Materials)
Year Citation 2019 Murray, L. A., Fallon, T., Sumby, C. J., & George, J. H. (2019). Total synthesis of naphterpin and marinone natural products. Organic Letters, 21(20), 8312-8315.
DOI Scopus1 WoS1
2018 McKinnie, S., Miles, Z., Jordan, P., Awakawa, T., Pepper, H., Murray, L., . . . Moore, B. (2018). Total enzyme syntheses of napyradiomycins A1 and B1. Journal of the American Chemical Society, 140(51), 17840-17845.
DOI Scopus7 WoS5
2018 Murray, L., Mckinnie, S., Pepper, H., Erni, R., Miles, Z., Cruickshank, M., . . . George, J. (2018). Total synthesis establishes the biosynthetic pathway to the naphterpin and marinone natural products. Angewandte Chemie - International Edition, 57(34), 11009-11014.
DOI Scopus10 WoS9 Europe PMC1
2017 Marshall, A., Kroker, A., Murray, L., Gronthos, K., Rajapaksha, H., Wegener, K., & Bruning, J. (2017). Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21. FEBS Journal, 284(6), 985-1002.
DOI Scopus2 WoS2 Europe PMC1
Lauren has great mentoring experience demonstrating undergraduate chemistry practicals. She has mentored first, second and final year chemistry students in organic and medicinal chemistry subjects.
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