Kylie Yang

Research Interests

Sensor Technology Cell Biology Cancer therapy (excl. chemotherapy and radiation therapy) Microscopy Drug discovery Cancer Cell Biology Antimicrobials, antifungals and biocides Photonic and electro-optical devices, sensors and systems (excl. communications)

Kylie Yang

School of Physics, Chemistry and Earth Sciences

Faculty of Sciences, Engineering and Technology

Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.

Kylie obtained her PhD on fluorescence sensing at the University of Sydney in 2021 under the supervision of Professor Elizabeth New. This was followed by a postdoctoral position at the University College London working with Dr Cally Haynes on transmembrane ion transport. Kylie returned to Australia to her current role as a Lecturer in the discipline of Chemistry at the University of Adelaide in 2025.

My research focuses on understanding the abnormal chemical reactivity that occurs within diseased microenvironments. By designing new chemical tools, we can develop smart sensors and therapeutics that will specifically react within within target tissue such as solid tumours. This can be used to build activatable sensors and therapeutics that specifically target a feature associated with disease. To do this, we aim to identify unique reactive chemical species that are found within diseased tissue that are absent in normal tissue. Our goal is to build sensors and therapeutics that exploit this difference in chemical reactivity for selective disease targeting.

My projects aim to develop:

  • Activatable drug carriers and drug conjugates that target solid tumours
  • Fluorescent probes for imaging cancer biomarkers
  • High-throughput screening methods to identify antimicrobial and cytotoxic agents
  • Probes for super-resolution microscopy

If you are interested in discussing any of these projects or working together, please come by my office or drop me an email!

 

Contact information:

Office: Badger 230

email: kylie.yang@adelaide.edu.au

Date Position Institution name
2025 - ongoing Lecturer in Medicinal Chemistry University of Adelaide
2021 - 2025 Postdoctoral Research Associate University College London

Date Institution name Country Title
2021 University of Sydney Australia PhD

Year Citation
2025 Yang, K., Lee, L. C., Kotak, H. A., Morton, E. R., Chee, S. M., Nguyen, D. P. M., . . . Haynes, C. J. E. (2025). High‐Throughput and Automated Anion Transport Assays. Chemistry–Methods, 5(8), 5 pages.
DOI WoS3
2022 Yang, K., Boles, J. E., White, L. J., Hilton, K. L. F., Lai, H. Y., Long, Y., . . . Haynes, C. J. E. (2022). A water-soluble membrane transporter for biologically relevant cations. RSC Advances, 12(43), 27877-27880.
DOI Scopus5 WoS4 Europe PMC3
2022 Yang, K., Kotak, H. A., & Haynes, C. J. E. (2022). Metal-organic ion transport systems. Coordination Chemistry Reviews, 470, 214705.
DOI Scopus15 WoS14
2022 Yang, K., Pavic, K., Bowyer, A. A., Manolios, N., & New, E. J. (2022). Supplementing clinical diagnostics of erosive joint diseases with bio-inspired ratiometric sensors. Frontiers in Sensors, 3.
DOI
2021 Lin, J., Yang, K., & New, E. J. (2021). Strategies for organelle targeting of fluorescent probes. Organic and Biomolecular Chemistry, 19(43), 9339-9357.
DOI Scopus63 WoS65 Europe PMC40
2020 Leslie, K. G., Kolanowski, J. L., Trinh, N., Carrara, S., Anscomb, M. D., Yang, K., . . . New, E. J. (2020). Nicotinamide-appended fluorophores as fluorescent redox sensors. Australian Journal of Chemistry, 73(10), 895-902.
DOI Scopus3 WoS2
2018 Müllner, M., Yang, K., Kaur, A., & New, E. J. (2018). Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids. Polymer Chemistry, 9(25), 3461-3465.
DOI Scopus47 WoS47
2018 Yang, K., Leslie, K. G., Kim, S. Y., Kalionis, B., Chrzanowski, W., Jolliffe, K. A., & New, E. J. (2018). Tailoring the properties of a hypoxia-responsive 1,8-naphthalimide for imaging applications. Organic and Biomolecular Chemistry, 16(4), 619-624.
DOI Scopus27 WoS27 Europe PMC15
2017 Graziotto, M. E., Akerfeldt, M. C., Gunn, A. P., Yang, K., Somerville, M. V., Coleman, N. V., . . . New, E. J. (2017). The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex. Journal of Inorganic Biochemistry, 177, 328-334.
DOI Scopus11 WoS11 Europe PMC6
2017 Yang, K., Kolanowski, J. L., & New, E. J. (2017). Mitochondrially targeted fluorescent redox sensors. Interface Focus, 7(2), 14 pages.
DOI Scopus26 WoS25 Europe PMC16
2017 Wu, A., Kolanowski, J. L., Boumelhem, B. B., Yang, K., Lee, R., Kaur, A., . . . Rendina, L. M. (2017). A Carborane-Containing Fluorophore as a Stain of Cellular Lipid Droplets. Chemistry an Asian Journal, 12(14), 1704-1708.
DOI Scopus30 WoS30 Europe PMC12

Year Citation
2017 Kaur, A., Lim, Z., Yang, K., & New, E. J. (2017). Fluorescent Sensors for Biological Metal Ions. In Comprehensive Supramolecular Chemistry II (Vol. 8, pp. 295-317). Elsevier.
DOI Scopus7

Year Citation
2025 Popoola, P., Allam, T., Lilley, R., Manwani, C., Keers, O., Tan, J., . . . Hiscock, J. (2025). Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer.
DOI
2024 Yang, K., Lee, L., Kotak, H., Morton, E., Chee, S. M., Nguyen, D., . . . Haynes, C. (2024). High-throughput and Automated Anion Transport Assays.
DOI

Medicinal and Biological Chemistry II

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