Kylie Van Der Hoek

Teaching Strengths

qRTPCR
Virology

Dr Kylie Van Der Hoek

NHMRC Grant-Funded Research Fellow

School of Biological Sciences

College of Science

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Dr Kylie Van der Hoek is virologist with more than 14 years of NHMRC-funded research experience investigating viral pathogenesis, antiviral immunity, and emerging infectious diseases. Her research combines molecular virology, viral genomics, metagenomics, and bioinformatics to understand virus-host interactions, viral diversity, and disease emergence. Her recent research is focused on understanding of host antiviral responses to emerging viruses, including Zika virus infection of the placenta and female reproductive tract. She also has expertise in viral discovery and characterisation of viruses in field samples, including circulating in South Australian Grey-Headed flying fox populations, with a view to determining innate immune factors influencing viral spillover. She has expertise in next-generation sequencing, viral genome assembly, transcriptomics, CRISPR-based technologies, and analysis of host-virus interactions. Through collaborations spanning wildlife ecology, veterinary science, placental biology and infectious disease research, my work aims to improve understanding of emerging and zoonotic viruses, to strengthen pandemic preparedness and i9mprove human health. 

Date Position Institution name
2009 - ongoing NH&MRC Funded Post-Doctoral Scientist University of Adelaide

Date Institution name Country Title
2000 - 2005 University of Adelaide Australia PhD, Obstetrics and Gynaecology
1993 - 1993 Anatomy and Histology, University of Adelaide Australia BSc (Hons)

Year Citation
2026 Van der Hoek, K. H., Jankovic-Karasoulos, T., McCullough, D., Coldbeck-Shackley, R. C., Eyre, N. S., Roberts, C. T., & Beard, M. R. (2026). Correction: The first trimester human placenta responds to Zika virus infection inducing an interferon (IFN) and antiviral interferon stimulated gene (ISG) response (Virology Journal, (2025), 22, 1, (108), 10.1186/s12985-025-02729-3). Virology Journal, 23(1), 4 pages.
DOI
2025 Van Der Hoek, K. H., Jankovic-Karasoulos, T., McCullough, D., Coldbeck-Shackley, R. C., Eyre, N. S., Roberts, C. T., & Beard, M. R. (2025). The first trimester human placenta responds to Zika virus infection inducing an interferon (IFN) and antiviral interferon stimulated gene (ISG) response. Virology Journal, 22(1), 108-1-108-15.
DOI Scopus4 WoS4 Europe PMC2
2023 Coldbeck-Shackley, R. C., Romeo, O., Rosli, S., Gearing, L. J., Gould, J. A., Lim, S. S., . . . Beard, M. R. (2023). Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection. PLoS Pathogens, 19(3), 1-26.
DOI Scopus20 WoS19 Europe PMC25
2021 Crosse, K. M., Monson, E. A., Dumbrepatil, A. B., Smith, M., Tseng, Y. -Y., Van Der Hoek, K. H., . . . Helbig, K. J. (2021). Viperin binds STING and enhances the type-I interferon response following dsDNA detection. Immunology and Cell Biology, 99(4), 373-391.
DOI Scopus33 WoS30 Europe PMC38
2021 Khantisitthiporn, O., Shue, B., Eyre, N. S., Nash, C. W., Turnbull, L., Whitchurch, C. B., . . . Beard, M. R. (2021). Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response. Life Science Alliance, 4(7), e202000915-1-e202000915-14.
DOI Scopus10 WoS9 Europe PMC8
2021 Al Shujairi, W. -H., Kris, L. P., Van Der Hoek, K., Cowell, E., Bracho-Granado, G., Woodgate, T., . . . Carr, J. M. (2021). Viperin is anti-viral in vitro but is dispensable for restricting dengue virus replication or induction of innate and inflammatory responses in vivo. Journal of General Virology, 102(10), 001669-1-001669-14.
DOI Scopus7 WoS6 Europe PMC7
2017 Van Der Hoek, K., Eyre, N., Shue, B., Khantisitthiporn, O., Glab-Ampi, K., Carr, J., . . . Beard, M. (2017). Viperin is an important host restriction factor in control of Zika virus infection. Scientific Reports, 7(1), 4475 -1-4475-14.
DOI Scopus98 WoS96 Europe PMC92
2016 Fiches, G., Eyre, N., Aloia, A., Van Der Hoek, K., Betz-Stablein, B., Luciani, F., . . . Beard, M. (2016). HCV RNA traffic and association with NS5A in living cells. Virology, 493, 60-74.
DOI Scopus10 WoS10 Europe PMC10
2015 Tse, E., Helbig, K., Van der Hoek, K., McCartney, E., Van der Hoek, M., George, J., & Beard, M. (2015). Fatty acids induce a pro-inflammatory gene expression profile in Huh-7 cells that attenuates the anti-HCV action of interferon. Journal of Interferon and Cytokine Research, 35(5), 392-400.
DOI Scopus18 WoS17 Europe PMC12
2012 Phillips, R., Helbig, K., Van Der Hoek, K., Seth, D., & Beard, M. (2012). Osteopontin increases hepatocellular carcinoma cell growth in a CD44 dependant manner. World Journal of Gastroenterology, 18(26), 3389-3399.
DOI Scopus35 WoS30 Europe PMC27
2009 Ohlsson Teague, E., Van Der Hoek, K., Van der Hoek, M., Perry, N., Wagaarachchi, P., Robertson, S., . . . Hull, M. (2009). MicroRNA-regulated pathways associated with endometriosis. Molecular Endocrinology, 23(2), 265-275.
DOI Scopus341 WoS324 Europe PMC276
2007 Wu, R., Fujii, S., Ryan, N., Van Der Hoek, K., Jasper, M., Sini, I., . . . Norman, R. (2007). Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome. Human Reproduction, 22(2), 527-535.
DOI Scopus94 WoS91 Europe PMC80
2006 Haynes, C., Ryan, N., Van Der Hoek, K., Robker, R., & Norman, R. (2006). Troglitazone regulates peroxisome proliferator-activated receptors and inducible nitric oxide synthase in murine ovarian macrophages. Biology of Reproduction, 74(1), 153-160.
DOI Scopus32 WoS28 Europe PMC25
2004 Wu, R., Van Der Hoek, K., Ryan, N., Norman, R., & Robker, R. (2004). Macrophage contributions to ovarian function. Human Reproduction Update, 10(2), 119-133.
DOI Scopus306 WoS291 Europe PMC253
2003 Ryan, N., Van Der Hoek, K., Robertson, S., & Norman, R. (2003). Leptin and leptin receptor expression in the rat ovary. Endocrinology, 144(11), 5006-5013.
DOI Scopus76 WoS69 Europe PMC48
2002 Ryan, N., Woodhouse, C., Van Der Hoek, K., Gilchrist, R., Armstrong, D., & Norman, R. (2002). Expression of leptin and its receptor in the murine ovary: Possible role in the regulation of oocyte maturation. Biology of Reproduction, 66(5), 1548-1554.
DOI Scopus131 WoS111 Europe PMC90
2002 Duggal, P., Ryan, N., Van Der Hoek, K., Ritter, L., Armstrong, D., Magoffin, D., & Norman, R. (2002). Effects of leptin administration and feed restriction on thecal leucocytes in the preovulatory rat ovary and the effects of leptin on meiotic maturation, granulosa cell proliferation, steroid hormone and PGE2 release in cultured rat ovarian follicles. Reproduction, 123(6), 891-898.
DOI Scopus48 WoS47 Europe PMC38
2000 Van Der Hoek, K., Maddocks, S., Woodhouse, C., van Rooijen, N., Robertson, S., & Norman, R. (2000). Intrabursal injection of clodronate liposomes causes macrophage depletion and inhibits ovulation in the mouse ovary. Biology of Reproduction, 62(4), 1059-1066.
DOI Scopus85 WoS79 Europe PMC69
2000 Jasper, M., Robertson, S., Van Der Hoek, K., Bonello, N., Brannstrom, M., & Norman, R. (2000). Characterization of ovarian function in granulocyte-macrophage colony-stimulating factor-deficient mice. Biology of Reproduction, 62(3), 701-713.
DOI Scopus44 WoS39 Europe PMC29
2000 Duggal, P. S., Van Der Hoek, K. H., Milner, C. R., Ryan, N. K., Armstrong, D. T., Magoffin, D. A., & Norman, R. J. (2000). The in vivo and in vitro effects of exogenous leptin on ovulation in the rat. Endocrinology, 141(6), 1971-1976.
DOI Scopus171 WoS147 Europe PMC118
2000 Duggal, P. S., Van der Hoek, K. H., Milner, C. R., Ryan, N. K., Armstrong, D. T., Magoffin, D. A., & Norman, R. J. (2000). The in Vivo and in Vitro Effects of Exogenous Leptin on Ovulation in the Rat*. Endocrinology, 141(6), 1971-1976.
DOI
1998 Van Der Hoek, K., Woodhouse, C., Brannstrom, M., & Norman, R. (1998). Effects of Interleukin-6 on Luteinizing Hormone and IL-1B-Induced Ovulation and Steroidogenesis in the Rat Ovary. Biology of Reproduction, 58(5), 1266-1271.
DOI Scopus51 WoS45 Europe PMC36
1997 Norman, R. J., Bonello, N., Jasper, M. J., & Van Der Hoek, K. H. (1997). Leukocytes: Essential cells in ovarian function and ovulation. Reproductive Medicine Review, 6(2), 97-111.
DOI Scopus11
1996 Bonello, N., McKie, K., Jasper, M., Andrew, L., Ross, N., Braybon, E., . . . Norman, R. (1996). Inhibition of nitric oxide: effects on interleukin-1beta-enhanced ovulation rate, steroid hormones, and ovarian leukocyte distribution at ovulation in the rat. Biology of Reproduction, 54(2), 436-445.
DOI Scopus168 WoS155 Europe PMC92

Category 1  

2023 - Chief investigator C, NH&MRC Ideas Grant “Awakening the genome to understand and combat viral infection.”(ID 2029424) Awarded 2024-2027.

2020 - Chief Investigator B, NH&MRC Ideas Grant   "Control of Zika Virus Infection of the Female Reproductive Tract and Placenta" (ID 2004090) Awarded 2021-2024. 

Other 

2024 - UofA/Burnet HDR/ECR travel grant. “Metagenomics data analysis techniques for viral discovery” with Dr Joshua Hayward in the Retroviral Biology and Antivirals Laboratory of Prof Gilda Tachedjian. 

2024- Moody Trust Fund application. “Delivery of CRISPRa components into cells as mRNA and its impact on flavivirus replication invitro”   

2022 - Chief Investigator A - Sandlands Bequest funding, University of Adelaide, “Pandemic Preparedness: Viral Discovery and Characterisation in Adelaide’s Botanic Park Grey-headed Flying Fox Colony.” 

2017 - Chief Investigator B - Innovation Seed Funding Grant, Robinson Research Institute, "The impact of Zika virus infection on placenta and neural development during early gestation."  

 

Guest lecture Infection and Immunity IIIA

Develop, deliver and assess practical class sessions for Infection and Immunity IIIA students. 

Date Role Research Topic Program Degree Type Student Load Student Name
2026 Co-Supervisor Can CRISPRa components as RNA be delivered in vitro and in vivo using LNPs as proof of concept for CRISPRa based therapeutics? Master of Research Master Full Time Mr Che Marshall Taylor-Wright
2026 Principal Supervisor Uncovering how low oxygen shapes the placental antiviral response and host-viral protein interactions Doctor of Philosophy Doctorate Full Time Miss Imogen Cate Noutz
2022 Co-Supervisor CRISPR Screening Systems to Identify Novel Virus-Host Interactions and Innate Immune Pathways Doctor of Philosophy Doctorate Full Time Mr Xavier Bernard Montin

Date Role Research Topic Program Degree Type Student Load Student Name
2021 - 2025 Co-Supervisor Understanding the impact of hypoxia and associated signalling pathways on ZIKV and DENV replication and innate antiviral responses Doctor of Philosophy Doctorate Full Time Miss Brooke Nyree Trowbridge

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