Kerrilyn Diener

Dr Kerrilyn Diener

NHMRC Early Career Research Fellow

Adelaide Medical School

Faculty of Health and Medical Sciences

Eligible to supervise Masters and PhD - email supervisor to discuss availability.


Robinson Research Institute Research Fellow
Reproductive Immunology Group; Head, Prof Sarah Robertson: http://www.adelaide.edu.au/robinson-research-institute/researchers/group-leaders/robertson/

Projects:
The effect of maternal anti-viral immune responses on reproductive success
Viruses such as cytomegalovirus and Zika virus are known to affect fetal development. Dr Kerrilyn Diener, in collaboration with Prof Sarah Robertson and Prof John Hayball, are interested in understanding how the maternal immune response to such viral infections during pregnancy can impact on reproductive outcomes. Of particular interest is dissecting out how the maternal innate immune response can change immune and neurodevelopment in the fetus such that offspring exhibit altered immune responses and behavioural abnormalities upon further immune challenges after birth.

The role of HMGB1, a damage-associated molecular pattern (DAMP), in neonatal sepsis
Sepsis, an overwhelming infection, remains a leading cause of death in both adult and neonatal intensive care units, with preterm babies being particularly vulnerable to hospital-acquired infections. Dr Kerrilyn Diener, in collaboration with Prof John Hayball, A/Prof Michael Stark and Dr Nicki Hodyl are investigating how high-mobility box group 1 (HMGB1) potentiates disease. Building on previous studies performed with adult human samples and adult mouse models of disease, we aim to continue development of a passive antibody treatment for septic neonates that will increase survival and reduce the long term morbidity often observed in survivors of neonatal sepsis.

The effect viral infection during the peri-conception period has on the induction of B regulatory cells
Viral infections in humans have been linked to increased proportions of pregnancy complications including preeclampsia, preterm labour and miscarriage, although the mechanisms behind this are unclear. We have recently shown in mouse studies that a sub-clinical viral infection of the uterine tract during the pre-implantation period causes a dramatic reduction in local T regulatory cell numbers and results in decreased pregnancy rates and growth trajectories of resultant offspring. Over the past decade, investigations into a population of suppressor B cells, collectively known as regulatory B cells, have increased, particularly since studies of operationally tolerant (immunosuppression-free) kidney transplant recipients uncovered a molecular signature on the B cells that was different or absent in recipients with stable kidney function on immunosuppression or chronic rejection. Furthermore, evidence suggests that B cells are fundamental in sustaining T regulatory cells, with B cell-deficient mice also exhibiting a reduced frequency of T regulatory cells. One of the hallmarks of B regulatory cells is their capacity to produce IL-10, and in the abortion-prone murine model of pregnancy loss, a lack of CD19+CD5+CD1d+ regulatory IL-10 producing B cells is noted. Whilst within the reproductive field the study of B regulatory cells remains in its infancy, conclusions drawn from studies of other disease states suggests that an intimate relationship between B regulatory cells and T regulatory cells might be necessary for a robust and uneventful pregnancy.

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  • Appointments

    Date Position Institution name
    2017 Robinson Research Institute Research Fellow The University of Adelaide
    2011 - 2016 NHMRC Training Fellow The University of Adelaide
    2010 - 2010 Cure Cancer Australia Postdoctoral Research Officer University of South Australia
    2009 - 2009 Hanson Institute Postdoctoral Research Officer Royal Adelaide Hospital
    2001 - 2008 Research Assistant Royal Adelaide Hospital
    1997 - 2000 Sessional demonstrator (immunology) The University of Adelaide
    1996 - 1996 Research Assistant The University of Adelaide
  • Awards and Achievements

    Date Type Title Institution Name Country Amount
    2011 Recognition Register of Eligible Research Supervisors, The University of Adelaide
    2009 Recognition Register of Postgraduate Research Degree Supervisors, University of South Australia
    2009 Award Sansom Medal University of South Australia
  • Education

    Date Institution name Country Title
    2008 University of South Australia Australia PhD
    1995 The University of Adelaide Australia BSc (Hons)
    1994 The University of Adelaide Australia BSc
  • Research Interests

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  • Journals

    Year Citation
    2021 Guzman-Genuino, R. M., Hayball, J. D., & Diener, K. R. (2021). Regulatory B cells: dark horse in pregnancy immunotherapy?. Journal of Molecular Biology, 433(1), 166596-1-166596-14.
    DOI Scopus1 WoS1
    2020 Wahid, H. H., Chin, P. Y., Sharkey, D. J., Diener, K. R., Hutchinson, M. R., Rice, K. C., . . . Robertson, S. A. (2020). Toll-like receptor-4 antagonist (+)-naltrexone protects against carbamyl-platelet activating factor (Cpaf)-induced preterm labor in mice. American Journal of Pathology, 190(5), 1030-1045.
    DOI Scopus2 WoS2 Europe PMC3
    2020 Garcia-Valtanen, P., van Diermen, B. A., Lakhan, N., Lousberg, E. L., Robertson, S. A., Hayball, J. D., & Diener, K. R. (2020). Maternal host responses to poly(I:C) during pregnancy leads to both dysfunctional immune profiles and altered behaviour in the offspring. American Journal of Reproductive Immunology, 84(2), e13260-1-e13260-11.
    DOI Scopus4 WoS3 Europe PMC3
    2020 Garcia-Valtanen, P., Guzman-Genuino, R. M., Hayball, J. D., & Diener, K. R. (2020). Polyinosinic: polycytidylic acid and murine cytomegalovirus modulate expression of murine IL-10 and IL-21 in white adipose tissue. Viruses, 12(5), 569-1-569-16.
    DOI Scopus1 WoS1 Europe PMC1
    2020 Prow, N. A., Liu, L., McCarthy, M. K., Walters, K., Kalkeri, R., Geiger, J., . . . Suhrbier, A. (2020). The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates. npj Vaccines, 5(1), 10 pages.
    DOI Scopus4 WoS4 Europe PMC2
    2019 Guzman-Genuino, R. M., Dimova, T., You, Y., Aldo, P., Hayball, J. D., Mor, G., & Diener, K. R. (2019). Trophoblasts promote induction of a regulatory phenotype in B cells that can protect against detrimental T cell-mediated inflammation. American Journal of Reproductive Immunology, 82(6), e13187-1-e13187-16.
    DOI Scopus7 WoS7 Europe PMC4
    2019 Kedzior, S., Bianco-Miotto, T., Breen, J., Diener, K., Donnelley, M., Dunning, K., . . . Rumbold, A. (2019). It takes a community to conceive: an analysis of the scope, nature and accuracy of online sources of health information for couples trying to conceive. Reproductive Biomedicine and Society Online, 9, 48-63.
    DOI Scopus3 Europe PMC1
    2019 Stevens, N. E., Nash, C. H., Fraser, C. K., Kuchel, T. R., Maiden, M. J., Chapman, M. J., . . . Hayball, J. D. (2019). High mobility group box protein 1 neutralization therapy in ovine bacteremia: lessons learned from an ovine septic shock model incorporating intensive care support. Experimental and Therapeutic Medicine, 18(5), 3271-3280.
    DOI
    2019 Guzman-Genuino, R. M., Eldi, P., Garcia-Valtanen, P., Hayball, J. D., & Diener, K. R. (2019). Uterine B cells exhibit regulatory properties during the peri-implantation stage of murine pregnancy. Frontiers in Immunology, 10, 2899-1-2899-12.
    DOI Scopus8 WoS9 Europe PMC5
    2018 Lynch, J., Werder, R., Loh, Z., Sikder, M., Curren, B., Zhang, V., . . . Phipps, S. (2018). Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion. Journal of Experimental Medicine, 215(2), 537-557.
    DOI Scopus37 WoS34 Europe PMC30
    2018 Prow, N., Liu, L., Nakayama, E., Cooper, T., Yan, K., Eldi, P., . . . Suhrbier, A. (2018). A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses. Nature Communications, 9(1), 1230-1-1230-12.
    DOI Scopus38 WoS38 Europe PMC29
    2018 Ferrand, J., Croft, N., Pépin, G., Diener, K., Wu, D., Mangan, N., . . . Gantier, M. (2018). The use of CRISPR/Cas9 gene editing to confirm congenic contaminations in host-pathogen interaction studies. Frontiers in Cellular and Infection Microbiology, 8(MAR), 87-1-87-10.
    DOI Scopus1 WoS1 Europe PMC1
    2017 Garcia-Valtanen, P., Guzman-Genuino, R., Williams, D., Hayball, J., & Diener, K. (2017). Evaluation of trained immunity by β-1, 3 (D)-glucan on murine monocytes in vitro and duration of response in vivo. Immunology and Cell Biology, 95(7), 601-610.
    DOI Scopus38 WoS37 Europe PMC28
    2017 Guzman-Genuino, R., & Diener, K. (2017). Regulatory B cells in pregnancy: lessons from autoimmunity, graft tolerance, and cancer. Frontiers in Immunology, 8(FEB), 172-1-172-13.
    DOI Scopus36 WoS34 Europe PMC19
    2017 Liu, L., Cooper, T., Eldi, P., Garcia-Valtanen, P., Diener, K., Howley, P., & Hayball, J. (2017). Transient dominant host-range selection using Chinese hamster ovary cells to generate marker-free recombinant viral vectors from Vaccinia virus. BioTechniques, 62(4), 183-187.
    DOI WoS4 Europe PMC4
    2017 Moldenhauer, L., Diener, K., Hayball, J., & Robertson, S. (2017). An immunogenic phenotype in paternal antigen-specific CD8⁺ T cells at embryo implantation elicits later fetal loss in mice. Immunology and Cell Biology, 95(8), 705-715.
    DOI Scopus13 WoS13 Europe PMC8
    2017 Eldi, P., Cooper, T., Liu, L., Prow, N., Diener, K., Howley, P., . . . Hayball, J. (2017). Production of a Chikungunya Vaccine Using a CHO Cell and Attenuated Viral-Based Platform Technology. Molecular Therapy, 25(10), 1-13.
    DOI Scopus12 WoS12 Europe PMC8
    2017 Stevens, N., Chapman, M., Fraser, C., Kuchel, T., Hayball, J., & Diener, K. (2017). Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes. Scientific Reports, 7(1), 5850-1-5850-14.
    DOI Scopus51 WoS54 Europe PMC35
    2017 Wijesundara, D., Yu, W., Quah, B., Eldi, P., Hayball, J., Diener, K., . . . Grubor-Bauk, B. (2017). Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner. Scientific Reports, 7(1), 8530-1-8530-8.
    DOI Scopus6 WoS6 Europe PMC5
    2016 Diener, K., Robertson, S., Hayball, J., & Lousberg, E. (2016). Multi-parameter flow cytometric analysis of uterine immune cell fluctuations over the murine estrous cycle. Journal of Reproductive Immunology, 113, 61-67.
    DOI Scopus11 WoS11 Europe PMC5
    2016 Christo, S., Bachhuka, A., Diener, K., Mierczynska, A., Hayball, J., & Vasilev, K. (2016). The role of surface nanotopography and chemistry on primary neutrophil and macrophage cellular responses. Advanced Healthcare Materials, 5(8), 956-965.
    DOI Scopus48 WoS44 Europe PMC12
    2016 Christo, S., Diener, K., Manavis, J., Grimbaldeston, M., Bachhuka, A., Vasilev, K., & Hayball, J. (2016). Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses. Scientific Reports, 6(1), 20635-1-20635-14.
    DOI Scopus14 WoS13 Europe PMC2
    2016 Christo, S., Bachhuka, A., Diener, K., Vasilev, K., & Hayball, J. (2016). The contribution of inflammasome components on macrophage response to surface nanotopography and chemistry. Scientific Reports, 6(1), 26207-1-26207-9.
    DOI Scopus26 WoS26 Europe PMC8
    2016 Pinget, G., Corpuz, T., Stolp, J., Lousberg, E., Diener, K., Robertson, S., . . . Webster, K. (2016). The majority of murine γδ T cells at the maternal-fetal interface in pregnancy produce IL-17. Immunology and Cell Biology, 94(7), 623-630.
    DOI Scopus26 WoS27 Europe PMC20
    2016 Stevens, N., Hatjopolous, A., Fraser, C., Alsharifi, M., Diener, K., & Hayball, J. (2016). Preserved antiviral adaptive immunity following polyclonal antibody immunotherapy for severe murine influenza infection. Scientific Reports, 6(1), 1-13.
    DOI Scopus7 WoS7 Europe PMC6
    2016 Lakhan, N., Stevens, N., Diener, K., & Hayball, J. (2016). CoVaccine HT™ adjuvant is superior to Freund's adjuvants in eliciting antibodies against the endogenous alarmin HMGB1. Journal of Immunological Methods, 439, 37-43.
    DOI Scopus8 WoS8 Europe PMC7
    2015 Nenke, M., Rankin, W., Chapman, M., Stevens, N., Diener, K., Hayball, J., . . . Torpy, D. (2015). Depletion of high affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications. Clinical Endocrinology, 82(6), 801-807.
    DOI Scopus35 WoS34 Europe PMC17
    2015 Corrigan, F., Wu, Y., Tuke, J., Coller, J., Rice, K., Diener, K., . . . Hutchinson, M. (2015). Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity, 45, 245-252.
    DOI Scopus16 WoS16 Europe PMC15
    2015 Christo, S., Diener, K., Nordon, R., Brown, M., Griesser, H., Vasilev, K., . . . Hayball, J. (2015). Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus. Scientific Reports, 5(1), 7760-1-7760-8.
    DOI Scopus13 WoS13 Europe PMC12
    2015 Christo, S., Diener, K., & Hayball, J. (2015). The functional contribution of calcium ion flux heterogeneity in T cells. Immunology and Cell Biology, 93(8), 694-704.
    DOI Scopus10 WoS11 Europe PMC7
    2015 Bachhuka, A., Christo, S., Cavallaro, A., Diener, K., Mierczynska, A., Smith, L., . . . Vasilev, K. (2015). Hybrid core/shell microparticles and their use for understanding biological processes. Journal of Colloid and Interface Science, 457, 9-17.
    DOI Scopus12 WoS12 Europe PMC2
    2015 Christo, S., Diener, K., Bachhuka, A., Vasilev, K., & Hayball, J. (2015). Innate immunity and biomaterials at the Nexus: friends or foes. BioMed Research International, 2015, 342304-1-342304-23.
    DOI Scopus58 WoS59 Europe PMC30
    2014 Howley, P. M., Diener, K. R., & Haybal, J. D. (2014). Making an avipoxvirus encoding a tumor-associated antigen and a costimulatory molecule. Methods in Molecular Biology, 1139, 407-427.
    DOI Scopus1 Europe PMC1
    2014 Simovic, S., Diener, K., Bachhuka, A., Kant, K., Losic, D., Hayball, J., . . . Vasilev, K. (2014). Controlled release and bioactivity of the monoclonal antibody rituximab from a porous matrix: a potential in situ therapeutic device. Materials Letters, 130, 210-214.
    DOI Scopus10 WoS10
    2013 Diener, K., Al-Dasooqi, N., Lousberg, E., & Hayball, J. (2013). The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer. Immunology and Cell Biology, 91(7), 443-450.
    DOI Scopus57 WoS55 Europe PMC47
    2013 Stevens, N., Fraser, C., Alsharifi, M., Brown, M., Diener, K., & Hayball, J. (2013). An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant. PLoS One, 8(7), 1-10.
    DOI Scopus6 WoS6 Europe PMC4
    2013 Care, A., Diener, K., Jasper, M., Brown, H., Ingman, W., & Robertson, S. (2013). Macrophages regulate corpus luteum development during embryo implantation in mice. Journal of Clinical Investigation, 123(8), 3472-3487.
    DOI Scopus113 WoS105 Europe PMC71
    2013 Kaiko, G., Loh, Z., Spann, K., Lynch, J., Lalwani, A., Zheng, Z., . . . Phipps, S. (2013). Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice. Journal of Allergy and Clinical Immunology, 131(5), 1331-1349.
    DOI Scopus51 WoS50 Europe PMC42
    2012 Coad, B., Vasilev, K., Diener, K., Hayball, J., Short, R., & Griesser, H. (2012). Immobilized Streptavidin gradients as bioconjugation platforms. Langmuir, 28(5), 2710-2717.
    DOI Scopus30 WoS31 Europe PMC7
    2012 Christo, S., Sarvestani, G., Griesser, S., Coad, B., Griesser, H., Vasilev, K., . . . Hayball, J. (2012). Individual and population quantitative analyses of calcium flux in T-cells activated on functionalized material surfaces. Australian Journal of Chemistry, 65(1), 45-49.
    DOI Scopus7 WoS7
    2012 Diener, K., Christo, S., Griesser, S., Tahmasebi-Sarvestani, G., Vasilev, K., Griesser, H., & Hayball, J. (2012). Solid-state capture and real-time analysis of individual T cell activation via self-assembly of binding multimeric proteins on functionalized materials surfaces. Acta Biomaterialia, 8(1), 99-107.
    DOI Scopus14 WoS14 Europe PMC6
    2012 Kumeria, T., Kurkuri, M., Diener, K., Parkinson, L., & Losic, D. (2012). Label-free reflectometric interference microchip biosensor based on nanoporous alumina for detection of circulating tumour cells. Biosensors & Bioelectronics, 35(1), 167-173.
    DOI Scopus98 WoS88 Europe PMC34
    2011 Lousberg, E., Diener, K., Brown, M., & Hayball, J. (2011). Innate immune recognition of poxviral vaccine vectors. Expert Review of Vaccines, 10(10), 1435-1449.
    DOI Scopus12 WoS14 Europe PMC12
    2011 Furuya, Y., Chan, J., Wan, E., Koskinen, A., Diener, K., Hayball, J., . . . Alsharifi, M. (2011). Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway. PLoS One, 6(10), e25765-1-e25765-12.
    DOI Scopus12 WoS12 Europe PMC8
    2011 Lousberg, E., Diener, K., Fraser, C., Phipps, S., Foster, P., Chen, W., . . . Hayball, J. (2011). Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition. Journal of Virology, 85(7), 3385-3396.
    DOI Scopus9 WoS9 Europe PMC6
    2010 Fraser, C., Lousberg, E., Guerin, L., Hughes, T., Brown, M., Diener, K., & Hayball, J. (2010). Dasatinib alters the metastatic phenotype of B16-OVA melanoma in vivo. Cancer Biology & Therapy, 10(7), 715-727.
    DOI Scopus10 WoS9 Europe PMC8
    2010 Fraser, C., Diener, K., Lousberg, E., Both, G., Ward, L., Brown, M., & Hayball, J. (2010). Induction of both cellular and humoral immunity following a rational prime-boost immunization regimen that incorporates recombinant ovine atadenovirus and fowlpox virus. Clinical and Vaccine Immunology, 17(11), 1679-1686.
    DOI Scopus5 WoS5 Europe PMC4
    2010 Fraser, C., Brown, M., Diener, K., & Hayball, J. (2010). Unravelling the complexity of cancer-immune system interplay. Expert Review of Anticancer Therapy, 10(6), 917-934.
    DOI Scopus4 WoS4 Europe PMC2
    2010 Diener, K., Need, E., Buchanan, G., & Hayball, J. (2010). TGF-β signalling and immunity in prostate tumourigenesis. Expert Opinion On Therapeutic Targets, 14(2), 179-192.
    DOI Scopus18 WoS20 Europe PMC15
    2010 Lousberg, E., Fraser, C., Tovey, M., Diener, K., & Hayball, J. (2010). Type I interferons mediate the innate cytokine response to recombinant fowlpox virus but not the induction of plasmacytoid dendritic cell-dependent adaptive immunity. Journal of Virology, 84(13), 6549-6563.
    DOI Scopus10 WoS11 Europe PMC8
    2009 Fraser, C., Lousberg, E., Kumar, R., Hughes, T., Diener, K., & Hayball, J. (2009). Dasatinib inhibits the secretion of TNF-α following TLR stimulation in vitro and in vivo. Experimental Hematology, 37(12), 1435-1444.
    DOI Scopus32 WoS31 Europe PMC28
    2009 Moldenhauer, L., Diener, K., Thring, D., Brown, M., Hayball, J., & Robertson, S. (2009). Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy. Journal of Immunology, 182(12), 8080-8093.
    DOI Scopus160 WoS151 Europe PMC115
    2009 Diener, K., Woods, A., Manavis, J., Brown, M., & Hayball, J. (2009). Transforming growth factor-β-mediated signaling in T lymphocytes impacts on prostate-specific immunity and early prostate tumor progression. Laboratory Investigation, 89(2), 142-151.
    DOI Scopus14 WoS14 Europe PMC13
    2009 Fraser, C., Blake, S., Diener, K., Lyons, A., Brown, M., Hughes, T., & Hayball, J. (2009). Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo. Experimental Hematology, 37(2), 256-265.
    DOI Scopus52 WoS50 Europe PMC43
    2008 Diener, K., Lousberg, E., Beukema, E., Yu, A., Howley, P., Brown, M., & Hayball, J. (2008). Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help. Vaccine, 26(29-30), 3566-3573.
    DOI Scopus9 WoS7 Europe PMC6
    2008 Diener, K., Moldenhauer, L., Lyons, A., Brown, M., & Hayball, J. (2008). Human Flt-3 ligand-mobilized dendritic cells, require additional activation to drive effective immune responses. Experimental Hematology, 36(1), 51-60.
    DOI Scopus15 WoS15 Europe PMC12
    2007 Fraser, C., Diener, K., Brown, M., & Hayball, J. (2007). Improving vaccines by incorporating immunological coadjuvants. Expert Review of Vaccines, 6(4), 559-578.
    DOI Scopus71 WoS64 Europe PMC45
    2007 Al-ejeh, F., Darby, J., Pensa, K., Diener, K., Hayball, J., & Boucaut, R. (2007). In vivo targeting of dead tumor cells in a Murine Tumor Model using a monoclonal antibody specific for the La Autoantigen. Clinical Cancer Research, 13(18), 5519-5527.
    DOI Scopus28 WoS23 Europe PMC14
    2007 Fraser, C. K., Diener, K. R., Brown, M. P., & Hayball, J. D. (2007). Erratum: Improving vaccines by incorporating immunological coadjuvants (Expert Review Vaccines (2007) 6, 4, (559-578)). Expert Review of Vaccines, 6(6), 1022.
    DOI
    2007 Fares, A. E., Darby, J. M., Pensa, K., Diener, K. R., Haybal, J. D., & Brown, M. P. (2007). Erratum: Article on la Autoantigen (Clinical Cancer Research (2007) 13, (5519s-5527s)). Clinical Cancer Research, 13(20), 645.
    DOI
    2007 Fraser, C. K., Diener, K. R., Brown, M. P., & Hayball, J. D. (2007). Improving vaccines by incorporating immunological coadjuvants (vol 6, pg 559, 2007). EXPERT REVIEW OF VACCINES, 6(6), 1022.
    2007 Fares, A. -E., Darby, J., Pensa, K., Diener, K., Hayball, J., & Brown, M. (2007). In vivo targeting of dead tumor cells in a murine tumor model using a monoclonal antibody specific for the La autoantigen (vol 13, pg 5519, 2007). CLINICAL CANCER RESEARCH, 13(20), 6245.
    DOI WoS1
    2006 Lees, J., Charbonneau, B., Hayball, J., Diener, K., Brown, M., Matusik, R., . . . Ratliff, T. (2006). T-cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction. Prostate, 66(6), 578-590.
    DOI Scopus21 WoS21 Europe PMC20
    2002 Moghaddami, M., Swart, B., Reynolds, P., Diener, K., & Brown, M. (2002). Flt3 ligand expands dendritic cell numbers in normal and malignant murine prostate. Immunology and Cell Biology, 80(4), 370-381.
    DOI Scopus6 WoS7 Europe PMC4
    2002 Moghaddami, M., Swart, B., Reynolds, P., Diener, K., & Brown, M. P. (2002). Erratum: Flt3 ligand expands dendritic cell numbers in normal and malignant murine prostate (Immunology and Cell Biology (2002) 80 (370-381)). Immunology and Cell Biology, 80(5), 507.
    DOI
    2000 Diener, K. R., & McMoll, S. R. (2000). Evaluation of macrophage inflammatory protein-3 alpha (MIP-3 alpha) expression in rheumatoid arthritis.. FASEB JOURNAL, 14(6), A1211.
    1998 Diener, K., Tessier, P., Fraser, J., Königen, F., & McColl, S. R. (1998). Induction of acute inflammation in vivo by staphylococcal superantigens I: Leukocyte recruitment occurs independently of T lymphocytes and major histocompatibility complex class II molecules. Laboratory Investigation, 78(6), 647-656.
    Scopus13 WoS11 Europe PMC9
    1998 Diener, K., Tessier, P., John, F., Kontgen, F., & McColl, S. (1998). Introduction of Acute Inflammation In Vivo by Staphylococcal Superantigens 1: Leukocyte Recruitment Occurs Independently of T lymphocytes and Major Histocompatibility Complex Class II Molecules. Laboratory Investigation, 78, 647-656.
    1998 Tessier, P., Naccache, P., Diener, K., Gladue, R., Neote, K., Clark-Lewis, I., & McColl, S. (1998). Induction of Acute Inflammation in vivo by Staphylococcal Superantigens II. Critical Role for Chemokines ICAM-i and TNF-alpha. Journal of Immunology, 161(3), 1204-1211.
    Scopus66 WoS67 Europe PMC50
  • Conference Papers

    Year Citation
    2018 Genuino, R. M. G., Eldi, P., Garcia-Valtanen, P., Hayball, J. D., & Diener, K. R. (2018). Lymphatic and uterine B cells contribute to maternal immunological tolerance during murine pregnancy. In JOURNAL OF IMMUNOLOGY Vol. 200 (pp. 3 pages). Austin, TX: AMER ASSOC IMMUNOLOGISTS.
    2012 Kumeria, T., Kurkuri, M., Diener, K., Parkinson, L., & Losic, D. (2012). Reflectometric interference microchip based on nanoporous alumina for label-free detection of circulating tumour cells. In Proceedings of the 10th Asia-Pacific Microscopy Conference, APMC10, the International Conference on Nanoscience & Nanotechnology, ICONN2012 and the 22nd Australian Conference on Microscopy & Microanalysis, ACMM22 (pp. 746-1-746-3). Perth.
    2011 Kumeria, T., Kurkuri, M., Diener, K., Zhang, C., Parkinson, L., & Losic, D. (2011). Reflectometric interference biosensing using nanopores: integration into microfluidics. In Proceedings of SPIE - The International Society for Optical Engineering Vol. 8204 (pp. 1-11). Australia: SPIE.
    DOI

2016       Channel 7 Children’s Research Foundation
Investigations into sepsis-induced high-mobility group box 1 (HMGB1) and effects on neurodevelopment in survivors of neonatal sepsis. KR Diener, N Hodyl, M Stark, J Hayball, X-F Zhou.
Awarded $75,000 (2017-2018)

2016       Robinson Research Institute Innovation Seed Funding Program
Exploring Zika virus disease pathology and vaccine efficacy in pregnant mouse models. K.R. Diener, H. Marshall, S.A. Robertson, J.D. Hayball, A. Suhrbier
Awarded $25,000 (2017)

2016       Robinson Research Institute Engaging Opportunities Program
The conception of a preconception resource-#rightmessage #rightaudience #righttime #conceptionhealthmatters. RRI E/MCR Conception Consortium: Dr Hannah Brown, Dr Kerri Diener, Dr Jimmy Breen, Dr Alice Rumbold, Dr Nicki Hodyl, Dr Tod Fullston, Dr John Schjenken, Dr David Sharkey, Dr Martin Donnelley, Dr Tina Bianco-Miotto, Dr Megan Penno.
Awarded $25,000 (2017)

2016       Robinson Research Institute Travel Grant
‘Murine cytomegalovirus infection during early pregnancy impacts on reproductive outcomes’. K.R.Diener.
Awarded $550 (2016)

2015       Robinson Research Institute Innovation Seed Funding Program
Investigations into the effect viral infection during the peri-conception period has on the induction of B regulatory cells, and what role a lack of these have on subsequent susceptibility to miscarriage and/or preterm delivery. K.R. Diener, N Hodyl, S. Barry and J.D. Hayball
Awarded $25,000 (2015-2016)

2014       Robinson Research Institute Innovation Seed Funding Program
The development of a new passive immunotherapeutic for the treatment and prevention of sepsis in mouse neonates. K. R. Diener, J. D. Hayball, M Stark, and N Hodyl
Awarded $25,000 (2014-2015).

2012       Robinson Institute Travel Grant
‘Role of plasmacytoid dendritic cells within the uterine tract’. K.R.Diener.
Awarded $1300 (2012).

2012       NHMRC Project Grant, Application ID 1020984
‘The consequences of innate immune inflammatory responses during early pregnancy and their effect on reproductive outcomes’. K.R.Diener
Awarded $326,175 (2012-2014)

2011       NHMRC Equipment Grant, Applications ID GNT9000031
‘Becton Dickinson FACSCanto II Three Colour Flow Cytometer’. W.V.Ingman, S.A.Robertson, R.J.Rodgers, D.L.Russell, M.Lane, V.L.Clifton, M.L.Hull, M.R.Hutchinson, and K.R.Diener
Awarded $90,000 (2011)

2011       NHMRC Training Fellowship, Application ID 1012386
‘Innate anti-viral effector responses and adverse reproductive outcomes’. K.R.Diener
Awarded $290,032 (2011-2013 full-time; 2015-2016 part-time)

2011       Royal Adelaide Hospital Research Committee Mary Overton Early Career Research Fellowship
‘A comparative analysis of the relative therapeutic efficacy of phenotypically-distinct populations of genetically-modified tumour-specific T cells as detected and assessed by functionalised solid support surfaces’. K.R.Diener
Awarded $252,000 (2011-2013)
Note: rescinded due to acceptance of NHMRC Training Fellowship

2011       Royal Adelaide Hospital Research Committee Project Grant
‘Assessing the neutralising activity of therapeutic antibodies directed against the endogenous alarmin HMGB1 in serum samples from septic shock patients and in an experimental murine model of bacterial sepsis’. K.R.Diener, J.D. Hayball and M.J. Chapman.
Awarded $25,000 (2011)

2010       NHMRC/Cancer Australia, Priority-driven Collaborative Cancer Research Scheme, Application ID 631921.
‘Development of microfluidic chips to isolate and analyse peripheral blood cell populations in pancreatic cancer patients’. K.R. Diener.
Awarded $90,000 (2010)

2010       University of South Australia Competitive Research Development Grants Scheme
‘Early anti-viral immune responses within the reproductive tract and the effect on reproductive outcomes’. K.R.Diener and J.D.Hayball
Awarded $15,000 (2010)

2010       University of South Australia Competitive NHMRC Project Grant Funding Scheme
‘A comparative analysis of the relative therapeutic efficacy of phenotypically-distinct populations of genetically-modified tumour-specific T cells as detected and assessed by functionalised solid support surfaces’. K.R.Diener, H.J.Griesser, J.D.Hayball, M.P.Brown, and K.Vasilev
Awarded $10,000 (2010)

2006       Royal Adelaide Hospital Research Committee Clinical Project Grant
‘An investigation of autophagy in response to hormone deprivation in prostate cancer: implications for therapeutic treatment regimes’. M.P. Brown, K.R. Diener, and J.D. Hayball. Awarded $20,000 (2006)

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  • Past Higher Degree by Research Supervision (University of Adelaide)

    Date Role Research Topic Program Degree Type Student Load Student Name
    2013 - 2017 Co-Supervisor Toll-Like Receptor 4 Signalling in Inflammation Pathways to Term and Preterm Delivery Doctor of Philosophy Doctorate Full Time Miss Hanan Hamimi Binti Wahid
  • Other Supervision Activities

    Date Role Research Topic Location Program Supervision Type Student Load Student Name
    2018 - ongoing Co-Supervisor Development of a virus-vectored vaccine against Hepatitis A and B viruses using a novel vaccine platform University of South Australia Doctorate Fan Jia
    2015 - ongoing Principal Supervisor Elucidating the role of B regulatory cells in pregnancy University of South Australia Doctorate Ruth Marian Guzman-Genuino
    2013 - 2018 Principal Supervisor The innate recognition of murine cytomegalovirus during the pre-implantation period and consequences for pregnancy University of South Australia Doctorate Shamika Moore
    2012 - 2017 Co-Supervisor Development and evaluation of ovine polyclonal antibody therapies for the treatment of sever influenza infection and bacterial sepsis University of South Australia Doctorate Natalie Stevens
    2011 - 2015 Co-Supervisor The use of biomaterials to investigate and modulate innate and adaptive immunity University of South Australia Doctorate Susan Christo
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  • Committee Memberships

    Date Role Committee Institution Country
    2011 - 2017 Member PdCCRS/NHMRC Grant Review Committee (Cancer Australia)
  • Memberships

    Date Role Membership Country
    2012 - ongoing Developmental Origins for Health and Disease Australia and New Zealand (DOHaD ANZ)
    2011 - ongoing Society for Reproductive Biology (SRB)
    1995 - ongoing Australasian Society for Immunology (ASI)
  • Position: NHMRC Early Career Research Fellow
  • Phone: 83131505
  • Email: kerrilyn.diener@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 6
  • Room: WS6071.11
  • Org Unit: Women's and Children's Health

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