Keith Jones

Professor Keith Jones

Executive Dean, Faculty of Sciences

Sciences Office

Faculty of Sciences

In October 2018 Keith became the Executive Dean of the Faculty of Sciences at the University of Adelaide.

Keith was awarded a PhD from the University of Liverpool in cell physiology, then moved to the MRC Experimental Embryology Unit at St George’s in London under the directorship of David Whittingham. He crossed the river to work with Karl Swann at UCL, before moving even further north to Physiological Sciences at University of Newcastle-upon-Tyne, where he worked between 1998-2007.

Between 2008 and 2012 he worked in the School of Biomedical Sciences & Pharmacy at the University of Newcastle, Australia, where he was Head of Research for the School, and Discipline lead for Human Physiology. During this time he was a member of the ARC's College of Experts, and a REC panel member in Biology for ERA2012.

Between 2013 and 2018 he joined the University of Southampton, UK, to take up the role of Head of Biological Sciences. During this time he was a members of the BBSRC's Genes, Development and STEM approaches to Biology committee.

Keith’s research interests focus on oocytes, which have been used in many aspects of cell biology to uncover how cells work. His laboratory is concerned with how the process of meiosis is co-ordinated to produce a healthy mature egg that is capable of being fertilized by the sperm at fertilization. This includes studying how the protracted arrest of mammalian oocytes in prophase is regulated, how chromosomes are separated faithfully, and how a calcium signal at fertilization drives completion of the second meiotic division. His research group is therefore concerned with the events going on inside the oocyte that are responsible for these stops and starts of the meiotic cell cycle.

  • Appointments
    Date Position Institution name
    2018 Executive Dean University of Adelaide
    2013 - 2018 Head of School University of Southampton
    2013 Professor of Cell Biology University of Southampton
    2008 - 2008 Reader in Reproductive Physiology University of Newcastle upon Tyne
    2008 - 2012 Professor of Human Physiology and Head of Discipline University of Newcastle Australia
    2005 - 2007 Professor of Reproductive Physiology University of Newcastle upon Tyne
    2002 - 2005 Senior Lecturer University of Newcastle upon Tyne
    1998 - 2002 Lecturer University of Newcastle upon Tyne

  • Education
    Date Institution name Country Title
    1991 - 1994 University of Liverpool United Kingdom PhD
    1985 - 1989 University of Leeds United Kingdom BSc Biochemistry (First Class Hons)

  • Research Interests
    Cell and Nuclear Division Cell Biology Cell Physiology Reproductive Biology

  • Journals
    Year Citation
    2018 Jones, K. (2018). Mammalian sperm contain two factors for calcium release and egg activation: Phospholipase C zeta and a cryptic activating factor. Molecular Human Reproduction, 24(10), 465-468.
    DOI Scopus2 WoS1
    2018 Sanders, J., & Jones, K. (2018). Regulation of the meiotic divisions of mammalian oocytes and eggs. Biochemical Society Transactions, 46(4), 797-806.
    DOI Scopus7 Europe PMC3
    2018 Jones, K. (2018). MHR. Molecular Human Reproduction, 25(1), 1.
    DOI
    2018 Wu, T., Lane, S., Morgan, S., & Jones, K. (2018). Spindle tubulin and MTOC asymmetries may explain meiotic drive in oocytes. Nature Communications, 9(1), 11 pages.
    DOI Scopus8 WoS5 Europe PMC3
    2018 Łuksza, M., Kanaan, J., Marthiens, V., Lane, S., Jones, K., Terret, M., . . . Verlhac, M. (2018). Chromosome structural anomalies due to aberrant spindle forces exerted at gene editing sites in meiosis. The Journal of Cell Biology, 217(10), 3416-3430.
    DOI Scopus4 WoS5 Europe PMC1
    2018 Manil-Ségalen, M., Łuksza, M., Kannaan, J., Marthiens, V., Lane, S. I., Jones, K., . . . Verlhac, M. -H. (2018). Gene editing can generate fragile bivalents in mouse oocytes.
    DOI
    2017 Lane, S., & Jones, K. (2017). Chromosome biorientation and APC activity remain uncoupled in oocytes with reduced volume. Journal of Cell Biology, 216(12), 3949-3957.
    DOI Scopus11 WoS10 Europe PMC3
    2017 Lane, S., Morgan, S., Wu, T., Collins, J., Merriman, J., Elinati, E., . . . Jones, K. (2017). DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes. Development (Cambridge), 144(19), 3475-3486.
    DOI Scopus17 WoS16 Europe PMC10
    2016 Hamdan, M., Jones, K., Cheong, Y., & Lane, S. (2016). The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis. Scientific Reports, 6(1), 1-8.
    DOI Scopus12 WoS14 Europe PMC6
    2016 Collins, J., & Jones, K. (2016). DNA damage responses in mammalian oocytes. Reproduction, 152(1), 15-22.
    DOI Scopus18 WoS19 Europe PMC9
    2016 Zarate-Garcia, L., Lane, S., Merriman, J., & Jones, K. (2016). FACS-sorted putative oogonial stem cells from the ovary are neither DDX4-positive nor germ cells. Scientific Reports, 6(1), 9 pages.
    DOI Scopus22 WoS21 Europe PMC12
    2015 Collins, J., Lane, S., Merriman, J., & Jones, K. (2015). DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint. Nature Communications, 6(1), 12 pages.
    DOI Scopus42 WoS39 Europe PMC23
    2014 Yun, Y., Holt, J., Lane, S., McLaughlin, E., Merriman, J., & Jones, K. (2014). Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice. Cell Cycle, 13(12), 1938-1947.
    DOI Scopus32 WoS30 Europe PMC27
    2014 Lane, S., & Jones, K. (2014). Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes. Nature Communications, 5(1), 3444-1-3444-9.
    DOI Scopus31 WoS32 Europe PMC28
    2014 Holt, J., Pye, V., Boon, E., Stewart, J., García-Higuera, I., Moreno, S., . . . McLaughlin, E. (2014). The APC/C activator FZR1 is essential for meiotic prophase I in mice. Development, 141(6), 1354-1365.
    DOI Scopus15 WoS15 Europe PMC12
    2014 Yun, Y., Lane, S., & Jones, K. (2014). Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes. Development, 141(1), 199-208.
    DOI Scopus55 WoS52 Europe PMC41
    2013 Holt, J. E., Lane, S. I., & Jones, K. T. (2013). Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes.. Methods in molecular biology (Clifton, N.J.), 957, 91-106.
    DOI Europe PMC6
    2013 Jamsai, D., O'Connor, A., DeBoer, K., Clark, B., Smith, S., Browne, C., . . . O'Bryan, M. (2013). Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. PLoS One, 8(2), e56955-1-e56955-7.
    DOI Scopus9 WoS9 Europe PMC7
    2013 Jones, K., & Lane, S. (2013). Molecular causes of aneuploidy in mammalian eggs. Development, 140(18), 3719-3730.
    DOI Scopus104 WoS101 Europe PMC75
    2013 Lord, T., Nixon, B., Jones, K., & Aitken, R. (2013). Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro. Biology of Reproduction, 88(3), 67-1-67-9.
    DOI Scopus79 WoS79 Europe PMC50
    2013 Merriman, J., Lane, S., Holt, J., Jennings, P., García-Higuera, I., Moreno, S., . . . Jones, K. (2013). Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice. Biology of Reproduction, 88(2), 31-1-31-7.
    DOI Scopus16 WoS14 Europe PMC13
    2013 Holt, J., Lane, S., & Jones, K. (2013). Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis i in mouse oocytes. Methods in Molecular Biology, 957, 91-106.
    DOI Scopus7
    2013 Holt, J., Lane, S., & Jones, K. (2013). The Control of Meiotic Maturation in Mammalian Oocytes. GAMETOGENESIS, 102, 207-226.
    DOI Scopus50 WoS48 Europe PMC26
    2012 Holt, J. E., Lane, S. I., Jennings, P., Garcia-Higuera, I., Moreno, S., & Jones, K. T. (2012). APCFZR1 prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing. Molecular Biology of the Cell, 23(20), 3970-3981.
    DOI Scopus25 WoS25 Europe PMC18
    2012 Jones, K., & Lane, S. (2012). Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes. Experimental Cell Research, 318(12), 1394-1399.
    DOI Scopus32 WoS33 Europe PMC25
    2012 Seah, M., Holt, J., García-Higuera, I., Moreno, S., & Jones, K. (2012). The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development. Journal of Cell Science, 125(24), 6030-6037.
    DOI Scopus4 WoS4 Europe PMC4
    2012 Liu, W., Yin, J., Zhao, G., Yun, Y., Wu, S., Jones, K., & Lei, A. (2012). Differential regulation of cyclin B1 degradation between the first and second meiotic divisions of bovine oocytes. Theriogenology, 78(6), 1171-1181.
    DOI Scopus3 WoS3 Europe PMC1
    2012 Lane, S., Yun, Y., & Jones, K. (2012). Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension. Development, 139(11), 1947-1955.
    DOI Scopus92 WoS91 Europe PMC64
    2012 Merriman, J. A., Jennings, P. C., McLaughlin, E. A., & Jones, K. T. (2012). Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months. Biology of Reproduction, 86(2), 49-1-49-6.
    DOI Scopus56 WoS53 Europe PMC44
    2012 Jones, K. (2012). Meiosis: Mouse eggs do their anaphase topsy-turvy. Current Biology, 22(5), R153-R155.
    DOI
    2012 Yuen, W., Merriman, J., O'Bryan, M., & Jones, K. (2012). DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes. PLoS One, 7(8), e43875-1-e43875-9.
    DOI Scopus31 WoS28 Europe PMC20
    2012 Aitken, R., Jones, K., & Robertson, S. (2012). Reactive oxygen species and sperm function - In sickness and in health. Journal of Andrology, 33(6), 1096-1106.
    DOI Scopus183 WoS160 Europe PMC93
    2011 Holt, J., Tran, S., Stewart, J., Minahan, K., García-Higuera, I., Moreno, S., & Jones, K. (2011). The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. Development, 138(5), 905-913.
    DOI Scopus37 WoS36 Europe PMC23
    2011 Jamsai, D., Sarraj, M., Merriner, D., Drummond, A., Jones, K., McLachlan, R., & O'Bryan, M. (2011). GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population. International Journal of Andrology, 34(6 PART 1), 624-632.
    DOI Scopus8 WoS10 Europe PMC7
    2011 Lane, S., & Jones, K. (2011). Phosphorylation of histone H3 in 1- and 2-cell embryos. Cell Cycle, 10(1), 23-22.
    DOI Scopus2
    2011 Chang, H., Jennings, P., Stewart, J., Verrills, N., & Jones, K. (2011). Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720. Journal of Biological Chemistry, 286(16), 14705-14712.
    DOI Scopus29 WoS27 Europe PMC21
    2011 Jennings, P., Merriman, J., Beckett, E., Hansbro, P., & Jones, K. (2011). Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice. Human Reproduction, 26(4), 878-884.
    DOI Scopus37 WoS31 Europe PMC22
    2011 Jones, K. (2011). Anaphase-promoting complex control in female mouse meiosis. Results and Problems in Cell Differentiation, 53, 343-363.
    DOI Scopus20 Europe PMC8
    2011 Lane, S. I., & Jones, K. T. (2011). Phosphorylation of histone H3 in 1- and 2-cell embryos.. Cell cycle (Georgetown, Tex.), 10(1), 17-18.
    Europe PMC1
    2010 Jones, K., & Holt, J. (2010). BubR1 highlights essential function of Cdh1 in mammalian oocytes. Cell Cycle, 9(6), 1025-1030.
    Europe PMC1
    2010 Lane, S., Chang, H., Jennings, P., & Jones, K. (2010). The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint. Reproduction, 140(4), 521-530.
    DOI Scopus50 WoS45 Europe PMC39
    2010 Holt, J., Weaver, J., & Jones, K. (2010). Spatial regulation of APC<sup>Cdh1</sup>-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes. Development, 137(8), 1297-1304.
    DOI Scopus46 WoS39 Europe PMC26
    2010 Jones, K. (2010). Cohesin and Cdk1: An anaphase barricade. Nature Cell Biology, 12(2), 106-108.
    DOI Scopus3 WoS3 Europe PMC1
    2009 Holt, J., & Jones, K. (2009). Control of homologous chromosome division in the mammalian oocyte. Molecular Human Reproduction, 15(3), 139-147.
    DOI Scopus43 WoS41 Europe PMC29
    2009 Chang, H., Minahan, K., Merriman, J., & Jones, K. (2009). Calmodulin-dependent protein kinase gamma 3 (CamKIIγ3) mediates the cell cycle resumption of metaphase II eggs in mouse. Development, 136(24), 4077-4081.
    DOI Scopus37 WoS30 Europe PMC22
    2008 Jones, K. (2008). Meiosis in oocytes: Predisposition to aneuploidy and its increased incidence with age. Human Reproduction Update, 14(2), 143-158.
    DOI Scopus146 WoS134 Europe PMC97
    2008 Nabti, I., Reis, A., Levasseur, M., Stemmann, O., & Jones, K. (2008). Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs. Developmental Biology, 321(2), 379-386.
    DOI Scopus25 WoS24 Europe PMC19
    2007 Reis, A., Madgwick, S., Chang, H., Nabti, I., Levasseur, M., & Jones, K. (2007). Prometaphase APC<sup>cdh1</sup> activity prevents non-disjunction in mammalian oocytes. Nature Cell Biology, 9(10), 1192-1198.
    DOI Scopus79 WoS71 Europe PMC48
    2007 Madgwick, S., & Jones, K. (2007). How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals cytostatic factor. Cell Division, 2, 7 pages.
    DOI Scopus72 WoS62 Europe PMC46
    2007 Jones, K., & Swann, K. (2007). Composition of sea urchin egg homogenate determines its potency to inositol trisphosphate and cyclic ADPRibose-induced Ca<sup>2+</sup> release. Biochemical and Biophysical Research Communications, 360(4), 815-820.
    DOI Scopus3 WoS3 Europe PMC3
    2007 Levasseur, M., Carroll, M., Jones, K., & McDougall, A. (2007). A novel mechanism controls the Ca<sup>2+</sup> oscillations triggered by activation of ascidian eggs and has an absolute requirement for Cdk1 activity. Journal of Cell Science, 120(10), 1763-1771.
    DOI Scopus11 WoS13 Europe PMC9
    2007 Gardner, A., Knott, J., Jones, K., & Evans, J. (2007). CaMKII can participate in but is not sufficient for the establishment of the membrane block to polyspermy in mouse eggs. Journal of Cellular Physiology, 212(2), 275-280.
    DOI Scopus22 WoS21 Europe PMC16
    2006 Knott, J., Gardner, A., Madgwick, S., Jones, K., Williams, C., & Schultz, R. (2006). Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca<sup>2+</sup> oscillations. Developmental Biology, 296(2), 388-395.
    DOI Scopus56 WoS50 Europe PMC35
    2006 Gorr, I., Reis, A., Boos, D., Wühr, M., Madgwick, S., Jones, K., & Stemmann, O. (2006). Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes. Nature Cell Biology, 8(9), 1035-1037.
    DOI Scopus53 WoS47 Europe PMC37
    2006 Reis, A., Chang, H., Levasseur, M., & Jones, K. (2006). APC<sup>cdh1</sup> Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division. Nature Cell Biology, 8(5), 539-540.
    DOI Scopus111 WoS100 Europe PMC67
    2006 Reis, A., Levasseur, M., Chang, H., Elliott, D., & Jones, K. (2006). The CRY box: A second APC<sup>cdh1</sup>-dependent degron in mammalian cdc20. EMBO Reports, 7(10), 1040-1045.
    DOI Scopus57 WoS58 Europe PMC44
    2006 Madgwick, S., Hansen, D., Levasseur, M., Jackson, P., & Jones, K. (2006). Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis. Journal of Cell Biology, 174(6), 791-801.
    DOI Scopus118 WoS115 Europe PMC88
    2005 Madgwick, S., Levasseur, M., & Jones, K. (2005). Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs. Journal of Cell Science, 118(17), 3849-3859.
    DOI Scopus80 WoS72 Europe PMC53
    2005 Coward, K., Ponting, C., Chang, H., Hibbitt, O., Savolainen, P., Jones, K., & Parrington, J. (2005). Phospholipase Cζ, the trigger egg activation in mammals, is present in a non-mammalian species. Reproduction, 130(2), 157-163.
    DOI Scopus75 WoS71 Europe PMC48
    2005 Jones, K. (2005). Mammalian egg activation: From Ca<sup>2+</sup> spiking to cell cycle progression. Reproduction, 130(6), 813-823.
    DOI Scopus102 WoS95 Europe PMC63
    2004 Venables, J., Dalgliesh, C., Paronetto, M., Skitt, L., Thornton, J., Saunders, P., . . . Elliott, D. (2004). SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. Human Molecular Genetics, 13(14), 1525-1534.
    DOI Scopus45 WoS41 Europe PMC30
    2004 Chang, H., Levasseur, M., & Jones, K. (2004). Degradation of APC<sup>cdc20</sup> and APC<sup>cdh1</sup> substrates during the second meiotic division in mouse eggs. Journal of Cell Science, 117(26), 6289-6296.
    DOI Scopus30 WoS29 Europe PMC22
    2004 Hyslop, L., Nixon, V., Levasseur, M., Chapman, F., Chiba, K., McDougall, A., . . . Jones, K. (2004). Ca<sup>2+</sup>-promoted cyclin B1 degradation in mouse oocytes requires the establishment of a metaphase arrest. Developmental Biology, 269(1), 206-219.
    DOI Scopus55 WoS54 Europe PMC36
    2004 Madgwick, S., Nixon, V., Chang, H., Herbert, M., Levasseur, M., & Jones, K. (2004). Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity. Developmental Biology, 275(1), 68-81.
    DOI Scopus43 WoS43 Europe PMC30
    2004 Jones, K. (2004). Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization. Molecular Human Reproduction, 10(1), 1-5.
    DOI Scopus107 WoS117 Europe PMC67
    2003 Soeller, C., Jacobs, M., Jones, K., Ellis-Davies, G., Donaldson, P., & Cannell, M. (2003). Erratum: Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca <sup>2+</sup> movements (Journal of Biomedical Optics (July 2000) 8:3 (418-427)). Journal of Biomedical Optics, 8(4), 668.
    2003 Soeller, C., Jacobs, M., Donaldson, P., Cannell, M., Jones, K., & Ellis-Davies, G. (2003). Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca<sup>2+</sup> movements. Journal of Biomedical Optics, 8(3), 418-427.
    DOI Scopus26 WoS27 Europe PMC16
    2003 Carroll, M., Levasseur, M., Wood, C., Whitaker, M., Jones, K., & McDougall, A. (2003). Exploring the mechanism of action of the sperm-triggered calcium-wave pacemaker in ascidian zygotes. Journal of Cell Science, 116(24), 4997-5004.
    DOI Scopus16 WoS16 Europe PMC10
    2003 Soeller, C., Jacobs, M., Jones, K., Ellis-Davies, G., Donaldson, P., & Cannell, M. (2003). Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements (vol 8, pg 418, 2003). JOURNAL OF BIOMEDICAL OPTICS, 8(4), 668.
    DOI
    2002 Nixon, V., Levasseur, M., McDougall, A., & Jones, K. (2002). Ca<sup>2+</sup>oscillations promote APC/C-dependent cyclin B1 degradation during metaphase arrest and completion of meiosis in fertilizing mouse eggs. Current Biology, 12(9), 746-750.
    DOI Scopus110 WoS106 Europe PMC68
    2001 Swann, K., Parrington, J., & Jones, K. (2001). Potential role of a sperm-derived phospholipase C in triggering the egg-activating Ca<sup>2+</sup> signal at fertilization. Reproduction, 122(6), 839-846.
    DOI Scopus18 WoS19 Europe PMC8
    2001 Rice, A., Parrington, J., Jones, K., & Swann, K. (2001). Erratum: Mammalian sperm contain a Ca<sup>2+</sup>-sensitive phospholipase C activity that can generate InsP<inf>3</inf> from PIP<inf>2</inf> associated with intracellular organelles (Developmental Biology (2000) 228: 1 (125-135)). Developmental Biology, 239(2), 388.
    DOI
    2001 Hyslop, L., Carroll, M., Nixon, V., McDougall, A., & Jones, K. (2001). Simultaneous measurement of intracellular nitric oxide and free calcium levels in chordate eggs demonstrates that nitric oxide has no role at fertilization. Developmental Biology, 234(1), 216-230.
    DOI Scopus43 WoS43 Europe PMC24
    2000 Jones, K., Matsuda, M., Parrington, J., Katan, M., & Swann, K. (2000). Different Ca<sup>2+</sup>-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs. Biochemical Journal, 346(3), 743-749.
    DOI Scopus82 WoS75
    2000 Jones, K., & Nixon, V. (2000). Sperm-induced Ca<sup>2+</sup> oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: Evidence to support a continuous low level production of inositol 1,4,5-trisphosphate during mammalian fertilization. Developmental Biology, 225(1), 1-12.
    DOI Scopus65 WoS58 Europe PMC35
    2000 Nixon, V., McDougall, A., & Jones, K. (2000). Ca<sup>2+</sup> oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs. Biology of the Cell, 92(3-4), 187-196.
    DOI Scopus44 WoS43 Europe PMC27
    2000 Rice, A., Parrington, J., Jones, K., & Swann, K. (2000). Mammalian sperm contain a Ca<sup>2+</sup> -sensitive phospholipase C activity that can generate InsP<inf>3</inf> from PIP<inf>2</inf> associated with intracellular organelles. Developmental Biology, 228(1), 125-135.
    DOI Scopus99 WoS91 Europe PMC47
    2000 Stricker, S., Swann, K., Jones, K., & Fissore, R. (2000). Injections of porcine sperm extracts trigger fertilization-like calcium oscillations in oocytes of a marine worm. Experimental Cell Research, 257(2), 341-347.
    DOI Scopus17 WoS17 Europe PMC11
    2000 McDougall, A., Levasseur, M., O'Sullivan, A., & Jones, K. (2000). Cell cycle-dependent repetitive Ca<sup>2+</sup> waves induced by a cytosolic sperm extract in mature ascidian eggs mimic those observed at fertilization. Journal of Cell Science, 113(19), 3453-3462.
    Scopus24 WoS25 Europe PMC8
    2000 Jones, K., Matsuda, M., Parrington, J., Katan, M., & Swann, K. (2000). Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs.. The Biochemical journal, 346 Pt 3(3), 743-749.
    DOI Europe PMC34
    1999 Parrington, J., Jones, K., Lai, A., & Swann, K. (1999). The soluble sperm factor that causes Ca2+ release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca2+ oscillations after injection into mouse eggs.. The Biochemical journal, 341 ( Pt 1)(1), 1-4.
    DOI Europe PMC26
    1999 Parslew, R., Jones, K., Rhodes, J., & Sharpe, G. (1999). The antiproliferative effect of lectin from the edible mushroom (Agaricus bisporus) on human keratinocytes: Preliminary studies on its use in psoriasis. British Journal of Dermatology, 140(1), 56-60.
    DOI Scopus38 WoS28 Europe PMC12
    1999 Parrington, J., Jones, K., Lai, F., & Swann, K. (1999). The soluble sperm factor that causes Ca<sup>2+</sup> release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca<sup>2+</sup> oscillations after injection into mouse eggs. Biochemical Journal, 341(1), 1-4.
    DOI Scopus50 WoS47
    1998 Jones, K. (1998). Protein kinase C action at fertilization: Overstated or undervalued?. Reviews of Reproduction, 3(1), 7-12.
    DOI Scopus30 WoS33 Europe PMC19
    1998 Jones, K., Soeller, C., & Cannell, M. (1998). The passage of Ca<sup>2+</sup> and fluorescent markers between the sperm and egg after fusion in the mouse. Development, 125(23), 4627-4635.
    Scopus87 WoS75 Europe PMC47
    1998 Jones, K. (1998). Ca<sup>2+</sup> oscillations in the activation of the egg and development of the embryo in mammals. International Journal of Developmental Biology, 42(1), 1-10.
    Scopus100 Europe PMC57
    1998 Jones, K., Cruttwell, C., Parrington, J., & Swann, K. (1998). A mammalian sperm cytosolic phospholipase C activity generates inositol trisphosphate and causes Ca<sup>2+</sup> release in sea urchin egg homogenates. FEBS Letters, 437(3), 297-300.
    DOI Scopus110 WoS94 Europe PMC53
    1998 Swann, K., Parrington, J., & Jones, K. (1998). On the search for the sperm oscillogen. Molecular Human Reproduction, 4(11), 1010-1012.
    DOI Scopus12 WoS12
    1998 Swann, K., Parrington, J., & Jones, K. (1998). On the search for the sperm oscillogen.. Molecular human reproduction, 4(11), 1010-1012.
    DOI Europe PMC5
    1998 Jones, K. (1998). Ca2+ oscillations in the activation of the egg and development of the embryo in mammals. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 42(1), 1-10.
    WoS95
    1997 Gangeswaran, R., & Jones, K. (1997). Unique protein kinase C profile in mouse oocytes: Lack of calcium-dependent conventional isoforms suggested by rtPCR and Western blotting. FEBS Letters, 412(2), 309-312.
    DOI Scopus54 WoS56 Europe PMC39
    1997 Galione, A., Jones, K., Lai, F., & Swann, K. (1997). A cytosolic sperm protein factor mobilizes Ca<sup>2+</sup> from intracellular stores by activating multiple Ca<sup>2+</sup> release mechanisms independently of low molecular weight messengers. Journal of Biological Chemistry, 272(46), 28901-28905.
    DOI Scopus29 WoS30 Europe PMC20
    1997 Bos-Mikich, A., Whittingham, D., & Jones, K. (1997). Meiotic and mitotic Ca<sup>2+</sup> oscillations affect cell composition in resulting blastocysts. Developmental Biology, 182(1), 172-179.
    DOI Scopus170 WoS156 Europe PMC99
    1996 Kono, T., Jones, K., Bos-Mikich, A., Whittingham, D., & Carroll, J. (1996). A cell cycle-associated change in Ca<sup>2+</sup> releasing activity leads to the generation of Ca<sup>2+</sup> transients in mouse embryos during the first mitotic division. Journal of Cell Biology, 132(5), 915-923.
    DOI Scopus94 WoS92 Europe PMC57
    1996 Jones, K., & Whittingham, D. (1996). A comparison of sperm- and IP<inf>3</inf>-induced Ca<sup>2+</sup> release in activated and aging mouse oocytes. Developmental Biology, 178(2), 229-237.
    DOI Scopus64 WoS67 Europe PMC50
    1996 Carroll, J., Jones, K., & Whittingham, D. (1996). Ca<sup>2+</sup> release and the development of Ca<sup>2+</sup> release mechanisms during oocyte maturation: A prelude to fertilization. Reviews of Reproduction, 1(3), 137-143.
    DOI Scopus79 Europe PMC37
    1995 McGovern, U., Jones, K., & Sharpe, G. (1995). Intracellular calcium as a second messenger following growth stimulation of human keratinocytes. British Journal of Dermatology, 132(6), 892-896.
    DOI Scopus29 WoS28 Europe PMC16
    1995 Jones, K., Carroll, J., & Whittingham, D. (1995). Ionomycin, thapsigargin, ryanodine, and sperm induced Ca<sup>2+</sup> release increase during meiotic maturation of mouse oocytes. Journal of Biological Chemistry, 270(12), 6671-6677.
    DOI Scopus158 WoS151 Europe PMC100
    1995 Carsberg, C., Jones, K., Sharpe, G., & Friedmann, P. (1995). Intracellular calcium modulates the responses of human melanocytes to melanogenic stimuli. Journal of Dermatological Science, 9(3), 157-164.
    DOI Scopus10 WoS7 Europe PMC5
    1995 Jones, K., Carroll, J., Merriman, J., Whittingham, D., & Kono, T. (1995). Repetitive sperm-induced Ca<sup>2+</sup> transients in mouse oocytes are cell cycle dependent. Development, 121(10), 3259-3266.
    Scopus153 WoS151 Europe PMC90
    1994 Jones, K., & Sharpe, G. (1994). Proliferating cell nuclear antigen decreases in normal human keratinocytes with differentiation stimuli but not in an HPV immortalised cell line. Acta Dermato-Venereologica, 74(4), 241-244.
    DOI Scopus7 WoS7 Europe PMC2
    1994 Jones, K., & Sharpe, G. (1994). Ni<sup>2+</sup> blocks the Ca<sup>2+</sup> influx in human keratinocytes following a rise in extracellular Ca<sup>2+</sup>. Experimental Cell Research, 212(2), 409-413.
    DOI Scopus25 WoS26 Europe PMC16
    1994 Jones, K., & Sharpe, G. (1994). Thapsigargin raises intracellular free calcium levels in human keratinocytes and inhibits the coordinated expression of differentiation markers. Experimental Cell Research, 210(1), 71-76.
    DOI Scopus46 WoS47 Europe PMC33
    1994 Jones, K., & Sharpe, G. (1994). Staurosporine, a non‐specific PKC inhibitor, induces keratinocyte differentiation and raises intracellular calcium, but Ro31–8220, a specific inhibitor, does not. Journal of Cellular Physiology, 159(2), 324-330.
    DOI Scopus31 WoS33 Europe PMC19
    1994 Jones, K., & Sharpe, G. (1994). Intracellular free calcium and growth changes in single human keratinocytes in response to vitamin D and five 20-epi-analogues. Archives of Dermatological Research, 286(2), 123-129.
    DOI Scopus28 WoS28 Europe PMC20

  • Book Chapters
    Year Citation
    2017 Lane, S., Crouch, S., & Jones, K. (2017). Imaging chromosome separation in mouse oocytes by responsive 3D confocal timelapse microscopy. In D. T. Stuart (Ed.), Methods in Molecular Biology (Vol. 1471, pp. 245-254).
    DOI Scopus3 Europe PMC3

  • Conference Papers
    Year Citation
    2009 Jones, K. T., Weaver, J., & Holt, J. E. (2009). The Mechanism by Which Fizzy-Related (Fzr1) Controls Pro-phase 1 Arrest in Mouse Oocytes.. In BIOLOGY OF REPRODUCTION (pp. 87). Pittsburgh, PA: SOC STUDY REPRODUCTION.
    WoS1
    2002 Hyslop, L., McDougall, A., & Jones, K. (2002). Identification of a novel delta-like human phospholipase C, which triggers Ca2+ oscillations in mammalian eggs. In MOLECULAR BIOLOGY OF THE CELL Vol. 13 (pp. 110A). SAN FRANCISCO, CALIFORNIA: AMER SOC CELL BIOLOGY.
    1994 JONES, K., & SHARPE, G. (1994). PROTEIN-KINASE-C ACTIVATION IS REQUIRED FOR KERATINOCYTE DIFFERENTIATION. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 103 (pp. 398). BLACKWELL SCIENCE INC.
    1993 SHARPE, G., & JONES, K. (1993). THAPSIGARGIN INDUCES GROWTH-INHIBITION OF HUMAN KERATINOCYTES BY DEPLETION OF INTRACELLULAR CALCIUM STORES. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 100 (pp. 469). BLACKWELL SCIENCE INC.
    1993 JONES, K., VOUSDEN, K., & SHARPE, G. (1993). THE EFFECT OF STAUROSPORINE ON NORMAL HUMAN KERATINOCYTES AND IMMORTAL HUMAN PAPILLOMA-VIRUS TRANSFORMED-CELLS. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 100 (pp. 440). BLACKWELL SCIENCE INC.
    WoS1
    1992 JONES, K., & SHARPE, G. (1992). INTRACELLULAR PH CHANGES IN NORMAL HUMAN KERATINOCYTES. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 98 (pp. 530). BLACKWELL PUBLISHING INC.

  • Current Higher Degree by Research Supervision (University of Adelaide)
    Date Role Research Topic Program Degree Type Student Load Student Name
    2018 Co-Supervisor Evolution and Organization of Monotreme Sex Chromosomes Doctor of Philosophy Doctorate Full Time Mr Filip Pajpach
    2018 Principal Supervisor Meiotic Drive and Chromosome Segregation Doctor of Philosophy Doctorate Full Time Mr Feng Tang

  • Editorial Boards
    Date Role Editorial Board Name Institution Country
    2019 - 2021 Editor-In-chief Molecular Human Reproduction ESHRE United Kingdom

  • Review, Assessment, Editorial and Advice
    Date Title Type Institution Country
    2017 - 2018 Genes, Development and STEM approaches to Biology — Biotechnology and Biological Sciences Research Council United Kingdom
    2015 - 2016 BBSRC Pool of Experts Peer Review Biotechnology and Biological Sciences Research Council United Kingdom
    2011 - 2012 Research Evaluation Committee ERA2012 Peer Review Australian Research Council Australia
    2010 - ongoing Faculty of 1000 Peer Review Faculty of 1000 United Kingdom
    2009 - 2012 ARC College of Experts Grant Assessment Australian Research Council Australia
  • Position: Executive Dean, Faculty of Sciences
  • Phone: 83135650
  • Email: keith.jones@adelaide.edu.au
  • Campus: North Terrace
  • Building: Darling, floor G
  • Org Unit: Faculty of Sciences
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