
Dr Katherine Morel
Postdoctoral Researcher - SAiGENCI
South Australian Immunogenomics Cancer Institute
Faculty of Health and Medical Sciences
Dr. Katherine Morel is a Research Fellow in the South Australian Immunogenomics Cancer Institute (SAiGENCI) and Dame Roma Mitchell Cancer Research Laboratories (DRMCRL) at the University of Adelaide. in 2017, Dr. Morel was awarded her PhD from Flinders University in Adelaide, South Australia. Her doctoral research was carried out under the supervision of Prof. Pamela Sykes and focused on investigating the use of the anti-inflammatory compound parthenolide in the treatment and prevention of prostate cancer. Following the completion of her PhD studies, Dr. Morel continued her training as a Postdoctoral Research Fellow at the Dana-Farber Cancer Institute (DFCI), Harvard University in Boston, Massachusetts. At DFCI, Dr. Morel's research interests focused on genetic drivers of aggressive prostate cancer and identifying and utilising novel therapeutic approaches to target these genetic perturbations. This research utilised unique GEM and 3D organoid models of prostate cancer together with the latest techniques in genomics and proteomics. In 2022, Dr. Morel returned to Adelaide to continue her research into prostate cancer at the University of Adelaide.
-
Appointments
Date Position Institution name 2018 - 2021 Postdoctoral Research Fellow Dana–Farber Cancer Institute, Harvard University -
Education
Date Institution name Country Title 2013 - 2017 Flinders University Australia PhD 2011 - 2011 Flinders University Australia BSc (Hons) 2007 - 2010 Flinders University Australia BMSc -
Research Interests
-
Journals
Year Citation 2021 Morel, K. L., Sheahan, A. V., Burkhart, D. L., Baca, S. C., Boufaied, N., Liu, Y., . . . Ellis, L. (2021). EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Nature Cancer, 2(4), 444-456.
Scopus28 WoS24 Europe PMC242021 Morel, K. L., Hamid, A. A., Clohessy, J. G., Pandell, N., Ellis, L., & Sweeney, C. J. (2021). NF-κB blockade with oral administration of dimethylaminoparthenolide, delays prostate cancer resistance to androgen receptor inhibition and inhibits AR variants. Mol Cancer Res, 19(7), 1137-1145.
2020 Burkhart, D. L., Morel, K. L., Wadosky, K. M., Labbe, D. P., Galbo, P. M., Dalimov, Z., . . . Ellis, L. (2020). Evidence that EZH2 deregulation is an actionable therapeutic target for prevention of prostate cancer. Cancer Prevention Research, 13(12), 979-988.
Scopus1 WoS1 Europe PMC12020 VanDeusen, H. R., Ramroop, J. R., Morel, K. L., Bae, S. Y., Sheahan, A. V., Sychev, Z., . . . Drake, J. M. (2020). Targeting RET kinase in neuroendocrine prostate cancer. Molecular Cancer Research, 18(8), 1176-1188.
Scopus12 WoS12 Europe PMC102019 Tran, L. N. K., Kichenadasse, G., Morel, K. L., Lavranos, T. C., Klebe, S., Lower, K. M., . . . Sykes, P. J. (2019). The combination of metformin and valproic acid has a greater anti-tumoral effect on prostate cancer growth in vivo than either drug alone. In Vivo, 33(1), 99-108.
Scopus7 Europe PMC42019 Morel, K. L., Ormsby, R. J., Klebe, S., Sweeney, C. J., & Sykes, P. J. (2019). DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo. Radiation research, 192(2), 231-239.
Scopus4 WoS5 Europe PMC22018 Morel, K. L., Ormsby, R. J., Solly, E. L., Tran, L. N. K., Sweeney, C. J., Klebe, S., . . . Sykes, P. J. (2018). Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide. Clinical and Experimental Metastasis, 35(7), 649-661.
Scopus4 WoS5 Europe PMC32017 Morel, K. L., Ormsby, R. J., Bezak, E., Sweeney, C. J., & Sykes, P. J. (2017). Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues in Vivo. Radiation Research, 187(5), 501-512.
Scopus23 WoS24 Europe PMC132017 Tran, L., Kichenadasse, G., Butler, L., Centenera, M., Morel, K., Ormsby, R., . . . Sykes, P. (2017). The combination of metformin and valproic acid induces synergistic apoptosis in the presence of p53 and androgen signaling in prostate cancer. Molecular cancer therapeutics, 16(12), 2689-2700.
Scopus21 WoS19 Europe PMC112014 Newman, M., Sykes, P., Blyth, B., Bezak, E., Lawrence, M., Morel, K., & Ormsby, R. (2014). A single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinally. PLoS One, 9(3), e93016-1-e93016-10.
Scopus11 WoS10 Europe PMC72014 Newman, M., Sykes, P., Blyth, B., Bezak, E., Lawrence, M., Morel, K., & Ormsby, R. (2014). The methylation of DNA repeat elements is sex-dependent and temporally different in response to X radiation in radiosensitive and radioresistant mouse strains. Radiation Research, 181(1), 65-75.
Scopus15 WoS15 Europe PMC14 -
Book Chapters
Year Citation 2019 Burkhart, D. L., Morel, K. L., Sheahan, A. V., Richards, Z. A., & Ellis, L. (2019). The Role of RB in Prostate Cancer Progression. In S. M. Dehm, & D. J. Tindall (Eds.), Advances in Experimental Medicine and Biology (Vol. 1210, pp. 301-318). SPRINGER INTERNATIONAL PUBLISHING AG.
Scopus7 WoS6 Europe PMC2 -
Conference Papers
Year Citation 2019 Hamid, A., Werner, L., Huang, Y., Vicier, C., Morel, K., Ellis, L., & Sweeney, C. (2019). Prognostic impact of tristetraprolin (TTP) and PTEN loss and assessment of associated immune infiltrates in localized prostate cancer (PrCa).. In JOURNAL OF CLINICAL ONCOLOGY Vol. 37 (pp. 2 pages). Chicago, IL: AMER SOC CLINICAL ONCOLOGY.
2017 Tran, L. N. K., Kichenadasse, G., Ormsby, R. J., Morel, K. L., Butler, L. M., Centenera, M. M., & Sykes, P. J. (2017). COMBINATION OF METFORMIN AND SODIUM VALPROATE FOR PROSTATE CANCER: A RAPID APPROACH FROM BENCH TO CLINICAL TRIAL.. In JOURNAL OF UROLOGY Vol. 197 (pp. E1108-E1109). Boston, MA: ELSEVIER SCIENCE INC.
2016 Tran, L. N. K., Kichenadasse, G., Morel, K. L., Ormsby, R. J., Butler, L. M., Centenera, M. M., & Sykes, P. J. (2016). Combination of metformin and valproic acid in personalized prostate cancer treatment: the role of p53 and androgen receptor signaling. In CANCER RESEARCH Vol. 76 (pp. 4 pages). New Orleans, LA: AMER ASSOC CANCER RESEARCH. 2013 Morel, K., Ormsby, R., Bezak, E., Tilley, W., Lawrence, M., & Sykes, P. (2013). Parthenolide as a selective radiosensitiser in the treatment and prevention of prostate cancer. In BJU International Vol. 112 (pp. 45). Melbourne: Wiley.
Connect With Me
External Profiles