2023 |
Salaemae, W., Thompson, A., Gaiser, B., Lee, K. J., Huxley, M., Sumby, C., . . . Wegener, K. (2023). Fortuitous<i>in vitro</i>compound degradation produces a tractable hit against<i>Mycobacterium tuberculosis</i>dethiobiotin synthetase: a cautionary tale of what goes in, does not always come out. DOI |
2023 |
Pantong, W., Pederick, J. L., Maenpuen, S., Tinikul, R., Jayapalan, J. J., Jovcevski, B., . . . Salaemae, W. (2023). Biochemical and Structural Characterization of Meningococcal Methylenetetrahydrofolate Reductase. Protein Science, 32(6), e4654-1-e4654-13. DOI Scopus1 Europe PMC2 |
2023 |
Salaemae, W., Thompson, A. P., Gaiser, B. I., Lee, K. J., Huxley, M. T., Sumby, C. J., . . . Wegener, K. L. (2023). Fortuitous <i>In Vitro</i> Compound Degradation Produces a Tractable Hit against <i>Mycobacterium tuberculosis</i> Dethiobiotin Synthetase: A Cautionary Tale of What Goes In Does Not Always Come Out. ACS Chemical Biology, 18(9), 1985-1992. DOI |
2021 |
Schumann, N. C., Lee, K. J., Thompson, A. P., Salaemae, W., Pederick, J. L., Avery, T., . . . Abell, A. D. (2021). Inhibition of Mycobacterium tuberculosis dethiobiotin synthase (MtDTBS): toward next-generation antituberculosis agents. ACS Chemical Biology, 16(11), 2339-2347. DOI Scopus7 WoS3 Europe PMC5 |
2020 |
Horsley, J. R., Jovcevski, B., Wegener, K. L., Yu, J., Pukala, T. L., & Abell, A. (2020). Rationally Designed Peptide-Based Inhibitor of Aβ42 Fibril Formation and Toxicity: A Potential Therapeutic Strategy for Alzheimer's Disease.. Biochem J, 477(11), 2039-2054. DOI Scopus25 WoS30 Europe PMC23 |
2020 |
Horsfall, A. J., Dunning, K. R., Keeling, K. L., Scanlon, D. B., Wegener, K. L., & Abell, A. D. (2020). A bimane‐based peptide staple for combined helical induction and fluorescent imaging. ChemBioChem, 21(23), 1-11. DOI Scopus9 WoS6 Europe PMC4 |
2020 |
Sternicki, L. M., Nguyen, S., Pacholarz, K. J., Barran, P., Pendini, N. R., Booker, G. W., . . . Polyak, S. W. (2020). Biochemical characterisation of class III biotin protein ligases from Botrytis cinerea and Zymoseptoria tritici. Archives of Biochemistry and Biophysics, 691, 108509-1-108509-11. DOI Scopus2 WoS1 |
2018 |
Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D., & Bruning, J. B. (2018). Front Cover: Rational Design of a 3<sub>10</sub>‐Helical PIP‐Box Mimetic Targeting PCNA, the Human Sliding Clamp (Chem. Eur. J. 44/2018). Chemistry – A European Journal, 24(44), 11234. DOI |
2018 |
Wegener, K. L., McGrath, A. E., Dixon, N. E., Oakley, A. J., Scanlon, D. B., Abell, A. D., & Bruning, J. (2018). Rational design of a 310-helical PIP-box mimetic targeting PCNA - the human sliding clamp. Chemistry - A European Journal, 24(44), 11325-11331. DOI Scopus16 WoS10 Europe PMC7 |
2018 |
Horsley, J. R., Yu, J., Wegener, K. L., Hoppmann, C., Rück-Braun, K., & Abell, A. D. (2018). Photoswitchable peptide-based ‘on-off’ biosensor for electrochemical detection and control of protein-protein interactions. Biosensors and Bioelectronics, 118, 188-194. DOI Scopus22 WoS16 Europe PMC3 |
2018 |
Thompson, A., Wegener, K., Booker, G., Polyak, S., & Bruning, J. (2018). Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase. Acta Crystallographica Section D: Structural Biology, 74(10), 965-972. DOI Scopus4 WoS4 Europe PMC1 |
2018 |
Thompson, A. P., Salaemae, W., Pederick, J. L., Abell, A. D., Booker, G. W., Bruning, J. B., . . . Polyak, S. W. (2018). Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. ACS Catalysis, 8(11), 10774-10783. DOI Scopus7 WoS5 |
2017 |
Marshall, A., Kroker, A., Murray, L., Gronthos, K., Rajapaksha, H., Wegener, K., & Bruning, J. (2017). Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21. FEBS Journal, 284(6), 985-1002. DOI Scopus11 WoS9 Europe PMC7 |
2017 |
Sternicki, L., Wegener, K., Bruning, J., Booker, G., & Polyak, S. (2017). Mechanisms governing precise protein biotinylation. Trends in Biochemical Sciences, 42(5), 383-394. DOI Scopus20 WoS17 Europe PMC8 |
2017 |
Rajapaksha, H., Bhatia, H., Wegener, K., Petrovsky, N., & Bruning, J. (2017). X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs. Biochimica et Biophysica Acta - General Subjects, 1861(8), 1981-1991. DOI Scopus17 WoS16 Europe PMC5 |
2016 |
Thompson, A. P., Sternicki, L. M., Wegener, K. L., Lu, W., Zhu, L., Booker, G. W., . . . Li, Y. (2016). Biotin Biology as a Target for New Anti-Tuberculosis Drugs. Jiangsu Journal of Preventive Medicine, 27(3), 257-261. DOI |
2016 |
Keeling, K., Cho, O., Scanlon, D., Booker, G., Abell, A., & Wegener, K. (2016). The key position: influence of staple location on constrained peptide conformation and binding. Organic & Biomolecular Chemistry, 14(41), 9731-9735. DOI Scopus7 WoS6 Europe PMC4 |
2015 |
Salaemae, W., Yap, M., Wegener, K., Booker, G., Wilce, M., & Polyak, S. (2015). Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase. Tuberculosis, 95(3), 259-266. DOI Scopus17 WoS12 Europe PMC7 |
2010 |
Anthis, N., Wegener, K., Critchley, D., & Campbell, I. (2010). Structural diversity in integrin/talin interactions. Structure, 18(12), 1654-1666. DOI Scopus76 WoS71 Europe PMC66 |
2010 |
Kalli, A., Wegener, K., Goult, B., Anthis, N., Campbell, I., & Sansom, M. (2010). The structure of the talin/integrin complex at a lipid bilayer: an NMR and MD simulation study. Structure, 18(10), 1280-1288. DOI Scopus55 WoS51 Europe PMC47 |
2009 |
Goult, B., Bate, N., Anthis, N., Wegener, K., Gingras, A., Patel, B., . . . Critchley, D. (2009). The structure of an interdomain complex that regulates talin activity. Journal of Biological Chemistry, 284(22), 15097-15106. DOI Scopus108 WoS97 Europe PMC90 |
2009 |
Anthis, N., Wegener, K., Ye, F., Kim, C., Goult, B., Lowe, E., . . . Campbell, I. (2009). The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO Journal, 28(22), 3623-3632. DOI Scopus262 WoS251 Europe PMC226 |
2009 |
Anthis, N., Haling, J., Oxley, C., Memo, M., Wegener, K., Lim, C., . . . Campbell, I. (2009). β integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. Journal of Biological Chemistry, 284(52), 36700-36710. DOI Scopus102 WoS97 Europe PMC83 |
2008 |
Wegener, K., Basran, J., Bagshaw, C., Campbell, I., Roberts, G., Critchley, D., & Barsukov, I. (2008). Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain. Journal of Molecular Biology, 382(1), 112-126. DOI Scopus44 WoS42 Europe PMC34 |
2008 |
Wegener, K., & Campbell, I. (2008). Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions. Molecular Membrane Biology, 25(5), 376-387. DOI Scopus103 WoS92 Europe PMC69 |
2008 |
Oxley, C., Anthis, N., Lowe, E., Vakonakis, I., Campbell, I., & Wegener, K. (2008). An integrin phosphorylation switch the effect of β3 integrin tail phosphorylation on dok1 and talin binding. Journal of Biological Chemistry, 283(9), 5420-5426. DOI Scopus93 WoS92 Europe PMC76 |
2007 |
Wegener, K. L., Partridge, A. W., Han, J., Pickford, A. R., Liddington, R. C., Ginsberg, M. H., & Campbell, I. D. (2007). Structural Basis of Integrin Activation by Talin. Cell, 128(1), 171-182. DOI Scopus554 WoS520 Europe PMC430 |
2006 |
Kiema, T., Lad, Y., Jiang, P., Oxley, C., Baldassarre, M., Wegener, K., . . . Calderwood, D. (2006). The molecular basis of filamin binding to integrins and competition with talin. Molecular Cell, 21(3), 337-347. DOI Scopus342 WoS319 Europe PMC277 |
2005 |
de Pereda, J., Wegener, K., Santelli, E., Bate, N., Ginsberg, M., Critchley, D., . . . Liddington, R. (2005). Structural basis for phosphatidylinositol phosphate kinaseType Iγ binding to talin at focal adhesions. Journal of Biological Chemistry, 280(9), 8381-8386. DOI Scopus70 WoS66 Europe PMC59 |
2003 |
Brinkworth, C., Carver, J., Wegener, K., Doyle, J., Llewellyn, L., & Bowie, J. (2003). The solution structure of frenatin 3, a neuronal nitric oxide synthase inhibitor from the giant tree frog, Litoria infrafrenata. Biopolymers, 70(3), 424-434. DOI Scopus13 WoS12 Europe PMC5 |
2003 |
Doyle, J., Brinkworth, C., Wegener, K., Carver, J., Llewellyn, L., Olver, I., . . . Tyler, M. (2003). nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. FEBS Journal, 270(6), 1141-1153. DOI Scopus79 WoS66 Europe PMC48 |
2003 |
Marcotte, I., Wegener, K., Lam, Y., Chia, C., de Planque, M., Bowie, J., . . . Separovic, F. (2003). Interaction of antimicrobial peptides from Australian amphibians with lipid membranes. Chemistry and Physics of Lipids, 122(1-2), 107-120. DOI Scopus130 WoS128 Europe PMC64 |
2003 |
Wegener, K., Carver, J., & Bowie, J. (2003). The solution structures and activity of caerin 1.1 and caerin 1.4 in aqueous trifluoroethanol and dodecylphosphocholine micelles. Biopolymers, 69(1), 42-59. DOI Scopus15 WoS15 Europe PMC7 |
2002 |
Doyle, J., Llewellyn, L., Brinkworth, C., Bowie, J., Wegener, K., Rozek, T., . . . Tyler, M. (2002). Amphibian peptides that inhibit neuronal nitric oxide synthase - The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri. FEBS Journal, 269(1), 100-109. DOI Scopus55 WoS54 Europe PMC30 |
2001 |
Wegener, K., Brinkworth, C., Bowie, J., Wallace, J., & Tyler, M. (2001). Bioactive dahlein peptides from the skin secretions of the Australian aquatic frog Litoria dahlii: sequence determination by electrospray mass spectrometry. Rapid Communications in Mass Spectrometry, 15(18), 1726-1734. DOI Scopus34 WoS32 Europe PMC21 |
2000 |
Lambert, S., Seater, J., Wegener, K., Woodhouse, S., Lincoln, S., & Ward, A. (2000). A preparative, spectroscopic and equilibrium study of some phenyl-2-thiazoline fluorophores for aluminium(III) detection. New Journal of Chemistry, 24(7), 541-546. DOI Scopus12 WoS10 |
2000 |
Rozek, T., Wegener, K., Bowie, J., Olver, I., Carver, J., Wallace, J., & Tyler, M. (2000). The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis: The solution structure of aurein 1.2. FEBS Journal, 267(17), 5330-5341. DOI Scopus268 WoS231 Europe PMC140 |
1999 |
Bowie, J., Wegener, K., Chia, B., Wabnitz, P., Carver, J., Tyler, M., & Wallace, J. (1999). Host defence antibacterial peptides from skin secretions of Australian amphibians. The relationship between structure and activity. Protein and Peptide Letters, 6(5), 259-269. Scopus40 WoS35 |
1999 |
Wegener, K., Wabnitz, P., Carver, J., Bowie, J., Chia, B., Wallace, J., & Tyler, M. (1999). Host defence peptides from the skin glands of the Australian Blue Mountains tree-frog Litoria citropa. European Journal of Biochemistry, 265(2), 627-637. DOI Scopus84 WoS76 Europe PMC43 |