
Kate Secombe
School of Biomedicine
Faculty of Health and Medical Sciences
Kate completed her PhD in the Cancer Treatment Toxicities Group in 2021, investigating the role of the gut microbiome in the development of cancer treatment-induced gastrointestinal injury. She is currently an Adjunct Associate Lecturer in the School of Biomedicine at the University of Adelaide.
My research is focussed on understanding the role of the gut microbiome in the development of gastrointestinal toxicity following cancer treatment. I am also working to understand the interactions between the gut microbiome and the innate immune system in developing this toxicity.
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Appointments
Date Position Institution name 2014 - 2016 Technical Assistant University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2021 Award South Australian Young Achiever in STEM Awards Australia Australia 2020 Award Young Scientist, 70th Lindau Nobel Laureate Meeting Australian Academy of Science Australia 2020 Fellowship Adam J Berry Fellowship Awardee Australian Academy of Science and National Insititutes of Health (USA) United States 2019 Award Outstanding Community Presentation, RAHsearch Showcase Royal Adelaide Hospital Australia 2019 Award CSIRO ON Pitch Competition, 2nd place CSIRO Australia 2019 Honour Falling Walls Australia, 2nd place Australian Academy of Science Australia 2018 Award Hans-Jürgen and Maria Ohff Research Grant University of Adelaide Australia 2017 Scholarship Lions Medical Research Foundation Inc Scholarship The University of Adelaide 2017 Award Lions Medical Research Foundation Inc Travel Grant 2017 Scholarship Research Training Program Stipend University of Adelaide Australia 2014 Achievement Highest Honours Grade 2014 Achievement Best Honours Poster Presentation 2013 Award Faculty of Sciences Outstanding Academic Achievement 2012 Award Faculty of Sciences Outstanding Academic Achievement -
Education
Date Institution name Country Title 2017 - 2021 University of Adelaide Australia PhD in Medicine 2014 - 2014 University of Adelaide Australia Bachelor of Health Sciences (Honours) 2010 - 2014 University of Adelaide Australia Bachelor of Science (Biomedical Science)
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Journals
Year Citation 2021 Secombe, K. R., Ball, I. A., Shirren, J., Wignall, A. D., Keefe, D. M., & Bowen, J. M. (2021). Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.. Breast Cancer, 28(1), 99-109.
Scopus2 WoS1 Europe PMC12021 Secombe, K. R., Crame, E. E., Tam, S. Y. J., Wardill, H. R., Gibson, R. J., Coller, J. K., & Bowen, J. M. (2021). Intestinal toll-like receptor 4 knockout alters the functional capacity of the gut microbiome following irinotecan treatment.. Cancer Chemother Pharmacol, 89(2), 275-281.
2021 Secombe, K. R., Al-Qadami, G. H., Subramaniam, C. B., Bowen, J. M., Scott, J., Van Sebille, Y. Z. A., . . . Wardill, H. R. (2021). Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols. Gut Microbes, 13(1), 1979878-1-1979878-15.
Scopus7 WoS7 Europe PMC32021 Crame, E. E., Bowen, J. M., Secombe, K. R., Coller, J. K., François, M., Leifert, W., & Wardill, H. R. (2021). Epithelial-Specific TLR4 Knockout Challenges Current Evidence of TLR4 Homeostatic Control of Gut Permeability. Inflammatory Intestinal Diseases, 6(4), 1-11.
Scopus12020 Secombe, K. R., Van Sebille, Y. Z. A., Mayo, B. J., Coller, J. K., Gibson, R. J., & Bowen, J. M. (2020). Diarrhea Induced by Small Molecule Tyrosine Kinase Inhibitors Compared With Chemotherapy: Potential Role of the Microbiome.. Integr Cancer Ther, 19, 1534735420928493.
Scopus11 WoS8 Europe PMC72020 Mayo, B., Secombe, K., Wignall, A., Bateman, E., Thorpe, D., Pietra, C., . . . Bowen, J. (2020). The GLP-2 Analogue Elsiglutide Reduces Diarrhoea Caused by the Tyrosine Kinase Inhibitor Lapatinib in Rats. Cancer Chemotherapy and Pharmacology, 85(4), 793-803.
Scopus7 WoS6 Europe PMC42019 Secombe, K. R., Coller, J. K., Gibson, R. J., Wardill, H. R., & Bowen, J. M. (2019). The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity. International Journal of Cancer, 144(10), 2365-2376.
Scopus23 WoS25 Europe PMC142019 Secombe, K., Ball, I., Shirren, J., Wignall, A., Finnie, J., Keefe, D., . . . Bowen, J. (2019). Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model. Cancer Chemotherapy and Pharmacology, 83(3), 531-543.
Scopus8 WoS6 Europe PMC52019 Wardill, H., Secombe, K., Bryant, R., Hazenberg, M., & Costello, S. (2019). Adjunctive fecal microbiota transplantation in supportive oncology: emerging indications and considerations in immunocompromised patients. EBioMedicine, 44, 730-740.
Scopus29 WoS27 Europe PMC162017 Coller, J., Bowen, J., Ball, I., Wardill, H., Van Sebille, Y., Stansborough, R., . . . Gibson, R. (2017). Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report. Cancer Chemotherapy and Pharmacology, 79(2), 431-434.
Scopus7 WoS6 Europe PMC32017 Van Sebille, Y., Gibson, R., Wardill, H., Secombe, K., Ball, I., Keefe, D., . . . Bowen, J. (2017). Dacomitinib-induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats. International Journal of Cancer, 140(12), 2820-2829.
Scopus17 WoS15 Europe PMC132016 Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Logan, R., & Bowen, J. (2016). A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options. Experimental Biology and Medicine, 241(13), 1386-1394.
Scopus7 WoS7 Europe PMC52016 Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Coller, J., White, I., . . . Bowen, J. (2016). Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics, 15(6), 1376-1386.
Scopus69 WoS65 Europe PMC372016 Wardill, H., Bowen, J., Van Sebille, Y., Secombe, K., Coller, J., Ball, I., . . . Gibson, R. (2016). TLR4-dependent claudin-1 internalization and secretagogue-mediated chloride secretion regulate irinotecan-induced diarrhea. Molecular Cancer Therapeutics, 15(11), 2767-2779.
Scopus25 WoS25 Europe PMC12 -
Conference Papers
Year Citation 2021 Secombe, K. R., Ball, I. A., Wignall, A. D., Bateman, E., Diala, I., Lalani, A. S., & Bowen, J. M. (2021). Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats.. In CANCER RESEARCH Vol. 81 (pp. 2 pages). United States: AMER ASSOC CANCER RESEARCH.
2021 Al-Qadami, G., Bowen, J., Van Sebille, Y., Wardill, H., Secombe, K., & Le, H. (2021). Pre-treatment gut microbiome and radiotherapy response and toxicities among patients with head and neck cancer. In MASCC/ISOO Annual Meeting. 2021 Crame, E., Wardill, H. R., Secombe, K., Coller, J., & Bowen, J. (2021). Intestinal epithelial TLR4 are crucial to chemotherapy toxicity development. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 17 (pp. 110). WILEY. 2021 Secombe, K., Ball, I., Subramaniam, C., Al-Qadami, G., Bowen, J., & Wardill, H. R. (2021). Using patient-reported outcome measures to determine the role of the microbiome in cancer treatment-induced diarrhoea. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 17 (pp. 174-175). WILEY. 2019 Bowen, J. M., Secombe, K. R., Ball, I. A., Shirren, J., Wignall, A. D., Finnie, J. W., . . . Keefe, D. (2019). Budesonide and colesevelam reduce neratinib-induced diarrhea in a rat model. In CANCER RESEARCH Vol. 79 (pp. 2 pages). San Antonio, TX: AMER ASSOC CANCER RESEARCH.
2019 Bruning, E., Coller, J., Wardill, H., Secombe, K., & Bowen, J. (2019). Toll-like receptor 4 humanized C57BL/6 mouse intestinal permeability: A translational model for cancer treatment toxicity. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol. 34 (pp. 166). WILEY. 2019 Secombe, K., Bowen, J., Ball, I., Shirren, J., Wignall, A., Lalani, A., & Diala, I. (2019). The gut microbiome as an intervention target for neratinib-induced diarrhoea. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 15 (pp. 107-108). WILEY. 2018 Wardill, H., Secombe, K., Gibson, R., Stringer, A., Al-Dasooqi, N., Mayo, B., & Bowen, J. (2018). Pre-treatment blautia abundance regulates chemo-toxicity in colorectal cancer patients: A pilot study. In NEUROGASTROENTEROLOGY AND MOTILITY Vol. 30 (pp. 1 page). WILEY. 2018 Secombe, K., Bowen, J., Coller, J., Gibson, R., Stringer, A., Al-Dasooqi, N., . . . Wardill, H. R. (2018). Pre-treatment Blautia abundance regulates chemotherapy-induced gastrointestinal toxicity risk: a pilot study. In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Vol. 14 (pp. 59). WILEY.
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Conference Items
Year Citation 2017 Secombe, K. R., Ball, I. A., Shirren, J., Wignall, A. D., Wardill, H. R., Van Sebille, Y. Z. A., & Bowen, J. M. (2017). Budesonide Reduces Neratinib-Induced Gastrointestinal Injury and Diarrhoea in Rats. Poster session presented at the meeting of ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY. WILEY.
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Datasets
Year Citation Secombe, K. (n.d.). GRAFT systematic review data.
Practical Demonstrator
Physiology IIA and IIB
Human Anatomy and Physiology IB
Teaching Assistant
Precision Medicine
Guest Lecturer
Integrative Cell Biology
Biology of Disease II
Online Tutor
Foundations of Human Biology, University of South Australia
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Memberships
Date Role Membership Country 2016 - ongoing Member Multinational Association for Supportive Care in Cancer 2014 - ongoing Member Australian Society of Medical Research 2013 - ongoing Board Member Faculty of Sciences Board 2011 - ongoing Golden Key International Honour Society
Connect With Me
External Profiles