Kate Secombe
Higher Degree by Research Candidate
Adelaide Medical School
Faculty of Health and Medical Sciences
Kate is a PhD candidate in the Cancer Treatment Toxicities Group, supervised by A/Prof Joanne Bowen, Dr Janet Coller and Prof Rachel Gibson. She is investigating chemotherapy-induced gastrointestinal injury.
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Appointments
Date Position Institution name 2014 - 2016 Technical Assistant University of Adelaide -
Awards and Achievements
Date Type Title Institution Name Country Amount 2018 Award Hans-Jürgen and Maria Ohff Research Grant University of Adelaide Australia — 2017 Scholarship Lions Medical Research Foundation Inc Scholarship The University of Adelaide — — 2017 Award Lions Medical Research Foundation Inc Travel Grant — — — 2017 Scholarship Research Training Program Stipend — Anguilla — 2014 Achievement Highest Honours Grade — — — 2014 Achievement Best Honours Poster Presentation — — — 2013 Award Faculty of Sciences Outstanding Academic Achievement — — — 2012 Award Faculty of Sciences Outstanding Academic Achievement — — — -
Education
Date Institution name Country Title 2017 University of Adelaide Australia PhD in Medicine 2014 - 2014 University of Adelaide Australia Bachelor of Health Sciences (Honours) 2010 - 2014 University of Adelaide Australia Bachelor of Science (Biomedical Science)
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Journals
Year Citation 2019 Secombe, K., Ball, I., Shirren, J., Wignall, A., Finnie, J., Keefe, D., . . . Bowen, J. (2019). Targeting neratinib-induced diarrhea with budesonide and colesevelam in a rat model. Cancer Chemotherapy and Pharmacology, 83(3), 531-543.
2019 Wardill, H., Secombe, K., Bryant, R., Hazenberg, M., & Costello, S. (2019). Adjunctive fecal microbiota transplantation in supportive oncology: emerging indications and considerations in immunocompromised patients. EBioMedicine, 44, 730-740.
Scopus3 WoS1 Europe PMC22018 Secombe, K., Coller, J., Gibson, R., Wardill, H., & Bowen, J. (2018). The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity. International Journal of Cancer, 144(10), 2365-2376.
Scopus4 WoS3 Europe PMC12017 Van Sebille, Y., Gibson, R., Wardill, H., Secombe, K., Ball, I., Keefe, D., . . . Bowen, J. (2017). Dacomitinib-induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats. International Journal of Cancer, 140(12), 2820-2829.
Scopus8 WoS6 Europe PMC32017 Coller, J., Bowen, J., Ball, I., Wardill, H., van Sebille, Y., Stansborough, R., . . . Gibson, R. (2017). Potential safety concerns of TLR4 antagonism with irinotecan: a preclinical observational report. Cancer Chemotherapy and Pharmacology, 79(2), 431-434.
Scopus3 WoS3 Europe PMC12016 Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Logan, R., & Bowen, J. (2016). A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options. Experimental Biology and Medicine, 241(13), 1386-1394.
Scopus5 WoS6 Europe PMC32016 Wardill, H., Gibson, R., Van Sebille, Y., Secombe, K., Coller, J., White, I., . . . Bowen, J. (2016). Irinotecan-induced gastrointestinal dysfunction and pain are mediated by common TLR4-dependent mechanisms. Molecular Cancer Therapeutics, 15(6), 1376-1386.
Scopus28 WoS25 Europe PMC112016 Wardill, H., Bowen, J., Van Sebille, Y., Secombe, K., Coller, J., Ball, I., . . . Gibson, R. (2016). TLR4-dependent claudin-1 internalization and secretagogue-mediated chloride secretion regulate irinotecan-induced diarrhea. Molecular Cancer Therapeutics, 15(11), 2767-2779.
Scopus9 WoS10 Europe PMC5
Practical Demonstrator, Physiology IIA and IIB
Guest Lecturer, Integrative Cell Biology
Online Tutor, Foundations of Human Biology, University of South Australia
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Memberships
Date Role Membership Country 2016 - ongoing Member Multinational Association for Supportive Care in Cancer — 2014 - ongoing Member Australian Society of Medical Research — 2013 - ongoing Board Member Faculty of Sciences Board — 2011 - ongoing — Golden Key International Honour Society —
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External Profiles
