Kate Dredge

Dr Kate Dredge

Research Fellow

School of Pharmacy and Biomedical Sciences

College of Health

Eligible to supervise Masters and PhD - email supervisor to discuss availability.

Dr Kate Dredge has a long-standing interest in the molecular mechanisms that govern the regulation of gene expression. Her PhD research was undertaken at The Rockefeller University in New York, investigating neuron-specific alternative splicing of pre-mRNA. Never wanting to leave bench science, Dr Dredge has held several senior postdoctoral positions in Adelaide using her expertise in protein:nucleic biochemistry and molecular interaction techniques to explore post-transcriptional regulation of mRNA in development and disease, the role of microRNAs in cancer metastasis and the regulation of circRNAs. In 2023 she joined new Group Leader Dr Adrienne Sullivan to help establish the Development and Epigenetics Laboratory within the South Australian Immunogenomics and Cancer Institute (SAiGENCI) and Adelaide Centre for Epigenetics (ACE).

Using stem cells as a model, Dr Dredge is applying multi-omics approaches including ChIP-Seq, ATAC-Seq, RNA-Seq and mass spectrometry to understand the epigenetic remodelling that occurs as a cell exits pluripotency and acquires a new cell identity. In particular, she seeks to determine how enhancer activation and decommissioning drive the transcriptional programs that ultimately determine a cell’s fate and function. Understanding this process will not only shed light on normal human development but will also further our understanding of how and why things go awry during developmental disease and cancer initiation and progression.

Date Position Institution name
2023 - ongoing Senior Research Fellow (Level B, 0.6 FTE) University of Adelaide
2016 - 2023 Senior Research Fellow (Level B, 0.6 FTE) University of South Australia
2004 - 2015 Postdoctoral Fellow University of Adelaide

Date Institution name Country Title
1996 - 2002 Rockefeller University United States PhD
1992 - 1995 University of Adelaide Australia Bachelor of Science (+ Honours).

Year Citation
2025 Orang, A., Warnock, N. I., Migault, M., Dredge, B. K., Bert, A. G., Bracken, J. M., . . . Bracken, C. P. (2025). Chasing non-existent "microRNAs" in cancer. Oncogenesis, 14(1, article no. 10), 10-1-10-9.
DOI Scopus4 WoS4 Europe PMC4
2025 Pitino, E., Pascual-Reguant, A., Segato-Dezem, F., Wise, K., Salvador-Martinez, I., Crowell, H. L., . . . Martelotto, L. G. (2025). STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging.. Cell, 188(18), 5100-5117.e26.
DOI Scopus5 WoS4 Europe PMC7
2024 Liu, D., Dredge, B. K., Bert, A. G., Pillman, K. A., Toubia, J., Guo, W., . . . Goodall, G. J. (2024). ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic Acids Research, 52(3), 1387-1403.
DOI Scopus20 WoS18 Europe PMC18
2024 Neumann, D. P., Pillman, K. A., Dredge, B. K., Bert, A. G., Phillips, C. A., Lumb, R., . . . Gregory, P. A. (2024). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. RNA Biology, 21(1), 1-11.
DOI Scopus8 WoS7 Europe PMC24
2024 Ngo, L. H., Bert, A. G., Dredge, B. K., Williams, T., Murphy, V., Li, W., . . . Wickramasinghe, V. O. (2024). Nuclear export of circular RNA. Nature, 627(8002), 212-220.
DOI Scopus80 WoS73 Europe PMC68
2024 Ngo, L. H., Bert, A. G., Dredge, B. K., Williams, T., Murphy, V., Li, W., . . . Wickramasinghe, V. O. (2024). Publisher Correction: Nuclear export of circular RNA.. Nature, 627(8005), E12.
DOI
2023 Sapkota, S., Pillman, K. A., Dredge, B. K., Liu, D., Bracken, J. M., Kachooei, S. A., . . . Goodall, G. J. (2023). On the rules of engagement for microRNAs targeting protein coding regions. Nucleic Acids Research, 51(18), 9938-9951.
DOI Scopus14 WoS12 Europe PMC12
2023 Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17.
DOI Scopus4 WoS4 Europe PMC10
2022 Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., . . . Pitson, S. M. (2022). Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.. Blood, 139(26), 3737-3751.
DOI Scopus39 WoS36 Europe PMC40
2021 Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., . . . Selth, L. A. (2021). Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer. Cell Reports, 34(1), 1-17.
DOI Scopus41 WoS41 Europe PMC43
2021 Jensen, K. B., Dredge, B. K., Toubia, J., Jin, X., Iadevaia, V., Goodall, G. J., & Proud, C. G. (2021). capCLIP: a new tool to probe translational control in human cells through capture and identification of the eIF4E-mRNA interactome. Nucleic acids research, 49(18), e105.
DOI Scopus16 WoS17 Europe PMC23
2020 Jensen, K., Dredge, K., Toubia, J., Jin, X., Iadevaia, V., Goodall, G., & Proud, C. (2020). capCLIP: a new tool to probe protein synthesis in human cells through capture and identification of the eIF4E-mRNA interactome.
DOI
2020 Saunders, K., Bert, A. G., Dredge, B. K., Toubia, J., Gregory, P. A., Pillman, K. A., . . . Bracken, C. P. (2020). Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing. Scientific Reports, 10(1), 1-9.
DOI Scopus14 WoS11 Europe PMC9
2018 Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages.
DOI Scopus92 WoS91 Europe PMC85
2014 Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., . . . Goodall, G. (2014). Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. The EMBO Journal, 33(18), 1979-2134.
DOI Scopus124 WoS121 Europe PMC117
2011 Dredge, B., & Jensen, K. (2011). NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PLoS One, 6(6), e21585-1-e21585-12.
DOI Scopus85 WoS84 Europe PMC88
2011 Wiszniak, S., Dredge, B., & Jensen, K. (2011). HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL. PLoS One, 6(6), e20773-1-e20773-9.
DOI Scopus23 WoS21 Europe PMC21
2005 Dredge, B., Stefani, G., Engelhard, C., & Darnell, R. (2005). Nova autoregulation reveals dual functions in neuronal splicing. EMBO Journal, 24(8), 1608-1620.
DOI Scopus101 WoS104 Europe PMC102
2003 Dredge, B., & Darnell, R. (2003). Nova regulates GABA(A) receptor gamma 2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Molecular and Cellular Biology, 23(13), 4687-4700.
DOI Scopus102 WoS105 Europe PMC100
2001 Dredge, B., Polydorides, A., & Darnell, R. (2001). The splice of life: Alternative splicing and neurological disease. Nature Reviews. Neuroscience, 2(1), 43-50.
DOI Scopus139 WoS133 Europe PMC120
2000 Jensen, K. B., Dredge, B. K., Stefani, G., Zhong, R., Buckanovich, R. J., Okano, H. J., . . . Darnell, R. B. (2000). Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron, 25(2), 359-371.
DOI Scopus351 WoS340 Europe PMC330
1997 Stroeher, U. H., Parasivam, G., Kate Dredge, B., & Manning, P. A. (1997). Novel vibrio cholerae O139 genes involved in lipopolysaccharide biosynthesis. Journal of Bacteriology, 179(8), 2740-2747.
DOI Scopus64 WoS62 Europe PMC53
1995 Stroeher, U., Dredge, B., Morona, R., Brown, M., Karageorgos, L., Albert, M., & Manning, P. (1995). Genetic rearrangements in the rfb regions of Vibrio cholerae O1 and O139. Proceedings of the National Academy of Sciences of the United States of America, 92(22), 10374-10378.
DOI Scopus89 WoS81 Europe PMC65

Year Citation
2024 Pitino, E., Pascual-Reguant, A., Segato-Dezem, F., Wise, K., Salvador-Martinez, I., Crowell, H. L., . . . Martelotto, L. (2024). STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging.
DOI
2022 Neumann, D., Pillman, K., Dredge, K., Bert, A., Bracken, C., Hollier, B., . . . Gregory, P. (2022). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking.
DOI

 

Date Project/ No. Investigators Funding Body Amount
2012-2015 1033391 Kirk Jensen, B. Kate Dredge, David Adelson. NHMRC $588,423
2009-2011 565424 Kirk Jensen, B. Kate Dredge. NHMRC $545,217
2005-2007 DP0559550 Kirk Jensen, B. Kate Dredge. ARC $320,608

Date Role Research Topic Program Degree Type Student Load Student Name
2007 - 2011 Co-Supervisor Investigating Mechanisms of Post-transcriptional Gene Regulation in the Germ Cells of Zebrafish Doctor of Philosophy Doctorate Full Time Miss Sophie Wiszniak

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