Dr Kate Dredge

Research Fellow

School of Biomedicine

Faculty of Health and Medical Sciences

Dr Kate Dredge has a long-standing interest in the molecular mechanisms that govern the regulation of gene expression. Her PhD research was undertaken at The Rockefeller University in New York, investigating neuron-specific alternative splicing of pre-mRNA. Never wanting to leave bench science, Dr Dredge has held several senior postdoctoral positions in Adelaide using her expertise in protein:nucleic biochemistry and molecular interaction techniques to explore post-transcriptional regulation of mRNA in development and disease, the role of microRNAs in cancer metastasis and the regulation of circRNAs. In 2023 she joined new Group Leader Dr Adrienne Sullivan to help establish the Development and Epigenetics Laboratory within the South Australian Immunogenomics and Cancer Institute (SAiGENCI) and Adelaide Centre for Epigenetics (ACE).

My Research
Career
Publications
Grants and Funding
Supervision
Contact

Using stem cells as a model, Dr Dredge is applying multi-omics approaches including ChIP-Seq, ATAC-Seq, RNA-Seq and mass spectrometry to understand the epigenetic remodelling that occurs as a cell exits pluripotency and acquires a new cell identity. In particular, she seeks to determine how enhancer activation and decommissioning drive the transcriptional programs that ultimately determine a cell’s fate and function. Understanding this process will not only shed light on normal human development but will also further our understanding of how and why things go awry during developmental disease and cancer initiation and progression.

Appointments

Date	Position	Institution name
2023 - ongoing	Senior Research Fellow (Level B, 0.6 FTE)	University of Adelaide
2016 - 2023	Senior Research Fellow (Level B, 0.6 FTE)	University of South Australia
2004 - 2015	Postdoctoral Fellow	University of Adelaide

Education

Date Institution name Country Title

1996 - 2002 Rockefeller University United States PhD

1992 - 1995 University of Adelaide Australia Bachelor of Science (+ Honours).

Date	Institution name	Country	Title
1996 - 2002	Rockefeller University	United States	PhD
1992 - 1995	University of Adelaide	Australia	Bachelor of Science (+ Honours).

Journals

Year	Citation
2025	Orang, A., Warnock, N. I., Migault, M., Dredge, B. K., Bert, A. G., Bracken, J. M., . . . Bracken, C. P. (2025). Chasing non-existent "microRNAs" in cancer. Oncogenesis, 14(1), 10-1-10-9. DOI
2024	Liu, D., Dredge, B. K., Bert, A. G., Pillman, K. A., Toubia, J., Guo, W., . . . Goodall, G. J. (2024). ESRP1 controls biogenesis and function of a large abundant multiexon circRNA. Nucleic Acids Research, 52(3), 1387-1403. DOI Scopus10 Europe PMC10
2024	Neumann, D. P., Pillman, K. A., Dredge, B. K., Bert, A. G., Phillips, C. A., Lumb, R., . . . Gregory, P. A. (2024). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. RNA Biology, 21(1), 1-11. DOI Scopus6 Europe PMC12
2024	Ngo, L. H., Bert, A. G., Dredge, B. K., Williams, T., Murphy, V., Li, W., . . . Wickramasinghe, V. O. (2024). Nuclear export of circular RNA. Nature, 627(8002), 212-220. DOI Scopus47 Europe PMC31
2024	Ngo, L. H., Bert, A. G., Dredge, B. K., Williams, T., Murphy, V., Li, W., . . . Wickramasinghe, V. O. (2024). Publisher Correction: Nuclear export of circular RNA.. Nature, 627(8005), E12. DOI
2023	Sapkota, S., Pillman, K. A., Dredge, B. K., Liu, D., Bracken, J. M., Kachooei, S. A., . . . Goodall, G. J. (2023). On the rules of engagement for microRNAs targeting protein coding regions. Nucleic Acids Research, 51(18), 9938-9951. DOI Scopus9 Europe PMC8
2023	Orang, A., Dredge, B. K., Liu, C. Y., Bracken, J. M., Chen, C. -H., Sourdin, L., . . . Bracken, C. P. (2023). Basonuclin-2 regulates extracellular matrix production and degradation. Life Science Alliance, 6(10), e202301984-1-e202301984-17. DOI Scopus2 Europe PMC3
2022	Lewis, A. C., Pope, V. S., Tea, M. N., Li, M., Nwosu, G. O., Nguyen, T. M., . . . Pitson, S. M. (2022). Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.. Blood, 139(26), 3737-3751. DOI Scopus29 WoS9 Europe PMC26
2021	Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., . . . Selth, L. A. (2021). Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer. Cell Reports, 34(1), 1-17. DOI Scopus36 WoS23 Europe PMC32
2021	Jensen, K. B., Dredge, B. K., Toubia, J., Jin, X., Iadevaia, V., Goodall, G. J., & Proud, C. G. (2021). capCLIP: a new tool to probe translational control in human cells through capture and identification of the eIF4E-mRNA interactome. Nucleic acids research, 49(18), e105. DOI Scopus16 WoS7 Europe PMC18
2020	Jensen, K., Dredge, K., Toubia, J., Jin, X., Iadevaia, V., Goodall, G., & Proud, C. (2020). capCLIP: a new tool to probe protein synthesis in human cells through capture and identification of the eIF4E-mRNA interactome. DOI
2020	Saunders, K., Bert, A. G., Dredge, B. K., Toubia, J., Gregory, P. A., Pillman, K. A., . . . Bracken, C. P. (2020). Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing. Scientific Reports, 10(1), 1-9. DOI Scopus12 WoS5 Europe PMC9
2018	Pillman, K. A., Phillips, C. A., Roslan, S., Toubia, J., Dredge, B. K., Bert, A. G., . . . Gregory, P. A. (2018). miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking. EMBO Journal, 37(13), 20 pages. DOI Scopus87 WoS64 Europe PMC68
2014	Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., . . . Goodall, G. (2014). Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. The EMBO Journal, 33(18), 1979-2134. DOI Scopus123 WoS116 Europe PMC106
2011	Dredge, B., & Jensen, K. (2011). NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PLoS One, 6(6), e21585-1-e21585-12. DOI Scopus79 WoS67 Europe PMC72
2011	Wiszniak, S., Dredge, B., & Jensen, K. (2011). HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL. PLoS One, 6(6), e20773-1-e20773-9. DOI Scopus23 WoS19 Europe PMC19
2005	Dredge, B., Stefani, G., Engelhard, C., & Darnell, R. (2005). Nova autoregulation reveals dual functions in neuronal splicing. EMBO Journal, 24(8), 1608-1620. DOI Scopus96 WoS94 Europe PMC94
2003	Dredge, B., & Darnell, R. (2003). Nova regulates GABA(A) receptor gamma 2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Molecular and Cellular Biology, 23(13), 4687-4700. DOI Scopus97 WoS97 Europe PMC90
2001	Dredge, B., Polydorides, A., & Darnell, R. (2001). The splice of life: Alternative splicing and neurological disease. Nature Reviews. Neuroscience, 2(1), 43-50. DOI Scopus137 WoS123 Europe PMC110
2000	Jensen, K. B., Dredge, B. K., Stefani, G., Zhong, R., Buckanovich, R. J., Okano, H. J., . . . Darnell, R. B. (2000). Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron, 25(2), 359-371. DOI Scopus343 WoS315 Europe PMC305
1997	Stroeher, U. H., Parasivam, G., Kate Dredge, B., & Manning, P. A. (1997). Novel vibrio cholerae O139 genes involved in lipopolysaccharide biosynthesis. Journal of Bacteriology, 179(8), 2740-2747. DOI Scopus62 Europe PMC48
1995	Stroeher, U., Dredge, B., Morona, R., Brown, M., Karageorgos, L., Albert, M., & Manning, P. (1995). Genetic rearrangements in the rfb regions of Vibrio cholerae O1 and O139. Proceedings of the National Academy of Sciences of the United States of America, 92(22), 10374-10378. DOI Scopus88 WoS80 Europe PMC64

Conference Papers

Year	Citation
2005	Dredge, B., Webb, J., & Jensen, K. (2005). The role of the neuronal Hu RNA-binding proteins in the developing nervous system.. In 4th European Zebrafish Genetics and Development Meeting. Dresden, Germany.

Preprint

Year	Citation
2024	Pitino, E., Pascual-Reguant, A., Segato-Dezem, F., Wise, K., Salvador-Martinez, I., Crowell, H. L., . . . Martelotto, L. (2024). STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging. DOI
2022	Neumann, D., Pillman, K., Dredge, K., Bert, A., Bracken, C., Hollier, B., . . . Gregory, P. (2022). The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking. DOI

Date	Project/ No.	Investigators	Funding Body	Amount
2012-2015	1033391	Kirk Jensen, B. Kate Dredge, David Adelson.	NHMRC	$588,423
2009-2011	565424	Kirk Jensen, B. Kate Dredge.	NHMRC	$545,217
2005-2007	DP0559550	Kirk Jensen, B. Kate Dredge.	ARC	$320,608

Past Higher Degree by Research Supervision (University of Adelaide)

Date	Role	Research Topic	Program	Degree Type	Student Load	Student Name
2007 - 2011	Co-Supervisor	Investigating Mechanisms of Post-transcriptional Gene Regulation in the Germ Cells of Zebrafish	Doctor of Philosophy	Doctorate	Full Time	Miss Sophie Wiszniak

Position: Research Fellow
Phone: 83133351
Email: kate.dredge@adelaide.edu.au
Campus: North Terrace
Building: AHMS, floor 6
Org Unit: South Australian Immunogenomics Cancer Institute

Dr Kate Dredge

Appointments

Education

Journals

Conference Papers

Preprint

Past Higher Degree by Research Supervision (University of Adelaide)

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