Affiliate Senior Lecturer
Adelaide Medical School
Faculty of Health and Medical Sciences
Eligible to supervise Masters and PhD (as Co-Supervisor) - email supervisor to discuss availability.
I have had more than decade of clinical experience as a Registered Nurse, Midwife and Neonatal Nurse and played a pivotal role in the introduction of home gavage feeding to promote early discharge for preterm babies. I transitioned to clinical trial coordination and was instrumental in the design of web-based trial management systems enabling the quality completion of several large-scale, NHMRC and Industry funded RCTs at a standard recognised by top-ranking general medical journals including JAMA and the BMJ. These systems enabled the successful completion of my PhD project with a 90% follow up rate more than 6 years after the intervention. My work is the largest RCT to assess the long term
effects prenatal n-3 LCPUFA supplementation on symptoms of allergic disease at 6 years of age.
Contribution to the Field of Research
My research output has been facilitated by my nursing background and my experience as a clinical trials coordinator in the CRO area. I have a unique mix of high level clinical and research management skills. These helped me gain an APA and subsequent competitive Paediatric/Child Health Nursing Scholarship to conduct my PhD that resulted my being awarded a special commendation by the Dean of Graduate Studies for thesis excellence. In my PhD I assessed asthma and allergy outcomes of 603 six-year old children (90% of eligible) who were randomly exposed to omega-3 long chain fatty acids or a vegetable oil control in utero. This blinded follow-up took 2.5 years to complete resulting in 4 peer reviewed manuscripts (2 as first author), a book chapter with a further 2 first author manuscripts currently under review. My two major PhD papers were published in top ranking paediatric and nutrition journals (Pediatrics and AJCN) both with supportive editorials and was widely distributed online via Reuter Health. The international attention received by my work including an invitation to attend a workshop in Denmark and collaboration on future projects, is evidence of its impact. Expert groups making practice guideline recommendations, including the Australasian Society for Clinical Immunology and Allergy and the American Academy of Pediatrics have considered my findings. I have delivered 4 national and 3 international conference presentations, 2 of these as an invited speaker. I was successful in securing a place in the competitive ‘Fresh Science’ media training and went on to be named winner of the South Australian Event. I have been named CI on 3 grants totalling more than $2.7m and a pending 2018 NHMRC project grant. I am an enthusiastic advocate for clinical trials and was recently selected by the NHMRC to feature on the new Australian Clinical Trial website, sharing my views of being a researcher’.
Community engagement and participation
I designed and manage a Facebook page for SAHMRI Healthy Mothers, Babies and Children theme and have arranged several local events to inform the public about the latest research including a sold out 'Dinner with a Scientist' evening for Australian Society for Medical Research.
Date Position Institution name 2016 Afiliate Senior Lecturer University of Adelaide 2016 Post-doctoral Research Fellow South Australian Health & Medical Research Institute 2015 Research Fellow South Australian Health and Medical Research Institute, Adelaide 2009 - 2012 Clinical Trial Project Manager Baker IDI Heart and Diabetes Institute, Melbourne 2005 - 2009 Clinical Trial Manager Women's & Children's Health Research Institute, North Adelaide 1990 - 1991 Registerd Midwife The Queen Victoria Hospital 1984 - 1987 Registered Nurse The Queen Elizabeth Hospital
Awards and Achievements
Date Type Title Institution Name Country Amount 2016 Achievement Winner South Australian 'Fresh Science' Competition Science In Public, Victoria. Australia — 2016 Award Travel Grant Healthy Development Adelaide Australia $1000 2016 Scholarship Research and Ethics Training Scholarship Praxis Australia — $1000.00 2015 Recognition Deans Commendation Doctoral thesis Excellence University of Adelaide Australia — 2013 Scholarship MS McLeod Peadiatric/Child Health Nursing Scholarship MS McLeod Foundation Australia —
Date Institution name Country Title 2012 - 2015 University of Adelaide Australia PhD Medicine 2005 - 2007 University of Canberra Australia Advance Certificate Clinical Trial Management 1991 - 1992 The Queen Victoria Hospital Australia Graduate Midwife Program 1990 - 1991 The Queen Victoria Hospital Australia Registered Midwifery Certificate — Queen Elizabeth Hospital, Adelaide Australia Registered Nursing Certificate
Date Title Institution Country 2012 - 2015 PhD Medicine University of Adelaide, Adelaide Australia 2005 - 2007 Graduate Certificate Clinical Trial Management University of Canberra Australia
Date Title Institution name Country 0 Registered Midwifery Certificate Queen Victoria Hospital Australia 0 Registered Nursing Certificate The Queen Elizabeth Hospital —
Research InterestsAllergy Clinical and Sports Nutrition Clinical Trials Foetal Development and Medicine Food Nutritional Balance Health Policy Maternal Health Medical Ethics Midwifery Nutrition and Dietetics Paediatrics Paediatrics and Reproductive Medicine Pediatrics Public Health Public Health and Health Services Public Nutrition Intervention Quality Assurance Quality Management Research, Science and Technology Policy
Year Citation 2019 Gunaratne, A. W., Makrides, M., Collins, C. T., Gibson, R. A., McPhee, A. J., Sullivan, T. R., . . . Best, K. P. (2019). Docosahexaenoic acid supplementation of preterm infants and parent-reported symptoms of allergic disease at 7 years corrected age: follow-up of a randomized controlled trial.. The American journal of clinical nutrition, 109(6), 1600-1610.
2018 Best, K., Sullivan, T., Palmer, D., Gold, M., Martin, J., Kennedy, D., & Makrides, M. (2018). Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood - a longitudinal analysis of long-term follow-up of a randomized controlled trial. World Allergy Organization Journal, 11(1), 10-1-10-11.
DOI Scopus3 WoS1 Europe PMC1
2017 Best, K., & Makrides, M. (2017). Possible protective effect of prenatal omega-3 long-chain polyunsaturated fatty acids supplementation on persistent wheeze and asthma in early childhood. Evidence-Based Medicine, 22(3), 104.
DOI Scopus1 Europe PMC1
2017 Zhou, S., Best, K., Gibson, R., McPhee, A., Yelland, L., Quinlivan, J., & Makrides, M. (2017). Study protocol for a randomised controlled trial evaluating the effect of prenatal omega-3 LCPUFA supplementation to reduce the incidence of preterm birth: the ORIP trial. BMJ Open, 7(9), e018360-1-e018360-9.
DOI Scopus5 WoS4
2017 Gould, J., Best, K., & Makrides, M. (2017). Perinatal nutrition interventions and post-partum depressive symptoms. Journal of Affective Disorders, 224, 2-9.
DOI Scopus4 WoS3 Europe PMC1
2016 Makrides, M., & Best, K. (2016). Docosahexaenoic acid and preterm birth. Annals of Nutrition and Metabolism, 69(Suppl. 1), 30-34.
DOI Scopus4 WoS1 Europe PMC1
2016 Best, K., Gold, M., Kennedy, D., Martin, J., & Makrides, M. (2016). Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials. American Journal of Clinical Nutrition, 103(1), 128-143.
DOI Scopus39 WoS32 Europe PMC27
2016 Best, K., Sullivan, T., Palmer, D., Gold, M., Kennedy, D., Martin, J., & Makrides, M. (2016). Prenatal fish oil supplementation and allergy: 6-year follow-up of a randomized controlled trial. Pediatrics, 137(6), 1-9.
DOI Scopus17 WoS15 Europe PMC8
2010 Makrides, M., Gibson, R., McPhee, A., Yelland, L., Quinlivan, J., Ryan, P., . . . Griffith, E. (2010). Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: A randomized controlled trial. Jama-journal of the American Medical Association, 304(15), 1675-1683.
DOI Scopus302 WoS274 Europe PMC190
Year Citation 2018 Muhlhausler, B., Collins, C. T., Gould, J., Best, K. P., & Leghi, G. (2018). Polyunsaturated fatty acids: metabolism and nutritional requirements in pregnancy and infancy. In G. Burdge (Ed.), Polyunsaturated Fatty acid Metabolism (pp. 111-135). United Kingdom: Elsevier.
Year Citation 2015 Best, K. P., Sullivan, T., Gold, M., Kennedy, D., Martin, J., Palmer, D., & Makrides, M. (2015). Journal of Peadiatrics and Child Health. Poster session presented at the meeting of PSANZ. Melbourne. 2014 Best, K., Makrides, M., & Gold, M. (2014). Effect of maternal dietary long chain polyunsaturated fatty acid intake during pregnancy on clinical outcomes of allergic disease in the offspring: a systematic review. Poster session presented at the meeting of Abstracts of Australasian Society of Clinical Immunology and Allergy (ASCIA) 25th Annual Conference, as published in Internal Medicine Journal. Melbourne, Victoria: Wiley.
|Date||Project||Other Investigators||Funding Body||Amount|
|07/2017||MJN6640||Professor Maria Makrides, Dr Carmel Collins, Professor Robert Gibson, A/Professor Geraint Rogers, Dr Andrew McPhee, Dr Lisa Yelland||
Mead Johnson Nutritionals
|02/2017||Omega-3 in breastmilk||
A/Professor Beverly Muhlhausler, Professor Maria Makrides, Dr Carmel Collins, A/Professor Geraint Rogers,
|BASF Newtrition Grant
|10/2017||Phthalates and preterm birth||A/Professor Philippa Middleton, Professor Maria Makrides, A/Professor Jo Zhou, Professor Robert Gibson, Dr Andrew McPhee, Dr Lisa Yelland||Women's & Children's Hospital Foundation
Domestic, not for profit
Current Higher Degree by Research Supervision (University of Adelaide)
Date Role Research Topic Program Degree Type Student Load Student Name 2019 Co-Supervisor Folate and metabolized folic acid in pregnant women and their association with allergic diseases and DNA methylation Doctor of Philosophy Doctorate Full Time Ms Dian Caturini Sulistyoningrum 2016 Co-Supervisor Early life factors influencing the infant gut microbiota development Doctor of Philosophy Doctorate Full Time Miss Chloe Alexandra Douglas
Date Role Committee Institution Country 2017 - ongoing Member DOHaD Council Developmental Origins of Health and Disease Society Australia 2017 - ongoing Member IMPACT Committee Interdisciplinary Maternal Perinatal Australasian Collaborative Trials Network Australia 2016 - ongoing Member Low-risk Human Research Ethics Committee University of Adelaide Australia
Connect With Me