Karagh Loring

Karagh Loring

Higher Degree by Research Candidate

Adelaide Medical School

Faculty of Health and Medical Sciences

Intellectual disability (ID) affects 1 in 50 people worldwide, with genetic causes responsible for ~40% of these case. Up to 30% of children with ID also present with seizures, most unresponsive to anti-convulsant therapy, thus the need for treatment is high. Using mouse models with mutations in a known ID and seizure gene, ARX, we will investigate the effectiveness of short-term estradiol treatment on symptom alleviation. As part of this analysis I will monitor improvements to the onset and frequency of seizures, in conjunction with improvements in behavioural and cognitive deficits. My analysis will begin to elucidate the molecular and cellular changes following treatment that lead to phenotypic improvements. This knowledge may lead to future targets for therapeutic interventions for these patients.

  • Appointments

    Date Position Institution name
    2016 - 2016 NHMRC Graduate Research Assistant The University of Adelaide
  • Language Competencies

    Language Competency
    English Can read, write, speak, understand spoken and peer review
  • Education

    Date Institution name Country Title
    2015 - 2015 The University of Adelaide Australia Bachelor of Health Sciences (Honours)
    2011 - 2014 The University of Adelaide Australia Bachelor of Science (Biomedical Science)
  • Postgraduate Training

    Date Title Institution Country
    2017 PhD in Medicine The University of Adelaide Australia
  • Journals

    Year Citation
    2019 Jackson, M., Loring, K., Homan, C., Thai, M., Määttänen, L., Arvio, M., . . . Shoubridge, C. (2019). Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females. Life Science Alliance, 2(4), 18 pages.
  • Committee Memberships

    Date Role Committee Institution Country
    2017 - ongoing Secretary Health Sciences Postgraduate Association The University of Adelaide Australia
  • Phone: 83136145
  • Email: karagh.loring@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 8
  • Room: WS8062.47
  • Org Unit: Health and Medical Sciences Faculty Office

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