Jus St John

Professor Jus St John

NHMRC Grant-Funded Researchr E

School of Biomedicine

Faculty of Health and Medical Sciences

My group's research focuses on how the nuclear and mitochondrial genomes interact during development in order that the cells, tissues and organs of the resultant offspring function efficiently. To do this, we employ a number of assisted reproductive technologies that alter the interactions between the two genomes throughout development; and are either used clinically or are at various stages of development or validation. We are applying the knowledge we accumulate from this work to develop reproductive strategies for women that suffer from repeated failed fertilisation outcome or embryo developmental arrest; and for those who are carriers of severe mitochondrial disorders that are at risk of having affected children.

  • Journals
    Year Citation
    2025 St. John, J. C., Andreas, E., & Penn, A. (2025). Can the Supplementation of Oocytes with Extra Copies of mtDNA Impact Development Without Being Transmitted? A Molecular Account. International Journal of Molecular Sciences, 26(6), 25 pages.
    DOI
    2024 Penn, A., Andreas, E., Okada, T., & St John, J. C. (2024). Nuclear transfer leads to aberrant cell cycle regulation and translation, as determined by gene expression, and selection of mitochondrial DNA in porcine blastocysts. NAR Molecular Medicine, 1(4), ugae018-1-ugae018-22.
    DOI
    2024 Andreas, E., Penn, A., Okada, T., & St. John, J. C. (2024). Supplementation of Oocytes by Microinjection with Extra Copies of mtDNA Alters Metabolite Profiles and Interactions with Expressed Genes in a Tissue-Specific Manner. Biomolecules, 14(11), 1477-1-1477-20.
    DOI Scopus1 Europe PMC1
    2023 McIlfatrick, S., O'Leary, S., Okada, T., Penn, A., Nguyen, V. H. T., McKenny, L., . . . St. John, J. C. (2023). Does supplementation of oocytes with additional mtDNA influence developmental outcome?. iScience, 26(2), 105956-1-105956-27.
    DOI Scopus3 WoS1 Europe PMC3
    2023 Okada, T., McIlfatrick, S., & St. John, J. C. (2023). Mitochondrial DNA Deficiency and Supplementation in Sus scrofa Oocytes Influence Transcriptome Profiles in Oocytes and Blastocysts. International Journal of Molecular Sciences, 24(4), 1-26.
    DOI Scopus3 WoS2 Europe PMC2
    2023 Okada, T., Penn, A., & St. John, J. C. (2023). Mitochondrial DNA Supplementation of Oocytes Has Downstream Effects on the Transcriptional Profiles of Sus scrofa Adult Tissues with High mtDNA Copy Number. International Journal of Molecular Sciences, 24(8), 7545.
    DOI Scopus4 Europe PMC4
    2022 Okada, T., Sun, X., McIlfatrick, S., & St. John, J. C. (2022). Low guanine content and biased nucleotide distribution in vertebrate mtDNA can cause overestimation of non-CpG methylation. NAR Genomics and Bioinformatics, 4(1), 1-17.
    DOI Scopus1 Europe PMC1
    2022 Azumah, R., Hummitzsch, K., Hartanti, M. D., St John, J. C., Anderson, R. A., & Rodgers, R. J. (2022). Analysis of upstream regulators, networks, and pathways associated with the expression patterns of Polycystic Ovary Syndrome candidate genes during fetal ovary development. Frontiers in Genetics, 12, 762177-1-762177-16.
    DOI Scopus8 WoS5 Europe PMC7
    2022 Okada, T., McIlfatrick, S., Hin, N., Aryamanesh, N., Breen, J., & St John, J. C. (2022). Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts. Epigenetics and Chromatin, 15(1), 20 pages.
    DOI Scopus10 WoS7 Europe PMC7
    2022 Towarnicki, S. G., Youngson, N. A., Corley, S. M., St John, J. C., Melvin, R. G., Turner, N., . . . Ballard, J. W. O. (2022). Ancestral dietary change alters the development of Drosophila larvae through MAPK signalling. Fly, 16(1), 299-311.
    DOI Scopus4 WoS1 Europe PMC4
    2022 St John, J. C., Okada, T., Andreas, E., & Penn, A. (2022). The role of mtDNA in oocyte quality and embryo development. Molecular Reproduction and Development, 90(7), 621-633.
    DOI Scopus13 WoS4 Europe PMC9
    2021 St. John, J. C. (2021). Epigenetic Regulation of the Nuclear and Mitochondrial Genomes: Involvement in Metabolism, Development, and Disease. Annual Review of Animal Biosciences, 9(1), 203-224.
    DOI Scopus4 WoS1 Europe PMC4
    2020 Kapetanovic, R., Afroz, S. F., Ramnath, D., Lawrence, G. M. E. P., Okada, T., Curson, J. E. B., . . . Sweet, M. J. (2020). Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology and Cell Biology, 98(7), 528-539.
    DOI Scopus57 WoS38 Europe PMC42
    2020 Towarnicki, S. G., Youngson, N. A., Corley, S. M., St John, J. C., Turner, N., Morris, M. J., & Ballard, J. W. O. (2020). Ancestral dietary change alters development of<i>Drosophila</i>larvae through MAPK signalling.
    DOI
    2019 St John, J., Makanji, Y., Johnson, J., Tsai, T. -S., Lagondar, S., Rodda, F., . . . Temple-Smith, P. (2019). The transgenerational effects of oocyte mitochondrial supplementation. Scientific Reports, 9(1), 6694-1-6694-12.
    DOI Scopus15 WoS12 Europe PMC12
    2019 St John, J. C. (2019). Genomic balance: two genomes establishing synchrony to modulate cellular fate and function. Cells, 8(11), 1-14.
    DOI Scopus10 WoS9 Europe PMC10
    2019 St John, J. C. (2019). Mitochondria and female germline stem cells−a mitochondrial DNA perspective. Cells, 8(8), 852-1-852-15.
    DOI Scopus13 WoS9 Europe PMC14
    2019 Poulton, J., Steffann, J., Burgstaller, J., McFarland, R., Arbeithuber, B., Bengoa, J., . . . Wells, D. (2019). 243rd ENMC international workshop: Developing guidelines for management of reproductive options for families with maternally inherited mtDNA disease, Amsterdam, the Netherlands, 22-24 March 2019. NEUROMUSCULAR DISORDERS, 29(9), 725-733.
    DOI WoS9 Europe PMC11
    2018 Sun, X., Vaghjiani, V., Jayasekara, W. S. N., Cain, J. E., & St John, J. C. (2018). The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.. Clinical epigenetics, 10(1), 157.
    DOI Scopus36 WoS26 Europe PMC25
    2018 Sun, X., & St John, J. C. (2018). Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours. Epigenetics and Chromatin, 11(1), 53-1-53-18.
    DOI Scopus30 WoS23 Europe PMC26
    2018 St John, J. C., & Tsai, T. -S. (2018). The association of mitochondrial DNA haplotypes and phenotypic traits in pigs.. BMC genetics, 19(41), 1-12.
    DOI Scopus18 WoS14 Europe PMC11
    2018 Tsai, T. -S., & St John, J. C. (2018). The effects of mitochondrial DNA supplementation at the time of fertilization on the gene expression profiles of porcine preimplantation embryos.. Molecular reproduction and development, 85(6), 490-504.
    DOI Scopus17 WoS15 Europe PMC10
    2018 Sun, X., Johnson, J., & St John, J. (2018). Global DNA methylation synergistically regulates the nuclear and mitochondrial genomes in glioblastoma cells. Nucleic Acids Research, 46(12), 5977-5995.
    DOI Scopus44 WoS37 Europe PMC40
    2018 Tsai, T., Tyagi, S., & St John, J. (2018). The molecular characterisation of mitochondrial DNA deficient oocytes using a pig model. Human Reproduction, 33(5), 942-953.
    DOI Scopus22 WoS15 Europe PMC16
    2018 Srirattana, K., & St John, J. (2018). Additional mitochondrial DNA influences the interactions between the nuclear and mitochondrial genomes in a bovine embryo model of nuclear transfer. Scientific Reports, 8(1), 17 pages.
    DOI Scopus26 WoS18 Europe PMC19
    2018 St John, J. C., Srirattana, K., Tsai, T. S., & Sun, X. (2018). The mitochondrial genome: How it drives fertility. Reproduction, Fertility and Development, 30(1), 118-139.
    DOI Scopus7 WoS5 Europe PMC4
    2017 Lee, W. T., Sun, X., Tsai, T. S., Johnson, J. L., Gould, J. A., Garama, D. J., . . . St John, J. C. (2017). Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns. Cell Death Discovery, 3(1), 1-11.
    DOI Scopus37 WoS29 Europe PMC26
    2017 Srirattana, K., & St John, J. C. (2017). Manipulating the mitochondrial genome to enhance cattle embryo development. G3 : Genes, Genomes, Genetics, 7(7), 2065-2080.
    DOI Scopus24 WoS17 Europe PMC17
    2017 Vaghjiani, V., Cain, J. E., Lee, W., Vaithilingam, V., Tuch, B. E., & St John, J. C. (2017). Modulation of Mitochondrial DNA Copy Number to Induce Hepatocytic Differentiation of Human Amniotic Epithelial Cells. Stem Cells and Development, 26(20), 1505-1519.
    DOI Scopus2 WoS2 Europe PMC1
    2017 Tsai, T., Johnson, J., White, Y., & St John, J. (2017). The molecular characterization of porcine egg precursor cells. Oncotarget, 8(38), 63484-63505.
    DOI Scopus10 WoS10 Europe PMC11
    2017 Srirattana, K., McCosker, K., Schatz, T., & St John, J. C. (2017). Cattle phenotypes can disguise their maternal ancestry. BMC Genetics, 18(59), 11 pages.
    DOI Scopus22 WoS17 Europe PMC9
    2016 Sun, X., & John, J. C. S. (2016). The role of the mtDNA set point in differentiation, development and tumorigenesis. Biochemical Journal, 473(19), 2955-2971.
    DOI Scopus38 WoS30 Europe PMC25
    2016 Tsai, T., & St John, J. C. (2016). The role of mitochondrial DNA copy number, variants, and haplotypes in farm animal developmental outcome. Domestic Animal Endocrinology, 56, S133-S146.
    DOI Scopus16 WoS12 Europe PMC8
    2016 Lee, W. T. Y., & St. John, J. C. (2016). Mitochondrial DNA as an initiator of tumorigenesis. Cell Death and Disease, 7(3), 2 pages.
    DOI Scopus10 WoS8 Europe PMC7
    2016 Cagnone, G., Tsai, T. S., Srirattana, K., Rossello, F., Powell, D. R., Rohrer, G., . . . St John, J. C. (2016). Segregation of naturally occurring mitochondrial DNA variants in a mini-pig model. Genetics, 202(3), 931-944.
    DOI Scopus21 WoS20 Europe PMC17
    2016 Tsai, T., Rajasekar, S., & St John, J. (2016). The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus). BMC Genetics, 17(1), 67.
    DOI Scopus38 WoS32 Europe PMC20
    2016 St John, J. C., Tsai, T. S., & Cagnone, G. L. M. (2016). Mitochondrial DNA supplementation as an enhancer of female reproductive capacity. Current Opinion in Obstetrics and Gynecology, 28(3), 211-216.
    DOI Scopus5 WoS4 Europe PMC4
    2016 Cagnone, G. L. M., Tsai, T. S., Makanji, Y., Matthews, P., Gould, J., Bonkowski, M. S., . . . John, J. C. S. (2016). Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Scientific Reports, 6(1), 1-15.
    DOI Scopus73 WoS55 Europe PMC51
    2016 St John, J. C. (2016). Mitochondrial DNA copy number and replication in reprogramming and differentiation. Seminars in Cell and Developmental Biology, 52, 93-101.
    DOI Scopus48 WoS35 Europe PMC34
    2016 Johnson, J., Lee, W., Frazier, A. E., Vaghjiani, V., Laskowski, A., Rodriguez, A. L., . . . St John, J. C. (2016). Deletion of the Complex I Subunit NDUFS4 Adversely Modulates Cellular Differentiation. Stem Cells and Development, 25(3), 239-250.
    DOI Scopus8 WoS7 Europe PMC7
    2016 Lee, W. T. Y., Cain, J. E., Cuddihy, A., Johnson, J., Dickinson, A., Yeung, K. Y., . . . St John, J. C. (2016). Mitochondrial DNA plasticity is an essential inducer of tumorigenesis. Cell Death Discovery, 2(1), 11 pages.
    DOI Scopus30 WoS26 Europe PMC24
    2015 Lee, W., Johnson, J., Gough, D. J., Donoghue, J., Cagnone, G. L. M., Vaghjiani, V., . . . St John, J. C. (2015). Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny. Cell Death and Disease, 6(2), e1664.
    DOI Scopus89 WoS74 Europe PMC66
    2015 Lee, W. T. Y., & John, J. S. (2015). The control of mitochondrial DNA replication during development and tumorigenesis. Annals of the New York Academy of Sciences, 1350(1), 95-106.
    DOI Scopus41 WoS34 Europe PMC28
    2015 Henry, B. A., Loughnan, R., Hickford, J., Young, I. R., St John, J. C., & Clarke, I. (2015). Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep. Journal of Animal Science, 93(5), 2083-2093.
    DOI Scopus11 WoS10 Europe PMC7
    2015 Wu, L., Russell, D., Wong, S., Chen, M., Tsai, T., St John, J., . . . Robker, R. (2015). Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors. Development, 142(4), 681-691.
    DOI Scopus228 WoS184 Europe PMC154
    2015 St John, J. C. (2015). The mitochondrion, its genome and their contribution to well-being and disease. Molecular Human Reproduction, 21(1), 1-2.
    DOI Scopus6 WoS2 Europe PMC6
    2014 St John, J., Srirattana, K., & Clarke, I. (2014). Modifying the mitochondrial genome to enhance animal production. Australasian Biotechnology, 24(3), 61.
    2014 Yeung, K. Y., Dickinson, A., Donoghue, J. F., Polekhina, G., White, S. J., Grammatopoulos, D. K., . . . St John, J. C. (2014). The identification of mitochondrial DNA variants in glioblastoma multiforme. Acta Neuropathologica Communications, 2(1), 1.
    DOI Scopus50 WoS45 Europe PMC52
    2014 Sobinoff, A. P., Sutherland, J. M., Beckett, E. L., Stanger, S. J., Johnson, R., Jarnicki, A. G., . . . Mclaughlin, E. A. (2014). Damaging legacy: Maternal cigarette smoking has long-term consequences for male offspring fertility. Human Reproduction, 29(12), 2719-2735.
    DOI Scopus45 WoS41 Europe PMC31
    2014 St John, J. (2014). The control of mtDNA replication during differentiation and development. Biochimica et Biophysica Acta - General Subjects, 1840(4), 1345-1354.
    DOI Scopus92 WoS73 Europe PMC68
    2014 Nagley, P., St John, J., Gabriel, K., & McKenzie, M. (2014). Mitochondrial research in Australia: A major player in worldwide trends. Biochimica et Biophysica Acta - General Subjects, 1840(4), 1225-1226.
    DOI
    2014 Mckenzie, M., Chiotis, M., Hroudová, J., Lopez Sanchez, M., Lim, S., Cook, M., . . . Trounce, I. (2014). Capture of somatic mtDNA point mutations with severe effects on oxidative phosphorylation in synaptosome cybrid clones from human brain. Human Mutation, 35(12), 1476-1484.
    DOI Scopus12 WoS12 Europe PMC9
    2014 Lee, T., Clarke, I., St John, J., Young, I., Leury, B., Rao, A., . . . Henry, B. (2014). High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle. FASEB Journal, 28(1), 35-44.
    DOI Scopus16 WoS15 Europe PMC11
    2013 Dickinson, A., Yeung, K. Y., Donoghue, J., Baker, M. J., Kelly, R. D., McKenzie, M., . . . St John, J. C. (2013). The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death and Differentiation, 20(12), 1644-1653.
    DOI Scopus110 WoS97 Europe PMC97
    2013 Kelly, R. D. W., Rodda, A. E., Dickinson, A., Mahmud, A., Nefzger, C. M., Lee, W., . . . St John, J. C. (2013). Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. Stem Cells, 31(4), 703-716.
    DOI Scopus64 WoS63 Europe PMC50
    2013 Kelly, R. D. W., Sumer, H., McKenzie, M., Facucho-Oliveira, J., Trounce, I. A., Verma, P. J., & St John, J. C. (2013). The Effects of Nuclear Reprogramming on Mitochondrial DNA Replication. Stem Cell Reviews and Reports, 9(1), 1-15.
    DOI Scopus46 WoS39 Europe PMC36
    2013 John, J. S. (2013). A tribute to somatic cell reprogrammers. Molecular Human Reproduction, 19(2), 55-56.
    DOI
    2012 Kelly, R. D. W., Mahmud, A., McKenzie, M., Trounce, I. A., & St John, J. C. (2012). Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Research, 40(20), 10124-10138.
    DOI Scopus154 WoS129 Europe PMC121
    2012 St John, J. C. (2012). Transmission, inheritance and replication of mitochondrial DNA in mammals: Implications for reproductive processes and infertility. Cell and Tissue Research, 349(3), 795-808.
    DOI Scopus26 WoS22 Europe PMC12
    2011 Rae, P. C., Kelly, R. D., Egginton, S., & St John, J. C. (2011). Angiogenic potential of endothelial progenitor cells and embryonic stem cells. Vascular Cell, 3(1), 15 pages.
    DOI Scopus33 WoS30 Europe PMC21
    2011 Sanchez-Partida, L., Kelly, R., Sumer, H., Lo, C., Aharon, R., Holland, M., . . . John St, J. (2011). The generation of live offspring from vitrified oocytes. PLoS ONE, 6(6), e21597.
    DOI Scopus19 WoS14 Europe PMC13
    2011 Jiang, Y., Kelly, R., Peters, A., Fulka, H., Dickinson, A., Mitchell, D. A., & St. John, J. C. (2011). Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors. PLoS ONE, 6(4), 12 pages.
    DOI Scopus46 WoS27 Europe PMC26
    2011 Kelly, R. D. W., & St. John, J. C. (2011). Role of mitochondrial DNA replication during differentiation of reprogrammed stem cells. International Journal of Developmental Biology, 54(11-12), 1659-1670.
    DOI Scopus16 WoS11 Europe PMC12
    2010 St John, J. C., & Campbell, K. H. S. (2010). The battle to prevent the transmission of mitochondrial DNA disease: Is karyoplast transfer the answer. Gene Therapy, 17(2), 147-149.
    DOI Scopus16 WoS15 Europe PMC8
    2010 St. John, J. C., Facucho-Oliveira, J., Jiang, Y., Kelly, R., & Salah, R. (2010). Mitochondrial DNA transmission, replication and inheritance: A journey from the gamete through the embryo and into offspring and embryonic stem cells. Human Reproduction Update, 16(5), 488-509.
    DOI Scopus234 WoS191 Europe PMC169
    2010 Lee, J. H., Peters, A., Fisher, P., Bowles, E. J., St. John, J. C., & Campbell, K. H. S. (2010). Generation of mtDNA homoplasmic cloned lambs. Cellular Reprogramming, 12(3), 347-355.
    DOI Scopus28 WoS21 Europe PMC16
    2009 Fulka, J., Loi, P., Ptak, G., Fulka, H., & John, J. S. (2009). Hope for the mammoth?. Cloning and Stem Cells, 11(1), 1-3.
    DOI Scopus7 WoS7 Europe PMC7
    2009 Facucho-Oliveira, J. M., & John St., J. C. (2009). The relationship between pluripotency and mitochondrial DNA proliferation during early embryo development and embryonic Stem Cell differentiation. Stem Cell Reviews and Reports, 5(2), 140-158.
    DOI Scopus210 WoS179 Europe PMC165
    2009 Taylor, R. A., Wang, H., Wilkinson, S. E., Richards, M. G., Britt, K. L., Vaillant, F., . . . Risbridger, G. P. (2009). Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers. Stem Cells, 27(12), 3032-3042.
    DOI Scopus26 WoS26 Europe PMC21
    2008 Fulka, J., Fulka, H., St John, J., Galli, C., Lazzari, G., Lagutina, I., . . . Loi, P. (2008). Cybrid human embryos - warranting opportunities to augment embryonic stem cell research. Trends in Biotechnology, 26(9), 469-474.
    DOI Scopus6 WoS5 Europe PMC3
    2008 Bowles, E. J., Tecirlioglu, R. T., French, A. J., Holland, M. K., & St. John, J. C. (2008). Mitochondrial DNA transmission and transcription after somatic cell fusion to one or more cytoplasts. Stem Cells, 26(3), 775-782.
    DOI Scopus41 WoS34 Europe PMC26
    2008 St John, J. C., Armstrong, L., Minger, S. L., & Campbell, K. H. S. (2008). Law should recognize value of interspecies embryos [1]. Nature, 451(7179), 627.
    DOI Scopus5 WoS6 Europe PMC3
    2007 St John, J., & Lovell-Badge, R. (2007). Human-animal cytoplasmic hybrid embryos, mitochondria, and an energetic debate. Nature Cell Biology, 9(9), 988-992.
    DOI Scopus26 WoS19 Europe PMC15
    2007 Bowles, E. J., Lee, J. H., Alberio, R., Lloyd, R. E. I., Stekel, D., Campbell, K. H. S., & St. John, J. C. (2007). Contrasting effects of in vitro fertilization and nuclear transfer on the expression of mtDNA replication factors. Genetics, 176(3), 1511-1526.
    DOI Scopus51 WoS48 Europe PMC39
    2007 St John, J. C., Bowles, E. J., & Amaral, A. (2007). Sperm mitochondria and fertilisation.. Society of Reproduction and Fertility supplement, 65, 399-416.
    Scopus23 Europe PMC12
    2007 Spikings, E. C., Alderson, J., & St. John, J. C. (2007). Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development. Biology of Reproduction, 76(2), 327-335.
    DOI Scopus223 WoS194 Europe PMC164
    2007 Amaral, A., Ramalho-Santos, J., & St John, J. C. (2007). The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm. Human Reproduction, 22(6), 1585-1596.
    DOI Scopus121 WoS100 Europe PMC81
    2007 Facucho-Oliveira, J. M., Alderson, J., Spikings, E. C., Egginton, S., & St. John, J. C. (2007). Mitochondrial DNA replication during differentiation of murine embryonic stem cells. Journal of Cell Science, 120(22), 4025-4034.
    DOI Scopus242 WoS228 Europe PMC210
    2007 Fulka, J., Fulka, H., & St. John, J. C. (2007). Transmission of mitochondrial DNA disorders: Possibilities for the elimination of mutated mitochondria. Cloning and Stem Cells, 9(1), 47-50.
    DOI Scopus8 WoS6 Europe PMC6
    2006 Spikings, E. C., Alderson, J., & St. John, J. C. (2006). Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer. Human Reproduction Update, 12(4), 401-415.
    DOI Scopus66 WoS60 Europe PMC42
    2006 Poulton, J., Kennedy, S., Oakeshott, P., & St John, J. (2006). Nuclear transfer to prevent mitochondrial DNA diseases. Lancet, 368(9538), 841.
    DOI Scopus9 WoS7 Europe PMC5
    2006 Santos, T. A., El Shourbagy, S., & St. John, J. C. (2006). Mitochondrial content reflects oocyte variability and fertilization outcome. Fertility and Sterility, 85(3), 584-591.
    DOI Scopus341 WoS292 Europe PMC243
    2006 Lloyd, R. E., Lee, J. H., Alberio, R., Bowles, E. J., Ramalho-Santos, J., Campbell, K. H. S., & St. John, J. C. (2006). Aberrant nucleo-cytoplasmic cross-talk results in donor cell mtDNA persistence in cloned embryos. Genetics, 172(4), 2515-2527.
    DOI Scopus59 WoS54 Europe PMC41
    2006 St John, J. C., Amaral, A., Bowles, E., Oliveira, J. F., Lloyd, R., Freitas, M., . . . Ramalho-Santos, J. (2006). The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells.. Methods in molecular biology (Clifton, N.J.), 331, 347-374.
    DOI Scopus47 Europe PMC44
    2006 El Shourbagy, S. H., Spikings, E. C., Freitas, M., & St. John, J. C. (2006). Mitochondria directly influence fertilisation outcome in the pig. Reproduction, 131(2), 233-245.
    DOI Scopus277 WoS246 Europe PMC202
    2005 Fleming, C., Maldjian, A., Da Costa, D., Rullay, A. K., Haddleton, D. M., St John, J., . . . Davis, B. G. (2005). A Carbohydrate-Antioxidant Hybrid Polymer Reduces Oxidative Damage in Spermatozoa and Enhances Fertility. Nature Chemical Biology, 1(5), 270-274.
    DOI Scopus65 WoS59 Europe PMC24
    2005 St. John, J. C., Moffatt, O., & D'Souza, N. (2005). Aberrant heteroplasmic transmission of mtDNA in cloned pigs arising from double nuclear transfer. Molecular Reproduction and Development, 72(4), 450-460.
    DOI Scopus36 WoS30 Europe PMC25
    2005 St John, J. C., & Alderson, J. (2005). Stem-cell banking: The size of the task. Lancet, 366(9502), 1991-1992.
    DOI Scopus3 WoS1 Europe PMC2
    2005 St. John, J. C., Ramalho-Santos, J., Gray, H. L., Petrosko, P., Rawe, V. Y., Navara, C. S., . . . Schatten, G. P. (2005). The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stemn cells. Cloning and Stem Cells, 7(3), 141-153.
    DOI Scopus212 WoS185 Europe PMC167
    2005 St. John, J. C., Jokhi, R. P., & Barratt, C. L. R. (2005). The impact of mitochondrial genetics on male infertility. International Journal of Andrology, 28(2), 65-73.
    DOI Scopus98 WoS74 Europe PMC67
    2004 St. John, J. C., & Schatten, G. (2004). Paternal mitochondrial DNA transmission during nonhuman primate nuclear transfer. Genetics, 167(2), 897-905.
    DOI Scopus66 WoS51 Europe PMC35
    2004 St. John, J. C., Lloyd, R. E. I., Bowles, E. J., Thomas, E. C., & El Shourbagy, S. (2004). The consequences of nuclear transfer for mammalian foetal development and offspring survival. A mitochondrial DNA perspective. Reproduction, 127(6), 631-641.
    DOI Scopus74 WoS59 Europe PMC50
    2004 Mital, D., White, D. J., & St John, J. C. (2004). Mitochondrial DNA and sperm quality in patients on antiretroviral therapy - Response [3]. AIDS, 18(6), 963.
    DOI Scopus4 WoS4 Europe PMC4
    2004 Barratt, C. L. R., St. John, J. C., & Afnan, M. (2004). Clinical challenges in providing embryos for stem-cell initiatives. Lancet, 364(9429), 115-118.
    DOI Scopus21 WoS17 Europe PMC14
    2004 St John, J. C., Lloyd, R., & El Shourbagy, S. (2004). The potential risks of abnormal transmission of mtDNA through assisted reproductive technologies. Reproductive BioMedicine Online, 8(1), 34-44.
    DOI Scopus31 WoS23 Europe PMC13
    2003 Payne, C., St. John, J. C., Ramalho-Santos, J., & Schatten, G. (2003). LIS1 Association with Dynactin is Required for Nuclear Motility and Genomic Union in the Fertilized Mammalian Oocyte. Cell Motility and the Cytoskeleton, 56(4), 245-251.
    DOI Scopus18 WoS16 Europe PMC16
    2002 Perkins, J., St. John, J., & Ahmed, A. (2002). Modulation of trophoblast cell death by oxygen and EGF. Molecular Medicine, 8(12), 847-856.
    DOI Scopus25 WoS24 Europe PMC23
    2002 St. John, J. C. (2002). Ooplasm donation in humans: The need to investigate the transmission of mitochondrial DNA following cytoplasmic transfer. Human Reproduction, 17(8), 1954-1958.
    DOI Scopus47 WoS42 Europe PMC29
    2001 White, D. J., Mital, D., Taylor, S., & John, J. C. S. (2001). Sperm mitochondrial DNA deletions as a consequence of long term highly active antiretroviral therapy. AIDS, 15(8), 1061-1062.
    DOI Scopus57 WoS39 Europe PMC31
    2001 St. John, J. C., Jokhi, R. P., & Barratt, C. L. R. (2001). Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology. Molecular Human Reproduction, 7(1), 103-111.
    DOI Scopus89 WoS74 Europe PMC57
    2000 John, J. C. S., & De Jonge, C. J. (2000). A hypothesis for transmission of paternal mitochondrial DNA. Reproductive Medicine Review, 8(1), 73-85.
    DOI Scopus6
    2000 St. John, J. C., Sakkas, D., & Barratt, C. L. R. (2000). A role for mitochondrial DNA and sperm survival. Journal of Andrology, 21(2), 189-199.
    Scopus59 WoS57 Europe PMC33
    2000 Ahmed, A., Rahman, M., Zhang, X., Acevedo, C. H., Nijjar, S., Rushton, I., . . . St. John, J. (2000). Induction of Placental Heme Oxygenase-1 Is Protective Against TNFα-induced Cytotoxicity and Promotes Vessel Relaxation. Molecular Medicine, 6(5), 391-409.
    DOI Scopus143 WoS132 Europe PMC109
    2000 St John, J., Sakkas, D., Dimitriadi, K., Barnes, A., Maclin, V., Ramey, J., . . . De Jonge, C. (2000). Failure of elimination of paternal mitochondrial DNA in abnormal embryos. Lancet, 355(9199), 200.
    DOI Scopus83 WoS71 Europe PMC49
    1999 St. John, J. C. (1999). Incorporating molecular screening techniques into the modern andrology laboratory. Journal of Andrology, 20(6), 692-701.
    Scopus9 WoS4 Europe PMC1
    1999 Sakkas, D., Mariethoz, E., & St. John, J. C. (1999). Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the fas-mediated pathway. Experimental Cell Research, 251(2), 350-355.
    DOI Scopus306 WoS251 Europe PMC174
    1997 St. John, J. C., Cooke, I. D., Barratt, C. L. R., & Johns, D. R. (1997). Mitochondrial mutations and male infertility [2]. Nature Medicine, 3(2), 124-125.
    DOI Scopus59 WoS68 Europe PMC30
    1997 St John, J. C., Barratt, C. L. R., Brenner, C. A., Scott, J., & Cohen, J. (1997). Use of anucleate donor oocyte cytoplasm in recipient eggs (multiple letters) [16]. Lancet, 350(9082), 961-962.
    DOI Scopus2 WoS12 Europe PMC10
    - St. John, J. C. (n.d.). Mitochondrial<scp>DNA</scp>: Fate of the Paternal Mitochondrial Genome.
    DOI

  • Books
    Year Citation
    2013 St. John, J. C. (2013). Mitochondrial DNA, mitochondria, disease and stem cells. J. C. St. John (Ed.), Humana Press.
    DOI
    2007 St John, J. C. (2007). Preface (Vol. 77). Elsevier.
    DOI
    2007 Bowles, E. J., Campbell, K. H. S., & St. John, J. C. (2007). Nuclear Transfer: Preservation of a Nuclear Genome at the Expense of Its Associated mtDNA Genome(s) (Vol. 77). J. C. StJohn (Ed.), ELSEVIER ACADEMIC PRESS INC.
    DOI Scopus46 WoS36 Europe PMC27

  • Book Chapters
    Year Citation
    2019 Srirattana, K., & St John, J. (2019). Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction. In P. Sutovsky (Ed.), Cellular and Molecular Basis of Mitochondrial Inheritance (Vol. 231, pp. 75-103). Switzerland: Springer Nature.
    DOI Scopus13 WoS11 Europe PMC8
    2016 Cagnone, G., Vaghjiani, V., Lee, W., Sun, C., Johnson, J., Yeung, K. Y., & St John, J. C. (2016). Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. In K. Turksen, & A. Nagy (Eds.), Induced Pluripotent Stem (iPS) Cells: Methods and Protocols (Vol. 1357, pp. 231-267). New York; USA: Springer.
    DOI Scopus2 Europe PMC2
    2016 Sun, X., Lee, W., Vaghjiani, V., & St John, J. C. (2016). Analysis of mitochondrial DNA copy number and its regulation through DNA methylation of POLGA. In M. McKenzie (Ed.), Mitochondrial DNA: Methods and Protocols (Vol. 1351, pp. 131-141). New York; USA: Springer.
    DOI Scopus5 Europe PMC4
    2015 Lee, W., Kelly, R. D. W., Yeung, K. Y., Cagnone, G., McKenzie, M., & St John, J. C. (2015). Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells. In P. J. Verma, & H. Sumer (Eds.), Cell Reprogramming: Methods and Protocols (Vol. 1330, pp. 219-252). New York; USA: Springer.
    DOI Scopus3 Europe PMC1
    2013 Yeung, K. Y., Dickinson, A., & St. John, J. C. (2013). The Role of Mitochondrial DNA in Tumorigenesis. In Mitochondrial DNA, Mitochondria, Disease and Stem Cells (pp. 119-155). Humana Press.
    DOI Scopus1
    2013 Facucho-Oliveira, J., Kulkarni, T., Machado-Oliveira, G., & St. John, J. C. (2013). From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases. In Mitochondrial DNA, Mitochondria, Disease and Stem Cells (pp. 87-118). Humana Press.
    DOI
    2013 St. John, J. C. (2013). Mitochondrial DNA: Its Transmission from Gametes and Embryos. In Principles of Cloning: Second Edition (pp. 429-439). Elsevier.
    DOI Scopus1
    2013 Kelly, R. D. W., Mahmud, A., & St. John, J. C. (2013). Assisted Reproductive Technologies: The Potential to Prevent the Transmission of Mutant mtDNA from One Generation to the Next. In Mitochondrial DNA, Mitochondria, Disease and Stem Cells (pp. 157-183). Humana Press.
    DOI
    2012 St. John, J. C., & Campbell, K. H. S. (2012). The consequences of reprogramming a somatic cell for mitochondrial DNA transmission, inheritance and replication. In Nuclear Reprogramming and Stem Cells (pp. 83-97). Humana Press.
    DOI

  • Conference Papers
    Year Citation
    2014 St John, J. C. (2014). SUPPLEMENTING OOCYTES WITH AUTOLOGOUS MITOCHONDRIA ENHANCES FERTILIZATION OUTCOMES.. In FERTILITY AND STERILITY Vol. 102 (pp. E330). Honolulu, HI: ELSEVIER SCIENCE INC.
    DOI
    2012 Lee, Y. S., MacIntyre, D. A., Pirianov, G., Herbert, B., Terzidou, V., Johnson, M. R., & Bennett, P. R. (2012). Inhibition of AP1 Delays LPS-Induced Preterm Labour and Improves Pup Outcome in the Murine Model. In REPRODUCTIVE SCIENCES Vol. 19 (pp. 120A). SAGE PUBLICATIONS INC.
    2009 St. John, J. C. (2009). mtDNA and sperm function. In Systems Biology in Reproductive Medicine Vol. 55 (pp. 17-18).
    2008 Fulka, H., St. John, J. C., Fulka, J., & Hozák, P. (2008). Chromatin in early mammalian embryos: Achieving the pluripotent state. In Differentiation Vol. 76 (pp. 3-14). England: ELSEVIER SCI LTD.
    DOI Scopus50 WoS43 Europe PMC29
    2004 Ramalho-Santos, J., Sammak, P., Chong, K. Y., Qidwai, H., Rawe, V. Y., St John, J. C., & Schatten, G. (2004). Membrane trafficking and organelle dynamics in undifferentiated embryonic stem cells: Endomembrane biogenesis and expansion coupled with differentiation.. In BIOLOGY OF REPRODUCTION (pp. 216-217). Univ British Columbia, Vancouver, CANADA: SOC STUDY REPRODUCTION.
    2002 St. John, J. C. (2002). The transmission of mitochondrial DNA following assisted reproductive techniques. In Theriogenology Vol. 57 (pp. 109-123). FOZ DO IGUACU, BRAZIL: ELSEVIER SCIENCE INC.
    DOI Scopus42 WoS39 Europe PMC29
    2000 O'Connell, M., St John, J. C., McClure, N., Steele, E. K., & Lewis, S. E. M. (2000). A comparison of mitochondrial DNA deletions in proximal epididymal and testicular spermatozoa in males with obstructive azoospermia. In HUMAN REPRODUCTION Vol. 15 (pp. 114-115). OXFORD UNIV PRESS.
    1999 Barratt, C. L. R., St John, J. C., & Afnan, M. (1999). Genetic testing of the male.. In C. Gagnon (Ed.), MALE GAMETE: FROM BASIC SCIENCE TO CLINICAL APPLICATIONS (pp. 397-405). MONTREAL, CANADA: CACHE RIVER PRESS.
    WoS1
    1998 Barratt, C. L. R., & St John, J. C. (1998). Diagnostic tools in male infertility. In Human Reproduction Vol. 13 (pp. 51-61). THESSALONIKI, GREECE: OXFORD UNIV PRESS.
    DOI Scopus13 WoS9 Europe PMC5
    1997 St John, J. C., Cooke, I. D., & Barratt, C. L. R. (1997). The Use of Long PCR to detect multiple deletions in the mitochondrial DNA of human testicular tissue from azoospermic and severe oligozoospermic patients. In C. Barratt, C. DeJonge, D. Mortimer, & J. Parinaud (Eds.), GENETICS OF HUMAN MALE FERTILITY (pp. 333-347). COLLIOURE, FRANCE: EDITIONS EDK.
    WoS6
    1997 StJohn, J. C., Jokhi, R. P., Barratt, C. L. R., & Cooke, I. D. (1997). The effects of mitochondrial dysfunction on sperm motility. In HUMAN REPRODUCTION Vol. 12 (pp. P11). OXFORD UNIV PRESS.

  • Conference Items
    Year Citation
    2014 Chang, J. R., Chang, C. W., Chao, S. J., Cheng, A., Dai, K., Lee, J. T., . . . Yang, C. P. (2014). Preface. Poster session presented at the meeting of Geotechnical Special Publication.

2021 – 2025    NHMRC Ideas Grant (GNT2000723), Understanding the benefits and limitations of metaphase II spindle transfer (St. John J) $1,629,373.

2019 – 2022: NHMRC Project Grant (GNT1160106), Understanding how mitochondrial DNA contributes to embryo development (St. John J) $669,790

2018 – 2020: NHMRC Development Grant (GNT1136065), Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity (St. John J, McKenzie W, Western P, Rombauts L) $670,867.20.

2017 – 2018: The Winston Foundation (WF1), Developing a canine in vitro maturation culture system (St. John J) $42,000

2016 – 2018: OvaScience Inc. Waltham, USA. Renewal Grant, Safety of Mitochondrial Transfer (St. John J) $600,000.

2016 – 2019: ARC Discovery Grant(DP160102575), Diet influences the selective advantage of mitochondrial DNA mutations (Ballard B, St. John J, Smyth G) $313,600.00

2015 – 2017: NHMRC Project Grant(GNT1079309) - Metabolic and molecular basis of embryo signalling (Lane M, St. John J, Zander-Fox D) $397,077.00

2014 – 2016: Australian Mitochondrial Disease Foundation- Preventing the transmission of mutant mitochondrial DNA (St. John J) $25,000

2013 – 2016: OvaScience Inc- Determining the safety of homologous mitochondrial transfer in a mini-pig model (St. John J) $1,250,000

2013 – 2015: NHMRC Project Grant(GNT1041471) - Understanding mitochondrial DNA segregation and transmission (CIA - St. John J; Trounce I) $492,863

2013 – 2015: Zwart Estate- The role of mtDNA variants in glioblastoma (St. John J) $133,131

2013 – 2016: Australian Pork Limited- Defining the role of mitochondrial DNA in pig fertility (St. John J) $92,637

2013 – 2014: Johnston Estate- The generation of stem cell models of mtDNA disease (St. John J) $170,000

2012 – 2014: NHMRC Project Grant(GNT1022222) - Understanding the pathogenesis of mitochondrial disease using iPS cells (Thorburn D, St. John J, Frazier A, Nisbet D, White S) $618,675

2011: Marian and EH Flack Trust- Funding to purchase a High Resolution Melting Curve Analysis Machine(White S, Western P, St. John J, Watkins DN) $30,000.

  • Committee Memberships
    Date Role Committee Institution Country
    2019 - 2020 Member Mitochondrial Donation Expert Working Committee National Health and Medical Research Council Australia
    2018 - 2021 Member Embryo Research Licencing Committee National Health and Medical Reseach Council Australia
  • Position: NHMRC Grant-Funded Researchr E
  • Email: jus.stjohn@adelaide.edu.au
  • Campus: North Terrace
  • Building: Adelaide Health and Medical Sciences, floor 5
  • Org Unit: Medical Sciences
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