Professor Jus St John
NHMRC Grant-Funded Researchr E
School of Biomedicine
Faculty of Health and Medical Sciences
My group's research focuses on how the nuclear and mitochondrial genomes interact during development in order that the cells, tissues and organs of the resultant offspring function efficiently. To do this, we employ a number of assisted reproductive technologies that alter the interactions between the two genomes throughout development; and are either used clinically or are at various stages of development or validation. We are applying the knowledge we accumulate from this work to develop reproductive strategies for women that suffer from repeated failed fertilisation outcome or embryo developmental arrest; and for those who are carriers of severe mitochondrial disorders that are at risk of having affected children.
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Appointments
Date Position Institution name 2019 - ongoing Professor University of Adelaide 2009 - 2019 Professor and Centre Head Hudson Institute of Medical Research 2007 - 2009 Professor of Reproductive Biology University of Warwick 2000 - 2007 Lecturer University of Birmingham -
Language Competencies
Language Competency German Can read, write, speak, understand spoken and peer review -
Education
Date Institution name Country Title 1999 University of Birmingham United Kingdom PhD 1995 University of Sheffield United Kingdom BSc (Hons) -
Research Interests
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Journals
Year Citation 2025 St. John, J. C., Andreas, E., & Penn, A. (2025). Can the Supplementation of Oocytes with Extra Copies of mtDNA Impact Development Without Being Transmitted? A Molecular Account. International Journal of Molecular Sciences, 26(6), 2746-1-2746-25.
2024 Penn, A., Andreas, E., Okada, T., & St John, J. C. (2024). Nuclear transfer leads to aberrant cell cycle regulation and translation, as determined by gene expression, and selection of mitochondrial DNA in porcine blastocysts. NAR Molecular Medicine, 1(4), ugae018-1-ugae018-22.
2024 Andreas, E., Penn, A., Okada, T., & St. John, J. C. (2024). Supplementation of Oocytes by Microinjection with Extra Copies of mtDNA Alters Metabolite Profiles and Interactions with Expressed Genes in a Tissue-Specific Manner. Biomolecules, 14(11), 1477-1-1477-20.
Scopus1 Europe PMC12023 McIlfatrick, S., O'Leary, S., Okada, T., Penn, A., Nguyen, V. H. T., McKenny, L., . . . St. John, J. C. (2023). Does supplementation of oocytes with additional mtDNA influence developmental outcome?. iScience, 26(2), 105956-1-105956-27.
Scopus3 WoS1 Europe PMC32023 Okada, T., McIlfatrick, S., & St. John, J. C. (2023). Mitochondrial DNA Deficiency and Supplementation in Sus scrofa Oocytes Influence Transcriptome Profiles in Oocytes and Blastocysts. International Journal of Molecular Sciences, 24(4), 1-26.
Scopus3 WoS2 Europe PMC22023 Okada, T., Penn, A., & St. John, J. C. (2023). Mitochondrial DNA Supplementation of Oocytes Has Downstream Effects on the Transcriptional Profiles of Sus scrofa Adult Tissues with High mtDNA Copy Number. International Journal of Molecular Sciences, 24(8), 7545.
Scopus4 Europe PMC42022 Okada, T., Sun, X., McIlfatrick, S., & St. John, J. C. (2022). Low guanine content and biased nucleotide distribution in vertebrate mtDNA can cause overestimation of non-CpG methylation. NAR Genomics and Bioinformatics, 4(1), 1-17.
Scopus1 Europe PMC12022 Azumah, R., Hummitzsch, K., Hartanti, M. D., St John, J. C., Anderson, R. A., & Rodgers, R. J. (2022). Analysis of upstream regulators, networks, and pathways associated with the expression patterns of Polycystic Ovary Syndrome candidate genes during fetal ovary development. Frontiers in Genetics, 12, 762177-1-762177-16.
Scopus8 WoS5 Europe PMC72022 Okada, T., McIlfatrick, S., Hin, N., Aryamanesh, N., Breen, J., & St John, J. C. (2022). Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts. Epigenetics and Chromatin, 15(1), 20 pages.
Scopus10 WoS7 Europe PMC72022 Towarnicki, S. G., Youngson, N. A., Corley, S. M., St John, J. C., Melvin, R. G., Turner, N., . . . Ballard, J. W. O. (2022). Ancestral dietary change alters the development of Drosophila larvae through MAPK signalling. Fly, 16(1), 299-311.
Scopus4 WoS1 Europe PMC42022 St John, J. C., Okada, T., Andreas, E., & Penn, A. (2022). The role of mtDNA in oocyte quality and embryo development. Molecular Reproduction and Development, 90(7), 621-633.
Scopus15 WoS4 Europe PMC112021 St. John, J. C. (2021). Epigenetic Regulation of the Nuclear and Mitochondrial Genomes: Involvement in Metabolism, Development, and Disease. Annual Review of Animal Biosciences, 9(1), 203-224.
Scopus5 WoS1 Europe PMC42020 Kapetanovic, R., Afroz, S. F., Ramnath, D., Lawrence, G. M. E. P., Okada, T., Curson, J. E. B., . . . Sweet, M. J. (2020). Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology and Cell Biology, 98(7), 528-539.
Scopus57 WoS38 Europe PMC472020 Towarnicki, S. G., Youngson, N. A., Corley, S. M., St John, J. C., Turner, N., Morris, M. J., & Ballard, J. W. O. (2020). Ancestral dietary change alters development of<i>Drosophila</i>larvae through MAPK signalling.
2019 St John, J., Makanji, Y., Johnson, J., Tsai, T. -S., Lagondar, S., Rodda, F., . . . Temple-Smith, P. (2019). The transgenerational effects of oocyte mitochondrial supplementation. Scientific Reports, 9(1), 6694-1-6694-12.
Scopus15 WoS12 Europe PMC122019 St John, J. C. (2019). Genomic balance: two genomes establishing synchrony to modulate cellular fate and function. Cells, 8(11), 1-14.
Scopus10 WoS9 Europe PMC122019 St John, J. C. (2019). Mitochondria and female germline stem cells−a mitochondrial DNA perspective. Cells, 8(8), 852-1-852-15.
Scopus13 WoS9 Europe PMC142019 Poulton, J., Steffann, J., Burgstaller, J., McFarland, R., Arbeithuber, B., Bengoa, J., . . . Wells, D. (2019). 243rd ENMC international workshop: Developing guidelines for management of reproductive options for families with maternally inherited mtDNA disease, Amsterdam, the Netherlands, 22-24 March 2019. NEUROMUSCULAR DISORDERS, 29(9), 725-733.
WoS9 Europe PMC132018 Sun, X., Vaghjiani, V., Jayasekara, W. S. N., Cain, J. E., & St John, J. C. (2018). The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.. Clinical epigenetics, 10(1), 157.
Scopus36 WoS26 Europe PMC272018 Sun, X., & St John, J. C. (2018). Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours. Epigenetics and Chromatin, 11(1), 53-1-53-18.
Scopus31 WoS23 Europe PMC262018 St John, J. C., & Tsai, T. -S. (2018). The association of mitochondrial DNA haplotypes and phenotypic traits in pigs.. BMC genetics, 19(41), 1-12.
Scopus18 WoS14 Europe PMC112018 Tsai, T. -S., & St John, J. C. (2018). The effects of mitochondrial DNA supplementation at the time of fertilization on the gene expression profiles of porcine preimplantation embryos.. Molecular reproduction and development, 85(6), 490-504.
Scopus17 WoS15 Europe PMC102018 Sun, X., Johnson, J., & St John, J. (2018). Global DNA methylation synergistically regulates the nuclear and mitochondrial genomes in glioblastoma cells. Nucleic Acids Research, 46(12), 5977-5995.
Scopus46 WoS37 Europe PMC422018 Tsai, T., Tyagi, S., & St John, J. (2018). The molecular characterisation of mitochondrial DNA deficient oocytes using a pig model. Human Reproduction, 33(5), 942-953.
Scopus22 WoS15 Europe PMC172018 Srirattana, K., & St John, J. (2018). Additional mitochondrial DNA influences the interactions between the nuclear and mitochondrial genomes in a bovine embryo model of nuclear transfer. Scientific Reports, 8(1), 17 pages.
Scopus26 WoS18 Europe PMC202018 St John, J. C., Srirattana, K., Tsai, T. S., & Sun, X. (2018). The mitochondrial genome: How it drives fertility. Reproduction, Fertility and Development, 30(1), 118-139.
Scopus7 WoS5 Europe PMC52017 Lee, W. T., Sun, X., Tsai, T. S., Johnson, J. L., Gould, J. A., Garama, D. J., . . . St John, J. C. (2017). Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns. Cell Death Discovery, 3(1), 1-11.
Scopus38 WoS29 Europe PMC312017 Srirattana, K., & St John, J. C. (2017). Manipulating the mitochondrial genome to enhance cattle embryo development. G3 : Genes, Genomes, Genetics, 7(7), 2065-2080.
Scopus24 WoS17 Europe PMC182017 Vaghjiani, V., Cain, J. E., Lee, W., Vaithilingam, V., Tuch, B. E., & St John, J. C. (2017). Modulation of Mitochondrial DNA Copy Number to Induce Hepatocytic Differentiation of Human Amniotic Epithelial Cells. Stem Cells and Development, 26(20), 1505-1519.
Scopus2 WoS2 Europe PMC12017 Tsai, T., Johnson, J., White, Y., & St John, J. (2017). The molecular characterization of porcine egg precursor cells. Oncotarget, 8(38), 63484-63505.
Scopus10 WoS10 Europe PMC112017 Srirattana, K., McCosker, K., Schatz, T., & St John, J. C. (2017). Cattle phenotypes can disguise their maternal ancestry. BMC Genetics, 18(59), 11 pages.
Scopus22 WoS17 Europe PMC92016 Sun, X., & John, J. C. S. (2016). The role of the mtDNA set point in differentiation, development and tumorigenesis. Biochemical Journal, 473(19), 2955-2971.
Scopus39 WoS30 Europe PMC262016 Tsai, T., & St John, J. C. (2016). The role of mitochondrial DNA copy number, variants, and haplotypes in farm animal developmental outcome. Domestic Animal Endocrinology, 56, S133-S146.
Scopus16 WoS12 Europe PMC92016 Lee, W. T. Y., & St. John, J. C. (2016). Mitochondrial DNA as an initiator of tumorigenesis. Cell Death and Disease, 7(3), 2 pages.
Scopus10 WoS8 Europe PMC72016 Cagnone, G., Tsai, T. S., Srirattana, K., Rossello, F., Powell, D. R., Rohrer, G., . . . St John, J. C. (2016). Segregation of naturally occurring mitochondrial DNA variants in a mini-pig model. Genetics, 202(3), 931-944.
Scopus21 WoS20 Europe PMC172016 Tsai, T., Rajasekar, S., & St John, J. (2016). The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus). BMC Genetics, 17(1), 67.
Scopus38 WoS32 Europe PMC202016 St John, J. C., Tsai, T. S., & Cagnone, G. L. M. (2016). Mitochondrial DNA supplementation as an enhancer of female reproductive capacity. Current Opinion in Obstetrics and Gynecology, 28(3), 211-216.
Scopus5 WoS4 Europe PMC42016 Cagnone, G. L. M., Tsai, T. S., Makanji, Y., Matthews, P., Gould, J., Bonkowski, M. S., . . . John, J. C. S. (2016). Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Scientific Reports, 6(1), 1-15.
Scopus73 WoS55 Europe PMC512016 St John, J. C. (2016). Mitochondrial DNA copy number and replication in reprogramming and differentiation. Seminars in Cell and Developmental Biology, 52, 93-101.
Scopus50 WoS35 Europe PMC362016 Johnson, J., Lee, W., Frazier, A. E., Vaghjiani, V., Laskowski, A., Rodriguez, A. L., . . . St John, J. C. (2016). Deletion of the Complex I Subunit NDUFS4 Adversely Modulates Cellular Differentiation. Stem Cells and Development, 25(3), 239-250.
Scopus8 WoS7 Europe PMC82016 Lee, W. T. Y., Cain, J. E., Cuddihy, A., Johnson, J., Dickinson, A., Yeung, K. Y., . . . St John, J. C. (2016). Mitochondrial DNA plasticity is an essential inducer of tumorigenesis. Cell Death Discovery, 2(1), 11 pages.
Scopus30 WoS26 Europe PMC242015 Lee, W., Johnson, J., Gough, D. J., Donoghue, J., Cagnone, G. L. M., Vaghjiani, V., . . . St John, J. C. (2015). Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny. Cell Death and Disease, 6(2), e1664.
Scopus90 WoS74 Europe PMC692015 Lee, W. T. Y., & John, J. S. (2015). The control of mitochondrial DNA replication during development and tumorigenesis. Annals of the New York Academy of Sciences, 1350(1), 95-106.
Scopus41 WoS34 Europe PMC292015 Henry, B. A., Loughnan, R., Hickford, J., Young, I. R., St John, J. C., & Clarke, I. (2015). Differences in mitochondrial DNA inheritance and function align with body conformation in genetically lean and fat sheep. Journal of Animal Science, 93(5), 2083-2093.
Scopus11 WoS10 Europe PMC72015 Wu, L., Russell, D., Wong, S., Chen, M., Tsai, T., St John, J., . . . Robker, R. (2015). Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors. Development, 142(4), 681-691.
Scopus231 WoS184 Europe PMC1622015 St John, J. C. (2015). The mitochondrion, its genome and their contribution to well-being and disease. Molecular Human Reproduction, 21(1), 1-2.
Scopus6 WoS2 Europe PMC62014 St John, J., Srirattana, K., & Clarke, I. (2014). Modifying the mitochondrial genome to enhance animal production. Australasian Biotechnology, 24(3), 61. 2014 Yeung, K. Y., Dickinson, A., Donoghue, J. F., Polekhina, G., White, S. J., Grammatopoulos, D. K., . . . St John, J. C. (2014). The identification of mitochondrial DNA variants in glioblastoma multiforme. Acta Neuropathologica Communications, 2(1), 1.
Scopus52 WoS45 Europe PMC552014 Sobinoff, A. P., Sutherland, J. M., Beckett, E. L., Stanger, S. J., Johnson, R., Jarnicki, A. G., . . . Mclaughlin, E. A. (2014). Damaging legacy: Maternal cigarette smoking has long-term consequences for male offspring fertility. Human Reproduction, 29(12), 2719-2735.
Scopus46 WoS41 Europe PMC322014 St John, J. (2014). The control of mtDNA replication during differentiation and development. Biochimica et Biophysica Acta - General Subjects, 1840(4), 1345-1354.
Scopus93 WoS73 Europe PMC712014 Nagley, P., St John, J., Gabriel, K., & McKenzie, M. (2014). Mitochondrial research in Australia: A major player in worldwide trends. Biochimica et Biophysica Acta - General Subjects, 1840(4), 1225-1226.
2014 Mckenzie, M., Chiotis, M., Hroudová, J., Lopez Sanchez, M., Lim, S., Cook, M., . . . Trounce, I. (2014). Capture of somatic mtDNA point mutations with severe effects on oxidative phosphorylation in synaptosome cybrid clones from human brain. Human Mutation, 35(12), 1476-1484.
Scopus12 WoS12 Europe PMC92014 Lee, T., Clarke, I., St John, J., Young, I., Leury, B., Rao, A., . . . Henry, B. (2014). High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle. FASEB Journal, 28(1), 35-44.
Scopus16 WoS15 Europe PMC112013 Dickinson, A., Yeung, K. Y., Donoghue, J., Baker, M. J., Kelly, R. D., McKenzie, M., . . . St John, J. C. (2013). The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death and Differentiation, 20(12), 1644-1653.
Scopus110 WoS97 Europe PMC982013 Kelly, R. D. W., Rodda, A. E., Dickinson, A., Mahmud, A., Nefzger, C. M., Lee, W., . . . St John, J. C. (2013). Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. Stem Cells, 31(4), 703-716.
Scopus65 WoS63 Europe PMC532013 Kelly, R. D. W., Sumer, H., McKenzie, M., Facucho-Oliveira, J., Trounce, I. A., Verma, P. J., & St John, J. C. (2013). The Effects of Nuclear Reprogramming on Mitochondrial DNA Replication. Stem Cell Reviews and Reports, 9(1), 1-15.
Scopus48 WoS39 Europe PMC362013 John, J. S. (2013). A tribute to somatic cell reprogrammers. Molecular Human Reproduction, 19(2), 55-56.
2012 Kelly, R. D. W., Mahmud, A., McKenzie, M., Trounce, I. A., & St John, J. C. (2012). Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Research, 40(20), 10124-10138.
Scopus155 WoS129 Europe PMC1232012 St John, J. C. (2012). Transmission, inheritance and replication of mitochondrial DNA in mammals: Implications for reproductive processes and infertility. Cell and Tissue Research, 349(3), 795-808.
Scopus26 WoS22 Europe PMC152011 Rae, P. C., Kelly, R. D., Egginton, S., & St John, J. C. (2011). Angiogenic potential of endothelial progenitor cells and embryonic stem cells. Vascular Cell, 3(1), 15 pages.
Scopus35 WoS30 Europe PMC212011 Sanchez-Partida, L., Kelly, R., Sumer, H., Lo, C., Aharon, R., Holland, M., . . . John St, J. (2011). The generation of live offspring from vitrified oocytes. PLoS ONE, 6(6), e21597.
Scopus19 WoS14 Europe PMC132011 Jiang, Y., Kelly, R., Peters, A., Fulka, H., Dickinson, A., Mitchell, D. A., & St. John, J. C. (2011). Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors. Plos One, 6(4), 12 pages.
Scopus47 WoS27 Europe PMC262011 Kelly, R. D. W., & St. John, J. C. (2011). Role of mitochondrial DNA replication during differentiation of reprogrammed stem cells. International Journal of Developmental Biology, 54(11-12), 1659-1670.
Scopus19 WoS11 Europe PMC122010 St John, J. C., & Campbell, K. H. S. (2010). The battle to prevent the transmission of mitochondrial DNA disease: Is karyoplast transfer the answer. Gene Therapy, 17(2), 147-149.
Scopus17 WoS15 Europe PMC82010 St. John, J. C., Facucho-Oliveira, J., Jiang, Y., Kelly, R., & Salah, R. (2010). Mitochondrial DNA transmission, replication and inheritance: A journey from the gamete through the embryo and into offspring and embryonic stem cells. Human Reproduction Update, 16(5), 488-509.
Scopus242 WoS191 Europe PMC1752010 Lee, J. H., Peters, A., Fisher, P., Bowles, E. J., St. John, J. C., & Campbell, K. H. S. (2010). Generation of mtDNA homoplasmic cloned lambs. Cellular Reprogramming, 12(3), 347-355.
Scopus30 WoS21 Europe PMC162009 Fulka, J., Loi, P., Ptak, G., Fulka, H., & John, J. S. (2009). Hope for the mammoth?. Cloning and Stem Cells, 11(1), 1-3.
Scopus7 WoS7 Europe PMC72009 Facucho-Oliveira, J. M., & John St., J. C. (2009). The relationship between pluripotency and mitochondrial DNA proliferation during early embryo development and embryonic Stem Cell differentiation. Stem Cell Reviews and Reports, 5(2), 140-158.
Scopus215 WoS179 Europe PMC1692009 Taylor, R. A., Wang, H., Wilkinson, S. E., Richards, M. G., Britt, K. L., Vaillant, F., . . . Risbridger, G. P. (2009). Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers. Stem Cells, 27(12), 3032-3042.
Scopus27 WoS26 Europe PMC212008 Fulka, J., Fulka, H., St John, J., Galli, C., Lazzari, G., Lagutina, I., . . . Loi, P. (2008). Cybrid human embryos - warranting opportunities to augment embryonic stem cell research. Trends in Biotechnology, 26(9), 469-474.
Scopus7 WoS5 Europe PMC32008 Bowles, E. J., Tecirlioglu, R. T., French, A. J., Holland, M. K., & St. John, J. C. (2008). Mitochondrial DNA transmission and transcription after somatic cell fusion to one or more cytoplasts. Stem Cells, 26(3), 775-782.
Scopus43 WoS34 Europe PMC262008 St John, J. C., Armstrong, L., Minger, S. L., & Campbell, K. H. S. (2008). Law should recognize value of interspecies embryos [1]. Nature, 451(7179), 627.
Scopus5 WoS6 Europe PMC32007 St John, J., & Lovell-Badge, R. (2007). Human-animal cytoplasmic hybrid embryos, mitochondria, and an energetic debate. Nature Cell Biology, 9(9), 988-992.
Scopus29 WoS19 Europe PMC152007 Bowles, E. J., Lee, J. H., Alberio, R., Lloyd, R. E. I., Stekel, D., Campbell, K. H. S., & St. John, J. C. (2007). Contrasting effects of in vitro fertilization and nuclear transfer on the expression of mtDNA replication factors. Genetics, 176(3), 1511-1526.
Scopus54 WoS48 Europe PMC402007 St John, J. C., Bowles, E. J., & Amaral, A. (2007). Sperm mitochondria and fertilisation.. Society of Reproduction and Fertility Supplement, 65, 399-416.
Scopus23 Europe PMC122007 Spikings, E. C., Alderson, J., & St. John, J. C. (2007). Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development. Biology of Reproduction, 76(2), 327-335.
Scopus228 WoS194 Europe PMC1692007 Amaral, A., Ramalho-Santos, J., & St John, J. C. (2007). The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm. Human Reproduction, 22(6), 1585-1596.
Scopus124 WoS100 Europe PMC872007 Facucho-Oliveira, J. M., Alderson, J., Spikings, E. C., Egginton, S., & St. John, J. C. (2007). Mitochondrial DNA replication during differentiation of murine embryonic stem cells. Journal of Cell Science, 120(22), 4025-4034.
Scopus250 WoS228 Europe PMC2142007 Fulka, J., Fulka, H., & St. John, J. C. (2007). Transmission of mitochondrial DNA disorders: Possibilities for the elimination of mutated mitochondria. Cloning and Stem Cells, 9(1), 47-50.
Scopus8 WoS6 Europe PMC62006 Spikings, E. C., Alderson, J., & St. John, J. C. (2006). Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer. Human Reproduction Update, 12(4), 401-415.
Scopus67 WoS60 Europe PMC432006 Poulton, J., Kennedy, S., Oakeshott, P., & St John, J. (2006). Nuclear transfer to prevent mitochondrial DNA diseases. Lancet, 368(9538), 841.
Scopus9 WoS7 Europe PMC52006 Santos, T. A., El Shourbagy, S., & St. John, J. C. (2006). Mitochondrial content reflects oocyte variability and fertilization outcome. Fertility and Sterility, 85(3), 584-591.
Scopus347 WoS292 Europe PMC2562006 Lloyd, R. E., Lee, J. H., Alberio, R., Bowles, E. J., Ramalho-Santos, J., Campbell, K. H. S., & St. John, J. C. (2006). Aberrant nucleo-cytoplasmic cross-talk results in donor cell mtDNA persistence in cloned embryos. Genetics, 172(4), 2515-2527.
Scopus61 WoS54 Europe PMC422006 St John, J. C., Amaral, A., Bowles, E., Oliveira, J. F., Lloyd, R., Freitas, M., . . . Ramalho-Santos, J. (2006). The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells.. Methods in Molecular Biology Clifton N J, 331, 347-374.
Scopus48 Europe PMC442006 El Shourbagy, S. H., Spikings, E. C., Freitas, M., & St. John, J. C. (2006). Mitochondria directly influence fertilisation outcome in the pig. Reproduction, 131(2), 233-245.
Scopus279 WoS246 Europe PMC2052005 Fleming, C., Maldjian, A., Da Costa, D., Rullay, A. K., Haddleton, D. M., St John, J., . . . Davis, B. G. (2005). A Carbohydrate-Antioxidant Hybrid Polymer Reduces Oxidative Damage in Spermatozoa and Enhances Fertility. Nature Chemical Biology, 1(5), 270-274.
Scopus65 WoS59 Europe PMC262005 St. John, J. C., Moffatt, O., & D'Souza, N. (2005). Aberrant heteroplasmic transmission of mtDNA in cloned pigs arising from double nuclear transfer. Molecular Reproduction and Development, 72(4), 450-460.
Scopus38 WoS30 Europe PMC252005 St John, J. C., & Alderson, J. (2005). Stem-cell banking: The size of the task. Lancet, 366(9502), 1991-1992.
Scopus3 WoS1 Europe PMC22005 St. John, J. C., Ramalho-Santos, J., Gray, H. L., Petrosko, P., Rawe, V. Y., Navara, C. S., . . . Schatten, G. P. (2005). The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stemn cells. Cloning and Stem Cells, 7(3), 141-153.
Scopus216 WoS185 Europe PMC1722005 St. John, J. C., Jokhi, R. P., & Barratt, C. L. R. (2005). The impact of mitochondrial genetics on male infertility. International Journal of Andrology, 28(2), 65-73.
Scopus100 WoS74 Europe PMC682004 St. John, J. C., & Schatten, G. (2004). Paternal mitochondrial DNA transmission during nonhuman primate nuclear transfer. Genetics, 167(2), 897-905.
Scopus67 WoS51 Europe PMC352004 St. John, J. C., Lloyd, R. E. I., Bowles, E. J., Thomas, E. C., & El Shourbagy, S. (2004). The consequences of nuclear transfer for mammalian foetal development and offspring survival. A mitochondrial DNA perspective. Reproduction, 127(6), 631-641.
Scopus77 WoS59 Europe PMC502004 Mital, D., White, D. J., & St John, J. C. (2004). Mitochondrial DNA and sperm quality in patients on antiretroviral therapy - Response [3]. AIDS, 18(6), 963.
Scopus4 WoS4 Europe PMC42004 Barratt, C. L. R., St. John, J. C., & Afnan, M. (2004). Clinical challenges in providing embryos for stem-cell initiatives. Lancet, 364(9429), 115-118.
Scopus21 WoS17 Europe PMC142004 St John, J. C., Lloyd, R., & El Shourbagy, S. (2004). The potential risks of abnormal transmission of mtDNA through assisted reproductive technologies. Reproductive Biomedicine Online, 8(1), 34-44.
Scopus33 WoS23 Europe PMC132003 Payne, C., St. John, J. C., Ramalho-Santos, J., & Schatten, G. (2003). LIS1 Association with Dynactin is Required for Nuclear Motility and Genomic Union in the Fertilized Mammalian Oocyte. Cell Motility and the Cytoskeleton, 56(4), 245-251.
Scopus18 WoS16 Europe PMC162002 Perkins, J., St. John, J., & Ahmed, A. (2002). Modulation of trophoblast cell death by oxygen and EGF. Molecular Medicine, 8(12), 847-856.
Scopus25 WoS24 Europe PMC232002 St. John, J. C. (2002). Ooplasm donation in humans: The need to investigate the transmission of mitochondrial DNA following cytoplasmic transfer. Human Reproduction, 17(8), 1954-1958.
Scopus48 WoS42 Europe PMC302001 White, D. J., Mital, D., Taylor, S., & John, J. C. S. (2001). Sperm mitochondrial DNA deletions as a consequence of long term highly active antiretroviral therapy. AIDS, 15(8), 1061-1062.
Scopus57 WoS39 Europe PMC322001 St. John, J. C., Jokhi, R. P., & Barratt, C. L. R. (2001). Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology. Molecular Human Reproduction, 7(1), 103-111.
Scopus89 WoS74 Europe PMC612000 John, J. C. S., & De Jonge, C. J. (2000). A hypothesis for transmission of paternal mitochondrial DNA. Reproductive Medicine Review, 8(1), 73-85.
Scopus62000 St. John, J. C., Sakkas, D., & Barratt, C. L. R. (2000). A role for mitochondrial DNA and sperm survival. Journal of Andrology, 21(2), 189-199.
Scopus60 WoS57 Europe PMC332000 Ahmed, A., Rahman, M., Zhang, X., Acevedo, C. H., Nijjar, S., Rushton, I., . . . St. John, J. (2000). Induction of Placental Heme Oxygenase-1 Is Protective Against TNFα-induced Cytotoxicity and Promotes Vessel Relaxation. Molecular Medicine, 6(5), 391-409.
Scopus144 WoS132 Europe PMC1092000 St John, J., Sakkas, D., Dimitriadi, K., Barnes, A., Maclin, V., Ramey, J., . . . De Jonge, C. (2000). Failure of elimination of paternal mitochondrial DNA in abnormal embryos. Lancet, 355(9199), 200.
Scopus84 WoS71 Europe PMC501999 St. John, J. C. (1999). Incorporating molecular screening techniques into the modern andrology laboratory. Journal of Andrology, 20(6), 692-701.
Scopus9 WoS4 Europe PMC11999 Sakkas, D., Mariethoz, E., & St. John, J. C. (1999). Abnormal sperm parameters in humans are indicative of an abortive apoptotic mechanism linked to the fas-mediated pathway. Experimental Cell Research, 251(2), 350-355.
Scopus307 WoS251 Europe PMC1791997 St. John, J. C., Cooke, I. D., Barratt, C. L. R., & Johns, D. R. (1997). Mitochondrial mutations and male infertility [2]. Nature Medicine, 3(2), 124-125.
Scopus59 WoS68 Europe PMC311997 St John, J. C., Barratt, C. L. R., Brenner, C. A., Scott, J., & Cohen, J. (1997). Use of anucleate donor oocyte cytoplasm in recipient eggs (multiple letters) [16]. Lancet, 350(9082), 961-962.
Scopus2 WoS12 Europe PMC11- St. John, J. C. (n.d.). Mitochondrial<scp>DNA</scp>: Fate of the Paternal Mitochondrial Genome.
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Books
Year Citation 2013 St. John, J. C. (2013). Mitochondrial DNA, mitochondria, disease and stem cells. J. C. St. John (Ed.), Humana Press.
DOI2007 St John, J. C. (2007). Preface (Vol. 77). Elsevier.
DOI2007 Bowles, E. J., Campbell, K. H. S., & St. John, J. C. (2007). Nuclear Transfer: Preservation of a Nuclear Genome at the Expense of Its Associated mtDNA Genome(s) (Vol. 77). J. C. StJohn (Ed.), ELSEVIER ACADEMIC PRESS INC.
DOI Scopus49 WoS36 Europe PMC27 -
Book Chapters
Year Citation 2019 Srirattana, K., & St John, J. (2019). Transmission of Dysfunctional Mitochondrial DNA and Its Implications for Mammalian Reproduction. In P. Sutovsky (Ed.), Cellular and Molecular Basis of Mitochondrial Inheritance (Vol. 231, pp. 75-103). Switzerland: Springer Nature.
DOI Scopus13 WoS11 Europe PMC82016 Cagnone, G., Vaghjiani, V., Lee, W., Sun, C., Johnson, J., Yeung, K. Y., & St John, J. C. (2016). Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. In K. Turksen, & A. Nagy (Eds.), Induced Pluripotent Stem (iPS) Cells: Methods and Protocols (Vol. 1357, pp. 231-267). New York; USA: Springer.
DOI Scopus2 Europe PMC22016 Sun, X., Lee, W., Vaghjiani, V., & St John, J. C. (2016). Analysis of mitochondrial DNA copy number and its regulation through DNA methylation of POLGA. In M. McKenzie (Ed.), Mitochondrial DNA: Methods and Protocols (Vol. 1351, pp. 131-141). New York; USA: Springer.
DOI Scopus5 Europe PMC42015 Lee, W., Kelly, R. D. W., Yeung, K. Y., Cagnone, G., McKenzie, M., & St John, J. C. (2015). Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells. In P. J. Verma, & H. Sumer (Eds.), Cell Reprogramming: Methods and Protocols (Vol. 1330, pp. 219-252). New York; USA: Springer.
DOI Scopus3 Europe PMC12013 Yeung, K. Y., Dickinson, A., & St. John, J. C. (2013). The Role of Mitochondrial DNA in Tumorigenesis. In Mitochondrial DNA Mitochondria Disease and Stem Cells (pp. 119-155). Humana Press.
DOI Scopus12013 Facucho-Oliveira, J., Kulkarni, T., Machado-Oliveira, G., & St. John, J. C. (2013). From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases. In Mitochondrial DNA Mitochondria Disease and Stem Cells (pp. 87-118). Humana Press.
DOI2013 St. John, J. C. (2013). Mitochondrial DNA: Its Transmission from Gametes and Embryos. In Principles of Cloning Second Edition (pp. 429-439). Elsevier.
DOI Scopus12013 Kelly, R. D. W., Mahmud, A., & St. John, J. C. (2013). Assisted Reproductive Technologies: The Potential to Prevent the Transmission of Mutant mtDNA from One Generation to the Next. In Mitochondrial DNA Mitochondria Disease and Stem Cells (pp. 157-183). Humana Press.
DOI2012 St. John, J. C., & Campbell, K. H. S. (2012). The consequences of reprogramming a somatic cell for mitochondrial DNA transmission, inheritance and replication. In Nuclear Reprogramming and Stem Cells (pp. 83-97). Humana Press.
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Conference Papers
Year Citation 2014 St John, J. C. (2014). SUPPLEMENTING OOCYTES WITH AUTOLOGOUS MITOCHONDRIA ENHANCES FERTILIZATION OUTCOMES.. In FERTILITY AND STERILITY Vol. 102 (pp. E330). Honolulu, HI: ELSEVIER SCIENCE INC.
DOI2012 Lee, Y. S., MacIntyre, D. A., Pirianov, G., Herbert, B., Terzidou, V., Johnson, M. R., & Bennett, P. R. (2012). Inhibition of AP1 Delays LPS-Induced Preterm Labour and Improves Pup Outcome in the Murine Model. In REPRODUCTIVE SCIENCES Vol. 19 (pp. 120A). SAGE PUBLICATIONS INC. 2009 St. John, J. C. (2009). mtDNA and sperm function. In Systems Biology in Reproductive Medicine Vol. 55 (pp. 17-18). 2008 Fulka, H., St. John, J. C., Fulka, J., & Hozák, P. (2008). Chromatin in early mammalian embryos: Achieving the pluripotent state. In Differentiation Vol. 76 (pp. 3-14). England: ELSEVIER SCI LTD.
DOI Scopus50 WoS43 Europe PMC292004 Ramalho-Santos, J., Sammak, P., Chong, K. Y., Qidwai, H., Rawe, V. Y., St John, J. C., & Schatten, G. (2004). Membrane trafficking and organelle dynamics in undifferentiated embryonic stem cells: Endomembrane biogenesis and expansion coupled with differentiation.. In BIOLOGY OF REPRODUCTION (pp. 216-217). Univ British Columbia, Vancouver, CANADA: SOC STUDY REPRODUCTION. 2002 St. John, J. C. (2002). The transmission of mitochondrial DNA following assisted reproductive techniques. In Theriogenology Vol. 57 (pp. 109-123). FOZ DO IGUACU, BRAZIL: ELSEVIER SCIENCE INC.
DOI Scopus44 WoS39 Europe PMC302000 O'Connell, M., St John, J. C., McClure, N., Steele, E. K., & Lewis, S. E. M. (2000). A comparison of mitochondrial DNA deletions in proximal epididymal and testicular spermatozoa in males with obstructive azoospermia. In HUMAN REPRODUCTION Vol. 15 (pp. 114-115). OXFORD UNIV PRESS. 1999 Barratt, C. L. R., St John, J. C., & Afnan, M. (1999). Genetic testing of the male.. In C. Gagnon (Ed.), MALE GAMETE: FROM BASIC SCIENCE TO CLINICAL APPLICATIONS (pp. 397-405). MONTREAL, CANADA: CACHE RIVER PRESS.
WoS11998 Barratt, C. L. R., & St John, J. C. (1998). Diagnostic tools in male infertility. In Human Reproduction Vol. 13 (pp. 51-61). THESSALONIKI, GREECE: OXFORD UNIV PRESS.
DOI Scopus13 WoS9 Europe PMC51997 St John, J. C., Cooke, I. D., & Barratt, C. L. R. (1997). The Use of Long PCR to detect multiple deletions in the mitochondrial DNA of human testicular tissue from azoospermic and severe oligozoospermic patients. In C. Barratt, C. DeJonge, D. Mortimer, & J. Parinaud (Eds.), GENETICS OF HUMAN MALE FERTILITY (pp. 333-347). COLLIOURE, FRANCE: EDITIONS EDK.
WoS61997 StJohn, J. C., Jokhi, R. P., Barratt, C. L. R., & Cooke, I. D. (1997). The effects of mitochondrial dysfunction on sperm motility. In HUMAN REPRODUCTION Vol. 12 (pp. P11). OXFORD UNIV PRESS. -
Conference Items
Year Citation 2014 Chang, J. R., Chang, C. W., Chao, S. J., Cheng, A., Dai, K., Lee, J. T., . . . Yang, C. P. (2014). Preface. Poster session presented at the meeting of Geotechnical Special Publication.
2021 – 2025 NHMRC Ideas Grant (GNT2000723), Understanding the benefits and limitations of metaphase II spindle transfer (St. John J) $1,629,373.
2019 – 2022: NHMRC Project Grant (GNT1160106), Understanding how mitochondrial DNA contributes to embryo development (St. John J) $669,790
2018 – 2020: NHMRC Development Grant (GNT1136065), Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity (St. John J, McKenzie W, Western P, Rombauts L) $670,867.20.
2017 – 2018: The Winston Foundation (WF1), Developing a canine in vitro maturation culture system (St. John J) $42,000
2016 – 2018: OvaScience Inc. Waltham, USA. Renewal Grant, Safety of Mitochondrial Transfer (St. John J) $600,000.
2016 – 2019: ARC Discovery Grant(DP160102575), Diet influences the selective advantage of mitochondrial DNA mutations (Ballard B, St. John J, Smyth G) $313,600.00
2015 – 2017: NHMRC Project Grant(GNT1079309) - Metabolic and molecular basis of embryo signalling (Lane M, St. John J, Zander-Fox D) $397,077.00
2014 – 2016: Australian Mitochondrial Disease Foundation- Preventing the transmission of mutant mitochondrial DNA (St. John J) $25,000
2013 – 2016: OvaScience Inc- Determining the safety of homologous mitochondrial transfer in a mini-pig model (St. John J) $1,250,000
2013 – 2015: NHMRC Project Grant(GNT1041471) - Understanding mitochondrial DNA segregation and transmission (CIA - St. John J; Trounce I) $492,863
2013 – 2015: Zwart Estate- The role of mtDNA variants in glioblastoma (St. John J) $133,131
2013 – 2016: Australian Pork Limited- Defining the role of mitochondrial DNA in pig fertility (St. John J) $92,637
2013 – 2014: Johnston Estate- The generation of stem cell models of mtDNA disease (St. John J) $170,000
2012 – 2014: NHMRC Project Grant(GNT1022222) - Understanding the pathogenesis of mitochondrial disease using iPS cells (Thorburn D, St. John J, Frazier A, Nisbet D, White S) $618,675
2011: Marian and EH Flack Trust- Funding to purchase a High Resolution Melting Curve Analysis Machine(White S, Western P, St. John J, Watkins DN) $30,000.
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Committee Memberships
Date Role Committee Institution Country 2019 - 2020 Member Mitochondrial Donation Expert Working Committee National Health and Medical Research Council Australia 2018 - 2021 Member Embryo Research Licencing Committee National Health and Medical Reseach Council Australia
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